fig|562.375.peg.1686
Escherichia coli EC4100B
MSKN
D
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAT-
-
-
--
V-QQASE
K
VI
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
T
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|749532.3.peg.1355
Escherichia coli MS 78-1
MSKN
D
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAT-
-
-
--
V-QQASE
K
VI
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
T
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|409438.11.peg.1855
Escherichia coli SE11
MSKN
D
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAT-
-
-
--
V-QQASE
K
VI
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
T
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|585034.4.peg.1621
Escherichia coli IAI1
MSKN
D
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAT-
-
-
--
V-QQASE
K
VI
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
T
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
I
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|585034.5.peg.1616
Escherichia coli IAI1
MSKN
D
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAT-
-
-
--
V-QQASE
K
VI
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
T
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
I
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|550672.3.peg.2427
Escherichia coli B088
MSKN
D
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAT-
-
-
--
V-QQASE
K
VI
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
T
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|340186.3.peg.17
Escherichia coli E110019
MSKN
D
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAT-
-
-
--
V-QQASE
K
VI
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
T
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
I
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
L
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|340186.5.peg.18
Escherichia coli E110019
MSKN
D
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAT-
-
-
--
V-QQASE
K
VI
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
T
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
I
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
L
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|679205.4.peg.1617
Escherichia coli MS 124-1
MSKN
D
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAT-
-
-
--
V-QQASE
K
VI
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
T
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANISGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|749533.3.peg.4939
Escherichia coli MS 84-1
MSKN
D
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAT-
-
-
--
V-QQASE
K
VI
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
T
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANISGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|340184.3.peg.1015
Escherichia coli B7A
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQARE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|340184.6.peg.1050
Escherichia coli B7A
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQARE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|679204.3.peg.504
Escherichia coli MS 145-7
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQARE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|595495.4.peg.2853
Escherichia coli KO11
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQARE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
I
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|566546.3.peg.1066
Escherichia coli W
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQARE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
I
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|566546.4.peg.1739
Escherichia coli W
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQARE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
I
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|344601.3.peg.331
Escherichia coli B171
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQARE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|344601.5.peg.329
Escherichia coli B171
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQARE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|585395.4.peg.1810
Escherichia coli O103:H2 str. 12009
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQARE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|595496.3.peg.1547
Escherichia coli BW2952
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRNAAAA-
-
-
--
V-QQARE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|536056.3.peg.2167
Escherichia coli DH1
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRNAAAA-
-
-
--
V-QQARE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|656414.3.peg.1889
Escherichia coli H736
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRNAAAA-
-
-
--
V-QQARE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|83333.1.peg.1573
Escherichia coli K12
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRNAAAA-
-
-
--
V-QQARE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|749538.3.peg.4136
Escherichia coli MS 116-1
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRNAAAA-
-
-
--
V-QQARE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|749540.3.peg.4220
Escherichia coli MS 146-1
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRNAAAA-
-
-
--
V-QQARE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|749548.3.peg.4734
Escherichia coli MS 196-1
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRNAAAA-
-
-
--
V-QQARE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|316407.3.peg.1544
Escherichia coli W3110
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRNAAAA-
-
-
--
V-QQARE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|316385.5.peg.1699
Escherichia coli str. K-12 substr. DH10B
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRNAAAA-
-
-
--
V-QQARE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|316385.7.peg.1744
Escherichia coli str. K-12 substr. DH10B
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRNAAAA-
-
-
--
V-QQARE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|511145.12.peg.1658
Escherichia coli str. K-12 substr. MG1655
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRNAAAA-
-
-
--
V-QQARE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|511145.6.peg.1642
Escherichia coli str. K-12 substr. MG1655
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRNAAAA-
-
-
--
V-QQARE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|481805.3.peg.2201
Escherichia coli ATCC 8739
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRNAAAS-
-
-
--
V-QQARE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|481805.6.peg.2194
Escherichia coli ATCC 8739
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRNAAAS-
-
-
--
V-QQARE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|1040638.4.peg.3633
Escherichia coli O104:H4 str. LB226692
MSKN
D
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VI
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
T
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVS
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|585055.6.peg.1782
Escherichia coli 55989
MSKN
D
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VI
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
T
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVS
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|585055.8.peg.1786
Escherichia coli 55989
MSKN
D
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VI
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
T
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVS
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|6666666.5357.peg.2358
Escherichia coli TY-2482
MSKN
D
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VI
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
T
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVS
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDP
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|656408.3.peg.1726
Escherichia coli H591
MSKN
D
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VI
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
T
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|679206.4.peg.1318
Escherichia coli MS 119-7
MSKN
D
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VI
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
T
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|525281.3.peg.976
Escherichia coli 83972
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAEAA-
-
-
--
V-QQANE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|655817.3.peg.1868
Escherichia coli ABU 83972
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAEAA-
-
-
--
V-QQANE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|405955.13.peg.1670
Escherichia coli APEC O1
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAEAA-
-
-
--
V-QQANE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|405955.9.peg.1355
Escherichia coli APEC O1
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAEAA-
-
-
--
V-QQANE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|199310.1.peg.1915
Escherichia coli CFT073
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAEAA-
-
-
--
V-QQANE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|199310.4.peg.1846
Escherichia coli CFT073
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAEAA-
-
-
--
V-QQANE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|749546.3.peg.3879
Escherichia coli MS 185-1
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAEAA-
-
-
--
V-QQANE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|749528.3.peg.3857
Escherichia coli MS 45-1
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAEAA-
-
-
--
V-QQANE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|585035.6.peg.1625
Escherichia coli S88
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAEAA-
-
-
--
V-QQANE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|364106.7.peg.1817
Escherichia coli UTI89
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAEAA-
-
-
--
V-QQANE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|364106.8.peg.1820
Escherichia coli UTI89
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAEAA-
-
-
--
V-QQANE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|439855.10.peg.1773
Escherichia coli SMS-3-5
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSSAAA-
-
-
--
V-QQASE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GNDE
Y
-
G
N
Q
QVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
E
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
NR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|550676.3.peg.1891
Escherichia coli B185
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LHSAAAA-
-
-
--
V-QQARE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
AWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLEVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|670897.3.peg.2337
Escherichia coli 2362-75
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAEAA-
-
-
--
V-QQANE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PEHSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|216593.1.peg.355
Escherichia coli E2348/69
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAEAA-
-
-
--
V-QQANE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PEHSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|574521.7.peg.1708
Escherichia coli O127:H6 str. E2348/69
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAEAA-
-
-
--
V-QQANE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PEHSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|685038.3.peg.1602
Escherichia coli O83:H1 str. NRG 857C
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAEAA-
-
-
--
V-QQANE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKNLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNVDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|753642.3.peg.1576
Escherichia coli NC101
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
ADGFS
LPF
T--LRSAEAA-
-
-
--
V-QQANE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
K
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSAFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|331111.12.peg.2081
Escherichia coli E24377A
MSKN
D
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VI
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
T
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
I
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|331111.3.peg.4224
Escherichia coli E24377A
MSKN
D
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VI
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
T
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
NTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
I
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|316401.4.peg.1867
Escherichia coli ETEC H10407
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRNAAAA-
-
-
--
V-QQARE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPQNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDLN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|656440.3.peg.4366
Escherichia coli TA206
MSK
K
E
Q
Q
VGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQANE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GNDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
ED
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWVLS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSIFP
L
----
QL
F
G
F
H
YKS
R
A
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEKV
fig|550677.3.peg.2969
Escherichia coli B354
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPD
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|749531.3.peg.4805
Escherichia coli MS 69-1
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GNDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EE
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|656393.3.peg.2375
Escherichia coli H299
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|656437.3.peg.1798
Escherichia coli TA143
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GNDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|431946.3.peg.1505
Escherichia coli SE15
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDK
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|656379.3.peg.2055
Escherichia coli FVEC1302
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GNDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
EVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|656380.3.peg.3018
Escherichia coli FVEC1412
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GNDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
EVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|749549.3.peg.5227
Escherichia coli MS 198-1
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GNDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
EVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|585056.7.peg.2059
Escherichia coli UMN026
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GNDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
EVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|749527.3.peg.4301
Escherichia coli MS 21-1
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GNDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
G
N
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|656417.3.peg.2077
Escherichia coli M605
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDK
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
HVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|562.371.peg.4430
Escherichia coli 1044A
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
Q
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
AWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNI
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KS
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|562.372.peg.4662
Escherichia coli 1212A
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
Q
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
AWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNI
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KS
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|562.374.peg.4447
Escherichia coli 536A
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
Q
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
AWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNI
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KS
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|83334.1.peg.2322
Escherichia coli O157:H7
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
Q
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
AWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNI
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KS
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|155864.1.peg.2330
Escherichia coli O157:H7 EDL933
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
Q
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
AWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNI
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KS
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|155864.8.peg.2169
Escherichia coli O157:H7 EDL933
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
Q
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
AWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNI
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KS
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|444454.5.peg.5571
Escherichia coli O157:H7 str. EC4024
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
Q
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
AWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNI
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KS
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|444449.5.peg.517
Escherichia coli O157:H7 str. EC4042
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
Q
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
AWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNI
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KS
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|444448.5.peg.4825
Escherichia coli O157:H7 str. EC4045
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
Q
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
AWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNI
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KS
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|444453.5.peg.4690
Escherichia coli O157:H7 str. EC4076
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
Q
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
AWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNI
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KS
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|444452.5.peg.3536
Escherichia coli O157:H7 str. EC4113
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
Q
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
AWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNI
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KS
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|444450.8.peg.2337
Escherichia coli O157:H7 str. EC4115
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
Q
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
AWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNI
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KS
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|444451.5.peg.3357
Escherichia coli O157:H7 str. EC4196
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
Q
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
AWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNI
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KS
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|444447.5.peg.5164
Escherichia coli O157:H7 str. EC4206
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
Q
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
AWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNI
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KS
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|478004.5.peg.4148
Escherichia coli O157:H7 str. EC4401
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
Q
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
AWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNI
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KS
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|478006.5.peg.4087
Escherichia coli O157:H7 str. EC4501
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
Q
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
AWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNI
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KS
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|478007.5.peg.3501
Escherichia coli O157:H7 str. EC508
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
Q
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
AWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNI
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KS
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|478008.5.peg.4497
Escherichia coli O157:H7 str. EC869
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
Q
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
AWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNI
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KS
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|637388.3.peg.5057
Escherichia coli O157:H7 str. FRIK2000
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
Q
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
AWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNI
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KS
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|570506.3.peg.4176
Escherichia coli O157:H7 str. FRIK966
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
Q
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
AWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNI
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KS
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|386585.9.peg.2401
Escherichia coli O157:H7 str. Sakai
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
Q
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
AWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNI
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KS
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|544404.4.peg.2200
Escherichia coli O157:H7 str. TW14359
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
Q
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
AWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNI
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KS
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|502346.5.peg.5112
Escherichia coli O157:H7 str. TW14588
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
Q
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
AWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNI
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KS
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|331112.3.peg.1563
Escherichia coli HS
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
IWVET--
D
N
T
GNDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
T
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PK
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NF
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANISGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|331112.6.peg.1630
Escherichia coli HS
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
IWVET--
D
N
T
GNDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
T
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PK
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NF
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANISGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|413997.3.peg.1631
Escherichia coli B str. REL606
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
IWVET--
D
N
T
GNDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
D
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
T
CQ
GW
--
G
P
K
R
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|511693.5.peg.1656
Escherichia coli BL21
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
IWVET--
D
N
T
GNDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
D
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
T
CQ
GW
--
G
P
K
R
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|469008.4.peg.2118
Escherichia coli BL21(DE3)
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
IWVET--
D
N
T
GNDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
D
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
T
CQ
GW
--
G
P
K
R
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|670888.3.peg.74
Escherichia coli 1827-70
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
IWVET--
D
N
T
GNDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
KR
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
T
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PK
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|216592.1.peg.2169
Escherichia coli 042
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
Y
E
AYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VE
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
SS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|216592.3.peg.1805
Escherichia coli 042
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
Y
E
AYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VE
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
SS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|701177.3.peg.1978
Escherichia coli O55:H7 str. CB9615
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
Q
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
AWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KS
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
C
GI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|562.373.peg.5332
Escherichia coli 1125A
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
Q
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
AWVET--
D
N
T
GSDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNI
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KS
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
LDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|358709.5.peg.1102
Escherichia coli 101-1
MSKNE
R
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
C
L
H
V
K
D
NE
V
IWVET--
D
N
T
GNDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
D
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPKNGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
T
CQ
GW
--
G
P
K
R
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARESTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
WL
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SR
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWNS
-----------------
PERRTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDL
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
F
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|585057.4.peg.1537
Escherichia coli IAI39
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GNDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPINGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARELTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
R
L
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|585057.6.peg.1537
Escherichia coli IAI39
MSKNE
Q
MVGISRR
T
L
V
K
S
T
A
--
IG
SL
A
L
A
AGGFS
LPF
T--LRSAAAA-
-
-
--
V-QQASE
K
VV
----
W
G
-
A
CSVN
CG
SR
C
A
L
R
L
H
V
K
D
NE
V
TWVET--
D
N
T
GNDE
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
I
N
HP
DRL
NY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
ASSLKKTV
E
QY
GNEA
V
YIQYS
S
G
--------------
IV
G
GNM
T
RSSPSASA-VK
R
L
MN
CY
GG
SLNQY
G
S
YS
T
--
A
Q
I
SCAMPYTY
G
S-NDGNSTT
D
----
IENS
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
IT
Y
LL
E
-KA
R
EK
SN
A
-
KM
I
V
IDP
R
Y
TD
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
A
AL
VAG
IA
WV
LI
NE
N
LV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPADAPINGH
YKAYI
L
G
E
G
D
D
KTA
KT
PQ
WA
S
Q
ITG
I
P
VD
R
I
I
KLARE
I
G
TAK
P
AY
I
CQ
GW
--
G
P
QR
Q
AN
GE
LT
---
ARA
I
AM
L
PI
LTG
N
VG
IS
G
-
G
---
NS
G
-----ARELTYTITIERL
P
V
------------------
L
-
DNPVK
T
S
I
SCFSWTD
A
IDH
G
PQ
MTA
IR
-----
DG
V
---------
R
GK
DKLDVP
IK
FI
W
NY
A
G
N
TLV
-----------------------
N
Q
H
SDI
N
KTH
E
I
L
QDES
KC
-
E
M
IV
V
I
E
N
F
M
T
S
SAK
Y
ADILLP
DL
M
TV
EQ
E
D
IIPNDYA
GN
MG--YLIFL
Q
P
V
TSEK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
K
FTE
----------
GR
TQEQ
R
L
-------------------------------
Q
H
LY
--
A
KMLAKDPA--
LP
S
Y
D
ELKKM
-
-
GI
-YKRKDPN
G
HF
VAY
--
KA
FR
D
DP
EA
N
-----
P
L
-
K
TPSGKIEIYS
SK
LA
EI
A
R
TWEL
EKDEV
I
S
PLP
V
Y
AST
F
EGWDS
-----------------
PERSTFP
L
----
QL
F
G
F
H
YKS
R
T
HS
T
-
YGNIDV
L
KA----
A
CRQE
V
W
INP
I
DA
QK
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
A
K
VT
P
R
IL
PGV
SAMG
QGAW
HEANMSGDK
--
I
D
HG
G
CV
N
T
LT
TLR
PSP
-
LAK
GNPQHTN
LV
E
IEK
I
fig|670897.3.peg.2336
Escherichia coli 2362-75 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
T
D
SIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|216593.1.peg.356
Escherichia coli E2348/69 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
T
D
SIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|585397.7.peg.1776
Escherichia coli ED1a (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
T
D
SIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|585397.9.peg.1771
Escherichia coli ED1a (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
T
D
SIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|574521.7.peg.1709
Escherichia coli O127:H6 str. E2348/69 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
T
D
SIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|749531.3.peg.4806
Escherichia coli MS 69-1 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
EY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
TI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|1040638.4.peg.3634
Escherichia coli O104:H4 str. LB226692 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
KE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|6666666.5357.peg.2359
Escherichia coli TY-2482 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
KE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|585055.6.peg.1783
Escherichia coli 55989 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
KE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|585055.8.peg.1787
Escherichia coli 55989 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
KE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|344601.3.peg.332
Escherichia coli B171 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
KE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|344601.5.peg.330
Escherichia coli B171 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
KE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|679205.4.peg.1618
Escherichia coli MS 124-1 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
KE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|679205.4.peg.1619
Escherichia coli MS 124-1 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
KE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|749533.3.peg.4938
Escherichia coli MS 84-1 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
KE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|358709.5.peg.1103
Escherichia coli 101-1 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|481805.3.peg.2200
Escherichia coli ATCC 8739 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|481805.6.peg.2193
Escherichia coli ATCC 8739 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|413997.3.peg.1632
Escherichia coli B str. REL606 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|550672.3.peg.2428
Escherichia coli B088 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|550676.3.peg.1892
Escherichia coli B185 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|511693.5.peg.1657
Escherichia coli BL21 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|469008.4.peg.2117
Escherichia coli BL21(DE3) (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|595496.3.peg.1548
Escherichia coli BW2952 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|536056.3.peg.2166
Escherichia coli DH1 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|340186.3.peg.16
Escherichia coli E110019 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|340186.5.peg.17
Escherichia coli E110019 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|331111.12.peg.2082
Escherichia coli E24377A (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|331111.3.peg.4225
Escherichia coli E24377A (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|316401.4.peg.1868
Escherichia coli ETEC H10407 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|316401.4.peg.1869
Escherichia coli ETEC H10407 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|656408.3.peg.1727
Escherichia coli H591 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|656408.3.peg.1728
Escherichia coli H591 (14-807/807)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|83333.1.peg.1574
Escherichia coli K12 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|595495.4.peg.2852
Escherichia coli KO11 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|679207.4.peg.4677
Escherichia coli MS 107-1 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|679207.4.peg.4678
Escherichia coli MS 107-1 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|749538.3.peg.4137
Escherichia coli MS 116-1 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|679206.4.peg.1317
Escherichia coli MS 119-7 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|749540.3.peg.4221
Escherichia coli MS 146-1 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|656443.3.peg.2236
Escherichia coli TA271 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|566546.3.peg.1065
Escherichia coli W (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|566546.4.peg.1740
Escherichia coli W (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|316407.3.peg.1545
Escherichia coli W3110 (14-807/807)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|316385.5.peg.1700
Escherichia coli str. K-12 substr. DH10B (14-807/807)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|316385.7.peg.1745
Escherichia coli str. K-12 substr. DH10B (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|511145.12.peg.1659
Escherichia coli str. K-12 substr. MG1655 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|511145.6.peg.1643
Escherichia coli str. K-12 substr. MG1655 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|656414.3.peg.1890
Escherichia coli H736 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TK
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|656414.3.peg.1891
Escherichia coli H736 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TK
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|679204.3.peg.505
Escherichia coli MS 145-7 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
V
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|585396.4.peg.2137
Escherichia coli O111:H- str. 11128 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
V
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|573235.3.peg.2330
Escherichia coli O26:H11 str. 11368 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
V
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|525281.3.peg.975
Escherichia coli 83972 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWL
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
PR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTI
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|655817.3.peg.1869
Escherichia coli ABU 83972 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWL
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
PR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTI
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|655817.3.peg.1870
Escherichia coli ABU 83972 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWL
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
PR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTI
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|656437.3.peg.1799
Escherichia coli TA143 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
EY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
H
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
TI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|656437.3.peg.1800
Escherichia coli TA143 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
EY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
H
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
TI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|749545.3.peg.5107
Escherichia coli MS 182-1 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEVP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
KE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|749532.3.peg.1356
Escherichia coli MS 78-1 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEVP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
KE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|749532.3.peg.1357
Escherichia coli MS 78-1 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEVP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
KE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|670888.3.peg.75
Escherichia coli 1827-70 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEVP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|562.375.peg.1687
Escherichia coli EC4100B (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEVP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|562.375.peg.1688
Escherichia coli EC4100B (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEVP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|331112.3.peg.1564
Escherichia coli HS (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEVP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|331112.6.peg.1631
Escherichia coli HS (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEVP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|409438.11.peg.1856
Escherichia coli SE11 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEVP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|199310.1.peg.1916
Escherichia coli CFT073 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWL
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
PR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|199310.4.peg.1847
Escherichia coli CFT073 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWL
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
PR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|749546.3.peg.3878
Escherichia coli MS 185-1 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWL
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
PR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|749528.3.peg.3856
Escherichia coli MS 45-1 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWL
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
PR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|749548.3.peg.4735
Escherichia coli MS 196-1 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
V
KRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|585034.4.peg.1622
Escherichia coli IAI1 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QNDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|585034.5.peg.1617
Escherichia coli IAI1 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QNDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|656393.3.peg.2376
Escherichia coli H299 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
I
I
SDNLRRIL
K
EY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
TI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|749527.3.peg.4300
Escherichia coli MS 21-1 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAETP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
TI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
T
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|216592.1.peg.2170
Escherichia coli 042 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAETP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
TI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|216592.3.peg.1806
Escherichia coli 042 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAETP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
TI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|550677.3.peg.2970
Escherichia coli B354 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAETP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
TI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|585057.4.peg.1536
Escherichia coli IAI39 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GAI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
TI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|585057.6.peg.1536
Escherichia coli IAI39 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GAI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
TI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|562.371.peg.4431
Escherichia coli 1044A (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|562.373.peg.5333
Escherichia coli 1125A (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|562.372.peg.4663
Escherichia coli 1212A (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|562.372.peg.4664
Escherichia coli 1212A (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|562.374.peg.4446
Escherichia coli 536A (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|83334.1.peg.2323
Escherichia coli O157:H7 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|444454.5.peg.5572
Escherichia coli O157:H7 str. EC4024 (14-807/807)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|444449.5.peg.518
Escherichia coli O157:H7 str. EC4042 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|444448.5.peg.4826
Escherichia coli O157:H7 str. EC4045 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|444453.5.peg.4691
Escherichia coli O157:H7 str. EC4076 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|444452.5.peg.3535
Escherichia coli O157:H7 str. EC4113 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|444450.8.peg.2338
Escherichia coli O157:H7 str. EC4115 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|444451.5.peg.3358
Escherichia coli O157:H7 str. EC4196 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|444447.5.peg.5163
Escherichia coli O157:H7 str. EC4206 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|478004.5.peg.4147
Escherichia coli O157:H7 str. EC4401 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|478005.5.peg.5248
Escherichia coli O157:H7 str. EC4486 (14-807/807)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|478006.5.peg.4086
Escherichia coli O157:H7 str. EC4501 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|478007.5.peg.3502
Escherichia coli O157:H7 str. EC508 (14-807/807)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|478008.5.peg.4498
Escherichia coli O157:H7 str. EC869 (14-807/807)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|637388.3.peg.5056
Escherichia coli O157:H7 str. FRIK2000 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|570506.3.peg.4177
Escherichia coli O157:H7 str. FRIK966 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|386585.9.peg.2402
Escherichia coli O157:H7 str. Sakai (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|544404.4.peg.2201
Escherichia coli O157:H7 str. TW14359 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|502346.5.peg.5111
Escherichia coli O157:H7 str. TW14588 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|656379.3.peg.2056
Escherichia coli FVEC1302 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEVP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
H
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
TI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|656380.3.peg.3019
Escherichia coli FVEC1412 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEVP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
H
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
TI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|749549.3.peg.5226
Escherichia coli MS 198-1 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEVP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
H
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
TI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|585056.7.peg.2060
Escherichia coli UMN026 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEVP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
H
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
TI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|405955.13.peg.1671
Escherichia coli APEC O1 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
PR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|405955.9.peg.1356
Escherichia coli APEC O1 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
PR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|714962.3.peg.1739
Escherichia coli IHE3034 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
PR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|585035.6.peg.1626
Escherichia coli S88 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
PR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|869729.3.peg.1959
Escherichia coli UM146 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
PR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|364106.7.peg.1818
Escherichia coli UTI89 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
PR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|364106.8.peg.1821
Escherichia coli UTI89 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
PR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|340185.3.peg.3274
Escherichia coli E22 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
R
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
KE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|340185.4.peg.3450
Escherichia coli E22 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
R
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
KE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|585395.4.peg.1811
Escherichia coli O103:H2 str. 12009 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
LIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
KE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|749537.3.peg.2398
Escherichia coli MS 115-1 (5-798/798)
ISRR
N
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAETP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
I
I
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWV
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|701177.3.peg.1979
Escherichia coli O55:H7 str. CB9615 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAETP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|656444.3.peg.2478
Escherichia coli TA280 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
I
I
SDNLRRIL
K
EY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
S
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
TI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|656417.3.peg.2078
Escherichia coli M605 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
S
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
TI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRGTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|656417.3.peg.2079
Escherichia coli M605 (14-807/807)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
S
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWILS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
TI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRGTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|340184.3.peg.1014
Escherichia coli B7A (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YRVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
V
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|753642.3.peg.1575
Escherichia coli NC101 (5-798/798)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAQAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
TE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LA
L
E
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
SRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWL
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
PR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTH
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNSE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
HY
VA
F
--
RA
FR
V
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHR
PSP
-
LAK
GNPSHSN
LV
Q
IEKV
fig|155864.1.peg.2331
Escherichia coli O157:H7 EDL933 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
XRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
XY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHX
PSP
-
L
X
K
GNPSHSN
LV
Q
IEKV
fig|155864.8.peg.2170
Escherichia coli O157:H7 EDL933 (15-808/808)
ISRR
S
LMK
T
SA
--
L
G
SL
A
L
A
SSAFT
LPF
SQMVRAAEAP-
-
-
--
V-E---E
K
AV
----
W
S
-
S
CTVN
CG
SR
C
L
L
R
L
H
V
K
D
DT
V
YWVES--
D
T
T
GDDV
Y
-
G
N
HQVR
A
C
LR
G
RSIRRR
M
N
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
L
D
T
I
SDNLRRIL
K
DY
GNEA
V
HVLYG
TG
--------------
VD
G
GNI
T
NS----NV-PY
R
L
MN
SC
GG
FLSRY
G
S
YS
T
--
A
Q
I
SAAMSYMF
G
A-NDGNSPD
D
----
I
A
N
T
KL
VV
M
FG
N
NP
A
ET
RM
S
G
------
G
G
VT
Y
YV
E
-QA
R
ER
SN
A
-
RM
I
V
IDP
R
Y
ND
T
AA
--
G
RE
D
-
E
W
L
PIR
PGTD
G
AL
ACA
IA
WV
LI
SE
N
MV
DQ
P
FL
D
KY
C
--------
V
GY
-------------
DEKTLPANAPRNAH
YKAYI
L
G
E
G
P
D
GIA
KT
PE
WAA
K
IT
SI
P
AE
K
I
I
Q
LARE
I
G
SAK
P
AY
I
CQ
GW
--
G
P
QRH
SN
GE
QT
---
XRA
I
AM
L
SV
LTG
N
VG
IN
G
-
G
---
NS
G
-----VREGSWDLGVEWF
P
M
------------------
L
-
ENPVK
T
Q
I
SVFTWTD
A
IDH
G
TE
MTA
TR
-----
DG
V
---------
R
GK
EKLDVP
IK
FL
W
CY
A
S
N
TLI
-----------------------
N
Q
H
GDI
N
HTN
E
V
L
QDDS
KC
-
E
M
IV
G
ID
H
F
M
T
A
SAK
Y
C
DILLP
DL
M
PT
EQ
E
D
LISHESA
GN
MG--YVILA
Q
PA
TSAK
FE
R
K
P
I
YWMLS
E
V
AKRLGP
DVY
Q
T
FTE
----------
GR
SQHE
W
I
-------------------------------
K
Y
L
H
--
A
KTKERNPE--
M
P
D
Y
E
EMKTT
-
-
GI
-FKKKCPE
E
XY
VA
F
--
RA
FR
E
DP
QA
N
-----
P
L
-
K
TPSGKIEIYS
ER
LA
KI
A
D
TWEL
KKDEI
I
H
PLP
A
Y
TPG
F
DGWDD
-----------------
PLRKTYP
L
----
QL
T
G
F
H
YKA
R
T
HS
S
-
YGNIDV
L
QQ----
A
CPQE
V
W
INP
I
DA
QA
RGI
RH
GD
T
VRV
F
N
N
N
GE
M
LIA
A
K
VT
P
R
IL
PGV
TAIG
QGAW
LKADMFGDR
--
V
D
HG
G
SI
N
I
LT
SHX
PSP
-
L
X
K
GNPSHSN
LV
Q
IEKV
fig|656379.3.peg.1743
Escherichia coli FVEC1302 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
Q
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|656380.3.peg.1571
Escherichia coli FVEC1412 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
Q
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749549.3.peg.5326
Escherichia coli MS 198-1 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
Q
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|585056.7.peg.1282
Escherichia coli UMN026 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
Q
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|679206.4.peg.3406
Escherichia coli MS 119-7 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PQ
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|656443.3.peg.1179
Escherichia coli TA271 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PQ
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|362663.8.peg.918
Escherichia coli 536 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QE
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
SN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|362663.9.peg.918
Escherichia coli 536 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QE
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
SN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|340197.3.peg.2200
Escherichia coli F11 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QE
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
SN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|340197.5.peg.2314
Escherichia coli F11 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QE
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
SN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749550.3.peg.2131
Escherichia coli MS 200-1 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QE
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
SN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|656437.3.peg.1030
Escherichia coli TA143 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
DVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|655817.3.peg.985
Escherichia coli ABU 83972 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
SN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|199310.1.peg.1003
Escherichia coli CFT073 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
SN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749528.3.peg.1712
Escherichia coli MS 45-1 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
SN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|753642.3.peg.709
Escherichia coli NC101 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
SN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|685038.3.peg.828
Escherichia coli O83:H1 str. NRG 857C (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
SN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|656440.3.peg.808
Escherichia coli TA206 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
SN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|562.376.peg.4705
Escherichia coli WV_060327 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
KK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
SN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|344601.3.peg.2709
Escherichia coli B171 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|340185.3.peg.3053
Escherichia coli E22 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|340185.4.peg.3218
Escherichia coli E22 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749545.3.peg.4319
Escherichia coli MS 182-1 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749531.3.peg.2922
Escherichia coli MS 69-1 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749532.3.peg.782
Escherichia coli MS 78-1 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|585395.4.peg.987
Escherichia coli O103:H2 str. 12009 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|656444.3.peg.1511
Escherichia coli TA280 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|358709.5.peg.3408
Escherichia coli 101-1 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|670888.3.peg.1509
Escherichia coli 1827-70 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|344610.3.peg.3941
Escherichia coli 53638 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|344610.7.peg.770
Escherichia coli 53638 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|481805.3.peg.2902
Escherichia coli ATCC 8739 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|550676.3.peg.362
Escherichia coli B185 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|536056.3.peg.2902
Escherichia coli DH1 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|316401.4.peg.1107
Escherichia coli ETEC H10407 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|656414.3.peg.1101
Escherichia coli H736 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|331112.3.peg.927
Escherichia coli HS (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|331112.6.peg.966
Escherichia coli HS (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|83333.1.peg.879
Escherichia coli K12 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749538.3.peg.2886
Escherichia coli MS 116-1 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749540.3.peg.2700
Escherichia coli MS 146-1 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749544.3.peg.632
Escherichia coli MS 175-1 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749547.3.peg.1841
Escherichia coli MS 187-1 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749548.3.peg.2260
Escherichia coli MS 196-1 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|316407.3.peg.860
Escherichia coli W3110 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|511145.12.peg.924
Escherichia coli str. K-12 substr. MG1655 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|562.371.peg.2141
Escherichia coli 1044A (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSGE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|562.373.peg.1124
Escherichia coli 1125A (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSGE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|562.372.peg.990
Escherichia coli 1212A (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSGE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|562.374.peg.2523
Escherichia coli 536A (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSGE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|83334.1.peg.1047
Escherichia coli O157:H7 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSGE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|444454.5.peg.5475
Escherichia coli O157:H7 str. EC4024 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSGE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|444449.5.peg.4408
Escherichia coli O157:H7 str. EC4042 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSGE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|444448.5.peg.3684
Escherichia coli O157:H7 str. EC4045 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSGE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|444453.5.peg.5057
Escherichia coli O157:H7 str. EC4076 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSGE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|444452.5.peg.4998
Escherichia coli O157:H7 str. EC4113 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSGE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|444450.8.peg.1141
Escherichia coli O157:H7 str. EC4115 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSGE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|444451.5.peg.3774
Escherichia coli O157:H7 str. EC4196 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSGE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|444447.5.peg.3891
Escherichia coli O157:H7 str. EC4206 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSGE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|478004.5.peg.3678
Escherichia coli O157:H7 str. EC4401 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSGE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|478006.5.peg.3407
Escherichia coli O157:H7 str. EC4501 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSGE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|478007.5.peg.4035
Escherichia coli O157:H7 str. EC508 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSGE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|478008.5.peg.2563
Escherichia coli O157:H7 str. EC869 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSGE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|637388.3.peg.4472
Escherichia coli O157:H7 str. FRIK2000 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSGE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|570506.3.peg.2034
Escherichia coli O157:H7 str. FRIK966 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSGE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|386585.9.peg.1096
Escherichia coli O157:H7 str. Sakai (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSGE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|544404.4.peg.1007
Escherichia coli O157:H7 str. TW14359 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSGE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|502346.5.peg.193
Escherichia coli O157:H7 str. TW14588 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSGE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|701177.3.peg.1112
Escherichia coli O55:H7 str. CB9615 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSGE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|340184.3.peg.2686
Escherichia coli B7A (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|340184.6.peg.2809
Escherichia coli B7A (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|562.375.peg.4543
Escherichia coli EC4100B (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|595495.4.peg.3357
Escherichia coli KO11 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|679204.3.peg.2432
Escherichia coli MS 145-7 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|585396.4.peg.1002
Escherichia coli O111:H- str. 11128 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|566546.3.peg.1883
Escherichia coli W (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|566546.4.peg.992
Escherichia coli W (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|656393.3.peg.1656
Escherichia coli H299 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
LPAKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749527.3.peg.2432
Escherichia coli MS 21-1 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
LPAKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|439855.10.peg.2382
Escherichia coli SMS-3-5 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
LPAKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|216592.1.peg.227
Escherichia coli 042 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AV
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|869729.3.peg.2789
Escherichia coli UM146 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|656417.3.peg.1134
Escherichia coli M605 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
II
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|1040638.4.peg.4742
Escherichia coli O104:H4 str. LB226692 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NT
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|6666666.5357.peg.773
Escherichia coli TY-2482 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NT
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|585055.8.peg.956
Escherichia coli 55989 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NT
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|679207.4.peg.2010
Escherichia coli MS 107-1 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PQ
WA
S
Q
ITG
I
P
AE
K
I
I
Q
LARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|409438.11.peg.1082
Escherichia coli SE11 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PQ
WA
S
Q
ITG
I
P
AE
K
I
I
Q
LARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|656408.3.peg.952
Escherichia coli H591 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PQ
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
EKPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|656419.3.peg.1188
Escherichia coli M718 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
K
S
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|340186.3.peg.3976
Escherichia coli E110019 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
LSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|331111.3.peg.3466
Escherichia coli E24377A (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MT
E
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|679205.4.peg.1027
Escherichia coli MS 124-1 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PQ
WA
S
Q
ITG
I
P
AE
K
I
I
Q
LARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NT
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749533.3.peg.1023
Escherichia coli MS 84-1 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PQ
WA
S
Q
ITG
I
P
AE
K
I
I
Q
LARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NT
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749546.3.peg.1788
Escherichia coli MS 185-1 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
I
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
D
I
I
ATKMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
X
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
SN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--TKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|749537.3.peg.4337
Escherichia coli MS 115-1 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDSA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
G
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
A
FL
D
KY
C
--------
V
GY
-------------
DEKTLPASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
V
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
HN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|670897.3.peg.4690
Escherichia coli 2362-75 (14-814/814)
V
SRR
G
L
V
K
T
T
A
--
IG
GL
A
M
A
SSALT
LPF
SRIAHAVDRA-
-
-
--
IPTKSDE
K
VI
----
W
S
-
A
CTVN
CG
SR
C
P
L
R
M
H
V
V
D
GE
I
KYVET--
D
N
T
GDDN
Y
D
G
L
HQVR
A
C
LR
G
RSMRRR
VY
NP
DRL
KY
PM
K
R
VG
-----------
A
RG
----
EG
K
F
ER
ISW
E
EA
Y
G
I
I
ATNMQRLI
K
EY
GNE
S
I
YLNYG
TG
--------------
TL
G
GTM
T
RSWPPGNTLVA
R
L
MN
CC
GG
YLNHY
G
D
YS
S
--
A
Q
I
AEGLNYTY
G
GWADGNSPS
D
----
IENS
KL
VVLFG
N
NP
G
ET
RM
S
G
------
G
G
VT
Y
YL
E
-QA
R
QK
SN
A
-
RM
I
I
IDP
R
Y
TD
T
GA
--
G
RE
D
-
E
WI
PIR
PGTD
A
AL
VNG
L
A
YV
M
I
TE
N
LV
DQ
E
FL
D
KY
C
--------
V
GY
-------------
DEKTLSASAPKNGH
YKAYI
L
G
E
G
P
D
GVA
KT
PE
WA
S
Q
ITGVP
AD
K
I
I
KLARE
I
G
STK
P
AF
I
SQ
GW
--
G
P
QRH
AN
GE
IA
---
TRA
I
SM
L
AI
LTG
N
VG
IN
G
-
G
---
NS
G
-----AREGSYSLPFVRM
P
T
------------------
L
-
ENPIQ
T
S
I
SMFMWTD
A
IER
G
PE
MTA
LR
-----
DG
V
---------
R
GK
DKLDVP
IK
MI
W
NY
A
G
N
CLI
-----------------------
N
Q
H
SEI
N
RTH
E
I
L
QDDK
KC
-
E
L
IV
A
ID
C
H
M
T
S
SAK
Y
ADILLP
DC
T
AS
EQ
M
D
FALDASC
GN
MS--YVIFN
D
QV
IKPR
FE
C
K
T
I
YEMTS
E
L
AKRLG
-
-VE
Q
Q
FTE
----------
GR
TQEE
W
M
-------------------------------
R
H
LY
--
A
QSREAIPE--
LP
T
F
E
EFRKQ
-
-
GI
-FKKRDPQ
G
HH
VAY
--
KA
FR
E
DP
QA
N
-----
P
L
-
T
TPSGKIEIYS
QA
LA
DI
A
A
TWEL
PEGDV
I
D
PLP
I
Y
TPG
F
ESYQD
-----------------
PLNKQYP
L
----
QL
T
G
F
H
YKS
R
V
HS
T
-
YGNVDV
L
KA----
A
CRQE
M
W
INP
L
DA
QK
RGI
NN
GD
K
VR
I
F
N
D
RGEV
HIE
A
K
VT
P
R
MM
PGV
VALG
E
GAW
YDPD--AKR
--
V
D
KG
G
CI
N
V
LT
TQR
PSP
-
LAK
GNPSHTN
LV
Q
V
EKV
fig|550676.3.peg.1721
Escherichia coli B185 (15-792/793)
V
SRR
S
F
LQ
A
T
-
--
--
--
-
-
-
SALIT
LPF
ISSTAKAQSPD
A
S
PE
VTAPVAD
K
VV
----
P
T
-
C
STFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
TQITTLP
D
N
E
LDPQ
M
-
-
-
PI
M
R
A
C
VR
G
RGYRKF
VY
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVHVG
T
A
--------------
VS
G
GTF
S
-----GDAMAR
R
L
L
N
LT
GG
YLEYY
H
S
V
S
L
--
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
------
G
H
TN
Y
FF
Q
-KM
K
Q-
N
G
T
-
RF
I
V
V
DP
R
Y
SD
T
VS
--
S
LA
D
-
Q
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
-------------
DENSMPEGVPANES
LV
AY
L
F
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LAR
D
Y
A
TTK
P
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
D
------------------
M
P
ENPVQ
A
K
I
SIMNWMQ
A
ADD
A
SK
V
T
P
-Q
-----
DG
L
---------
K
G
V
DKLDSN
I
R
LL
F
SL
A
G
N
YLA
-----------------------
N
Q
N
PDV
H
QAA
K
L
L
EDES
K
I
-
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETW
G
T
AS--YLILS
EKL
IEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
LG
-
-VE
A
E
F
SQ
----------
GR
DEKQ
W
I
-------------------------------
E
H
IW
--
E
QTRLAMPDEN
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
F
DM
-
-
----
-QDPE
I
P
A
L
S
H
Y
VPA
F
EGPED
-----------------
KLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YAN-PW
L
QE----
V
QTQK
L
W
L
NP
Q
DA
KQ
RGI
VE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VAMQ
A
GAW
WQPD--AQG
--
I
D
RG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|478008.5.peg.3072
Escherichia coli O157:H7 str. EC869 (15-792/793)
V
SRR
S
F
LQ
A
T
-
--
--
--
-
-
-
SALIT
LPF
ISSTAKAQSPD
A
S
PE
VTAPVAD
K
VV
----
P
T
-
C
STFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
TQITTLP
D
N
E
LDPQ
M
-
-
-
PI
M
R
A
C
VR
G
RGYRKF
VY
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVHVG
T
A
--------------
VS
G
GTF
S
-----GDAMAR
R
L
L
N
LT
GG
YLEYY
H
S
V
S
L
--
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
------
G
H
TN
Y
YF
Q
-KM
K
Q-
N
G
T
-
RF
I
V
V
DP
R
Y
SD
T
VS
--
S
LA
D
-
Q
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
-------------
DENSMPEGVPANES
LV
AY
L
F
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LAR
D
Y
A
TTK
P
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
D
------------------
M
P
ENPVQ
A
K
I
SIMNWMQ
A
ADD
A
SK
V
T
P
-Q
-----
DG
L
---------
K
G
V
DKLDSN
I
R
LL
F
SL
A
G
N
YLA
-----------------------
N
Q
N
PDV
H
QAA
K
L
L
EDES
K
I
-
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETW
G
T
AS--YLILS
EKL
IEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
LG
-
-VE
A
E
F
SQ
----------
GR
DEKQ
W
I
-------------------------------
E
H
IW
--
E
QTRLAMPDEN
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
F
DM
-
-
----
-QDPE
I
P
A
L
S
H
Y
VPA
F
EGPED
-----------------
KLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YAN-PW
L
QE----
V
QTQK
L
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VAMQ
A
GAW
WQPD--AQG
--
I
D
RG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|637388.3.peg.75
Escherichia coli O157:H7 str. FRIK2000 (15-792/793)
V
SRR
S
F
LQ
A
T
-
--
--
--
-
-
-
SALIT
LPF
ISSTAKAQSPD
A
S
PE
VTAPVAD
K
VV
----
P
T
-
C
STFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
TQITTLP
D
N
E
LDPQ
M
-
-
-
PI
M
R
A
C
VR
G
RGYRKF
VY
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVHVG
T
A
--------------
VS
G
GTF
S
-----GDAMAR
R
L
L
N
LT
GG
YLEYY
H
S
V
S
L
--
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
------
G
H
TN
Y
YF
Q
-KM
K
Q-
N
G
T
-
RF
I
V
V
DP
R
Y
SD
T
VS
--
S
LA
D
-
Q
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
-------------
DENSMPEGVPANES
LV
AY
L
F
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LAR
D
Y
A
TTK
P
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
D
------------------
M
P
ENPVQ
A
K
I
SIMNWMQ
A
ADD
A
SK
V
T
P
-Q
-----
DG
L
---------
K
G
V
DKLDSN
I
R
LL
F
SL
A
G
N
YLA
-----------------------
N
Q
N
PDV
H
QAA
K
L
L
EDES
K
I
-
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETW
G
T
AS--YLILS
EKL
IEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
LG
-
-VE
A
E
F
SQ
----------
GR
DEKQ
W
I
-------------------------------
E
H
IW
--
E
QTRLAMPDEN
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
F
DM
-
-
----
-QDPE
I
P
A
L
S
H
Y
VPA
F
EGPED
-----------------
KLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YAN-PW
L
QE----
V
QTQK
L
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VAMQ
A
GAW
WQPD--AQG
--
I
D
RG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|570506.3.peg.5258
Escherichia coli O157:H7 str. FRIK966 (15-792/793)
V
SRR
S
F
LQ
A
T
-
--
--
--
-
-
-
SALIT
LPF
ISSTAKAQSPD
A
S
PE
VTAPVAD
K
VV
----
P
T
-
C
STFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
TQITTLP
D
N
E
LDPQ
M
-
-
-
PI
M
R
A
C
VR
G
RGYRKF
VY
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVHVG
T
A
--------------
VS
G
GTF
S
-----GDAMAR
R
L
L
N
LT
GG
YLEYY
H
S
V
S
L
--
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
------
G
H
TN
Y
YF
Q
-KM
K
Q-
N
G
T
-
RF
I
V
V
DP
R
Y
SD
T
VS
--
S
LA
D
-
Q
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
-------------
DENSMPEGVPANES
LV
AY
L
F
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LAR
D
Y
A
TTK
P
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
D
------------------
M
P
ENPVQ
A
K
I
SIMNWMQ
A
ADD
A
SK
V
T
P
-Q
-----
DG
L
---------
K
G
V
DKLDSN
I
R
LL
F
SL
A
G
N
YLA
-----------------------
N
Q
N
PDV
H
QAA
K
L
L
EDES
K
I
-
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETW
G
T
AS--YLILS
EKL
IEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
LG
-
-VE
A
E
F
SQ
----------
GR
DEKQ
W
I
-------------------------------
E
H
IW
--
E
QTRLAMPDEN
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
F
DM
-
-
----
-QDPE
I
P
A
L
S
H
Y
VPA
F
EGPED
-----------------
KLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YAN-PW
L
QE----
V
QTQK
L
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VAMQ
A
GAW
WQPD--AQG
--
I
D
RG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|155864.1.peg.3383
Escherichia coli O157:H7 EDL933 (15-792/793)
V
SRR
S
F
LQ
A
T
-
--
--
--
-
-
-
SALIT
LPF
ISSTAKAQSPD
A
S
PE
VTAPVAD
K
VV
----
P
T
-
C
STFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
TQITTLP
D
N
E
LDPQ
M
-
-
-
PI
M
R
A
C
VR
G
RGYRKF
VY
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVHVG
T
A
--------------
VX
G
GTF
S
-----GDAMAR
R
L
L
N
LT
GG
YLEYY
H
S
V
S
L
--
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
------
G
H
TN
Y
YF
Q
-KM
K
Q-
N
G
T
-
RF
I
V
V
DP
R
Y
SD
T
VS
--
S
LA
D
-
Q
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
-------------
DENSMPEGVPANES
LV
AY
L
F
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LAR
D
Y
A
TTK
P
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
D
------------------
M
P
ENPVQ
A
K
I
SIMNWMQ
A
ADD
A
SK
V
T
P
-Q
-----
DG
L
---------
K
G
V
DKLDSN
I
R
LL
F
SL
A
G
N
YLA
-----------------------
N
Q
N
PDV
H
QAA
K
L
L
EDES
K
I
-
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETW
G
T
AS--YLILS
EK
P
IEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
LG
-
-VE
A
E
F
SQ
----------
GR
DEKQ
W
I
-------------------------------
E
H
IW
--
E
QTRLAMPDEN
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
F
DM
-
-
----
-QDPE
I
P
A
L
S
H
Y
VPA
F
EGPED
-----------------
KLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YAN-PW
L
QE----
V
QTQK
L
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VAMQ
A
GAW
WQPD--AQG
--
I
D
RG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|562.373.peg.3712
Escherichia coli 1125A (15-792/793)
V
SRR
S
F
LQ
A
T
-
--
--
--
-
-
-
SALIT
LPF
ISSTAKAQSPD
A
S
PE
VTAPVAD
K
VV
----
P
T
-
C
STFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
TQITTLP
D
N
E
LDPQ
M
-
-
-
PI
M
R
A
C
VR
G
RGYRKF
VY
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVHVG
T
A
--------------
VS
G
GTF
S
-----GDAMAR
R
L
L
N
LT
GG
YLEYY
H
S
V
S
L
--
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
------
G
H
TN
Y
YF
Q
-KM
K
Q-
N
G
T
-
RF
I
V
V
DP
R
Y
SD
T
VS
--
S
LA
D
-
Q
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
-------------
DENSMPEGVPANES
LV
AY
L
F
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LAR
D
Y
A
TTK
P
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
D
------------------
M
P
ENPVQ
A
K
I
SIMNWMQ
A
ADD
A
SK
V
T
P
-Q
-----
DG
L
---------
K
G
V
DKLDSN
I
R
LL
F
SL
A
G
N
YLA
-----------------------
N
Q
N
PDV
H
QAA
K
L
L
EDES
K
I
-
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETW
G
T
AS--YLILS
EK
P
IEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
LG
-
-VE
A
E
F
SQ
----------
GR
DEKQ
W
I
-------------------------------
E
H
IW
--
E
QTRLAMPDEN
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
F
DM
-
-
----
-QDPE
I
P
A
L
S
H
Y
VPA
F
EGPED
-----------------
KLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YAN-PW
L
QE----
V
QTQK
L
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VAMQ
A
GAW
WQPD--AQG
--
I
D
RG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|83334.1.peg.3383
Escherichia coli O157:H7 (15-792/793)
V
SRR
S
F
LQ
A
T
-
--
--
--
-
-
-
SALIT
LPF
ISSTAKAQSPD
A
S
PE
VTAPVAD
K
VV
----
P
T
-
C
STFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
TQITTLP
D
N
E
LDPQ
M
-
-
-
PI
M
R
A
C
VR
G
RGYRKF
VY
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVHVG
T
A
--------------
VS
G
GTF
S
-----GDAMAR
R
L
L
N
LT
GG
YLEYY
H
S
V
S
L
--
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
------
G
H
TN
Y
YF
Q
-KM
K
Q-
N
G
T
-
RF
I
V
V
DP
R
Y
SD
T
VS
--
S
LA
D
-
Q
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
-------------
DENSMPEGVPANES
LV
AY
L
F
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LAR
D
Y
A
TTK
P
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
D
------------------
M
P
ENPVQ
A
K
I
SIMNWMQ
A
ADD
A
SK
V
T
P
-Q
-----
DG
L
---------
K
G
V
DKLDSN
I
R
LL
F
SL
A
G
N
YLA
-----------------------
N
Q
N
PDV
H
QAA
K
L
L
EDES
K
I
-
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETW
G
T
AS--YLILS
EK
P
IEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
LG
-
-VE
A
E
F
SQ
----------
GR
DEKQ
W
I
-------------------------------
E
H
IW
--
E
QTRLAMPDEN
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
F
DM
-
-
----
-QDPE
I
P
A
L
S
H
Y
VPA
F
EGPED
-----------------
KLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YAN-PW
L
QE----
V
QTQK
L
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VAMQ
A
GAW
WQPD--AQG
--
I
D
RG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|444454.5.peg.2406
Escherichia coli O157:H7 str. EC4024 (15-792/793)
V
SRR
S
F
LQ
A
T
-
--
--
--
-
-
-
SALIT
LPF
ISSTAKAQSPD
A
S
PE
VTAPVAD
K
VV
----
P
T
-
C
STFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
TQITTLP
D
N
E
LDPQ
M
-
-
-
PI
M
R
A
C
VR
G
RGYRKF
VY
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVHVG
T
A
--------------
VS
G
GTF
S
-----GDAMAR
R
L
L
N
LT
GG
YLEYY
H
S
V
S
L
--
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
------
G
H
TN
Y
YF
Q
-KM
K
Q-
N
G
T
-
RF
I
V
V
DP
R
Y
SD
T
VS
--
S
LA
D
-
Q
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
-------------
DENSMPEGVPANES
LV
AY
L
F
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LAR
D
Y
A
TTK
P
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
D
------------------
M
P
ENPVQ
A
K
I
SIMNWMQ
A
ADD
A
SK
V
T
P
-Q
-----
DG
L
---------
K
G
V
DKLDSN
I
R
LL
F
SL
A
G
N
YLA
-----------------------
N
Q
N
PDV
H
QAA
K
L
L
EDES
K
I
-
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETW
G
T
AS--YLILS
EK
P
IEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
LG
-
-VE
A
E
F
SQ
----------
GR
DEKQ
W
I
-------------------------------
E
H
IW
--
E
QTRLAMPDEN
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
F
DM
-
-
----
-QDPE
I
P
A
L
S
H
Y
VPA
F
EGPED
-----------------
KLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YAN-PW
L
QE----
V
QTQK
L
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VAMQ
A
GAW
WQPD--AQG
--
I
D
RG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|444449.5.peg.1872
Escherichia coli O157:H7 str. EC4042 (15-792/793)
V
SRR
S
F
LQ
A
T
-
--
--
--
-
-
-
SALIT
LPF
ISSTAKAQSPD
A
S
PE
VTAPVAD
K
VV
----
P
T
-
C
STFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
TQITTLP
D
N
E
LDPQ
M
-
-
-
PI
M
R
A
C
VR
G
RGYRKF
VY
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVHVG
T
A
--------------
VS
G
GTF
S
-----GDAMAR
R
L
L
N
LT
GG
YLEYY
H
S
V
S
L
--
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
------
G
H
TN
Y
YF
Q
-KM
K
Q-
N
G
T
-
RF
I
V
V
DP
R
Y
SD
T
VS
--
S
LA
D
-
Q
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
-------------
DENSMPEGVPANES
LV
AY
L
F
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LAR
D
Y
A
TTK
P
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
D
------------------
M
P
ENPVQ
A
K
I
SIMNWMQ
A
ADD
A
SK
V
T
P
-Q
-----
DG
L
---------
K
G
V
DKLDSN
I
R
LL
F
SL
A
G
N
YLA
-----------------------
N
Q
N
PDV
H
QAA
K
L
L
EDES
K
I
-
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETW
G
T
AS--YLILS
EK
P
IEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
LG
-
-VE
A
E
F
SQ
----------
GR
DEKQ
W
I
-------------------------------
E
H
IW
--
E
QTRLAMPDEN
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
F
DM
-
-
----
-QDPE
I
P
A
L
S
H
Y
VPA
F
EGPED
-----------------
KLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YAN-PW
L
QE----
V
QTQK
L
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VAMQ
A
GAW
WQPD--AQG
--
I
D
RG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|444448.5.peg.626
Escherichia coli O157:H7 str. EC4045 (15-792/793)
V
SRR
S
F
LQ
A
T
-
--
--
--
-
-
-
SALIT
LPF
ISSTAKAQSPD
A
S
PE
VTAPVAD
K
VV
----
P
T
-
C
STFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
TQITTLP
D
N
E
LDPQ
M
-
-
-
PI
M
R
A
C
VR
G
RGYRKF
VY
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVHVG
T
A
--------------
VS
G
GTF
S
-----GDAMAR
R
L
L
N
LT
GG
YLEYY
H
S
V
S
L
--
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
------
G
H
TN
Y
YF
Q
-KM
K
Q-
N
G
T
-
RF
I
V
V
DP
R
Y
SD
T
VS
--
S
LA
D
-
Q
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
-------------
DENSMPEGVPANES
LV
AY
L
F
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LAR
D
Y
A
TTK
P
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
D
------------------
M
P
ENPVQ
A
K
I
SIMNWMQ
A
ADD
A
SK
V
T
P
-Q
-----
DG
L
---------
K
G
V
DKLDSN
I
R
LL
F
SL
A
G
N
YLA
-----------------------
N
Q
N
PDV
H
QAA
K
L
L
EDES
K
I
-
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETW
G
T
AS--YLILS
EK
P
IEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
LG
-
-VE
A
E
F
SQ
----------
GR
DEKQ
W
I
-------------------------------
E
H
IW
--
E
QTRLAMPDEN
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
F
DM
-
-
----
-QDPE
I
P
A
L
S
H
Y
VPA
F
EGPED
-----------------
KLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YAN-PW
L
QE----
V
QTQK
L
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VAMQ
A
GAW
WQPD--AQG
--
I
D
RG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|444453.5.peg.107
Escherichia coli O157:H7 str. EC4076 (15-792/793)
V
SRR
S
F
LQ
A
T
-
--
--
--
-
-
-
SALIT
LPF
ISSTAKAQSPD
A
S
PE
VTAPVAD
K
VV
----
P
T
-
C
STFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
TQITTLP
D
N
E
LDPQ
M
-
-
-
PI
M
R
A
C
VR
G
RGYRKF
VY
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVHVG
T
A
--------------
VS
G
GTF
S
-----GDAMAR
R
L
L
N
LT
GG
YLEYY
H
S
V
S
L
--
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
------
G
H
TN
Y
YF
Q
-KM
K
Q-
N
G
T
-
RF
I
V
V
DP
R
Y
SD
T
VS
--
S
LA
D
-
Q
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
-------------
DENSMPEGVPANES
LV
AY
L
F
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LAR
D
Y
A
TTK
P
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
D
------------------
M
P
ENPVQ
A
K
I
SIMNWMQ
A
ADD
A
SK
V
T
P
-Q
-----
DG
L
---------
K
G
V
DKLDSN
I
R
LL
F
SL
A
G
N
YLA
-----------------------
N
Q
N
PDV
H
QAA
K
L
L
EDES
K
I
-
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETW
G
T
AS--YLILS
EK
P
IEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
LG
-
-VE
A
E
F
SQ
----------
GR
DEKQ
W
I
-------------------------------
E
H
IW
--
E
QTRLAMPDEN
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
F
DM
-
-
----
-QDPE
I
P
A
L
S
H
Y
VPA
F
EGPED
-----------------
KLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YAN-PW
L
QE----
V
QTQK
L
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VAMQ
A
GAW
WQPD--AQG
--
I
D
RG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|444452.5.peg.1484
Escherichia coli O157:H7 str. EC4113 (15-792/793)
V
SRR
S
F
LQ
A
T
-
--
--
--
-
-
-
SALIT
LPF
ISSTAKAQSPD
A
S
PE
VTAPVAD
K
VV
----
P
T
-
C
STFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
TQITTLP
D
N
E
LDPQ
M
-
-
-
PI
M
R
A
C
VR
G
RGYRKF
VY
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVHVG
T
A
--------------
VS
G
GTF
S
-----GDAMAR
R
L
L
N
LT
GG
YLEYY
H
S
V
S
L
--
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
------
G
H
TN
Y
YF
Q
-KM
K
Q-
N
G
T
-
RF
I
V
V
DP
R
Y
SD
T
VS
--
S
LA
D
-
Q
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
-------------
DENSMPEGVPANES
LV
AY
L
F
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LAR
D
Y
A
TTK
P
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
D
------------------
M
P
ENPVQ
A
K
I
SIMNWMQ
A
ADD
A
SK
V
T
P
-Q
-----
DG
L
---------
K
G
V
DKLDSN
I
R
LL
F
SL
A
G
N
YLA
-----------------------
N
Q
N
PDV
H
QAA
K
L
L
EDES
K
I
-
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETW
G
T
AS--YLILS
EK
P
IEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
LG
-
-VE
A
E
F
SQ
----------
GR
DEKQ
W
I
-------------------------------
E
H
IW
--
E
QTRLAMPDEN
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
F
DM
-
-
----
-QDPE
I
P
A
L
S
H
Y
VPA
F
EGPED
-----------------
KLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YAN-PW
L
QE----
V
QTQK
L
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VAMQ
A
GAW
WQPD--AQG
--
I
D
RG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|444450.8.peg.3715
Escherichia coli O157:H7 str. EC4115 (15-792/793)
V
SRR
S
F
LQ
A
T
-
--
--
--
-
-
-
SALIT
LPF
ISSTAKAQSPD
A
S
PE
VTAPVAD
K
VV
----
P
T
-
C
STFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
TQITTLP
D
N
E
LDPQ
M
-
-
-
PI
M
R
A
C
VR
G
RGYRKF
VY
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVHVG
T
A
--------------
VS
G
GTF
S
-----GDAMAR
R
L
L
N
LT
GG
YLEYY
H
S
V
S
L
--
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
------
G
H
TN
Y
YF
Q
-KM
K
Q-
N
G
T
-
RF
I
V
V
DP
R
Y
SD
T
VS
--
S
LA
D
-
Q
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
-------------
DENSMPEGVPANES
LV
AY
L
F
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LAR
D
Y
A
TTK
P
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
D
------------------
M
P
ENPVQ
A
K
I
SIMNWMQ
A
ADD
A
SK
V
T
P
-Q
-----
DG
L
---------
K
G
V
DKLDSN
I
R
LL
F
SL
A
G
N
YLA
-----------------------
N
Q
N
PDV
H
QAA
K
L
L
EDES
K
I
-
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETW
G
T
AS--YLILS
EK
P
IEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
LG
-
-VE
A
E
F
SQ
----------
GR
DEKQ
W
I
-------------------------------
E
H
IW
--
E
QTRLAMPDEN
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
F
DM
-
-
----
-QDPE
I
P
A
L
S
H
Y
VPA
F
EGPED
-----------------
KLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YAN-PW
L
QE----
V
QTQK
L
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VAMQ
A
GAW
WQPD--AQG
--
I
D
RG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|444451.5.peg.1254
Escherichia coli O157:H7 str. EC4196 (15-792/793)
V
SRR
S
F
LQ
A
T
-
--
--
--
-
-
-
SALIT
LPF
ISSTAKAQSPD
A
S
PE
VTAPVAD
K
VV
----
P
T
-
C
STFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
TQITTLP
D
N
E
LDPQ
M
-
-
-
PI
M
R
A
C
VR
G
RGYRKF
VY
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVHVG
T
A
--------------
VS
G
GTF
S
-----GDAMAR
R
L
L
N
LT
GG
YLEYY
H
S
V
S
L
--
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
------
G
H
TN
Y
YF
Q
-KM
K
Q-
N
G
T
-
RF
I
V
V
DP
R
Y
SD
T
VS
--
S
LA
D
-
Q
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
-------------
DENSMPEGVPANES
LV
AY
L
F
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LAR
D
Y
A
TTK
P
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
D
------------------
M
P
ENPVQ
A
K
I
SIMNWMQ
A
ADD
A
SK
V
T
P
-Q
-----
DG
L
---------
K
G
V
DKLDSN
I
R
LL
F
SL
A
G
N
YLA
-----------------------
N
Q
N
PDV
H
QAA
K
L
L
EDES
K
I
-
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETW
G
T
AS--YLILS
EK
P
IEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
LG
-
-VE
A
E
F
SQ
----------
GR
DEKQ
W
I
-------------------------------
E
H
IW
--
E
QTRLAMPDEN
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
F
DM
-
-
----
-QDPE
I
P
A
L
S
H
Y
VPA
F
EGPED
-----------------
KLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YAN-PW
L
QE----
V
QTQK
L
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VAMQ
A
GAW
WQPD--AQG
--
I
D
RG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|444447.5.peg.767
Escherichia coli O157:H7 str. EC4206 (15-792/793)
V
SRR
S
F
LQ
A
T
-
--
--
--
-
-
-
SALIT
LPF
ISSTAKAQSPD
A
S
PE
VTAPVAD
K
VV
----
P
T
-
C
STFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
TQITTLP
D
N
E
LDPQ
M
-
-
-
PI
M
R
A
C
VR
G
RGYRKF
VY
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVHVG
T
A
--------------
VS
G
GTF
S
-----GDAMAR
R
L
L
N
LT
GG
YLEYY
H
S
V
S
L
--
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
------
G
H
TN
Y
YF
Q
-KM
K
Q-
N
G
T
-
RF
I
V
V
DP
R
Y
SD
T
VS
--
S
LA
D
-
Q
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
-------------
DENSMPEGVPANES
LV
AY
L
F
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LAR
D
Y
A
TTK
P
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
D
------------------
M
P
ENPVQ
A
K
I
SIMNWMQ
A
ADD
A
SK
V
T
P
-Q
-----
DG
L
---------
K
G
V
DKLDSN
I
R
LL
F
SL
A
G
N
YLA
-----------------------
N
Q
N
PDV
H
QAA
K
L
L
EDES
K
I
-
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETW
G
T
AS--YLILS
EK
P
IEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
LG
-
-VE
A
E
F
SQ
----------
GR
DEKQ
W
I
-------------------------------
E
H
IW
--
E
QTRLAMPDEN
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
F
DM
-
-
----
-QDPE
I
P
A
L
S
H
Y
VPA
F
EGPED
-----------------
KLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YAN-PW
L
QE----
V
QTQK
L
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VAMQ
A
GAW
WQPD--AQG
--
I
D
RG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|478004.5.peg.3027
Escherichia coli O157:H7 str. EC4401 (15-792/793)
V
SRR
S
F
LQ
A
T
-
--
--
--
-
-
-
SALIT
LPF
ISSTAKAQSPD
A
S
PE
VTAPVAD
K
VV
----
P
T
-
C
STFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
TQITTLP
D
N
E
LDPQ
M
-
-
-
PI
M
R
A
C
VR
G
RGYRKF
VY
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVHVG
T
A
--------------
VS
G
GTF
S
-----GDAMAR
R
L
L
N
LT
GG
YLEYY
H
S
V
S
L
--
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
------
G
H
TN
Y
YF
Q
-KM
K
Q-
N
G
T
-
RF
I
V
V
DP
R
Y
SD
T
VS
--
S
LA
D
-
Q
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
-------------
DENSMPEGVPANES
LV
AY
L
F
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LAR
D
Y
A
TTK
P
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
D
------------------
M
P
ENPVQ
A
K
I
SIMNWMQ
A
ADD
A
SK
V
T
P
-Q
-----
DG
L
---------
K
G
V
DKLDSN
I
R
LL
F
SL
A
G
N
YLA
-----------------------
N
Q
N
PDV
H
QAA
K
L
L
EDES
K
I
-
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETW
G
T
AS--YLILS
EK
P
IEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
LG
-
-VE
A
E
F
SQ
----------
GR
DEKQ
W
I
-------------------------------
E
H
IW
--
E
QTRLAMPDEN
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
F
DM
-
-
----
-QDPE
I
P
A
L
S
H
Y
VPA
F
EGPED
-----------------
KLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YAN-PW
L
QE----
V
QTQK
L
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VAMQ
A
GAW
WQPD--AQG
--
I
D
RG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|478005.5.peg.2597
Escherichia coli O157:H7 str. EC4486 (15-792/793)
V
SRR
S
F
LQ
A
T
-
--
--
--
-
-
-
SALIT
LPF
ISSTAKAQSPD
A
S
PE
VTAPVAD
K
VV
----
P
T
-
C
STFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
TQITTLP
D
N
E
LDPQ
M
-
-
-
PI
M
R
A
C
VR
G
RGYRKF
VY
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVHVG
T
A
--------------
VS
G
GTF
S
-----GDAMAR
R
L
L
N
LT
GG
YLEYY
H
S
V
S
L
--
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
------
G
H
TN
Y
YF
Q
-KM
K
Q-
N
G
T
-
RF
I
V
V
DP
R
Y
SD
T
VS
--
S
LA
D
-
Q
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
-------------
DENSMPEGVPANES
LV
AY
L
F
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LAR
D
Y
A
TTK
P
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
D
------------------
M
P
ENPVQ
A
K
I
SIMNWMQ
A
ADD
A
SK
V
T
P
-Q
-----
DG
L
---------
K
G
V
DKLDSN
I
R
LL
F
SL
A
G
N
YLA
-----------------------
N
Q
N
PDV
H
QAA
K
L
L
EDES
K
I
-
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETW
G
T
AS--YLILS
EK
P
IEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
LG
-
-VE
A
E
F
SQ
----------
GR
DEKQ
W
I
-------------------------------
E
H
IW
--
E
QTRLAMPDEN
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
F
DM
-
-
----
-QDPE
I
P
A
L
S
H
Y
VPA
F
EGPED
-----------------
KLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YAN-PW
L
QE----
V
QTQK
L
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VAMQ
A
GAW
WQPD--AQG
--
I
D
RG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|478006.5.peg.1636
Escherichia coli O157:H7 str. EC4501 (15-792/793)
V
SRR
S
F
LQ
A
T
-
--
--
--
-
-
-
SALIT
LPF
ISSTAKAQSPD
A
S
PE
VTAPVAD
K
VV
----
P
T
-
C
STFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
TQITTLP
D
N
E
LDPQ
M
-
-
-
PI
M
R
A
C
VR
G
RGYRKF
VY
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVHVG
T
A
--------------
VS
G
GTF
S
-----GDAMAR
R
L
L
N
LT
GG
YLEYY
H
S
V
S
L
--
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
------
G
H
TN
Y
YF
Q
-KM
K
Q-
N
G
T
-
RF
I
V
V
DP
R
Y
SD
T
VS
--
S
LA
D
-
Q
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
-------------
DENSMPEGVPANES
LV
AY
L
F
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LAR
D
Y
A
TTK
P
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
D
------------------
M
P
ENPVQ
A
K
I
SIMNWMQ
A
ADD
A
SK
V
T
P
-Q
-----
DG
L
---------
K
G
V
DKLDSN
I
R
LL
F
SL
A
G
N
YLA
-----------------------
N
Q
N
PDV
H
QAA
K
L
L
EDES
K
I
-
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETW
G
T
AS--YLILS
EK
P
IEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
LG
-
-VE
A
E
F
SQ
----------
GR
DEKQ
W
I
-------------------------------
E
H
IW
--
E
QTRLAMPDEN
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
F
DM
-
-
----
-QDPE
I
P
A
L
S
H
Y
VPA
F
EGPED
-----------------
KLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YAN-PW
L
QE----
V
QTQK
L
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VAMQ
A
GAW
WQPD--AQG
--
I
D
RG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|478007.5.peg.1680
Escherichia coli O157:H7 str. EC508 (15-792/793)
V
SRR
S
F
LQ
A
T
-
--
--
--
-
-
-
SALIT
LPF
ISSTAKAQSPD
A
S
PE
VTAPVAD
K
VV
----
P
T
-
C
STFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
TQITTLP
D
N
E
LDPQ
M
-
-
-
PI
M
R
A
C
VR
G
RGYRKF
VY
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVHVG
T
A
--------------
VS
G
GTF
S
-----GDAMAR
R
L
L
N
LT
GG
YLEYY
H
S
V
S
L
--
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
------
G
H
TN
Y
YF
Q
-KM
K
Q-
N
G
T
-
RF
I
V
V
DP
R
Y
SD
T
VS
--
S
LA
D
-
Q
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
-------------
DENSMPEGVPANES
LV
AY
L
F
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LAR
D
Y
A
TTK
P
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
D
------------------
M
P
ENPVQ
A
K
I
SIMNWMQ
A
ADD
A
SK
V
T
P
-Q
-----
DG
L
---------
K
G
V
DKLDSN
I
R
LL
F
SL
A
G
N
YLA
-----------------------
N
Q
N
PDV
H
QAA
K
L
L
EDES
K
I
-
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETW
G
T
AS--YLILS
EK
P
IEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
LG
-
-VE
A
E
F
SQ
----------
GR
DEKQ
W
I
-------------------------------
E
H
IW
--
E
QTRLAMPDEN
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
F
DM
-
-
----
-QDPE
I
P
A
L
S
H
Y
VPA
F
EGPED
-----------------
KLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YAN-PW
L
QE----
V
QTQK
L
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VAMQ
A
GAW
WQPD--AQG
--
I
D
RG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|386585.9.peg.3535
Escherichia coli O157:H7 str. Sakai (15-792/793)
V
SRR
S
F
LQ
A
T
-
--
--
--
-
-
-
SALIT
LPF
ISSTAKAQSPD
A
S
PE
VTAPVAD
K
VV
----
P
T
-
C
STFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
TQITTLP
D
N
E
LDPQ
M
-
-
-
PI
M
R
A
C
VR
G
RGYRKF
VY
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVHVG
T
A
--------------
VS
G
GTF
S
-----GDAMAR
R
L
L
N
LT
GG
YLEYY
H
S
V
S
L
--
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
------
G
H
TN
Y
YF
Q
-KM
K
Q-
N
G
T
-
RF
I
V
V
DP
R
Y
SD
T
VS
--
S
LA
D
-
Q
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
-------------
DENSMPEGVPANES
LV
AY
L
F
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LAR
D
Y
A
TTK
P
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
D
------------------
M
P
ENPVQ
A
K
I
SIMNWMQ
A
ADD
A
SK
V
T
P
-Q
-----
DG
L
---------
K
G
V
DKLDSN
I
R
LL
F
SL
A
G
N
YLA
-----------------------
N
Q
N
PDV
H
QAA
K
L
L
EDES
K
I
-
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETW
G
T
AS--YLILS
EK
P
IEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
LG
-
-VE
A
E
F
SQ
----------
GR
DEKQ
W
I
-------------------------------
E
H
IW
--
E
QTRLAMPDEN
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
F
DM
-
-
----
-QDPE
I
P
A
L
S
H
Y
VPA
F
EGPED
-----------------
KLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YAN-PW
L
QE----
V
QTQK
L
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VAMQ
A
GAW
WQPD--AQG
--
I
D
RG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|544404.4.peg.3518
Escherichia coli O157:H7 str. TW14359 (15-792/793)
V
SRR
S
F
LQ
A
T
-
--
--
--
-
-
-
SALIT
LPF
ISSTAKAQSPD
A
S
PE
VTAPVAD
K
VV
----
P
T
-
C
STFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
TQITTLP
D
N
E
LDPQ
M
-
-
-
PI
M
R
A
C
VR
G
RGYRKF
VY
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVHVG
T
A
--------------
VS
G
GTF
S
-----GDAMAR
R
L
L
N
LT
GG
YLEYY
H
S
V
S
L
--
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
------
G
H
TN
Y
YF
Q
-KM
K
Q-
N
G
T
-
RF
I
V
V
DP
R
Y
SD
T
VS
--
S
LA
D
-
Q
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
-------------
DENSMPEGVPANES
LV
AY
L
F
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LAR
D
Y
A
TTK
P
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
D
------------------
M
P
ENPVQ
A
K
I
SIMNWMQ
A
ADD
A
SK
V
T
P
-Q
-----
DG
L
---------
K
G
V
DKLDSN
I
R
LL
F
SL
A
G
N
YLA
-----------------------
N
Q
N
PDV
H
QAA
K
L
L
EDES
K
I
-
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETW
G
T
AS--YLILS
EK
P
IEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
LG
-
-VE
A
E
F
SQ
----------
GR
DEKQ
W
I
-------------------------------
E
H
IW
--
E
QTRLAMPDEN
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
F
DM
-
-
----
-QDPE
I
P
A
L
S
H
Y
VPA
F
EGPED
-----------------
KLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YAN-PW
L
QE----
V
QTQK
L
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VAMQ
A
GAW
WQPD--AQG
--
I
D
RG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|502346.5.peg.3897
Escherichia coli O157:H7 str. TW14588 (15-792/793)
V
SRR
S
F
LQ
A
T
-
--
--
--
-
-
-
SALIT
LPF
ISSTAKAQSPD
A
S
PE
VTAPVAD
K
VV
----
P
T
-
C
STFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
TQITTLP
D
N
E
LDPQ
M
-
-
-
PI
M
R
A
C
VR
G
RGYRKF
VY
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVHVG
T
A
--------------
VS
G
GTF
S
-----GDAMAR
R
L
L
N
LT
GG
YLEYY
H
S
V
S
L
--
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
------
G
H
TN
Y
YF
Q
-KM
K
Q-
N
G
T
-
RF
I
V
V
DP
R
Y
SD
T
VS
--
S
LA
D
-
Q
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
-------------
DENSMPEGVPANES
LV
AY
L
F
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LAR
D
Y
A
TTK
P
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
D
------------------
M
P
ENPVQ
A
K
I
SIMNWMQ
A
ADD
A
SK
V
T
P
-Q
-----
DG
L
---------
K
G
V
DKLDSN
I
R
LL
F
SL
A
G
N
YLA
-----------------------
N
Q
N
PDV
H
QAA
K
L
L
EDES
K
I
-
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETW
G
T
AS--YLILS
EK
P
IEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
LG
-
-VE
A
E
F
SQ
----------
GR
DEKQ
W
I
-------------------------------
E
H
IW
--
E
QTRLAMPDEN
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
F
DM
-
-
----
-QDPE
I
P
A
L
S
H
Y
VPA
F
EGPED
-----------------
KLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YAN-PW
L
QE----
V
QTQK
L
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VAMQ
A
GAW
WQPD--AQG
--
I
D
RG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|562.372.peg.1935
Escherichia coli 1212A (15-792/793)
V
SRR
S
F
LQ
A
T
-
--
--
--
-
-
-
SALIT
LPF
ISSTAKAQSPD
A
S
PE
VTAPVAD
K
VV
----
P
T
-
C
STFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
TQITTLP
D
N
E
LDPQ
M
-
-
-
PI
M
R
A
C
VR
G
RGYRKF
VY
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVHVG
T
A
--------------
VS
G
GTF
S
-----GDAMAR
R
L
L
N
LT
GG
YLEYY
H
S
V
S
L
--
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
------
G
H
TN
Y
YF
Q
-KM
K
Q-
N
G
T
-
RF
I
V
V
DP
R
Y
SD
T
VS
--
S
LA
D
-
Q
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
-------------
DENSMPEGVPANES
LV
AY
L
F
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LAR
D
Y
A
TTK
P
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
D
------------------
M
P
ENPVQ
A
K
I
SIMNWMQ
A
ADD
A
SK
V
T
P
-Q
-----
DG
L
---------
K
G
V
DKLDSN
I
R
LL
F
SL
A
G
N
YLA
-----------------------
N
Q
N
PDV
H
QAA
K
L
L
EDES
K
I
-
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETW
G
T
AS--YLILS
EK
P
IEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
LG
-
-VE
A
E
F
SQ
----------
GR
DEKQ
W
I
-------------------------------
E
H
IW
--
E
QTRLAMPDEN
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
F
DM
-
-
----
-QDPE
I
P
A
L
S
H
Y
VPA
F
EGPED
-----------------
KLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YAN-PW
L
QE----
V
QTQK
L
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
I
P
R
II
PGV
VAMQ
A
GAW
WQPD--AQG
--
I
D
RG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|562.374.peg.3138
Escherichia coli 536A (15-792/793)
V
SRR
S
F
LQ
A
T
-
--
--
--
-
-
-
SALIT
LPF
ISSTAKAQSPD
A
S
PE
VTAPVAD
K
VV
----
P
T
-
C
STFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
TQITTLP
D
N
E
LDPQ
M
-
-
-
PI
M
R
A
C
VR
G
RGYRKF
VY
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVHVG
T
A
--------------
VS
G
GTF
S
-----GDAMAR
R
L
L
N
LT
GG
YLEYY
H
S
V
S
L
--
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
------
G
H
TN
Y
YF
Q
-KM
K
Q-
N
G
T
-
RF
I
V
V
DP
R
Y
SD
T
VS
--
S
LA
D
-
Q
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
-------------
DENSMPEGVPANES
LV
AY
L
F
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LAR
D
Y
A
TTK
P
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
D
------------------
M
P
ENPVQ
A
K
I
SIMNWMQ
A
ADD
A
SK
V
T
P
-Q
-----
DG
L
---------
K
G
V
DKLDSN
I
R
LL
F
SL
A
G
N
YLA
-----------------------
N
Q
N
PDV
H
QAA
K
L
L
EDES
K
I
-
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETW
G
T
AS--YLILS
EK
P
IEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
LG
-
-VE
A
E
F
SQ
----------
GR
DEKQ
W
I
-------------------------------
E
H
IW
--
E
QTRLAMPDEN
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
F
DM
-
-
----
-QDPE
I
P
A
L
S
H
Y
VPA
F
EGPED
-----------------
KLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YAN-PW
L
QE----
V
QTQK
L
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
I
P
R
II
PGV
VAMQ
A
GAW
WQPD--AQG
--
I
D
RG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|155864.8.peg.3293
Escherichia coli O157:H7 EDL933 (15-792/793)
V
SRR
S
F
LQ
A
T
-
--
--
--
-
-
-
SALIT
LPF
ISSTAKAQSPD
A
S
PE
VTAPVAD
K
VV
----
P
T
-
C
STFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
TQITTLP
D
N
E
LDPQ
M
-
-
-
PI
M
R
A
C
VR
G
RGYRKF
VY
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVHVG
T
A
--------------
VX
G
GTF
S
-----GDAMAR
R
L
L
N
LT
GG
YLEYY
H
S
V
S
L
--
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
------
G
H
TN
Y
YF
Q
-KM
K
Q-
N
G
T
-
RF
I
V
V
DP
R
Y
SD
T
VS
--
S
LA
D
-
Q
WI
XLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
-------------
DENSMPEGVPANES
LV
AY
L
F
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LAR
D
Y
A
TTK
P
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
D
------------------
M
P
ENPVQ
A
K
I
SIMNWMQ
A
ADD
A
SK
V
T
P
-Q
-----
DG
L
---------
K
G
V
DKLDSN
I
R
LL
F
SL
A
G
N
YLA
-----------------------
N
Q
N
PDV
H
QAA
K
L
L
EDES
K
I
-
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETW
G
T
AS--YLILS
EK
P
IEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
LG
-
-VE
A
E
F
SQ
----------
GR
DEKQ
W
I
-------------------------------
E
H
IW
--
E
QTRLAMPDEN
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
F
DM
-
-
----
-QDPE
I
P
A
L
S
H
Y
VPA
F
EGPED
-----------------
KLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YAN-PW
L
QE----
V
QTQK
L
W
L
NP
Q
DA
KQ
RGI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VAMQ
A
GAW
WQPD--AQG
--
I
D
RG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|701177.3.peg.3080
Escherichia coli O55:H7 str. CB9615 (15-792/793)
V
SRR
S
F
LQ
A
T
-
--
--
--
-
-
-
SALIT
LPF
ISSTAKAQSPD
A
S
PE
VTAPVAD
K
VV
----
P
T
-
C
STFD
CG
GK
C
D
I
R
A
H
M
R
D
GV
V
TQITTLP
D
N
E
LDPQ
M
-
-
-
PI
M
R
A
C
VR
G
RGYRKF
VY
HP
DRL
KY
PM
K
R
VG
-----------
K
RG
----
EG
K
F
ER
ISWDEA
T
T
L
I
ADNLKRIT
Q
QY
G
P
A
S
R
YVHVG
T
A
--------------
VS
G
GTF
S
-----GDAMAR
R
L
L
N
LT
GG
YLEYY
H
S
V
S
L
--
G
N
T
AAATPYTY
G
VAASGNSMD
T
----
L
L
DT
KL
V
I
L
W
G
H
NP
T
ET
IF
-
-
------
G
H
TN
Y
YF
Q
-KM
K
Q-
N
G
T
-
RF
I
V
V
DP
R
Y
SD
T
VS
--
S
LA
D
-
Q
WI
PLL
P
T
TD
N
AL
MDA
M
M
YV
I
I
SE
N
LH
D
K
T
F
I
D
T
Y
T
--------
L
G
F
-------------
DENSMPEGVPANES
LV
AY
L
F
G
-
A
K
D
GIH
KT
PE
WA
E
K
IT
H
VP
AQ
S
I
R
Q
LAR
D
Y
A
TTK
P
AA
L
IQ
GW
--
G
P
QRH
IC
GE
RT
---
ARG
S
TL
L
AS
I
TG
N
VG
IK
G
-
G
---
WA
A
-----GYGGSSNRKFCVG
P
D
------------------
M
P
ENPVQ
A
K
I
SIMNWMQ
A
ADD
A
SK
V
T
P
-Q
-----
D
R
L
---------
K
G
V
DKLDSN
I
R
LL
F
SL
A
G
N
YLA
-----------------------
N
Q
N
PDV
H
QAA
K
L
L
EDES
K
I
-
E
F
IV
L
S
D
L
F
M
T
P
SAK
Y
AD
V
LLP
ET
S
FM
E
R
W
N
I--GETW
G
T
AS--YLILS
EKL
IEPD
FE
R
R
T
D
YDWLR
D
V
AK
K
LG
-
-VE
A
E
F
SQ
----------
GR
DEKQ
W
I
-------------------------------
E
H
IW
--
E
QTRLAMPDEN
LP
D
F
A
TLQKT
R
R
H
L
-FK----S
A
PH
I
A
F
--
EA
NI
R
DP
QN
N
-----
P
F
-
P
TPSGKIEI
F
S
KR
L
F
DM
-
-
----
-QDPE
I
P
A
L
S
H
Y
VPA
F
EGPED
-----------------
KLTAKYP
L
----
QL
I
T
W
K
GKN
R
A
N
S
T
Q
YAN-PW
L
QE----
V
QTQK
L
W
L
NP
Q
DA
KQ
S
GI
SE
GD
S
V
KI
Y
N
D
RG
VS
IIP
V
E
I
T
P
R
II
PGV
VAMQ
A
GAW
WQPD--AQG
--
I
D
RG
G
CA
N
V
L
S
STR
I
T
A
-
LAK
GNSHQTM
LV
E
V
EK
fig|656444.3.peg.2806
Escherichia coli TA280 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
S
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
QV
VAAQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
GR
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKG
S
A
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|585397.7.peg.2169
Escherichia coli ED1a (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQP
V
K
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
ID
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
VQ
G
KH
D
K
A
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAA
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|585397.9.peg.2165
Escherichia coli ED1a (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQP
V
K
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
ID
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
VQ
G
KH
D
K
A
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAA
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|199310.1.peg.2221
Escherichia coli CFT073 (4-797/815)
E
E
VM
T
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
T
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQP
V
K
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVLM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
I
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
RT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|1040638.4.peg.3965
Escherichia coli O104:H4 str. LB226692 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSST
V
E
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
TE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|6666666.5357.peg.325
Escherichia coli TY-2482 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSST
V
E
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
TE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|585055.6.peg.2081
Escherichia coli 55989 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSST
V
E
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
TE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|585055.8.peg.2084
Escherichia coli 55989 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSST
V
E
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
TE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|358709.5.peg.3773
Escherichia coli 101-1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
YEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
QV
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|199310.4.peg.2144
Escherichia coli CFT073 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
T
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQP
V
K
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVLM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
I
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
RT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|749528.3.peg.4972
Escherichia coli MS 45-1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
T
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQP
V
K
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVLM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
I
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
RT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|550676.3.peg.2194
Escherichia coli B185 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|701177.3.peg.2329
Escherichia coli O55:H7 str. CB9615 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAQ-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|656443.3.peg.2562
Escherichia coli TA271 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
S
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KI
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|585057.4.peg.1235
Escherichia coli IAI39 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
A
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
N
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEE
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKG
S
A
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|585057.6.peg.1234
Escherichia coli IAI39 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
A
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
N
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEE
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKG
S
A
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|656419.3.peg.2603
Escherichia coli M718 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
Q
S
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
N
V
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|216593.1.peg.707
Escherichia coli E2348/69 (4-797/815)
E
E
VM
T
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
T
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KARQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAAQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
I
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
RT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPT
R
LAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|340186.3.peg.3088
Escherichia coli E110019 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
T
R
I
QH
PM
V
R
KS
YL
-
DNPLQP
T
K
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|340186.5.peg.3218
Escherichia coli E110019 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
T
R
I
QH
PM
V
R
KS
YL
-
DNPLQP
T
K
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|155864.1.peg.2617
Escherichia coli O157:H7 EDL933 (4-797/815)
E
E
VM
T
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-Y
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAQ-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|656393.3.peg.2679
Escherichia coli H299 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
C
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKG
S
A
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|670888.3.peg.391
Escherichia coli 1827-70 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|481805.3.peg.1897
Escherichia coli ATCC 8739 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|481805.6.peg.1891
Escherichia coli ATCC 8739 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|413997.3.peg.1930
Escherichia coli B str. REL606 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|469008.4.peg.1820
Escherichia coli BL21(DE3) (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|331112.3.peg.1852
Escherichia coli HS (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|331112.6.peg.1927
Escherichia coli HS (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|679206.4.peg.2130
Escherichia coli MS 119-7 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|331111.12.peg.2381
Escherichia coli E24377A (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
S
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
ID
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IT
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
VFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|331111.3.peg.4520
Escherichia coli E24377A (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
S
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
ID
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IT
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
VFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|525281.3.peg.622
Escherichia coli 83972 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
T
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQP
V
K
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
I
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
RT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAP
E
EWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|655817.3.peg.2233
Escherichia coli ABU 83972 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
T
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQP
V
K
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
I
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
RT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAP
E
EWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|685038.3.peg.1892
Escherichia coli O83:H1 str. NRG 857C (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
T
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQP
V
K
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
C
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAAQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
I
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|439855.10.peg.1471
Escherichia coli SMS-3-5 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
I
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
VQ
G
KH
D
K
A
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
I
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLESG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|562.371.peg.4749
Escherichia coli 1044A (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-Y
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAQ-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|562.372.peg.4979
Escherichia coli 1212A (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-Y
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAQ-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|562.374.peg.4131
Escherichia coli 536A (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-Y
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAQ-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|83334.1.peg.2609
Escherichia coli O157:H7 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-Y
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAQ-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|155864.8.peg.2480
Escherichia coli O157:H7 EDL933 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-Y
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAQ-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|444454.5.peg.1343
Escherichia coli O157:H7 str. EC4024 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-Y
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAQ-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|444449.5.peg.843
Escherichia coli O157:H7 str. EC4042 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-Y
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAQ-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|444448.5.peg.5131
Escherichia coli O157:H7 str. EC4045 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-Y
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAQ-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|444453.5.peg.4463
Escherichia coli O157:H7 str. EC4076 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-Y
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAQ-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|444452.5.peg.1019
Escherichia coli O157:H7 str. EC4113 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-Y
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAQ-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|444450.8.peg.2642
Escherichia coli O157:H7 str. EC4115 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-Y
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAQ-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|444451.5.peg.4077
Escherichia coli O157:H7 str. EC4196 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-Y
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAQ-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|444447.5.peg.4856
Escherichia coli O157:H7 str. EC4206 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-Y
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAQ-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|478004.5.peg.4518
Escherichia coli O157:H7 str. EC4401 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-Y
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAQ-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|478006.5.peg.2783
Escherichia coli O157:H7 str. EC4501 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-Y
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAQ-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|478007.5.peg.4494
Escherichia coli O157:H7 str. EC508 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-Y
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAQ-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|478008.5.peg.4786
Escherichia coli O157:H7 str. EC869 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-Y
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAQ-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|637388.3.peg.4708
Escherichia coli O157:H7 str. FRIK2000 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-Y
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAQ-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|570506.3.peg.4096
Escherichia coli O157:H7 str. FRIK966 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-Y
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAQ-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|386585.9.peg.2707
Escherichia coli O157:H7 str. Sakai (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-Y
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAQ-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|544404.4.peg.2505
Escherichia coli O157:H7 str. TW14359 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-Y
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAQ-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|502346.5.peg.4803
Escherichia coli O157:H7 str. TW14588 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-Y
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAQ-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|344601.3.peg.3663
Escherichia coli B171 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|344601.5.peg.3822
Escherichia coli B171 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|340185.3.peg.3839
Escherichia coli E22 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|340185.4.peg.4050
Escherichia coli E22 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|679204.3.peg.3144
Escherichia coli MS 145-7 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
YA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|749533.3.peg.2495
Escherichia coli MS 84-1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|585395.4.peg.2235
Escherichia coli O103:H2 str. 12009 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|573235.3.peg.2764
Escherichia coli O26:H11 str. 11368 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|670897.3.peg.2758
Escherichia coli 2362-75 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
T
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KARQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAAQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
I
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
RT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|595495.4.peg.3778
Escherichia coli KO11 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
T
R
I
QH
PM
V
R
KS
YL
-
DNPLQP
T
K
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
I
GY
-------------
PQ------------
FEE
Y
L
R
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
M
R
A
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
H
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|566546.3.peg.4106
Escherichia coli W (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
T
R
I
QH
PM
V
R
KS
YL
-
DNPLQP
T
K
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
I
GY
-------------
PQ------------
FEE
Y
L
R
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
M
R
A
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
H
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|566546.4.peg.2039
Escherichia coli W (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
T
R
I
QH
PM
V
R
KS
YL
-
DNPLQP
T
K
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
I
GY
-------------
PQ------------
FEE
Y
L
R
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
M
R
A
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
H
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|656408.3.peg.2047
Escherichia coli H591 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
S
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|562.376.peg.2230
Escherichia coli WV_060327 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
T
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQP
V
K
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
I
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
RT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
S
S
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|216592.1.peg.1434
Escherichia coli 042 (4-797/815)
E
E
VM
T
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
Y
F
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAAQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|340197.3.peg.3114
Escherichia coli F11 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
T
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQP
V
K
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
C
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAAQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DV
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
I
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
RT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
S
S
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|340197.5.peg.3254
Escherichia coli F11 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
T
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQP
V
K
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
C
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAAQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DV
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
I
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
RT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
S
S
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|749550.3.peg.1925
Escherichia coli MS 200-1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
T
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQP
V
K
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
C
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAAQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DV
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
I
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
RT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
S
S
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|749527.3.peg.811
Escherichia coli MS 21-1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
T
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQP
V
K
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
C
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAAQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DV
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
I
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
RT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
S
S
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|749547.3.peg.1206
Escherichia coli MS 187-1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
LF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|550677.3.peg.1363
Escherichia coli B354 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SATPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKG
S
A
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
K
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|656379.3.peg.2358
Escherichia coli FVEC1302 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEI
S
GVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAAQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|656380.3.peg.3321
Escherichia coli FVEC1412 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEI
S
GVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAAQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|749549.3.peg.3150
Escherichia coli MS 198-1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEI
S
GVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAAQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|585056.7.peg.2355
Escherichia coli UMN026 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEI
S
GVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAAQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|656417.3.peg.2475
Escherichia coli M605 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
T
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
N
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
I
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
RT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|749538.3.peg.4492
Escherichia coli MS 116-1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
D
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AV
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGHASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAI
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|749544.3.peg.2393
Escherichia coli MS 175-1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
D
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AV
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGHASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAI
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|431946.3.peg.1798
Escherichia coli SE15 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDHIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
N
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
I
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
RT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|216592.3.peg.2121
Escherichia coli 042 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
Y
F
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAAQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|585034.4.peg.1936
Escherichia coli IAI1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
VFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|585034.5.peg.1931
Escherichia coli IAI1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
VFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|714962.3.peg.2030
Escherichia coli IHE3034 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
T
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
C
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
I
TA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
I
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
RT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
LDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNTA
LV
Y
IEK
fig|753642.3.peg.2475
Escherichia coli NC101 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
T
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
C
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
I
TA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
I
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
RT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
LDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNTA
LV
Y
IEK
fig|585035.6.peg.1918
Escherichia coli S88 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
T
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
C
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
I
TA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
I
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
RT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
LDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNTA
LV
Y
IEK
fig|869729.3.peg.1653
Escherichia coli UM146 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
T
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
C
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
I
TA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
I
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
RT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
LDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNTA
LV
Y
IEK
fig|364106.7.peg.2109
Escherichia coli UTI89 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
T
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
C
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
I
TA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
I
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
RT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
LDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNTA
LV
Y
IEK
fig|364106.8.peg.2112
Escherichia coli UTI89 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
T
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
C
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
I
TA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
I
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
RT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
LDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNTA
LV
Y
IEK
fig|749531.3.peg.623
Escherichia coli MS 69-1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
E
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
V
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
I
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
VQ
G
KH
D
K
A
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
A
G
K
-
S
D
NTP
K
S
AA
WAAEI
S
GVP
EA
QI
I
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
GR
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKG
S
A
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
R
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|340184.3.peg.3183
Escherichia coli B7A (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
A
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
YA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|340184.6.peg.3322
Escherichia coli B7A (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
A
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
YA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|749537.3.peg.1303
Escherichia coli MS 115-1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
T
R
I
QH
PM
V
R
KS
YL
-
DNPLQP
T
K
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
ID
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
R
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
M
R
A
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|656437.3.peg.2122
Escherichia coli TA143 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
E
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
I
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
VQ
G
KH
D
K
A
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
A
G
K
-
S
D
NTP
K
S
AA
WAAEI
S
GVP
EA
QI
I
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAAQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
GR
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKG
S
A
DDKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|409438.11.peg.2261
Escherichia coli SE11 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
T
R
I
QH
PM
V
R
KS
YL
-
DNPLQP
T
K
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRSSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAG-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
TR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|595496.3.peg.1842
Escherichia coli BW2952 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
D
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AV
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGHASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRHSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAI
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|536056.3.peg.1870
Escherichia coli DH1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
D
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AV
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGHASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRHSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAI
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|83333.1.peg.1856
Escherichia coli K12 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
D
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AV
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGHASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRHSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAI
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|316407.3.peg.1828
Escherichia coli W3110 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
D
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AV
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGHASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRHSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAI
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|316385.7.peg.2040
Escherichia coli str. K-12 substr. DH10B (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
D
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AV
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGHASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRHSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAI
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|511145.12.peg.1952
Escherichia coli str. K-12 substr. MG1655 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
D
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AV
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGHASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRHSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAI
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|511145.6.peg.1936
Escherichia coli str. K-12 substr. MG1655 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
D
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AV
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGHASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRHSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAI
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|749545.3.peg.2995
Escherichia coli MS 182-1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
K
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
M
R
A
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWL
V
PDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAG-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|749532.3.peg.2439
Escherichia coli MS 78-1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
K
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
M
R
A
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWL
V
PDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAG-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|679207.4.peg.4773
Escherichia coli MS 107-1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
T
R
I
QH
PM
V
R
KS
YL
-
DNPLQP
T
K
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
ID
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
R
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
M
R
A
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
VFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAG-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|562.373.peg.5648
Escherichia coli 1125A (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHERIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-Y
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
W
T
AEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
E
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
C
L
HS
Q
-
LNYAQ-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|562.371.peg.990
Escherichia coli 1044A (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
HDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|562.371.peg.989
Escherichia coli 1044A (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
HDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|562.373.peg.754
Escherichia coli 1125A (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
HDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|562.373.peg.755
Escherichia coli 1125A (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
HDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|562.372.peg.4549
Escherichia coli 1212A (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
HDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|562.372.peg.4550
Escherichia coli 1212A (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
HDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|562.374.peg.1460
Escherichia coli 536A (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
HDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|562.374.peg.1459
Escherichia coli 536A (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
HDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|83334.1.peg.1211
Escherichia coli O157:H7 (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
HDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|444454.5.peg.5731
Escherichia coli O157:H7 str. EC4024 (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
HDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|444449.5.peg.4587
Escherichia coli O157:H7 str. EC4042 (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
HDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|444448.5.peg.3856
Escherichia coli O157:H7 str. EC4045 (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
HDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|444453.5.peg.2468
Escherichia coli O157:H7 str. EC4076 (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
HDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|444452.5.peg.526
Escherichia coli O157:H7 str. EC4113 (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
HDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|444450.8.peg.1315
Escherichia coli O157:H7 str. EC4115 (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
HDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|444451.5.peg.1365
Escherichia coli O157:H7 str. EC4196 (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
HDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|444447.5.peg.4080
Escherichia coli O157:H7 str. EC4206 (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
HDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|478004.5.peg.1153
Escherichia coli O157:H7 str. EC4401 (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
HDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|478006.5.peg.3642
Escherichia coli O157:H7 str. EC4501 (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
HDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|478007.5.peg.3303
Escherichia coli O157:H7 str. EC508 (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
HDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|478008.5.peg.2731
Escherichia coli O157:H7 str. EC869 (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
HDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|637388.3.peg.4242
Escherichia coli O157:H7 str. FRIK2000 (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
HDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|570506.3.peg.1590
Escherichia coli O157:H7 str. FRIK966 (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
HDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|386585.9.peg.1268
Escherichia coli O157:H7 str. Sakai (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
HDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|544404.4.peg.1179
Escherichia coli O157:H7 str. TW14359 (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
HDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|502346.5.peg.21
Escherichia coli O157:H7 str. TW14588 (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
HDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|585396.4.peg.2548
Escherichia coli O111:H- str. 11128 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMLHVV
G
SVEVYEQQT
SWPLIL
ENS
QA
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
G
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AA
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGQASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKN
E
QY
V
R
Y
--
AD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAV
A
DREP
I
T
I
HT
E
DA
AR
F
GI
AN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|749548.3.peg.4800
Escherichia coli MS 196-1 (3-791/809)
L
T
RR
E
F
I
K
H
S
G
--
I
A
AG
A
L
-
--VVT
---
---SAAPLPAW
A
E
--
---EKGG
K
IL
TAGR
W
G
-
A
----
--
--
-
-
M
N
V
E
V
K
D
GK
I
VSSTGAL
A
K
T
IPNS
L
-
-
-
----
-
-
--
Q
STAADQ
V
H
TT
A
R
I
QH
PM
V
R
KS
YL
-
DNPLQPAK
G
RG
----
E
D
T
Y
VQ
V
SW
EQ
A
L
K
L
I
HEQHDRIR
K
AN
G
PS
AI
F----
A
G
--------------
SY
G
WRS
S
GVLHKAQTLLQ
R
Y
MN
LA
GG
YSGHS
G
D
YS
T
--
G
A
A
QVIMPHVV
G
SVEVYEQQT
SWPLIL
ENS
QV
VVL
W
G
M
NP
L
N
T
LK
I
A
WSSTDE
Q
G
LE
Y
FH
Q
LK-
-
-K
S
G
K
-
PV
I
A
IDP
I
R
SE
T
IE
FF
D
-D
NA
T
WI
APN
M
GTD
V
AL
MLG
IA
HT
L
M
TQ
G
KH
D
K
V
FL
E
KY
T
--------
T
GY
-------------
PQ------------
FEE
Y
L
T
G
K
-
S
D
NTP
K
S
AV
WAAEITGVP
EA
QI
V
KLA
E
L
M
A
ANR
-
TM
L
MA
GW
--
G
I
QR
Q
QY
GE
QK
---
HWM
L
VT
L
AA
ML
G
Q
I
G
TP
G
-
G
---
GF
G
FSYHYSNGGNPTRVGGVL
P
E
------------------
M
-
----S
A
A
I
AGHASEA
A
DD-
-
GG
MTA
IP
VARIV
D
A
L
ENPGGKYQH
N
GK
EQTYPN
IK
MI
W
-W
A
G
G
GNF
-----------------------
T
H
H
QDT
N
R--
-
L
I
KAWQ
K
P
-
E
M
IV
V
SE
C
Y
W
T
A
A
AK
H
ADI
V
LP
IT
T
SF
E
R
N
D
L---TMT
G
D
YSNQHIVPM
K
Q
A
VAPQ
FE
A
R
N
D
FDVFA
D
L
A
E
L
L
K
P
GGK
E
I
Y
TE
----------
G
K
DEMA
WL
-------------------------------
K
F
F
Y
DA
A
QKGARAQRVT
M
P
M
F
N
AFWQQ
N
K
L
I
EMRRSEKS
E
QY
V
R
Y
--
GD
FR
A
DP
VK
N
-----
A
L
-
G
TPSGKIEIYS
KT
L
E
KF
-
-
----
-----
-
-
---
-
-
---
-
-GYKD
CPAHPTWLAPDEWKGTA
DEKQ---
L
----
QL
L
T
A
H
PAH
R
L
HS
Q
-
LNYAE-
L
RKKYAI
A
DREP
I
T
I
HT
E
DA
AR
F
GI
VN
GD
L
VRV
W
N
K
RG
Q
I
LTG
A
V
VT
D
G
IK
K
GV
VCVH
E
GAW
PDLENG---
--
L
C
KN
G
SA
N
V
LT
ADI
PS
SQ
LA
N
ACAGNSA
LV
Y
IEK
fig|701177.3.peg.1217
Escherichia coli O55:H7 str. CB9615 (1-817/848)
MN
N
N
D
LFQ
A
SRR
R
F
L
A
Q
L
G
GLTV
AG
M
L
G
PSLLT
---
---SRRATAAQ
A
A
TE
AVISKEG
-
IL
T
GSH
W
G
-
A
----
--
--
-
-
I
R
A
T
V
K
D
GR
F
VAAKPFE
L
D
K
YPSK
M
-
-
-
----
-
-
--
I
AGLPDH
V
H
NA
A
R
I
RY
PM
V
R
VD
W
L
RKRH
L
SDTS
Q
RG
----
D
N
R
F
VR
V
SWDEA
L
D
M
F
YEELERVQ
K
TH
G
PS
A
L
L----
T
A
--------------
S-
G
WQS
T
GMFHNASGMLA
K
A
I
A
LH
G
N
SVGTG
G
D
YS
T
--
G
A
A
QVILPRVV
G
SMEVYEQQT
SWPL
V
L
Q
NS
KT
I
VL
W
G
S
D
L
L
K
N
QQ
A
N
W
WCP
D
H
D
V
YE
Y
YA
Q
LKA
K
VA
A
G
E
I
EV
I
S
IDP
V
V
TS
T
HE
YL
G
RE
HV
K
H
I
AVN
P
Q
TD
V
P
L
QLA
L
A
HT
L
Y
SE
N
LY
D
K
N
FL
A
N
Y
C
--------
V
G
F
-------------
EQ------------
F
LP
Y
L
L
G
E
-
K
D
GQP
K
D
AA
WA
E
KL
TG
I
D
AE
T
I
R
G
LAR
Q
M
A
ANR
-
TQ
I
IA
GW
--
C
V
QR
M
QH
GE
QW
---
AWM
I
VV
L
AA
ML
G
Q
I
G
LP
G
-
G
---
GF
G
FGWHYNGAGTPGRKGVIL
S
G
------------------
F
-
----S
G
S
T
SIPPVHD
N
SDY
K
GY
S
S
T
IP
I
AR
FI
D
A
I
LE
PG
KVINW
N
GK
SVKLPP
L
K
MC
I
-F
A
G
T
NPF
-----------------------
H
R
H
QQI
N
R--
-
I
I
EGWR
K
L
-
E
T
V
I
A
ID
N
Q
W
T
S
T
C
R
F
ADI
V
LP
AT
T
QF
E
R
N
D
L---DQY
GN
HSNRGIIAM
K
QV
VPPQ
FE
A
R
N
D
FDIFR
E
L
C
R
R
F
N
-
-RE
E
A
FTE
----------
G
L
DEMG
WL
-------------------------------
K
R
IW
QE
G
VQQGKGRGVH
LP
A
FD
DFWNN
K
E
Y
V
EF---DHP
Q
MF
V
R
H
--
QA
FR
E
DP
DL
E
-----
P
L
-
G
TPSG
L
IEIYS
KT
I
A
DM
-
-
----
-----
-
-
---
-
-
---
-
-NYDD
C
QG
HP
M
W
FEKI
E
RSHGG
PGSQTYP
L
----
H
L
Q
S
V
H
PDF
R
L
HS
Q
-
LCESET
L
RQQYTV
A
GKEP
V
F
INP
Q
DA
SA
RGI
RN
GD
V
VRV
F
N
A
RG
Q
V
LAG
A
V
V
S
D
R
YA
PGV
ARIH
E
GAW
YDPDKGGEP
GA
L
C
KY
G
NP
N
V
LT
IDI
G
T
SQ
LA
Q
ATSAHTT
LV
E
IEK
fig|409438.11.peg.4899
Escherichia coli SE11 (1-757/758)
M
S
ISRR
S
F
LQ
G
M
G
--
IG
CS
A
C
A
LGVFS
---
-------PGTL
A
R
NP
VAGIKGK
T
TL
T
PTLC
E
-
M
CSF-
--
-R
C
P
V
Q
A
Q
V
V
N
NK
T
VFIQG--
-
-
-
--NP
SAS
H
QGT
R
V
C
AR
G
GSGVSL
V
N
DP
Q
R
I
VK
PM
K
R
TG
-----------
P
RG
----
S
G
E
W
QV
ISW
Q
Q
A
Y
Q
E
I
AAKMNAIK
A
QY
G
P
E
SV
VF---
S
S
--------------
KA
G
SLS
S
HLFHLATAF--
-
-
--
--
-
G
SPNTF
T
H
A
S
T
CP
A
G
K
AIAAKVMM
G
G--------
D
LAMD
I
A
N
T
RY
L
V
S
FG
H
N
L
Y
E
G
IE
V
A
------
-
-
--
D
TH
E
LMA
A
QE
K
G
A
-
RM
V
S
F
DP
R
L
SI
F
SS
--
-
KA
D
-
E
W
H
AIR
PG
G
D
L
A
V
LLA
M
C
HV
M
I
DE
Q
LY
D
A
D
F
V
E
R
Y
T
--------
T
G
F
-------------
EQLALAV-------
-----
-
-
-
-
K
D
A--
-
T
PE
WAA
TQAD
VP
AD
V
I
V
RV
T
RE
L
A
ACA
P
HA
I
VS
PG
--
-
-
H
R
S
TF
S
Q
EE
IDM
RRM
I
FT
L
NA
L
L
G
N
I
E
RK
G
-
G
LYQ
KK
G
AAVYNKLAGE-----KVA
P
T
------------------
L
-
-----
A
K
I
DVKNM--
-
---
-
PK
P
TA
QR
----
I
D
L
V
---------
-
--
---APQ
F
R
YI
-
-A
A
G
G
GVV
QSIIDAALTRKPYPIKAWIMSRH
N
P
F
QTV
T
CRP
D
L
V
KTVE
R
L
-
D
L
V
V
S
C
D
V
Y
L
S
E
SA
A
Y
AD
Y
LLP
EC
T
YL
E
R
D
E
DVT-DMS
G
L
HP--AYGLR
QQV
VEPV
G
E
A
R
P
S
WQIWK
E
L
G
QQ
LG
L
GQY
Y
P
W
Q
D
----------
M
Q
T---
--
-------------------------------
R
Q
LY
QL
N
GDHALAARLR
EK
G
Y
L
EWGVP
-
-
-
L
LLREAESV
Q
QF
T
A
RYP
NA
LA
A
D
S
DN
TY
GE
QL
R
F
-
K
S
PSGKIE
L
C
S
EV
L
E
GL
-
-
----
-----
-
-
---
-
-
---
L
PGYGV
-----------------
PRSRDFT
L
KRDD
E
L
Y
F
I
Q
GKV
A
V
H
T
N
-
-GATQY
V
PLLSEL
M
WDNA
V
W
I
H
P
Q
T
A
RE
K
GI
KT
GD
E
I
W
L
E
N
A
T
G
K
E
KGK
A
L
VT
P
G
IR
P
DT
LFVY
M
G
--
FGARAGAKT
AA
T
T
HG
I
HC
G
N
L
L
PHV
T
SP
-
-VS
GTVVHTA
G
V
T
L
S
R
fig|331111.12.peg.2791
Escherichia coli E24377A (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SDTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSK
Y
PVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|331111.3.peg.246
Escherichia coli E24377A (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SDTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSK
Y
PVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|656393.3.peg.3239
Escherichia coli H299 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSK
Y
PVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|656408.3.peg.2457
Escherichia coli H591 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSK
Y
PVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|679206.4.peg.2433
Escherichia coli MS 119-7 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSK
Y
PVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|585396.4.peg.3038
Escherichia coli O111:H- str. 11128 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSK
Y
PVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|573235.3.peg.3207
Escherichia coli O26:H11 str. 11368 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSK
Y
PVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|656443.3.peg.2917
Escherichia coli TA271 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSK
Y
PVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|753642.3.peg.2881
Escherichia coli NC101 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFP
L
SELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|562.376.peg.4130
Escherichia coli WV_060327 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|405955.13.peg.2427
Escherichia coli APEC O1 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|405955.9.peg.1980
Escherichia coli APEC O1 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|585397.7.peg.2674
Escherichia coli ED1a (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYD
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|585397.9.peg.2671
Escherichia coli ED1a (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYD
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|714962.3.peg.2487
Escherichia coli IHE3034 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|585035.6.peg.2333
Escherichia coli S88 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|869729.3.peg.1224
Escherichia coli UM146 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|364106.7.peg.2513
Escherichia coli UTI89 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|364106.8.peg.2514
Escherichia coli UTI89 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|585057.4.peg.2440
Escherichia coli IAI39 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
K
M
GEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|585057.6.peg.2443
Escherichia coli IAI39 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
K
M
GEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|413997.3.peg.2229
Escherichia coli B str. REL606 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
T
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|511693.5.peg.2241
Escherichia coli BL21 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
T
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|469008.4.peg.1494
Escherichia coli BL21(DE3) (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
T
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|701177.3.peg.2772
Escherichia coli O55:H7 str. CB9615 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
V
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|216592.1.peg.3014
Escherichia coli 042 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|216592.3.peg.2559
Escherichia coli 042 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|358709.5.peg.658
Escherichia coli 101-1 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|670888.3.peg.4074
Escherichia coli 1827-70 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|362663.8.peg.2267
Escherichia coli 536 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFP
L
SELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|362663.9.peg.2271
Escherichia coli 536 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFP
L
SELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|344610.3.peg.1688
Escherichia coli 53638 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|344610.7.peg.4193
Escherichia coli 53638 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|525281.3.peg.4014
Escherichia coli 83972 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|655817.3.peg.2656
Escherichia coli ABU 83972 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|481805.3.peg.1547
Escherichia coli ATCC 8739 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|481805.6.peg.1539
Escherichia coli ATCC 8739 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|550672.3.peg.1927
Escherichia coli B088 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|550677.3.peg.1754
Escherichia coli B354 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|340184.3.peg.400
Escherichia coli B7A (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|340184.6.peg.417
Escherichia coli B7A (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|199310.1.peg.2674
Escherichia coli CFT073 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|199310.4.peg.2585
Escherichia coli CFT073 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|340186.3.peg.1313
Escherichia coli E110019 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
Q
YDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAE
E
QLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|340186.5.peg.1362
Escherichia coli E110019 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
Q
YDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAE
E
QLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|340185.3.peg.640
Escherichia coli E22 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|340185.4.peg.683
Escherichia coli E22 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|340197.3.peg.268
Escherichia coli F11 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFP
L
SELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|340197.5.peg.278
Escherichia coli F11 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFP
L
SELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|656379.3.peg.2742
Escherichia coli FVEC1302 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|656380.3.peg.2301
Escherichia coli FVEC1412 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|331112.3.peg.2200
Escherichia coli HS (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|331112.6.peg.2300
Escherichia coli HS (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|679205.4.peg.5334
Escherichia coli MS 124-1 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|679204.3.peg.243
Escherichia coli MS 145-7 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|749546.3.peg.2990
Escherichia coli MS 185-1 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|585395.4.peg.2807
Escherichia coli O103:H2 str. 12009 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|685038.3.peg.2268
Escherichia coli O83:H1 str. NRG 857C (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFP
L
SELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|409438.11.peg.2632
Escherichia coli SE11 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|431946.3.peg.2180
Escherichia coli SE15 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|439855.10.peg.2521
Escherichia coli SMS-3-5 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFP
L
SELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|656440.3.peg.2193
Escherichia coli TA206 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYD
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|585056.7.peg.2724
Escherichia coli UMN026 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|656417.3.peg.2882
Escherichia coli M605 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAYRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|562.371.peg.5067
Escherichia coli 1044A (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|562.373.peg.3956
Escherichia coli 1125A (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|562.372.peg.5562
Escherichia coli 1212A (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|562.374.peg.3356
Escherichia coli 536A (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|550676.3.peg.2527
Escherichia coli B185 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|656419.3.peg.2966
Escherichia coli M718 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|83334.1.peg.3089
Escherichia coli O157:H7 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|444454.5.peg.2021
Escherichia coli O157:H7 str. EC4024 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|444448.5.peg.244
Escherichia coli O157:H7 str. EC4045 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|444453.5.peg.1590
Escherichia coli O157:H7 str. EC4076 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|444452.5.peg.2609
Escherichia coli O157:H7 str. EC4113 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|444450.8.peg.3334
Escherichia coli O157:H7 str. EC4115 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|444451.5.peg.792
Escherichia coli O157:H7 str. EC4196 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|444447.5.peg.378
Escherichia coli O157:H7 str. EC4206 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|478004.5.peg.1754
Escherichia coli O157:H7 str. EC4401 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|478005.5.peg.1871
Escherichia coli O157:H7 str. EC4486 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|478006.5.peg.4988
Escherichia coli O157:H7 str. EC4501 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|478007.5.peg.4994
Escherichia coli O157:H7 str. EC508 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|478008.5.peg.2367
Escherichia coli O157:H7 str. EC869 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|637388.3.peg.376
Escherichia coli O157:H7 str. FRIK2000 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|570506.3.peg.4956
Escherichia coli O157:H7 str. FRIK966 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|386585.9.peg.3229
Escherichia coli O157:H7 str. Sakai (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|544404.4.peg.3137
Escherichia coli O157:H7 str. TW14359 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|502346.5.peg.4285
Escherichia coli O157:H7 str. TW14588 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|670897.3.peg.3185
Escherichia coli 2362-75 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFP
L
SELAEDQLNDES
H
ELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|216593.1.peg.2536
Escherichia coli E2348/69 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFP
L
SELAEDQLNDES
H
ELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|574521.7.peg.2407
Escherichia coli O127:H6 str. E2348/69 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
S
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFP
L
SELAEDQLNDES
H
ELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|595496.3.peg.2177
Escherichia coli BW2952 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
D
LLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|536056.3.peg.1525
Escherichia coli DH1 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
D
LLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|656414.3.peg.2581
Escherichia coli H736 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
D
LLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|83333.1.peg.2180
Escherichia coli K12 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
D
LLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|316407.3.peg.2138
Escherichia coli W3110 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
D
LLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|316385.5.peg.2331
Escherichia coli str. K-12 substr. DH10B (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
D
LLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|316385.7.peg.2385
Escherichia coli str. K-12 substr. DH10B (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
D
LLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|511145.12.peg.2295
Escherichia coli str. K-12 substr. MG1655 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
D
LLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|511145.6.peg.2279
Escherichia coli str. K-12 substr. MG1655 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
D
LLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|1040638.4.peg.3289
Escherichia coli O104:H4 str. LB226692 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
GGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|6666666.5357.peg.553
Escherichia coli TY-2482 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
GGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|585055.6.peg.2495
Escherichia coli 55989 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
GGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|585055.8.peg.2501
Escherichia coli 55989 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
GGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|562.375.peg.3193
Escherichia coli EC4100B (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
GGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|585034.4.peg.2258
Escherichia coli IAI1 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
GGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|585034.5.peg.2255
Escherichia coli IAI1 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
GGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|595495.4.peg.227
Escherichia coli KO11 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
GGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|566546.3.peg.1426
Escherichia coli W (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
GGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|566546.4.peg.2388
Escherichia coli W (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
GGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|155864.1.peg.3094
Escherichia coli O157:H7 EDL933 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VXGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|155864.8.peg.2988
Escherichia coli O157:H7 EDL933 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VXGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
D
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|656444.3.peg.3201
Escherichia coli TA280 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
W
EQ
A
F
D
V
M
EDKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
D
LLAKKPELR
G
K
TLYE
V
L
YATPEVSK
Y
PVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|656437.3.peg.2479
Escherichia coli TA143 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
KP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
D
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFP
L
SELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|344601.3.peg.1443
Escherichia coli B171 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNDK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|344601.5.peg.1519
Escherichia coli B171 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
V
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
ELLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNDK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
fig|316401.4.peg.2678
Escherichia coli ETEC H10407 (3-828/828)
L
SRR
S
F
MK
A
N
A
--
V
A
AA
A
A
A
AGLSV
---
--------PGV
A
R
AV
VGQQEAI
K
--
----
W
D
K
A
PCRF
CG
TG
C
G
V
L
V
G
T
Q
Q
GR
M
VACQGDP
D
A
P
VNRG
L
-
-
-
----
N
C
IK
G
YFLPKI
M
Y
GK
DRL
TQ
P
L
L
R
M-
-----------
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKFKTAL
K
EK
G
P
E
S
I
GM-FG
S
G
QWTIWEGYAASKLF
KA
G
FRS
N
NIDPNARHCM-
-
-
--
--
--
-----
-
-
--
-
--
A
S
A
VVGFMRTF
G
MDEPMGCYD
D
----
IE
Q
A
DA
F
VL
W
G
A
N
M
A
E
M
HP
I
L
WS
----
-
-
--
-
--
R
ITN
R
RL
SN
Q
N
VT
V
A
VLS
T
Y
QH
R
SF
--
E
LA
D
-
N
G
I
IFT
P
QS
D
L
VI
LNY
IA
NY
I
I
QN
N
AI
N
Q
D
F
F
S
K
H
V
NLRKGATD
I
GY
GLRPTHPLEKAAK
NPGSDASEPMSFED
YKA
F
V
A
E
Y
-
-
-
---
-
T
LE
KT
AE
M
TGVP
KD
Q
L
E
Q
LA
Q
L
Y
A
DPN
-
KK
V
IS
Y
W
TM
G
F
NQ
H
TR
G
V
WA
---
NNL
V
YN
L
HL
LTG
K
IS
QP
G
C
G
PFS
LT
G
QPSACGTAREVGTFAHRL
P
A
DMVVTNEKHRDICEKKWN
I
P
SGTIP
A
K
I
GLHAV--
-
---
-
AQ
DR
A
LK
-----
DG
K
---------
-
--
------
LN
VY
W
TM
C
T
N
---
-----------------------
N
M
Q
AGP
N
INE
E
R
M
PGWR
DPRN
F
I
I
V
S
D
P
Y
P
T
V
SA
L
A
AD
L
I
LP
TA
M
WV
E
K
E
-
----GAY
GN
AERRTQFWR
QQV
QAPG
-
E
A
K
S
D
LWQLV
Q
F
S
R
R
FK
-
-TE
E
V
W
P
E
D
LLAKKPELR
G
K
TLYE
V
L
YATPEVSKFPVSELAEDQLNDESRELGFYLQ
K
G
L
F
EE
Y
AWFGRGHGHD
L
A
P
FD
DYHKA
-
R
G
L
RWPVVNGK
E
TQ
WR
Y
--
-S
EG
N
DP
YV
KAGEGY
K
FY
G
K
P
D
GK
AV
I
FA
LP
FE
PA
A
E
----
-----
-
-
---
-
-
---
-
-----
-----------------
APDEEYD
L
----
W
L
S
T
G
R
VLE
H
W
H
T
G
-
-SMTRR
V
PELHRA
F
PEAV
L
F
I
H
P
L
DA
KA
R
DL
RR
GD
K
V
K
V
V
S
R
RGEV
ISI
V
E
TR
G
R
NR
P
P
-
----
QG
LV
YMPF-----
--
F
D
AA
Q
LV
N
K
LT
LDA
TD
P
-
L
S
K
ETDFKKC
A
V
K
L
EKV
Consen1
Primary consensus
MskNe
mvgisRR
lmK
sa
--
ig
a
a
lpf
-
--
K
----
W
-
a
cg
c
l
l
v
d
v
d
t
y
-
g
hqvr
c
g
vy
dRl
Pm
R
-----------
rG
----
Eg
f
isWdeA
d
i
k
Gneai
tG
--------------
G
t
r
mn
gg
g
ys
--
a
i
G
d
----
iens
vVlfG
Np
et
s
------
g
y
e
r
Sn
-
i
idp
y
t
--
g
d
-
wi
pgtD
al
iA
li
n
dq
Fl
Ky
--------
GY
-------------
ykayi
g
g
d
kt
waaeiTgvP
qi
kLAre
g
p
i
gW
--
G
qrh
Ge
---
i
L
ltG
vg
G
-
G
---
G
P
------------------
l
-
t
I
a
g
mtA
-----
Dg
---------
gk
ik
W
a
n
-----------------------
n
h
N
e
l
kc
-
e
Iv
id
f
T
sAk
aDilLP
m
Eq
d
Gn
qqv
fE
k
i
e
akrlgp
q
ftE
----------
Gr
wl
-------------------------------
k
ly
a
lp
fd
-
gi
e
vay
--
fr
DP
n
-----
l
-
tPsGKieIys
la
a
twel
i
plp
y
f
-----------------
L
----
qL
g
h
r
Hs
-
l
a
v
Inp
DA
rgi
GD
Vrv
n
rGev
a
vt
r
pgv
qGaw
--
d
g
N
LT
psp
-
Lak
lV
iEKv
Consen2
Secondary consensus
mn
lfq
t
f
g
a
m
-
---
a
av
tagr
ks
--
-
t
q
i
a
p
ld
-
----
-
q
a
i
l
yl
dnplqpak
n
kydk
d
y
vt
eq
k
m
e
pssv
qwtiwegyaasklf
-
--
--
-
--
g
a
swplilaq
f
mw
m
nm
i
wsstde
-
-
-
g
n
v
vls
r
r
ffe
na
gl
mqs
vi
l
m
g
nk
f
h
nlrkgatd
glrpthplekaak
feef
e
-
-
-
s
kts
m
si
l
q
l
a
-
y
tm
nqq
v
ml
is
c
pfs
dmvvtnekhrdicekkwn
p
a
-
-
dr
variv
a
enpggkyqh
--
ln
c
g
t
q
-
dprn
i
se
a
l
c
l
t
-
d
pa
-
r
d
s
lfk
-
e
p
ellakkpelr
k
v
yatpevskfpvselaedqlndesrelgfylq
f
y
ma
y
n
ll
g
wrf
eg
kagegy
fy
k
d
av
fa
fe
-
----
-
---
-
-
cpahptwlapdewkgta
w
t
r
h
t
v
f
ht
fdl
ki
s
n
q
v
tr
g
kp
-
e
lv
c
q
tdsq
sn
a
i
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character