fig|1040638.4.peg.3408
Escherichia coli O104:H4 str. LB226692
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
RASTLKSWTSRLQV
fig|6666666.5357.peg.3124
Escherichia coli TY-2482 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|216592.1.peg.3148
Escherichia coli 042 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|216592.3.peg.2683
Escherichia coli 042 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|358709.5.peg.827
Escherichia coli 101-1 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|670888.3.peg.3950
Escherichia coli 1827-70 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|670897.3.peg.3301
Escherichia coli 2362-75 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|362663.8.peg.2389
Escherichia coli 536 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|362663.9.peg.2394
Escherichia coli 536 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|344610.3.peg.286
Escherichia coli 53638 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|344610.7.peg.3996
Escherichia coli 53638 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|585055.6.peg.2604
Escherichia coli 55989 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|585055.8.peg.2610
Escherichia coli 55989 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|525281.3.peg.4132
Escherichia coli 83972 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|655817.3.peg.2776
Escherichia coli ABU 83972 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|405955.13.peg.2548
Escherichia coli APEC O1 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|405955.9.peg.2094
Escherichia coli APEC O1 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|481805.3.peg.1422
Escherichia coli ATCC 8739 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|481805.6.peg.1420
Escherichia coli ATCC 8739 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|413997.3.peg.2349
Escherichia coli B str. REL606 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|550672.3.peg.2038
Escherichia coli B088 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|344601.3.peg.2917
Escherichia coli B171 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|344601.5.peg.3040
Escherichia coli B171 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|550677.3.peg.1872
Escherichia coli B354 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|340184.3.peg.597
Escherichia coli B7A (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|340184.6.peg.629
Escherichia coli B7A (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|511693.5.peg.2361
Escherichia coli BL21 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|469008.4.peg.1374
Escherichia coli BL21(DE3) (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|595496.3.peg.2301
Escherichia coli BW2952 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|199310.1.peg.2794
Escherichia coli CFT073 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|199310.4.peg.2706
Escherichia coli CFT073 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|536056.3.peg.1401
Escherichia coli DH1 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|340186.3.peg.2910
Escherichia coli E110019 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|340186.5.peg.3026
Escherichia coli E110019 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|340185.3.peg.751
Escherichia coli E22 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|340185.4.peg.793
Escherichia coli E22 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|216593.1.peg.2408
Escherichia coli E2348/69 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|562.375.peg.3315
Escherichia coli EC4100B (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|585397.7.peg.2795
Escherichia coli ED1a (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|585397.9.peg.2792
Escherichia coli ED1a (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|316401.4.peg.2812
Escherichia coli ETEC H10407 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|340197.3.peg.389
Escherichia coli F11 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|340197.5.peg.399
Escherichia coli F11 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|656379.3.peg.2865
Escherichia coli FVEC1302 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|656380.3.peg.2423
Escherichia coli FVEC1412 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|656393.3.peg.3358
Escherichia coli H299 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|656408.3.peg.2570
Escherichia coli H591 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|656414.3.peg.2711
Escherichia coli H736 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|331112.3.peg.2322
Escherichia coli HS (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|331112.6.peg.2426
Escherichia coli HS (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|585034.4.peg.2367
Escherichia coli IAI1 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|585034.5.peg.2365
Escherichia coli IAI1 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|585057.4.peg.2573
Escherichia coli IAI39 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|585057.6.peg.2576
Escherichia coli IAI39 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|714962.3.peg.2655
Escherichia coli IHE3034 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|83333.1.peg.2297
Escherichia coli K12 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|595495.4.peg.116
Escherichia coli KO11 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|656417.3.peg.3003
Escherichia coli M605 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|679207.4.peg.3036
Escherichia coli MS 107-1 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|749538.3.peg.1944
Escherichia coli MS 116-1 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|679206.4.peg.1973
Escherichia coli MS 119-7 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|679204.3.peg.358
Escherichia coli MS 145-7 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|749540.3.peg.3916
Escherichia coli MS 146-1 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|749544.3.peg.2145
Escherichia coli MS 175-1 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|749545.3.peg.318
Escherichia coli MS 182-1 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|749546.3.peg.2759
Escherichia coli MS 185-1 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|749548.3.peg.1868
Escherichia coli MS 196-1 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|749549.3.peg.1234
Escherichia coli MS 198-1 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|749550.3.peg.2866
Escherichia coli MS 200-1 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|749527.3.peg.1664
Escherichia coli MS 21-1 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|749528.3.peg.2671
Escherichia coli MS 45-1 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|749531.3.peg.3540
Escherichia coli MS 69-1 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|749532.3.peg.3097
Escherichia coli MS 78-1 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|753642.3.peg.2759
Escherichia coli NC101 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|585395.4.peg.2919
Escherichia coli O103:H2 str. 12009 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|585396.4.peg.3165
Escherichia coli O111:H- str. 11128 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|574521.7.peg.2529
Escherichia coli O127:H6 str. E2348/69 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|573235.3.peg.3382
Escherichia coli O26:H11 str. 11368 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|685038.3.peg.2388
Escherichia coli O83:H1 str. NRG 857C (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|637912.3.peg.4346
Escherichia coli OP50 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|585035.6.peg.2454
Escherichia coli S88 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|409438.11.peg.2795
Escherichia coli SE11 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|431946.3.peg.2299
Escherichia coli SE15 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|439855.10.peg.2646
Escherichia coli SMS-3-5 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|656437.3.peg.2610
Escherichia coli TA143 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|656440.3.peg.2395
Escherichia coli TA206 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|656443.3.peg.3033
Escherichia coli TA271 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|656444.3.peg.3328
Escherichia coli TA280 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|869729.3.peg.1102
Escherichia coli UM146 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|585056.7.peg.2846
Escherichia coli UMN026 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|364106.7.peg.2634
Escherichia coli UTI89 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|364106.8.peg.2634
Escherichia coli UTI89 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|566546.3.peg.1315
Escherichia coli W (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|566546.4.peg.2496
Escherichia coli W (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|316407.3.peg.2259
Escherichia coli W3110 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|316385.5.peg.2454
Escherichia coli str. K-12 substr. DH10B (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|316385.7.peg.2511
Escherichia coli str. K-12 substr. DH10B (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|511145.12.peg.2419
Escherichia coli str. K-12 substr. MG1655 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|511145.6.peg.2403
Escherichia coli str. K-12 substr. MG1655 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
KM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|562.371.peg.5191
Escherichia coli 1044A (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|562.373.peg.4081
Escherichia coli 1125A (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|562.372.peg.5437
Escherichia coli 1212A (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|562.374.peg.3479
Escherichia coli 536A (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|331111.12.peg.2902
Escherichia coli E24377A (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|331111.3.peg.354
Escherichia coli E24377A (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|656419.3.peg.3100
Escherichia coli M718 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|749537.3.peg.2176
Escherichia coli MS 115-1 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|679205.4.peg.1737
Escherichia coli MS 124-1 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|749547.3.peg.830
Escherichia coli MS 187-1 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|749533.3.peg.1764
Escherichia coli MS 84-1 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|83334.1.peg.3204
Escherichia coli O157:H7 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|444454.5.peg.2140
Escherichia coli O157:H7 str. EC4024 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|444449.5.peg.1606
Escherichia coli O157:H7 str. EC4042 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|444448.5.peg.362
Escherichia coli O157:H7 str. EC4045 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|444453.5.peg.1708
Escherichia coli O157:H7 str. EC4076 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|444452.5.peg.1276
Escherichia coli O157:H7 str. EC4113 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|444450.8.peg.3452
Escherichia coli O157:H7 str. EC4115 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|444451.5.peg.673
Escherichia coli O157:H7 str. EC4196 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|444447.5.peg.497
Escherichia coli O157:H7 str. EC4206 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|478004.5.peg.1872
Escherichia coli O157:H7 str. EC4401 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|478005.5.peg.1989
Escherichia coli O157:H7 str. EC4486 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|478006.5.peg.1735
Escherichia coli O157:H7 str. EC4501 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|478007.5.peg.1323
Escherichia coli O157:H7 str. EC508 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|478008.5.peg.2483
Escherichia coli O157:H7 str. EC869 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|637388.3.peg.259
Escherichia coli O157:H7 str. FRIK2000 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|570506.3.peg.5074
Escherichia coli O157:H7 str. FRIK966 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|386585.9.peg.3348
Escherichia coli O157:H7 str. Sakai (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|544404.4.peg.3255
Escherichia coli O157:H7 str. TW14359 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|502346.5.peg.4165
Escherichia coli O157:H7 str. TW14588 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|701177.3.peg.2893
Escherichia coli O55:H7 str. CB9615 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|562.376.peg.4253
Escherichia coli WV_060327 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|550676.3.peg.1544
Escherichia coli B185 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SAEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKA
V
G
P
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VFGD
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|155864.1.peg.3205
Escherichia coli O157:H7 EDL933 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKX
V
G
X
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VF
X
D
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|155864.8.peg.3104
Escherichia coli O157:H7 EDL933 (1-356/406)
MKR
A
VITGLG
I
VS
SI
GNN
Q
Q
E
V
L
A
S
L
RE
G
-
RSGI
TFSQ
E
LKD
-
SG
MR
S
HVW
G
N
VK
-
L
DTTGL
I
D
RK
VV
R
F
M
S
DASI
-
Y
AFL
S
M
EQAI
A
DAGL
SPEAYQ
NN
P
R
V
G
L
I
A
GSG
-
GG
S
P
RFQ
V
F
G
A
D
A
M
R
G
PR
G
LKX
V
G
X
YV
V
TKA
M
A
S
G
V
----
S
AC
L
ATP
F
KIH
G
VN
Y
SISSAC
AT
S
A
H
C
IGNA
V
E
Q
I
QL
G
K
QD
IVF
AGG
G
EELC
WEM
A
C
-
E
FDA
MG
ALST
K
Y
ND
T
PE
K
ASR
T
YD
AH
RDGFVI
A
G
G
G
GM
V
V
V
EELEHA
L
ARGA
H
IYAEIVGYG
A
T
SD
G
A
D
M
V
A
P
--
S
GEGA
VR
CM
QM
AM
H-
-
GV
D
-
TP
IDY
L
N
S
HGTSTP
V
GD
V
K
E
LA
A
IRE
VF
X
D
KS
P
--
A
I
S
A
TK
A
MTGH
S
LGAAG
V
Q
EAIYSLLMLEHGFIA
fig|656440.3.peg.1009
Escherichia coli TA206 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|344610.7.peg.549
Escherichia coli 53638 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKA
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|481805.3.peg.2692
Escherichia coli ATCC 8739 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKA
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|481805.6.peg.2679
Escherichia coli ATCC 8739 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKA
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|331112.3.peg.1134
Escherichia coli HS (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKA
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|331112.6.peg.1183
Escherichia coli HS (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKA
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|1040638.4.peg.4419
Escherichia coli O104:H4 str. LB226692 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|6666666.5357.peg.1311
Escherichia coli TY-2482 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|216592.1.peg.1518
Escherichia coli 042 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|216592.3.peg.1211
Escherichia coli 042 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|562.371.peg.4064
Escherichia coli 1044A (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|562.373.peg.4837
Escherichia coli 1125A (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|562.372.peg.555
Escherichia coli 1212A (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|670888.3.peg.1723
Escherichia coli 1827-70 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|670897.3.peg.4480
Escherichia coli 2362-75 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|362663.8.peg.1107
Escherichia coli 536 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|362663.9.peg.1107
Escherichia coli 536 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|562.374.peg.1612
Escherichia coli 536A (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|585055.6.peg.1238
Escherichia coli 55989 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|585055.8.peg.1237
Escherichia coli 55989 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|525281.3.peg.381
Escherichia coli 83972 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|655817.3.peg.1382
Escherichia coli ABU 83972 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|405955.13.peg.1098
Escherichia coli APEC O1 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|405955.9.peg.922
Escherichia coli APEC O1 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|413997.3.peg.1149
Escherichia coli B str. REL606 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|550676.3.peg.592
Escherichia coli B185 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|550677.3.peg.2538
Escherichia coli B354 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|511693.5.peg.1178
Escherichia coli BL21 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|469008.4.peg.2587
Escherichia coli BL21(DE3) (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|595496.3.peg.1039
Escherichia coli BW2952 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|199310.1.peg.1318
Escherichia coli CFT073 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|199310.4.peg.1296
Escherichia coli CFT073 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|536056.3.peg.2687
Escherichia coli DH1 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|340185.3.peg.5182
Escherichia coli E22 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|340185.4.peg.5494
Escherichia coli E22 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|216593.1.peg.924
Escherichia coli E2348/69 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|331111.12.peg.1505
Escherichia coli E24377A (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|331111.3.peg.3692
Escherichia coli E24377A (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|562.375.peg.5043
Escherichia coli EC4100B (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|585397.7.peg.1249
Escherichia coli ED1a (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|316401.4.peg.1339
Escherichia coli ETEC H10407 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|340197.3.peg.4782
Escherichia coli F11 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|340197.5.peg.4969
Escherichia coli F11 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|656379.3.peg.1938
Escherichia coli FVEC1302 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|656380.3.peg.1769
Escherichia coli FVEC1412 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|656393.3.peg.1869
Escherichia coli H299 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|656408.3.peg.1170
Escherichia coli H591 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|656414.3.peg.1337
Escherichia coli H736 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|585034.4.peg.1123
Escherichia coli IAI1 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|585034.5.peg.1120
Escherichia coli IAI1 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|585057.4.peg.2147
Escherichia coli IAI39 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|585057.6.peg.2147
Escherichia coli IAI39 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|714962.3.peg.1225
Escherichia coli IHE3034 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|83333.1.peg.1080
Escherichia coli K12 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|595495.4.peg.1840
Escherichia coli KO11 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|656417.3.peg.1334
Escherichia coli M605 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|656419.3.peg.1439
Escherichia coli M718 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|679207.4.peg.1809
Escherichia coli MS 107-1 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|749537.3.peg.2355
Escherichia coli MS 115-1 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|749538.3.peg.2085
Escherichia coli MS 116-1 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|679206.4.peg.897
Escherichia coli MS 119-7 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|679205.4.peg.4136
Escherichia coli MS 124-1 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|679204.3.peg.3650
Escherichia coli MS 145-7 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|749540.3.peg.1120
Escherichia coli MS 146-1 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|749544.3.peg.1999
Escherichia coli MS 175-1 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|749545.3.peg.812
Escherichia coli MS 182-1 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|749546.3.peg.4801
Escherichia coli MS 185-1 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|749547.3.peg.694
Escherichia coli MS 187-1 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|749549.3.peg.3489
Escherichia coli MS 198-1 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|749550.3.peg.2164
Escherichia coli MS 200-1 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|749528.3.peg.738
Escherichia coli MS 45-1 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|749531.3.peg.3019
Escherichia coli MS 69-1 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|749532.3.peg.3334
Escherichia coli MS 78-1 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|749533.3.peg.623
Escherichia coli MS 84-1 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|753642.3.peg.2217
Escherichia coli NC101 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|585395.4.peg.1201
Escherichia coli O103:H2 str. 12009 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|585396.4.peg.1429
Escherichia coli O111:H- str. 11128 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|574521.7.peg.1219
Escherichia coli O127:H6 str. E2348/69 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|83334.1.peg.1521
Escherichia coli O157:H7 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|155864.1.peg.1537
Escherichia coli O157:H7 EDL933 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|155864.8.peg.1318
Escherichia coli O157:H7 EDL933 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|444454.5.peg.5962
Escherichia coli O157:H7 str. EC4024 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|444449.5.peg.4819
Escherichia coli O157:H7 str. EC4042 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|444448.5.peg.4083
Escherichia coli O157:H7 str. EC4045 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|444453.5.peg.4896
Escherichia coli O157:H7 str. EC4076 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|444450.8.peg.1544
Escherichia coli O157:H7 str. EC4115 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|444447.5.peg.4322
Escherichia coli O157:H7 str. EC4206 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|478005.5.peg.5469
Escherichia coli O157:H7 str. EC4486 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|478008.5.peg.5604
Escherichia coli O157:H7 str. EC869 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|637388.3.peg.4086
Escherichia coli O157:H7 str. FRIK2000 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|570506.3.peg.2089
Escherichia coli O157:H7 str. FRIK966 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|544404.4.peg.1407
Escherichia coli O157:H7 str. TW14359 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|502346.5.peg.2813
Escherichia coli O157:H7 str. TW14588 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|573235.3.peg.1461
Escherichia coli O26:H11 str. 11368 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|701177.3.peg.1346
Escherichia coli O55:H7 str. CB9615 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|685038.3.peg.1063
Escherichia coli O83:H1 str. NRG 857C (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|585035.6.peg.1115
Escherichia coli S88 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|409438.11.peg.1294
Escherichia coli SE11 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|431946.3.peg.1043
Escherichia coli SE15 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|656437.3.peg.1239
Escherichia coli TA143 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|656443.3.peg.1425
Escherichia coli TA271 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|656444.3.peg.1741
Escherichia coli TA280 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|869729.3.peg.2526
Escherichia coli UM146 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|566546.4.peg.1198
Escherichia coli W (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|316407.3.peg.1057
Escherichia coli W3110 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|316385.7.peg.1191
Escherichia coli str. K-12 substr. DH10B (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|511145.12.peg.1138
Escherichia coli str. K-12 substr. MG1655 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|511145.6.peg.1130
Escherichia coli str. K-12 substr. MG1655 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|364106.7.peg.1298
Escherichia coli UTI89 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
R
D
A
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|364106.8.peg.1297
Escherichia coli UTI89 (4-358/413)
R
RVV
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
R
D
A
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|749548.3.peg.5119
Escherichia coli MS 196-1 (4-358/413)
R
Q
E
I
V
TGLG
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|444451.5.peg.5634
Escherichia coli O157:H7 str. EC4196 (1-346/401)
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
R
A
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|585397.9.peg.1245
Escherichia coli ED1a (1-346/401)
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|749527.3.peg.3340
Escherichia coli MS 21-1 (1-346/401)
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|386585.9.peg.1573
Escherichia coli O157:H7 str. Sakai (1-346/401)
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|439855.10.peg.2190
Escherichia coli SMS-3-5 (1-346/401)
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|585056.7.peg.1475
Escherichia coli UMN026 (1-346/401)
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|566546.3.peg.401
Escherichia coli W (1-346/401)
M
L
S
PV
GN
T
V
E
S
T
W
K
A
LLAG
-
Q
SGI
SLID
H
FDT
-
S
A
YA
T
KFA
G
L
VKDF
NCEDI
I
S
RK
EQ
R
K
M
-
DA
F
I
Q
Y
GIV
A
G
V
QA
M
Q
D
S
GL
EITE-E
N
A
T
R
I
G
A
A
I
GSG
I
GG
L
G
LIE
E
N
H
T
S
LM
N
G
--
G
PRK
I
S
P
FF
V
PST
I
V
N
M
V
----
A
GH
L
TIM
Y
GLRG
PS
ISI
AT
ACTS
G
V
H
N
IG
H
A
A
R
I
I
AY
G
D
A
DVMVAGGAE
KAS
TPL
G
V
G
G
F
G
A
AR
ALST
R
-
ND
N
P
Q
A
ASRP
W
D
KE
RDGFV
L
G
D
GAGMLVLEE
Y
EHAK
K
RGA
K
IYAE
L
VG
F
G
M
SSDA
Y
HMT
S
P
PE
N
G
A
GA
AL
A
M
AN
A
L
RD
AG
I
E
A
SQ
I
G
YVNAHGTSTP
A
GD
K
AE
AQ
A
VKT
I
FG
E
AA
SRV
L
VSSTKSMTGH
L
LGAAGA
V
E
S
IYS
I
L
A
L
fig|656419.3.peg.4468
Escherichia coli M718 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
S
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|525281.3.peg.1915
Escherichia coli 83972 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
VSS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|655817.3.peg.1132
Escherichia coli ABU 83972 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
VSS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|199310.1.peg.1148
Escherichia coli CFT073 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
VSS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|199310.4.peg.1126
Escherichia coli CFT073 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
VSS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|749528.3.peg.368
Escherichia coli MS 45-1 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
VSS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|216592.1.peg.719
Escherichia coli 042 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EK
SL
KI
AG
L
S
A
SD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|216592.3.peg.3898
Escherichia coli 042 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EK
SL
KI
AG
L
S
A
SD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|656379.3.peg.4771
Escherichia coli FVEC1302 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EK
SL
KI
AG
L
S
A
SD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|656380.3.peg.4561
Escherichia coli FVEC1412 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EK
SL
KI
AG
L
S
A
SD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|585056.7.peg.4129
Escherichia coli UMN026 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EK
SL
KI
AG
L
S
A
SD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|562.371.peg.3362
Escherichia coli 1044A (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|562.373.peg.1487
Escherichia coli 1125A (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|562.372.peg.4244
Escherichia coli 1212A (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|562.374.peg.5073
Escherichia coli 536A (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|550676.3.peg.3626
Escherichia coli B185 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|316401.4.peg.3607
Escherichia coli ETEC H10407 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|679205.4.peg.5243
Escherichia coli MS 124-1 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|749533.3.peg.1982
Escherichia coli MS 84-1 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|753642.3.peg.69
Escherichia coli NC101 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|83334.1.peg.4311
Escherichia coli O157:H7 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|155864.1.peg.4348
Escherichia coli O157:H7 EDL933 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|155864.8.peg.4292
Escherichia coli O157:H7 EDL933 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|444454.5.peg.3421
Escherichia coli O157:H7 str. EC4024 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|444449.5.peg.2876
Escherichia coli O157:H7 str. EC4042 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|444448.5.peg.1628
Escherichia coli O157:H7 str. EC4045 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|444453.5.peg.1160
Escherichia coli O157:H7 str. EC4076 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|444452.5.peg.182
Escherichia coli O157:H7 str. EC4113 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|444450.8.peg.4710
Escherichia coli O157:H7 str. EC4115 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|444451.5.peg.356
Escherichia coli O157:H7 str. EC4196 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|444447.5.peg.1791
Escherichia coli O157:H7 str. EC4206 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|478004.5.peg.186
Escherichia coli O157:H7 str. EC4401 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|478005.5.peg.149
Escherichia coli O157:H7 str. EC4486 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|478006.5.peg.151
Escherichia coli O157:H7 str. EC4501 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|478007.5.peg.159
Escherichia coli O157:H7 str. EC508 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|478008.5.peg.681
Escherichia coli O157:H7 str. EC869 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|637388.3.peg.1872
Escherichia coli O157:H7 str. FRIK2000 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|570506.3.peg.148
Escherichia coli O157:H7 str. FRIK966 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|386585.9.peg.4534
Escherichia coli O157:H7 str. Sakai (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|544404.4.peg.4520
Escherichia coli O157:H7 str. TW14359 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|502346.5.peg.2309
Escherichia coli O157:H7 str. TW14588 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|701177.3.peg.4213
Escherichia coli O55:H7 str. CB9615 (3-359/409)
R
RVVITG
M
G
G
V
T
AF
G
E
N
W
Q
D
V
S
A
R
LLA
Y
-
E
NAV
RKMP
E
WQV
YD
G
LH
T
LLG
A
P
V
D
DF
TLPEH
Y
T
RK
RI
R
A
M
G
RV
S
-
QM
STR
A
S
E
L
A
L
E
Q
AGL
IGDPIL
T
S
G
E
T
G
I
A
Y
GS
S
T
G
S
T
G
PVS
EF
A
T
M
L
T
E
K
--
H
TNN
I
T
G
TT
Y
VQM
M
P
H
T
T
----
A
VN
T
GLF
FGLRG
RV
I
PT
SSACTS
G
S
Q
A
IG
Y
A
W
E
A
I
RH
G
Y
Q
T
VMVAGGAEELC
PSE
A
A
-
V
FD
T
LF
A
T
S
Q
H
-
ND
A
P
K
T
TPS
P
F
D
EN
RDG
L
VIG
E
GAG
T
L
I
LEELEHAKARGA
T
IY
G
EIVG
FA
T
N
C
DAAH
I
T
Q
P
--
Q
R
E
TM
QY
CM
EQ
SL
KI
AG
L
S
A
QD
I
G
Y
I
S
AHGT
A
T
D
R
GD
M
AE
SL
A
TAT
IY
GD
NV
P
--
-
L
SS
L
KS
YF
GH
T
LGA
C
GA
L
EA
WM
SL
Q
M
MRE
G
WF
A
fig|656419.3.peg.1359
Escherichia coli M718 (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
G
V
ADSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
DD
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
L
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|562.371.peg.1564
Escherichia coli 1044A (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
G
V
KDSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
ED
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
V
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|562.373.peg.698
Escherichia coli 1125A (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
G
V
KDSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
ED
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
V
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|562.372.peg.4493
Escherichia coli 1212A (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
G
V
KDSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
ED
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
V
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|562.374.peg.1516
Escherichia coli 536A (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
G
V
KDSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
ED
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
V
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|550676.3.peg.517
Escherichia coli B185 (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
G
V
KDSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
ED
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
V
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|83334.1.peg.1346
Escherichia coli O157:H7 (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
G
V
KDSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
ED
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
V
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|155864.1.peg.1361
Escherichia coli O157:H7 EDL933 (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
G
V
KDSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
ED
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
V
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|155864.8.peg.5487
Escherichia coli O157:H7 EDL933 (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
G
V
KDSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
ED
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
V
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|444454.5.peg.5785
Escherichia coli O157:H7 str. EC4024 (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
G
V
KDSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
ED
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
V
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|444449.5.peg.4639
Escherichia coli O157:H7 str. EC4042 (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
G
V
KDSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
ED
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
V
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|444448.5.peg.3908
Escherichia coli O157:H7 str. EC4045 (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
G
V
KDSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
ED
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
V
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|444453.5.peg.2523
Escherichia coli O157:H7 str. EC4076 (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
G
V
KDSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
ED
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
V
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|444452.5.peg.473
Escherichia coli O157:H7 str. EC4113 (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
G
V
KDSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
ED
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
V
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|444450.8.peg.1368
Escherichia coli O157:H7 str. EC4115 (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
G
V
KDSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
ED
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
V
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|444451.5.peg.1417
Escherichia coli O157:H7 str. EC4196 (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
G
V
KDSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
ED
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
V
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|478004.5.peg.1205
Escherichia coli O157:H7 str. EC4401 (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
G
V
KDSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
ED
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
V
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|478005.5.peg.1644
Escherichia coli O157:H7 str. EC4486 (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
G
V
KDSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
ED
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
V
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|478006.5.peg.1290
Escherichia coli O157:H7 str. EC4501 (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
G
V
KDSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
ED
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
V
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|478007.5.peg.1939
Escherichia coli O157:H7 str. EC508 (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
G
V
KDSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
ED
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
V
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|478008.5.peg.3940
Escherichia coli O157:H7 str. EC869 (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
G
V
KDSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
ED
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
V
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|637388.3.peg.4190
Escherichia coli O157:H7 str. FRIK2000 (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
G
V
KDSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
ED
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
V
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|386585.9.peg.1397
Escherichia coli O157:H7 str. Sakai (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
G
V
KDSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
ED
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
V
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|544404.4.peg.1232
Escherichia coli O157:H7 str. TW14359 (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
G
V
KDSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
ED
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
V
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|502346.5.peg.2990
Escherichia coli O157:H7 str. TW14588 (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
G
V
KDSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
ED
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
V
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|701177.3.peg.1269
Escherichia coli O55:H7 str. CB9615 (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
G
V
KDSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
ED
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
V
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|444447.5.peg.4136
Escherichia coli O157:H7 str. EC4206 (6-347/852)
KRVVITGLG
I
L
S
SL
A
E
N
I
Q
D
F
R
E
A
LL
NK
-
K
N
X
V
KDSE
R
FAK
-
WF
EN
A
RAA
E
V
L
H
D
I
EYSDL
-
N
ED
VI
D
S
L
D
N
A
AL
-
W
AYK
V
G
K
D
A
L
S
Q
AGL
MDSR-D
T
L
K
E
T
G
M
I
V
G
V
S
S
A
G
T
E
AFL
PL
F
E
Q
R
M
E
D
--
-
---
-
-
-
FS
L
RKA
L
F
S
G
AFSSCC
SS
V
STL
L
GL
Q
G
GV
EL
V
AT
ACT
A
S
P
N
A
V
G
M
A
F
D
Y
I
QN
G
K
SKT
M
L
A
V
G
T
E
P
I
Y
LP-
-
-
-
T
F
AG
FY
AL
N
V
M
HP
D
T
--
-
-CT
P
F
S
GQ
-S
G
MS
IG
E
GAG
A
I
VLEE
Y
EHA
V
ARGA
T
IY
G
EI
L
S
Y
A
T
S
C
DA
F
H
E
T
G
P
DP
R
AS
GA
VQ
V
M
NK
AM
AN
AGV
T
P
EQ
IDYVNAHGT
G
T
E
A
N
D
R
I
E
TL
A
MKK
VF
A
N
HD
K
-
L
L
VSSTKS
YF
GH
N
I
GAAG
I
V
E
L
I
AC
L
AT
L
fig|550676.3.peg.3623
Escherichia coli B185 (4-333/389)
I
S
A
V
G
M
IN
AL
GNN
L
D
E
I
A
A
N
L
AR
G
VAP
G
M
RPRA
G
WLQ
-
GH
PQ
A
VLA
G
V
--
D
G
ELPLI
P
E
K
F
AA
H
R
S
R
N
NQ
I
LL
AAL
A
Q
L
Q
PQ
V
D
DA
I
AK---Y
GR
E
R
I
A
I
V
L
G
T
S
T
S
G
L
H
EGD
TH
V
N
L
R
T
H
G
--
-
LPS
T
T
W
HY
A
QQE
L
G
D
P
-
----
S
RF
L
SHW
LA
L
D
G
PA
Y
TL
S
T
AC
S
SS
A
R
A
M
I
S
G
R
R
L
I
ET
G
L
V
D
AA
I
V
GGA
D
T
L
S
-RM
P
I
N
G
F
H
S
LE
S
LS
P
T
-
--
-
--
-
LC
Q
P
F
G
RD
R
A
G
IT
IG
E
GAG
LML
L
TREPQPI
A
---
-
----
L
L
G
V
G
E
SSDA
Y
H
I
S
A
P
HP
Q
GEGA
IR
A
I
NQ
A
L
TD
A
Q
L
T
P
DD
V
G
Y
I
N
L
HGT
A
T
Q
L
N
D
Q
I
E
SM
V
VNA
L
FG
E
RV
P
--
-
C
SSTK
H
L
TGH
T
LGAAG
I
T
EA
AI
S
M
L
I
L
Q
Consen1
Primary consensus
MkRvViTGlG
vs
Gnn
q
v
a
Llag
-
rsgi
e
-
sg
t
g
Vkdf
i
RK
R
M
dasi
-
y
a
eqAi
daGL
nn
r
G
i
GSg
Gg
g
ef
t
lm
g
--
g
i
p
v
m
s
v
----
a
l
fglrG
isissACtss
h
IGnA
e
I
G
qdvmvAGGaEelc
a
-
Fda
AlSt
-
ND
Pe
asrpyD
RDGfVig
GaGmlvlEElEHAkaRGA
IYaEiVGyg
ssDaahmt
P
--
gega
cM
am
aGv
a
IdYvnaHGTsTp
GD
aE
A
vfGd
p
--
vSstKsmtGH
LGAaGa
EaiySllmlehGfiA
Consen2
Secondary consensus
r
a
v
m
lt
et
e
t
k
rey
nav
h
yda
s
a
d
-
l
y
rvf
-
qm
s
vl
qs
t
e
a
s
s
p
vn
a
at
kprh
v
g
y
i
t
s
t
ykih
yptat
atg
q
r
ativf
g
kas
g
g
gt
t
q
y
tpst
l
la
g
tviv
y
lk
g
l
fa
c
gydiv
pe
ratm
a
sl
-
-
g
ss
a
d
k
iy
e
srv
al
ayf
c
v
swm
iqamre
wf
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character