fig|478004.5.peg.1783
Escherichia coli O157:H7 str. EC4401 (1-447/812)
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQ
fig|1040638.4.peg.3321
Escherichia coli O104:H4 str. LB226692
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|670888.3.peg.4037
Escherichia coli 1827-70
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|670897.3.peg.3219
Escherichia coli 2362-75
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|362663.8.peg.2302
Escherichia coli 536
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|362663.9.peg.2307
Escherichia coli 536
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|585055.6.peg.2523
Escherichia coli 55989
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|585055.8.peg.2528
Escherichia coli 55989
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|525281.3.peg.4048
Escherichia coli 83972
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|655817.3.peg.2691
Escherichia coli ABU 83972
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|413997.3.peg.2262
Escherichia coli B str. REL606
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|511693.5.peg.2275
Escherichia coli BL21
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|469008.4.peg.1461
Escherichia coli BL21(DE3)
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|199310.1.peg.2710
Escherichia coli CFT073
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|199310.4.peg.2619
Escherichia coli CFT073
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|216593.1.peg.2498
Escherichia coli E2348/69
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|331111.12.peg.2819
Escherichia coli E24377A
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|331111.3.peg.274
Escherichia coli E24377A
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|585397.7.peg.2708
Escherichia coli ED1a
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|585397.9.peg.2705
Escherichia coli ED1a
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|340197.3.peg.304
Escherichia coli F11
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|340197.5.peg.313
Escherichia coli F11
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|656393.3.peg.3274
Escherichia coli H299
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|331112.3.peg.2236
Escherichia coli HS
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|331112.6.peg.2333
Escherichia coli HS
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|585034.4.peg.2285
Escherichia coli IAI1
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|585034.5.peg.2282
Escherichia coli IAI1
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|656417.3.peg.2917
Escherichia coli M605
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|679207.4.peg.3119
Escherichia coli MS 107-1
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|679206.4.peg.1889
Escherichia coli MS 119-7
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|679205.4.peg.1820
Escherichia coli MS 124-1
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|749546.3.peg.2672
Escherichia coli MS 185-1
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|749547.3.peg.3501
Escherichia coli MS 187-1
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|749550.3.peg.1692
Escherichia coli MS 200-1
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|749528.3.peg.2789
Escherichia coli MS 45-1
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|749533.3.peg.1679
Escherichia coli MS 84-1
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|753642.3.peg.2846
Escherichia coli NC101
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|585396.4.peg.3081
Escherichia coli O111:H- str. 11128
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|573235.3.peg.3299
Escherichia coli O26:H11 str. 11368
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|685038.3.peg.2303
Escherichia coli O83:H1 str. NRG 857C
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|409438.11.peg.2659
Escherichia coli SE11
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|431946.3.peg.2214
Escherichia coli SE15
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|656443.3.peg.2950
Escherichia coli TA271
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|562.376.peg.4166
Escherichia coli WV_060327
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|405955.13.peg.2462
Escherichia coli APEC O1
MLSIFKPAP
HKA
R
L
PTA
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|405955.9.peg.2014
Escherichia coli APEC O1
MLSIFKPAP
HKA
R
L
PTA
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|714962.3.peg.2521
Escherichia coli IHE3034
MLSIFKPAP
HKA
R
L
PTA
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|585035.6.peg.2367
Escherichia coli S88
MLSIFKPAP
HKA
R
L
PTA
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|869729.3.peg.1189
Escherichia coli UM146
MLSIFKPAP
HKA
R
L
PTA
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|364106.7.peg.2548
Escherichia coli UTI89
MLSIFKPAP
HKA
R
L
PTA
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|364106.8.peg.2548
Escherichia coli UTI89
MLSIFKPAP
HKA
R
L
PTA
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|358709.5.peg.693
Escherichia coli 101-1
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HC
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|344610.3.peg.3346
Escherichia coli 53638
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQ
E
RN
GG
fig|344610.7.peg.4084
Escherichia coli 53638
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQ
E
RN
GG
fig|481805.3.peg.1512
Escherichia coli ATCC 8739
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQ
E
RN
GG
fig|481805.6.peg.1506
Escherichia coli ATCC 8739
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQ
E
RN
GG
fig|595496.3.peg.2211
Escherichia coli BW2952
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQ
E
RN
GG
fig|536056.3.peg.1491
Escherichia coli DH1
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQ
E
RN
GG
fig|316401.4.peg.2714
Escherichia coli ETEC H10407
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQ
E
RN
GG
fig|83333.1.peg.2213
Escherichia coli K12
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQ
E
RN
GG
fig|749538.3.peg.2307
Escherichia coli MS 116-1
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQ
E
RN
GG
fig|749548.3.peg.3086
Escherichia coli MS 196-1
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQ
E
RN
GG
fig|316407.3.peg.2173
Escherichia coli W3110
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQ
E
RN
GG
fig|316385.7.peg.2419
Escherichia coli str. K-12 substr. DH10B
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQ
E
RN
GG
fig|511145.12.peg.2329
Escherichia coli str. K-12 substr. MG1655
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQ
E
RN
GG
fig|511145.6.peg.2313
Escherichia coli str. K-12 substr. MG1655
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQ
E
RN
GG
fig|656440.3.peg.2229
Escherichia coli TA206
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MV
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|344601.3.peg.1472
Escherichia coli B171
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|344601.5.peg.1547
Escherichia coli B171
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|340184.3.peg.1596
Escherichia coli B7A
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|340184.6.peg.1677
Escherichia coli B7A
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|340186.3.peg.1345
Escherichia coli E110019
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|340186.5.peg.1391
Escherichia coli E110019
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|340185.3.peg.668
Escherichia coli E22
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|340185.4.peg.711
Escherichia coli E22
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|562.375.peg.3230
Escherichia coli EC4100B
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|595495.4.peg.198
Escherichia coli KO11
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|679204.3.peg.272
Escherichia coli MS 145-7
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|749545.3.peg.4147
Escherichia coli MS 182-1
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|749532.3.peg.3520
Escherichia coli MS 78-1
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|585395.4.peg.2835
Escherichia coli O103:H2 str. 12009
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|566546.3.peg.1397
Escherichia coli W
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|566546.4.peg.2416
Escherichia coli W
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQKRN
GG
fig|749537.3.peg.2263
Escherichia coli MS 115-1
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|562.371.peg.5101
Escherichia coli 1044A
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|562.373.peg.3991
Escherichia coli 1125A
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|562.372.peg.5526
Escherichia coli 1212A
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|562.374.peg.3391
Escherichia coli 536A
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|550676.3.peg.1453
Escherichia coli B185
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|585057.4.peg.2479
Escherichia coli IAI39
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|585057.6.peg.2482
Escherichia coli IAI39
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|749527.3.peg.1762
Escherichia coli MS 21-1
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|749531.3.peg.3453
Escherichia coli MS 69-1
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|83334.1.peg.3120
Escherichia coli O157:H7
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|155864.1.peg.3124
Escherichia coli O157:H7 EDL933
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|155864.8.peg.3018
Escherichia coli O157:H7 EDL933
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|444454.5.peg.2051
Escherichia coli O157:H7 str. EC4024
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|444449.5.peg.1515
Escherichia coli O157:H7 str. EC4042
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|444448.5.peg.274
Escherichia coli O157:H7 str. EC4045
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|444453.5.peg.1620
Escherichia coli O157:H7 str. EC4076
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|444452.5.peg.2639
Escherichia coli O157:H7 str. EC4113
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|444450.8.peg.3364
Escherichia coli O157:H7 str. EC4115
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|444451.5.peg.762
Escherichia coli O157:H7 str. EC4196
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|444447.5.peg.408
Escherichia coli O157:H7 str. EC4206
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|478006.5.peg.1824
Escherichia coli O157:H7 str. EC4501
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|478007.5.peg.1234
Escherichia coli O157:H7 str. EC508
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|478008.5.peg.2398
Escherichia coli O157:H7 str. EC869
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|637388.3.peg.345
Escherichia coli O157:H7 str. FRIK2000
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|570506.3.peg.4988
Escherichia coli O157:H7 str. FRIK966
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|386585.9.peg.3259
Escherichia coli O157:H7 str. Sakai
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|544404.4.peg.3167
Escherichia coli O157:H7 str. TW14359
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|502346.5.peg.4254
Escherichia coli O157:H7 str. TW14588
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|701177.3.peg.2805
Escherichia coli O55:H7 str. CB9615
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|439855.10.peg.2560
Escherichia coli SMS-3-5
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|216592.1.peg.3055
Escherichia coli 042
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
N
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|216592.3.peg.2595
Escherichia coli 042
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
N
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|550677.3.peg.1788
Escherichia coli B354
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
N
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|656379.3.peg.2779
Escherichia coli FVEC1302
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
N
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|656380.3.peg.2336
Escherichia coli FVEC1412
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
N
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|749549.3.peg.1785
Escherichia coli MS 198-1
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
N
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|585056.7.peg.2759
Escherichia coli UMN026
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
N
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
Q
E
LLQKRN
GG
fig|656444.3.peg.3242
Escherichia coli TA280
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FLP
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
FY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
I
D
E
K
R
RH
Q
E
LLQKRN
GG
fig|749540.3.peg.4005
Escherichia coli MS 146-1
MLSIFKPAP
HKA
R
L
P
A
A
E
I
D
PT
Y
RR
L
RW
-----
Q
IF
L
G
I
F
F
GY
AAY
YL
V
RKNF
AL
A
MPYLVEQ-
G
F
S
RGD
LG
FALS
G
I
SI
A
YGF
S
K
FIMGSVS
D
RS
N
P
R
V
FL
L
AG
LIL
A
A
AV
ML
FM
GF
VPW
A
T
S
---
S
I
A
V
M
FVLLF
L
-----
C
G
W
FQGMG
WPP
C
GR
T
MVH
W
W
S
Q
K
E
RG
G
I
V
S
V
WN
CA
HN
V
G
---
G
GIPP
L
LF
L
L
G
MA
W
FN
D
---
--
W
HA
AL
YM
P
AFC
A
I
L
V
A
L
F
A
F
AMMR
DTP
Q
S
C
GL
PPI
EE
---
Y
K
N
D
YP
DDY
N
E
K
A
E
Q
--
E
LT
AK
QIF
MQ
YVL
P
NK
L
L
W
Y
I
AIAN
V
F
V
Y
L
L
RYGI
LD
WSPTY
----
LK
EV
K
HF
A
LD
---------
KSSW
AYF
LY
E
YA
G
IP
--
GTLL
C
GW
M
SD
KVFR
G
N
RG
ATG
V
F
FM
TL
V
T
I
AT
I
VY
WM
NP
AG
--
NP
T
--
V
DMI
C
M
I
V
IGFL
IY
GPV
M
LIG
LH
A
LE
L
A
PKKA
A
G
T
A
A
GF
T
GLFGYLGG
SV
AA
S
A
I
VG
YTV
D
------
F
F
GW
D
GGF
MV
M
IGG
S
I
LAVI
L
L
IV
V
M
IG
E
K
R
RH
E
Q
LLQ
E
RN
GG
fig|344610.3.peg.3780
Escherichia coli 53638 (14-456/467)
M
S
L
F
TEPKEIE
R
L
P
S
E
E
I
E
RL
Y
PV
L
R
Y
-----
R
VF
I
S
I
F
L
GY
MGY
Y
F
V
R
NTT
SV
L
SGVL----
H
M
S
ATE
I
G
IISC
AG
F
L
S
YG
I
S
K
FVSGLIS
D
RS
N
S
K
V
FL
S
LG
L
F
L
S
G
LV
NF
LI
G
Y
IPG
I
I
T
---
S
V
T
L
F
STMYL
L
-----
N
G
W
I
QGMG
YPP
G
AK
T
LVF
W
Y
EH
R
E
R
I
T
WAT
L
WN
LS
HN
V
G
---
G
ALAP
V
LI
G
F
S
FG
F
FG
D
SAL
DH
A
RA
A
F
IF
P
GVL
C
M
A
M
S
V
L
I
Y
FIQV
D
R
P
V
S
V
GL
PPI
EE
---
W
K
G
N
VV
S
HP
A
K
G
R
E
Q
GP
R
L
S
IP
D
I
I
RK
HII
R
N
N
K
L
I
Y
C
C
I
YGS
F
V
Y
I
L
RYGI
VS
W
A
P
K
F
----
L
S
D-
-
--
S
LD
VGGKDMGKL
ASMG
GF
S
VF
E
IG
G
V
A
--
G
M
LL
A
G
Y
LS
V
RLFR
N
S
K
P
LTN
T
L
F
L
A
L
T
I
I
LL
I
A
Y
WY
V
PS
G
--
N
E
Y
L
W
L
NYT
I
L
I
L
L
G
LA
VY
GPV
M
F
IG
LY
S
ME
L
V
PK
E
A
A
GAA
S
G
L
S
G
T
F
S
Y
I
F
G
SI
V
A
T
L
G
M
G
LVV
D
------
Y
L
GW
G
AT
F
IV
L
ILS
A
V
FAII
FT
LM
fig|344610.7.peg.319
Escherichia coli 53638 (1-443/454)
M
S
L
F
TEPKEIE
R
L
P
S
E
E
I
E
RL
Y
PV
L
R
Y
-----
R
VF
I
S
I
F
L
GY
MGY
Y
F
V
R
NTT
SV
L
SGVL----
H
M
S
ATE
I
G
IISC
AG
F
L
S
YG
I
S
K
FVSGLIS
D
RS
N
S
K
V
FL
S
LG
L
F
L
S
G
LV
NF
LI
G
Y
IPG
I
I
T
---
S
V
T
L
F
STMYL
L
-----
N
G
W
I
QGMG
YPP
G
AK
T
LVF
W
Y
EH
R
E
R
I
T
WAT
L
WN
LS
HN
V
G
---
G
ALAP
V
LI
G
F
S
FG
F
FG
D
SAL
DH
A
RA
A
F
IF
P
GVL
C
M
A
M
S
V
L
I
Y
FIQV
D
R
P
V
S
V
GL
PPI
EE
---
W
K
G
N
VV
S
HP
A
K
G
R
E
Q
GP
R
L
S
IP
D
I
I
RK
HII
R
N
N
K
L
I
Y
C
C
I
YGS
F
V
Y
I
L
RYGI
VS
W
A
P
K
F
----
L
S
D-
-
--
S
LD
VGGKDMGKL
ASMG
GF
S
VF
E
IG
G
V
A
--
G
M
LL
A
G
Y
LS
V
RLFR
N
S
K
P
LTN
T
L
F
L
A
L
T
I
I
LL
I
A
Y
WY
V
PS
G
--
N
E
Y
L
W
L
NYT
I
L
I
L
L
G
LA
VY
GPV
M
F
IG
LY
S
ME
L
V
PK
E
A
A
GAA
S
G
L
S
G
T
F
S
Y
I
F
G
SI
V
A
T
L
G
M
G
LVV
D
------
Y
L
GW
G
AT
F
IV
L
ILS
A
V
FAII
FT
LM
fig|481805.3.peg.36
Escherichia coli ATCC 8739 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
S
VY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|481805.6.peg.35
Escherichia coli ATCC 8739 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
S
VY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|749531.3.peg.327
Escherichia coli MS 69-1 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
Q
Y
--
I
YLT
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|6666666.5357.peg.672
Escherichia coli TY-2482 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|216592.1.peg.1008
Escherichia coli 042 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|216592.3.peg.4172
Escherichia coli 042 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|358709.5.peg.94
Escherichia coli 101-1 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|562.371.peg.3063
Escherichia coli 1044A (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|562.373.peg.991
Escherichia coli 1125A (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|562.372.peg.3949
Escherichia coli 1212A (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|670897.3.peg.3593
Escherichia coli 2362-75 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|362663.8.peg.3897
Escherichia coli 536 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|362663.9.peg.3912
Escherichia coli 536 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|344610.3.peg.1899
Escherichia coli 53638 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|344610.7.peg.2532
Escherichia coli 53638 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|562.374.peg.2039
Escherichia coli 536A (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|585055.6.peg.4166
Escherichia coli 55989 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|585055.8.peg.4169
Escherichia coli 55989 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|525281.3.peg.3168
Escherichia coli 83972 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|655817.3.peg.4340
Escherichia coli ABU 83972 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|405955.13.peg.4125
Escherichia coli APEC O1 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|405955.9.peg.3452
Escherichia coli APEC O1 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|413997.3.peg.3727
Escherichia coli B str. REL606 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|550672.3.peg.3736
Escherichia coli B088 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|344601.3.peg.2447
Escherichia coli B171 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|344601.5.peg.2549
Escherichia coli B171 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|550676.3.peg.3880
Escherichia coli B185 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|550677.3.peg.4253
Escherichia coli B354 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|511693.5.peg.3746
Escherichia coli BL21 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|469008.4.peg.39
Escherichia coli BL21(DE3) (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|595496.3.peg.3670
Escherichia coli BW2952 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|536056.3.peg.39
Escherichia coli DH1 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|340186.3.peg.2338
Escherichia coli E110019 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|340186.5.peg.2416
Escherichia coli E110019 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|340185.3.peg.2142
Escherichia coli E22 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|340185.4.peg.2272
Escherichia coli E22 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|216593.1.peg.4475
Escherichia coli E2348/69 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|331111.12.peg.4412
Escherichia coli E24377A (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|331111.3.peg.1813
Escherichia coli E24377A (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|562.375.peg.333
Escherichia coli EC4100B (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|585397.7.peg.4355
Escherichia coli ED1a (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|585397.9.peg.4352
Escherichia coli ED1a (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|316401.4.peg.4492
Escherichia coli ETEC H10407 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|340197.3.peg.482
Escherichia coli F11 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|340197.5.peg.497
Escherichia coli F11 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|656379.3.peg.4522
Escherichia coli FVEC1302 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|656380.3.peg.4806
Escherichia coli FVEC1412 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|656393.3.peg.4836
Escherichia coli H299 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|656408.3.peg.4122
Escherichia coli H591 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|656414.3.peg.4189
Escherichia coli H736 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|331112.3.peg.3636
Escherichia coli HS (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|331112.6.peg.3791
Escherichia coli HS (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|585034.4.peg.3759
Escherichia coli IAI1 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|585034.5.peg.3756
Escherichia coli IAI1 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|714962.3.peg.4159
Escherichia coli IHE3034 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|83333.1.peg.3603
Escherichia coli K12 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|595495.4.peg.2792
Escherichia coli KO11 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|656419.3.peg.4723
Escherichia coli M718 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|679207.4.peg.105
Escherichia coli MS 107-1 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|749537.3.peg.1269
Escherichia coli MS 115-1 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|749538.3.peg.3199
Escherichia coli MS 116-1 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|679206.4.peg.2214
Escherichia coli MS 119-7 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|679204.3.peg.2921
Escherichia coli MS 145-7 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|749540.3.peg.954
Escherichia coli MS 146-1 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|749544.3.peg.1170
Escherichia coli MS 175-1 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|749545.3.peg.3398
Escherichia coli MS 182-1 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|749546.3.peg.1447
Escherichia coli MS 185-1 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|749547.3.peg.4312
Escherichia coli MS 187-1 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|749548.3.peg.4130
Escherichia coli MS 196-1 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|749549.3.peg.1362
Escherichia coli MS 198-1 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|749550.3.peg.3393
Escherichia coli MS 200-1 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|749528.3.peg.2898
Escherichia coli MS 45-1 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|749532.3.peg.424
Escherichia coli MS 78-1 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|749533.3.peg.1139
Escherichia coli MS 84-1 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|753642.3.peg.4255
Escherichia coli NC101 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|585395.4.peg.4699
Escherichia coli O103:H2 str. 12009 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|585396.4.peg.4651
Escherichia coli O111:H- str. 11128 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|574521.7.peg.4057
Escherichia coli O127:H6 str. E2348/69 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|83334.1.peg.4573
Escherichia coli O157:H7 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|444454.5.peg.3694
Escherichia coli O157:H7 str. EC4024 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|444449.5.peg.3149
Escherichia coli O157:H7 str. EC4042 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|444448.5.peg.1905
Escherichia coli O157:H7 str. EC4045 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|444453.5.peg.1434
Escherichia coli O157:H7 str. EC4076 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|444452.5.peg.1664
Escherichia coli O157:H7 str. EC4113 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|444450.8.peg.4986
Escherichia coli O157:H7 str. EC4115 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|444451.5.peg.80
Escherichia coli O157:H7 str. EC4196 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|444447.5.peg.2068
Escherichia coli O157:H7 str. EC4206 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|478004.5.peg.461
Escherichia coli O157:H7 str. EC4401 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|478005.5.peg.398
Escherichia coli O157:H7 str. EC4486 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|478006.5.peg.446
Escherichia coli O157:H7 str. EC4501 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|478007.5.peg.1505
Escherichia coli O157:H7 str. EC508 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|478008.5.peg.968
Escherichia coli O157:H7 str. EC869 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|637388.3.peg.2924
Escherichia coli O157:H7 str. FRIK2000 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|570506.3.peg.4717
Escherichia coli O157:H7 str. FRIK966 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|386585.9.peg.4811
Escherichia coli O157:H7 str. Sakai (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|544404.4.peg.4797
Escherichia coli O157:H7 str. TW14359 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|502346.5.peg.2010
Escherichia coli O157:H7 str. TW14588 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|573235.3.peg.5063
Escherichia coli O26:H11 str. 11368 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|701177.3.peg.4480
Escherichia coli O55:H7 str. CB9615 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|685038.3.peg.3735
Escherichia coli O83:H1 str. NRG 857C (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|585035.6.peg.4020
Escherichia coli S88 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|409438.11.peg.4124
Escherichia coli SE11 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|656440.3.peg.3980
Escherichia coli TA206 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|656443.3.peg.4602
Escherichia coli TA271 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|656444.3.peg.5001
Escherichia coli TA280 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|869729.3.peg.3975
Escherichia coli UM146 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|585056.7.peg.4367
Escherichia coli UMN026 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|364106.7.peg.4126
Escherichia coli UTI89 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|364106.8.peg.4128
Escherichia coli UTI89 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|566546.3.peg.3331
Escherichia coli W (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|566546.4.peg.3923
Escherichia coli W (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|316407.3.peg.3462
Escherichia coli W3110 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|562.376.peg.2511
Escherichia coli WV_060327 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|316385.5.peg.3801
Escherichia coli str. K-12 substr. DH10B (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|316385.7.peg.3887
Escherichia coli str. K-12 substr. DH10B (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|511145.12.peg.3788
Escherichia coli str. K-12 substr. MG1655 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|511145.6.peg.3770
Escherichia coli str. K-12 substr. MG1655 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|199310.1.peg.4493
Escherichia coli CFT073 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AL
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|199310.4.peg.4307
Escherichia coli CFT073 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AL
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|585057.4.peg.4403
Escherichia coli IAI39 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
Q
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|585057.6.peg.4413
Escherichia coli IAI39 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
Q
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|656417.3.peg.4552
Escherichia coli M605 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
Q
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|749527.3.peg.3410
Escherichia coli MS 21-1 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
Q
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|439855.10.peg.4170
Escherichia coli SMS-3-5 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
Q
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|656437.3.peg.4142
Escherichia coli TA143 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
Q
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|155864.1.peg.4609
Escherichia coli O157:H7 EDL933 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
X
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|155864.8.peg.4569
Escherichia coli O157:H7 EDL933 (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
X
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|431946.3.peg.3660
Escherichia coli SE15 (6-450/459)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RKNF
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
Q
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERK
fig|340184.3.peg.904
Escherichia coli B7A (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RK
H
F
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|340184.6.peg.938
Escherichia coli B7A (6-459/463)
NQVR
K
PT
L
D
L
P
LE
VRR
K
M
W
FKPFM
Q
SY
L
V
VF
I
GY
LTM
YL
I
RK
H
F
NI
A
QNDMISTY
GLS
MTQ
LG
MIGL
GFSI
T
YG
V
G
K
TLVSYYA
D
GK
N
T
K
Q
FLP
FM
LIL
S
A
IC
ML
--
GF
SAS
M
G
S
GSV
S
L
F
L
M
IAFYA
L
-----
S
GFFQ
ST
G
GSC
S
YS
T
ITK
W
T
P
R
R
K
RG
T
F
LG
F
WN
IS
HNLG
---
G
AGAA
G
VA
L
F
G
AN
Y
LF
D
---
GH
V
IG
MF
IF
P
SII
AL
I
VG
F
I
G
L
RYGS
D
S
PES
Y
GL
GKA
EE
---
L
F
G
E
EI
SEE
D
K
E
T
ES
-
T
D
M
T
KW
QIF
VE
YVL
K
NK
V
IW
L
L
CF
ANIFLYV
V
R
I
GI
DQ
WS
TV
Y
AFQE
LK
LS
K
AV
A
IQ
---------
----
GFT
LF
E
AG
A
LV
--
GTLL
W
GWLSD
-LAN
G
R
RG
LVA
C
I
AL
A
LI
I
A
TL
GVY
QH
--
A
S
--
N
E
Y
--
I
YLA
S
L
F
A
L
GFL
VF
GP
Q
L
LIG
VA
A
VG
F
V
PKKA
I
GAA
D
G
I
K
G
T
F
A
YL
I
G
DS
F
A
K
L
G
L
G
MIA
D
GTPVFGL
T
GWAG
T
F
AA
L
DIA
AI
GCIC
LM
AI
V
A
VMEERKIRREKKIQQ
fig|550677.3.peg.1795
Escherichia coli B354 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
EE
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|439855.10.peg.2568
Escherichia coli SMS-3-5 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
EE
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
S
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|749537.3.peg.2257
Escherichia coli MS 115-1 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
V
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
M
A
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
L
V
fig|216593.1.peg.2489
Escherichia coli E2348/69 (14-430/442)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
S
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|656444.3.peg.3249
Escherichia coli TA280 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|585057.4.peg.2487
Escherichia coli IAI39 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALT
M
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
S
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|585057.6.peg.2490
Escherichia coli IAI39 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALT
M
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
S
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|670897.3.peg.3227
Escherichia coli 2362-75 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
S
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|749531.3.peg.3461
Escherichia coli MS 69-1 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
K
K
L
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
M
A
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|574521.7.peg.2449
Escherichia coli O127:H6 str. E2348/69 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
S
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|199310.1.peg.2717
Escherichia coli CFT073 (14-430/442)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
I
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
S
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|595496.3.peg.2219
Escherichia coli BW2952 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
V
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
L
R
AAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
M
A
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|536056.3.peg.1483
Escherichia coli DH1 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
V
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
L
R
AAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
M
A
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|83333.1.peg.2219
Escherichia coli K12 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
V
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
L
R
AAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
M
A
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|316407.3.peg.2179
Escherichia coli W3110 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
V
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
L
R
AAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
M
A
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|316385.5.peg.2373
Escherichia coli str. K-12 substr. DH10B (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
V
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
L
R
AAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
M
A
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|316385.7.peg.2427
Escherichia coli str. K-12 substr. DH10B (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
V
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
L
R
AAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
M
A
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|511145.12.peg.2337
Escherichia coli str. K-12 substr. MG1655 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
V
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
L
R
AAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
M
A
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|511145.6.peg.2321
Escherichia coli str. K-12 substr. MG1655 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
V
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
L
R
AAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
M
A
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|358709.5.peg.700
Escherichia coli 101-1 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
V
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
M
A
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|670888.3.peg.4030
Escherichia coli 1827-70 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
V
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
M
A
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|344610.3.peg.3354
Escherichia coli 53638 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
V
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
M
A
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|344610.7.peg.4076
Escherichia coli 53638 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
V
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
M
A
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|481805.3.peg.1504
Escherichia coli ATCC 8739 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
V
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
M
A
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|481805.6.peg.1498
Escherichia coli ATCC 8739 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
V
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
M
A
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|550676.3.peg.1461
Escherichia coli B185 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
V
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
M
A
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|316401.4.peg.2722
Escherichia coli ETEC H10407 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
V
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
M
A
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|656414.3.peg.2627
Escherichia coli H736 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
V
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
M
A
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|331112.3.peg.2243
Escherichia coli HS (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
V
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
M
A
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|331112.6.peg.2340
Escherichia coli HS (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
V
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
M
A
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|656419.3.peg.3017
Escherichia coli M718 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
V
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
M
A
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|749538.3.peg.2315
Escherichia coli MS 116-1 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
V
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
M
A
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|749540.3.peg.3997
Escherichia coli MS 146-1 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
V
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
M
A
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|749547.3.peg.3494
Escherichia coli MS 187-1 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
V
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
M
A
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|749548.3.peg.3094
Escherichia coli MS 196-1 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
V
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
M
A
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
V
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
A
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|362663.8.peg.2310
Escherichia coli 536 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
I
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
S
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|362663.9.peg.2315
Escherichia coli 536 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
I
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
S
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|525281.3.peg.4055
Escherichia coli 83972 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
I
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
S
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|655817.3.peg.2698
Escherichia coli ABU 83972 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
I
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
S
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|405955.13.peg.2470
Escherichia coli APEC O1 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
I
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
S
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|405955.9.peg.2021
Escherichia coli APEC O1 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
I
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
S
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|199310.4.peg.2626
Escherichia coli CFT073 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
I
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
S
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|340197.3.peg.311
Escherichia coli F11 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
I
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
S
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|340197.5.peg.321
Escherichia coli F11 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
I
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
S
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|714962.3.peg.2529
Escherichia coli IHE3034 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
I
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
S
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|749546.3.peg.2679
Escherichia coli MS 185-1 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
I
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
S
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|749550.3.peg.1683
Escherichia coli MS 200-1 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
I
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
S
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|749528.3.peg.2591
Escherichia coli MS 45-1 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
I
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
S
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|685038.3.peg.2311
Escherichia coli O83:H1 str. NRG 857C (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
I
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
S
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|656440.3.peg.2237
Escherichia coli TA206 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
I
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
S
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|869729.3.peg.1181
Escherichia coli UM146 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
I
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
S
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|364106.7.peg.2556
Escherichia coli UTI89 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
I
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
S
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
fig|364106.8.peg.2556
Escherichia coli UTI89 (1-417/429)
M
S
TA
L
LD
AV
V
KK
N
R
A
-----
R
LI
P
F
M
L
A
L
Y
VLA
F
L
D
R
S
N
I
GF
A
KQTYQIDT
GLS
NEA
YA
LGAG
I
F
FV
V
Y
A
F
L
G
VPANLLM
R
KL
G
A
R
T
WI
-
--
---
-
G
TT
T
L
LW
GF
LSA
A
M
A
WAD
T
E
A
K
F
LIVRT
L
LGAAE
A
GFF
P
GM
I
YLT
S
--
-
--Q
W
F
PQR
N
R
A
S
I
M
G
L
FY
MG
AP
L
ALTL
G
SPLS
G
AL
L
E
M
HG
F
MG
H
---
PG
W
FW
MF
VI
E
GLL
A
V
G
A
G
V
F
T
F
FWLD
DTPE
Q
A
RF
LSK
Q
E
KTL
L
I
N
Q
LA
SEE
Q
Q
K
V
T
S
--
R
L
S
D-
---
--
-
A
L
R
N
G
R
V
W
Q
LAI
IY
L
T
I
Q
V
A
V
YG
L
IF
FL
PT
Q
VAAL
L
-
--
-
--
-
--
---------
GTKV
GFT
AS
V
VT
AIP
WVAA
L
F
G
T
WL
IP
RYSD
K
T
GE
RRN
V
A
ALTL
L
A
A
GI
G
IG
L-
--
S
G
LLS
P
V
LA
I
VAL
C
V
A
AIGF
I
AV
Q
PV
F
WT
-
-M
P
TQ
L
L
SGT
A
L
A
A
G
I
GF
I
N
LFG
AV
GG
FI
A
P
I
L
R
V
K
AET
L
------
F
S
SD
A
A
G
L
LT
L
AAV
A
V
IGSL
I
I
FT
L
R
V
Consen1
Primary consensus
MLSIFKPAPnqvR
pta
ld
vrr
rw
-----
q
l
vf
gY
yL
RkNf
A
GlS
lg
gfsi
Ygf
k
d
n
r
flp
lil
a
mL
GF
a
s
s
a
m
L
-----
GfFqgmg
s
t
W
pqr
Rg
ilg
wn
hnlg
---
G
g
L
g
y
d
---
w
mf
p
Al
vg
f
f
DtPes
gl
eE
---
l
ne
see
kk
es
--
lt
qif
yvL
Nk
iW
laianiflyv
ryGi
wspty
Lk
k
a
---------
gft
e
aip
--
gtLl
gWlsd
g
rg
v
altLi
a
gvy
--
ag
--
np
--
i
cl
aiGFl
gPv
lig
a
l
pkkA
gaa
Gf
glFgylgG
aa
l
vg
d
------
f
gwaggf
l
ai
lm
v
vmEeRkirrekkiqqGG
Consen2
Secondary consensus
hka
sal
ip
ykk
mafkpfmr
p
l
l
f
s
i
f
ya
iifv
av
g
r
g
k
wi
-
---
g
t
m
a
t
f
f
lgaae
w
psti
c
-
srk
a
f
s
fy
apvaltl
l
m
h
v
al
e
aa
i
l
s
qq
rf
q
ktly
g
ddy
e
tq
t
ms
---
-
a
g
icfiy
t
ql
vi
l
fltvq
-
-
-
ayf
v
glvwvaa
f
t
mip
k
ge
c
fma
i
iig
npssllse
lav
s
vl
i
q
q
wt
-
p
f
sgt
atg
i
nt
aavi
fp
a
lk
lgtpvfgl
sddatl
m
sv
i
l
ig
k
rh
llqkrn
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character