fig|1040638.4.peg.3634
Escherichia coli O104:H4 str. LB226692
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
KE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|6666666.5357.peg.2359
Escherichia coli TY-2482 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
KE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|585055.6.peg.1783
Escherichia coli 55989
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
KE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|585055.8.peg.1787
Escherichia coli 55989
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
KE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|344601.3.peg.332
Escherichia coli B171 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
KE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|344601.5.peg.330
Escherichia coli B171
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
KE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|679205.4.peg.1618
Escherichia coli MS 124-1 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
KE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|679205.4.peg.1619
Escherichia coli MS 124-1
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
KE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|749533.3.peg.4938
Escherichia coli MS 84-1
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
KE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|749545.3.peg.5107
Escherichia coli MS 182-1 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEV
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
KE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|749532.3.peg.1356
Escherichia coli MS 78-1 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEV
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
KE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|749532.3.peg.1357
Escherichia coli MS 78-1
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEV
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
KE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|358709.5.peg.1103
Escherichia coli 101-1
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|481805.3.peg.2200
Escherichia coli ATCC 8739 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|481805.6.peg.2193
Escherichia coli ATCC 8739
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|413997.3.peg.1632
Escherichia coli B str. REL606
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|550672.3.peg.2428
Escherichia coli B088 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|550676.3.peg.1892
Escherichia coli B185
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|511693.5.peg.1657
Escherichia coli BL21
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|469008.4.peg.2117
Escherichia coli BL21(DE3)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|595496.3.peg.1548
Escherichia coli BW2952
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|536056.3.peg.2166
Escherichia coli DH1
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|340186.3.peg.16
Escherichia coli E110019 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|340186.5.peg.17
Escherichia coli E110019
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|331111.12.peg.2082
Escherichia coli E24377A (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|331111.3.peg.4225
Escherichia coli E24377A (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|316401.4.peg.1868
Escherichia coli ETEC H10407 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|316401.4.peg.1869
Escherichia coli ETEC H10407
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|656408.3.peg.1727
Escherichia coli H591 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|656408.3.peg.1728
Escherichia coli H591 (10-807/807)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|83333.1.peg.1574
Escherichia coli K12 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|595495.4.peg.2852
Escherichia coli KO11
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|679207.4.peg.4677
Escherichia coli MS 107-1 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|679207.4.peg.4678
Escherichia coli MS 107-1
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|749538.3.peg.4137
Escherichia coli MS 116-1
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|679206.4.peg.1317
Escherichia coli MS 119-7
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|749540.3.peg.4221
Escherichia coli MS 146-1 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|656443.3.peg.2236
Escherichia coli TA271
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|566546.3.peg.1065
Escherichia coli W
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|566546.4.peg.1740
Escherichia coli W
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|316407.3.peg.1545
Escherichia coli W3110 (10-807/807)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|316385.5.peg.1700
Escherichia coli str. K-12 substr. DH10B (10-807/807)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|316385.7.peg.1745
Escherichia coli str. K-12 substr. DH10B
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|511145.12.peg.1659
Escherichia coli str. K-12 substr. MG1655 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|511145.6.peg.1643
Escherichia coli str. K-12 substr. MG1655
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|679204.3.peg.505
Escherichia coli MS 145-7 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
V
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|585396.4.peg.2137
Escherichia coli O111:H- str. 11128 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
V
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|573235.3.peg.2330
Escherichia coli O26:H11 str. 11368
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
V
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|340185.3.peg.3274
Escherichia coli E22 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
R
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
KE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|340185.4.peg.3450
Escherichia coli E22
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
R
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
KE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|670888.3.peg.75
Escherichia coli 1827-70
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEV
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|562.375.peg.1687
Escherichia coli EC4100B (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEV
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|562.375.peg.1688
Escherichia coli EC4100B
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEV
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|656414.3.peg.1890
Escherichia coli H736 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TK
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|656414.3.peg.1891
Escherichia coli H736
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TK
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|331112.3.peg.1564
Escherichia coli HS (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEV
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|331112.6.peg.1631
Escherichia coli HS
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEV
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|749548.3.peg.4735
Escherichia coli MS 196-1
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
V
KRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|409438.11.peg.1856
Escherichia coli SE11 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEV
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|585034.4.peg.1622
Escherichia coli IAI1
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQ
N
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|585034.5.peg.1617
Escherichia coli IAI1
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQ
N
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|585395.4.peg.1811
Escherichia coli O103:H2 str. 12009 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
LIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
KE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|216592.1.peg.2170
Escherichia coli 042 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAET
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
ATIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|216592.3.peg.1806
Escherichia coli 042
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAET
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
ATIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|550677.3.peg.2970
Escherichia coli B354
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAET
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
ATIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|749531.3.peg.4806
Escherichia coli MS 69-1 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
EY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
ATIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|562.371.peg.4431
Escherichia coli 1044A
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|562.373.peg.5333
Escherichia coli 1125A (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|562.372.peg.4663
Escherichia coli 1212A (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|562.372.peg.4664
Escherichia coli 1212A
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|562.374.peg.4446
Escherichia coli 536A (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|83334.1.peg.2323
Escherichia coli O157:H7 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|444454.5.peg.5572
Escherichia coli O157:H7 str. EC4024 (10-807/807)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|444449.5.peg.518
Escherichia coli O157:H7 str. EC4042 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|444448.5.peg.4826
Escherichia coli O157:H7 str. EC4045 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|444453.5.peg.4691
Escherichia coli O157:H7 str. EC4076 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|444452.5.peg.3535
Escherichia coli O157:H7 str. EC4113 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|444450.8.peg.2338
Escherichia coli O157:H7 str. EC4115 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|444451.5.peg.3358
Escherichia coli O157:H7 str. EC4196 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|444447.5.peg.5163
Escherichia coli O157:H7 str. EC4206 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|478004.5.peg.4147
Escherichia coli O157:H7 str. EC4401 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|478005.5.peg.5248
Escherichia coli O157:H7 str. EC4486 (10-807/807)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|478006.5.peg.4086
Escherichia coli O157:H7 str. EC4501
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|478007.5.peg.3502
Escherichia coli O157:H7 str. EC508 (10-807/807)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|478008.5.peg.4498
Escherichia coli O157:H7 str. EC869 (10-807/807)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|637388.3.peg.5056
Escherichia coli O157:H7 str. FRIK2000 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|570506.3.peg.4177
Escherichia coli O157:H7 str. FRIK966 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|386585.9.peg.2402
Escherichia coli O157:H7 str. Sakai (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|544404.4.peg.2201
Escherichia coli O157:H7 str. TW14359 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|502346.5.peg.5111
Escherichia coli O157:H7 str. TW14588 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|701177.3.peg.1979
Escherichia coli O55:H7 str. CB9615
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAET
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|656379.3.peg.2056
Escherichia coli FVEC1302 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEV
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
H
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
ATIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|656380.3.peg.3019
Escherichia coli FVEC1412 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEV
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
H
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
ATIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|749549.3.peg.5226
Escherichia coli MS 198-1
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEV
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
H
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
ATIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|585056.7.peg.2060
Escherichia coli UMN026 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEV
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
H
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
ATIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|656437.3.peg.1799
Escherichia coli TA143 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
EY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
H
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
ATIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|656437.3.peg.1800
Escherichia coli TA143
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
EY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
H
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
ATIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|340184.3.peg.1014
Escherichia coli B7A (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YRVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
V
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|656393.3.peg.2376
Escherichia coli H299
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
I
I
SDNLRRIL
K
EY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
ATIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|749527.3.peg.4300
Escherichia coli MS 21-1
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAET
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
ATIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
T
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|749537.3.peg.2398
Escherichia coli MS 115-1
MKAEISRR
N
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAET
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
I
I
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWV
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|585057.4.peg.1536
Escherichia coli IAI39 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
A
IN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
ATIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|585057.6.peg.1536
Escherichia coli IAI39 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
A
IN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
ATIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|405955.13.peg.1671
Escherichia coli APEC O1
M
S
AEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
PR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|405955.9.peg.1356
Escherichia coli APEC O1 (11-808/808)
M
S
AEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
PR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|714962.3.peg.1739
Escherichia coli IHE3034
M
S
AEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
PR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|585035.6.peg.1626
Escherichia coli S88
M
S
AEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
PR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|869729.3.peg.1959
Escherichia coli UM146
M
S
AEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
PR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|364106.7.peg.1818
Escherichia coli UTI89
M
S
AEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
PR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|364106.8.peg.1821
Escherichia coli UTI89
M
S
AEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
PR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|656444.3.peg.2478
Escherichia coli TA280 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
I
I
SDNLRRIL
K
EY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
S
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
ATIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|199310.1.peg.1916
Escherichia coli CFT073 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWL
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
PR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|199310.4.peg.1847
Escherichia coli CFT073
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWL
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
PR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|749546.3.peg.3878
Escherichia coli MS 185-1
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWL
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
PR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|749528.3.peg.3856
Escherichia coli MS 45-1
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWL
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
PR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|670897.3.peg.2336
Escherichia coli 2362-75
M
S
AEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
T
D
SIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|216593.1.peg.356
Escherichia coli E2348/69 (11-808/808)
M
S
AEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
T
D
SIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|585397.7.peg.1776
Escherichia coli ED1a
M
S
AEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
T
D
SIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|585397.9.peg.1771
Escherichia coli ED1a
M
S
AEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
T
D
SIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|574521.7.peg.1709
Escherichia coli O127:H6 str. E2348/69
M
S
AEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
T
D
SIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|525281.3.peg.975
Escherichia coli 83972
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWL
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
PR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTI
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|655817.3.peg.1869
Escherichia coli ABU 83972 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWL
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
PR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTI
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|655817.3.peg.1870
Escherichia coli ABU 83972
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWL
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
PR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTI
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|656417.3.peg.2078
Escherichia coli M605 (11-808/808)
M
S
AEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
S
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
ATIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRGTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|656417.3.peg.2079
Escherichia coli M605 (10-807/807)
M
S
AEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
S
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
ATIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRGTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|155864.1.peg.2331
Escherichia coli O157:H7 EDL933 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
XRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
XY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHX
PSP
-
L
X
K
GNPSHSN
LV
Q
IEKV
fig|155864.8.peg.2170
Escherichia coli O157:H7 EDL933 (11-808/808)
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
R
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
XRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
TR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTNE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
P
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
XY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHX
PSP
-
L
X
K
GNPSHSN
LV
Q
IEKV
fig|753642.3.peg.1575
Escherichia coli NC101
MKAEISRR
S
LMK
T
S
A
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQA
P
-----
V
-E---
EK
AVWSSCTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
--------
YWVES--
D
T
T
GD
D
VY
-
G
N
HQVR
A
C
LR
G
RSIRR
RM
NH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVL
Y
GT
G
VD
G
GNITNS----NV
-
PY
RLMN
SC
GG
FLS
----
RY
G
S
YS
T
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
V
T
-----
YYVEQA
RE
R
SN
AR
M
-
I
V
IDP
R
Y
ND
T
AAGRE
DE
--
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PRNAH
YK
A
Y
IL
GEG
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
KI
I
Q
LA
L
E
IGS
A
K
P
-
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWL
P
--
M
L
-
E
N
PVKTQ
IS
VFT
W
TD
A
IDH
G
TE
MTA
PR-----
DGVR
---------
GK
EKL
D
VP
IK
FL
W
CY
A
S
N
TLINQ
H
G
DIN
HTHE
-----------------------
V
LQD
DS
K
C
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESAG
NM
GYVILAQ
P
ATSAK
FE
R
K
P
I
YWMLS
E
V
AKRL
G
P
DVYQTF
TEGR
S
Q
HE
W
I
K
Y
L
H
--
A
KTK
E
RN
S
E--
--------------------------------------------------------
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
L
AKIAD
TWEL
KKDEIIH
P
LPAYTPG
F
D
GWDDPLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YG
-
N
IDV
L
QQ
----
A
C
P
Q
E
V
-
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TA
I
GQ
GAW
LK
A
DMFGDRVDHG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|753642.3.peg.1576
Escherichia coli NC101 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
ADGFS
LPF
T--LRSAEA
A
-----
V
-QQAN
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|525281.3.peg.976
Escherichia coli 83972 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAEA
A
-----
V
-QQAN
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|655817.3.peg.1868
Escherichia coli ABU 83972 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAEA
A
-----
V
-QQAN
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|405955.13.peg.1670
Escherichia coli APEC O1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAEA
A
-----
V
-QQAN
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|405955.9.peg.1355
Escherichia coli APEC O1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAEA
A
-----
V
-QQAN
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|199310.1.peg.1915
Escherichia coli CFT073 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAEA
A
-----
V
-QQAN
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|199310.4.peg.1846
Escherichia coli CFT073 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAEA
A
-----
V
-QQAN
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|749546.3.peg.3879
Escherichia coli MS 185-1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAEA
A
-----
V
-QQAN
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|749528.3.peg.3857
Escherichia coli MS 45-1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAEA
A
-----
V
-QQAN
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|585035.6.peg.1625
Escherichia coli S88 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAEA
A
-----
V
-QQAN
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|364106.7.peg.1817
Escherichia coli UTI89 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAEA
A
-----
V
-QQAN
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|364106.8.peg.1820
Escherichia coli UTI89 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAEA
A
-----
V
-QQAN
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|344601.3.peg.331
Escherichia coli B171 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAR
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|344601.5.peg.329
Escherichia coli B171 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAR
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|340184.3.peg.1015
Escherichia coli B7A (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAR
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|340184.6.peg.1050
Escherichia coli B7A (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAR
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|679204.3.peg.504
Escherichia coli MS 145-7 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAR
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|439855.10.peg.1773
Escherichia coli SMS-3-5 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSSAA
A
-----
V
-QQAS
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GN
D
EY
-
G
N
Q
QVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
E
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
NR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|585395.4.peg.1810
Escherichia coli O103:H2 str. 12009 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAR
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|670897.3.peg.2337
Escherichia coli 2362-75 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAEA
A
-----
V
-QQAN
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPEHSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|216593.1.peg.355
Escherichia coli E2348/69 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAEA
A
-----
V
-QQAN
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPEHSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|574521.7.peg.1708
Escherichia coli O127:H6 str. E2348/69 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAEA
A
-----
V
-QQAN
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPEHSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|685038.3.peg.1602
Escherichia coli O83:H1 str. NRG 857C (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAEA
A
-----
V
-QQAN
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
NLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|595495.4.peg.2853
Escherichia coli KO11 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAR
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IV
I
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|566546.3.peg.1066
Escherichia coli W (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAR
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IV
I
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|566546.4.peg.1739
Escherichia coli W (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAR
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IV
I
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|550672.3.peg.2427
Escherichia coli B088 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
T
-----
V
-QQAS
EK
VIWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
T
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|481805.3.peg.2201
Escherichia coli ATCC 8739 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRNAAA
S
-----
V
-QQAR
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|481805.6.peg.2194
Escherichia coli ATCC 8739 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRNAAA
S
-----
V
-QQAR
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|595496.3.peg.1547
Escherichia coli BW2952 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRNAAA
A
-----
V
-QQAR
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|536056.3.peg.2167
Escherichia coli DH1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRNAAA
A
-----
V
-QQAR
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|656414.3.peg.1889
Escherichia coli H736 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRNAAA
A
-----
V
-QQAR
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|83333.1.peg.1573
Escherichia coli K12 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRNAAA
A
-----
V
-QQAR
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|749538.3.peg.4136
Escherichia coli MS 116-1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRNAAA
A
-----
V
-QQAR
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|749540.3.peg.4220
Escherichia coli MS 146-1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRNAAA
A
-----
V
-QQAR
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|749548.3.peg.4734
Escherichia coli MS 196-1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRNAAA
A
-----
V
-QQAR
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|316407.3.peg.1544
Escherichia coli W3110 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRNAAA
A
-----
V
-QQAR
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|316385.5.peg.1699
Escherichia coli str. K-12 substr. DH10B (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRNAAA
A
-----
V
-QQAR
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|316385.7.peg.1744
Escherichia coli str. K-12 substr. DH10B (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRNAAA
A
-----
V
-QQAR
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|511145.12.peg.1658
Escherichia coli str. K-12 substr. MG1655 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRNAAA
A
-----
V
-QQAR
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|511145.6.peg.1642
Escherichia coli str. K-12 substr. MG1655 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRNAAA
A
-----
V
-QQAR
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|562.375.peg.1686
Escherichia coli EC4100B (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
T
-----
V
-QQAS
EK
VIWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
T
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|749532.3.peg.1355
Escherichia coli MS 78-1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
T
-----
V
-QQAS
EK
VIWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
T
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|409438.11.peg.1855
Escherichia coli SE11 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
T
-----
V
-QQAS
EK
VIWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
T
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|585034.4.peg.1621
Escherichia coli IAI1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
T
-----
V
-QQAS
EK
VIWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
T
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IV
I
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|585034.5.peg.1616
Escherichia coli IAI1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
T
-----
V
-QQAS
EK
VIWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
T
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IV
I
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|656440.3.peg.4366
Escherichia coli TA206 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAN
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GN
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWVLS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSIFP
L
----
QL
F
G
F
H
YKS
R
A
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEKV
fig|340186.3.peg.17
Escherichia coli E110019 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
T
-----
V
-QQAS
EK
VIWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
T
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IV
I
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
L
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|340186.5.peg.18
Escherichia coli E110019 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
T
-----
V
-QQAS
EK
VIWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
T
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IV
I
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
L
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|550676.3.peg.1891
Escherichia coli B185 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LHSAAA
A
-----
V
-QQAR
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
AWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
E
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|679205.4.peg.1617
Escherichia coli MS 124-1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
T
-----
V
-QQAS
EK
VIWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
T
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NISGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|749533.3.peg.4939
Escherichia coli MS 84-1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
T
-----
V
-QQAS
EK
VIWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
T
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NISGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|656437.3.peg.1798
Escherichia coli TA143 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GN
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|550677.3.peg.2969
Escherichia coli B354 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPD
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|316401.4.peg.1867
Escherichia coli ETEC H10407 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRNAAA
A
-----
V
-QQAR
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PQNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDLN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|431946.3.peg.1505
Escherichia coli SE15 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
KY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|749531.3.peg.4805
Escherichia coli MS 69-1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GN
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EE
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|670888.3.peg.74
Escherichia coli 1827-70 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
IWVET--
DNT
GN
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
KR
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAN
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
T
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PK
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|656379.3.peg.2055
Escherichia coli FVEC1302 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GN
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
EVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|656380.3.peg.3018
Escherichia coli FVEC1412 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GN
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
EVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|749549.3.peg.5227
Escherichia coli MS 198-1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GN
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
EVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|585056.7.peg.2059
Escherichia coli UMN026 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GN
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
EVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|749527.3.peg.4301
Escherichia coli MS 21-1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GN
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
G
N
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|656393.3.peg.2375
Escherichia coli H299 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|656408.3.peg.1726
Escherichia coli H591 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VIWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
T
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|679206.4.peg.1318
Escherichia coli MS 119-7 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VIWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
T
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|562.371.peg.4430
Escherichia coli 1044A (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
E
Q
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
AWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNITRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKS
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|562.372.peg.4662
Escherichia coli 1212A (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
E
Q
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
AWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNITRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKS
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|562.374.peg.4447
Escherichia coli 536A (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
E
Q
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
AWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNITRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKS
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|83334.1.peg.2322
Escherichia coli O157:H7 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
E
Q
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
AWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNITRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKS
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|155864.1.peg.2330
Escherichia coli O157:H7 EDL933 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
E
Q
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
AWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNITRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKS
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|155864.8.peg.2169
Escherichia coli O157:H7 EDL933 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
E
Q
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
AWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNITRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKS
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|444454.5.peg.5571
Escherichia coli O157:H7 str. EC4024 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
E
Q
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
AWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNITRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKS
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|444449.5.peg.517
Escherichia coli O157:H7 str. EC4042 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
E
Q
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
AWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNITRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKS
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|444448.5.peg.4825
Escherichia coli O157:H7 str. EC4045 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
E
Q
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
AWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNITRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKS
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|444453.5.peg.4690
Escherichia coli O157:H7 str. EC4076 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
E
Q
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
AWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNITRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKS
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|444452.5.peg.3536
Escherichia coli O157:H7 str. EC4113 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
E
Q
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
AWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNITRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKS
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|444450.8.peg.2337
Escherichia coli O157:H7 str. EC4115 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
E
Q
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
AWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNITRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKS
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|444451.5.peg.3357
Escherichia coli O157:H7 str. EC4196 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
E
Q
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
AWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNITRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKS
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|444447.5.peg.5164
Escherichia coli O157:H7 str. EC4206 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
E
Q
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
AWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNITRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKS
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|478004.5.peg.4148
Escherichia coli O157:H7 str. EC4401 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
E
Q
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
AWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNITRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKS
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|478006.5.peg.4087
Escherichia coli O157:H7 str. EC4501 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
E
Q
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
AWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNITRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKS
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|478007.5.peg.3501
Escherichia coli O157:H7 str. EC508 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
E
Q
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
AWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNITRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKS
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|478008.5.peg.4497
Escherichia coli O157:H7 str. EC869 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
E
Q
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
AWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNITRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKS
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|637388.3.peg.5057
Escherichia coli O157:H7 str. FRIK2000 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
E
Q
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
AWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNITRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKS
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|570506.3.peg.4176
Escherichia coli O157:H7 str. FRIK966 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
E
Q
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
AWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNITRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKS
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|386585.9.peg.2401
Escherichia coli O157:H7 str. Sakai (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
E
Q
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
AWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNITRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKS
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|544404.4.peg.2200
Escherichia coli O157:H7 str. TW14359 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
E
Q
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
AWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNITRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKS
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|502346.5.peg.5112
Escherichia coli O157:H7 str. TW14588 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
E
Q
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
AWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNITRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKS
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|656417.3.peg.2077
Escherichia coli M605 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
KY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
HVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|331111.12.peg.2081
Escherichia coli E24377A (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VIWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
T
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IV
I
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|331111.3.peg.4224
Escherichia coli E24377A (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VIWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
T
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IV
I
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|216592.1.peg.2169
Escherichia coli 042 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
Y
E
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VE
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
SS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|216592.3.peg.1805
Escherichia coli 042 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
Y
E
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VE
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
SS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|331112.3.peg.1563
Escherichia coli HS (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
IWVET--
DNT
GN
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
T
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PK
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NF
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NISGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|331112.6.peg.1630
Escherichia coli HS (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
IWVET--
DNT
GN
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
T
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PK
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NF
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NISGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|413997.3.peg.1631
Escherichia coli B str. REL606 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
IWVET--
DNT
GN
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
D
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
T
CQ
GW
--
G
P
K
R
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|511693.5.peg.1656
Escherichia coli BL21 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
IWVET--
DNT
GN
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
D
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
T
CQ
GW
--
G
P
K
R
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|469008.4.peg.2118
Escherichia coli BL21(DE3) (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
IWVET--
DNT
GN
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
D
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
T
CQ
GW
--
G
P
K
R
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|562.373.peg.5332
Escherichia coli 1125A (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
E
Q
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
AWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNITRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKS
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
L
L
D
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|1040638.4.peg.3633
Escherichia coli O104:H4 str. LB226692 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VIWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
T
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VS
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|585055.6.peg.1782
Escherichia coli 55989 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VIWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
T
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VS
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|585055.8.peg.1786
Escherichia coli 55989 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VIWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
T
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VS
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|6666666.5357.peg.2358
Escherichia coli TY-2482 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VIWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
T
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VS
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDPPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|701177.3.peg.1978
Escherichia coli O55:H7 str. CB9615 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
E
Q
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
AWVET--
DNT
GS
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKS
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
C
GI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|358709.5.peg.1102
Escherichia coli 101-1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VVWGACSVN
CG
SR
C
A
L
C
L
H
V
K
D
NE
V
--------
IWVET--
DNT
GN
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
D
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PKNGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
T
CQ
GW
--
G
P
K
R
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
W
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWNSPERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDL
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|585057.4.peg.1537
Escherichia coli IAI39 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GN
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PINGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARELTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
R
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|585057.6.peg.1537
Escherichia coli IAI39 (10-808/808)
ISRR
T
L
V
K
S
TAIG
SL
A
L
A
AGGFS
LPF
T--LRSAAA
A
-----
V
-QQAS
EK
VVWGACSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
--------
TWVET--
DNT
GN
D
EY
-
G
N
HQVR
A
C
LR
G
RSIRR
R
I
NH
P
----
DRL
NY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQ
Y
SS
G
IV
G
GNMTRSSPSASA
-
VK
RLMN
CY
GG
SLN
----
QY
G
S
YS
T
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
GG
I
T
-----
YLLEKA
RE
K
SN
AK
M
-
I
V
IDP
R
Y
TD
T
AAGRE
DE
--
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAD
A
PINGH
YK
A
Y
IL
GEG
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLA
R
E
IGT
A
K
P
-
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARELTYTITIERL
P
--
V
L
-
D
N
PVKTS
IS
CFS
W
TD
A
IDH
G
PQ
MTA
IR-----
DGVR
---------
GK
DKL
D
VP
IK
FI
W
NY
A
G
N
TLVNQ
H
S
DIN
KTHE
-----------------------
I
LQD
ES
K
C
E
M
IVVI
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYAG
NM
GYLIFLQ
P
VTSEK
FE
R
K
P
I
YWILS
E
V
AKRL
G
P
DVYQKF
TEGR
T
Q
EQ
R
L
Q
H
L
Y
--
A
KML
A
KD
P
A--
--------------------------------------------------------
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
L
AEIAR
TWEL
EKDEVIS
P
LPVYAST
FE
GWDSPERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YG
-
N
IDV
L
KA
----
A
C
RQ
E
V
-
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SA
M
GQ
GAW
HE
A
NMSGDKIDHG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|679207.4.peg.2010
Escherichia coli MS 107-1 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PQ
WA
S
Q
ITG
I
P
AE
KI
I
Q
LA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|409438.11.peg.1082
Escherichia coli SE11 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PQ
WA
S
Q
ITG
I
P
AE
KI
I
Q
LA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|679205.4.peg.1027
Escherichia coli MS 124-1 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PQ
WA
S
Q
ITG
I
P
AE
KI
I
Q
LA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NT
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749533.3.peg.1023
Escherichia coli MS 84-1 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PQ
WA
S
Q
ITG
I
P
AE
KI
I
Q
LA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NT
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|216592.1.peg.227
Escherichia coli 042 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AV
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|358709.5.peg.3408
Escherichia coli 101-1 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|670888.3.peg.1509
Escherichia coli 1827-70 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|344610.3.peg.3941
Escherichia coli 53638 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|344610.7.peg.770
Escherichia coli 53638 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|481805.3.peg.2902
Escherichia coli ATCC 8739 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|550676.3.peg.362
Escherichia coli B185 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|536056.3.peg.2902
Escherichia coli DH1 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|316401.4.peg.1107
Escherichia coli ETEC H10407 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|656414.3.peg.1101
Escherichia coli H736 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|331112.3.peg.927
Escherichia coli HS (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|331112.6.peg.966
Escherichia coli HS (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|83333.1.peg.879
Escherichia coli K12 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749538.3.peg.2886
Escherichia coli MS 116-1 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749540.3.peg.2700
Escherichia coli MS 146-1 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749544.3.peg.632
Escherichia coli MS 175-1 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749547.3.peg.1841
Escherichia coli MS 187-1 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749548.3.peg.2260
Escherichia coli MS 196-1 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|316407.3.peg.860
Escherichia coli W3110 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|511145.12.peg.924
Escherichia coli str. K-12 substr. MG1655 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|344601.3.peg.2709
Escherichia coli B171 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|340185.3.peg.3053
Escherichia coli E22 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|340185.4.peg.3218
Escherichia coli E22 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749545.3.peg.4319
Escherichia coli MS 182-1 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749531.3.peg.2922
Escherichia coli MS 69-1 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749532.3.peg.782
Escherichia coli MS 78-1 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|585395.4.peg.987
Escherichia coli O103:H2 str. 12009 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|656444.3.peg.1511
Escherichia coli TA280 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|340184.3.peg.2686
Escherichia coli B7A (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|340184.6.peg.2809
Escherichia coli B7A (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|562.375.peg.4543
Escherichia coli EC4100B (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|595495.4.peg.3357
Escherichia coli KO11 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|679204.3.peg.2432
Escherichia coli MS 145-7 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|585396.4.peg.1002
Escherichia coli O111:H- str. 11128 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|566546.3.peg.1883
Escherichia coli W (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|566546.4.peg.992
Escherichia coli W (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|656379.3.peg.1743
Escherichia coli FVEC1302 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
Q
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|656380.3.peg.1571
Escherichia coli FVEC1412 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
Q
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749549.3.peg.5326
Escherichia coli MS 198-1 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
Q
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|585056.7.peg.1282
Escherichia coli UMN026 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
Q
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|656417.3.peg.1134
Escherichia coli M605 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
IIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|1040638.4.peg.4742
Escherichia coli O104:H4 str. LB226692 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NT
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|6666666.5357.peg.773
Escherichia coli TY-2482 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NT
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|585055.8.peg.956
Escherichia coli 55989 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NT
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|656393.3.peg.1656
Escherichia coli H299 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
L
PAKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749527.3.peg.2432
Escherichia coli MS 21-1 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
L
PAKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|439855.10.peg.2382
Escherichia coli SMS-3-5 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
L
PAKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|562.371.peg.2141
Escherichia coli 1044A (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSG
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|562.373.peg.1124
Escherichia coli 1125A (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSG
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|562.372.peg.990
Escherichia coli 1212A (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSG
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|562.374.peg.2523
Escherichia coli 536A (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSG
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|83334.1.peg.1047
Escherichia coli O157:H7 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSG
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|444454.5.peg.5475
Escherichia coli O157:H7 str. EC4024 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSG
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|444449.5.peg.4408
Escherichia coli O157:H7 str. EC4042 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSG
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|444448.5.peg.3684
Escherichia coli O157:H7 str. EC4045 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSG
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|444453.5.peg.5057
Escherichia coli O157:H7 str. EC4076 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSG
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|444452.5.peg.4998
Escherichia coli O157:H7 str. EC4113 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSG
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|444450.8.peg.1141
Escherichia coli O157:H7 str. EC4115 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSG
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|444451.5.peg.3774
Escherichia coli O157:H7 str. EC4196 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSG
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|444447.5.peg.3891
Escherichia coli O157:H7 str. EC4206 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSG
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|478004.5.peg.3678
Escherichia coli O157:H7 str. EC4401 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSG
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|478006.5.peg.3407
Escherichia coli O157:H7 str. EC4501 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSG
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|478007.5.peg.4035
Escherichia coli O157:H7 str. EC508 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSG
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|478008.5.peg.2563
Escherichia coli O157:H7 str. EC869 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSG
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|637388.3.peg.4472
Escherichia coli O157:H7 str. FRIK2000 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSG
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|570506.3.peg.2034
Escherichia coli O157:H7 str. FRIK966 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSG
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|386585.9.peg.1096
Escherichia coli O157:H7 str. Sakai (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSG
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|544404.4.peg.1007
Escherichia coli O157:H7 str. TW14359 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSG
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|502346.5.peg.193
Escherichia coli O157:H7 str. TW14588 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSG
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|701177.3.peg.1112
Escherichia coli O55:H7 str. CB9615 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSG
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|679206.4.peg.3406
Escherichia coli MS 119-7 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PQ
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|656443.3.peg.1179
Escherichia coli TA271 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PQ
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|656419.3.peg.1188
Escherichia coli M718 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
K
S
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|340186.3.peg.3976
Escherichia coli E110019 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
LSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|331111.3.peg.3466
Escherichia coli E24377A (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MT
E
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|362663.8.peg.918
Escherichia coli 536 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QE
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
SN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|362663.9.peg.918
Escherichia coli 536 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QE
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
SN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|340197.3.peg.2200
Escherichia coli F11 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QE
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
SN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|340197.5.peg.2314
Escherichia coli F11 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QE
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
SN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749550.3.peg.2131
Escherichia coli MS 200-1 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QE
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
SN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|656437.3.peg.1030
Escherichia coli TA143 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
DVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|869729.3.peg.2789
Escherichia coli UM146 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749537.3.peg.4337
Escherichia coli MS 115-1 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
G
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|655817.3.peg.985
Escherichia coli ABU 83972 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
SN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|199310.1.peg.1003
Escherichia coli CFT073 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
SN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749528.3.peg.1712
Escherichia coli MS 45-1 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
SN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|753642.3.peg.709
Escherichia coli NC101 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
SN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|685038.3.peg.828
Escherichia coli O83:H1 str. NRG 857C (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
SN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|656440.3.peg.808
Escherichia coli TA206 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
SN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|562.376.peg.4705
Escherichia coli WV_060327 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
K
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
SN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|656408.3.peg.952
Escherichia coli H591 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PQ
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
K
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749546.3.peg.1788
Escherichia coli MS 185-1 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
I
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLXQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
SN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--TKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|670897.3.peg.4690
Escherichia coli 2362-75 (10-814/814)
LA
AE
V
SRR
G
L
V
K
T
TAIG
GL
A
M
A
SSALT
LPF
SRIAHAVDR
A
-----
I
PTKSD
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
G
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
----------
DE
K
TLSAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IV
A
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|155864.1.peg.1079
Escherichia coli O157:H7 EDL933
M
A
SSALT
LPF
SRIAHAVDS
A
-----
I
PTKSG
EK
VIWSACTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
--------
KYVET--
DNT
GD
D
NY
D
G
L
HQVR
A
C
LR
G
RSMRR
R
V
YN
P
----
DRL
KY
PM
K
R
V
G
A
---
RGEG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLN
Y
GT
G
TL
G
GTMTRSWPPGNT
L
VA
RLMN
CC
GG
YLN
----
HY
G
D
YS
S
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
GG
V
T
-----
YYLEQA
R
Q
K
SN
AR
M
-
I
I
IDP
R
Y
TD
T
GAGRE
DE
--
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
----------
DE
K
TLPAS
A
PKNGH
YK
A
Y
IL
GEG
P
D
GVA
KT
PE
WA
X
Q
ITGVP
AD
KI
I
KLA
R
E
IGS
T
K
P
-
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
--
T
L
-
E
N
PIQTS
IS
MFM
W
TD
A
IER
G
PE
MTA
LR-----
DGVR
---------
GK
DKL
D
VP
IK
MI
W
NY
A
G
N
CLINQ
H
S
E
IN
RTHE
-----------------------
I
LQD
DK
K
C
E
L
IVVID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASCG
NM
SYVIFND
Q
VIKPR
FE
C
K
T
I
YEMTS
E
L
AKRL
G
-
-VEQQF
TEGR
T
Q
EE
W
M
R
H
L
Y
--
A
QSR
E
AI
P
E--
--------------------------------------------------------
LP
T
FE
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
L
ADIAA
TWEL
PEGDVID
P
LPIYTPG
FE
SYQDPLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YG
-
N
VDV
L
KA
----
A
C
RQ
E
M
-
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VA
L
GE
GAW
YD
P
D--AKRVDKG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|562.373.peg.3712
Escherichia coli 1125A (14-792/793)
QV
SRR
S
F
LQ
A
T
---
--
-
-
-
SALIT
LPF
ISSTAKAQS
P
DASPE
V
TAPVA
D
K
VVPTCSTFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
--------
TQITTLP
DN
E
LD
P
QM
-
-
-
PI
M
R
A
C
VR
G
RGYRK
F
V
YH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVH
V
GT
A
VS
G
GTFS-----GDA
M
AR
RL
L
N
LT
GG
YLE
----
YY
H
S
V
S
L
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
G
H
T
N
-----
YYFQKM
K
Q
-
N
G
TR
F
-
I
V
V
DP
R
Y
SD
T
VSSLA
D
Q
--
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
----------
DE
N
SMPEG
V
PANES
LV
A
Y
LF
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LA
R
D
YAT
T
K
P
-
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
--
D
M
P
E
N
PVQAK
IS
IMN
W
MQ
A
ADD
A
SK
V
T
P
-Q-----
DG
L
K
---------
G
V
DKL
D
SN
I
R
LL
F
SL
A
G
N
YLANQ
N
P
D
VH
QAAK
-----------------------
L
L
E
D
ES
K
I
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETWG
T
A
SYLILSE
K
PIEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
L
G
-
-VEAEF
SQ
GR
D
E
KQ
W
I
E
H
I
W
--
E
QTR
L
AM
P
DEN
--------------------------------------------------------
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
FDM--
----
-QDPEIP
A
LSHYVPA
FE
GPEDKLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YA
-
N
-PW
L
QE
----
V
Q
T
Q
K
L
-
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VA
M
QA
GAW
WQ
P
D--AQGIDRG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|83334.1.peg.3383
Escherichia coli O157:H7 (14-792/793)
QV
SRR
S
F
LQ
A
T
---
--
-
-
-
SALIT
LPF
ISSTAKAQS
P
DASPE
V
TAPVA
D
K
VVPTCSTFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
--------
TQITTLP
DN
E
LD
P
QM
-
-
-
PI
M
R
A
C
VR
G
RGYRK
F
V
YH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVH
V
GT
A
VS
G
GTFS-----GDA
M
AR
RL
L
N
LT
GG
YLE
----
YY
H
S
V
S
L
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
G
H
T
N
-----
YYFQKM
K
Q
-
N
G
TR
F
-
I
V
V
DP
R
Y
SD
T
VSSLA
D
Q
--
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
----------
DE
N
SMPEG
V
PANES
LV
A
Y
LF
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LA
R
D
YAT
T
K
P
-
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
--
D
M
P
E
N
PVQAK
IS
IMN
W
MQ
A
ADD
A
SK
V
T
P
-Q-----
DG
L
K
---------
G
V
DKL
D
SN
I
R
LL
F
SL
A
G
N
YLANQ
N
P
D
VH
QAAK
-----------------------
L
L
E
D
ES
K
I
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETWG
T
A
SYLILSE
K
PIEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
L
G
-
-VEAEF
SQ
GR
D
E
KQ
W
I
E
H
I
W
--
E
QTR
L
AM
P
DEN
--------------------------------------------------------
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
FDM--
----
-QDPEIP
A
LSHYVPA
FE
GPEDKLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YA
-
N
-PW
L
QE
----
V
Q
T
Q
K
L
-
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VA
M
QA
GAW
WQ
P
D--AQGIDRG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|444454.5.peg.2406
Escherichia coli O157:H7 str. EC4024 (14-792/793)
QV
SRR
S
F
LQ
A
T
---
--
-
-
-
SALIT
LPF
ISSTAKAQS
P
DASPE
V
TAPVA
D
K
VVPTCSTFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
--------
TQITTLP
DN
E
LD
P
QM
-
-
-
PI
M
R
A
C
VR
G
RGYRK
F
V
YH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVH
V
GT
A
VS
G
GTFS-----GDA
M
AR
RL
L
N
LT
GG
YLE
----
YY
H
S
V
S
L
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
G
H
T
N
-----
YYFQKM
K
Q
-
N
G
TR
F
-
I
V
V
DP
R
Y
SD
T
VSSLA
D
Q
--
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
----------
DE
N
SMPEG
V
PANES
LV
A
Y
LF
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LA
R
D
YAT
T
K
P
-
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
--
D
M
P
E
N
PVQAK
IS
IMN
W
MQ
A
ADD
A
SK
V
T
P
-Q-----
DG
L
K
---------
G
V
DKL
D
SN
I
R
LL
F
SL
A
G
N
YLANQ
N
P
D
VH
QAAK
-----------------------
L
L
E
D
ES
K
I
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETWG
T
A
SYLILSE
K
PIEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
L
G
-
-VEAEF
SQ
GR
D
E
KQ
W
I
E
H
I
W
--
E
QTR
L
AM
P
DEN
--------------------------------------------------------
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
FDM--
----
-QDPEIP
A
LSHYVPA
FE
GPEDKLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YA
-
N
-PW
L
QE
----
V
Q
T
Q
K
L
-
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VA
M
QA
GAW
WQ
P
D--AQGIDRG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|444449.5.peg.1872
Escherichia coli O157:H7 str. EC4042 (14-792/793)
QV
SRR
S
F
LQ
A
T
---
--
-
-
-
SALIT
LPF
ISSTAKAQS
P
DASPE
V
TAPVA
D
K
VVPTCSTFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
--------
TQITTLP
DN
E
LD
P
QM
-
-
-
PI
M
R
A
C
VR
G
RGYRK
F
V
YH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVH
V
GT
A
VS
G
GTFS-----GDA
M
AR
RL
L
N
LT
GG
YLE
----
YY
H
S
V
S
L
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
G
H
T
N
-----
YYFQKM
K
Q
-
N
G
TR
F
-
I
V
V
DP
R
Y
SD
T
VSSLA
D
Q
--
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
----------
DE
N
SMPEG
V
PANES
LV
A
Y
LF
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LA
R
D
YAT
T
K
P
-
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
--
D
M
P
E
N
PVQAK
IS
IMN
W
MQ
A
ADD
A
SK
V
T
P
-Q-----
DG
L
K
---------
G
V
DKL
D
SN
I
R
LL
F
SL
A
G
N
YLANQ
N
P
D
VH
QAAK
-----------------------
L
L
E
D
ES
K
I
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETWG
T
A
SYLILSE
K
PIEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
L
G
-
-VEAEF
SQ
GR
D
E
KQ
W
I
E
H
I
W
--
E
QTR
L
AM
P
DEN
--------------------------------------------------------
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
FDM--
----
-QDPEIP
A
LSHYVPA
FE
GPEDKLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YA
-
N
-PW
L
QE
----
V
Q
T
Q
K
L
-
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VA
M
QA
GAW
WQ
P
D--AQGIDRG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|444448.5.peg.626
Escherichia coli O157:H7 str. EC4045 (14-792/793)
QV
SRR
S
F
LQ
A
T
---
--
-
-
-
SALIT
LPF
ISSTAKAQS
P
DASPE
V
TAPVA
D
K
VVPTCSTFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
--------
TQITTLP
DN
E
LD
P
QM
-
-
-
PI
M
R
A
C
VR
G
RGYRK
F
V
YH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVH
V
GT
A
VS
G
GTFS-----GDA
M
AR
RL
L
N
LT
GG
YLE
----
YY
H
S
V
S
L
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
G
H
T
N
-----
YYFQKM
K
Q
-
N
G
TR
F
-
I
V
V
DP
R
Y
SD
T
VSSLA
D
Q
--
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
----------
DE
N
SMPEG
V
PANES
LV
A
Y
LF
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LA
R
D
YAT
T
K
P
-
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
--
D
M
P
E
N
PVQAK
IS
IMN
W
MQ
A
ADD
A
SK
V
T
P
-Q-----
DG
L
K
---------
G
V
DKL
D
SN
I
R
LL
F
SL
A
G
N
YLANQ
N
P
D
VH
QAAK
-----------------------
L
L
E
D
ES
K
I
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETWG
T
A
SYLILSE
K
PIEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
L
G
-
-VEAEF
SQ
GR
D
E
KQ
W
I
E
H
I
W
--
E
QTR
L
AM
P
DEN
--------------------------------------------------------
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
FDM--
----
-QDPEIP
A
LSHYVPA
FE
GPEDKLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YA
-
N
-PW
L
QE
----
V
Q
T
Q
K
L
-
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VA
M
QA
GAW
WQ
P
D--AQGIDRG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|444453.5.peg.107
Escherichia coli O157:H7 str. EC4076 (14-792/793)
QV
SRR
S
F
LQ
A
T
---
--
-
-
-
SALIT
LPF
ISSTAKAQS
P
DASPE
V
TAPVA
D
K
VVPTCSTFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
--------
TQITTLP
DN
E
LD
P
QM
-
-
-
PI
M
R
A
C
VR
G
RGYRK
F
V
YH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVH
V
GT
A
VS
G
GTFS-----GDA
M
AR
RL
L
N
LT
GG
YLE
----
YY
H
S
V
S
L
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
G
H
T
N
-----
YYFQKM
K
Q
-
N
G
TR
F
-
I
V
V
DP
R
Y
SD
T
VSSLA
D
Q
--
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
----------
DE
N
SMPEG
V
PANES
LV
A
Y
LF
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LA
R
D
YAT
T
K
P
-
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
--
D
M
P
E
N
PVQAK
IS
IMN
W
MQ
A
ADD
A
SK
V
T
P
-Q-----
DG
L
K
---------
G
V
DKL
D
SN
I
R
LL
F
SL
A
G
N
YLANQ
N
P
D
VH
QAAK
-----------------------
L
L
E
D
ES
K
I
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETWG
T
A
SYLILSE
K
PIEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
L
G
-
-VEAEF
SQ
GR
D
E
KQ
W
I
E
H
I
W
--
E
QTR
L
AM
P
DEN
--------------------------------------------------------
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
FDM--
----
-QDPEIP
A
LSHYVPA
FE
GPEDKLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YA
-
N
-PW
L
QE
----
V
Q
T
Q
K
L
-
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VA
M
QA
GAW
WQ
P
D--AQGIDRG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|444452.5.peg.1484
Escherichia coli O157:H7 str. EC4113 (14-792/793)
QV
SRR
S
F
LQ
A
T
---
--
-
-
-
SALIT
LPF
ISSTAKAQS
P
DASPE
V
TAPVA
D
K
VVPTCSTFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
--------
TQITTLP
DN
E
LD
P
QM
-
-
-
PI
M
R
A
C
VR
G
RGYRK
F
V
YH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVH
V
GT
A
VS
G
GTFS-----GDA
M
AR
RL
L
N
LT
GG
YLE
----
YY
H
S
V
S
L
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
G
H
T
N
-----
YYFQKM
K
Q
-
N
G
TR
F
-
I
V
V
DP
R
Y
SD
T
VSSLA
D
Q
--
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
----------
DE
N
SMPEG
V
PANES
LV
A
Y
LF
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LA
R
D
YAT
T
K
P
-
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
--
D
M
P
E
N
PVQAK
IS
IMN
W
MQ
A
ADD
A
SK
V
T
P
-Q-----
DG
L
K
---------
G
V
DKL
D
SN
I
R
LL
F
SL
A
G
N
YLANQ
N
P
D
VH
QAAK
-----------------------
L
L
E
D
ES
K
I
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETWG
T
A
SYLILSE
K
PIEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
L
G
-
-VEAEF
SQ
GR
D
E
KQ
W
I
E
H
I
W
--
E
QTR
L
AM
P
DEN
--------------------------------------------------------
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
FDM--
----
-QDPEIP
A
LSHYVPA
FE
GPEDKLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YA
-
N
-PW
L
QE
----
V
Q
T
Q
K
L
-
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VA
M
QA
GAW
WQ
P
D--AQGIDRG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|444450.8.peg.3715
Escherichia coli O157:H7 str. EC4115 (14-792/793)
QV
SRR
S
F
LQ
A
T
---
--
-
-
-
SALIT
LPF
ISSTAKAQS
P
DASPE
V
TAPVA
D
K
VVPTCSTFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
--------
TQITTLP
DN
E
LD
P
QM
-
-
-
PI
M
R
A
C
VR
G
RGYRK
F
V
YH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVH
V
GT
A
VS
G
GTFS-----GDA
M
AR
RL
L
N
LT
GG
YLE
----
YY
H
S
V
S
L
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
G
H
T
N
-----
YYFQKM
K
Q
-
N
G
TR
F
-
I
V
V
DP
R
Y
SD
T
VSSLA
D
Q
--
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
----------
DE
N
SMPEG
V
PANES
LV
A
Y
LF
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LA
R
D
YAT
T
K
P
-
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
--
D
M
P
E
N
PVQAK
IS
IMN
W
MQ
A
ADD
A
SK
V
T
P
-Q-----
DG
L
K
---------
G
V
DKL
D
SN
I
R
LL
F
SL
A
G
N
YLANQ
N
P
D
VH
QAAK
-----------------------
L
L
E
D
ES
K
I
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETWG
T
A
SYLILSE
K
PIEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
L
G
-
-VEAEF
SQ
GR
D
E
KQ
W
I
E
H
I
W
--
E
QTR
L
AM
P
DEN
--------------------------------------------------------
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
FDM--
----
-QDPEIP
A
LSHYVPA
FE
GPEDKLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YA
-
N
-PW
L
QE
----
V
Q
T
Q
K
L
-
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VA
M
QA
GAW
WQ
P
D--AQGIDRG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|444451.5.peg.1254
Escherichia coli O157:H7 str. EC4196 (14-792/793)
QV
SRR
S
F
LQ
A
T
---
--
-
-
-
SALIT
LPF
ISSTAKAQS
P
DASPE
V
TAPVA
D
K
VVPTCSTFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
--------
TQITTLP
DN
E
LD
P
QM
-
-
-
PI
M
R
A
C
VR
G
RGYRK
F
V
YH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVH
V
GT
A
VS
G
GTFS-----GDA
M
AR
RL
L
N
LT
GG
YLE
----
YY
H
S
V
S
L
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
G
H
T
N
-----
YYFQKM
K
Q
-
N
G
TR
F
-
I
V
V
DP
R
Y
SD
T
VSSLA
D
Q
--
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
----------
DE
N
SMPEG
V
PANES
LV
A
Y
LF
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LA
R
D
YAT
T
K
P
-
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
--
D
M
P
E
N
PVQAK
IS
IMN
W
MQ
A
ADD
A
SK
V
T
P
-Q-----
DG
L
K
---------
G
V
DKL
D
SN
I
R
LL
F
SL
A
G
N
YLANQ
N
P
D
VH
QAAK
-----------------------
L
L
E
D
ES
K
I
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETWG
T
A
SYLILSE
K
PIEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
L
G
-
-VEAEF
SQ
GR
D
E
KQ
W
I
E
H
I
W
--
E
QTR
L
AM
P
DEN
--------------------------------------------------------
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
FDM--
----
-QDPEIP
A
LSHYVPA
FE
GPEDKLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YA
-
N
-PW
L
QE
----
V
Q
T
Q
K
L
-
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VA
M
QA
GAW
WQ
P
D--AQGIDRG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|444447.5.peg.767
Escherichia coli O157:H7 str. EC4206 (14-792/793)
QV
SRR
S
F
LQ
A
T
---
--
-
-
-
SALIT
LPF
ISSTAKAQS
P
DASPE
V
TAPVA
D
K
VVPTCSTFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
--------
TQITTLP
DN
E
LD
P
QM
-
-
-
PI
M
R
A
C
VR
G
RGYRK
F
V
YH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVH
V
GT
A
VS
G
GTFS-----GDA
M
AR
RL
L
N
LT
GG
YLE
----
YY
H
S
V
S
L
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
G
H
T
N
-----
YYFQKM
K
Q
-
N
G
TR
F
-
I
V
V
DP
R
Y
SD
T
VSSLA
D
Q
--
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
----------
DE
N
SMPEG
V
PANES
LV
A
Y
LF
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LA
R
D
YAT
T
K
P
-
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
--
D
M
P
E
N
PVQAK
IS
IMN
W
MQ
A
ADD
A
SK
V
T
P
-Q-----
DG
L
K
---------
G
V
DKL
D
SN
I
R
LL
F
SL
A
G
N
YLANQ
N
P
D
VH
QAAK
-----------------------
L
L
E
D
ES
K
I
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETWG
T
A
SYLILSE
K
PIEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
L
G
-
-VEAEF
SQ
GR
D
E
KQ
W
I
E
H
I
W
--
E
QTR
L
AM
P
DEN
--------------------------------------------------------
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
FDM--
----
-QDPEIP
A
LSHYVPA
FE
GPEDKLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YA
-
N
-PW
L
QE
----
V
Q
T
Q
K
L
-
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VA
M
QA
GAW
WQ
P
D--AQGIDRG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|478004.5.peg.3027
Escherichia coli O157:H7 str. EC4401 (14-792/793)
QV
SRR
S
F
LQ
A
T
---
--
-
-
-
SALIT
LPF
ISSTAKAQS
P
DASPE
V
TAPVA
D
K
VVPTCSTFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
--------
TQITTLP
DN
E
LD
P
QM
-
-
-
PI
M
R
A
C
VR
G
RGYRK
F
V
YH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVH
V
GT
A
VS
G
GTFS-----GDA
M
AR
RL
L
N
LT
GG
YLE
----
YY
H
S
V
S
L
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
G
H
T
N
-----
YYFQKM
K
Q
-
N
G
TR
F
-
I
V
V
DP
R
Y
SD
T
VSSLA
D
Q
--
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
----------
DE
N
SMPEG
V
PANES
LV
A
Y
LF
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LA
R
D
YAT
T
K
P
-
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
--
D
M
P
E
N
PVQAK
IS
IMN
W
MQ
A
ADD
A
SK
V
T
P
-Q-----
DG
L
K
---------
G
V
DKL
D
SN
I
R
LL
F
SL
A
G
N
YLANQ
N
P
D
VH
QAAK
-----------------------
L
L
E
D
ES
K
I
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETWG
T
A
SYLILSE
K
PIEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
L
G
-
-VEAEF
SQ
GR
D
E
KQ
W
I
E
H
I
W
--
E
QTR
L
AM
P
DEN
--------------------------------------------------------
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
FDM--
----
-QDPEIP
A
LSHYVPA
FE
GPEDKLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YA
-
N
-PW
L
QE
----
V
Q
T
Q
K
L
-
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VA
M
QA
GAW
WQ
P
D--AQGIDRG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|478005.5.peg.2597
Escherichia coli O157:H7 str. EC4486 (14-792/793)
QV
SRR
S
F
LQ
A
T
---
--
-
-
-
SALIT
LPF
ISSTAKAQS
P
DASPE
V
TAPVA
D
K
VVPTCSTFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
--------
TQITTLP
DN
E
LD
P
QM
-
-
-
PI
M
R
A
C
VR
G
RGYRK
F
V
YH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVH
V
GT
A
VS
G
GTFS-----GDA
M
AR
RL
L
N
LT
GG
YLE
----
YY
H
S
V
S
L
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
G
H
T
N
-----
YYFQKM
K
Q
-
N
G
TR
F
-
I
V
V
DP
R
Y
SD
T
VSSLA
D
Q
--
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
----------
DE
N
SMPEG
V
PANES
LV
A
Y
LF
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LA
R
D
YAT
T
K
P
-
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
--
D
M
P
E
N
PVQAK
IS
IMN
W
MQ
A
ADD
A
SK
V
T
P
-Q-----
DG
L
K
---------
G
V
DKL
D
SN
I
R
LL
F
SL
A
G
N
YLANQ
N
P
D
VH
QAAK
-----------------------
L
L
E
D
ES
K
I
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETWG
T
A
SYLILSE
K
PIEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
L
G
-
-VEAEF
SQ
GR
D
E
KQ
W
I
E
H
I
W
--
E
QTR
L
AM
P
DEN
--------------------------------------------------------
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
FDM--
----
-QDPEIP
A
LSHYVPA
FE
GPEDKLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YA
-
N
-PW
L
QE
----
V
Q
T
Q
K
L
-
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VA
M
QA
GAW
WQ
P
D--AQGIDRG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|478006.5.peg.1636
Escherichia coli O157:H7 str. EC4501 (14-792/793)
QV
SRR
S
F
LQ
A
T
---
--
-
-
-
SALIT
LPF
ISSTAKAQS
P
DASPE
V
TAPVA
D
K
VVPTCSTFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
--------
TQITTLP
DN
E
LD
P
QM
-
-
-
PI
M
R
A
C
VR
G
RGYRK
F
V
YH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVH
V
GT
A
VS
G
GTFS-----GDA
M
AR
RL
L
N
LT
GG
YLE
----
YY
H
S
V
S
L
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
G
H
T
N
-----
YYFQKM
K
Q
-
N
G
TR
F
-
I
V
V
DP
R
Y
SD
T
VSSLA
D
Q
--
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
----------
DE
N
SMPEG
V
PANES
LV
A
Y
LF
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LA
R
D
YAT
T
K
P
-
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
--
D
M
P
E
N
PVQAK
IS
IMN
W
MQ
A
ADD
A
SK
V
T
P
-Q-----
DG
L
K
---------
G
V
DKL
D
SN
I
R
LL
F
SL
A
G
N
YLANQ
N
P
D
VH
QAAK
-----------------------
L
L
E
D
ES
K
I
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETWG
T
A
SYLILSE
K
PIEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
L
G
-
-VEAEF
SQ
GR
D
E
KQ
W
I
E
H
I
W
--
E
QTR
L
AM
P
DEN
--------------------------------------------------------
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
FDM--
----
-QDPEIP
A
LSHYVPA
FE
GPEDKLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YA
-
N
-PW
L
QE
----
V
Q
T
Q
K
L
-
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VA
M
QA
GAW
WQ
P
D--AQGIDRG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|478007.5.peg.1680
Escherichia coli O157:H7 str. EC508 (14-792/793)
QV
SRR
S
F
LQ
A
T
---
--
-
-
-
SALIT
LPF
ISSTAKAQS
P
DASPE
V
TAPVA
D
K
VVPTCSTFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
--------
TQITTLP
DN
E
LD
P
QM
-
-
-
PI
M
R
A
C
VR
G
RGYRK
F
V
YH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVH
V
GT
A
VS
G
GTFS-----GDA
M
AR
RL
L
N
LT
GG
YLE
----
YY
H
S
V
S
L
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
G
H
T
N
-----
YYFQKM
K
Q
-
N
G
TR
F
-
I
V
V
DP
R
Y
SD
T
VSSLA
D
Q
--
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
----------
DE
N
SMPEG
V
PANES
LV
A
Y
LF
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LA
R
D
YAT
T
K
P
-
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
--
D
M
P
E
N
PVQAK
IS
IMN
W
MQ
A
ADD
A
SK
V
T
P
-Q-----
DG
L
K
---------
G
V
DKL
D
SN
I
R
LL
F
SL
A
G
N
YLANQ
N
P
D
VH
QAAK
-----------------------
L
L
E
D
ES
K
I
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETWG
T
A
SYLILSE
K
PIEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
L
G
-
-VEAEF
SQ
GR
D
E
KQ
W
I
E
H
I
W
--
E
QTR
L
AM
P
DEN
--------------------------------------------------------
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
FDM--
----
-QDPEIP
A
LSHYVPA
FE
GPEDKLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YA
-
N
-PW
L
QE
----
V
Q
T
Q
K
L
-
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VA
M
QA
GAW
WQ
P
D--AQGIDRG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|386585.9.peg.3535
Escherichia coli O157:H7 str. Sakai (14-792/793)
QV
SRR
S
F
LQ
A
T
---
--
-
-
-
SALIT
LPF
ISSTAKAQS
P
DASPE
V
TAPVA
D
K
VVPTCSTFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
--------
TQITTLP
DN
E
LD
P
QM
-
-
-
PI
M
R
A
C
VR
G
RGYRK
F
V
YH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVH
V
GT
A
VS
G
GTFS-----GDA
M
AR
RL
L
N
LT
GG
YLE
----
YY
H
S
V
S
L
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
G
H
T
N
-----
YYFQKM
K
Q
-
N
G
TR
F
-
I
V
V
DP
R
Y
SD
T
VSSLA
D
Q
--
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
----------
DE
N
SMPEG
V
PANES
LV
A
Y
LF
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LA
R
D
YAT
T
K
P
-
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
--
D
M
P
E
N
PVQAK
IS
IMN
W
MQ
A
ADD
A
SK
V
T
P
-Q-----
DG
L
K
---------
G
V
DKL
D
SN
I
R
LL
F
SL
A
G
N
YLANQ
N
P
D
VH
QAAK
-----------------------
L
L
E
D
ES
K
I
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETWG
T
A
SYLILSE
K
PIEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
L
G
-
-VEAEF
SQ
GR
D
E
KQ
W
I
E
H
I
W
--
E
QTR
L
AM
P
DEN
--------------------------------------------------------
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
FDM--
----
-QDPEIP
A
LSHYVPA
FE
GPEDKLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YA
-
N
-PW
L
QE
----
V
Q
T
Q
K
L
-
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VA
M
QA
GAW
WQ
P
D--AQGIDRG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|544404.4.peg.3518
Escherichia coli O157:H7 str. TW14359 (14-792/793)
QV
SRR
S
F
LQ
A
T
---
--
-
-
-
SALIT
LPF
ISSTAKAQS
P
DASPE
V
TAPVA
D
K
VVPTCSTFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
--------
TQITTLP
DN
E
LD
P
QM
-
-
-
PI
M
R
A
C
VR
G
RGYRK
F
V
YH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVH
V
GT
A
VS
G
GTFS-----GDA
M
AR
RL
L
N
LT
GG
YLE
----
YY
H
S
V
S
L
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
G
H
T
N
-----
YYFQKM
K
Q
-
N
G
TR
F
-
I
V
V
DP
R
Y
SD
T
VSSLA
D
Q
--
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
----------
DE
N
SMPEG
V
PANES
LV
A
Y
LF
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LA
R
D
YAT
T
K
P
-
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
--
D
M
P
E
N
PVQAK
IS
IMN
W
MQ
A
ADD
A
SK
V
T
P
-Q-----
DG
L
K
---------
G
V
DKL
D
SN
I
R
LL
F
SL
A
G
N
YLANQ
N
P
D
VH
QAAK
-----------------------
L
L
E
D
ES
K
I
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETWG
T
A
SYLILSE
K
PIEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
L
G
-
-VEAEF
SQ
GR
D
E
KQ
W
I
E
H
I
W
--
E
QTR
L
AM
P
DEN
--------------------------------------------------------
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
FDM--
----
-QDPEIP
A
LSHYVPA
FE
GPEDKLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YA
-
N
-PW
L
QE
----
V
Q
T
Q
K
L
-
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VA
M
QA
GAW
WQ
P
D--AQGIDRG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|502346.5.peg.3897
Escherichia coli O157:H7 str. TW14588 (14-792/793)
QV
SRR
S
F
LQ
A
T
---
--
-
-
-
SALIT
LPF
ISSTAKAQS
P
DASPE
V
TAPVA
D
K
VVPTCSTFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
--------
TQITTLP
DN
E
LD
P
QM
-
-
-
PI
M
R
A
C
VR
G
RGYRK
F
V
YH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVH
V
GT
A
VS
G
GTFS-----GDA
M
AR
RL
L
N
LT
GG
YLE
----
YY
H
S
V
S
L
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
G
H
T
N
-----
YYFQKM
K
Q
-
N
G
TR
F
-
I
V
V
DP
R
Y
SD
T
VSSLA
D
Q
--
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
----------
DE
N
SMPEG
V
PANES
LV
A
Y
LF
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LA
R
D
YAT
T
K
P
-
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
--
D
M
P
E
N
PVQAK
IS
IMN
W
MQ
A
ADD
A
SK
V
T
P
-Q-----
DG
L
K
---------
G
V
DKL
D
SN
I
R
LL
F
SL
A
G
N
YLANQ
N
P
D
VH
QAAK
-----------------------
L
L
E
D
ES
K
I
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETWG
T
A
SYLILSE
K
PIEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
L
G
-
-VEAEF
SQ
GR
D
E
KQ
W
I
E
H
I
W
--
E
QTR
L
AM
P
DEN
--------------------------------------------------------
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
FDM--
----
-QDPEIP
A
LSHYVPA
FE
GPEDKLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YA
-
N
-PW
L
QE
----
V
Q
T
Q
K
L
-
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VA
M
QA
GAW
WQ
P
D--AQGIDRG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|478008.5.peg.3072
Escherichia coli O157:H7 str. EC869 (14-792/793)
QV
SRR
S
F
LQ
A
T
---
--
-
-
-
SALIT
LPF
ISSTAKAQS
P
DASPE
V
TAPVA
D
K
VVPTCSTFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
--------
TQITTLP
DN
E
LD
P
QM
-
-
-
PI
M
R
A
C
VR
G
RGYRK
F
V
YH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVH
V
GT
A
VS
G
GTFS-----GDA
M
AR
RL
L
N
LT
GG
YLE
----
YY
H
S
V
S
L
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
G
H
T
N
-----
YYFQKM
K
Q
-
N
G
TR
F
-
I
V
V
DP
R
Y
SD
T
VSSLA
D
Q
--
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
----------
DE
N
SMPEG
V
PANES
LV
A
Y
LF
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LA
R
D
YAT
T
K
P
-
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
--
D
M
P
E
N
PVQAK
IS
IMN
W
MQ
A
ADD
A
SK
V
T
P
-Q-----
DG
L
K
---------
G
V
DKL
D
SN
I
R
LL
F
SL
A
G
N
YLANQ
N
P
D
VH
QAAK
-----------------------
L
L
E
D
ES
K
I
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETWG
T
A
SYLILSE
K
LIEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
L
G
-
-VEAEF
SQ
GR
D
E
KQ
W
I
E
H
I
W
--
E
QTR
L
AM
P
DEN
--------------------------------------------------------
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
FDM--
----
-QDPEIP
A
LSHYVPA
FE
GPEDKLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YA
-
N
-PW
L
QE
----
V
Q
T
Q
K
L
-
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VA
M
QA
GAW
WQ
P
D--AQGIDRG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|637388.3.peg.75
Escherichia coli O157:H7 str. FRIK2000 (14-792/793)
QV
SRR
S
F
LQ
A
T
---
--
-
-
-
SALIT
LPF
ISSTAKAQS
P
DASPE
V
TAPVA
D
K
VVPTCSTFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
--------
TQITTLP
DN
E
LD
P
QM
-
-
-
PI
M
R
A
C
VR
G
RGYRK
F
V
YH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVH
V
GT
A
VS
G
GTFS-----GDA
M
AR
RL
L
N
LT
GG
YLE
----
YY
H
S
V
S
L
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
G
H
T
N
-----
YYFQKM
K
Q
-
N
G
TR
F
-
I
V
V
DP
R
Y
SD
T
VSSLA
D
Q
--
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
----------
DE
N
SMPEG
V
PANES
LV
A
Y
LF
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LA
R
D
YAT
T
K
P
-
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
--
D
M
P
E
N
PVQAK
IS
IMN
W
MQ
A
ADD
A
SK
V
T
P
-Q-----
DG
L
K
---------
G
V
DKL
D
SN
I
R
LL
F
SL
A
G
N
YLANQ
N
P
D
VH
QAAK
-----------------------
L
L
E
D
ES
K
I
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETWG
T
A
SYLILSE
K
LIEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
L
G
-
-VEAEF
SQ
GR
D
E
KQ
W
I
E
H
I
W
--
E
QTR
L
AM
P
DEN
--------------------------------------------------------
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
FDM--
----
-QDPEIP
A
LSHYVPA
FE
GPEDKLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YA
-
N
-PW
L
QE
----
V
Q
T
Q
K
L
-
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VA
M
QA
GAW
WQ
P
D--AQGIDRG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|570506.3.peg.5258
Escherichia coli O157:H7 str. FRIK966 (14-792/793)
QV
SRR
S
F
LQ
A
T
---
--
-
-
-
SALIT
LPF
ISSTAKAQS
P
DASPE
V
TAPVA
D
K
VVPTCSTFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
--------
TQITTLP
DN
E
LD
P
QM
-
-
-
PI
M
R
A
C
VR
G
RGYRK
F
V
YH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVH
V
GT
A
VS
G
GTFS-----GDA
M
AR
RL
L
N
LT
GG
YLE
----
YY
H
S
V
S
L
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
G
H
T
N
-----
YYFQKM
K
Q
-
N
G
TR
F
-
I
V
V
DP
R
Y
SD
T
VSSLA
D
Q
--
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
----------
DE
N
SMPEG
V
PANES
LV
A
Y
LF
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LA
R
D
YAT
T
K
P
-
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
--
D
M
P
E
N
PVQAK
IS
IMN
W
MQ
A
ADD
A
SK
V
T
P
-Q-----
DG
L
K
---------
G
V
DKL
D
SN
I
R
LL
F
SL
A
G
N
YLANQ
N
P
D
VH
QAAK
-----------------------
L
L
E
D
ES
K
I
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETWG
T
A
SYLILSE
K
LIEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
L
G
-
-VEAEF
SQ
GR
D
E
KQ
W
I
E
H
I
W
--
E
QTR
L
AM
P
DEN
--------------------------------------------------------
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
FDM--
----
-QDPEIP
A
LSHYVPA
FE
GPEDKLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YA
-
N
-PW
L
QE
----
V
Q
T
Q
K
L
-
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VA
M
QA
GAW
WQ
P
D--AQGIDRG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|155864.1.peg.3383
Escherichia coli O157:H7 EDL933 (14-792/793)
QV
SRR
S
F
LQ
A
T
---
--
-
-
-
SALIT
LPF
ISSTAKAQS
P
DASPE
V
TAPVA
D
K
VVPTCSTFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
--------
TQITTLP
DN
E
LD
P
QM
-
-
-
PI
M
R
A
C
VR
G
RGYRK
F
V
YH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVH
V
GT
A
VX
G
GTFS-----GDA
M
AR
RL
L
N
LT
GG
YLE
----
YY
H
S
V
S
L
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
G
H
T
N
-----
YYFQKM
K
Q
-
N
G
TR
F
-
I
V
V
DP
R
Y
SD
T
VSSLA
D
Q
--
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
----------
DE
N
SMPEG
V
PANES
LV
A
Y
LF
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LA
R
D
YAT
T
K
P
-
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
--
D
M
P
E
N
PVQAK
IS
IMN
W
MQ
A
ADD
A
SK
V
T
P
-Q-----
DG
L
K
---------
G
V
DKL
D
SN
I
R
LL
F
SL
A
G
N
YLANQ
N
P
D
VH
QAAK
-----------------------
L
L
E
D
ES
K
I
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETWG
T
A
SYLILSE
K
PIEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
L
G
-
-VEAEF
SQ
GR
D
E
KQ
W
I
E
H
I
W
--
E
QTR
L
AM
P
DEN
--------------------------------------------------------
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
FDM--
----
-QDPEIP
A
LSHYVPA
FE
GPEDKLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YA
-
N
-PW
L
QE
----
V
Q
T
Q
K
L
-
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VA
M
QA
GAW
WQ
P
D--AQGIDRG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|550676.3.peg.1721
Escherichia coli B185 (14-792/793)
QV
SRR
S
F
LQ
A
T
---
--
-
-
-
SALIT
LPF
ISSTAKAQS
P
DASPE
V
TAPVA
D
K
VVPTCSTFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
--------
TQITTLP
DN
E
LD
P
QM
-
-
-
PI
M
R
A
C
VR
G
RGYRK
F
V
YH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVH
V
GT
A
VS
G
GTFS-----GDA
M
AR
RL
L
N
LT
GG
YLE
----
YY
H
S
V
S
L
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
G
H
T
N
-----
YFFQKM
K
Q
-
N
G
TR
F
-
I
V
V
DP
R
Y
SD
T
VSSLA
D
Q
--
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
----------
DE
N
SMPEG
V
PANES
LV
A
Y
LF
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LA
R
D
YAT
T
K
P
-
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
--
D
M
P
E
N
PVQAK
IS
IMN
W
MQ
A
ADD
A
SK
V
T
P
-Q-----
DG
L
K
---------
G
V
DKL
D
SN
I
R
LL
F
SL
A
G
N
YLANQ
N
P
D
VH
QAAK
-----------------------
L
L
E
D
ES
K
I
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETWG
T
A
SYLILSE
K
LIEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
L
G
-
-VEAEF
SQ
GR
D
E
KQ
W
I
E
H
I
W
--
E
QTR
L
AM
P
DEN
--------------------------------------------------------
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
FDM--
----
-QDPEIP
A
LSHYVPA
FE
GPEDKLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YA
-
N
-PW
L
QE
----
V
Q
T
Q
K
L
-
W
L
NP
Q
DA
KQ
RGI
VE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VA
M
QA
GAW
WQ
P
D--AQGIDRG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|562.372.peg.1935
Escherichia coli 1212A (14-792/793)
QV
SRR
S
F
LQ
A
T
---
--
-
-
-
SALIT
LPF
ISSTAKAQS
P
DASPE
V
TAPVA
D
K
VVPTCSTFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
--------
TQITTLP
DN
E
LD
P
QM
-
-
-
PI
M
R
A
C
VR
G
RGYRK
F
V
YH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVH
V
GT
A
VS
G
GTFS-----GDA
M
AR
RL
L
N
LT
GG
YLE
----
YY
H
S
V
S
L
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
G
H
T
N
-----
YYFQKM
K
Q
-
N
G
TR
F
-
I
V
V
DP
R
Y
SD
T
VSSLA
D
Q
--
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
----------
DE
N
SMPEG
V
PANES
LV
A
Y
LF
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LA
R
D
YAT
T
K
P
-
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
--
D
M
P
E
N
PVQAK
IS
IMN
W
MQ
A
ADD
A
SK
V
T
P
-Q-----
DG
L
K
---------
G
V
DKL
D
SN
I
R
LL
F
SL
A
G
N
YLANQ
N
P
D
VH
QAAK
-----------------------
L
L
E
D
ES
K
I
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETWG
T
A
SYLILSE
K
PIEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
L
G
-
-VEAEF
SQ
GR
D
E
KQ
W
I
E
H
I
W
--
E
QTR
L
AM
P
DEN
--------------------------------------------------------
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
FDM--
----
-QDPEIP
A
LSHYVPA
FE
GPEDKLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YA
-
N
-PW
L
QE
----
V
Q
T
Q
K
L
-
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
I
P
R
II
PGV
VA
M
QA
GAW
WQ
P
D--AQGIDRG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|562.374.peg.3138
Escherichia coli 536A (14-792/793)
QV
SRR
S
F
LQ
A
T
---
--
-
-
-
SALIT
LPF
ISSTAKAQS
P
DASPE
V
TAPVA
D
K
VVPTCSTFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
--------
TQITTLP
DN
E
LD
P
QM
-
-
-
PI
M
R
A
C
VR
G
RGYRK
F
V
YH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVH
V
GT
A
VS
G
GTFS-----GDA
M
AR
RL
L
N
LT
GG
YLE
----
YY
H
S
V
S
L
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
G
H
T
N
-----
YYFQKM
K
Q
-
N
G
TR
F
-
I
V
V
DP
R
Y
SD
T
VSSLA
D
Q
--
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
----------
DE
N
SMPEG
V
PANES
LV
A
Y
LF
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LA
R
D
YAT
T
K
P
-
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
--
D
M
P
E
N
PVQAK
IS
IMN
W
MQ
A
ADD
A
SK
V
T
P
-Q-----
DG
L
K
---------
G
V
DKL
D
SN
I
R
LL
F
SL
A
G
N
YLANQ
N
P
D
VH
QAAK
-----------------------
L
L
E
D
ES
K
I
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETWG
T
A
SYLILSE
K
PIEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
L
G
-
-VEAEF
SQ
GR
D
E
KQ
W
I
E
H
I
W
--
E
QTR
L
AM
P
DEN
--------------------------------------------------------
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
FDM--
----
-QDPEIP
A
LSHYVPA
FE
GPEDKLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YA
-
N
-PW
L
QE
----
V
Q
T
Q
K
L
-
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
I
P
R
II
PGV
VA
M
QA
GAW
WQ
P
D--AQGIDRG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|155864.8.peg.3293
Escherichia coli O157:H7 EDL933 (14-792/793)
QV
SRR
S
F
LQ
A
T
---
--
-
-
-
SALIT
LPF
ISSTAKAQS
P
DASPE
V
TAPVA
D
K
VVPTCSTFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
--------
TQITTLP
DN
E
LD
P
QM
-
-
-
PI
M
R
A
C
VR
G
RGYRK
F
V
YH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVH
V
GT
A
VX
G
GTFS-----GDA
M
AR
RL
L
N
LT
GG
YLE
----
YY
H
S
V
S
L
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
G
H
T
N
-----
YYFQKM
K
Q
-
N
G
TR
F
-
I
V
V
DP
R
Y
SD
T
VSSLA
D
Q
--
WI
XLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
----------
DE
N
SMPEG
V
PANES
LV
A
Y
LF
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LA
R
D
YAT
T
K
P
-
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
--
D
M
P
E
N
PVQAK
IS
IMN
W
MQ
A
ADD
A
SK
V
T
P
-Q-----
DG
L
K
---------
G
V
DKL
D
SN
I
R
LL
F
SL
A
G
N
YLANQ
N
P
D
VH
QAAK
-----------------------
L
L
E
D
ES
K
I
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETWG
T
A
SYLILSE
K
PIEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
L
G
-
-VEAEF
SQ
GR
D
E
KQ
W
I
E
H
I
W
--
E
QTR
L
AM
P
DEN
--------------------------------------------------------
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
FDM--
----
-QDPEIP
A
LSHYVPA
FE
GPEDKLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YA
-
N
-PW
L
QE
----
V
Q
T
Q
K
L
-
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VA
M
QA
GAW
WQ
P
D--AQGIDRG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|701177.3.peg.3080
Escherichia coli O55:H7 str. CB9615 (14-792/793)
QV
SRR
S
F
LQ
A
T
---
--
-
-
-
SALIT
LPF
ISSTAKAQS
P
DASPE
V
TAPVA
D
K
VVPTCSTFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
--------
TQITTLP
DN
E
LD
P
QM
-
-
-
PI
M
R
A
C
VR
G
RGYRK
F
V
YH
P
----
DRL
KY
PM
K
R
V
G
K
---
RGEG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVH
V
GT
A
VS
G
GTFS-----GDA
M
AR
RL
L
N
LT
GG
YLE
----
YY
H
S
V
S
L
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
G
H
T
N
-----
YYFQKM
K
Q
-
N
G
TR
F
-
I
V
V
DP
R
Y
SD
T
VSSLA
D
Q
--
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
----------
DE
N
SMPEG
V
PANES
LV
A
Y
LF
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LA
R
D
YAT
T
K
P
-
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
--
D
M
P
E
N
PVQAK
IS
IMN
W
MQ
A
ADD
A
SK
V
T
P
-Q-----
D
R
L
K
---------
G
V
DKL
D
SN
I
R
LL
F
SL
A
G
N
YLANQ
N
P
D
VH
QAAK
-----------------------
L
L
E
D
ES
K
I
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETWG
T
A
SYLILSE
K
LIEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
L
G
-
-VEAEF
SQ
GR
D
E
KQ
W
I
E
H
I
W
--
E
QTR
L
AM
P
DEN
--------------------------------------------------------
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
FDM--
----
-QDPEIP
A
LSHYVPA
FE
GPEDKLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YA
-
N
-PW
L
QE
----
V
Q
T
Q
K
L
-
W
L
NP
Q
DA
KQ
S
GI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VA
M
QA
GAW
WQ
P
D--AQGIDRG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|1040638.4.peg.3965
Escherichia coli O104:H4 str. LB226692 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
V
EQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
TE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|6666666.5357.peg.325
Escherichia coli TY-2482 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
V
EQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
TE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|585055.6.peg.2081
Escherichia coli 55989 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
V
EQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
TE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|585055.8.peg.2084
Escherichia coli 55989 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
V
EQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
TE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|656444.3.peg.2806
Escherichia coli TA280 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
S
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
VVAAQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEGR
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GSADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|595495.4.peg.3778
Escherichia coli KO11 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTT
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
T
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
I
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LR
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
M
R
A
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
H
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|566546.3.peg.4106
Escherichia coli W (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTT
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
T
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
I
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LR
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
M
R
A
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
H
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|566546.4.peg.2039
Escherichia coli W (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTT
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
T
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
I
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LR
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
M
R
A
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
H
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|550676.3.peg.2194
Escherichia coli B185 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|701177.3.peg.2329
Escherichia coli O55:H7 str. CB9615 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAQ
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|656443.3.peg.2562
Escherichia coli TA271 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
S
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKIGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|656419.3.peg.2603
Escherichia coli M718 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
Q
S
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
N
V
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|340184.3.peg.3183
Escherichia coli B7A (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IV
A
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
Y
A
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|340184.6.peg.3322
Escherichia coli B7A (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IV
A
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
Y
A
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|216592.1.peg.1434
Escherichia coli 042 (9-797/815)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
F
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAAQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|216592.3.peg.2121
Escherichia coli 042 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
F
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAAQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|656379.3.peg.2358
Escherichia coli FVEC1302 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEI
S
GVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAAQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|656380.3.peg.3321
Escherichia coli FVEC1412 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEI
S
GVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAAQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|749549.3.peg.3150
Escherichia coli MS 198-1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEI
S
GVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAAQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|585056.7.peg.2355
Escherichia coli UMN026 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEI
S
GVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAAQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|585397.7.peg.2169
Escherichia coli ED1a (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
V
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IDFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
VQ
G
KH
D
K
A
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYA
A
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|585397.9.peg.2165
Escherichia coli ED1a (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
V
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IDFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
VQ
G
KH
D
K
A
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYA
A
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|331111.12.peg.2381
Escherichia coli E24377A (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
S
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IDFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
ITVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
VFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|331111.3.peg.4520
Escherichia coli E24377A (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
S
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IDFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
ITVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
VFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|340186.3.peg.3088
Escherichia coli E110019 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTT
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
T
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|340186.5.peg.3218
Escherichia coli E110019 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTT
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
T
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|550677.3.peg.1363
Escherichia coli B354 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAT
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GSADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
K
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|409438.11.peg.2261
Escherichia coli SE11 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTT
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
T
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRSSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAG
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
TR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|585057.4.peg.1235
Escherichia coli IAI39 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
A
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
N
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
E
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GSADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|585057.6.peg.1234
Escherichia coli IAI39 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
A
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
N
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
E
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GSADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|670888.3.peg.391
Escherichia coli 1827-70 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|481805.3.peg.1897
Escherichia coli ATCC 8739 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|481805.6.peg.1891
Escherichia coli ATCC 8739 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|413997.3.peg.1930
Escherichia coli B str. REL606 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|469008.4.peg.1820
Escherichia coli BL21(DE3) (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|331112.3.peg.1852
Escherichia coli HS (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|331112.6.peg.1927
Escherichia coli HS (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|679206.4.peg.2130
Escherichia coli MS 119-7 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|749537.3.peg.1303
Escherichia coli MS 115-1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTT
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
T
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IDFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LR
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
M
R
A
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|562.371.peg.4749
Escherichia coli 1044A (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
Y
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAQ
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|562.372.peg.4979
Escherichia coli 1212A (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
Y
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAQ
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|562.374.peg.4131
Escherichia coli 536A (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
Y
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAQ
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|656393.3.peg.2679
Escherichia coli H299 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
C
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GSADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|83334.1.peg.2609
Escherichia coli O157:H7 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
Y
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAQ
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|155864.1.peg.2617
Escherichia coli O157:H7 EDL933 (9-797/815)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
Y
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAQ
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|155864.8.peg.2480
Escherichia coli O157:H7 EDL933 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
Y
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAQ
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|444454.5.peg.1343
Escherichia coli O157:H7 str. EC4024 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
Y
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAQ
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|444449.5.peg.843
Escherichia coli O157:H7 str. EC4042 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
Y
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAQ
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|444448.5.peg.5131
Escherichia coli O157:H7 str. EC4045 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
Y
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAQ
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|444453.5.peg.4463
Escherichia coli O157:H7 str. EC4076 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
Y
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAQ
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|444452.5.peg.1019
Escherichia coli O157:H7 str. EC4113 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
Y
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAQ
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|444450.8.peg.2642
Escherichia coli O157:H7 str. EC4115 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
Y
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAQ
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|444451.5.peg.4077
Escherichia coli O157:H7 str. EC4196 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
Y
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAQ
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|444447.5.peg.4856
Escherichia coli O157:H7 str. EC4206 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
Y
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAQ
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|478004.5.peg.4518
Escherichia coli O157:H7 str. EC4401 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
Y
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAQ
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|478006.5.peg.2783
Escherichia coli O157:H7 str. EC4501 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
Y
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAQ
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|478007.5.peg.4494
Escherichia coli O157:H7 str. EC508 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
Y
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAQ
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|478008.5.peg.4786
Escherichia coli O157:H7 str. EC869 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
Y
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAQ
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|637388.3.peg.4708
Escherichia coli O157:H7 str. FRIK2000 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
Y
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAQ
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|570506.3.peg.4096
Escherichia coli O157:H7 str. FRIK966 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
Y
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAQ
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|386585.9.peg.2707
Escherichia coli O157:H7 str. Sakai (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
Y
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAQ
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|544404.4.peg.2505
Escherichia coli O157:H7 str. TW14359 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
Y
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAQ
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|502346.5.peg.4803
Escherichia coli O157:H7 str. TW14588 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
Y
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAQ
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|344601.3.peg.3663
Escherichia coli B171 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|344601.5.peg.3822
Escherichia coli B171 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|340185.3.peg.3839
Escherichia coli E22 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|340185.4.peg.4050
Escherichia coli E22 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|749533.3.peg.2495
Escherichia coli MS 84-1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|585395.4.peg.2235
Escherichia coli O103:H2 str. 12009 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|573235.3.peg.2764
Escherichia coli O26:H11 str. 11368 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|679204.3.peg.3144
Escherichia coli MS 145-7 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
Y
A
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|656408.3.peg.2047
Escherichia coli H591 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
S
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|749547.3.peg.1206
Escherichia coli MS 187-1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
LF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|585034.4.peg.1936
Escherichia coli IAI1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
VFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|585034.5.peg.1931
Escherichia coli IAI1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
VFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|585396.4.peg.2548
Escherichia coli O111:H- str. 11128 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMLHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|595496.3.peg.1842
Escherichia coli BW2952 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFD
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AV
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGH
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRHSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYA
I
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|536056.3.peg.1870
Escherichia coli DH1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFD
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AV
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGH
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRHSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYA
I
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|83333.1.peg.1856
Escherichia coli K12 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFD
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AV
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGH
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRHSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYA
I
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|316407.3.peg.1828
Escherichia coli W3110 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFD
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AV
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGH
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRHSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYA
I
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|316385.7.peg.2040
Escherichia coli str. K-12 substr. DH10B (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFD
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AV
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGH
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRHSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYA
I
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|511145.12.peg.1952
Escherichia coli str. K-12 substr. MG1655 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFD
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AV
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGH
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRHSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYA
I
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|511145.6.peg.1936
Escherichia coli str. K-12 substr. MG1655 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFD
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AV
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGH
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRHSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYA
I
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|749538.3.peg.4492
Escherichia coli MS 116-1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFD
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AV
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGH
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYA
I
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|749544.3.peg.2393
Escherichia coli MS 175-1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFD
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AV
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGH
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYA
I
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|679207.4.peg.4773
Escherichia coli MS 107-1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTT
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
T
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IDFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LR
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
M
R
A
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
VFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAG
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|439855.10.peg.1471
Escherichia coli SMS-3-5 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
I
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
VQ
G
KH
D
K
A
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LI
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ESGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|749545.3.peg.2995
Escherichia coli MS 182-1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RG
K
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
M
R
A
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLVPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAG
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|749532.3.peg.2439
Escherichia coli MS 78-1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RG
K
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
M
R
A
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLVPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAG
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|749548.3.peg.4800
Escherichia coli MS 196-1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFD
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AV
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGH
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKS
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYA
I
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
VN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|358709.5.peg.3773
Escherichia coli 101-1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
YEQHDRIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
VVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|431946.3.peg.1798
Escherichia coli SE15 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDHIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
D
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
N
D
NTP
K
S
AA
WAAEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
I
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
RT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
-L
-
N
YAE
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|562.373.peg.5648
Escherichia coli 1125A (3-791/809)
L
T
RR
E
F
I
K
H
S
G
I
A
AG
A
L
-
-----
---
---VVTSAA
P
-----
L
PAWAE
EK
---GGKILT
A
G
RW
G
A
M
N
V
E
V
K
D
GK
IVSSTGALA
KTIPNSL
Q
S
T
AA
D
QV
-
-
-
----
-
-
--
-
-HTTA
R
I
QH
P
MVRKSY
L
DN
P
L
Q
P
A
K
G
---
RGE
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F--
-
-A
G
SY
G
WRSSGVLHKAQT
L
LQ
R
Y
MN
LA
GG
YSG
----
HS
G
D
YS
T
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WS
S
T
DEQGL
EYFHQL
K
K
-
S
G
KP
V
-
I
A
IDP
I
R
SE
T
IEFFG
Y
NAT
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
----------
PQ
-
-----
-
-----
FE
E
Y
LT
G
-
K
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
Q
I
V
KLA
-
E
LMA
A
N
R
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
--
E
M
-
S
A
AIAGQ
A
S
---
-
-E
A
ADD
G
G-
MTA
IPVARIV
D
AL
E
NPGGKYQHN
GK
EQT
Y
PN
IK
MI
W
-W
A
G
G
GNFTH
H
Q
D
T
N
RLIK
-----------------------
A
W
Q
-
--
K
P
E
M
IVV
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
LTMTGDYS
N
Q
-HIVPMK
Q
AVAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGKEIY
TEG
K
D
E
MA
W
L
K
F
F
Y
DA
A
QKG
A
RA
Q
RVT
--------------------------------------------------------
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
EKFGY
----
-KDCPAH
P
TWLAPDE
W
K
GTADEKQ----
L
----
QL
L
T
A
H
PAH
C
L
HS
Q
-
-L
-
N
YAQ
L
RK
KYAV
A
D
R
E
P
I
-
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VC
V
HE
GAW
--
P
DL-ENGLCKN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|409438.11.peg.4899
Escherichia coli SE11 (3-757/758)
ISRR
S
F
LQ
G
M
G
IG
CS
A
C
A
LGVFS
P
--
---GTLARN
P
-----
V
AGIKG
K
T
TLTPTLCEM
C
S
FR
C
P
V
Q
A
Q
V
V
N
NK
T
--------
VFIQG--
N
P
S
AS
H
QG
-
-
-
--
T
R
V
C
AR
G
GSGVS
L
V
ND
P
----
Q
R
I
VK
PM
K
R
T
G
P
---
RG
S
G
E
W
QV
ISW
Q
Q
A
Y
Q
E
I
AAKMNAIK
A
QY
G
P
E
SV
VFS
S
KA
G
--
-
-----------S
L
SS
H
L
F
H
LA
TA
FGS
P
N
TF
TH
A
S
T
C
P
A
G
K
AIAAKVMM
G
G--------
D
LAMD
I
A
N
T
RY
L
V
S
FG
H
N
L
Y
E
G
IE
V
A
DT
-
-
-----
HELMAA
Q
E
-
K
G
AR
M
-
V
S
F
DP
R
L
S-
I
FSSKA
DE
--
W
H
AIR
PG
G
D
L
A
V
LLA
M
C
HV
M
I
DE
Q
LY
D
A
D
F
V
E
R
Y
T
--------
T
G
F
----------
EQ
L
ALA--
-
-----
--
-
-
--
--
V
K
D
A--
-
T
PE
WAA
TQAD
VP
AD
V
I
V
RV
T
R
E
LAA
C
A
P
H
AI
V
SP
G
-
--
-
-
H
R
S
TF
S
Q
EE
IDM
RRM
I
FT
L
NA
L
L
G
N
I
E
RK
G
-
G
LYQ
KK
G
AAVYNKLAGE-----KVA
P
--
T
L
-
-
-
---AK
I
D
---
-
--
-
VKN
M
PK
P
TA
QRIDLVA
PQF
R
---------
--
---
-
--
--
--
Y
IA
A
G
G
GVVQS
I
I
D
AA
LTRK
P
YPIKAWIMSRHNPFQTVTCRPD
L
VK
T
VE
R
L
D
L
V
V
SC
D
V
Y
L
S
E
SA
A
Y
AD
Y
LLP
EC
T
YL
E
R
D
E
DVTDMSGL
H
P
AYGL-RQ
Q
VVEPV
G
E
A
R
P
S
WQIWK
E
L
G
QQ
L
G
L
GQYYPW
Q
D
M
Q
T
R
Q-
-
-
-
-
L
Y
QLN
GDH
A
LA
A
RLR
--------------------------------------------------------
EK
G
Y
L
EWGVP
-
-
LL
-LREAESV
Q
QF
T
A
RYP
NA
LA
A
D
S
DN
TY
GE
QL
R
F
-
K
S
PSGKIE
L
C
S
EV
L
EGL--
----
-------
-
-------
LP
GYGVPRSRDFT
L
KRDD
E
L
Y
F
I
Q
GKV
A
V
H
T
N
G
AT
-
Q
YVP
L
LS
--
ELM
W
DN
A
V
-
W
I
H
P
Q
T
A
RE
K
GI
KT
GD
E
I
W
L
E
N
A
T
G
K
E
KGK
A
L
VT
P
G
IR
P
DT
LF
V
YM
G
F
G
AR
A
GAKTAATTHG
I
HC
G
N
L
L
PHV
T
SP
-
-VS
GTVVHTA
G
V
T
L
S
R
fig|331111.12.peg.2791
Escherichia coli E24377A (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SDT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSK
Y
PVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|331111.3.peg.246
Escherichia coli E24377A (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SDT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSK
Y
PVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|405955.13.peg.2427
Escherichia coli APEC O1 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|405955.9.peg.1980
Escherichia coli APEC O1 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|585397.7.peg.2674
Escherichia coli ED1a (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLY
D
VLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|585397.9.peg.2671
Escherichia coli ED1a (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLY
D
VLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|714962.3.peg.2487
Escherichia coli IHE3034 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|585035.6.peg.2333
Escherichia coli S88 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|869729.3.peg.1224
Escherichia coli UM146 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|364106.7.peg.2513
Escherichia coli UTI89 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|364106.8.peg.2514
Escherichia coli UTI89 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|656393.3.peg.3239
Escherichia coli H299 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSK
Y
PVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|656408.3.peg.2457
Escherichia coli H591 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSK
Y
PVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|679206.4.peg.2433
Escherichia coli MS 119-7 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSK
Y
PVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|585396.4.peg.3038
Escherichia coli O111:H- str. 11128 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSK
Y
PVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|573235.3.peg.3207
Escherichia coli O26:H11 str. 11368 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSK
Y
PVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|656443.3.peg.2917
Escherichia coli TA271 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSK
Y
PVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|656444.3.peg.3201
Escherichia coli TA280 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
W
EQ
A
F
D
V
M
EDKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
D
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSK
Y
PVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|585057.4.peg.2440
Escherichia coli IAI39 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
K
M
GEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|585057.6.peg.2443
Escherichia coli IAI39 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
K
M
GEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|753642.3.peg.2881
Escherichia coli NC101 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFP
L
SELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|562.376.peg.4130
Escherichia coli WV_060327 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|413997.3.peg.2229
Escherichia coli B str. REL606 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
T
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|511693.5.peg.2241
Escherichia coli BL21 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
T
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|469008.4.peg.1494
Escherichia coli BL21(DE3) (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
T
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|656417.3.peg.2882
Escherichia coli M605 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAYRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|155864.1.peg.3094
Escherichia coli O157:H7 EDL933 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VXGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|155864.8.peg.2988
Escherichia coli O157:H7 EDL933 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VXGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|362663.8.peg.2267
Escherichia coli 536 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFP
L
SELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|362663.9.peg.2271
Escherichia coli 536 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFP
L
SELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|340197.3.peg.268
Escherichia coli F11 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFP
L
SELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|340197.5.peg.278
Escherichia coli F11 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFP
L
SELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|685038.3.peg.2268
Escherichia coli O83:H1 str. NRG 857C (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFP
L
SELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|439855.10.peg.2521
Escherichia coli SMS-3-5 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFP
L
SELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|216592.1.peg.3014
Escherichia coli 042 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|216592.3.peg.2559
Escherichia coli 042 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|358709.5.peg.658
Escherichia coli 101-1 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|670888.3.peg.4074
Escherichia coli 1827-70 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|344610.3.peg.1688
Escherichia coli 53638 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|344610.7.peg.4193
Escherichia coli 53638 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|525281.3.peg.4014
Escherichia coli 83972 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|655817.3.peg.2656
Escherichia coli ABU 83972 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|481805.3.peg.1547
Escherichia coli ATCC 8739 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|481805.6.peg.1539
Escherichia coli ATCC 8739 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|550672.3.peg.1927
Escherichia coli B088 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|550677.3.peg.1754
Escherichia coli B354 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|340184.3.peg.400
Escherichia coli B7A (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|340184.6.peg.417
Escherichia coli B7A (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|199310.1.peg.2674
Escherichia coli CFT073 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|199310.4.peg.2585
Escherichia coli CFT073 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|340186.3.peg.1313
Escherichia coli E110019 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
G
Q
YDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAE
E
QLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|340186.5.peg.1362
Escherichia coli E110019 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
G
Q
YDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAE
E
QLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|340185.3.peg.640
Escherichia coli E22 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|340185.4.peg.683
Escherichia coli E22 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|656379.3.peg.2742
Escherichia coli FVEC1302 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|656380.3.peg.2301
Escherichia coli FVEC1412 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|331112.3.peg.2200
Escherichia coli HS (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|331112.6.peg.2300
Escherichia coli HS (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|679205.4.peg.5334
Escherichia coli MS 124-1 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|679204.3.peg.243
Escherichia coli MS 145-7 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|749546.3.peg.2990
Escherichia coli MS 185-1 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|585395.4.peg.2807
Escherichia coli O103:H2 str. 12009 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|409438.11.peg.2632
Escherichia coli SE11 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|431946.3.peg.2180
Escherichia coli SE15 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|656440.3.peg.2193
Escherichia coli TA206 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLY
D
VLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|585056.7.peg.2724
Escherichia coli UMN026 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|1040638.4.peg.3289
Escherichia coli O104:H4 str. LB226692 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
GGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|6666666.5357.peg.553
Escherichia coli TY-2482 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
GGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|585055.6.peg.2495
Escherichia coli 55989 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
GGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|585055.8.peg.2501
Escherichia coli 55989 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
GGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|562.375.peg.3193
Escherichia coli EC4100B (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
GGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|585034.4.peg.2258
Escherichia coli IAI1 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
GGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|585034.5.peg.2255
Escherichia coli IAI1 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
GGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|595495.4.peg.227
Escherichia coli KO11 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
GGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|566546.3.peg.1426
Escherichia coli W (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
GGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|566546.4.peg.2388
Escherichia coli W (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
GGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|701177.3.peg.2772
Escherichia coli O55:H7 str. CB9615 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
QV
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|670897.3.peg.3185
Escherichia coli 2362-75 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFP
L
SELAEDQLNDES
H
ELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|216593.1.peg.2536
Escherichia coli E2348/69 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFP
L
SELAEDQLNDES
H
ELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|574521.7.peg.2407
Escherichia coli O127:H6 str. E2348/69 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFP
L
SELAEDQLNDES
H
ELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|656437.3.peg.2479
Escherichia coli TA143 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
KP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
DV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFP
L
SELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|595496.3.peg.2177
Escherichia coli BW2952 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
D
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|536056.3.peg.1525
Escherichia coli DH1 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
D
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|656414.3.peg.2581
Escherichia coli H736 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
D
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|83333.1.peg.2180
Escherichia coli K12 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
D
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|316407.3.peg.2138
Escherichia coli W3110 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
D
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|316385.5.peg.2331
Escherichia coli str. K-12 substr. DH10B (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
D
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|316385.7.peg.2385
Escherichia coli str. K-12 substr. DH10B (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
D
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|511145.12.peg.2295
Escherichia coli str. K-12 substr. MG1655 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
D
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|511145.6.peg.2279
Escherichia coli str. K-12 substr. MG1655 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
D
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|562.371.peg.5067
Escherichia coli 1044A (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|562.373.peg.3956
Escherichia coli 1125A (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|562.372.peg.5562
Escherichia coli 1212A (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|562.374.peg.3356
Escherichia coli 536A (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|550676.3.peg.2527
Escherichia coli B185 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|656419.3.peg.2966
Escherichia coli M718 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|83334.1.peg.3089
Escherichia coli O157:H7 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|444454.5.peg.2021
Escherichia coli O157:H7 str. EC4024 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|444448.5.peg.244
Escherichia coli O157:H7 str. EC4045 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|444453.5.peg.1590
Escherichia coli O157:H7 str. EC4076 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|444452.5.peg.2609
Escherichia coli O157:H7 str. EC4113 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|444450.8.peg.3334
Escherichia coli O157:H7 str. EC4115 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|444451.5.peg.792
Escherichia coli O157:H7 str. EC4196 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|444447.5.peg.378
Escherichia coli O157:H7 str. EC4206 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|478004.5.peg.1754
Escherichia coli O157:H7 str. EC4401 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|478005.5.peg.1871
Escherichia coli O157:H7 str. EC4486 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|478006.5.peg.4988
Escherichia coli O157:H7 str. EC4501 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|478007.5.peg.4994
Escherichia coli O157:H7 str. EC508 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|478008.5.peg.2367
Escherichia coli O157:H7 str. EC869 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|637388.3.peg.376
Escherichia coli O157:H7 str. FRIK2000 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|570506.3.peg.4956
Escherichia coli O157:H7 str. FRIK966 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|386585.9.peg.3229
Escherichia coli O157:H7 str. Sakai (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|544404.4.peg.3137
Escherichia coli O157:H7 str. TW14359 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|502346.5.peg.4285
Escherichia coli O157:H7 str. TW14588 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QD
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|344601.3.peg.1443
Escherichia coli B171 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNDK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|344601.5.peg.1519
Escherichia coli B171 (2-828/828)
K
L
SRR
S
F
MK
A
N
A
V
A
AA
A
A
A
AGL--
---
-------SV
P
GVARA
V
VGQQE
AI
KWDKAPCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
--------
VACQGDP
D
A
P
VN
R
GL
-
-
-
----
N
C
IK
G
YFLPK
I
M
YG
K
----
DRL
TQ
P
L
L
R
M
K
N
GKYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
---
-
--
G
MF
G
SGQWTIWEGYAA
-
-S
K
L
FK
--
A
G
FRS
NNID
PN
A
R
HC
M
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
R
I
-----
----TN
R
R
L
SN
QN
VTV
A
VLS
T
Y
QH
R
SFELA
D
N
--
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEK
AA
K
NPGSD
A
SEPMS
FE
D
Y
--
--
K
A
F
VAE
Y
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y--
A
D
P
N
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
AD
M
V
V
T
N
EKHRD
I
C
EKK
W
NI
P
SGT
I
PA
KIG
LHAVAQD
RAL
K
---------
--
---
D
GK
LN
VY
W
TM
C
T
N
NM-QA
G
P
N
IN
EERM
P
----------------------
G
WR
D
PR
-
-
N
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
G
AYGNAERR
TQ
----FWR
Q
QVQAP
G
E
A
K
S
D
LWQLV
Q
F
S
R
R
F
-
-
------
---
K
T
E
EV
W
P
E
E
L
L
--
-
---
A
KK
P
ELR
GKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHD
L
A
P
F
D
DYHKA
-
R
G
L
RWPVVNDK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
-
-----
----
-------
-
-------
FE
PAAEAPDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
S
MT
RR
VPE
L
HR
----
A
F
PE
A
V
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
PQ
GL
V
YM
PFF
DA
A
QL--------
-
-V
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
Consen1
Primary consensus
mkAeisRR
lmK
taig
A
a
lpf
p
-----
v
ek
cG
c
l
l
v
d
v
--------
dnt
d
-
g
hqvr
c
g
rm
p
----
drL
Pm
r
g
---
rgEg
f
isWdeA
d
i
k
Gneai
y
G
G
-
rlmn
gG
----
g
ys
a
i
G
d
----
iens
vVlfG
Np
et
s
gg
t
-----
re
Sn
m
-
i
idp
y
t
De
--
wi
pgtD
al
iA
li
n
dq
Fl
Ky
--------
GY
----------
k
a
yk
Y
geg
d
kt
waaeiTgvP
ki
kLA
e
a
p
-
i
gW
--
G
qrh
Ge
---
i
L
ltG
vg
G
-
G
---
G
P
--
l
-
n
is
w
a
g
mta
dgvr
---------
gk
d
ik
W
a
n
h
diN
-----------------------
lqd
k
e
Ivvid
f
T
sAk
aDilLP
m
Eq
d
nm
q
fE
k
i
e
akrl
p
tegr
q
W
k
l
--
a
a
p
--------------------------------------------------------
lp
fe
-
gi
e
vay
--
fr
DP
n
-----
l
-
tPsGKieIys
l
twel
p
fe
L
----
qL
g
h
r
Hs
-
-
n
L
----
A
rq
v
-
Inp
DA
rgi
GD
Vrv
n
rGev
a
vt
r
pgv
v
gaw
a
g
N
LT
psp
-
Lak
lV
iEKv
Consen2
Secondary consensus
la
k
t
f
g
a
-
---
agvara
ai
a
g
t
q
ivsstgala
q
p
r
d
-
----
-
-
i
kmvrksy
l
p
k
gkydk
d
y
vt
eq
k
m
e
pssv
-
l
kyfk
a
nnid
a
hc
g
a
swplilaq
f
mw
m
nm
i
ws
ideqgl
k
g
vtv
vls
r
r
natgl
mqs
vi
l
m
g
nk
f
h
nlrkgatd
glrpthplek
-
-
fe
--
k
f
ys
kts
m
si
l
q
l
t
rn
y
tm
nqq
v
ml
is
c
pfs
ad
v
a
ac
-
p
i
kig
ral
npggkyqhn
--
y
ln
c
g
g
t
p
wr
-
-
n
igse
a
l
c
l
t
g
tq
p
g
r
d
s
lf
-
---
k
e
f
da
-
e
q
gktlyevlyatpevskfpvselaedqlndesrelgfylqkglfeeyawfgrghghdma
y
n
ll
g
wrf
eg
kagegy
fy
k
d
av
fa
-
----
-
w
w
t
r
h
t
s
rr
kyav
pe
l
ht
fdl
ki
s
n
q
v
tr
g
kpq
pff
p
-
tdsq
sn
a
i
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character