fig|1040638.4.peg.3619
Escherichia coli O104:H4 str. LB226692
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEP
A
VQQ
RF
EN
AS
K
ES
T
E
F
TK
R
INV
I
G
VT
D
QKGEKI
L
P
DT
TG
P
IA
R
T
N
S
S
YD
G
I
K
R
R
N
P
N
N
VID
M
K
S
R
Q
Y
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
T
WA
A
H
S
DFQ
S
RI
S
T
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
Y
E
S
DF
H
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SRT
IGGL
G
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
K
G
S
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|6666666.5357.peg.2433
Escherichia coli TY-2482
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEP
A
VQQ
RF
EN
AS
K
ES
T
E
F
TK
R
INV
I
G
VT
D
QKGEKI
L
P
DT
TG
P
IA
R
T
N
S
S
YD
G
I
K
R
R
N
P
N
N
VID
M
K
S
R
Q
Y
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
T
WA
A
H
S
DFQ
S
RI
S
T
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
Y
E
S
DF
H
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SRT
IGGL
G
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
K
G
S
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|573235.3.peg.2820
Escherichia coli O26:H11 str. 11368
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEP
A
VQQ
RF
EN
AS
K
ES
T
E
F
TK
R
INV
I
G
VT
D
QKGEKI
L
P
DT
TG
P
IA
R
T
N
S
S
YD
G
I
K
R
R
N
P
N
N
VID
M
K
S
R
Q
Y
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
T
WA
A
H
S
DFQ
S
RI
S
T
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
Y
E
S
DF
H
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SRT
IGGL
G
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
K
G
S
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|585055.6.peg.2140
Escherichia coli 55989
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEP
A
VQQ
RF
EN
AS
K
ES
T
E
F
TK
R
INV
I
G
VT
D
QKGEKI
L
P
DT
TG
P
IA
R
T
N
S
S
YD
G
I
K
R
R
N
P
N
N
VID
M
K
S
R
Q
Y
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
T
WA
A
H
S
DFQ
S
RI
S
T
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
Y
E
S
DF
H
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
VGK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDL
A
VI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SRT
IGGL
G
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
K
G
S
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
I
T
G
L
K
F
A
DS
fig|585055.8.peg.2143
Escherichia coli 55989
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEP
A
VQQ
RF
EN
AS
K
ES
T
E
F
TK
R
INV
I
G
VT
D
QKGEKI
L
P
DT
TG
P
IA
R
T
N
S
S
YD
G
I
K
R
R
N
P
N
N
VID
M
K
S
R
Q
Y
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
T
WA
A
H
S
DFQ
S
RI
S
T
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
Y
E
S
DF
H
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
VGK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDL
A
VI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SRT
IGGL
G
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
K
G
S
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
I
T
G
L
K
F
A
DS
fig|749549.3.peg.5354
Escherichia coli MS 198-1
MNLVM
SDN
A
R
N
K
LG
R
Y
M
T
R
Q
A
S
I
N
N
I
P
V
SG
L
V
S
R
FTVEPSVQQ
RF
EN
AS
K
ES
T
E
F
TK
R
INV
I
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
N
S
S
YD
G
I
K
R
R
N
P
N
N
VID
M
K
S
R
Q
Y
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
T
WA
A
H
S
DFQ
S
RI
S
T
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
Y
E
S
DF
H
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
VGK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDL
A
VI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SRT
IGGL
G
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
K
G
S
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
I
T
G
L
K
F
A
DS
fig|344601.3.peg.3800
Escherichia coli B171
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEPSVQQ
RF
EN
AS
K
ES
T
E
F
TK
R
INV
I
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
NTS
YD
GT
K
R
R
N
P
N
N
VVD
L
K
N
R
KY
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
WA
A
H
P
DFQ
S
RI
S
T
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
D
E
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SRT
IGGL
G
VFL
APFFP
DS
T
MLIT
S
F
N
NLSIYWQ
K
G
S
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|344601.5.peg.3978
Escherichia coli B171
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEPSVQQ
RF
EN
AS
K
ES
T
E
F
TK
R
INV
I
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
NTS
YD
GT
K
R
R
N
P
N
N
VVD
L
K
N
R
KY
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
WA
A
H
P
DFQ
S
RI
S
T
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
D
E
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SRT
IGGL
G
VFL
APFFP
DS
T
MLIT
S
F
N
NLSIYWQ
K
G
S
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|358709.5.peg.4091
Escherichia coli 101-1
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEPSVQQ
RF
EN
AS
K
ES
T
E
F
TK
R
INV
I
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
NTS
YD
GT
K
R
R
N
P
N
N
VVD
L
K
N
R
KY
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
WA
A
H
P
DFQ
S
RI
S
A
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
D
E
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SRT
IGGL
G
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
K
G
S
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|550677.3.peg.1420
Escherichia coli B354
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEPSVQQ
RF
EN
AS
K
ES
T
E
F
TK
R
INV
I
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
NTS
YD
GT
K
R
R
N
P
N
N
VVD
L
K
N
R
KY
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
WA
A
H
P
DFQ
S
RI
S
A
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
D
E
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SRT
IGGL
G
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
K
G
S
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|340185.3.peg.3669
Escherichia coli E22
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEP
A
VQQ
RF
EN
AS
K
ES
T
E
F
TK
R
INV
I
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
NTS
YD
GT
K
R
R
N
P
N
N
VVD
L
K
N
R
KY
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
W
S
A
H
P
DFQ
S
RI
S
A
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
D
E
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SRT
IGGL
G
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
K
G
S
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|340185.4.peg.3860
Escherichia coli E22
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEP
A
VQQ
RF
EN
AS
K
ES
T
E
F
TK
R
INV
I
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
NTS
YD
GT
K
R
R
N
P
N
N
VVD
L
K
N
R
KY
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
W
S
A
H
P
DFQ
S
RI
S
A
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
D
E
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SRT
IGGL
G
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
K
G
S
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|585395.4.peg.1967
Escherichia coli O103:H2 str. 12009
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEPSVQQ
RF
EN
AS
K
ES
T
E
F
TK
R
INV
I
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
NTS
YD
GT
K
R
R
N
P
N
N
VVD
L
K
N
R
KY
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
WA
A
H
P
DFQ
S
RI
S
A
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
D
E
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SRT
IGGL
G
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
K
G
S
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|585396.4.peg.2281
Escherichia coli O111:H- str. 11128
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEPSVQQ
RF
EN
AS
K
ES
T
E
F
TK
R
INV
I
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
NTS
YD
GT
K
R
R
N
P
N
N
VVD
L
K
N
R
KY
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
WA
A
H
P
DFQ
S
RI
S
A
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
D
E
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SRT
IGGL
G
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
K
G
S
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|573235.3.peg.2498
Escherichia coli O26:H11 str. 11368
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEPSVQQ
RF
EN
AS
K
ES
T
E
F
TK
R
INV
I
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
NTS
YD
GT
K
R
R
N
P
N
N
VVD
L
K
N
R
KY
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
WA
A
H
P
DFQ
S
RI
S
A
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
D
E
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SRT
IGGL
G
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
K
G
S
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|701177.3.peg.2129
Escherichia coli O55:H7 str. CB9615
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEPSVQQ
RF
EN
AS
K
ES
T
E
F
TK
R
INV
I
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
NTS
YD
GT
K
R
R
N
P
N
N
VVD
L
K
N
R
KY
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
WA
A
H
P
DFQ
S
RI
S
A
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
D
E
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SRT
IGGL
G
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
K
G
S
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|364106.7.peg.1019
Escherichia coli UTI89
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEPSVQQ
RF
EN
AS
K
ES
T
E
F
TK
R
INV
I
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
NTS
YD
GT
K
R
R
N
P
N
N
VVD
L
K
N
R
KY
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
WA
A
H
P
DFQ
S
RI
S
A
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
D
E
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SRT
IGGL
G
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
K
G
S
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|364106.8.peg.1017
Escherichia coli UTI89
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEPSVQQ
RF
EN
AS
K
ES
T
E
F
TK
R
INV
I
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
NTS
YD
GT
K
R
R
N
P
N
N
VVD
L
K
N
R
KY
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
WA
A
H
P
DFQ
S
RI
S
A
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
D
E
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SRT
IGGL
G
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
K
G
S
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|316401.4.peg.2277
Escherichia coli ETEC H10407
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEPSVQQ
RF
EN
AS
K
ES
T
E
F
TK
R
INV
I
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
NTS
YD
GT
K
R
R
N
P
N
N
VVD
L
K
N
R
KY
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
WA
A
H
P
DFQ
S
RI
S
A
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
D
E
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SRT
IGGL
G
VFL
APFFP
DS
T
MLIT
S
F
N
NLSIYWQ
K
G
S
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|656440.3.peg.2336
Escherichia coli TA206
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEPSVQQ
RF
EN
AS
K
ES
T
E
F
TK
R
INV
I
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
NTS
YD
GT
K
R
R
N
P
N
N
VVD
L
K
N
R
KY
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
WA
A
H
P
DFQ
S
RI
S
A
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
D
E
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SRT
IGGL
G
VFL
APFFP
DS
T
MLIT
S
F
N
NLSIYWQ
K
G
S
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|216593.1.peg.508
Escherichia coli E2348/69
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEPSVQQ
RF
EN
AS
K
ES
T
E
F
TK
R
INV
I
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
NT
G
YD
GT
K
R
R
N
P
N
N
VVD
L
K
N
R
KY
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
WA
A
H
P
DFQ
S
RI
S
A
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
D
E
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SRT
IGGL
G
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
K
G
S
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|574521.7.peg.1856
Escherichia coli O127:H6 str. E2348/69
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEPSVQQ
RF
EN
AS
K
ES
T
E
F
TK
R
INV
I
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
NT
G
YD
GT
K
R
R
N
P
N
N
VVD
L
K
N
R
KY
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
WA
A
H
P
DFQ
S
RI
S
A
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
D
E
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SRT
IGGL
G
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
K
G
S
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|749545.3.peg.2629
Escherichia coli MS 182-1
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEP
A
VQQ
RF
EN
AS
K
ES
T
E
F
TK
R
INV
I
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
NTS
YD
GT
K
R
R
N
P
N
N
VVD
L
K
N
R
KY
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
W
S
A
H
P
DFQ
S
RI
S
A
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
D
E
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
N
A
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SRT
IGGL
G
VFL
APFFP
DS
T
MLIT
S
F
N
NLSIYWQ
K
G
S
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|656393.3.peg.2742
Escherichia coli H299
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEP
A
VQQ
RF
EN
AS
K
D
S
T
E
L
TK
R
INV
I
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
NTS
YD
GT
K
R
R
N
P
N
N
VVN
L
K
N
R
KY
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
W
S
A
H
P
DFQ
S
RI
S
A
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
D
E
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
VGK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SRT
IGGL
G
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
K
G
S
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|340186.3.peg.1445
Escherichia coli E110019
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEPSVQQ
RF
EN
AV
K
ES
T
E
F
TK
K
INV
F
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
NTS
YD
GT
K
R
R
N
P
N
N
VVD
L
K
N
R
KY
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
WA
A
H
P
DFQ
S
R
VS
T
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
D
E
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SR
A
IGGL
D
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
K
GT
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|340186.5.peg.1493
Escherichia coli E110019
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEPSVQQ
RF
EN
AV
K
ES
T
E
F
TK
K
INV
F
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
NTS
YD
GT
K
R
R
N
P
N
N
VVD
L
K
N
R
KY
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
WA
A
H
P
DFQ
S
R
VS
T
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
D
E
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SR
A
IGGL
D
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
K
GT
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|478008.5.peg.4910
Escherichia coli O157:H7 str. EC869
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEPSVQQ
RF
EN
AV
K
ES
T
E
F
TK
K
INV
F
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
NTS
YD
GT
K
R
R
N
P
N
N
VVD
L
K
N
R
KY
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
WA
A
H
P
DFQ
S
R
VS
T
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
D
E
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SR
A
IGGL
D
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
K
GT
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|637388.3.peg.4904
Escherichia coli O157:H7 str. FRIK2000
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEPSVQQ
RF
EN
AV
K
ES
T
E
F
TK
K
INV
F
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
NTS
YD
GT
K
R
R
N
P
N
N
VVD
L
K
N
R
KY
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
WA
A
H
P
DFQ
S
R
VS
T
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
D
E
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SR
A
IGGL
D
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
K
GT
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|409438.11.peg.1999
Escherichia coli SE11
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEPSVQQ
RF
EN
AV
K
ES
T
E
F
TK
K
INV
F
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
NTS
YD
GT
K
R
R
N
P
N
N
VVD
L
K
N
R
KY
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
WA
A
H
P
DFQ
S
R
VS
T
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
D
E
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SR
A
IGGL
D
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
K
GT
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|340184.3.peg.3833
Escherichia coli B7A
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEPSVQQ
RF
EN
AV
K
ES
T
E
F
TK
K
INV
F
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
NTS
YD
GT
K
R
R
N
P
N
N
VVD
L
K
N
R
KY
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
WA
A
H
P
DFQ
S
R
VS
T
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
D
E
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SR
A
IGGL
D
VFL
APFFP
DS
T
MLIT
S
F
N
NLSIYWQ
K
GT
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|340184.6.peg.4001
Escherichia coli B7A
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEPSVQQ
RF
EN
AV
K
ES
T
E
F
TK
K
INV
F
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
NTS
YD
GT
K
R
R
N
P
N
N
VVD
L
K
N
R
KY
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
WA
A
H
P
DFQ
S
R
VS
T
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
D
E
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SR
A
IGGL
D
VFL
APFFP
DS
T
MLIT
S
F
N
NLSIYWQ
K
GT
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|570506.3.peg.4323
Escherichia coli O157:H7 str. FRIK966
MNLVM
SDI
TR
N
K
LGC
Y
M
A
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTVEPSVQQ
RF
EN
AV
K
ES
T
E
F
TK
K
INV
F
G
VT
D
QKGEKI
L
L
DT
TG
P
IA
R
T
NTS
YD
GT
K
R
R
N
P
N
N
VVD
L
K
N
R
KY
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
WA
A
H
P
DFQ
S
R
VS
T
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
A
D
E
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
A
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SR
A
IGGL
D
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
K
GT
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|670897.3.peg.2568
Escherichia coli 2362-75
MNLVM
SDN
A
R
N
K
LGC
Y
M
T
Q
Q
A
S
LN
N
I
P
V
SA
L
V
S
R
FTV
N
PSVQQ
RF
EN
AS
K
ES
T
E
F
TK
R
INV
I
G
VT
D
QKGEK
V
L
L
DT
TG
P
IA
R
T
NTS
YD
GT
D
R
R
N
P
I
N
AVD
M
K
A
R
Q
Y
Q
CEQ
V
N
Y
DT
F
I
S
Y
PK
LD
A
WA
A
H
S
DFQ
S
RI
S
T
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
AE
K
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
DA
S
E
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SRT
IGGL
D
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
R
G
S
M
RR
L
M
K
D
E
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|344601.3.peg.4898
Escherichia coli B171
MNLVM
SDN
A
R
N
K
LGC
Y
M
T
R
Q
A
S
I
N
N
I
P
V
SG
L
V
S
R
FTVEPSVQQ
RF
EN
AS
K
D
S
T
E
L
TK
K
INV
I
G
VT
D
QKGEK
V
L
M
DT
TG
P
IA
R
T
NTS
YD
GT
D
R
R
N
P
I
N
AVD
L
X
S
R
Q
Y
Q
CEQ
V
N
Y
DT
F
I
S
Y
PQ
LD
A
WA
A
H
N
DFQ
T
RI
S
A
Q
I
A
RQV
ALD
R
IMIGFNG
T
S
H
AE
K
SN
F
S
T
N
K
LLQDVNVGWL
EH
IR
T
N
A
S
A
RVM
ND
VT
L
T
S
R
N
MD
NT
V
AH
A
GK
--
-
YAN
A
DALV
Q
DA
R
S
S
L
L
D
E
W
HK
E
A
DDLVVI
M
GR
N
L
F
N
SLRL
P
V
L
N
S
ISGQN
P
N
A
E
L
LA
GQ
L
I
L
S
SRT
IGGL
G
VFL
APFFP
DA
T
MLIT
S
F
N
NLSIYWQ
K
G
S
M
RR
L
M
K
D
X
P
E
Y
N
RI
AT
Y
Q
S
I
N
D
AYVVEDY
GKC
A
M
V
T
G
L
K
F
A
DS
fig|585397.9.peg.902
Escherichia coli ED1a (4-349/366)
L
S
L
SRE
G
R
DS
L
ER
Y
M
I
Q
Q
A
S
L
A
GI
T
T
ER
L
G
K
T
F
S
V
D
PS
I
QQ
K
M
EN
AI
K
ES
A
G
L
L
Q
E
IN
F
I
G
V
D
D
Q
E
GEK
V
LIDT
S
G
P
IA
S
T
N
A
T
SD
G
V
K
R
R
N
P
A
S
VAD
L
D
A
R
R
Y
R
CEQ
V
N
Y
DT
F
I
S
Y
AQ
I
D
A
W
S
S
Q
KN
FQ
Q
L
L
S
A
Q
I
T
RQV
ALD
R
IMIGFNG
E
S
H
A
LI
S
D
R
A
T
N
P
LLQDVN
P
GWL
K
H
IR
D
K
A
A
T
RV
V
KG
M
T
L
T
R
R
D
DE
NK
L
VA
K
G
D
--
-
Y
G
N
P
DA
M
V
H
D
I
R
S
S
V
L
D
E
W
HKDAP
DLVV
L
M
GR
D
L
F
NT
LRL
P
MI
N
A
IS
TT
N
P
N
T
E
L
V
A
GQ
L
I
VA
SRT
V
GGL
Q
TY
L
AP
Y
FP
KD
AMLIT
S
L
K
NLSIY
F
Q
K
G
S
L
RR
F
I
R
EE
P
E
Y
N
RI
AT
Y
Q
SMN
D
C
YVVEDY
GKC
AL
I
E
G
I
T
F
A
fig|585397.7.peg.902
Escherichia coli ED1a (1-332/349)
M
I
Q
Q
A
S
L
A
GI
T
T
ER
L
G
K
T
F
S
V
D
PS
I
QQ
K
M
EN
AI
K
ES
A
G
L
L
Q
E
IN
F
I
G
V
D
D
Q
E
GEK
V
LIDT
S
G
P
IA
S
T
N
A
T
SD
G
V
K
R
R
N
P
A
S
VAD
L
D
A
R
R
Y
R
CEQ
V
N
Y
DT
F
I
S
Y
AQ
I
D
A
W
S
S
Q
KN
FQ
Q
L
L
S
A
Q
I
T
RQV
ALD
R
IMIGFNG
E
S
H
A
LI
S
D
R
A
T
N
P
LLQDVN
P
GWL
K
H
IR
D
K
A
A
T
RV
V
KG
M
T
L
T
R
R
D
DE
NK
L
VA
K
G
D
--
-
Y
G
N
P
DA
M
V
H
D
I
R
S
S
V
L
D
E
W
HKDAP
DLVV
L
M
GR
D
L
F
NT
LRL
P
MI
N
A
IS
TT
N
P
N
T
E
L
V
A
GQ
L
I
VA
SRT
V
GGL
Q
TY
L
AP
Y
FP
KD
AMLIT
S
L
K
NLSIY
F
Q
K
G
S
L
RR
F
I
R
EE
P
E
Y
N
RI
AT
Y
Q
SMN
D
C
YVVEDY
GKC
AL
I
E
G
I
T
F
A
fig|566546.4.peg.2254
Escherichia coli W (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
L
IM
A
GFNGV
R
RAETS
D
RS
S
N
Q
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
K
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
E
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|562.376.peg.1403
Escherichia coli WV_060327 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
L
IM
A
GFNGV
K
RAETS
D
H
S
S
N
P
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
K
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
E
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|550676.3.peg.4146
Escherichia coli B185 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
RIR
N
AI
I
KRQ
S
LD
F
IM
A
GFNGV
K
RAE
N
S
D
RS
S
N
P
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
K
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
E
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|340184.3.peg.4919
Escherichia coli B7A (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
L
IM
A
GFNGV
R
RAETS
D
RS
S
N
Q
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
R
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
E
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|340184.6.peg.5142
Escherichia coli B7A (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
L
IM
A
GFNGV
R
RAETS
D
RS
S
N
Q
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
R
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
E
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|595495.4.peg.5111
Escherichia coli KO11 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
L
IM
A
GFNGV
R
RAETS
D
RS
S
N
Q
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
R
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
E
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|566546.3.peg.5098
Escherichia coli W (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
L
IM
A
GFNGV
R
RAETS
D
RS
S
N
Q
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
R
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
E
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|656408.3.peg.2314
Escherichia coli H591 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
L
IM
A
GFNGV
R
RAETS
D
RS
S
N
P
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
K
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
E
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|344610.3.peg.2232
Escherichia coli 53638 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
F
IM
A
GFNGV
K
RAETS
D
RS
S
N
P
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
K
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
E
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|344610.7.peg.2258
Escherichia coli 53638 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
F
IM
A
GFNGV
K
RAETS
D
RS
S
N
P
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
K
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
E
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|405955.13.peg.887
Escherichia coli APEC O1 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
F
IM
A
GFNGV
K
RAETS
D
RS
S
N
P
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
K
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
E
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|405955.9.peg.741
Escherichia coli APEC O1 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
F
IM
A
GFNGV
K
RAETS
D
RS
S
N
P
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
K
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
E
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|749538.3.peg.817
Escherichia coli MS 116-1 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQALD
L
IM
A
GFNGV
K
RAETS
D
RS
S
N
P
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
R
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
K
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
V
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|595495.4.peg.5109
Escherichia coli KO11 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
L
IM
A
GFNGV
R
RAETS
D
RS
S
N
P
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
R
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
K
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
E
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|566546.3.peg.5096
Escherichia coli W (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
L
IM
A
GFNGV
R
RAETS
D
RS
S
N
P
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
R
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
K
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
E
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|566546.4.peg.4183
Escherichia coli W (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
L
IM
A
GFNGV
R
RAETS
D
RS
S
N
P
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
R
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
K
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
E
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|714962.3.peg.954
Escherichia coli IHE3034 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
RIR
N
AI
I
KRQ
S
LD
F
IM
A
GFNGV
K
RAE
N
S
D
RS
S
N
P
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
K
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
V
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|749546.3.peg.2586
Escherichia coli MS 185-1 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
F
IM
A
GFNGV
K
RAETS
D
RS
S
N
P
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
R
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
K
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
E
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|478008.5.peg.4142
Escherichia coli O157:H7 str. EC869 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
F
IM
A
GFNGV
K
RAETS
D
RS
S
N
P
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
R
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
K
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
E
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|637388.3.peg.2162
Escherichia coli O157:H7 str. FRIK2000 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
F
IM
A
GFNGV
K
RAETS
D
RS
S
N
P
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
R
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
K
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
E
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|570506.3.peg.3503
Escherichia coli O157:H7 str. FRIK966 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
F
IM
A
GFNGV
K
RAETS
D
RS
S
N
P
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
R
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
K
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
E
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|562.375.peg.4463
Escherichia coli EC4100B (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
S
T
-
T
G
G
E
TT
PR
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|656408.3.peg.876
Escherichia coli H591 (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
S
T
-
T
G
G
E
TT
PR
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|562.373.peg.17
Escherichia coli 1125A (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
L
IM
A
GFNGV
R
RAETS
D
RS
S
N
Q
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
R
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
V
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|444454.5.peg.1782
Escherichia coli O157:H7 str. EC4024 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
L
IM
A
GFNGV
R
RAETS
D
RS
S
N
Q
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
R
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
V
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|444449.5.peg.1258
Escherichia coli O157:H7 str. EC4042 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
L
IM
A
GFNGV
R
RAETS
D
RS
S
N
Q
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
R
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
V
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|444448.5.peg.21
Escherichia coli O157:H7 str. EC4045 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
L
IM
A
GFNGV
R
RAETS
D
RS
S
N
Q
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
R
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
V
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|444453.5.peg.3751
Escherichia coli O157:H7 str. EC4076 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
L
IM
A
GFNGV
R
RAETS
D
RS
S
N
Q
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
R
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
V
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|444452.5.peg.5219
Escherichia coli O157:H7 str. EC4113 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
L
IM
A
GFNGV
R
RAETS
D
RS
S
N
Q
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
R
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
V
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|444450.8.peg.3052
Escherichia coli O157:H7 str. EC4115 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
L
IM
A
GFNGV
R
RAETS
D
RS
S
N
Q
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
R
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
V
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|444451.5.peg.3516
Escherichia coli O157:H7 str. EC4196 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
L
IM
A
GFNGV
R
RAETS
D
RS
S
N
Q
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
R
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
V
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|444447.5.peg.153
Escherichia coli O157:H7 str. EC4206 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
L
IM
A
GFNGV
R
RAETS
D
RS
S
N
Q
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
R
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
V
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|478004.5.peg.3059
Escherichia coli O157:H7 str. EC4401 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
L
IM
A
GFNGV
R
RAETS
D
RS
S
N
Q
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
R
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
V
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|478005.5.peg.5341
Escherichia coli O157:H7 str. EC4486 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
L
IM
A
GFNGV
R
RAETS
D
RS
S
N
Q
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
R
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
V
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|478007.5.peg.1783
Escherichia coli O157:H7 str. EC508 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
L
IM
A
GFNGV
R
RAETS
D
RS
S
N
Q
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
R
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
V
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|544404.4.peg.2914
Escherichia coli O157:H7 str. TW14359 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
L
IM
A
GFNGV
R
RAETS
D
RS
S
N
Q
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
R
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
V
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|439855.10.peg.4456
Escherichia coli SMS-3-5 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
F
IM
A
GFNGV
K
RAETS
D
RS
S
N
P
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
K
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
V
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|749531.3.peg.3073
Escherichia coli MS 69-1 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
Q
I
L
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
RIR
N
AI
I
KRQ
S
LD
F
IM
A
GFNGV
K
RAETS
D
RS
S
N
P
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
YA
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
K
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
V
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|656444.3.peg.5276
Escherichia coli TA280 (1-344/357)
M
RQE
TRFKFNAYL
S
R
V
A
E
LNGI
D
A
GD
V
S
K
KFTVEPSV
T
QTL
M
N
TM
QESS
D
FLT
R
IN
I
V
PV
S
E
M
KGEKIG
I
GVTG
S
IA
S
TTDT
AG
GTERQ
-
P
K
D
FSK
L
A
S
N
KYEC
D
Q
I
NFD
F
Y
I
R
Y
KT
LDLWA
R
YQDFQ
L
R
V
R
N
AI
I
KRQ
S
LD
F
IM
A
GFNGV
K
RAETS
D
RS
S
N
P
M
LQDV
A
VGWLQK
Y
R
N
E
AP
A
RVM
SK
VT
D
E
E
G
H
TT
SE
V
IR
VGKGG
D
Y
V
S
LDALVMDA
T
N
N
LI
E
P
WYQED
P
DLVVI
V
GR
Q
LLADKYFPIVN
K
---
EQ
D
NSE
M
LAADVIISQKRIG
N
L
P
AVR
V
P
Y
FP
AD
AMLIT
K
LENLSIY
YM
DDS
H
RR
V
I
E
E
NPK
L
DR
V
ENYESMN
I
D
YVVEDY
AAG
C
LVE
K
IK
V
GD
fig|585397.7.peg.3093
Escherichia coli ED1a (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
N
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|585397.9.peg.3090
Escherichia coli ED1a (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
N
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|670888.3.peg.1428
Escherichia coli 1827-70 (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
N
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|679204.3.peg.2518
Escherichia coli MS 145-7 (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
M
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|331112.3.peg.856
Escherichia coli HS (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|331112.6.peg.894
Escherichia coli HS (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|585057.4.peg.1888
Escherichia coli IAI39 (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|585057.6.peg.1887
Escherichia coli IAI39 (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|656417.3.peg.1056
Escherichia coli M605 (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|753642.3.peg.793
Escherichia coli NC101 (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|585035.6.peg.2789
Escherichia coli S88 (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|656437.3.peg.951
Escherichia coli TA143 (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|656444.3.peg.1423
Escherichia coli TA280 (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|481805.3.peg.2984
Escherichia coli ATCC 8739 (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|481805.6.peg.2973
Escherichia coli ATCC 8739 (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|595495.4.peg.3993
Escherichia coli KO11 (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|656440.3.peg.726
Escherichia coli TA206 (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|566546.3.peg.4314
Escherichia coli W (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|566546.4.peg.913
Escherichia coli W (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|679205.4.peg.2141
Escherichia coli MS 124-1 (1-342/352)
M
KKN
TRF
A
F
K
AYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|749533.3.peg.4881
Escherichia coli MS 84-1 (1-342/352)
M
KKN
TRF
A
F
K
AYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|670897.3.peg.4760
Escherichia coli 2362-75 (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
D
S
P
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|216593.1.peg.1464
Escherichia coli E2348/69 (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
D
S
P
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|574521.7.peg.838
Escherichia coli O127:H6 str. E2348/69 (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
D
S
P
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|679207.4.peg.2082
Escherichia coli MS 107-1 (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDL
M
VI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|199310.1.peg.925
Escherichia coli CFT073 (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NF
N
T
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|199310.4.peg.907
Escherichia coli CFT073 (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NF
N
T
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
E
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
GGL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
fig|749537.3.peg.163
Escherichia coli MS 115-1 (1-342/352)
M
KKN
TRF
A
FNAYL
Q
Q
L
A
R
LNG
V
A
V
EE
LSSKFTVEPSVQQTLE
D
QI
Q
Q
S
A
A
FLT
L
INV
T
PVTEQ
S
G
QLL
GLGV
GS
T
IA
G
TTDT
T-
AK
ER
E
-
P
V
D
PTL
M
V
D
V
E
Y
K
CEQ
T
NFDT
V
L
T
Y
AK
LDLWA
K
F
QDFQ
V
RIR
D
AI
V
KRQALD
R
IMIGFNGV
K
RA
K
TSNRS
D
N
P
LLQDVN
K
GWLQKIR
E
DAP
D
H
VM
GS
T
T
-
T
G
G
E
TT
PG
A
VK
VGKGG
E
YANLDA
V
VMDA
V
N
E
LID
V
V
YQ
D
DDDLVVI
C
GR
E
LL
S
DKYFP
L
VN
K
---
EQ
E
NSE
K
LAAD
M
IISQKR
M
V
GL
Q
AVRAPFFP
PN
A
L
LIT
R
L
D
NLSIYWQ
E
D
T
R
RR
S
V
I
DNPK
R
DRIEN
F
ES
V
N
E
AYVVEDY
RCA
ALVE
N
I
Q
I
GD
Consen1
Primary consensus
MNLVM
TRfkfnaYl
q
A
LNgi
v
lsskFTVEPSVqQtlen
qeSs
Flt
INv
pVteqkGekiglgvtg
IA
Ttdt
gteRq
-
P
d
l
s
kYeCeQ
NfDt
i
Y
LDlWA
yqDFQ
Rir
aI
krqaLD
IMiGFNGv
rAetSnrS
N
lLQDVnvGWLqkiR
dAp
rVM
vT
t
g
tt
v
vGKgg
YAnlDAlVmDA
n
Lid
wyqeddDLVVI
GR
LladkyfPivN
---
eq
NsE
LAadvIiSqkriGgL
avraPfFP
amLIT
leNLSIYwqdds
RR
i
dnPk
dRienyeSmN
aYVVEDY
alVe
ik
gDS
Consen2
Secondary consensus
nalgc
m
r
nv
a
vvkr
t
rfmd
kq
tk
i
g
sdms
qlllidtgs
nts
akk
n
n
m
e
d
y
f
l
a
p
vs
q
rqvs
a
t
h
e
df
m
ak
ehy
e
s
h
t
e
r
md
a
a
--
sa
v
q
s
le
vhkdap
f
slrl
l
isgqn
a
gq
l
srtm
n
vflv
y
tl
f
ym
gt
ee
e
n
vatfq
d
cm
t
lq
a
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character