fig|656379.3.peg.2719
Escherichia coli FVEC1302
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|656380.3.peg.2278
Escherichia coli FVEC1412
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|749549.3.peg.1844
Escherichia coli MS 198-1
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|585056.7.peg.2701
Escherichia coli UMN026
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|362663.8.peg.2242
Escherichia coli 536
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|362663.9.peg.2246
Escherichia coli 536
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|525281.3.peg.3989
Escherichia coli 83972
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|655817.3.peg.2632
Escherichia coli ABU 83972
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|199310.1.peg.2648
Escherichia coli CFT073
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|199310.4.peg.2561
Escherichia coli CFT073
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|340197.3.peg.244
Escherichia coli F11
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|340197.5.peg.254
Escherichia coli F11
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|749546.3.peg.2965
Escherichia coli MS 185-1
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|749550.3.peg.1753
Escherichia coli MS 200-1
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|749528.3.peg.2582
Escherichia coli MS 45-1
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|685038.3.peg.2244
Escherichia coli O83:H1 str. NRG 857C
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|216592.1.peg.2976
Escherichia coli 042
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|216592.3.peg.2524
Escherichia coli 042
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|562.371.peg.5044
Escherichia coli 1044A
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|562.373.peg.3933
Escherichia coli 1125A
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|562.372.peg.5585
Escherichia coli 1212A
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|562.374.peg.3333
Escherichia coli 536A
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|550676.3.peg.2482
Escherichia coli B185
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|550677.3.peg.1731
Escherichia coli B354
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|585057.4.peg.2418
Escherichia coli IAI39
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|585057.6.peg.2420
Escherichia coli IAI39
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|656417.3.peg.2858
Escherichia coli M605
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|656419.3.peg.2942
Escherichia coli M718
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|679205.4.peg.4646
Escherichia coli MS 124-1
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|749533.3.peg.324
Escherichia coli MS 84-1
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|83334.1.peg.3068
Escherichia coli O157:H7
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|155864.1.peg.3073
Escherichia coli O157:H7 EDL933
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|155864.8.peg.2965
Escherichia coli O157:H7 EDL933
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|444454.5.peg.1998
Escherichia coli O157:H7 str. EC4024
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|444449.5.peg.1460
Escherichia coli O157:H7 str. EC4042
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|444448.5.peg.221
Escherichia coli O157:H7 str. EC4045
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|444453.5.peg.1567
Escherichia coli O157:H7 str. EC4076
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|444452.5.peg.2586
Escherichia coli O157:H7 str. EC4113
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|444450.8.peg.3311
Escherichia coli O157:H7 str. EC4115
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|444451.5.peg.815
Escherichia coli O157:H7 str. EC4196
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|444447.5.peg.355
Escherichia coli O157:H7 str. EC4206
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|478006.5.peg.4211
Escherichia coli O157:H7 str. EC4501
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|478008.5.peg.4114
Escherichia coli O157:H7 str. EC869
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|637388.3.peg.399
Escherichia coli O157:H7 str. FRIK2000
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|570506.3.peg.4933
Escherichia coli O157:H7 str. FRIK966
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|386585.9.peg.3206
Escherichia coli O157:H7 str. Sakai
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|544404.4.peg.3114
Escherichia coli O157:H7 str. TW14359
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|502346.5.peg.4309
Escherichia coli O157:H7 str. TW14588
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|701177.3.peg.2749
Escherichia coli O55:H7 str. CB9615
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|439855.10.peg.2499
Escherichia coli SMS-3-5
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|749527.3.peg.177
Escherichia coli MS 21-1
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
T
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|405955.13.peg.2404
Escherichia coli APEC O1
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|405955.9.peg.1959
Escherichia coli APEC O1
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|216593.1.peg.2563
Escherichia coli E2348/69
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|585397.7.peg.2637
Escherichia coli ED1a
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|585397.9.peg.2634
Escherichia coli ED1a
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|656393.3.peg.3216
Escherichia coli H299
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|714962.3.peg.2464
Escherichia coli IHE3034
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|753642.3.peg.2906
Escherichia coli NC101
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|574521.7.peg.2382
Escherichia coli O127:H6 str. E2348/69
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|585035.6.peg.2311
Escherichia coli S88
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|431946.3.peg.2158
Escherichia coli SE15
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|869729.3.peg.1246
Escherichia coli UM146
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|364106.7.peg.2490
Escherichia coli UTI89
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|364106.8.peg.2491
Escherichia coli UTI89
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|562.376.peg.4106
Escherichia coli WV_060327
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|340186.3.peg.1290
Escherichia coli E110019
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
S
S
SIL
FC
LYASRPKKR
fig|340186.5.peg.1338
Escherichia coli E110019
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
S
S
SIL
FC
LYASRPKKR
fig|562.375.peg.3168
Escherichia coli EC4100B
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
S
S
SIL
FC
LYASRPKKR
fig|409438.11.peg.2607
Escherichia coli SE11
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
S
S
SIL
FC
LYASRPKKR
fig|478007.5.peg.4969
Escherichia coli O157:H7 str. EC508
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
L
M
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|670897.3.peg.3160
Escherichia coli 2362-75
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVV
I
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|656437.3.peg.2455
Escherichia coli TA143
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
A
GL
WIQF
M
V
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|656444.3.peg.3176
Escherichia coli TA280
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
A
GL
WIQF
M
V
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|656440.3.peg.2171
Escherichia coli TA206
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAQ
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
V
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
L
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
I
S
SIL
FC
LYASRPKKR
fig|1040638.4.peg.3265
Escherichia coli O104:H4 str. LB226692
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|6666666.5357.peg.532
Escherichia coli TY-2482
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|358709.5.peg.631
Escherichia coli 101-1
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|670888.3.peg.4096
Escherichia coli 1827-70
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|344610.3.peg.1741
Escherichia coli 53638
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|344610.7.peg.4247
Escherichia coli 53638
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|585055.6.peg.2471
Escherichia coli 55989
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|585055.8.peg.2477
Escherichia coli 55989
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|481805.3.peg.1570
Escherichia coli ATCC 8739
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|481805.6.peg.1562
Escherichia coli ATCC 8739
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|413997.3.peg.2206
Escherichia coli B str. REL606
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|340184.3.peg.423
Escherichia coli B7A
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
T
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|340184.6.peg.441
Escherichia coli B7A
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
T
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|511693.5.peg.2217
Escherichia coli BL21
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|469008.4.peg.1517
Escherichia coli BL21(DE3)
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|595496.3.peg.2152
Escherichia coli BW2952
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|536056.3.peg.1550
Escherichia coli DH1
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|331111.12.peg.2767
Escherichia coli E24377A
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|331111.3.peg.223
Escherichia coli E24377A
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|656414.3.peg.2555
Escherichia coli H736
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|331112.3.peg.2178
Escherichia coli HS
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|331112.6.peg.2277
Escherichia coli HS
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|83333.1.peg.2157
Escherichia coli K12
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|679207.4.peg.4058
Escherichia coli MS 107-1
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|749537.3.peg.2471
Escherichia coli MS 115-1
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|749538.3.peg.3250
Escherichia coli MS 116-1
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|679204.3.peg.218
Escherichia coli MS 145-7
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
T
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|749540.3.peg.836
Escherichia coli MS 146-1
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|749548.3.peg.2185
Escherichia coli MS 196-1
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|316407.3.peg.2116
Escherichia coli W3110
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|316385.5.peg.2305
Escherichia coli str. K-12 substr. DH10B
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|316385.7.peg.2360
Escherichia coli str. K-12 substr. DH10B
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|511145.12.peg.2270
Escherichia coli str. K-12 substr. MG1655
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|511145.6.peg.2254
Escherichia coli str. K-12 substr. MG1655
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|316401.4.peg.2653
Escherichia coli ETEC H10407
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AV
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|749547.3.peg.2619
Escherichia coli MS 187-1
MTTRQHSSFAIVF
L
LGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|749531.3.peg.1959
Escherichia coli MS 69-1
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
G
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FC
LYASRPKKR
fig|550672.3.peg.1901
Escherichia coli B088
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
S
S
SIL
FC
LYASRPKKR
fig|344601.3.peg.1419
Escherichia coli B171
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
S
S
SIL
FC
LYASRPKKR
fig|344601.5.peg.1495
Escherichia coli B171
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
S
S
SIL
FC
LYASRPKKR
fig|679206.4.peg.2409
Escherichia coli MS 119-7
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
S
S
SIL
FC
LYASRPKKR
fig|749544.3.peg.2555
Escherichia coli MS 175-1
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
S
S
SIL
FC
LYASRPKKR
fig|749545.3.peg.4093
Escherichia coli MS 182-1
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
S
S
SIL
FC
LYASRPKKR
fig|585395.4.peg.2783
Escherichia coli O103:H2 str. 12009
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
S
S
SIL
FC
LYASRPKKR
fig|585396.4.peg.3000
Escherichia coli O111:H- str. 11128
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
S
S
SIL
FC
LYASRPKKR
fig|573235.3.peg.3167
Escherichia coli O26:H11 str. 11368
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
S
S
SIL
FC
LYASRPKKR
fig|656443.3.peg.2892
Escherichia coli TA271
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
S
S
SIL
FC
LYASRPKKR
fig|749532.3.peg.3467
Escherichia coli MS 78-1
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
L
V
TFNSA
W
P
M
I
W
SI
AF
-
C
A
S
S
SIL
FC
LYASRPKKR
fig|656408.3.peg.2433
Escherichia coli H591
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
C
SI
AF
-
C
A
S
S
SIL
FC
LYASRPKKR
fig|585034.4.peg.2234
Escherichia coli IAI1
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FY
LYASRPKKR
fig|585034.5.peg.2231
Escherichia coli IAI1
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FY
LYASRPKKR
fig|595495.4.peg.251
Escherichia coli KO11
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FY
LYASRPKKR
fig|566546.3.peg.1446
Escherichia coli W
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FY
LYASRPKKR
fig|566546.4.peg.2364
Escherichia coli W
MTTRQHSSFAIVFILGLLA
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
TQ
M
TLS
TY
I
L
GFA
L
GQL
I
YGP
MA
D
SF
GRK
-
PVVL
G
G
T
LVFA
AA
A
V
A
CA
LAN
T
I
DQ
L
I
V
M
RF
F
H
GLA
A
AAASVV
IN
AL
M
RD
I
YP
KEEF
SR
M
MS
F
VM
L
V
T
TI
AP
L
M
API
V
GGWVLV
W
L
SW
HY
IFW
I
LA
L
A
A
I
LA
S
A
M
IF
F
LI
K
ETLP
P
E
R
RQ
PF
H
IR
T
T
IGNF
AA
L
F
RHKR
VLSYM
L
A
SG
F
SF
AG
M
F
S
FL
SA
G
PFV
Y
I
E
IN
H
V
A
P
EN
F
GY
Y
F
A
LN
-
I
V
F
L
F
VM
TI
F
N
SR
FV
RRI
G
AL
NMF
R
S
GL
WIQF
I
M
A
A
W
M
V
I
S
A
LLG
L
GF
W
S
LV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
LA
TFNSA
W
P
M
I
W
SI
AF
-
C
A
T
S
SIL
FY
LYASRPKKR
fig|444454.5.peg.119
Escherichia coli O157:H7 str. EC4024 (1-376/380)
M
L
M
PL
S
I
DMYLPALP
V
ISAQ
F
GV
PA
GS
A
Q
M
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L
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L
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F
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MA
D
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AA
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V
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IN
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M
RD
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YP
KEEF
SR
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MS
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AP
L
V
AP
M
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LA
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IF
V
F
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T
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AS
L
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L
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SG
F
SF
AG
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FL
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G
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Y
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LN
H
V
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F
GY
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-
I
V
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L
F
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TI
I
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SR
FV
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V
G
AL
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R
A
GL
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V
M
A
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W
L
VL
S
A
LLG
V
GF
WALV
-----
V
G
V
A
A
F
VG
--------
CV
SMVS
S
N
-------
AM
-----
A
VI
L
DE
FPH
M
AGTAS
S
L
A
GT
FR
FG
I
G
A
I
VGA
L
LS
M
A
TFNTA
W
P
M
L
W
A
I
AL
-
C
A
T
C
SIL
FY
LYASRP
R
K
fig|656440.3.peg.1205
Escherichia coli TA206 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
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F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RG
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
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IAAI
L
C
A
L
L
T
VL
C
A
WVQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
S--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|525281.3.peg.126
Escherichia coli 83972 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WIQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|655817.3.peg.1655
Escherichia coli ABU 83972 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WIQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|199310.1.peg.1713
Escherichia coli CFT073 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WIQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|199310.4.peg.1642
Escherichia coli CFT073 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WIQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|749546.3.peg.268
Escherichia coli MS 185-1 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
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F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WIQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|749527.3.peg.413
Escherichia coli MS 21-1 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WIQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|749528.3.peg.174
Escherichia coli MS 45-1 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WIQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|656444.3.peg.2025
Escherichia coli TA280 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WIQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|656393.3.peg.2065
Escherichia coli H299 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FIRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WIQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|670897.3.peg.2456
Escherichia coli 2362-75 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WVQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|362663.8.peg.1358
Escherichia coli 536 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WVQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|362663.9.peg.1358
Escherichia coli 536 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WVQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|405955.13.peg.1408
Escherichia coli APEC O1 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WVQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|405955.9.peg.1158
Escherichia coli APEC O1 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WVQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|216593.1.peg.1929
Escherichia coli E2348/69 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WVQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|340197.3.peg.1123
Escherichia coli F11 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WVQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|340197.5.peg.1184
Escherichia coli F11 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WVQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|714962.3.peg.1534
Escherichia coli IHE3034 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WVQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|749550.3.peg.64
Escherichia coli MS 200-1 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WVQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|574521.7.peg.1511
Escherichia coli O127:H6 str. E2348/69 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WVQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|685038.3.peg.1337
Escherichia coli O83:H1 str. NRG 857C (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WVQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|585035.6.peg.1425
Escherichia coli S88 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WVQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|869729.3.peg.2188
Escherichia coli UM146 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WVQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|364106.7.peg.1605
Escherichia coli UTI89 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WVQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|364106.8.peg.1605
Escherichia coli UTI89 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WVQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|562.376.peg.3161
Escherichia coli WV_060327 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WVQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|585397.7.peg.1509
Escherichia coli ED1a (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
M
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WVQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|585397.9.peg.1503
Escherichia coli ED1a (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
M
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WVQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|550677.3.peg.2755
Escherichia coli B354 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
N
P
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WIQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|749531.3.peg.292
Escherichia coli MS 69-1 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
N
P
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WIQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|585057.4.peg.1714
Escherichia coli IAI39 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|585057.6.peg.1714
Escherichia coli IAI39 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|439855.10.peg.1992
Escherichia coli SMS-3-5 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|431946.3.peg.1321
Escherichia coli SE15 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
H
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
T
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WIQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|753642.3.peg.1819
Escherichia coli NC101 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
CL
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
ILL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WVQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
I
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
L
L
VA
L
fig|562.371.peg.1410
Escherichia coli 1044A (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
C
V
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
F
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
F
L
VA
L
fig|562.373.peg.5237
Escherichia coli 1125A (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
C
V
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
F
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
F
L
VA
L
fig|562.372.peg.865
Escherichia coli 1212A (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
C
V
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
F
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
F
L
VA
L
fig|562.374.peg.6092
Escherichia coli 536A (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
C
V
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
F
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
F
L
VA
L
fig|550676.3.peg.850
Escherichia coli B185 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
C
V
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
F
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
F
L
VA
L
fig|656419.3.peg.1642
Escherichia coli M718 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
C
V
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
F
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
F
L
VA
L
fig|83334.1.peg.1901
Escherichia coli O157:H7 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
C
V
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
F
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
F
L
VA
L
fig|444454.5.peg.263
Escherichia coli O157:H7 str. EC4024 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
C
V
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
F
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
F
L
VA
L
fig|444449.5.peg.162
Escherichia coli O157:H7 str. EC4042 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
C
V
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
F
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
F
L
VA
L
fig|444448.5.peg.4518
Escherichia coli O157:H7 str. EC4045 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
C
V
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
F
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
F
L
VA
L
fig|444453.5.peg.5297
Escherichia coli O157:H7 str. EC4076 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
C
V
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
F
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
F
L
VA
L
fig|444452.5.peg.2105
Escherichia coli O157:H7 str. EC4113 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
C
V
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
F
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
F
L
VA
L
fig|444450.8.peg.1981
Escherichia coli O157:H7 str. EC4115 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
C
V
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
F
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
F
L
VA
L
fig|444451.5.peg.2725
Escherichia coli O157:H7 str. EC4196 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
C
V
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
F
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
F
L
VA
L
fig|444447.5.peg.5427
Escherichia coli O157:H7 str. EC4206 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
C
V
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
F
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
F
L
VA
L
fig|478004.5.peg.2711
Escherichia coli O157:H7 str. EC4401 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
C
V
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
F
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
F
L
VA
L
fig|478005.5.peg.3292
Escherichia coli O157:H7 str. EC4486 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
C
V
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
F
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
F
L
VA
L
fig|478006.5.peg.3136
Escherichia coli O157:H7 str. EC4501 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
C
V
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
F
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
F
L
VA
L
fig|478007.5.peg.2330
Escherichia coli O157:H7 str. EC508 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
C
V
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
F
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
F
L
VA
L
fig|478008.5.peg.3576
Escherichia coli O157:H7 str. EC869 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
C
V
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
F
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
F
L
VA
L
fig|637388.3.peg.1353
Escherichia coli O157:H7 str. FRIK2000 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
C
V
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
F
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
F
L
VA
L
fig|570506.3.peg.3359
Escherichia coli O157:H7 str. FRIK966 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
C
V
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
F
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
F
L
VA
L
fig|386585.9.peg.1968
Escherichia coli O157:H7 str. Sakai (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
C
V
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
F
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
F
L
VA
L
fig|544404.4.peg.1842
Escherichia coli O157:H7 str. TW14359 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
C
V
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
F
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
F
L
VA
L
fig|502346.5.peg.5509
Escherichia coli O157:H7 str. TW14588 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
C
V
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
F
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
F
L
VA
L
fig|701177.3.peg.1627
Escherichia coli O55:H7 str. CB9615 (5-380/387)
S
LSWAL
ILGLLA
G
I
GP
M
C
TD
L
YLPALP
E
M
S
E
QL
AA
TT
TI
TQ
L
TL
T
AS
L
I
G
LG
V
GQLL
F
GPLSD
KI
GRK
R
P
L
I
L
-
S
LL
L
F
I
VS
S
I
L
CA
TTN
NI
YW
L
V
V
W
RF
I
QG
I
A
G
A
GG
SV
L
SR
SI
A
RD
K
Y
Q
GVTL
T
Q
F
FA
L
L
M
T
V
N
GLAP
V
L
S
P
V
LGG
Y
I
VS
T
F
D
W
RT
L
FW
V
M
A
E
I
S
T
VL
L
L
G
C
V
L
F
I
N
ETLP
E
N
K
R
G
SS
L
LL
T
G
----
RS
V
V
Q
N
R
R
FMRFC
LI
QS
F
ML
AG
L
FA
Y
I
GS
S
S
FVL
Q
K
EF
G
F
SP
MQ
F
SL
VFGLN
-
G
I
G
L
I
IA
SW
I
F
SR
LA
RRI
N
A
M
TLL
RGGL
IAAI
L
C
A
L
L
T
VL
C
A
WTQ
L
PI
P
ALV
ALFFT
I
A
F
C
S
G
I
G
--------
T
V
G--G
A
E
-------
AM
-----
S
AV
G
TQ
---
E
S
GTASAL
M
G
M
SM
F
V
F
G
G
I
AAP
L
SG
F
G
G-ETL
L
K
MS
L
A
I
TV
-
C
Y
T
L
A
F
L
VA
L
fig|656444.3.peg.2563
Escherichia coli TA280 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
L
V
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|216592.1.peg.1191
Escherichia coli 042 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|216592.3.peg.1902
Escherichia coli 042 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|550677.3.peg.3047
Escherichia coli B354 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|562.375.peg.1769
Escherichia coli EC4100B (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|656379.3.peg.2135
Escherichia coli FVEC1302 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|656380.3.peg.3097
Escherichia coli FVEC1412 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|656393.3.peg.2456
Escherichia coli H299 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|656408.3.peg.1812
Escherichia coli H591 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|679206.4.peg.1233
Escherichia coli MS 119-7 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|749549.3.peg.5189
Escherichia coli MS 198-1 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|749527.3.peg.3549
Escherichia coli MS 21-1 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|656437.3.peg.1882
Escherichia coli TA143 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|656443.3.peg.2323
Escherichia coli TA271 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|585056.7.peg.2137
Escherichia coli UMN026 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|550676.3.peg.1968
Escherichia coli B185 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AM
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
I
T
T
T
S
V
M
L
fig|562.371.peg.4513
Escherichia coli 1044A (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AM
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|562.373.peg.5415
Escherichia coli 1125A (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AM
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|562.372.peg.4746
Escherichia coli 1212A (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AM
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|562.374.peg.4366
Escherichia coli 536A (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AM
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|83334.1.peg.2395
Escherichia coli O157:H7 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AM
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|155864.1.peg.2404
Escherichia coli O157:H7 EDL933 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AM
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|155864.8.peg.2250
Escherichia coli O157:H7 EDL933 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AM
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|444454.5.peg.1112
Escherichia coli O157:H7 str. EC4024 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AM
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|444449.5.peg.598
Escherichia coli O157:H7 str. EC4042 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AM
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|444448.5.peg.4905
Escherichia coli O157:H7 str. EC4045 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AM
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|444453.5.peg.5184
Escherichia coli O157:H7 str. EC4076 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AM
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|444452.5.peg.5197
Escherichia coli O157:H7 str. EC4113 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AM
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|444450.8.peg.2416
Escherichia coli O157:H7 str. EC4115 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AM
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|444451.5.peg.5527
Escherichia coli O157:H7 str. EC4196 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AM
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|444447.5.peg.5084
Escherichia coli O157:H7 str. EC4206 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AM
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|478004.5.peg.5360
Escherichia coli O157:H7 str. EC4401 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AM
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|478006.5.peg.5596
Escherichia coli O157:H7 str. EC4501 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AM
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|637388.3.peg.4978
Escherichia coli O157:H7 str. FRIK2000 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AM
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|570506.3.peg.4254
Escherichia coli O157:H7 str. FRIK966 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AM
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|386585.9.peg.2481
Escherichia coli O157:H7 str. Sakai (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AM
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|544404.4.peg.2279
Escherichia coli O157:H7 str. TW14359 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AM
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|502346.5.peg.5034
Escherichia coli O157:H7 str. TW14588 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AM
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|701177.3.peg.2056
Escherichia coli O55:H7 str. CB9615 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AM
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|358709.5.peg.4862
Escherichia coli 101-1 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|670888.3.peg.158
Escherichia coli 1827-70 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|344610.3.peg.3121
Escherichia coli 53638 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|344610.7.peg.5312
Escherichia coli 53638 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|585055.6.peg.1857
Escherichia coli 55989 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|585055.8.peg.1861
Escherichia coli 55989 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|481805.3.peg.2122
Escherichia coli ATCC 8739 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|481805.6.peg.2117
Escherichia coli ATCC 8739 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|413997.3.peg.1706
Escherichia coli B str. REL606 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|344601.3.peg.408
Escherichia coli B171 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|344601.5.peg.406
Escherichia coli B171 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|340184.3.peg.938
Escherichia coli B7A (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|340184.6.peg.973
Escherichia coli B7A (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|511693.5.peg.1733
Escherichia coli BL21 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|469008.4.peg.2043
Escherichia coli BL21(DE3) (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|340185.3.peg.3350
Escherichia coli E22 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|340185.4.peg.3526
Escherichia coli E22 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|331111.12.peg.2157
Escherichia coli E24377A (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|331111.3.peg.4300
Escherichia coli E24377A (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|316401.4.peg.1947
Escherichia coli ETEC H10407 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|331112.3.peg.1638
Escherichia coli HS (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|331112.6.peg.1705
Escherichia coli HS (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|585034.4.peg.1697
Escherichia coli IAI1 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|585034.5.peg.1692
Escherichia coli IAI1 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|595495.4.peg.4292
Escherichia coli KO11 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|656419.3.peg.2371
Escherichia coli M718 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|679207.4.peg.4517
Escherichia coli MS 107-1 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|749537.3.peg.1737
Escherichia coli MS 115-1 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|679205.4.peg.1699
Escherichia coli MS 124-1 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|679204.3.peg.583
Escherichia coli MS 145-7 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|749540.3.peg.4072
Escherichia coli MS 146-1 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|749545.3.peg.2755
Escherichia coli MS 182-1 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|749547.3.peg.3029
Escherichia coli MS 187-1 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|749548.3.peg.3406
Escherichia coli MS 196-1 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|749531.3.peg.4905
Escherichia coli MS 69-1 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|749532.3.peg.1458
Escherichia coli MS 78-1 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|749533.3.peg.2618
Escherichia coli MS 84-1 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|585395.4.peg.1886
Escherichia coli O103:H2 str. 12009 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|585396.4.peg.2213
Escherichia coli O111:H- str. 11128 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|573235.3.peg.2428
Escherichia coli O26:H11 str. 11368 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|637912.3.peg.4566
Escherichia coli OP50 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|409438.11.peg.1931
Escherichia coli SE11 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|566546.3.peg.985
Escherichia coli W (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|566546.4.peg.1816
Escherichia coli W (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|595496.3.peg.1622
Escherichia coli BW2952 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
A
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|536056.3.peg.2092
Escherichia coli DH1 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
A
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|316407.3.peg.1618
Escherichia coli W3110 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
A
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|316385.7.peg.1819
Escherichia coli str. K-12 substr. DH10B (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
A
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|511145.12.peg.1733
Escherichia coli str. K-12 substr. MG1655 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
A
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|511145.6.peg.1717
Escherichia coli str. K-12 substr. MG1655 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
A
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|83333.1.peg.1646
Escherichia coli K12 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
A
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|340186.3.peg.4829
Escherichia coli E110019 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
T
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|340186.5.peg.5091
Escherichia coli E110019 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
T
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|670897.3.peg.2257
Escherichia coli 2362-75 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|216593.1.peg.436
Escherichia coli E2348/69 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|585057.4.peg.1460
Escherichia coli IAI39 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|585057.6.peg.1459
Escherichia coli IAI39 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|362663.8.peg.1623
Escherichia coli 536 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LL
I
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|362663.9.peg.1627
Escherichia coli 536 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LL
I
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|525281.3.peg.842
Escherichia coli 83972 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LL
I
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|655817.3.peg.2004
Escherichia coli ABU 83972 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LL
I
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|405955.13.peg.1748
Escherichia coli APEC O1 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LL
I
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|405955.9.peg.1424
Escherichia coli APEC O1 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LL
I
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|199310.1.peg.1992
Escherichia coli CFT073 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LL
I
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|199310.4.peg.1923
Escherichia coli CFT073 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LL
I
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|340197.3.peg.3535
Escherichia coli F11 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LL
I
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|340197.5.peg.3696
Escherichia coli F11 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LL
I
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|656417.3.peg.2161
Escherichia coli M605 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LL
I
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|749546.3.peg.4557
Escherichia coli MS 185-1 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LL
I
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|749550.3.peg.3212
Escherichia coli MS 200-1 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LL
I
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|749528.3.peg.4877
Escherichia coli MS 45-1 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LL
I
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|753642.3.peg.3305
Escherichia coli NC101 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LL
I
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|585035.6.peg.1702
Escherichia coli S88 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LL
I
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|431946.3.peg.1583
Escherichia coli SE15 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LL
I
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|656440.3.peg.1513
Escherichia coli TA206 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LL
I
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|869729.3.peg.1877
Escherichia coli UM146 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LL
I
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|364106.7.peg.1894
Escherichia coli UTI89 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LL
I
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|364106.8.peg.1897
Escherichia coli UTI89 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LL
I
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|562.376.peg.2888
Escherichia coli WV_060327 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LL
I
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|6666666.5357.peg.1862
Escherichia coli TY-2482 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
L
A
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|714962.3.peg.1815
Escherichia coli IHE3034 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LL
I
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
M
M
L
fig|749538.3.peg.4640
Escherichia coli MS 116-1 (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
L
V
L
L
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LLV
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
R
S
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|585397.7.peg.1882
Escherichia coli ED1a (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LL
I
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
HS
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|585397.9.peg.1877
Escherichia coli ED1a (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LL
I
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
HS
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|685038.3.peg.1678
Escherichia coli O83:H1 str. NRG 857C (11-369/403)
L
AG
L
S
V
LG
F
L
A
TDMYLPA
FA
A
I
Q
A
D
L
QT
PA
SA
VS
A
S
LS
LF
L
A
GFA
A
A
QLL
W
GPLSD
RY
GRK
-
PV
L
F
I
GL
T
I
FA
LG
S
L
G
ML
WVE
N
A
AT
LL
I
L
RF
V
Q
A
V
G
V
C
AA
A
V
I
WQ
AL
V
T
D
Y
YP
SQKV
N
R
I
FA
T
I
M
P
L
V
GL
S
P
A
LAP
L
LG
S
W
L
LV
H
FSW
QA
IF
A
T
L
F
A
I
T
V
VL
I
L
P
IF
W
L
K
P
T
T
KA
R
N
N
S
Q
DG
L
TF
T
D
----
--
L
L
HS
K
T
YRGNV
LI
YA
A
CS
A
S
F
FA
W
L
TG
SPF
I
L
S
E
M-
G
Y
SP
A-
-
--
V
I
GL
S
-
Y
V
P
Q
T
IA
FL
I
G
GY
GC
R
--
A
AL
QKW
Q
G
--
--KQ
L
L
P
W
L
L
VL
F
A
VSV
I
AT
WA
--
-----
A
GF
I
S
H
V
SLVEILIPF
CV
MAIA
N
G
-------
A
IYPIVV
A
QA
L
RP
FPH
A
T
G
R
A
A
AL
Q
N
T
LQ
L
G
-
-
-
-
---
L
CF
LA
SLVVS
W
L
I
S
I
S
T
PL
-
L
T
T
T
S
V
M
L
fig|701177.3.peg.4523
Escherichia coli O55:H7 str. CB9615 (11-376/391)
L
V
L
L
Y
P
A
G
I
DMYL
VG
LP
R
I
A
A
D
L
NA
SE
AQ
LH
I
AF
S
VY
L
A
G
M
A
A
A
M
L
FA
G
K
V
A
D
RS
GRK
-
PV
A
I
P
G
AA
L
F
I
IA
SV
F
C
S
LAE
T
S
TL
F
L
A
G
RF
L
QGL
G
A
GCCY
VV
AF
A
I
L
RD
T
LD
DRRR
AK
V
L
S
L
L
N
G
I
T
C
I
I
P
V
LAP
V
LG
HL
IML
K
F
P
W
QS
L
FW
T
M
A
I
M
G
I
A
V
L
M
L
S
L
F
IL
K
ET
R
P
A
A
P
AA
SD
K
SR
E
N
----
SE
S
L
L
N
R
F
FLSRV
V
I
TT
L
SV
S
V
I
LT
F
V
NT
SP
V
L
L
M
E
IM
G
F
ER
GE
Y
AT
I
M
A
L
TA
G
V
S
M
T
V
S
F-
-
-
--
--
STP
F
AL
GIF
K
P
--
----
-
-
R
T
L
M
I
T
S
Q
VLF
L
A-
--
--
-----
A
G
I
T
L
T
V
S
PSHAVSL
F
G
I
TLIC
A
G
FSVGFGV
AM
-----
S
QA
L
GP
F
SL
R
AG
V
AS
S
T
L
G
I
AQ
VC
G
S
S
L
WIW
L
AA
V
V
G-ISA
W
N
M
L
I
G
I
LI
A
C
S
I
V
S
L
L
LI
MFVA
fig|562.371.peg.3015
Escherichia coli 1044A (11-376/391)
L
V
L
L
Y
P
A
G
I
DMYL
VG
LP
R
I
A
A
D
L
NA
SE
AQ
LH
I
AF
S
VY
L
A
G
M
A
A
A
M
L
FA
G
K
V
A
D
RS
GRK
-
PV
A
I
P
G
AA
L
F
I
IT
SV
F
C
S
LAE
T
S
TL
F
L
A
G
RF
L
QGL
G
A
GCCY
VV
AF
A
I
L
RD
T
LD
DRRR
AK
V
L
S
L
L
N
G
I
T
C
I
I
P
V
LAP
V
LG
HL
IML
K
F
P
W
QS
L
FW
T
M
A
I
M
G
I
A
V
L
M
L
S
L
F
IL
K
ET
R
P
A
A
P
AA
SD
K
SR
E
N
----
SE
S
L
L
N
R
F
FLSRV
V
I
TT
L
SV
S
V
I
LT
F
V
NT
SP
V
L
L
M
E
IM
G
F
ER
GE
Y
AT
I
M
A
L
TA
G
V
S
M
T
V
S
F-
-
-
--
--
STP
F
AL
GIF
K
P
--
----
-
-
R
T
L
M
I
T
S
Q
VLF
L
A-
--
--
-----
A
G
I
T
L
T
V
S
PSHAVSL
F
G
I
TLIC
A
G
FSVGFGV
AM
-----
S
QA
L
GP
F
SL
R
AG
V
AS
S
T
L
G
I
AQ
VC
G
S
S
L
WIW
L
AA
V
V
G-ISA
W
N
M
L
I
G
I
LI
A
C
S
I
V
S
L
L
LI
MFVA
fig|562.373.peg.942
Escherichia coli 1125A (11-376/391)
L
V
L
L
Y
P
A
G
I
DMYL
VG
LP
R
I
A
A
D
L
NA
SE
AQ
LH
I
AF
S
VY
L
A
G
M
A
A
A
M
L
FA
G
K
V
A
D
RS
GRK
-
PV
A
I
P
G
AA
L
F
I
IT
SV
F
C
S
LAE
T
S
TL
F
L
A
G
RF
L
QGL
G
A
GCCY
VV
AF
A
I
L
RD
T
LD
DRRR
AK
V
L
S
L
L
N
G
I
T
C
I
I
P
V
LAP
V
LG
HL
IML
K
F
P
W
QS
L
FW
T
M
A
I
M
G
I
A
V
L
M
L
S
L
F
IL
K
ET
R
P
A
A
P
AA
SD
K
SR
E
N
----
SE
S
L
L
N
R
F
FLSRV
V
I
TT
L
SV
S
V
I
LT
F
V
NT
SP
V
L
L
M
E
IM
G
F
ER
GE
Y
AT
I
M
A
L
TA
G
V
S
M
T
V
S
F-
-
-
--
--
STP
F
AL
GIF
K
P
--
----
-
-
R
T
L
M
I
T
S
Q
VLF
L
A-
--
--
-----
A
G
I
T
L
T
V
S
PSHAVSL
F
G
I
TLIC
A
G
FSVGFGV
AM
-----
S
QA
L
GP
F
SL
R
AG
V
AS
S
T
L
G
I
AQ
VC
G
S
S
L
WIW
L
AA
V
V
G-ISA
W
N
M
L
I
G
I
LI
A
C
S
I
V
S
L
L
LI
MFVA
fig|562.372.peg.3900
Escherichia coli 1212A (11-376/391)
L
V
L
L
Y
P
A
G
I
DMYL
VG
LP
R
I
A
A
D
L
NA
SE
AQ
LH
I
AF
S
VY
L
A
G
M
A
A
A
M
L
FA
G
K
V
A
D
RS
GRK
-
PV
A
I
P
G
AA
L
F
I
IT
SV
F
C
S
LAE
T
S
TL
F
L
A
G
RF
L
QGL
G
A
GCCY
VV
AF
A
I
L
RD
T
LD
DRRR
AK
V
L
S
L
L
N
G
I
T
C
I
I
P
V
LAP
V
LG
HL
IML
K
F
P
W
QS
L
FW
T
M
A
I
M
G
I
A
V
L
M
L
S
L
F
IL
K
ET
R
P
A
A
P
AA
SD
K
SR
E
N
----
SE
S
L
L
N
R
F
FLSRV
V
I
TT
L
SV
S
V
I
LT
F
V
NT
SP
V
L
L
M
E
IM
G
F
ER
GE
Y
AT
I
M
A
L
TA
G
V
S
M
T
V
S
F-
-
-
--
--
STP
F
AL
GIF
K
P
--
----
-
-
R
T
L
M
I
T
S
Q
VLF
L
A-
--
--
-----
A
G
I
T
L
T
V
S
PSHAVSL
F
G
I
TLIC
A
G
FSVGFGV
AM
-----
S
QA
L
GP
F
SL
R
AG
V
AS
S
T
L
G
I
AQ
VC
G
S
S
L
WIW
L
AA
V
V
G-ISA
W
N
M
L
I
G
I
LI
A
C
S
I
V
S
L
L
LI
MFVA
fig|562.374.peg.1989
Escherichia coli 536A (11-376/391)
L
V
L
L
Y
P
A
G
I
DMYL
VG
LP
R
I
A
A
D
L
NA
SE
AQ
LH
I
AF
S
VY
L
A
G
M
A
A
A
M
L
FA
G
K
V
A
D
RS
GRK
-
PV
A
I
P
G
AA
L
F
I
IT
SV
F
C
S
LAE
T
S
TL
F
L
A
G
RF
L
QGL
G
A
GCCY
VV
AF
A
I
L
RD
T
LD
DRRR
AK
V
L
S
L
L
N
G
I
T
C
I
I
P
V
LAP
V
LG
HL
IML
K
F
P
W
QS
L
FW
T
M
A
I
M
G
I
A
V
L
M
L
S
L
F
IL
K
ET
R
P
A
A
P
AA
SD
K
SR
E
N
----
SE
S
L
L
N
R
F
FLSRV
V
I
TT
L
SV
S
V
I
LT
F
V
NT
SP
V
L
L
M
E
IM
G
F
ER
GE
Y
AT
I
M
A
L
TA
G
V
S
M
T
V
S
F-
-
-
--
--
STP
F
AL
GIF
K
P
--
----
-
-
R
T
L
M
I
T
S
Q
VLF
L
A-
--
--
-----
A
G
I
T
L
T
V
S
PSHAVSL
F
G
I
TLIC
A
G
FSVGFGV
AM
-----
S
QA
L
GP
F
SL
R
AG
V
AS
S
T
L
G
I
AQ
VC
G
S
S
L
WIW
L
AA
V
V
G-ISA
W
N
M
L
I
G
I
LI
A
C
S
I
V
S
L
L
LI
MFVA
fig|83334.1.peg.4618
Escherichia coli O157:H7 (11-376/391)
L
V
L
L
Y
P
A
G
I
DMYL
VG
LP
R
I
A
A
D
L
NA
SE
AQ
LH
I
AF
S
VY
L
A
G
M
A
A
A
M
L
FA
G
K
V
A
D
RS
GRK
-
PV
A
I
P
G
AA
L
F
I
IT
SV
F
C
S
LAE
T
S
TL
F
L
A
G
RF
L
QGL
G
A
GCCY
VV
AF
A
I
L
RD
T
LD
DRRR
AK
V
L
S
L
L
N
G
I
T
C
I
I
P
V
LAP
V
LG
HL
IML
K
F
P
W
QS
L
FW
T
M
A
I
M
G
I
A
V
L
M
L
S
L
F
IL
K
ET
R
P
A
A
P
AA
SD
K
SR
E
N
----
SE
S
L
L
N
R
F
FLSRV
V
I
TT
L
SV
S
V
I
LT
F
V
NT
SP
V
L
L
M
E
IM
G
F
ER
GE
Y
AT
I
M
A
L
TA
G
V
S
M
T
V
S
F-
-
-
--
--
STP
F
AL
GIF
K
P
--
----
-
-
R
T
L
M
I
T
S
Q
VLF
L
A-
--
--
-----
A
G
I
T
L
T
V
S
PSHAVSL
F
G
I
TLIC
A
G
FSVGFGV
AM
-----
S
QA
L
GP
F
SL
R
AG
V
AS
S
T
L
G
I
AQ
VC
G
S
S
L
WIW
L
AA
V
V
G-ISA
W
N
M
L
I
G
I
LI
A
C
S
I
V
S
L
L
LI
MFVA
fig|155864.1.peg.4654
Escherichia coli O157:H7 EDL933 (11-376/391)
L
V
L
L
Y
P
A
G
I
DMYL
VG
LP
R
I
A
A
D
L
NA
SE
AQ
LH
I
AF
S
VY
L
A
G
M
A
A
A
M
L
FA
G
K
V
A
D
RS
GRK
-
PV
A
I
P
G
AA
L
F
I
IT
SV
F
C
S
LAE
T
S
TL
F
L
A
G
RF
L
QGL
G
A
GCCY
VV
AF
A
I
L
RD
T
LD
DRRR
AK
V
L
S
L
L
N
G
I
T
C
I
I
P
V
LAP
V
LG
HL
IML
K
F
P
W
QS
L
FW
T
M
A
I
M
G
I
A
V
L
M
L
S
L
F
IL
K
ET
R
P
A
A
P
AA
SD
K
SR
E
N
----
SE
S
L
L
N
R
F
FLSRV
V
I
TT
L
SV
S
V
I
LT
F
V
NT
SP
V
L
L
M
E
IM
G
F
ER
GE
Y
AT
I
M
A
L
TA
G
V
S
M
T
V
S
F-
-
-
--
--
STP
F
AL
GIF
K
P
--
----
-
-
R
T
L
M
I
T
S
Q
VLF
L
A-
--
--
-----
A
G
I
T
L
T
V
S
PSHAVSL
F
G
I
TLIC
A
G
FSVGFGV
AM
-----
S
QA
L
GP
F
SL
R
AG
V
AS
S
T
L
G
I
AQ
VC
G
S
S
L
WIW
L
AA
V
V
G-ISA
W
N
M
L
I
G
I
LI
A
C
S
I
V
S
L
L
LI
MFVA
fig|155864.8.peg.4614
Escherichia coli O157:H7 EDL933 (11-376/391)
L
V
L
L
Y
P
A
G
I
DMYL
VG
LP
R
I
A
A
D
L
NA
SE
AQ
LH
I
AF
S
VY
L
A
G
M
A
A
A
M
L
FA
G
K
V
A
D
RS
GRK
-
PV
A
I
P
G
AA
L
F
I
IT
SV
F
C
S
LAE
T
S
TL
F
L
A
G
RF
L
QGL
G
A
GCCY
VV
AF
A
I
L
RD
T
LD
DRRR
AK
V
L
S
L
L
N
G
I
T
C
I
I
P
V
LAP
V
LG
HL
IML
K
F
P
W
QS
L
FW
T
M
A
I
M
G
I
A
V
L
M
L
S
L
F
IL
K
ET
R
P
A
A
P
AA
SD
K
SR
E
N
----
SE
S
L
L
N
R
F
FLSRV
V
I
TT
L
SV
S
V
I
LT
F
V
NT
SP
V
L
L
M
E
IM
G
F
ER
GE
Y
AT
I
M
A
L
TA
G
V
S
M
T
V
S
F-
-
-
--
--
STP
F
AL
GIF
K
P
--
----
-
-
R
T
L
M
I
T
S
Q
VLF
L
A-
--
--
-----
A
G
I
T
L
T
V
S
PSHAVSL
F
G
I
TLIC
A
G
FSVGFGV
AM
-----
S
QA
L
GP
F
SL
R
AG
V
AS
S
T
L
G
I
AQ
VC
G
S
S
L
WIW
L
AA
V
V
G-ISA
W
N
M
L
I
G
I
LI
A
C
S
I
V
S
L
L
LI
MFVA
fig|444454.5.peg.3739
Escherichia coli O157:H7 str. EC4024 (11-376/391)
L
V
L
L
Y
P
A
G
I
DMYL
VG
LP
R
I
A
A
D
L
NA
SE
AQ
LH
I
AF
S
VY
L
A
G
M
A
A
A
M
L
FA
G
K
V
A
D
RS
GRK
-
PV
A
I
P
G
AA
L
F
I
IT
SV
F
C
S
LAE
T
S
TL
F
L
A
G
RF
L
QGL
G
A
GCCY
VV
AF
A
I
L
RD
T
LD
DRRR
AK
V
L
S
L
L
N
G
I
T
C
I
I
P
V
LAP
V
LG
HL
IML
K
F
P
W
QS
L
FW
T
M
A
I
M
G
I
A
V
L
M
L
S
L
F
IL
K
ET
R
P
A
A
P
AA
SD
K
SR
E
N
----
SE
S
L
L
N
R
F
FLSRV
V
I
TT
L
SV
S
V
I
LT
F
V
NT
SP
V
L
L
M
E
IM
G
F
ER
GE
Y
AT
I
M
A
L
TA
G
V
S
M
T
V
S
F-
-
-
--
--
STP
F
AL
GIF
K
P
--
----
-
-
R
T
L
M
I
T
S
Q
VLF
L
A-
--
--
-----
A
G
I
T
L
T
V
S
PSHAVSL
F
G
I
TLIC
A
G
FSVGFGV
AM
-----
S
QA
L
GP
F
SL
R
AG
V
AS
S
T
L
G
I
AQ
VC
G
S
S
L
WIW
L
AA
V
V
G-ISA
W
N
M
L
I
G
I
LI
A
C
S
I
V
S
L
L
LI
MFVA
fig|444449.5.peg.3193
Escherichia coli O157:H7 str. EC4042 (11-376/391)
L
V
L
L
Y
P
A
G
I
DMYL
VG
LP
R
I
A
A
D
L
NA
SE
AQ
LH
I
AF
S
VY
L
A
G
M
A
A
A
M
L
FA
G
K
V
A
D
RS
GRK
-
PV
A
I
P
G
AA
L
F
I
IT
SV
F
C
S
LAE
T
S
TL
F
L
A
G
RF
L
QGL
G
A
GCCY
VV
AF
A
I
L
RD
T
LD
DRRR
AK
V
L
S
L
L
N
G
I
T
C
I
I
P
V
LAP
V
LG
HL
IML
K
F
P
W
QS
L
FW
T
M
A
I
M
G
I
A
V
L
M
L
S
L
F
IL
K
ET
R
P
A
A
P
AA
SD
K
SR
E
N
----
SE
S
L
L
N
R
F
FLSRV
V
I
TT
L
SV
S
V
I
LT
F
V
NT
SP
V
L
L
M
E
IM
G
F
ER
GE
Y
AT
I
M
A
L
TA
G
V
S
M
T
V
S
F-
-
-
--
--
STP
F
AL
GIF
K
P
--
----
-
-
R
T
L
M
I
T
S
Q
VLF
L
A-
--
--
-----
A
G
I
T
L
T
V
S
PSHAVSL
F
G
I
TLIC
A
G
FSVGFGV
AM
-----
S
QA
L
GP
F
SL
R
AG
V
AS
S
T
L
G
I
AQ
VC
G
S
S
L
WIW
L
AA
V
V
G-ISA
W
N
M
L
I
G
I
LI
A
C
S
I
V
S
L
L
LI
MFVA
fig|444448.5.peg.1949
Escherichia coli O157:H7 str. EC4045 (11-376/391)
L
V
L
L
Y
P
A
G
I
DMYL
VG
LP
R
I
A
A
D
L
NA
SE
AQ
LH
I
AF
S
VY
L
A
G
M
A
A
A
M
L
FA
G
K
V
A
D
RS
GRK
-
PV
A
I
P
G
AA
L
F
I
IT
SV
F
C
S
LAE
T
S
TL
F
L
A
G
RF
L
QGL
G
A
GCCY
VV
AF
A
I
L
RD
T
LD
DRRR
AK
V
L
S
L
L
N
G
I
T
C
I
I
P
V
LAP
V
LG
HL
IML
K
F
P
W
QS
L
FW
T
M
A
I
M
G
I
A
V
L
M
L
S
L
F
IL
K
ET
R
P
A
A
P
AA
SD
K
SR
E
N
----
SE
S
L
L
N
R
F
FLSRV
V
I
TT
L
SV
S
V
I
LT
F
V
NT
SP
V
L
L
M
E
IM
G
F
ER
GE
Y
AT
I
M
A
L
TA
G
V
S
M
T
V
S
F-
-
-
--
--
STP
F
AL
GIF
K
P
--
----
-
-
R
T
L
M
I
T
S
Q
VLF
L
A-
--
--
-----
A
G
I
T
L
T
V
S
PSHAVSL
F
G
I
TLIC
A
G
FSVGFGV
AM
-----
S
QA
L
GP
F
SL
R
AG
V
AS
S
T
L
G
I
AQ
VC
G
S
S
L
WIW
L
AA
V
V
G-ISA
W
N
M
L
I
G
I
LI
A
C
S
I
V
S
L
L
LI
MFVA
fig|444453.5.peg.1479
Escherichia coli O157:H7 str. EC4076 (11-376/391)
L
V
L
L
Y
P
A
G
I
DMYL
VG
LP
R
I
A
A
D
L
NA
SE
AQ
LH
I
AF
S
VY
L
A
G
M
A
A
A
M
L
FA
G
K
V
A
D
RS
GRK
-
PV
A
I
P
G
AA
L
F
I
IT
SV
F
C
S
LAE
T
S
TL
F
L
A
G
RF
L
QGL
G
A
GCCY
VV
AF
A
I
L
RD
T
LD
DRRR
AK
V
L
S
L
L
N
G
I
T
C
I
I
P
V
LAP
V
LG
HL
IML
K
F
P
W
QS
L
FW
T
M
A
I
M
G
I
A
V
L
M
L
S
L
F
IL
K
ET
R
P
A
A
P
AA
SD
K
SR
E
N
----
SE
S
L
L
N
R
F
FLSRV
V
I
TT
L
SV
S
V
I
LT
F
V
NT
SP
V
L
L
M
E
IM
G
F
ER
GE
Y
AT
I
M
A
L
TA
G
V
S
M
T
V
S
F-
-
-
--
--
STP
F
AL
GIF
K
P
--
----
-
-
R
T
L
M
I
T
S
Q
VLF
L
A-
--
--
-----
A
G
I
T
L
T
V
S
PSHAVSL
F
G
I
TLIC
A
G
FSVGFGV
AM
-----
S
QA
L
GP
F
SL
R
AG
V
AS
S
T
L
G
I
AQ
VC
G
S
S
L
WIW
L
AA
V
V
G-ISA
W
N
M
L
I
G
I
LI
A
C
S
I
V
S
L
L
LI
MFVA
fig|444452.5.peg.1619
Escherichia coli O157:H7 str. EC4113 (11-376/391)
L
V
L
L
Y
P
A
G
I
DMYL
VG
LP
R
I
A
A
D
L
NA
SE
AQ
LH
I
AF
S
VY
L
A
G
M
A
A
A
M
L
FA
G
K
V
A
D
RS
GRK
-
PV
A
I
P
G
AA
L
F
I
IT
SV
F
C
S
LAE
T
S
TL
F
L
A
G
RF
L
QGL
G
A
GCCY
VV
AF
A
I
L
RD
T
LD
DRRR
AK
V
L
S
L
L
N
G
I
T
C
I
I
P
V
LAP
V
LG
HL
IML
K
F
P
W
QS
L
FW
T
M
A
I
M
G
I
A
V
L
M
L
S
L
F
IL
K
ET
R
P
A
A
P
AA
SD
K
SR
E
N
----
SE
S
L
L
N
R
F
FLSRV
V
I
TT
L
SV
S
V
I
LT
F
V
NT
SP
V
L
L
M
E
IM
G
F
ER
GE
Y
AT
I
M
A
L
TA
G
V
S
M
T
V
S
F-
-
-
--
--
STP
F
AL
GIF
K
P
--
----
-
-
R
T
L
M
I
T
S
Q
VLF
L
A-
--
--
-----
A
G
I
T
L
T
V
S
PSHAVSL
F
G
I
TLIC
A
G
FSVGFGV
AM
-----
S
QA
L
GP
F
SL
R
AG
V
AS
S
T
L
G
I
AQ
VC
G
S
S
L
WIW
L
AA
V
V
G-ISA
W
N
M
L
I
G
I
LI
A
C
S
I
V
S
L
L
LI
MFVA
fig|444450.8.peg.5031
Escherichia coli O157:H7 str. EC4115 (11-376/391)
L
V
L
L
Y
P
A
G
I
DMYL
VG
LP
R
I
A
A
D
L
NA
SE
AQ
LH
I
AF
S
VY
L
A
G
M
A
A
A
M
L
FA
G
K
V
A
D
RS
GRK
-
PV
A
I
P
G
AA
L
F
I
IT
SV
F
C
S
LAE
T
S
TL
F
L
A
G
RF
L
QGL
G
A
GCCY
VV
AF
A
I
L
RD
T
LD
DRRR
AK
V
L
S
L
L
N
G
I
T
C
I
I
P
V
LAP
V
LG
HL
IML
K
F
P
W
QS
L
FW
T
M
A
I
M
G
I
A
V
L
M
L
S
L
F
IL
K
ET
R
P
A
A
P
AA
SD
K
SR
E
N
----
SE
S
L
L
N
R
F
FLSRV
V
I
TT
L
SV
S
V
I
LT
F
V
NT
SP
V
L
L
M
E
IM
G
F
ER
GE
Y
AT
I
M
A
L
TA
G
V
S
M
T
V
S
F-
-
-
--
--
STP
F
AL
GIF
K
P
--
----
-
-
R
T
L
M
I
T
S
Q
VLF
L
A-
--
--
-----
A
G
I
T
L
T
V
S
PSHAVSL
F
G
I
TLIC
A
G
FSVGFGV
AM
-----
S
QA
L
GP
F
SL
R
AG
V
AS
S
T
L
G
I
AQ
VC
G
S
S
L
WIW
L
AA
V
V
G-ISA
W
N
M
L
I
G
I
LI
A
C
S
I
V
S
L
L
LI
MFVA
fig|444451.5.peg.35
Escherichia coli O157:H7 str. EC4196 (11-376/391)
L
V
L
L
Y
P
A
G
I
DMYL
VG
LP
R
I
A
A
D
L
NA
SE
AQ
LH
I
AF
S
VY
L
A
G
M
A
A
A
M
L
FA
G
K
V
A
D
RS
GRK
-
PV
A
I
P
G
AA
L
F
I
IT
SV
F
C
S
LAE
T
S
TL
F
L
A
G
RF
L
QGL
G
A
GCCY
VV
AF
A
I
L
RD
T
LD
DRRR
AK
V
L
S
L
L
N
G
I
T
C
I
I
P
V
LAP
V
LG
HL
IML
K
F
P
W
QS
L
FW
T
M
A
I
M
G
I
A
V
L
M
L
S
L
F
IL
K
ET
R
P
A
A
P
AA
SD
K
SR
E
N
----
SE
S
L
L
N
R
F
FLSRV
V
I
TT
L
SV
S
V
I
LT
F
V
NT
SP
V
L
L
M
E
IM
G
F
ER
GE
Y
AT
I
M
A
L
TA
G
V
S
M
T
V
S
F-
-
-
--
--
STP
F
AL
GIF
K
P
--
----
-
-
R
T
L
M
I
T
S
Q
VLF
L
A-
--
--
-----
A
G
I
T
L
T
V
S
PSHAVSL
F
G
I
TLIC
A
G
FSVGFGV
AM
-----
S
QA
L
GP
F
SL
R
AG
V
AS
S
T
L
G
I
AQ
VC
G
S
S
L
WIW
L
AA
V
V
G-ISA
W
N
M
L
I
G
I
LI
A
C
S
I
V
S
L
L
LI
MFVA
fig|444447.5.peg.2112
Escherichia coli O157:H7 str. EC4206 (11-376/391)
L
V
L
L
Y
P
A
G
I
DMYL
VG
LP
R
I
A
A
D
L
NA
SE
AQ
LH
I
AF
S
VY
L
A
G
M
A
A
A
M
L
FA
G
K
V
A
D
RS
GRK
-
PV
A
I
P
G
AA
L
F
I
IT
SV
F
C
S
LAE
T
S
TL
F
L
A
G
RF
L
QGL
G
A
GCCY
VV
AF
A
I
L
RD
T
LD
DRRR
AK
V
L
S
L
L
N
G
I
T
C
I
I
P
V
LAP
V
LG
HL
IML
K
F
P
W
QS
L
FW
T
M
A
I
M
G
I
A
V
L
M
L
S
L
F
IL
K
ET
R
P
A
A
P
AA
SD
K
SR
E
N
----
SE
S
L
L
N
R
F
FLSRV
V
I
TT
L
SV
S
V
I
LT
F
V
NT
SP
V
L
L
M
E
IM
G
F
ER
GE
Y
AT
I
M
A
L
TA
G
V
S
M
T
V
S
F-
-
-
--
--
STP
F
AL
GIF
K
P
--
----
-
-
R
T
L
M
I
T
S
Q
VLF
L
A-
--
--
-----
A
G
I
T
L
T
V
S
PSHAVSL
F
G
I
TLIC
A
G
FSVGFGV
AM
-----
S
QA
L
GP
F
SL
R
AG
V
AS
S
T
L
G
I
AQ
VC
G
S
S
L
WIW
L
AA
V
V
G-ISA
W
N
M
L
I
G
I
LI
A
C
S
I
V
S
L
L
LI
MFVA
fig|478004.5.peg.506
Escherichia coli O157:H7 str. EC4401 (11-376/391)
L
V
L
L
Y
P
A
G
I
DMYL
VG
LP
R
I
A
A
D
L
NA
SE
AQ
LH
I
AF
S
VY
L
A
G
M
A
A
A
M
L
FA
G
K
V
A
D
RS
GRK
-
PV
A
I
P
G
AA
L
F
I
IT
SV
F
C
S
LAE
T
S
TL
F
L
A
G
RF
L
QGL
G
A
GCCY
VV
AF
A
I
L
RD
T
LD
DRRR
AK
V
L
S
L
L
N
G
I
T
C
I
I
P
V
LAP
V
LG
HL
IML
K
F
P
W
QS
L
FW
T
M
A
I
M
G
I
A
V
L
M
L
S
L
F
IL
K
ET
R
P
A
A
P
AA
SD
K
SR
E
N
----
SE
S
L
L
N
R
F
FLSRV
V
I
TT
L
SV
S
V
I
LT
F
V
NT
SP
V
L
L
M
E
IM
G
F
ER
GE
Y
AT
I
M
A
L
TA
G
V
S
M
T
V
S
F-
-
-
--
--
STP
F
AL
GIF
K
P
--
----
-
-
R
T
L
M
I
T
S
Q
VLF
L
A-
--
--
-----
A
G
I
T
L
T
V
S
PSHAVSL
F
G
I
TLIC
A
G
FSVGFGV
AM
-----
S
QA
L
GP
F
SL
R
AG
V
AS
S
T
L
G
I
AQ
VC
G
S
S
L
WIW
L
AA
V
V
G-ISA
W
N
M
L
I
G
I
LI
A
C
S
I
V
S
L
L
LI
MFVA
fig|478005.5.peg.441
Escherichia coli O157:H7 str. EC4486 (11-376/391)
L
V
L
L
Y
P
A
G
I
DMYL
VG
LP
R
I
A
A
D
L
NA
SE
AQ
LH
I
AF
S
VY
L
A
G
M
A
A
A
M
L
FA
G
K
V
A
D
RS
GRK
-
PV
A
I
P
G
AA
L
F
I
IT
SV
F
C
S
LAE
T
S
TL
F
L
A
G
RF
L
QGL
G
A
GCCY
VV
AF
A
I
L
RD
T
LD
DRRR
AK
V
L
S
L
L
N
G
I
T
C
I
I
P
V
LAP
V
LG
HL
IML
K
F
P
W
QS
L
FW
T
M
A
I
M
G
I
A
V
L
M
L
S
L
F
IL
K
ET
R
P
A
A
P
AA
SD
K
SR
E
N
----
SE
S
L
L
N
R
F
FLSRV
V
I
TT
L
SV
S
V
I
LT
F
V
NT
SP
V
L
L
M
E
IM
G
F
ER
GE
Y
AT
I
M
A
L
TA
G
V
S
M
T
V
S
F-
-
-
--
--
STP
F
AL
GIF
K
P
--
----
-
-
R
T
L
M
I
T
S
Q
VLF
L
A-
--
--
-----
A
G
I
T
L
T
V
S
PSHAVSL
F
G
I
TLIC
A
G
FSVGFGV
AM
-----
S
QA
L
GP
F
SL
R
AG
V
AS
S
T
L
G
I
AQ
VC
G
S
S
L
WIW
L
AA
V
V
G-ISA
W
N
M
L
I
G
I
LI
A
C
S
I
V
S
L
L
LI
MFVA
fig|478006.5.peg.490
Escherichia coli O157:H7 str. EC4501 (11-376/391)
L
V
L
L
Y
P
A
G
I
DMYL
VG
LP
R
I
A
A
D
L
NA
SE
AQ
LH
I
AF
S
VY
L
A
G
M
A
A
A
M
L
FA
G
K
V
A
D
RS
GRK
-
PV
A
I
P
G
AA
L
F
I
IT
SV
F
C
S
LAE
T
S
TL
F
L
A
G
RF
L
QGL
G
A
GCCY
VV
AF
A
I
L
RD
T
LD
DRRR
AK
V
L
S
L
L
N
G
I
T
C
I
I
P
V
LAP
V
LG
HL
IML
K
F
P
W
QS
L
FW
T
M
A
I
M
G
I
A
V
L
M
L
S
L
F
IL
K
ET
R
P
A
A
P
AA
SD
K
SR
E
N
----
SE
S
L
L
N
R
F
FLSRV
V
I
TT
L
SV
S
V
I
LT
F
V
NT
SP
V
L
L
M
E
IM
G
F
ER
GE
Y
AT
I
M
A
L
TA
G
V
S
M
T
V
S
F-
-
-
--
--
STP
F
AL
GIF
K
P
--
----
-
-
R
T
L
M
I
T
S
Q
VLF
L
A-
--
--
-----
A
G
I
T
L
T
V
S
PSHAVSL
F
G
I
TLIC
A
G
FSVGFGV
AM
-----
S
QA
L
GP
F
SL
R
AG
V
AS
S
T
L
G
I
AQ
VC
G
S
S
L
WIW
L
AA
V
V
G-ISA
W
N
M
L
I
G
I
LI
A
C
S
I
V
S
L
L
LI
MFVA
fig|478007.5.peg.1549
Escherichia coli O157:H7 str. EC508 (11-376/391)
L
V
L
L
Y
P
A
G
I
DMYL
VG
LP
R
I
A
A
D
L
NA
SE
AQ
LH
I
AF
S
VY
L
A
G
M
A
A
A
M
L
FA
G
K
V
A
D
RS
GRK
-
PV
A
I
P
G
AA
L
F
I
IT
SV
F
C
S
LAE
T
S
TL
F
L
A
G
RF
L
QGL
G
A
GCCY
VV
AF
A
I
L
RD
T
LD
DRRR
AK
V
L
S
L
L
N
G
I
T
C
I
I
P
V
LAP
V
LG
HL
IML
K
F
P
W
QS
L
FW
T
M
A
I
M
G
I
A
V
L
M
L
S
L
F
IL
K
ET
R
P
A
A
P
AA
SD
K
SR
E
N
----
SE
S
L
L
N
R
F
FLSRV
V
I
TT
L
SV
S
V
I
LT
F
V
NT
SP
V
L
L
M
E
IM
G
F
ER
GE
Y
AT
I
M
A
L
TA
G
V
S
M
T
V
S
F-
-
-
--
--
STP
F
AL
GIF
K
P
--
----
-
-
R
T
L
M
I
T
S
Q
VLF
L
A-
--
--
-----
A
G
I
T
L
T
V
S
PSHAVSL
F
G
I
TLIC
A
G
FSVGFGV
AM
-----
S
QA
L
GP
F
SL
R
AG
V
AS
S
T
L
G
I
AQ
VC
G
S
S
L
WIW
L
AA
V
V
G-ISA
W
N
M
L
I
G
I
LI
A
C
S
I
V
S
L
L
LI
MFVA
fig|478008.5.peg.1832
Escherichia coli O157:H7 str. EC869 (11-376/391)
L
V
L
L
Y
P
A
G
I
DMYL
VG
LP
R
I
A
A
D
L
NA
SE
AQ
LH
I
AF
S
VY
L
A
G
M
A
A
A
M
L
FA
G
K
V
A
D
RS
GRK
-
PV
A
I
P
G
AA
L
F
I
IT
SV
F
C
S
LAE
T
S
TL
F
L
A
G
RF
L
QGL
G
A
GCCY
VV
AF
A
I
L
RD
T
LD
DRRR
AK
V
L
S
L
L
N
G
I
T
C
I
I
P
V
LAP
V
LG
HL
IML
K
F
P
W
QS
L
FW
T
M
A
I
M
G
I
A
V
L
M
L
S
L
F
IL
K
ET
R
P
A
A
P
AA
SD
K
SR
E
N
----
SE
S
L
L
N
R
F
FLSRV
V
I
TT
L
SV
S
V
I
LT
F
V
NT
SP
V
L
L
M
E
IM
G
F
ER
GE
Y
AT
I
M
A
L
TA
G
V
S
M
T
V
S
F-
-
-
--
--
STP
F
AL
GIF
K
P
--
----
-
-
R
T
L
M
I
T
S
Q
VLF
L
A-
--
--
-----
A
G
I
T
L
T
V
S
PSHAVSL
F
G
I
TLIC
A
G
FSVGFGV
AM
-----
S
QA
L
GP
F
SL
R
AG
V
AS
S
T
L
G
I
AQ
VC
G
S
S
L
WIW
L
AA
V
V
G-ISA
W
N
M
L
I
G
I
LI
A
C
S
I
V
S
L
L
LI
MFVA
fig|637388.3.peg.2969
Escherichia coli O157:H7 str. FRIK2000 (11-376/391)
L
V
L
L
Y
P
A
G
I
DMYL
VG
LP
R
I
A
A
D
L
NA
SE
AQ
LH
I
AF
S
VY
L
A
G
M
A
A
A
M
L
FA
G
K
V
A
D
RS
GRK
-
PV
A
I
P
G
AA
L
F
I
IT
SV
F
C
S
LAE
T
S
TL
F
L
A
G
RF
L
QGL
G
A
GCCY
VV
AF
A
I
L
RD
T
LD
DRRR
AK
V
L
S
L
L
N
G
I
T
C
I
I
P
V
LAP
V
LG
HL
IML
K
F
P
W
QS
L
FW
T
M
A
I
M
G
I
A
V
L
M
L
S
L
F
IL
K
ET
R
P
A
A
P
AA
SD
K
SR
E
N
----
SE
S
L
L
N
R
F
FLSRV
V
I
TT
L
SV
S
V
I
LT
F
V
NT
SP
V
L
L
M
E
IM
G
F
ER
GE
Y
AT
I
M
A
L
TA
G
V
S
M
T
V
S
F-
-
-
--
--
STP
F
AL
GIF
K
P
--
----
-
-
R
T
L
M
I
T
S
Q
VLF
L
A-
--
--
-----
A
G
I
T
L
T
V
S
PSHAVSL
F
G
I
TLIC
A
G
FSVGFGV
AM
-----
S
QA
L
GP
F
SL
R
AG
V
AS
S
T
L
G
I
AQ
VC
G
S
S
L
WIW
L
AA
V
V
G-ISA
W
N
M
L
I
G
I
LI
A
C
S
I
V
S
L
L
LI
MFVA
fig|570506.3.peg.4761
Escherichia coli O157:H7 str. FRIK966 (11-376/391)
L
V
L
L
Y
P
A
G
I
DMYL
VG
LP
R
I
A
A
D
L
NA
SE
AQ
LH
I
AF
S
VY
L
A
G
M
A
A
A
M
L
FA
G
K
V
A
D
RS
GRK
-
PV
A
I
P
G
AA
L
F
I
IT
SV
F
C
S
LAE
T
S
TL
F
L
A
G
RF
L
QGL
G
A
GCCY
VV
AF
A
I
L
RD
T
LD
DRRR
AK
V
L
S
L
L
N
G
I
T
C
I
I
P
V
LAP
V
LG
HL
IML
K
F
P
W
QS
L
FW
T
M
A
I
M
G
I
A
V
L
M
L
S
L
F
IL
K
ET
R
P
A
A
P
AA
SD
K
SR
E
N
----
SE
S
L
L
N
R
F
FLSRV
V
I
TT
L
SV
S
V
I
LT
F
V
NT
SP
V
L
L
M
E
IM
G
F
ER
GE
Y
AT
I
M
A
L
TA
G
V
S
M
T
V
S
F-
-
-
--
--
STP
F
AL
GIF
K
P
--
----
-
-
R
T
L
M
I
T
S
Q
VLF
L
A-
--
--
-----
A
G
I
T
L
T
V
S
PSHAVSL
F
G
I
TLIC
A
G
FSVGFGV
AM
-----
S
QA
L
GP
F
SL
R
AG
V
AS
S
T
L
G
I
AQ
VC
G
S
S
L
WIW
L
AA
V
V
G-ISA
W
N
M
L
I
G
I
LI
A
C
S
I
V
S
L
L
LI
MFVA
fig|386585.9.peg.4856
Escherichia coli O157:H7 str. Sakai (11-376/391)
L
V
L
L
Y
P
A
G
I
DMYL
VG
LP
R
I
A
A
D
L
NA
SE
AQ
LH
I
AF
S
VY
L
A
G
M
A
A
A
M
L
FA
G
K
V
A
D
RS
GRK
-
PV
A
I
P
G
AA
L
F
I
IT
SV
F
C
S
LAE
T
S
TL
F
L
A
G
RF
L
QGL
G
A
GCCY
VV
AF
A
I
L
RD
T
LD
DRRR
AK
V
L
S
L
L
N
G
I
T
C
I
I
P
V
LAP
V
LG
HL
IML
K
F
P
W
QS
L
FW
T
M
A
I
M
G
I
A
V
L
M
L
S
L
F
IL
K
ET
R
P
A
A
P
AA
SD
K
SR
E
N
----
SE
S
L
L
N
R
F
FLSRV
V
I
TT
L
SV
S
V
I
LT
F
V
NT
SP
V
L
L
M
E
IM
G
F
ER
GE
Y
AT
I
M
A
L
TA
G
V
S
M
T
V
S
F-
-
-
--
--
STP
F
AL
GIF
K
P
--
----
-
-
R
T
L
M
I
T
S
Q
VLF
L
A-
--
--
-----
A
G
I
T
L
T
V
S
PSHAVSL
F
G
I
TLIC
A
G
FSVGFGV
AM
-----
S
QA
L
GP
F
SL
R
AG
V
AS
S
T
L
G
I
AQ
VC
G
S
S
L
WIW
L
AA
V
V
G-ISA
W
N
M
L
I
G
I
LI
A
C
S
I
V
S
L
L
LI
MFVA
fig|544404.4.peg.4841
Escherichia coli O157:H7 str. TW14359 (11-376/391)
L
V
L
L
Y
P
A
G
I
DMYL
VG
LP
R
I
A
A
D
L
NA
SE
AQ
LH
I
AF
S
VY
L
A
G
M
A
A
A
M
L
FA
G
K
V
A
D
RS
GRK
-
PV
A
I
P
G
AA
L
F
I
IT
SV
F
C
S
LAE
T
S
TL
F
L
A
G
RF
L
QGL
G
A
GCCY
VV
AF
A
I
L
RD
T
LD
DRRR
AK
V
L
S
L
L
N
G
I
T
C
I
I
P
V
LAP
V
LG
HL
IML
K
F
P
W
QS
L
FW
T
M
A
I
M
G
I
A
V
L
M
L
S
L
F
IL
K
ET
R
P
A
A
P
AA
SD
K
SR
E
N
----
SE
S
L
L
N
R
F
FLSRV
V
I
TT
L
SV
S
V
I
LT
F
V
NT
SP
V
L
L
M
E
IM
G
F
ER
GE
Y
AT
I
M
A
L
TA
G
V
S
M
T
V
S
F-
-
-
--
--
STP
F
AL
GIF
K
P
--
----
-
-
R
T
L
M
I
T
S
Q
VLF
L
A-
--
--
-----
A
G
I
T
L
T
V
S
PSHAVSL
F
G
I
TLIC
A
G
FSVGFGV
AM
-----
S
QA
L
GP
F
SL
R
AG
V
AS
S
T
L
G
I
AQ
VC
G
S
S
L
WIW
L
AA
V
V
G-ISA
W
N
M
L
I
G
I
LI
A
C
S
I
V
S
L
L
LI
MFVA
fig|502346.5.peg.1966
Escherichia coli O157:H7 str. TW14588 (11-376/391)
L
V
L
L
Y
P
A
G
I
DMYL
VG
LP
R
I
A
A
D
L
NA
SE
AQ
LH
I
AF
S
VY
L
A
G
M
A
A
A
M
L
FA
G
K
V
A
D
RS
GRK
-
PV
A
I
P
G
AA
L
F
I
IT
SV
F
C
S
LAE
T
S
TL
F
L
A
G
RF
L
QGL
G
A
GCCY
VV
AF
A
I
L
RD
T
LD
DRRR
AK
V
L
S
L
L
N
G
I
T
C
I
I
P
V
LAP
V
LG
HL
IML
K
F
P
W
QS
L
FW
T
M
A
I
M
G
I
A
V
L
M
L
S
L
F
IL
K
ET
R
P
A
A
P
AA
SD
K
SR
E
N
----
SE
S
L
L
N
R
F
FLSRV
V
I
TT
L
SV
S
V
I
LT
F
V
NT
SP
V
L
L
M
E
IM
G
F
ER
GE
Y
AT
I
M
A
L
TA
G
V
S
M
T
V
S
F-
-
-
--
--
STP
F
AL
GIF
K
P
--
----
-
-
R
T
L
M
I
T
S
Q
VLF
L
A-
--
--
-----
A
G
I
T
L
T
V
S
PSHAVSL
F
G
I
TLIC
A
G
FSVGFGV
AM
-----
S
QA
L
GP
F
SL
R
AG
V
AS
S
T
L
G
I
AQ
VC
G
S
S
L
WIW
L
AA
V
V
G-ISA
W
N
M
L
I
G
I
LI
A
C
S
I
V
S
L
L
LI
MFVA
Consen1
Primary consensus
MTTRQHSSfaivfILglLa
lgpl
tDmYLPAlp
isaql
pa
tq
tLs
l
Gfa
gQLlyGPlsD
GRK
-
Pvvl
gllvFa
sv
ca
ni
Llv
RF
qgla
aaasVv
al
rD
Yp
sr
fa
vM
v
glaP
laPilGgwvlv
fsW
iFw
la
ia
vl
l
if
li
eTlp
n
rq
l
T
----
l
rhkr
Li
f
Ag
Fafl
spFvl
e
g
sP
f
vfgLn
-
v
l
ia
i
sr
Rri
Al
rggl
l
a
l
Vl
A
l
walv
-----
gf
s
vg
--------
cV
s
-------
Am
-----
a
l
fph
aGtAsaL
gt
fg
g
i
L
la
w
ms
si
-
c
t
sil
lyasRPKKR
Consen2
Secondary consensus
lswal
ag
s
imfm
i
l
fa
mqedf
tt
vs
s
t
i
lg
a
i
ma
r
l
f
stt
i
a
ml
ta
a
ha
g
cgga
si
t
q
q
ms
l
tis
ms
v
sy
vs
ld
l
a
mf
a
la
a
cl
fk
t
ka
e
sg
h
ignf
v
q
rt
a
a
s
s
i
gs
iy
k
h
a
-
yia
s
i
q
vm
f
gy
--
m
qs
--
i
p
w
i
i
ps
--
alfft
av
a
islveilipft
iypivvs
g
---
r
as
nm
lv
-
-
g
l
ii
at
l
i
a
m
mfva
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character