fig|6666666.5357.peg.2435
Escherichia coli TY-2482 (89-576/576)
MA
A
GK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
S
A
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
S
AQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
S
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
L
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
Y
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|1040638.4.peg.3615
Escherichia coli O104:H4 str. LB226692
MA
A
GK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
S
A
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
S
AQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
S
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
L
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
Y
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|714962.3.peg.2622
Escherichia coli IHE3034 (96-583/583)
MA
A
GK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
S
AQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
S
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
L
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
Y
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|573235.3.peg.2496
Escherichia coli O26:H11 str. 11368 (96-583/583)
MA
A
GK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
S
AQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
S
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
L
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
Y
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|364106.7.peg.1021
Escherichia coli UTI89 (96-583/583)
MA
A
GK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
S
AQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
S
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
L
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
Y
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|364106.8.peg.1019
Escherichia coli UTI89 (96-583/583)
MA
A
GK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
S
AQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
S
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
L
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
Y
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|550677.3.peg.1418
Escherichia coli B354 (97-583/583)
ATGK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
S
AQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
S
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
L
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
Y
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|656393.3.peg.2740
Escherichia coli H299 (97-583/583)
ATGK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
S
AQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
S
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
L
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
Y
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|701177.3.peg.2127
Escherichia coli O55:H7 str. CB9615 (97-583/583)
ATGK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
S
AQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
S
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
L
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
Y
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|656440.3.peg.2334
Escherichia coli TA206 (97-583/583)
ATGK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
S
AQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
S
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
L
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
Y
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|216593.1.peg.506
Escherichia coli E2348/69 (97-583/583)
A
A
GK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
S
AQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
S
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
L
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
Y
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
H
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|574521.7.peg.1854
Escherichia coli O127:H6 str. E2348/69 (97-583/583)
A
A
GK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
S
AQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
S
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
L
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
Y
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
H
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|670897.3.peg.2566
Escherichia coli 2362-75 (99-583/583)
GK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
S
AQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
S
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
L
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
Y
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|316401.4.peg.2275
Escherichia coli ETEC H10407 (96-583/583)
MA
A
GK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
S
AQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
T
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
R
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
C
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|585396.4.peg.2279
Escherichia coli O111:H- str. 11128 (96-583/583)
MA
A
GK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
S
A
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
S
AQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
T
H
KR
R
R
FS
V
DW
NT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
L
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
C
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|585395.4.peg.1965
Escherichia coli O103:H2 str. 12009 (97-583/583)
ATGK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
S
AQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
S
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
L
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
C
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|344601.3.peg.4900
Escherichia coli B171 (96-583/583)
MA
A
GK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
TAQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
T
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
R
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
C
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|344601.5.peg.5211
Escherichia coli B171
MA
A
GK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
TAQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
T
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
R
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
C
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|340185.3.peg.3667
Escherichia coli E22 (96-583/583)
MA
A
GK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
S
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
S
AQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
S
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
L
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
H
P
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
C
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|340185.4.peg.3858
Escherichia coli E22 (96-583/583)
MA
A
GK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
S
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
S
AQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
S
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
L
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
H
P
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
C
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|585055.6.peg.2138
Escherichia coli 55989 (97-583/583)
ATGK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
S
AQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
T
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
L
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
D
F
T
Y
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARG
S
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|585055.8.peg.2141
Escherichia coli 55989 (97-583/583)
ATGK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
S
AQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
T
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
L
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
D
F
T
Y
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARG
S
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|340184.3.peg.3835
Escherichia coli B7A (97-583/583)
ATGK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDV
V
QPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
S
AQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
T
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
L
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
C
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|340184.6.peg.4003
Escherichia coli B7A (97-583/583)
ATGK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDV
V
QPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
S
AQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
T
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
L
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
C
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|749545.3.peg.2627
Escherichia coli MS 182-1 (97-583/583)
ATGK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
S
AQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
T
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
E
-
HT
DID
EI
R
D
EN
T
E
DEF
H
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PP
S
VPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
C
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|749549.3.peg.5352
Escherichia coli MS 198-1 (97-583/583)
ATGK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
E
A
A
S
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
TAQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
S
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
L
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
C
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|358709.5.peg.4089
Escherichia coli 101-1 (96-583/583)
MA
A
GK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLC
K
E
AEI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
S
AQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
H
W
N
EKK
-
A
T
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
R
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
C
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|344601.3.peg.3798
Escherichia coli B171 (99-583/583)
GK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
S
AQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
S
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
L
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
C
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
XE
N
E
R
X
TV
MEF
fig|344601.5.peg.3976
Escherichia coli B171 (99-583/583)
GK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLCRE
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
S
AQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
AY
W
N
G
D
RW
N
EKK
-
A
S
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
L
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
C
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
XE
N
E
R
X
TV
MEF
fig|340186.3.peg.1443
Escherichia coli E110019 (97-583/583)
ATGK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLC
S
E
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
TAQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
V
Y
W
N
G
D
RW
N
EKK
-
A
A
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
R
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
C
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|340186.5.peg.1491
Escherichia coli E110019 (97-583/583)
ATGK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLC
S
E
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
TAQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
V
Y
W
N
G
D
RW
N
EKK
-
A
A
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
R
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
C
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|409438.11.peg.1997
Escherichia coli SE11 (97-583/583)
ATGK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLC
S
E
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
TAQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
V
Y
W
N
G
D
RW
N
EKK
-
A
A
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
R
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
C
R
YNVE
H
IGID
V
T
G
G
N
G
E
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|478008.5.peg.4908
Escherichia coli O157:H7 str. EC869 (97-583/583)
ATGK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLC
S
E
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
TAQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
V
Y
W
N
G
D
RW
N
EKK
-
A
A
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
R
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
C
R
YNVE
H
IGID
A
T
G
G
H
G
D
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|637388.3.peg.4906
Escherichia coli O157:H7 str. FRIK2000 (97-583/583)
ATGK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLC
S
E
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
TAQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
V
Y
W
N
G
D
RW
N
EKK
-
A
A
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
R
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
C
R
YNVE
H
IGID
A
T
G
G
H
G
D
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|570506.3.peg.4321
Escherichia coli O157:H7 str. FRIK966 (97-583/583)
ATGK
---------------
K
GR
A
K
K
L
KN
H
FT
P
EQI
AA
L
R
E
KI
I
S
RL
E
W
H
QR
G
W
F
D
SLTLC
S
E
AGI
R
N
R
M
ILKSRQIGAT
W
YFA
Q
EALL
M
AL
R
DDVAQPYQ
RNQIFLSAS
R
R
QA
F
Q
FK
S
I
I
Q
K
A
A
A
-
EVDVELK
G
GD
K
I
I
L
-
S
NGA
E
L
H
FLGT
S
A
A
TAQSY
T
GN
F
Y
F
DE
F
FW
VS
R
F
A
ELRKVA
GA
MA
TL
S
G
LR
R
TYFSTPST
E
TH
E
AY
V
Y
W
N
G
D
RW
N
EKK
-
A
A
H
KR
Q
R
FS
V
DW
KT
L
H
N
GL
I
C
P
D
RT
WRQIVT
L
ED
V
V
N
H
G
W
K
-
HT
DID
EI
R
D
EN
T
E
DEF
R
NL
Y
MCEFV
RE
G
E
S
A
F
N
L
N
I
L
I
G
C
G
VD
GY
D
D
W
K
DW
K
PFA
P
RP
M
G
N
RPVWIGYD
A
NGS
S
G
NGDS
GAVS
VV
V
PPAVPGG
R
FR
TV
E
TRRV
QG
LE
F
EE
QA
RV
IE
EF
T
C
R
YNVE
H
IGID
A
T
G
G
H
G
D
A
VY
QI
VK
R
FFP
-
AA
I
PYT
F
T
L
SS
K
R
S
LVLK
M
L
Q
I
M
R
A
GR
W
EY
--------
D
RAE
REL
VA
A
F
N
A
V
RK
VK
T
P
G
G
-FI
TYE
TD
R
ARGI
SH
G
DLAWATM
L
A
V
I
NEP
I
G
GE
GE
N
E
R
FTV
MEF
fig|585397.7.peg.904
Escherichia coli ED1a (98-577/577)
S
GK
---------------
KP
RR
R
K
L
KN
H
FT
E
EQI
V
A
L
R
E
KI
L
P
SL
A
W
H
QR
E
WY
D
N
-----
-
RHH
R
N
R
M
ILKSRQIGAT
W
YFAREALL
D
AL
R
DDV
SAG
YQ
RNQIFLSAS
R
R
QAY
Q
FK
H
F
I
Q
Q
A
A
L
-
EVDVELK
G
GD
K
IVL
-
S
NGA
E
L
H
FLGT
S
A
A
TAQSY
T
G
H
L
K
F
DE
F
FW
VS
N
F
V
ELRKVA
GA
MA
TL
E
G
L
T
R
TYFSTPS
G
E
TH
E
AY
Q
FW
T
G
D
RW
N
SE
Q
-
P
R
S
KR
S
E
F
DVSH
AH
L
K
G
G
V
L
F
P
D
E
T
WRQIVTIEDAV
A
N
G
W
R
-
Y
T
N
I
GV
I
R
S
EN
T
E
S
EF
R
NL
Y
MCEFV
R
D
G
E
A
A
F
S
L
S
A
L
T
G
C
G
VD
GY
D
E
W
P
DW
K
PFA
A
RP
M
G
V
R
E
VW
L
GYD
A
NGS
S
G
K
GD
C
GA
L
S
V
C
V
PP
L
V
A
GG
R
FR
TV
E
T
V
RV
QGM
E
F
EQ
QA
AL
IE
E
Y
T
Q
KYNV
K
H
IGID
V
T
G
G
N
G
E
GVY
QI
VK
K
FFP
-
M
A
V
PYN
FN
I
AS
K
R
ALV
M
K
M
L
QV
V
R
A
GR
W
EY
--------
D
RSE
R
D
L
IQ
A
F
A
S
V
RK
IQ
T
P
G
G
-YI
TY
D
TD
RS
RG
V
SH
G
DLAWATM
L
A
V
I
NEP
I
G
A
E
RE
D
N
R
GFA
MEF
fig|585397.9.peg.904
Escherichia coli ED1a (98-577/577)
S
GK
---------------
KP
RR
R
K
L
KN
H
FT
E
EQI
V
A
L
R
E
KI
L
P
SL
A
W
H
QR
E
WY
D
N
-----
-
RHH
R
N
R
M
ILKSRQIGAT
W
YFAREALL
D
AL
R
DDV
SAG
YQ
RNQIFLSAS
R
R
QAY
Q
FK
H
F
I
Q
Q
A
A
L
-
EVDVELK
G
GD
K
IVL
-
S
NGA
E
L
H
FLGT
S
A
A
TAQSY
T
G
H
L
K
F
DE
F
FW
VS
N
F
V
ELRKVA
GA
MA
TL
E
G
L
T
R
TYFSTPS
G
E
TH
E
AY
Q
FW
T
G
D
RW
N
SE
Q
-
P
R
S
KR
S
E
F
DVSH
AH
L
K
G
G
V
L
F
P
D
E
T
WRQIVTIEDAV
A
N
G
W
R
-
Y
T
N
I
GV
I
R
S
EN
T
E
S
EF
R
NL
Y
MCEFV
R
D
G
E
A
A
F
S
L
S
A
L
T
G
C
G
VD
GY
D
E
W
P
DW
K
PFA
A
RP
M
G
V
R
E
VW
L
GYD
A
NGS
S
G
K
GD
C
GA
L
S
V
C
V
PP
L
V
A
GG
R
FR
TV
E
T
V
RV
QGM
E
F
EQ
QA
AL
IE
E
Y
T
Q
KYNV
K
H
IGID
V
T
G
G
N
G
E
GVY
QI
VK
K
FFP
-
M
A
V
PYN
FN
I
AS
K
R
ALV
M
K
M
L
QV
V
R
A
GR
W
EY
--------
D
RSE
R
D
L
IQ
A
F
A
S
V
RK
IQ
T
P
G
G
-YI
TY
D
TD
RS
RG
V
SH
G
DLAWATM
L
A
V
I
NEP
I
G
A
E
RE
D
N
R
GFA
MEF
fig|749537.3.peg.166
Escherichia coli MS 115-1 (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
S
K
A
D
K
V
D
ID
L
SH
SN
LA
P
GLLCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|413997.3.peg.874
Escherichia coli B str. REL606 (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDPIVL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
SN
LA
P
GLLC
T
DGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
I
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|511693.5.peg.896
Escherichia coli BL21 (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDPIVL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
SN
LA
P
GLLC
T
DGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
I
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|469008.4.peg.2865
Escherichia coli BL21(DE3) (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDPIVL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
SN
LA
P
GLLC
T
DGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
I
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|670888.3.peg.1426
Escherichia coli 1827-70 (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
RN
LA
P
GLLCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
ST
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|656417.3.peg.1054
Escherichia coli M605 (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
SN
LA
P
GLLCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
F
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|679205.4.peg.2138
Escherichia coli MS 124-1 (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
SN
LA
P
GLLCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
S
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|749533.3.peg.4878
Escherichia coli MS 84-1 (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
SN
LA
P
GLLCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
S
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|670897.3.peg.4763
Escherichia coli 2362-75 (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
NN
LA
P
GLLCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|216593.1.peg.1462
Escherichia coli E2348/69 (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
NN
LA
P
GLLCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|753642.3.peg.796
Escherichia coli NC101 (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
N
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
SN
LA
P
GLLCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|574521.7.peg.836
Escherichia coli O127:H6 str. E2348/69 (101-564/572)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
NN
LA
P
GLLCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|481805.3.peg.2986
Escherichia coli ATCC 8739 (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
SN
LA
P
GLLCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|481805.6.peg.2975
Escherichia coli ATCC 8739 (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
SN
LA
P
GLLCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|585397.7.peg.3095
Escherichia coli ED1a (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
SN
LA
P
GLLCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|585397.9.peg.3092
Escherichia coli ED1a (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
SN
LA
P
GLLCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|656408.3.peg.873
Escherichia coli H591 (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
SN
LA
P
GLLCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|331112.3.peg.854
Escherichia coli HS (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
SN
LA
P
GLLCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|331112.6.peg.892
Escherichia coli HS (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
SN
LA
P
GLLCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|679207.4.peg.2084
Escherichia coli MS 107-1 (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
SN
LA
P
GLLCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|679204.3.peg.2521
Escherichia coli MS 145-7 (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
SN
LA
P
GLLCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|585035.6.peg.2792
Escherichia coli S88 (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
SN
LA
P
GLLCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|656437.3.peg.948
Escherichia coli TA143 (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
SN
LA
P
GLLCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|656440.3.peg.723
Escherichia coli TA206 (60-523/531)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
SN
LA
P
GLLCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|595495.4.peg.3996
Escherichia coli KO11 (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
R
A
D
K
V
D
ID
L
SH
SN
LA
P
GLLCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|566546.3.peg.4317
Escherichia coli W (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
R
A
D
K
V
D
ID
L
SH
SN
LA
P
GLLCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|566546.4.peg.910
Escherichia coli W (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
R
A
D
K
V
D
ID
L
SH
SN
LA
P
GLLCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|562.375.peg.4460
Escherichia coli EC4100B (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDPIVL
-
P
D
GA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
NN
LA
P
GLLCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|656444.3.peg.1420
Escherichia coli TA280 (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
SN
LA
P
GLLCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
L
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|199310.1.peg.921
Escherichia coli CFT073 (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
NN
LA
P
G
Q
LCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|199310.4.peg.904
Escherichia coli CFT073 (117-580/588)
K
---------------
G
P
RR
Q
P
E
KN
V
FTDEQIEKLEEIF
H
S
SM
F
N
YQRHW
W
E
A
-----
G
KTN
RIR
N
L
LKSRQIGATFYFAREAL
I
D
AL
L
TG
------
RNQIFLSASK
A
QA
H
VFK
Q
YII
D
FA
K
-
EV
E
VELK
-
GDP
M
VL
-
P
NGA
T
L
Y
FLGTNA
R
TAQSY
H
GNLY
L
DE
Y
FWIP
K
FQELRKVASGMA
IH
K
K
W
R
Q
TYFSTPS
S
LTH
S
AYPFWSG
A
LFNRGR
-
N
K
A
D
K
V
D
ID
L
SH
NN
LA
P
G
Q
LCADGQ
Y
RQIVT
V
EDAV
R
GGC
N
-
LFD
L
DQLR
M
E
Y
S
P
DE
Y
Q
NL
L
MCEFVDD
L
ASVFPL
S
ELQ
A
CMVD
SW
E
V
W
T
D
F
H
AL
A
L
RPFG
W
R
E
VWIGYDP
AKG
T
Q
NGDSAGCVVVAPPAVPGGKFRILERHQW
R
GMDF
RA
QA
DA
I
K
KLT
E
Q
YNV
T
YIGID
S
T
-
G
V
G
H
GVY
EN
VK
A
FFP
-
A
V
R
EFV
Y
N
P
NV
K
N
ALVLKA
Y
DII
S
H
R
RLE
F
--------
D
AGH
TDI
AQ
SFMAIR
R
AT
T
A
SG
NRP
TYEASRSEEASHADLAWATMHAL
F
NEPL
Q
GE
SA
N
fig|550676.3.peg.4144
Escherichia coli B185 (118-574/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
E
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
NGA
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
D
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
E
LT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
QL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
fig|656408.3.peg.2316
Escherichia coli H591 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
E
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
NGA
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
QL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|749538.3.peg.815
Escherichia coli MS 116-1 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
E
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
NGA
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
QL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|749531.3.peg.3071
Escherichia coli MS 69-1 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
E
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
NGA
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
QL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|585035.6.peg.2195
Escherichia coli S88 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
E
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
NGA
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
QL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|566546.4.peg.2256
Escherichia coli W (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
E
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
NGA
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
QL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|566546.4.peg.4180
Escherichia coli W (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
E
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
NGA
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
QL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|562.376.peg.1406
Escherichia coli WV_060327 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
D
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
NGA
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
L
Y
NRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
QL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|344610.3.peg.2234
Escherichia coli 53638 (128-599/600)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
D
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
NGA
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
QL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|344610.7.peg.2260
Escherichia coli 53638 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
D
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
NGA
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
QL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|405955.13.peg.885
Escherichia coli APEC O1 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
D
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
NGA
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
QL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|405955.13.peg.2286
Escherichia coli APEC O1 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
D
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
NGA
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
QL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|405955.9.peg.739
Escherichia coli APEC O1 (128-599/600)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
D
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
NGA
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
QL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|405955.9.peg.1866
Escherichia coli APEC O1 (128-599/600)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
D
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
NGA
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
QL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|714962.3.peg.952
Escherichia coli IHE3034 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
D
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
NGA
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
QL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|749546.3.peg.2589
Escherichia coli MS 185-1 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
D
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
NGA
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
QL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|478008.5.peg.4144
Escherichia coli O157:H7 str. EC869 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
D
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
NGA
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
QL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|637388.3.peg.2160
Escherichia coli O157:H7 str. FRIK2000 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
D
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
NGA
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
QL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|570506.3.peg.3505
Escherichia coli O157:H7 str. FRIK966 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
D
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
NGA
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
QL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|439855.10.peg.4454
Escherichia coli SMS-3-5 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
D
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
NGA
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
QL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|656444.3.peg.5274
Escherichia coli TA280 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
D
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
NGA
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
T
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
QL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|562.373.peg.15
Escherichia coli 1125A (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
E
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
N
S
A
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
LL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|444454.5.peg.1784
Escherichia coli O157:H7 str. EC4024 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
E
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
N
S
A
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
LL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|444449.5.peg.1260
Escherichia coli O157:H7 str. EC4042 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
E
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
N
S
A
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
LL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|444448.5.peg.23
Escherichia coli O157:H7 str. EC4045 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
E
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
N
S
A
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
LL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|444453.5.peg.3753
Escherichia coli O157:H7 str. EC4076 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
E
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
N
S
A
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
LL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|444452.5.peg.5217
Escherichia coli O157:H7 str. EC4113 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
E
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
N
S
A
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
LL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|444450.8.peg.3054
Escherichia coli O157:H7 str. EC4115 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
E
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
N
S
A
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
LL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|444451.5.peg.3514
Escherichia coli O157:H7 str. EC4196 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
E
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
N
S
A
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
LL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|444447.5.peg.155
Escherichia coli O157:H7 str. EC4206 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
E
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
N
S
A
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
LL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|478004.5.peg.3061
Escherichia coli O157:H7 str. EC4401 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
E
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
N
S
A
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
LL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|478005.5.peg.3877
Escherichia coli O157:H7 str. EC4486 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
E
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
N
S
A
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
LL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|478007.5.peg.1781
Escherichia coli O157:H7 str. EC508 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
E
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
N
S
A
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
LL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|544404.4.peg.2916
Escherichia coli O157:H7 str. TW14359 (118-589/590)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
E
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
N
S
A
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFNRGR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GMDF
AT
QA
ES
I
R
KLT
E
KYNVEYIGID
A
T
-
G
L
G
V
GV
F
LL
V
R
S
F
Y
P
-
AAR
DIR
YTP
EM
K
T
A
M
VLKA
K
D
V
IR
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|340184.3.peg.3120
Escherichia coli B7A (58-529/530)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
D
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
NGA
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFN
X
GR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GM
X
F
AX
Q
X
ES
I
R
KLT
E
KYN
X
EYIGID
A
T
-
G
L
G
V
GV
F
QL
V
R
S
F
Y
P
-
AAR
XIR
YTP
EM
K
T
A
M
VLKA
K
D
XX
R
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|340184.6.peg.3259
Escherichia coli B7A (58-529/530)
K
---------------
GGRRKP
K
KN
F
F
S
DE
A
IEKLE
Q
IF
F
E
QS
F
D
YQ
L
HWY
R
A
-----
G
LEH
RIR
D
ILKSRQIGATFYF
S
REALL
R
AL
K
TG
------
H
NQIFLSASK
T
QAYVF
R
E
YII
A
FA
R
-
L
VDV
D
L
T
-
GDPIVL
G
N
NGA
K
L
I
FLGTN
S
N
TAQS
H
N
G
D
LY
V
DE
I
FWIP
N
FQ
V
LRKVASGMA
SQ
S
H
LR
S
TYFSTPSTL
A
H
D
AYPFWSG
E
LFN
X
GR
A
S
A
A
E
RV
E
IDVSH
NA
LA
G
GLLCADGQWRQIVTIEDA
L
K
GGC
T
-
LFDI
E
QL
K
R
ENS
A
D
D
F
K
NL
F
MCEFVDD
K
ASVFP
F
E
ELQ
R
CMVD
TL
E
E
W
E
D
Y
A
PFA
A
N
PFG
S
RPVWIGYDP
---
S
H
R
GDSAGCVV
L
APP
V
V
A
GGKFRILERHQW
K
GM
X
F
AX
Q
X
ES
I
R
KLT
E
KYN
X
EYIGID
A
T
-
G
L
G
V
GV
F
QL
V
R
S
F
Y
P
-
AAR
XIR
YTP
EM
K
T
A
M
VLKA
K
D
XX
R
R
G
C
LEY
--------
D
VSA
TDI
TS
SFMAIRK
TM
T
S
SG
RSA
TYEASRSEEASHADLAWATMHAL
L
NEPL
T
AG
IS
T
P
L
TST
ILE
F
fig|550672.3.peg.1065
Escherichia coli B088 (101-579/591)
MA
S
G
Q
SNGQAAARDSNSDEPR
P
K
RK
N
R
KN
D
I
S
SLTQ
A
DF
D
IWA
E
E
HL
F
E
YQ
K
H
LR
R
N
-----
-
IGQ
QV
R
N
ILKSRQIGAT
W
YFA
F
EA
FE
N
A
V
M
TG
------
DP
QIFLSASK
V
QA
EY
F
R
S
YI
V
N
I
A
E
QYFG
I
T
L
T
-
G
N
PI
R
L
-
S
NGA
E
L
R
FL
S
TN
K
N
TAQSY
S
G
H
LY
C
DE
Y
FW
V
P
N
F
A
R
L
N
E
VAS
A
MA
TH
D
K
W
R
T
TYFSTPS
AK
TH
Q
AYPFW
T
G
E
E
W
K
Q
G
S
-
K
K
RAAA
Q
F
PSFD
EM
RN
G
G
R
LC
P
DGQWR
Y
VI
T
M
EDA
I
A
GG
F
N
-
L
A
N
I
E
K
LR
N
R
Y
N
T
AT
F
N
M
L
Y
MC
V
FVD
S
K
D
SVF
S
F
S
D
L
E
A
C
G
V
E
-V
D
T
W
Q
D
H
N
P
D
A
A
RPFG
D
RPVW
G
G
F
DP
---
A
R
S
GD
L
S
CF
V
II
APP
MY
A
AE
KFR
V
L
K
VIN
W
K
GM
N
F
RY
QA
RQ
IE
L
L
F
K
KYN
F
T
Y
L
G
V
D
V
T
-
G
I
G
Q
GV
F
DN
IQ
H
F
AMRV
A
V
AIR
Y
DM
NT
K
N
Q
LVLKA
A
D
V
V
E
S
Q
R
I
E
W
--------
D
KNL
K
E
I
PA
SFMA
V
R
R
TT
T
Q
SG
NAM
T
F
V
A
D
RS
QD
TG
HA
E
AF
WA
IT
HAL
H
NEPL
N
Y
E
NK
fig|562.375.peg.2331
Escherichia coli EC4100B (120-590/603)
A
G
G
E
PG
-------------
ER
K
R
R
Y
K
KN
D
V
S
GITA
E
M
L
D
TWA
Q
E
HL
F
E
YQ
L
H
CR
E
H
-----
-
KGE
DW
R
F
ILKSRQ
V
G
M
T
Y
YFA
W
EA
FE
D
A
V
I
TG
------
D
NQ
V
F
F
SAS
R
S
Q
S
E
I
F
R
E
YI
V
Q
I
A
Q
NHFG
V
T
L
T
-
G
KN
I
R
L
-
S
NGA
I
L
R
FL
S
TNA
S
TAQ
G
F
N
G
H
LY
G
DE
V
FWIP
K
F
TR
L
H
E
VAS
A
MA
TH
N
K
Y
R
T
TYFSTPS
AK
TH
Q
AYP
V
W
T
G
E
A
W
RGDD
-
P
K
R
K
G
V
K
F
PNES
EM
CQ
-
G
I
LC
P
D
QI
WR
Y
I
I
T
M
EDA
I
E
GG
L
G
A
L
V
DI
E
R
LR
N
K
Y
S
P
TA
F
A
M
L
Y
MC
Q
FVD
S
K
D
A
VF
K
F
S
A
L
V
G
C
E
VD
-R
A
T
W
G
D
F
D
LT
A
T
RPFG
N
R
E
VW
A
G
F
DP
---
S
R
S
GD
NS
TF
V
LI
APP
IED
G
E
R
FR
V
L
AVW
QWQG
F
N
F
SW
QA
DQ
I
KQ
L
M
R
RF
N
I
T
YIGID
T
T
-
G
I
G
K
GVY
DL
V
S
K
F
A
P
RE
A
T
PIL
Y
S
V
ES
K
N
R
LV
M
K
M
I
D
V
V
E
R
K
R
I
E
W
AKDAVDET
N
KER
V
E
I
PA
SFMAIR
R
TT
T
N
SG
NAL
T
F
V
A
E
RS
D
ATG
HAD
V
F
F
A
IS
HA
V
I
NEP
I
D
H
E
fig|340185.3.peg.1234
Escherichia coli E22 (122-590/603)
G
E
PE
-------------
ER
K
R
R
Y
K
KN
D
V
S
GITP
E
M
L
D
TWA
R
E
HL
F
E
YQ
L
H
CR
E
H
-----
-
KGE
DW
R
F
ILKSRQ
V
G
M
T
Y
YFA
W
EA
FE
D
A
V
I
TG
------
D
NQ
V
F
F
SAS
R
S
Q
S
E
I
F
R
E
YI
V
Q
I
A
Q
NHFG
V
T
L
T
-
G
KN
I
R
L
-
S
NGA
I
L
R
FL
S
TNA
S
TAQ
G
F
N
G
H
LY
G
DE
V
FWIP
K
F
TR
L
H
E
VAS
A
MA
TH
N
K
Y
R
T
TYFSTPS
AK
TH
Q
AYP
V
W
T
G
E
A
W
RGDD
-
P
K
R
K
G
V
A
F
PTES
EM
RQ
-
G
I
LC
P
D
QI
WR
Y
I
I
T
M
EDA
I
E
GG
L
G
A
L
V
DI
E
R
LR
N
K
Y
S
P
TA
F
A
M
L
Y
MC
Q
FVD
S
K
D
A
VF
K
F
S
A
L
V
G
C
E
VD
-R
A
T
W
G
D
F
D
LT
A
A
RPFG
N
R
E
VW
A
G
F
DP
---
S
R
S
GD
NS
TF
V
LI
APP
IED
G
E
R
FR
V
L
AVW
QWQG
F
N
F
SW
QA
DQ
I
KQ
L
M
R
RF
N
I
T
YIGID
T
T
-
G
I
G
K
GVY
DL
V
S
K
F
A
P
RE
A
T
PIL
Y
S
V
ES
K
N
R
LV
M
K
M
I
D
V
V
E
R
K
R
I
E
W
AKDAVDET
N
KER
V
E
I
PA
SFMAIR
R
TT
T
N
SG
NAL
T
F
V
A
E
RS
D
ATG
HAD
V
F
F
A
IS
HA
V
I
NEP
I
D
H
E
fig|340185.4.peg.1301
Escherichia coli E22 (122-590/603)
G
E
PE
-------------
ER
K
R
R
Y
K
KN
D
V
S
GITP
E
M
L
D
TWA
R
E
HL
F
E
YQ
L
H
CR
E
H
-----
-
KGE
DW
R
F
ILKSRQ
V
G
M
T
Y
YFA
W
EA
FE
D
A
V
I
TG
------
D
NQ
V
F
F
SAS
R
S
Q
S
E
I
F
R
E
YI
V
Q
I
A
Q
NHFG
V
T
L
T
-
G
KN
I
R
L
-
S
NGA
I
L
R
FL
S
TNA
S
TAQ
G
F
N
G
H
LY
G
DE
V
FWIP
K
F
TR
L
H
E
VAS
A
MA
TH
N
K
Y
R
T
TYFSTPS
AK
TH
Q
AYP
V
W
T
G
E
A
W
RGDD
-
P
K
R
K
G
V
A
F
PTES
EM
RQ
-
G
I
LC
P
D
QI
WR
Y
I
I
T
M
EDA
I
E
GG
L
G
A
L
V
DI
E
R
LR
N
K
Y
S
P
TA
F
A
M
L
Y
MC
Q
FVD
S
K
D
A
VF
K
F
S
A
L
V
G
C
E
VD
-R
A
T
W
G
D
F
D
LT
A
A
RPFG
N
R
E
VW
A
G
F
DP
---
S
R
S
GD
NS
TF
V
LI
APP
IED
G
E
R
FR
V
L
AVW
QWQG
F
N
F
SW
QA
DQ
I
KQ
L
M
R
RF
N
I
T
YIGID
T
T
-
G
I
G
K
GVY
DL
V
S
K
F
A
P
RE
A
T
PIL
Y
S
V
ES
K
N
R
LV
M
K
M
I
D
V
V
E
R
K
R
I
E
W
AKDAVDET
N
KER
V
E
I
PA
SFMAIR
R
TT
T
N
SG
NAL
T
F
V
A
E
RS
D
ATG
HAD
V
F
F
A
IS
HA
V
I
NEP
I
D
H
E
fig|358709.5.peg.798
Escherichia coli 101-1 (125-580/595)
GA
GK
KE
-------------
R
P
R
---
K
T
N
D
V
S
GLTA
E
GF
E
PFT
K
K
-L
F
A
YQ
L
RLR
E
N
-----
-
KFR
R
V
R
N
L
LKSRQIGAT
Y
YFA
F
EA
FE
D
A
V
L
TG
------
DT
QIFLSASK
R
QA
E
VF
R
T
YI
V
K
I
A
Q
T
E
FG
I
P
I
K
-
G
N
P
V
K
L
-
S
N
L
A
E
L
Y
FL
A
TN
S
N
TAQS
N
S
G
H
LY
I
DE
Y
L
WIP
G
F
R
R
L
N
E
VASGMA
TH
K
H
W
R
I
TYFSTPS
S
K
TH
Q
G
YPFWSG
D
E
W
R
K
G
D
-
P
K
R
K
G
V
E
F
PSFD
EL
RD
G
G
RE
C
P
DGQWR
Y
V
VT
L
EDA
I
A
GG
F
N
-
L
A
DI
N
E
LR
E
R
Y
N
E
TA
F
N
M
L
F
MC
V
FVDD
K
E
SVF
K
F
D
D
L
V
R
C
G
VD
-V
S
T
W
E
D
F
H
P
EE
P
M
PFG
N
R
E
VW
G
G
F
DP
---
A
R
S
GD
N
A
TF
VV
L
APP
L
V
SAE
R
FR
V
LE
K
H
H
W
R
S
M
S
F
QF
M
A
ER
I
RS
I
K
A
R
YN
M
T
F
IGID
V
T
-
G
L
G
Y
GV
F
EL
V
Q
G
F
ARRETV
AIH
Y
S
V
ES
K
N
R
LV
M
K
M
L
D
L
I
Y
A
N
R
I
E
W
--------
D
EEA
TDI
PA
SF
L
AIR
Q
ES
T
N
SG
NKV
T
F
T
A
E
RSE
K
TG
HAD
I
F
F
A
IA
HA
A
S
NEPL
Consen1
Primary consensus
MAtGK
---------------
ggRrkp
KN
FtdEqIekLeeif
s
f
yQrhWy
a
-----
g
RiR
iLKSRQIGATfYFarEALl
AL
tg
------
rNQIFLSASk
QAyvFk
yIi
fA
-
eVdVeLk
-
GDpivL
-
NgA
L
FLGTna
tAQSy
GnlY
DE
FWip
FqeLRKVAsgMA
s
lR
TYFSTPStltH
AYpfWsG
lfNrgr
-
s
akrv
idvsh
La
GLlCaDgqwRQIVTiEDav
gGc
-
lfDidqlr
Ens
Def
NL
MCEFVdd
aSvFpl
eLq
CmVD
e
W
Dw
pfA
rPfG
RpVWIGYDp
s
nGDSagcvVvaPPaVpGGkFRilErhqwqGmdF
QA
IeklT
kYNVeyIGID
T
-
G
G
gVy
Vk
FfP
-
Aar
ytp
K
alVLKa
diir
grlEy
--------
D
tdi
sFmAiRk
T
sG
TYEasRseeaSHaDLAWATMhAl
NEPl
ge
nprtstmefF
Consen2
Secondary consensus
kp
aqk
sp
a
aa
rqki
e
e
h
lg
sltlcre
n
l
w
sq
i
ddvaqpyqh
r
q
r
i
q
a
l
e
d
tg
kmi
g
s
ss
s
h
df
vs
av
ga
k
w
sea
ay
n
rw
ekka
h
kq
fsldw
h
i
p
rty
vl
h
w
ht
leeik
yt
dy
re
e
a
nf
i
i
g
d
al
n
m
e
a
t
r
gavs
lv
v
a
r
tv
trrv
le
ef
th
g
a
f
r
y
vi
fnl
sm
m
qvms
rcw
f
rel
a
n
v
r
g
td
argi
g
l
v
i
ag
telftvile
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character