fig|1040638.4.peg.3289
Escherichia coli O104:H4 str. LB226692
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PG
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|6666666.5357.peg.553
Escherichia coli TY-2482
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PG
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|585055.6.peg.2495
Escherichia coli 55989
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PG
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|585055.8.peg.2501
Escherichia coli 55989
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PG
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|562.375.peg.3193
Escherichia coli EC4100B
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PG
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|585034.4.peg.2258
Escherichia coli IAI1
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PG
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|585034.5.peg.2255
Escherichia coli IAI1
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PG
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|595495.4.peg.227
Escherichia coli KO11
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PG
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|566546.3.peg.1426
Escherichia coli W
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PG
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|566546.4.peg.2388
Escherichia coli W
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PG
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|216592.1.peg.3014
Escherichia coli 042
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|216592.3.peg.2559
Escherichia coli 042
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|358709.5.peg.658
Escherichia coli 101-1
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|670888.3.peg.4074
Escherichia coli 1827-70
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|344610.3.peg.1688
Escherichia coli 53638
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|344610.7.peg.4193
Escherichia coli 53638
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|525281.3.peg.4014
Escherichia coli 83972
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|655817.3.peg.2656
Escherichia coli ABU 83972
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|481805.3.peg.1547
Escherichia coli ATCC 8739
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|481805.6.peg.1539
Escherichia coli ATCC 8739
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|550672.3.peg.1927
Escherichia coli B088
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|550677.3.peg.1754
Escherichia coli B354
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|340184.3.peg.400
Escherichia coli B7A
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|340184.6.peg.417
Escherichia coli B7A
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|199310.1.peg.2674
Escherichia coli CFT073
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|199310.4.peg.2585
Escherichia coli CFT073
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|340185.3.peg.640
Escherichia coli E22
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|340185.4.peg.683
Escherichia coli E22
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|656379.3.peg.2742
Escherichia coli FVEC1302
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|656380.3.peg.2301
Escherichia coli FVEC1412
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|331112.3.peg.2200
Escherichia coli HS
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|331112.6.peg.2300
Escherichia coli HS
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|679205.4.peg.5334
Escherichia coli MS 124-1
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|679204.3.peg.243
Escherichia coli MS 145-7
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|749546.3.peg.2990
Escherichia coli MS 185-1
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|585395.4.peg.2807
Escherichia coli O103:H2 str. 12009
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|409438.11.peg.2632
Escherichia coli SE11
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|431946.3.peg.2180
Escherichia coli SE15
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|585056.7.peg.2724
Escherichia coli UMN026
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|562.376.peg.4130
Escherichia coli WV_060327
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
S
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|362663.8.peg.2267
Escherichia coli 536
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FP
L
SELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|362663.9.peg.2271
Escherichia coli 536
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FP
L
SELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|340197.3.peg.268
Escherichia coli F11
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FP
L
SELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|340197.5.peg.278
Escherichia coli F11
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FP
L
SELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|685038.3.peg.2268
Escherichia coli O83:H1 str. NRG 857C
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FP
L
SELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|439855.10.peg.2521
Escherichia coli SMS-3-5
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FP
L
SELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|656393.3.peg.3239
Escherichia coli H299
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
Y
PVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|656408.3.peg.2457
Escherichia coli H591
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
Y
PVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|679206.4.peg.2433
Escherichia coli MS 119-7
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
Y
PVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|585396.4.peg.3038
Escherichia coli O111:H- str. 11128
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
Y
PVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|573235.3.peg.3207
Escherichia coli O26:H11 str. 11368
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
Y
PVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|656443.3.peg.2917
Escherichia coli TA271
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
Y
PVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|595496.3.peg.2177
Escherichia coli BW2952
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
D
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|536056.3.peg.1525
Escherichia coli DH1
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
D
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|656414.3.peg.2581
Escherichia coli H736
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
D
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|83333.1.peg.2180
Escherichia coli K12
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
D
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|656440.3.peg.2193
Escherichia coli TA206
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLY
D
VLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|316407.3.peg.2138
Escherichia coli W3110
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
D
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|316385.5.peg.2331
Escherichia coli str. K-12 substr. DH10B
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
D
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|316385.7.peg.2385
Escherichia coli str. K-12 substr. DH10B
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
D
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|511145.12.peg.2295
Escherichia coli str. K-12 substr. MG1655
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
D
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|511145.6.peg.2279
Escherichia coli str. K-12 substr. MG1655
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
D
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|562.371.peg.5067
Escherichia coli 1044A
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|562.373.peg.3956
Escherichia coli 1125A
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|562.372.peg.5562
Escherichia coli 1212A
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|562.374.peg.3356
Escherichia coli 536A
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|550676.3.peg.2527
Escherichia coli B185
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|656419.3.peg.2966
Escherichia coli M718
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|83334.1.peg.3089
Escherichia coli O157:H7
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|444454.5.peg.2021
Escherichia coli O157:H7 str. EC4024
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|444448.5.peg.244
Escherichia coli O157:H7 str. EC4045
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|444453.5.peg.1590
Escherichia coli O157:H7 str. EC4076
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|444452.5.peg.2609
Escherichia coli O157:H7 str. EC4113
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|444450.8.peg.3334
Escherichia coli O157:H7 str. EC4115
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|444451.5.peg.792
Escherichia coli O157:H7 str. EC4196
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|444447.5.peg.378
Escherichia coli O157:H7 str. EC4206
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|478004.5.peg.1754
Escherichia coli O157:H7 str. EC4401
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|478005.5.peg.1871
Escherichia coli O157:H7 str. EC4486
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|478006.5.peg.4988
Escherichia coli O157:H7 str. EC4501
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|478007.5.peg.4994
Escherichia coli O157:H7 str. EC508
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|478008.5.peg.2367
Escherichia coli O157:H7 str. EC869
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|637388.3.peg.376
Escherichia coli O157:H7 str. FRIK2000
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|570506.3.peg.4956
Escherichia coli O157:H7 str. FRIK966
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|386585.9.peg.3229
Escherichia coli O157:H7 str. Sakai
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|544404.4.peg.3137
Escherichia coli O157:H7 str. TW14359
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|502346.5.peg.4285
Escherichia coli O157:H7 str. TW14588
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|585057.4.peg.2440
Escherichia coli IAI39
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVK
M
GEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|585057.6.peg.2443
Escherichia coli IAI39
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVK
M
GEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|656417.3.peg.2882
Escherichia coli M605
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---Y
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|753642.3.peg.2881
Escherichia coli NC101
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
S
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FP
L
SELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|405955.13.peg.2427
Escherichia coli APEC O1
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
S
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|405955.9.peg.1980
Escherichia coli APEC O1
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
S
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|714962.3.peg.2487
Escherichia coli IHE3034
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
S
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|585035.6.peg.2333
Escherichia coli S88
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
S
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|869729.3.peg.1224
Escherichia coli UM146
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
S
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|364106.7.peg.2513
Escherichia coli UTI89
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
S
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|364106.8.peg.2514
Escherichia coli UTI89
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
S
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|316401.4.peg.2678
Escherichia coli ETEC H10407
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
M
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
D
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|344601.3.peg.1443
Escherichia coli B171
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
D
K
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|344601.5.peg.1519
Escherichia coli B171
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
D
K
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|701177.3.peg.2772
Escherichia coli O55:H7 str. CB9615
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
QV
E
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|340186.3.peg.1313
Escherichia coli E110019
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
Q
YDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAE
E
QLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|340186.5.peg.1362
Escherichia coli E110019
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
Q
YDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAE
E
QLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|413997.3.peg.2229
Escherichia coli B str. REL606
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
T
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|511693.5.peg.2241
Escherichia coli BL21
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
T
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|469008.4.peg.1494
Escherichia coli BL21(DE3)
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
T
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|155864.1.peg.3094
Escherichia coli O157:H7 EDL933
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VX
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|155864.8.peg.2988
Escherichia coli O157:H7 EDL933
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VX
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
D
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|585397.7.peg.2674
Escherichia coli ED1a
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
S
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLY
D
VLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|585397.9.peg.2671
Escherichia coli ED1a
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EDKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
S
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLY
D
VLY
AT
PE
V
S
K
FPVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|331111.12.peg.2791
Escherichia coli E24377A
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
D
T
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
Y
PVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|331111.3.peg.246
Escherichia coli E24377A
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
D
T
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
Y
PVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|656437.3.peg.2479
Escherichia coli TA143
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KIS
K
PGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
D
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FP
L
SELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|670897.3.peg.3185
Escherichia coli 2362-75
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
S
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FP
L
SELAEDQLND
E
S
H
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|216593.1.peg.2536
Escherichia coli E2348/69
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
S
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FP
L
SELAEDQLND
E
S
H
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|574521.7.peg.2407
Escherichia coli O127:H6 str. E2348/69
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
WD
Q
A
F
D
V
M
EEKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
S
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
E
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
FP
L
SELAEDQLND
E
S
H
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|656444.3.peg.3201
Escherichia coli TA280
M
K
L
SRR
S
F
MK
AN
A
V
A
A
-
A
A
A
A
A
GLSV
P
-
-----G
V
AR
AV
-
VGQQ
E
A
IK
W
DK
AP
C
R
F
-
CG
TG
C
G
VL
V
GT
Q
Q
GR
V
VA
CQ
G
D
P
DA
P
V
N
R
-
G
LN
----
C
IK
G
YF
L
PKI
M
Y
G
K
DRL
T
Q
P
LL
R
M
-
K
N
G
KYDK
EG
E
F
TP
I
T
W
EQ
A
F
D
V
M
EDKF
K
TA
LKE
K
G
P
E
SI
G
M
-
F
G
SGQWTIWE
G
YA
AS
K
L
F
K
A
GFRS
N
N
-
--
----
--
--
-
I
D
P
NA
R
HC
M
A
SA
VV
G
FM
R
TFG
MDE
PMGC
YD
DIE
Q
A
DAF
V
LW
G
A
N
M
AE
MHPILWS
R
ITN
--
-
--
--
-
-
-
R
R
L
SN
Q
N
VT
V
AVLST
Y
Q
HR
S
FELA
D
NGIIFT
P
QS
D
L
VI
LNY
IA
N
Y
I
I
Q
N
N
A
IN
Q
D
F
FS
K
HVNLRKGATDI
GY
GLRP
T
H
P
LEKAAKNPGSD
AS
E
P
M
SF
E
D
YKA
FV
----
-
-
-A
EY
T
L
E
KT
A
E
M
TG
V
P
K
D
Q
LE
QLA
QLYA
DP
NKK
V
I
SY
-
W
TM
G
FNQ
H
T
R
G
V
W
A
N
NLV
Y
N
L
H
L
LTG
KISQPGCGPFSL
T
G
QP
S
ACGT
ARE
V
G
T
F
A---H
R
L
P
ADM
V
V
T
N
E
KH
R
D
I
C
E
K
K
W
N
--
I
PS
GT
IPAKIGLHAVAQDR
A
L
K
DG
----
-
KL
N
V
---
-Y
W
T
MC
T
N
-
-
-
N
MQ
AG
P
N
I
NE
E
R
MPGWR
D
PR
--
N
F
I
I
V
S
D
P
Y
P
T
V
SA
LA
AD
LI
LP
T
A
M
WV
E
K
E
G
AYG
N
AER
RTQ
-
-
-
-
F
WR
Q
QVQAP
G
E
A
K
S
DL
W
Q
L
VQ
F
SR
R
F
----
-
-
-
----
K
T
E
E
V
W
P
E
D
L
L
AK
KP
E
LRGKTLYEVLY
AT
PE
V
S
K
Y
PVSELAEDQLND
E
S
R
EL
G
FYL
Q
K
G
LFEEYAWFGRG
H
GH
D
L
A
--
P
F
D
D
YH
K
A
RG
L
R
W
P
VVN
GK
-----
--
--
-
-
E
T
Q
W
RY
S
EG
N
DPYVKAGEGYKFYGKPDGKA
VI
F
A
LP
-
-
---
FE
PAAE
A
PDEE
Y
D
L
W
L
S
TGRVL
E
H
W
H
TG
S
M
TRRVPE
L
HR
A
F
P
EA
V
LF
I
H
P
L
DA
K
AR
DL
RR
GD
K
V
K
V
VS
R
RGEV
ISI
VETRG
R
NR
P
--
-
-
-
P
QG
LV
YM
P
F
-
----F
D
A
AQ
L
V
N
K
LT
LD
ATD
PL
S
K
ETD
F
K
K
CA
V
KL
EKV
fig|749546.3.peg.1788
Escherichia coli MS 185-1 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
H
I
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATKM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
X
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
E
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
SN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|562.376.peg.4705
Escherichia coli WV_060327 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATKM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
K
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
E
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
SN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|869729.3.peg.2789
Escherichia coli UM146 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATKM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
E
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|362663.8.peg.918
Escherichia coli 536 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATKM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
E
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QE
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
SN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|362663.9.peg.918
Escherichia coli 536 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATKM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
E
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QE
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
SN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|655817.3.peg.985
Escherichia coli ABU 83972 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATKM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
E
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
SN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|199310.1.peg.1003
Escherichia coli CFT073 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATKM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
E
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
SN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|340197.3.peg.2200
Escherichia coli F11 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATKM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
E
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QE
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
SN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|340197.5.peg.2314
Escherichia coli F11 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATKM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
E
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QE
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
SN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|749550.3.peg.2131
Escherichia coli MS 200-1 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATKM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
E
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QE
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
SN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|749528.3.peg.1712
Escherichia coli MS 45-1 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATKM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
E
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
SN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|753642.3.peg.709
Escherichia coli NC101 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATKM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
E
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
SN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|685038.3.peg.828
Escherichia coli O83:H1 str. NRG 857C (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATKM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
E
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
SN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|656440.3.peg.808
Escherichia coli TA206 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATKM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
E
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
SN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|656379.3.peg.1743
Escherichia coli FVEC1302 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
Q
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|656380.3.peg.1571
Escherichia coli FVEC1412 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
Q
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|749549.3.peg.5326
Escherichia coli MS 198-1 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
Q
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|585056.7.peg.1282
Escherichia coli UMN026 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
Q
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|656417.3.peg.1134
Escherichia coli M605 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
II
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|1040638.4.peg.4742
Escherichia coli O104:H4 str. LB226692 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGN
T
G
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|6666666.5357.peg.773
Escherichia coli TY-2482 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGN
T
G
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|585055.8.peg.956
Escherichia coli 55989 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGN
T
G
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|358709.5.peg.3408
Escherichia coli 101-1 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|670888.3.peg.1509
Escherichia coli 1827-70 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|344610.3.peg.3941
Escherichia coli 53638 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|344610.7.peg.770
Escherichia coli 53638 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|481805.3.peg.2902
Escherichia coli ATCC 8739 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|550676.3.peg.362
Escherichia coli B185 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|536056.3.peg.2902
Escherichia coli DH1 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|316401.4.peg.1107
Escherichia coli ETEC H10407 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|656414.3.peg.1101
Escherichia coli H736 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|331112.3.peg.927
Escherichia coli HS (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|331112.6.peg.966
Escherichia coli HS (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|83333.1.peg.879
Escherichia coli K12 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|749538.3.peg.2886
Escherichia coli MS 116-1 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|749540.3.peg.2700
Escherichia coli MS 146-1 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|749544.3.peg.632
Escherichia coli MS 175-1 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|749547.3.peg.1841
Escherichia coli MS 187-1 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|749548.3.peg.2260
Escherichia coli MS 196-1 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|316407.3.peg.860
Escherichia coli W3110 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|511145.12.peg.924
Escherichia coli str. K-12 substr. MG1655 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|344601.3.peg.2709
Escherichia coli B171 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|340184.3.peg.2686
Escherichia coli B7A (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|340184.6.peg.2809
Escherichia coli B7A (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|340185.3.peg.3053
Escherichia coli E22 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|340185.4.peg.3218
Escherichia coli E22 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|562.375.peg.4543
Escherichia coli EC4100B (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|595495.4.peg.3357
Escherichia coli KO11 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|679204.3.peg.2432
Escherichia coli MS 145-7 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|749545.3.peg.4319
Escherichia coli MS 182-1 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|749531.3.peg.2922
Escherichia coli MS 69-1 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|749532.3.peg.782
Escherichia coli MS 78-1 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|585395.4.peg.987
Escherichia coli O103:H2 str. 12009 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|585396.4.peg.1002
Escherichia coli O111:H- str. 11128 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|656437.3.peg.1030
Escherichia coli TA143 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
DV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|656444.3.peg.1511
Escherichia coli TA280 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|566546.3.peg.1883
Escherichia coli W (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|566546.4.peg.992
Escherichia coli W (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|656393.3.peg.1656
Escherichia coli H299 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
L
P
AKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|749527.3.peg.2432
Escherichia coli MS 21-1 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
L
P
AKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|439855.10.peg.2382
Escherichia coli SMS-3-5 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
L
P
AKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|216592.1.peg.227
Escherichia coli 042 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
V
LTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|562.371.peg.2141
Escherichia coli 1044A (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSG
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|562.373.peg.1124
Escherichia coli 1125A (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSG
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|562.372.peg.990
Escherichia coli 1212A (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSG
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|562.374.peg.2523
Escherichia coli 536A (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSG
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|83334.1.peg.1047
Escherichia coli O157:H7 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSG
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|444454.5.peg.5475
Escherichia coli O157:H7 str. EC4024 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSG
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|444449.5.peg.4408
Escherichia coli O157:H7 str. EC4042 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSG
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|444448.5.peg.3684
Escherichia coli O157:H7 str. EC4045 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSG
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|444453.5.peg.5057
Escherichia coli O157:H7 str. EC4076 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSG
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|444452.5.peg.4998
Escherichia coli O157:H7 str. EC4113 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSG
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|444450.8.peg.1141
Escherichia coli O157:H7 str. EC4115 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSG
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|444451.5.peg.3774
Escherichia coli O157:H7 str. EC4196 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSG
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|444447.5.peg.3891
Escherichia coli O157:H7 str. EC4206 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSG
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|478004.5.peg.3678
Escherichia coli O157:H7 str. EC4401 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSG
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|478006.5.peg.3407
Escherichia coli O157:H7 str. EC4501 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSG
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|478007.5.peg.4035
Escherichia coli O157:H7 str. EC508 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSG
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|478008.5.peg.2563
Escherichia coli O157:H7 str. EC869 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSG
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|637388.3.peg.4472
Escherichia coli O157:H7 str. FRIK2000 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSG
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|570506.3.peg.2034
Escherichia coli O157:H7 str. FRIK966 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSG
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|386585.9.peg.1096
Escherichia coli O157:H7 str. Sakai (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSG
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|544404.4.peg.1007
Escherichia coli O157:H7 str. TW14359 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSG
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|502346.5.peg.193
Escherichia coli O157:H7 str. TW14588 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSG
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|701177.3.peg.1112
Escherichia coli O55:H7 str. CB9615 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSG
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|656408.3.peg.952
Escherichia coli H591 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTP
Q
WA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
K
P
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|331111.3.peg.3466
Escherichia coli E24377A (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMT
E
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|656419.3.peg.1188
Escherichia coli M718 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AK
S
PEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|679206.4.peg.3406
Escherichia coli MS 119-7 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTP
Q
WA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|656443.3.peg.1179
Escherichia coli TA271 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTP
Q
WA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|340186.3.peg.3976
Escherichia coli E110019 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
L
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-TKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|679205.4.peg.1027
Escherichia coli MS 124-1 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTP
Q
WA
S
QITGIP
A
E
KIIQLAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGN
T
G
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|749533.3.peg.1023
Escherichia coli MS 84-1 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTP
Q
WA
S
QITGIP
A
E
KIIQLAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGN
T
G
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|679207.4.peg.2010
Escherichia coli MS 107-1 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTP
Q
WA
S
QITGIP
A
E
KIIQLAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|409438.11.peg.1082
Escherichia coli SE11 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTP
Q
WA
S
QITGIP
A
E
KIIQLAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|670897.3.peg.4690
Escherichia coli 2362-75 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DR
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
G
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
E
FLDKYC
--------
VGYDEK
-
TL
S
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IV
A
ID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
NN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|749537.3.peg.4337
Escherichia coli MS 115-1 (13-814/814)
E
V
SRR
G
L
V
KTTAIG
G
LA
M
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSD
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
G
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
S
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|316401.4.peg.1867
Escherichia coli ETEC H10407 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRN
A
AA
AV
-
QQAR
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
Q
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
E
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
L
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|595496.3.peg.1547
Escherichia coli BW2952 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRN
A
AA
AV
-
QQAR
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
E
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|536056.3.peg.2167
Escherichia coli DH1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRN
A
AA
AV
-
QQAR
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
E
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|656414.3.peg.1889
Escherichia coli H736 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRN
A
AA
AV
-
QQAR
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
E
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|83333.1.peg.1573
Escherichia coli K12 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRN
A
AA
AV
-
QQAR
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
E
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|749538.3.peg.4136
Escherichia coli MS 116-1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRN
A
AA
AV
-
QQAR
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
E
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|749540.3.peg.4220
Escherichia coli MS 146-1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRN
A
AA
AV
-
QQAR
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
E
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|749548.3.peg.4734
Escherichia coli MS 196-1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRN
A
AA
AV
-
QQAR
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
E
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|316407.3.peg.1544
Escherichia coli W3110 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRN
A
AA
AV
-
QQAR
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
E
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|316385.5.peg.1699
Escherichia coli str. K-12 substr. DH10B (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRN
A
AA
AV
-
QQAR
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
E
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|316385.7.peg.1744
Escherichia coli str. K-12 substr. DH10B (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRN
A
AA
AV
-
QQAR
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
E
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|511145.12.peg.1658
Escherichia coli str. K-12 substr. MG1655 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRN
A
AA
AV
-
QQAR
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
E
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|511145.6.peg.1642
Escherichia coli str. K-12 substr. MG1655 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRN
A
AA
AV
-
QQAR
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
E
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|685038.3.peg.1602
Escherichia coli O83:H1 str. NRG 857C (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
EA
AV
-
QQAN
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
K
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
N
LP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERSA
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGN
V
DVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|481805.3.peg.2201
Escherichia coli ATCC 8739 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRN
A
AA
S
V
-
QQAR
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
E
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|481805.6.peg.2194
Escherichia coli ATCC 8739 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRN
A
AA
S
V
-
QQAR
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
E
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|525281.3.peg.976
Escherichia coli 83972 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
EA
AV
-
QQAN
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
K
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERSA
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|655817.3.peg.1868
Escherichia coli ABU 83972 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
EA
AV
-
QQAN
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
K
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERSA
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|405955.13.peg.1670
Escherichia coli APEC O1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
EA
AV
-
QQAN
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
K
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERSA
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|405955.9.peg.1355
Escherichia coli APEC O1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
EA
AV
-
QQAN
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
K
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERSA
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|199310.1.peg.1915
Escherichia coli CFT073 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
EA
AV
-
QQAN
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
K
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERSA
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|199310.4.peg.1846
Escherichia coli CFT073 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
EA
AV
-
QQAN
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
K
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERSA
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|749546.3.peg.3879
Escherichia coli MS 185-1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
EA
AV
-
QQAN
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
K
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERSA
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|749528.3.peg.3857
Escherichia coli MS 45-1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
EA
AV
-
QQAN
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
K
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERSA
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|585035.6.peg.1625
Escherichia coli S88 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
EA
AV
-
QQAN
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
K
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERSA
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|364106.7.peg.1817
Escherichia coli UTI89 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
EA
AV
-
QQAN
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
K
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERSA
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|364106.8.peg.1820
Escherichia coli UTI89 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
EA
AV
-
QQAN
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
K
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERSA
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|155864.1.peg.1079
Escherichia coli O157:H7 EDL933 (2-785/785)
AS
S
A
L
TLPF
SRIAHA
V
DS
A
IP
TKSG
EK
VI
W
--
SA
C
T
VNCGSRC
P
LR
M
HV
V
D
GE
I
KY
VE
T
D
N
TG
D
D
N
Y
D
G
L
HQVRACLRGRS
M
RRR
V
Y
N
PDRL
K
YPMKRVG
A
RG
----
EGKFERISW
E
EA
Y
D
I
I
ATNM
Q
RL
I
KEYGNE
SI
Y
L
N
YGT
-------
G
TL
GG
T
MT
R
S
WPPG
N
T
L
VA
RLMN
CC
GG
Y
LN
H
YG
D
YS
S
AQI
AE
G
LN
YT
Y
G
GWA
DGNS
PS
DIENSKLVV
L
FGNNP
G
E
------
TRMSGGG
V
TY
YL
E
Q
AR
Q
K
SNA
R
MI
I
-
IDPRY
T
DT
G
AGREDEW
I
PIRPGTD
A
AL
VNG
L
A
Y
V
M
I
T
EN
L
VDQ
A
FLDKYC
--------
VGYDEK
-
TLP
-----------
ASAP
K
N
-
G
HYKAYILGEG
P
D
GV
AKTPEWA
X
QITG
V
P
A
DKII
K
LAREIG
ST
KPA
F
I
S
QGW
--
GPQRHANGE
I
A
T
RAI
S
ML
A
ILTGNV
--------
GINGGNSG
---
ARE
-
GSY
SLPFV
R
M
P
---
T
L
E
NP
IQ
T
S
IS
M
F
M
WTDAI
ER
G
P
-----------
EMTA
L
RDGVRGK
D
KLDVPIK
MI
W
N
YA
G
N
C
L
I
NQH
SE
IN
R
THE
I
L
---
QD
DK
KCE
L
IVVID
C
H
MT
S
SAKYADILLPD
C
T
AS
EQ
M
D
FAL
D
ASC
GNM
S
Y
V
IF
ND
Q
VIKPR
FE
C
K
T
IY
E
M
T
SE
L
AKRLG
--
V
E
Q
Q
FTEGRTQE
E
W
M
R
H
L
Y
A
Q
SR
E
-----------
AI
PELP
T
F
-----------
EE
F
R
KQ
GIFKK
R
D
----------
P
Q
GH
H
VA
YK
AFR
E
DPQANPL
T
TP
--
SGKIEIYS
QA
LA
D
IA
A
TWEL
P
EG
D
--------------------
VI
D
PLP
I
Y
TPG
FE
SYQD
P
LNKQ
YPLQL
T
GFHYK
S
R
V
H
--
S
T
YGN
V
DVL
KA
AC
R
QE
M
-
WINP
L
DAQ
K
RGI
HN
GD
K
VR
I
FN
D
RGEV
HIE
AKVTPR
MM
PGV
V
A
L
G
E
GAW
YD
P
D
-
-AKRV
D
K
GG
C
IN
V
LT
TQ
RPSPLAKGNP
S
H
T
NLVQ
V
EKV
fig|753642.3.peg.1576
Escherichia coli NC101 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
D
G
F
S
LPF
T--LRS
A
EA
AV
-
QQAN
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
K
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERSA
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|656440.3.peg.4366
Escherichia coli TA206 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAN
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
N
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
E
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
V
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERSI
F
PLQL
F
GFHYK
S
R
A
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEKV
fig|670897.3.peg.2337
Escherichia coli 2362-75 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
EA
AV
-
QQAN
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
K
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
EHSA
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|216593.1.peg.355
Escherichia coli E2348/69 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
EA
AV
-
QQAN
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
K
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
EHSA
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|574521.7.peg.1708
Escherichia coli O127:H6 str. E2348/69 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
EA
AV
-
QQAN
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
K
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
EHSA
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|595495.4.peg.2853
Escherichia coli KO11 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAR
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IV
I
I
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|566546.3.peg.1066
Escherichia coli W (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAR
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IV
I
I
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|566546.4.peg.1739
Escherichia coli W (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAR
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IV
I
I
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|550676.3.peg.1891
Escherichia coli B185 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LHS
A
AA
AV
-
QQAR
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
AW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KL
E
VPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|340184.3.peg.1015
Escherichia coli B7A (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAR
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|340184.6.peg.1050
Escherichia coli B7A (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAR
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|679204.3.peg.504
Escherichia coli MS 145-7 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAR
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|585395.4.peg.1810
Escherichia coli O103:H2 str. 12009 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAR
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|344601.3.peg.331
Escherichia coli B171 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAR
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|344601.5.peg.329
Escherichia coli B171 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAR
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|331112.3.peg.1563
Escherichia coli HS (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
IW
VE
T
D
N
TG
N
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
T
CQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
K
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
F
A
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
I
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|331112.6.peg.1630
Escherichia coli HS (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
IW
VE
T
D
N
TG
N
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
T
CQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
K
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
F
A
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
I
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|562.375.peg.1686
Escherichia coli EC4100B (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
T
V
-
QQAS
EK
VI
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVG
T
RG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|749532.3.peg.1355
Escherichia coli MS 78-1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
T
V
-
QQAS
EK
VI
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVG
T
RG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|409438.11.peg.1855
Escherichia coli SE11 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
T
V
-
QQAS
EK
VI
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVG
T
RG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|679205.4.peg.1617
Escherichia coli MS 124-1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
T
V
-
QQAS
EK
VI
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVG
T
RG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
I
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|749533.3.peg.4939
Escherichia coli MS 84-1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
T
V
-
QQAS
EK
VI
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVG
T
RG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
I
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|585034.4.peg.1621
Escherichia coli IAI1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
T
V
-
QQAS
EK
VI
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVG
T
RG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IV
I
I
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|585034.5.peg.1616
Escherichia coli IAI1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
T
V
-
QQAS
EK
VI
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVG
T
RG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IV
I
I
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|439855.10.peg.1773
Escherichia coli SMS-3-5 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
S
AA
AV
-
QQAS
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
N
D
E
Y
-
GN
Q
QVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFR
E
DP
E
ANPL
K
TP
--
SGKIEIYS
NR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|656417.3.peg.2077
Escherichia coli M605 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
K
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGP
H
V
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|431946.3.peg.1505
Escherichia coli SE15 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
K
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|656393.3.peg.2375
Escherichia coli H299 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|340186.3.peg.17
Escherichia coli E110019 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
T
V
-
QQAS
EK
VI
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVG
T
RG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IV
I
I
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
L
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|340186.5.peg.18
Escherichia coli E110019 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
T
V
-
QQAS
EK
VI
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVG
T
RG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IV
I
I
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
L
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|562.371.peg.4430
Escherichia coli 1044A (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
E
Q
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
AW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
I
T
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
S
RE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|562.372.peg.4662
Escherichia coli 1212A (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
E
Q
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
AW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
I
T
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
S
RE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|562.374.peg.4447
Escherichia coli 536A (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
E
Q
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
AW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
I
T
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
S
RE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|83334.1.peg.2322
Escherichia coli O157:H7 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
E
Q
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
AW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
I
T
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
S
RE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|155864.1.peg.2330
Escherichia coli O157:H7 EDL933 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
E
Q
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
AW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
I
T
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
S
RE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|155864.8.peg.2169
Escherichia coli O157:H7 EDL933 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
E
Q
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
AW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
I
T
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
S
RE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|444454.5.peg.5571
Escherichia coli O157:H7 str. EC4024 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
E
Q
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
AW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
I
T
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
S
RE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|444449.5.peg.517
Escherichia coli O157:H7 str. EC4042 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
E
Q
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
AW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
I
T
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
S
RE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|444448.5.peg.4825
Escherichia coli O157:H7 str. EC4045 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
E
Q
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
AW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
I
T
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
S
RE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|444453.5.peg.4690
Escherichia coli O157:H7 str. EC4076 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
E
Q
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
AW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
I
T
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
S
RE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|444452.5.peg.3536
Escherichia coli O157:H7 str. EC4113 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
E
Q
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
AW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
I
T
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
S
RE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|444450.8.peg.2337
Escherichia coli O157:H7 str. EC4115 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
E
Q
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
AW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
I
T
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
S
RE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|444451.5.peg.3357
Escherichia coli O157:H7 str. EC4196 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
E
Q
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
AW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
I
T
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
S
RE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|444447.5.peg.5164
Escherichia coli O157:H7 str. EC4206 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
E
Q
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
AW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
I
T
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
S
RE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|478004.5.peg.4148
Escherichia coli O157:H7 str. EC4401 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
E
Q
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
AW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
I
T
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
S
RE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|478006.5.peg.4087
Escherichia coli O157:H7 str. EC4501 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
E
Q
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
AW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
I
T
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
S
RE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|478007.5.peg.3501
Escherichia coli O157:H7 str. EC508 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
E
Q
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
AW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
I
T
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
S
RE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|478008.5.peg.4497
Escherichia coli O157:H7 str. EC869 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
E
Q
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
AW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
I
T
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
S
RE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|637388.3.peg.5057
Escherichia coli O157:H7 str. FRIK2000 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
E
Q
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
AW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
I
T
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
S
RE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|570506.3.peg.4176
Escherichia coli O157:H7 str. FRIK966 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
E
Q
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
AW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
I
T
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
S
RE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|386585.9.peg.2401
Escherichia coli O157:H7 str. Sakai (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
E
Q
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
AW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
I
T
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
S
RE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|544404.4.peg.2200
Escherichia coli O157:H7 str. TW14359 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
E
Q
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
AW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
I
T
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
S
RE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|502346.5.peg.5112
Escherichia coli O157:H7 str. TW14588 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
E
Q
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
AW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
I
T
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
S
RE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|562.373.peg.5332
Escherichia coli 1125A (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
E
Q
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
AW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
I
T
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
S
RE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
L
D
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|670888.3.peg.74
Escherichia coli 1827-70 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
IW
VE
T
D
N
TG
N
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKF
K
RISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
T
CQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
K
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|550672.3.peg.2427
Escherichia coli B088 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
T
V
-
QQAS
EK
VI
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVG
T
RG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|656379.3.peg.2055
Escherichia coli FVEC1302 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
N
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGP
E
V
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|656380.3.peg.3018
Escherichia coli FVEC1412 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
N
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGP
E
V
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|749549.3.peg.5227
Escherichia coli MS 198-1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
N
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGP
E
V
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|656437.3.peg.1798
Escherichia coli TA143 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
N
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|585056.7.peg.2059
Escherichia coli UMN026 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
N
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGP
E
V
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|358709.5.peg.1102
Escherichia coli 101-1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VV
W
--
GA
C
S
VNCGSRC
A
L
C
LHV
K
D
NE
V
IW
VE
T
D
N
TG
N
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
E
D
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
T
CQGW
--
GP
K
R
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|550677.3.peg.2969
Escherichia coli B354 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
D
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|413997.3.peg.1631
Escherichia coli B str. REL606 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
IW
VE
T
D
N
TG
N
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
E
D
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
T
CQGW
--
GP
K
R
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|511693.5.peg.1656
Escherichia coli BL21 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
IW
VE
T
D
N
TG
N
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
E
D
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
T
CQGW
--
GP
K
R
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|469008.4.peg.2118
Escherichia coli BL21(DE3) (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
IW
VE
T
D
N
TG
N
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
E
D
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
T
CQGW
--
GP
K
R
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|656444.3.peg.2478
Escherichia coli TA280 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
I
I
SDNL
R
RI
LKEYGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KI
S
QLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
T
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|585057.4.peg.1537
Escherichia coli IAI39 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
N
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
I
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
L
T
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
R
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|585057.6.peg.1537
Escherichia coli IAI39 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
N
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
I
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
L
T
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
R
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|1040638.4.peg.3633
Escherichia coli O104:H4 str. LB226692 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VI
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVG
T
RG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDV
S
IK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|585055.6.peg.1782
Escherichia coli 55989 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VI
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVG
T
RG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDV
S
IK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|585055.8.peg.1786
Escherichia coli 55989 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VI
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVG
T
RG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDV
S
IK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|656408.3.peg.1726
Escherichia coli H591 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VI
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVG
T
RG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|679206.4.peg.1318
Escherichia coli MS 119-7 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VI
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVG
T
RG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|670888.3.peg.75
Escherichia coli 1827-70 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EV
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|562.375.peg.1687
Escherichia coli EC4100B (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EV
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|562.375.peg.1688
Escherichia coli EC4100B (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EV
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|331112.3.peg.1564
Escherichia coli HS (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EV
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|331112.6.peg.1631
Escherichia coli HS (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EV
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|409438.11.peg.1856
Escherichia coli SE11 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EV
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|656393.3.peg.2376
Escherichia coli H299 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
I
I
SDNL
R
RI
LKEYGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
T
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|216592.1.peg.2169
Escherichia coli 042 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HY
E
AYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
E
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GG
S
SG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|216592.3.peg.1805
Escherichia coli 042 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HY
E
AYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
E
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GG
S
SG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|749527.3.peg.4301
Escherichia coli MS 21-1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
N
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
G
N
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|585395.4.peg.1811
Escherichia coli O103:H2 str. 12009 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWL
L
IRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
G
K
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|749545.3.peg.5107
Escherichia coli MS 182-1 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EV
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
G
K
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|749532.3.peg.1356
Escherichia coli MS 78-1 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EV
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
G
K
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|749532.3.peg.1357
Escherichia coli MS 78-1 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EV
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
G
K
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|749531.3.peg.4805
Escherichia coli MS 69-1 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
N
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
E
NPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|331111.12.peg.2081
Escherichia coli E24377A (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VI
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVG
T
RG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IV
I
I
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|331111.3.peg.4224
Escherichia coli E24377A (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VI
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVG
T
RG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IV
I
I
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SR
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWNS
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|6666666.5357.peg.2358
Escherichia coli TY-2482 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
EK
VI
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
TW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVG
T
RG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
ARE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
NT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDV
S
IK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDP
P
ERRT
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNID
L
L
KA
AC
R
QEV
-
WINPIDAQ
K
RGI
AN
GD
M
VRVFN
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|701177.3.peg.1978
Escherichia coli O55:H7 str. CB9615 (10-808/808)
ISRR
T
L
V
K
S
TAIG
S
LA
L
A
A
G
G
F
S
LPF
T--LRS
A
AA
AV
-
QQAS
E
Q
VV
W
--
GA
C
S
VNCGSRC
A
LRLHV
K
D
NE
V
AW
VE
T
D
N
TG
S
D
E
Y
-
GNHQVRACLRGRSIRRR
I
N
H
PDRL
N
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
ASSL
K
KT
V
E
Q
YGNEAV
Y
I
Q
Y
SS
-------
G
IV
GG
N
MT
R
S
SPSA
S
A
-
VK
RLMN
CY
GG
S
LN
Q
YG
S
YS
T
AQI
SC
A
MP
YT
Y
G
S-N
DGNS
TT
DIENSKLVVMFGNNPAE
------
TRMSGGG
I
TY
LL
E
K
S
RE
K
SNA
K
MIV
-
IDPRY
T
DT
A
AGREDEWLPIRPGTD
A
AL
VAG
IA
W
VLI
N
EN
L
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
D
AP
K
N
-
G
HYKAYILGEG
D
D
KT
AKTP
Q
WA
S
QITGIP
V
D
R
II
K
LAREIG
TA
KPA
Y
ICQGW
--
GPQR
Q
ANGE
L
T
A
RAI
A
ML
P
ILTGNV
--------
GI
S
GGNSG
---
ARE
-
ST
Y
TITIE
R
L
P
---
V
L
D
NP
VK
T
S
IS
C
F
S
WTDAI
DH
G
P
-----------
Q
MTA
I
RDGVRGK
D
KLDVPIK
FI
W
N
YA
G
N
T
L
V
NQH
SD
IN
K
THE
I
L
---
QD
ES
KCE
M
IVVI
E
N
FMT
S
SAKYADILLPD
L
M
TV
EQED
IIP
N
DYA
GNM
G
Y
L
IF
LQ
P
VTSEK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
K
FTEGRTQE
Q
W
L
Q
H
L
Y
AK
ML
A
-----------
KD
P
A
LP
S
Y
-----------
D
E
L
K
KM
GI
Y
K
R
K
D
----------
P
N
GH
F
VA
YK
AFRDDP
E
ANPL
K
TP
--
SGKIEIYS
SK
LA
E
IA
R
TWEL
E
KDE
--------------------
VI
S
PLP
V
Y
AST
FE
GWDS
P
ERST
F
PLQL
F
GFHYK
S
R
T
H
--
S
T
YGNIDVL
KA
AC
R
QEV
-
WINPIDAQ
K
C
GI
AN
GD
M
VRV
Y
N
H
RGEV
RLP
AKVTPR
IL
PGV
S
A
M
GQGAW
HE
A
N
M
SGDKI
D
H
GG
C
V
N
T
LT
TL
RPSPLAKGNP
Q
H
T
NLV
E
IEK
I
fig|340184.3.peg.1014
Escherichia coli B7A (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YR
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
V
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|585034.4.peg.1622
Escherichia coli IAI1 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
Q
N
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|585034.5.peg.1617
Escherichia coli IAI1 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
Q
N
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|749531.3.peg.4806
Escherichia coli MS 69-1 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LKEYGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
T
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|562.371.peg.4431
Escherichia coli 1044A (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
S
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|562.373.peg.5333
Escherichia coli 1125A (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
S
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|562.372.peg.4663
Escherichia coli 1212A (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
S
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|562.372.peg.4664
Escherichia coli 1212A (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
S
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|562.374.peg.4446
Escherichia coli 536A (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
S
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|83334.1.peg.2323
Escherichia coli O157:H7 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
S
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|444454.5.peg.5572
Escherichia coli O157:H7 str. EC4024 (13-807/807)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
S
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|444449.5.peg.518
Escherichia coli O157:H7 str. EC4042 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
S
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|444448.5.peg.4826
Escherichia coli O157:H7 str. EC4045 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
S
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|444453.5.peg.4691
Escherichia coli O157:H7 str. EC4076 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
S
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|444452.5.peg.3535
Escherichia coli O157:H7 str. EC4113 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
S
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|444450.8.peg.2338
Escherichia coli O157:H7 str. EC4115 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
S
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|444451.5.peg.3358
Escherichia coli O157:H7 str. EC4196 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
S
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|444447.5.peg.5163
Escherichia coli O157:H7 str. EC4206 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
S
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|478004.5.peg.4147
Escherichia coli O157:H7 str. EC4401 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
S
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|478005.5.peg.5248
Escherichia coli O157:H7 str. EC4486 (13-807/807)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
S
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|478006.5.peg.4086
Escherichia coli O157:H7 str. EC4501 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
S
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|478007.5.peg.3502
Escherichia coli O157:H7 str. EC508 (13-807/807)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
S
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|478008.5.peg.4498
Escherichia coli O157:H7 str. EC869 (13-807/807)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
S
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|637388.3.peg.5056
Escherichia coli O157:H7 str. FRIK2000 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
S
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|570506.3.peg.4177
Escherichia coli O157:H7 str. FRIK966 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
S
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|386585.9.peg.2402
Escherichia coli O157:H7 str. Sakai (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
S
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|544404.4.peg.2201
Escherichia coli O157:H7 str. TW14359 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
S
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|502346.5.peg.5111
Escherichia coli O157:H7 str. TW14588 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
S
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|679204.3.peg.505
Escherichia coli MS 145-7 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
V
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|585396.4.peg.2137
Escherichia coli O111:H- str. 11128 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
V
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|573235.3.peg.2330
Escherichia coli O26:H11 str. 11368 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
V
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|670897.3.peg.2336
Escherichia coli 2362-75 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
QA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
T
D
SI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|216593.1.peg.356
Escherichia coli E2348/69 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
QA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
T
D
SI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|585397.7.peg.1776
Escherichia coli ED1a (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
QA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
T
D
SI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|585397.9.peg.1771
Escherichia coli ED1a (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
QA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
T
D
SI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|574521.7.peg.1709
Escherichia coli O127:H6 str. E2348/69 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
QA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
T
D
SI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|656417.3.peg.2078
Escherichia coli M605 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
QA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
S
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
T
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRGT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|656417.3.peg.2079
Escherichia coli M605 (13-807/807)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
QA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
S
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
T
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRGT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|358709.5.peg.1103
Escherichia coli 101-1 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|481805.3.peg.2200
Escherichia coli ATCC 8739 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|481805.6.peg.2193
Escherichia coli ATCC 8739 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|413997.3.peg.1632
Escherichia coli B str. REL606 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|550672.3.peg.2428
Escherichia coli B088 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|550676.3.peg.1892
Escherichia coli B185 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|511693.5.peg.1657
Escherichia coli BL21 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|469008.4.peg.2117
Escherichia coli BL21(DE3) (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|595496.3.peg.1548
Escherichia coli BW2952 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|536056.3.peg.2166
Escherichia coli DH1 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|340186.3.peg.16
Escherichia coli E110019 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|340186.5.peg.17
Escherichia coli E110019 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|331111.12.peg.2082
Escherichia coli E24377A (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|331111.3.peg.4225
Escherichia coli E24377A (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|316401.4.peg.1868
Escherichia coli ETEC H10407 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|316401.4.peg.1869
Escherichia coli ETEC H10407 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|656408.3.peg.1727
Escherichia coli H591 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|656408.3.peg.1728
Escherichia coli H591 (13-807/807)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|83333.1.peg.1574
Escherichia coli K12 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|595495.4.peg.2852
Escherichia coli KO11 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|679207.4.peg.4677
Escherichia coli MS 107-1 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|679207.4.peg.4678
Escherichia coli MS 107-1 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|749538.3.peg.4137
Escherichia coli MS 116-1 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|679206.4.peg.1317
Escherichia coli MS 119-7 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|749540.3.peg.4221
Escherichia coli MS 146-1 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|656443.3.peg.2236
Escherichia coli TA271 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|566546.3.peg.1065
Escherichia coli W (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|566546.4.peg.1740
Escherichia coli W (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|316407.3.peg.1545
Escherichia coli W3110 (13-807/807)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|316385.5.peg.1700
Escherichia coli str. K-12 substr. DH10B (13-807/807)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|316385.7.peg.1745
Escherichia coli str. K-12 substr. DH10B (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|511145.12.peg.1659
Escherichia coli str. K-12 substr. MG1655 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|511145.6.peg.1643
Escherichia coli str. K-12 substr. MG1655 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|701177.3.peg.1979
Escherichia coli O55:H7 str. CB9615 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
ET
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|525281.3.peg.975
Escherichia coli 83972 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
QA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
L
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
P
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TI
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
V
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|655817.3.peg.1869
Escherichia coli ABU 83972 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
QA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
L
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
P
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TI
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
V
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|655817.3.peg.1870
Escherichia coli ABU 83972 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
QA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
L
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
P
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TI
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
V
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|656414.3.peg.1890
Escherichia coli H736 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
K
MTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|656414.3.peg.1891
Escherichia coli H736 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
K
MTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|1040638.4.peg.3634
Escherichia coli O104:H4 str. LB226692 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
G
K
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|6666666.5357.peg.2359
Escherichia coli TY-2482 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
G
K
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|585055.6.peg.1783
Escherichia coli 55989 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
G
K
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|585055.8.peg.1787
Escherichia coli 55989 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
G
K
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|344601.3.peg.332
Escherichia coli B171 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
G
K
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|344601.5.peg.330
Escherichia coli B171 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
G
K
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|679205.4.peg.1618
Escherichia coli MS 124-1 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
G
K
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|679205.4.peg.1619
Escherichia coli MS 124-1 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
G
K
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|749533.3.peg.4938
Escherichia coli MS 84-1 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
G
K
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|216592.1.peg.2170
Escherichia coli 042 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
ET
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
T
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|216592.3.peg.1806
Escherichia coli 042 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
ET
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
T
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|550677.3.peg.2970
Escherichia coli B354 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
ET
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
T
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|155864.1.peg.2331
Escherichia coli O157:H7 EDL933 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
S
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
T
X
RAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
X
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
X
PSPL
X
KGNP
S
H
S
NLVQIEKV
fig|155864.8.peg.2170
Escherichia coli O157:H7 EDL933 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
S
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
T
X
RAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
T
N
E
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
X
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
X
PSPL
X
KGNP
S
H
S
NLVQIEKV
fig|749548.3.peg.4735
Escherichia coli MS 196-1 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
V
KRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|199310.1.peg.1916
Escherichia coli CFT073 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
QA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
L
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
P
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
V
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|199310.4.peg.1847
Escherichia coli CFT073 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
QA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
L
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
P
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
V
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|749546.3.peg.3878
Escherichia coli MS 185-1 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
QA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
L
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
P
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
V
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|749528.3.peg.3856
Escherichia coli MS 45-1 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
QA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
L
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
P
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
V
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|656379.3.peg.2056
Escherichia coli FVEC1302 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EV
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KII
H
LAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
T
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|656380.3.peg.3019
Escherichia coli FVEC1412 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EV
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KII
H
LAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
T
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|749549.3.peg.5226
Escherichia coli MS 198-1 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EV
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KII
H
LAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
T
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|585056.7.peg.2060
Escherichia coli UMN026 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EV
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KII
H
LAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
T
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|656437.3.peg.1799
Escherichia coli TA143 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LKEYGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KII
H
LAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
T
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|656437.3.peg.1800
Escherichia coli TA143 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LKEYGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KII
H
LAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
T
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|340185.3.peg.3274
Escherichia coli E22 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
R
PQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
G
K
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|340185.4.peg.3450
Escherichia coli E22 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
EA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
R
PQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
G
K
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|749527.3.peg.4300
Escherichia coli MS 21-1 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
ET
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
T
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
T
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|405955.13.peg.1671
Escherichia coli APEC O1 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
QA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
P
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
V
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|405955.9.peg.1356
Escherichia coli APEC O1 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
QA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
P
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
V
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|714962.3.peg.1739
Escherichia coli IHE3034 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
QA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
P
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
V
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|585035.6.peg.1626
Escherichia coli S88 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
QA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
P
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
V
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|869729.3.peg.1959
Escherichia coli UM146 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
QA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
P
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
V
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|364106.7.peg.1818
Escherichia coli UTI89 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
QA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
P
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
V
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|364106.8.peg.1821
Escherichia coli UTI89 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
QA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
P
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
V
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|585057.4.peg.1536
Escherichia coli IAI39 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
QA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GA
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
T
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|585057.6.peg.1536
Escherichia coli IAI39 (14-808/808)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
QA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
F
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GA
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
I
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
T
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|753642.3.peg.1575
Escherichia coli NC101 (4-798/798)
EISRR
S
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
QA
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
IT
S
IP
A
E
KIIQLA
L
EIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
L
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
P
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
S
E
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
V
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
fig|749537.3.peg.2398
Escherichia coli MS 115-1 (4-798/798)
EISRR
N
LMKT
S
A
L
G
S
LA
L
AS
S
AFTLPF
SQMVRA
A
ET
P
V
-
E---
EK
AV
W
--
SS
C
T
VNCGSRC
L
LRLHV
K
D
DT
V
YW
VE
S
D
T
TG
D
D
V
Y
-
GNHQVRACLRGRSIRRRMN
H
PDRL
K
YPMKRVGKRG
----
EGKFERISWDEA
L
D
T
I
SDNL
R
RI
LK
D
YGNEAV
H
V
L
YGT
-------
G
VD
GG
N
I
T
N
S
----
N
V
-
PY
RLMN
SC
GG
F
L
S
R
YG
S
YS
T
AQI
SA
A
MS
Y
M
FG
A-N
DGNS
PD
DI
A
N
T
KLVVMFGNNPAE
------
TRMSGGG
V
TY
YV
E
Q
ARE
R
SNA
R
MIV
-
IDPRY
N
DT
A
AGREDEWLPIRPGTD
G
AL
ACA
IA
W
VLI
T
EN
M
VDQ
P
FLDKYC
--------
VGYDEK
-
TLP
-----------
A
N
AP
R
N
-
A
HYKAYILGEG
P
D
GI
AKTPEWAA
K
I
I
S
IP
A
E
KIIQLAREIG
SA
KPA
Y
ICQGW
--
GPQRH
S
NGE
Q
TSRAI
A
ML
S
V
LTGNV
--------
GINGGNSG
---
V
RE
-
GS
W
DLGVE
W
V
P
---
M
L
E
NP
VK
T
Q
IS
V
F
T
WTDAI
DH
GT
-----------
EMTA
T
RDGVRGK
E
KLDVPIK
FL
W
C
YA
S
N
T
L
I
NQH
GD
IN
H
THE
V
L
---
QD
DS
KCE
M
IV
G
ID
H
FMT
A
SAKY
C
DILLPD
L
M
PT
EQED
LIS
H
ESA
GNM
G
Y
V
I
L
AQ
P
ATSAK
FE
R
K
P
IYW
M
LSE
V
AKRLGPDV
Y
Q
T
FTEGR
S
Q
H
E
W
I
K
Y
L
H
AK
TK
E
-----------
RN
PE
M
P
D
Y
-----------
EE
M
K
TT
GIFKKK
C
----------
P
E
E
H
Y
VA
FR
AFR
E
DPQANPL
K
TP
--
SGKIEIYS
ER
LA
K
IA
D
TWEL
K
KDE
--------------------
I
I
H
PLP
A
Y
TPG
F
D
GWDD
P
LRKT
YPLQL
T
GFHYK
A
R
T
H
--
S
S
YGNIDVL
QQ
ACPQEV
-
WINPIDAQARGI
RH
GD
T
VRVFN
N
N
GE
M
LIA
AKVTPR
IL
PGV
T
A
I
GQGAW
LK
A
D
M
FGDRV
D
H
GG
S
IN
I
LT
SH
RPSPLAKGNP
S
H
S
NLVQIEKV
Consen1
Primary consensus
MeiSRR
lmKttAig
lA
As
aftlPf
a
av
-
Ek
W
--
C
vnCGsrC
lrlhv
d
v
ve
D
tg
d
y
-
GnhqvraClrGrsirrrmn
pDRL
yPmkRvgkrG
----
EGkFerIsWdeA
D
i
k
lkeyGnEav
v
ygt
-------
G
gg
mt
s
n
-
rlmn
gg
ln
yg
ys
Aqi
a
ytfG
dgns
DIensklvVmfGnNpaE
------
tRmsggg
ty
e
aRe
SNa
miv
-
idprY
dt
agreDewlpirPgtD
al
iA
vlI
eN
vdQ
FldKyc
--------
vGYdek
-
TlP
-----------
AsaP
n
-
hYKAyilgeg
d
akTpewaaqiTgiP
dkiiqLAreig
kpa
IcqgW
--
GpqrhanGe
tsrai
mL
iLTGnv
--------
ginGgnSg
---
aRE
-
gsy
r
P
---
l
Np
t
Is
f
WtdaI
Gt
-----------
emtA
rDGvrgk
KLdVpik
W
ya
N
l
Nqh
iN
thE
l
---
qD
kce
Ivvid
fmT
SAkyaDilLPd
m
Eqed
n
gnm
y
if
p
fE
K
iyw
lse
akRlgpdv
q
ftegrtqe
W
k
L
Ak
e
-----------
Pelp
y
-----------
eE
k
Gifkkk
----------
p
gH
vA
aFrddpqAnpL
tP
--
sGKieiys
la
ia
tWel
kde
--------------------
vI
pLP
y
Fe
p
ypLqL
gfhyk
r
H
--
S
ygnidvL
Acpqev
-
wInPiDAqaRgi
GD
Vrvfn
rGEv
akvtpR
Pgv
a
gqGaw
a
m
D
gg
iN
LT
rpsPLaKgnp
h
nlVqiEKv
Consen2
Secondary consensus
k
fv
a
-
a
glsv
-
v
pip
a
dk
f
-
tg
vl
gt
q
i
cq
da
v
rd
ln
----
ik
yf
pki
y
k
q
ll
m
-
an
kydk
e
tp
t
eq
m
e
k
p
si
fssgqwtiwe
as
f
a
s
l
----
--
i
na
hc
sa
g
rmy
pmgc
aq
daf
lw
a
mg
mhpilws
itn
--
--
-
-
q
vtiavlst
hr
fela
ngiift
qs
vi
l
y
n
in
fs
hvnlrkgatdi
glrp
h
lekaaknpgsd
e
sf
d
fv
----
-
ey
lqkts
m
sv
e
lek
qlya
nkk
sy
-
tm
fnqq
r
v
a
nlv
n
kisqpgcgpfsl
qp
acgtv
vst
w
adm
v
e
r
c
k
n
--
pipakiglhavaqdr
k
----
n
---
mc
-
mq
p
ne
mpgwr
--
n
igse
p
lac
li
t
t
kmg
rtq
-
-
l
q
g
dle
tvq
sr
f
----
-
----
kseh
q
alrgktlyevly
a
s
fpvselaedqlnd
r
fyl
r
lfeeyawfgrg
e
l
p
deyh
rg
w
vvn
-----
--
-
e
q
ry
eg
dpyvkagegykfygkpdgkai
a
-
d
a
fd
w
tgrvl
h
tg
trrvpe
freamlf
h
l
kk
dl
kivs
n
m
vetrg
--
-
pe
lv
p
-
aq
v
atd
s
etd
k
ca
i
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character