fig|1040638.4.peg.3263
Escherichia coli O104:H4 str. LB226692
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
D
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFR
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|6666666.5357.peg.530
Escherichia coli TY-2482
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
D
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFR
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|585055.6.peg.2469
Escherichia coli 55989
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFR
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|585055.8.peg.2475
Escherichia coli 55989
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFR
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|562.375.peg.3166
Escherichia coli EC4100B
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFR
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|573235.3.peg.3165
Escherichia coli O26:H11 str. 11368
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFR
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|656419.3.peg.2940
Escherichia coli M718
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|749537.3.peg.2469
Escherichia coli MS 115-1
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFR
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|585396.4.peg.2998
Escherichia coli O111:H- str. 11128
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFR
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
S
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|550676.3.peg.2480
Escherichia coli B185
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|216592.1.peg.2974
Escherichia coli 042 (17-545/545)
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|216592.3.peg.2522
Escherichia coli 042
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|656379.3.peg.2717
Escherichia coli FVEC1302
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|656380.3.peg.2276
Escherichia coli FVEC1412
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|679205.4.peg.4644
Escherichia coli MS 124-1
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|749549.3.peg.1846
Escherichia coli MS 198-1
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|749531.3.peg.1961
Escherichia coli MS 69-1
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|749533.3.peg.326
Escherichia coli MS 84-1
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|585056.7.peg.2699
Escherichia coli UMN026
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|749527.3.peg.175
Escherichia coli MS 21-1
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
R
V
L
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
FHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|562.371.peg.5042
Escherichia coli 1044A
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IDV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|562.373.peg.3931
Escherichia coli 1125A
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IDV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|562.372.peg.5587
Escherichia coli 1212A
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IDV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|562.374.peg.3331
Escherichia coli 536A
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IDV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|83334.1.peg.3066
Escherichia coli O157:H7
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IDV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|444454.5.peg.1996
Escherichia coli O157:H7 str. EC4024
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IDV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|444449.5.peg.1457
Escherichia coli O157:H7 str. EC4042
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IDV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|444448.5.peg.219
Escherichia coli O157:H7 str. EC4045
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IDV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|444453.5.peg.1565
Escherichia coli O157:H7 str. EC4076
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IDV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|444452.5.peg.2584
Escherichia coli O157:H7 str. EC4113
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IDV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|444450.8.peg.3309
Escherichia coli O157:H7 str. EC4115
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IDV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|444451.5.peg.817
Escherichia coli O157:H7 str. EC4196
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IDV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|444447.5.peg.353
Escherichia coli O157:H7 str. EC4206
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IDV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|478004.5.peg.5657
Escherichia coli O157:H7 str. EC4401
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IDV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|478005.5.peg.1845
Escherichia coli O157:H7 str. EC4486
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IDV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|478006.5.peg.4209
Escherichia coli O157:H7 str. EC4501
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IDV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|478007.5.peg.4967
Escherichia coli O157:H7 str. EC508
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IDV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|478008.5.peg.4112
Escherichia coli O157:H7 str. EC869
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IDV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|637388.3.peg.401
Escherichia coli O157:H7 str. FRIK2000
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IDV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|570506.3.peg.4931
Escherichia coli O157:H7 str. FRIK966
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IDV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|386585.9.peg.3204
Escherichia coli O157:H7 str. Sakai
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IDV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|544404.4.peg.3112
Escherichia coli O157:H7 str. TW14359
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IDV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|502346.5.peg.4311
Escherichia coli O157:H7 str. TW14588
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IDV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|701177.3.peg.2747
Escherichia coli O55:H7 str. CB9615
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IDV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|340186.3.peg.1288
Escherichia coli E110019
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|340186.5.peg.1336
Escherichia coli E110019
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|331111.12.peg.2765
Escherichia coli E24377A
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|331111.3.peg.221
Escherichia coli E24377A
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|656408.3.peg.2431
Escherichia coli H591
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|679206.4.peg.2407
Escherichia coli MS 119-7
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|749545.3.peg.4091
Escherichia coli MS 182-1
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|656443.3.peg.2890
Escherichia coli TA271
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|481805.3.peg.1572
Escherichia coli ATCC 8739 (17-545/545)
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VI
IL
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|155864.1.peg.3071
Escherichia coli O157:H7 EDL933
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LXI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IDV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|155864.8.peg.2963
Escherichia coli O157:H7 EDL933
MTQ
T
L
LA
I
E
D
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LXI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IDV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|358709.5.peg.629
Escherichia coli 101-1
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VI
IL
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|670888.3.peg.4098
Escherichia coli 1827-70
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VI
IL
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|344610.3.peg.1743
Escherichia coli 53638
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VI
IL
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|344610.7.peg.4249
Escherichia coli 53638
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VI
IL
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|481805.6.peg.1564
Escherichia coli ATCC 8739
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VI
IL
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|595496.3.peg.2150
Escherichia coli BW2952
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VI
IL
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|536056.3.peg.1552
Escherichia coli DH1
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VI
IL
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|316401.4.peg.2651
Escherichia coli ETEC H10407
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VI
IL
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|656414.3.peg.2553
Escherichia coli H736
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VI
IL
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|83333.1.peg.2155
Escherichia coli K12
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VI
IL
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|749540.3.peg.834
Escherichia coli MS 146-1
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VI
IL
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|749547.3.peg.2617
Escherichia coli MS 187-1
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VI
IL
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|749548.3.peg.2187
Escherichia coli MS 196-1
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VI
IL
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|316407.3.peg.2114
Escherichia coli W3110
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VI
IL
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|316385.5.peg.2303
Escherichia coli str. K-12 substr. DH10B
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VI
IL
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|316385.7.peg.2358
Escherichia coli str. K-12 substr. DH10B
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VI
IL
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|511145.12.peg.2268
Escherichia coli str. K-12 substr. MG1655
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VI
IL
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|511145.6.peg.2252
Escherichia coli str. K-12 substr. MG1655
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VI
IL
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|753642.3.peg.2908
Escherichia coli NC101
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
KNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|685038.3.peg.2242
Escherichia coli O83:H1 str. NRG 857C
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
KNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|562.376.peg.4104
Escherichia coli WV_060327
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
KNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|405955.9.peg.1958
Escherichia coli APEC O1 (17-545/545)
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
I
RG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|656393.3.peg.3214
Escherichia coli H299
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
I
V
F
D
G
K
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|439855.10.peg.2497
Escherichia coli SMS-3-5
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
H-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|431946.3.peg.2156
Escherichia coli SE15
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
L
H
I
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
KNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
H-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|656444.3.peg.3174
Escherichia coli TA280
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
NPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|405955.13.peg.2402
Escherichia coli APEC O1
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
I
RG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|714962.3.peg.2462
Escherichia coli IHE3034
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
I
RG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|585035.6.peg.2309
Escherichia coli S88
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
I
RG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|869729.3.peg.1248
Escherichia coli UM146
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
I
RG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|364106.7.peg.2488
Escherichia coli UTI89
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
I
RG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|364106.8.peg.2489
Escherichia coli UTI89
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
I
RG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|656437.3.peg.2453
Escherichia coli TA143
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
H
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|656417.3.peg.2856
Escherichia coli M605
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
H-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|525281.3.peg.3987
Escherichia coli 83972
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
KNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
H-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|655817.3.peg.2630
Escherichia coli ABU 83972
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
KNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
H-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|199310.1.peg.2646
Escherichia coli CFT073
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
KNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
H-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|199310.4.peg.2559
Escherichia coli CFT073
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
KNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
H-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|749546.3.peg.2963
Escherichia coli MS 185-1
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
KNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
H-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|749528.3.peg.2580
Escherichia coli MS 45-1
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
KNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
H-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|656440.3.peg.2169
Escherichia coli TA206
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
KNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
ID
S
Q-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|344601.3.peg.1417
Escherichia coli B171
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHV
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|344601.5.peg.1493
Escherichia coli B171
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHV
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|340184.3.peg.425
Escherichia coli B7A
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHV
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|340184.6.peg.443
Escherichia coli B7A
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHV
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|340185.3.peg.615
Escherichia coli E22
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHV
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|340185.4.peg.657
Escherichia coli E22
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHV
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|585034.4.peg.2232
Escherichia coli IAI1
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHV
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|585034.5.peg.2229
Escherichia coli IAI1
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHV
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|595495.4.peg.253
Escherichia coli KO11
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHV
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|679207.4.peg.4060
Escherichia coli MS 107-1
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHV
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|679204.3.peg.216
Escherichia coli MS 145-7
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHV
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|749544.3.peg.2557
Escherichia coli MS 175-1
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHV
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|585395.4.peg.2781
Escherichia coli O103:H2 str. 12009
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHV
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|566546.3.peg.1448
Escherichia coli W
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHV
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|566546.4.peg.2362
Escherichia coli W
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHV
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|749532.3.peg.3465
Escherichia coli MS 78-1
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
FNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
SLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|331112.3.peg.2176
Escherichia coli HS
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
H
LL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VI
IL
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|331112.6.peg.2275
Escherichia coli HS
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
H
LL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VI
IL
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|749538.3.peg.3252
Escherichia coli MS 116-1
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
H
LL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VI
IL
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|362663.8.peg.2240
Escherichia coli 536
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PK
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|362663.9.peg.2244
Escherichia coli 536
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PK
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|340197.3.peg.242
Escherichia coli F11
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PK
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|340197.5.peg.252
Escherichia coli F11
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PK
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|749550.3.peg.1755
Escherichia coli MS 200-1
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PK
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|550677.3.peg.1729
Escherichia coli B354
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
R
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
VQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|585397.7.peg.2635
Escherichia coli ED1a
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
V
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
KNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
I
V
F
D
G
K
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|585397.9.peg.2632
Escherichia coli ED1a
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
V
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
KNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
I
V
F
D
G
K
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|216593.1.peg.2565
Escherichia coli E2348/69 (17-545/545)
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
KNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
ID
S
Q-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IAR
V
L
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|670897.3.peg.3158
Escherichia coli 2362-75
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
KNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
ID
S
Q-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IAR
V
L
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|574521.7.peg.2380
Escherichia coli O127:H6 str. E2348/69
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
A
A
GETLALVGESGSGKSVTALS
I
L
RLL
P
C
PPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
KNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
ID
S
Q-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IAR
V
L
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|409438.11.peg.2605
Escherichia coli SE11
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHV
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
R
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|550672.3.peg.1899
Escherichia coli B088
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHV
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
APV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|413997.3.peg.2204
Escherichia coli B str. REL606
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
VI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLA
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VI
IL
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|511693.5.peg.2215
Escherichia coli BL21
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
VI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLA
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VI
IL
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|469008.4.peg.1519
Escherichia coli BL21(DE3)
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
VI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNC
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNYAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
IIF
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLA
A
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VI
IL
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
T
PQ
QE
YTRQLLALS
fig|585057.4.peg.2416
Escherichia coli IAI39
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNS
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
V
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|585057.6.peg.2418
Escherichia coli IAI39
MTQ
T
L
LA
I
E
N
LS
VG
F
RHQ
Q
TVRT
V
V
N
D
VS
LQI
E
A
GETLALVGESGSGKSVTALS
I
L
RLL
PSPPV
E
YLS
G
DI--
-
----RFH
GE
S
L
LHA
S
D
Q
T
-
-
-
LR
G
VRG
NK
IAMIFQEPM
V
SLNP
LH
T
L
E
K
QL
Y
E
V
L
----
S
LH
RGM
RRE
A
A
RG
E
I
LNS
LD
R
VGI
RQ
A
AKR
L
TD
YPHQLSGG
E
RQRVMIAMAL
LT
RP
E
L
LIADEPTTALDV
SV
QAQIL
Q
L
L
R
E
LQ
G
E
L
-
N
MG
M
L
FITH
N
L
SI
V
R
K
L
A
H
RV
A
VM
Q
NG
RC
VE
QNNAAT
LF
AS
P
T
HPYTQ
K
LL
NS
EP
---
-
-
S
G
DPV
P
-------
L
PE
PA
S
T
------
--------
L
L
D
V
EQ
L
QVA
FPIR
K
G
I
L
K
R
IVDHNVV
V
KNI
SF
T
LR
A
GETLGLVGESGSGKSTTG
L
ALLRL
IN
S
Q-
G
S
I
V
F
D
GQ
PLQN
L
NR
R
QL
LP
I
--------
R
HR
IQ
V
V
FQD
--
P
NS
SL
N
PR
L
N
V
LQI
I
E
E
GL
RVH
--
Q
P
TLS
V
AQ
R
EQQ
V
IAV
M
H
E
VGL
-
D
PET
RH
RYP
A
EFSGGQRQRI
A
IARAL
I
L
K
P
SL
IILDEPTS
S
LD
K
TVQ
AQI
L
T
LL
KS
LQ
Q
K
H
Q
LAYLFISHDL
H
VV
RALC
H
Q
VIV
L
R
Q
G
E
V
VE
Q
GP
C
A
R
VFA
A
PQ
QE
YTRQLLALS
fig|753642.3.peg.834
Escherichia coli NC101 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQE
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
VDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LS
S
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
R
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|656440.3.peg.686
Escherichia coli TA206 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQE
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
VDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LS
S
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
R
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|216592.1.peg.3356
Escherichia coli 042 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVKQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LS
S
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|216592.3.peg.947
Escherichia coli 042 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVKQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LS
S
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|585057.4.peg.854
Escherichia coli IAI39 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LS
S
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|585057.6.peg.850
Escherichia coli IAI39 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LS
S
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|550677.3.peg.2099
Escherichia coli B354 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
QMLLRRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
P
H
HPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LS
S
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|656379.3.peg.1669
Escherichia coli FVEC1302 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
C
GETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
QMLLRRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEH
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LS
S
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
P
K
HPYTR
K
LLA
fig|656380.3.peg.1496
Escherichia coli FVEC1412 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
C
GETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
QMLLRRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEH
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LS
S
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
P
K
HPYTR
K
LLA
fig|749549.3.peg.121
Escherichia coli MS 198-1 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
C
GETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
QMLLRRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEH
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LS
S
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
P
K
HPYTR
K
LLA
fig|585056.7.peg.1209
Escherichia coli UMN026 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
C
GETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
QMLLRRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEH
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LS
S
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
P
K
HPYTR
K
LLA
fig|749531.3.peg.1720
Escherichia coli MS 69-1 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
QMLLRRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LS
S
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|656444.3.peg.1383
Escherichia coli TA280 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
QMLLRRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LS
S
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|749527.3.peg.4405
Escherichia coli MS 21-1 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
N
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
TA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|481805.3.peg.3023
Escherichia coli ATCC 8739 (18-571/629)
V
LA
V
E
N
L
K
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|331112.3.peg.821
Escherichia coli HS (18-571/629)
V
LA
V
E
N
L
K
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|656437.3.peg.911
Escherichia coli TA143 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
QMLLRRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LS
S
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|216593.1.peg.1427
Escherichia coli E2348/69 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQE
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LS
S
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|670888.3.peg.1391
Escherichia coli 1827-70 (12-565/623)
V
LA
V
E
N
L
K
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|481805.6.peg.3011
Escherichia coli ATCC 8739 (12-565/623)
V
LA
V
E
N
L
K
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|331112.6.peg.856
Escherichia coli HS (12-565/623)
V
LA
V
E
N
L
K
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|656419.3.peg.1115
Escherichia coli M718 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QV
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|656393.3.peg.1585
Escherichia coli H299 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQE
Q
HKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
QMLLRRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MI
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LS
S
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
P
K
HPYTR
K
LLA
fig|670897.3.peg.4800
Escherichia coli 2362-75 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQE
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LS
S
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|574521.7.peg.805
Escherichia coli O127:H6 str. E2348/69 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQE
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LS
S
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|550676.3.peg.291
Escherichia coli B185 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
FVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
S
V
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QV
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|562.371.peg.2219
Escherichia coli 1044A (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
VA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|562.373.peg.1202
Escherichia coli 1125A (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
VA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|562.372.peg.1067
Escherichia coli 1212A (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
VA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|562.374.peg.2601
Escherichia coli 536A (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
VA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|444449.5.peg.4334
Escherichia coli O157:H7 str. EC4042 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
VA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|444451.5.peg.3880
Escherichia coli O157:H7 str. EC4196 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
VA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|478005.5.peg.1452
Escherichia coli O157:H7 str. EC4486 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
VA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|478006.5.peg.3724
Escherichia coli O157:H7 str. EC4501 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
VA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|478008.5.peg.2301
Escherichia coli O157:H7 str. EC869 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
VA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|637388.3.peg.2601
Escherichia coli O157:H7 str. FRIK2000 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
VA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|570506.3.peg.4428
Escherichia coli O157:H7 str. FRIK966 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
VA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|386585.9.peg.1023
Escherichia coli O157:H7 str. Sakai (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
VA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|544404.4.peg.933
Escherichia coli O157:H7 str. TW14359 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
VA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|502346.5.peg.282
Escherichia coli O157:H7 str. TW14588 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
VA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|444454.5.peg.5400
Escherichia coli O157:H7 str. EC4024 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
VA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|444448.5.peg.3610
Escherichia coli O157:H7 str. EC4045 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
VA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|444453.5.peg.952
Escherichia coli O157:H7 str. EC4076 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
VA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|444452.5.peg.2996
Escherichia coli O157:H7 str. EC4113 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
VA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|444450.8.peg.1067
Escherichia coli O157:H7 str. EC4115 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
VA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|444447.5.peg.3804
Escherichia coli O157:H7 str. EC4206 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
VA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|478004.5.peg.3329
Escherichia coli O157:H7 str. EC4401 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
VA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|478007.5.peg.2603
Escherichia coli O157:H7 str. EC508 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
VA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|656417.3.peg.1018
Escherichia coli M605 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQE
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
ESSIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
L
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|431946.3.peg.789
Escherichia coli SE15 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQE
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
ESSIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
L
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|749537.3.peg.201
Escherichia coli MS 115-1 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
A
I
IFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
C
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|714962.3.peg.836
Escherichia coli IHE3034 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQE
Q
HKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VSR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
L
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|585035.6.peg.848
Escherichia coli S88 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQE
Q
HKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VSR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
L
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|869729.3.peg.2883
Escherichia coli UM146 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQE
Q
HKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VSR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
L
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|364106.7.peg.917
Escherichia coli UTI89 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQE
Q
HKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VSR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
L
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|364106.8.peg.916
Escherichia coli UTI89 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQE
Q
HKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VSR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
L
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|83334.1.peg.974
Escherichia coli O157:H7 (1-554/612)
M
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
VA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|562.376.peg.4775
Escherichia coli WV_060327 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQE
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
L
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|331111.12.peg.1190
Escherichia coli E24377A (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|679205.4.peg.2102
Escherichia coli MS 124-1 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|749545.3.peg.2465
Escherichia coli MS 182-1 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|749532.3.peg.822
Escherichia coli MS 78-1 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|749533.3.peg.4843
Escherichia coli MS 84-1 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|409438.11.peg.1014
Escherichia coli SE11 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|331111.3.peg.3398
Escherichia coli E24377A (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|656408.3.peg.837
Escherichia coli H591 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|656443.3.peg.1108
Escherichia coli TA271 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|679206.4.peg.3732
Escherichia coli MS 119-7 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
V
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|1040638.4.peg.4672
Escherichia coli O104:H4 str. LB226692 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|585055.6.peg.885
Escherichia coli 55989 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|585055.8.peg.889
Escherichia coli 55989 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|550672.3.peg.1101
Escherichia coli B088 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|344601.5.peg.2610
Escherichia coli B171 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|340184.6.peg.1295
Escherichia coli B7A (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|340186.5.peg.2642
Escherichia coli E110019 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|340185.4.peg.2978
Escherichia coli E22 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|562.375.peg.4424
Escherichia coli EC4100B (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|595495.4.peg.4031
Escherichia coli KO11 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|679207.4.peg.2119
Escherichia coli MS 107-1 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|679204.3.peg.2557
Escherichia coli MS 145-7 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|585396.4.peg.933
Escherichia coli O111:H- str. 11128 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|573235.3.peg.974
Escherichia coli O26:H11 str. 11368 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|405955.13.peg.788
Escherichia coli APEC O1 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQE
Q
HKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VSR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
W
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
L
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
A
M
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|585034.4.peg.855
Escherichia coli IAI1 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFP
F
IS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|585034.5.peg.851
Escherichia coli IAI1 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFP
F
IS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|6666666.5357.peg.3778
Escherichia coli TY-2482 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|405955.9.peg.662
Escherichia coli APEC O1 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQE
Q
HKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VSR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
W
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
L
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
A
M
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|344601.3.peg.2506
Escherichia coli B171 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|340184.3.peg.1231
Escherichia coli B7A (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|340186.3.peg.2556
Escherichia coli E110019 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|340185.3.peg.2827
Escherichia coli E22 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|585395.4.peg.920
Escherichia coli O103:H2 str. 12009 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|566546.4.peg.879
Escherichia coli W (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|439855.10.peg.1010
Escherichia coli SMS-3-5 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
C
P
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LS
S
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|362663.8.peg.849
Escherichia coli 536 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQE
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
L
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|362663.9.peg.849
Escherichia coli 536 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQE
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
L
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|585397.7.peg.802
Escherichia coli ED1a (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQE
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
L
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|585397.9.peg.802
Escherichia coli ED1a (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQE
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
L
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|340197.3.peg.3859
Escherichia coli F11 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQE
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
L
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|340197.5.peg.4033
Escherichia coli F11 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQE
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
L
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|685038.3.peg.754
Escherichia coli O83:H1 str. NRG 857C (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQE
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
L
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|749550.3.peg.3739
Escherichia coli MS 200-1 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQE
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
L
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|358709.5.peg.3110
Escherichia coli 101-1 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
N
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|413997.3.peg.839
Escherichia coli B str. REL606 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
N
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|511693.5.peg.867
Escherichia coli BL21 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
N
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|469008.4.peg.2894
Escherichia coli BL21(DE3) (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
N
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|595496.3.peg.753
Escherichia coli BW2952 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
N
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|536056.3.peg.2969
Escherichia coli DH1 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
N
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|656414.3.peg.1029
Escherichia coli H736 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
N
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|749538.3.peg.701
Escherichia coli MS 116-1 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
N
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|749540.3.peg.2767
Escherichia coli MS 146-1 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
N
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|749544.3.peg.2716
Escherichia coli MS 175-1 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
N
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|749547.3.peg.1621
Escherichia coli MS 187-1 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
N
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|749548.3.peg.3169
Escherichia coli MS 196-1 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
N
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|316385.5.peg.894
Escherichia coli str. K-12 substr. DH10B (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
N
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|316385.7.peg.906
Escherichia coli str. K-12 substr. DH10B (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
N
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|511145.12.peg.856
Escherichia coli str. K-12 substr. MG1655 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
N
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|511145.6.peg.849
Escherichia coli str. K-12 substr. MG1655 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
N
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|155864.1.peg.901
Escherichia coli O157:H7 EDL933 (1-554/612)
M
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMR
X
RVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
VA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|83333.1.peg.815
Escherichia coli K12 (1-554/612)
M
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
N
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|155864.8.peg.929
Escherichia coli O157:H7 EDL933 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMR
X
RVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
VA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|316407.3.peg.796
Escherichia coli W3110 (1-554/612)
M
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
N
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|701177.3.peg.1039
Escherichia coli O55:H7 str. CB9615 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
D
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPT
I
ALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
VA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|525281.3.peg.2124
Escherichia coli 83972 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQE
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
A
V
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
C
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|655817.3.peg.916
Escherichia coli ABU 83972 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQE
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
A
V
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
C
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|199310.4.peg.868
Escherichia coli CFT073 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQE
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
A
V
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
C
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|749546.3.peg.4932
Escherichia coli MS 185-1 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQE
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
A
V
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
C
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|749528.3.peg.4569
Escherichia coli MS 45-1 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQE
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
A
V
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
C
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|199310.1.peg.887
Escherichia coli CFT073 (18-571/629)
V
LA
V
E
N
L
N
IA
F
MQE
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
A
V
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGSVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
C
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKE
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|344610.3.peg.3266
Escherichia coli 53638 (18-571/629)
V
LA
V
E
N
L
K
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQE
S
M
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|344610.7.peg.854
Escherichia coli 53638 (12-565/623)
V
LA
V
E
N
L
K
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLRRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQE
S
M
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
EPPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|316401.4.peg.1037
Escherichia coli ETEC H10407 (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESG
F
GKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
N
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
VTREVHA
V
EKV
SF
D
L
W
PGETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|566546.3.peg.4352
Escherichia coli W (12-565/623)
V
LA
V
E
N
L
N
IA
F
MQD
Q
QKIA
AV
R
N
L
SFSL
Q
RGETLA
I
VGESGSGKSVTAL
A
LMRLL
-----
E
QAG
G
LVQC
D
KMLLQRR
S
R
E
V
IEL
S
E
Q
S
A
A
Q
M
R
H
VRG
AD
M
AMIFQEPM
T
SLNP
VF
TV
G
EQ
I
A
E
S
I
----
R
LH
QNA
S
REEA
MV
EA
KRM
LD
Q
V
R
I
PE
A
QTI
L
SR
YPHQLSGGMRQRVMIAMAL
SC
RP
A
VLIADEPTTALDV
TI
QAQIL
Q
LI
K
V
LQ
K
E
M
-
S
MGVIFITH
D
M
GV
V
A
E
IADRV
L
VM
Y
Q
G
EA
VE
TGTVEQ
I
F
HA
PQHPYT
R
A
LL
AA
V
P
QLG
A
M
K
G
LDY
P
RRFPLIS
L
EH
PA
K
Q
APPIEQ
KTVVDGEP
V
L
R
V
RN
L
VTR
FP
L
R
S
G
L
L
N
R
ETREVHA
V
EKV
SF
D
L
W
P
R
ETL
S
LVGESGSGKSTTG
R
ALLRL
VE
S
QG
G
E
IIF
N
GQ
RIDT
LSP
G
K
L
QA
L
--------
R
RD
IQ
F
IFQD
--
P
YA
SLDPR
Q
T
I
GDS
I
I
E
PL
RVH
GL
LP
GKD
A
AA
R
---
V
AWL
L
E
RVGL
-
L
PE
H
AW
RYP
H
EFSGGQRQRI
C
IARAL
A
L
N
P
KV
II
A
DE
AV
S
A
LDV
SIR
G
QII
N
LL
LD
LQ
R
D
F
G
I
AYLFISHD
M
A
VV
ERIS
HRV
A
VM
Y
L
G
Q
I
VE
I
GP
R
R
A
VF
E
N
PQHPYTR
K
LLA
fig|585396.4.peg.4220
Escherichia coli O111:H- str. 11128 (1-489/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
K
M
LA
D
C
QNL
L
A
E
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
I
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEI
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YQ
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
V
N
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
E
NLT
Q
T
fig|573235.3.peg.4462
Escherichia coli O26:H11 str. 11368 (1-489/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
K
M
LA
D
C
QNL
L
A
E
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
I
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEI
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YQ
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
V
N
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
E
NLT
Q
T
fig|656417.3.peg.4091
Escherichia coli M605 (1-489/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
K
M
LA
D
C
QNL
L
A
E
L
GI
PL
D
PQE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
V
N
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
E
NLT
Q
T
fig|585397.7.peg.3914
Escherichia coli ED1a (1-489/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
K
M
LA
D
C
QNL
L
A
E
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VI
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
V
N
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
E
NLT
Q
T
fig|585397.9.peg.3911
Escherichia coli ED1a (1-489/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
K
M
LA
D
C
QNL
L
A
E
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VI
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
V
N
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
E
NLT
Q
T
fig|405955.13.peg.3671
Escherichia coli APEC O1 (1-483/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
K
M
LA
D
C
QNL
L
A
D
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
V
N
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
fig|405955.9.peg.3065
Escherichia coli APEC O1 (11-493/509)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
K
M
LA
D
C
QNL
L
A
D
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
V
N
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
fig|585035.6.peg.3571
Escherichia coli S88 (1-483/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
K
M
LA
D
C
QNL
L
A
D
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
V
N
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
fig|869729.3.peg.22
Escherichia coli UM146 (1-483/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
K
M
LA
D
C
QNL
L
A
D
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
V
N
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
fig|364106.7.peg.3644
Escherichia coli UTI89 (1-483/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
K
M
LA
D
C
QNL
L
A
D
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
V
N
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
fig|364106.8.peg.3645
Escherichia coli UTI89 (1-483/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
K
M
LA
D
C
QNL
L
A
D
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
V
N
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
fig|714962.3.peg.3709
Escherichia coli IHE3034 (1-483/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
K
M
LA
D
C
QNL
L
A
D
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
V
N
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
AM
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
fig|362663.8.peg.3374
Escherichia coli 536 (1-489/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
K
M
LA
D
C
QNL
L
A
E
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
V
N
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
E
NLT
Q
T
fig|362663.9.peg.3385
Escherichia coli 536 (1-489/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
K
M
LA
D
C
QNL
L
A
E
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
V
N
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
E
NLT
Q
T
fig|340197.3.peg.3956
Escherichia coli F11 (11-499/509)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
K
M
LA
D
C
QNL
L
A
E
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
V
N
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
E
NLT
Q
T
fig|340197.5.peg.4132
Escherichia coli F11 (1-489/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
K
M
LA
D
C
QNL
L
A
E
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
V
N
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
E
NLT
Q
T
fig|749550.3.peg.1314
Escherichia coli MS 200-1 (1-489/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
K
M
LA
D
C
QNL
L
A
E
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
V
N
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
E
NLT
Q
T
fig|753642.3.peg.4710
Escherichia coli NC101 (1-489/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
K
M
LA
D
C
QNL
L
A
E
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
V
N
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
E
NLT
Q
T
fig|685038.3.peg.3292
Escherichia coli O83:H1 str. NRG 857C (1-489/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
K
M
LA
D
C
QNL
L
A
E
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
V
N
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
E
NLT
Q
T
fig|431946.3.peg.3219
Escherichia coli SE15 (1-489/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
K
M
LA
D
C
QNL
L
A
E
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
V
N
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
E
NLT
Q
T
fig|656440.3.peg.3489
Escherichia coli TA206 (1-489/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
K
M
LA
D
C
QNL
L
A
E
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
V
N
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
E
NLT
Q
T
fig|562.376.peg.1643
Escherichia coli WV_060327 (1-489/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
K
M
LA
D
C
QNL
L
A
E
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
V
N
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
E
NLT
Q
T
fig|525281.3.peg.3776
Escherichia coli 83972 (1-489/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
E
M
LA
D
C
QNL
L
A
E
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
IN
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
E
NLT
Q
T
fig|655817.3.peg.3832
Escherichia coli ABU 83972 (1-489/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
E
M
LA
D
C
QNL
L
A
E
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
IN
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
E
NLT
Q
T
fig|749546.3.peg.1832
Escherichia coli MS 185-1 (1-489/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
E
M
LA
D
C
QNL
L
A
E
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
IN
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
E
NLT
Q
T
fig|749528.3.peg.4215
Escherichia coli MS 45-1 (1-489/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
E
M
LA
D
C
QNL
L
A
E
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
IN
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
E
NLT
Q
T
fig|749527.3.peg.2176
Escherichia coli MS 21-1 (1-489/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
K
M
LA
D
C
QNL
L
A
E
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
V
N
M
N
T
HHV
A
F
Q
YN
ASR
--
I
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
E
NLT
Q
T
fig|585057.4.peg.3879
Escherichia coli IAI39 (1-489/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
N
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
K
M
LA
D
C
QNL
L
A
E
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
V
N
M
N
T
HHV
A
F
Q
YN
ASR
--
I
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
E
NLT
Q
T
fig|585057.6.peg.3888
Escherichia coli IAI39 (1-489/499)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
N
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
K
M
LA
D
C
QNL
L
A
E
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
K
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
V
N
M
N
T
HHV
A
F
Q
YN
ASR
--
I
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
E
NLT
Q
T
fig|199310.1.peg.3925
Escherichia coli CFT073 (11-498/508)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
E
M
LA
D
C
QNL
L
A
E
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
-
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
IN
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
E
NLT
Q
T
fig|199310.4.peg.3781
Escherichia coli CFT073 (1-488/498)
MT
D
V
IL
D
V
S
H
IA
KT
F
GHV
Q
----
A
L
K
D
IT
L
SLR
K
G
RVHT
L
L
GE
N
G
A
GKS
----
T
LM
K
I
L
-----
-
--A
G
VYPP
T
QGTITLR
GE
T
I
TIN
N
P
Q
H
S
R
QL
-
-
---
-G
IA
I
IFQE
L
-
-
SL
S
N
NM
TV
A
E
NI
-
-
Y
ANN
EP
R
RF
GII
ND
K
E
M
LA
D
C
QNL
L
A
E
L
GI
PL
D
PLE
M
VG
---
N
M
S
M
A
H
RQ
L
V
E
IA
K
AL
SY
A
A
D
V
V
I
M
DEPT
S
S
L
SD
NE
A
E
I
LF
N
I
I
E
K
L
K
Q
R
-
-
G
CA
VI
Y
I
S
H
R
M
DE
I
M
R
I
S
D
D
I
S
V
I
R
D
G
EY
I
A
THEKKN
S
-
--
DIQH
L
IA
Q
M
V
GR
E
M
KNI
W
-
-
-
---
-
-------
P
AR
L
G
E
K
--PDEN
--------
-
-
-
-
--
-
---
--
V
P
A
K
L
E
V
K
NLSHPSL
F
KEV
SF
A
V
RPGE
V
LG
FF
G
L
V
G
A
G
R
S
DVM
K
AL
FG
L
V-
S
YH
G
T
V
LI
D
G
K
EVRI
A
N
P
-
Q
A
ID
H
GI
A
F
VT
E
N
R
KE
E
G
L
V
LMH
--
-
--
--
D
IN
M
N
T
HHV
A
F
Q
YN
ASR
--
M
G
LIN
H
RQ
E
EAK
T
LQS
I
A
R
M
NTK
V
S
S
V
HQ
AV
-
G
A
L
SGG
NQ
Q
K
I
V
LS
K
W
L
E
K
T
P
RI
L
L
LDEPT
R
G
V
DV
GAK
F
E
I
Y
N
V
I
RQ
L
A
A
A
-
G
T
A
I
I
L
V
S
SE
L
P
E
V
MALS
D
R
LV
VMR
N
-
K
T
I
A
D
I
Y
S
C
E
NLT
Q
T
fig|216592.1.peg.735
Escherichia coli 042 (20-493/911)
QH
Y
GKT
V
----
A
L
N
N
IT
L
D
I
P
A
RCM
V
G
L
I
G
PD
G
V
GKS
----
SL
L
S
L
I
-----
-
--S
G
ARVI
E
QGNVIVL
G
G
D
I
--R
D
P
K
H
R
R
D
V
-
-
--
C
PR
IA
W
M
P
Q
GLG
K
N
L
YH
TL
S
V
Y
E
N
V
D
F
F
A
----
R
L
F
GH-
D
K
A
E
R
EV
RI
NEL
L
T
S
T
G
L
AP
F
RDR
P
AG
---
K
LSGGM
K
Q
KL
G
L
C
C
AL
IH
D
P
E
L
LI
L
DEPTT
G
V
D
P
LS
R
AQ
FW
D
LI
D
S
I
R
Q
R
Q
S
N
M
S
V
L
VA
T
A
Y
M
EE
A
E
R
F-
D
W
L
V
A
M
N
A
G
EV
L
A
TGSAEE
-
-
--
-------
-
-
L
RQ
Q
T
QSA
T
-
-
-
---
-
-------
L
EE
A
F
I
N
LLPQAQ
RQAHQAVV
I
P
P
Y
QP
E
NAE
IA
I
E
A
R
D
L
T
M
RFGSFVA
V
DHV
N
F
R
I
PR
GE
I
F
G
F
L
G
S
N
G
C
GKSTT
M
K
M
L
T
G
L
LP
A
SE
G
E
A
WL
F
GQ
PV--
-D
P
K
D
I
--
-
------
DT
R
RR
V
G
Y
M
S
Q
A
FSL
YN
E
L
T
V
R
Q
N
L
ELH
A
-
-
--
--R
--
L
F
HIP
E
AE
I
PAR
V
AEM
S
E
R
F--K
L
N
D
V
ED
VL
P
E
S
L
PL
G
I
RQR
L
S
L
A
V
A
V
I
H
R
P
EM
L
ILDEPTS
G
V
D
P
VAR
DMFW
Q
L
M
VD
L
S
R
Q
-
DKVT
I
FIS
THF
M
NE
AERC
D
R
I
S
L
M
H
A
GK
V
L
A
S
G
T
P
Q
E
fig|216592.3.peg.3914
Escherichia coli 042 (20-493/911)
QH
Y
GKT
V
----
A
L
N
N
IT
L
D
I
P
A
RCM
V
G
L
I
G
PD
G
V
GKS
----
SL
L
S
L
I
-----
-
--S
G
ARVI
E
QGNVIVL
G
G
D
I
--R
D
P
K
H
R
R
D
V
-
-
--
C
PR
IA
W
M
P
Q
GLG
K
N
L
YH
TL
S
V
Y
E
N
V
D
F
F
A
----
R
L
F
GH-
D
K
A
E
R
EV
RI
NEL
L
T
S
T
G
L
AP
F
RDR
P
AG
---
K
LSGGM
K
Q
KL
G
L
C
C
AL
IH
D
P
E
L
LI
L
DEPTT
G
V
D
P
LS
R
AQ
FW
D
LI
D
S
I
R
Q
R
Q
S
N
M
S
V
L
VA
T
A
Y
M
EE
A
E
R
F-
D
W
L
V
A
M
N
A
G
EV
L
A
TGSAEE
-
-
--
-------
-
-
L
RQ
Q
T
QSA
T
-
-
-
---
-
-------
L
EE
A
F
I
N
LLPQAQ
RQAHQAVV
I
P
P
Y
QP
E
NAE
IA
I
E
A
R
D
L
T
M
RFGSFVA
V
DHV
N
F
R
I
PR
GE
I
F
G
F
L
G
S
N
G
C
GKSTT
M
K
M
L
T
G
L
LP
A
SE
G
E
A
WL
F
GQ
PV--
-D
P
K
D
I
--
-
------
DT
R
RR
V
G
Y
M
S
Q
A
FSL
YN
E
L
T
V
R
Q
N
L
ELH
A
-
-
--
--R
--
L
F
HIP
E
AE
I
PAR
V
AEM
S
E
R
F--K
L
N
D
V
ED
VL
P
E
S
L
PL
G
I
RQR
L
S
L
A
V
A
V
I
H
R
P
EM
L
ILDEPTS
G
V
D
P
VAR
DMFW
Q
L
M
VD
L
S
R
Q
-
DKVT
I
FIS
THF
M
NE
AERC
D
R
I
S
L
M
H
A
GK
V
L
A
S
G
T
P
Q
E
fig|749531.3.peg.1588
Escherichia coli MS 69-1 (20-493/911)
QH
Y
GKT
V
----
A
L
N
N
IT
L
D
I
P
A
RCM
V
G
L
I
G
PD
G
V
GKS
----
SL
L
S
L
I
-----
-
--S
G
ARVI
E
QGNVMVL
G
G
D
M
--R
D
P
K
H
R
R
D
V
-
-
--
C
PR
IA
W
M
P
Q
GLG
K
N
L
YH
TL
S
V
Y
E
N
V
D
F
F
A
----
R
L
F
GH-
D
K
A
E
R
EV
RI
NEL
L
T
S
T
G
L
AP
F
RDR
P
AG
---
K
LSGGM
K
Q
KL
G
L
C
C
AL
IH
D
P
E
L
LI
L
DEPTT
G
V
D
P
LS
R
AQ
FW
D
LI
D
S
I
R
Q
R
Q
S
N
M
S
V
L
VA
T
A
Y
M
EE
A
E
R
F-
D
W
L
V
A
M
N
A
G
EV
L
A
TGSAEE
-
-
--
-------
-
-
L
RQ
Q
T
QSA
T
-
-
-
---
-
-------
L
EE
A
F
I
N
LLPQAQ
RQAHQAVV
I
P
P
Y
QP
E
NAE
IA
I
E
A
R
D
L
T
M
RFGSFVA
V
DHV
N
F
R
I
PR
GE
I
F
G
F
L
G
S
N
G
C
GKSTT
M
K
M
L
T
G
L
LP
A
SE
G
E
A
WL
F
GQ
PV--
-D
P
K
D
I
--
-
------
DT
R
RR
V
G
Y
M
S
Q
A
FSL
YN
E
L
T
V
R
Q
N
L
ELH
A
-
-
--
--R
--
L
F
HIP
E
AE
I
PAR
V
AEM
S
E
R
F--K
L
N
D
V
ED
VL
P
E
S
L
PL
G
I
RQR
L
S
L
A
V
A
V
I
H
R
P
EM
L
ILDEPTS
G
V
D
P
VAR
DMFW
Q
L
M
VD
L
S
R
Q
-
DKVT
I
FIS
THF
M
NE
AERC
D
R
I
S
L
M
H
A
GK
V
L
A
S
G
T
P
Q
E
fig|656444.3.peg.4757
Escherichia coli TA280 (20-493/911)
QH
Y
GKT
V
----
A
L
N
N
IT
L
D
I
P
A
RCM
V
G
L
I
G
PD
G
V
GKS
----
SL
L
S
L
I
-----
-
--S
G
ARVI
E
QGNVMVL
G
G
D
M
--R
D
P
K
H
R
R
D
V
-
-
--
C
PR
IA
W
M
P
Q
GLG
K
N
L
YH
TL
S
V
Y
E
N
V
D
F
F
A
----
R
L
F
GH-
D
K
A
E
R
EV
RI
NEL
L
T
S
T
G
L
AP
F
RDR
P
AG
---
K
LSGGM
K
Q
KL
G
L
C
C
AL
IH
D
P
E
L
LI
L
DEPTT
G
V
D
P
LS
R
AQ
FW
D
LI
D
S
I
R
Q
R
Q
S
N
M
S
V
L
VA
T
A
Y
M
EE
A
E
R
F-
D
W
L
V
A
M
N
A
G
EV
L
A
TGSAEE
-
-
--
-------
-
-
L
RQ
Q
T
QSA
T
-
-
-
---
-
-------
L
EE
A
F
I
N
LLPQAQ
RQAHQAVV
I
P
P
Y
QP
E
NAE
IA
I
E
A
R
D
L
T
M
RFGSFVA
V
DHV
N
F
R
I
PR
GE
I
F
G
F
L
G
S
N
G
C
GKSTT
M
K
M
L
T
G
L
LP
A
SE
G
E
A
WL
F
GQ
PV--
-D
P
K
D
I
--
-
------
DT
R
RR
V
G
Y
M
S
Q
A
FSL
YN
E
L
T
V
R
Q
N
L
ELH
A
-
-
--
--R
--
L
F
HIP
E
AE
I
PAR
V
AEM
S
E
R
F--K
L
N
D
V
ED
VL
P
E
S
L
PL
G
I
RQR
L
S
L
A
V
A
V
I
H
R
P
EM
L
ILDEPTS
G
V
D
P
VAR
DMFW
Q
L
M
VD
L
S
R
Q
-
DKVT
I
FIS
THF
M
NE
AERC
D
R
I
S
L
M
H
A
GK
V
L
A
S
G
T
P
Q
E
fig|550677.3.peg.4035
Escherichia coli B354 (20-493/911)
QH
Y
GKT
V
----
A
L
N
N
IT
L
D
I
P
A
RCM
V
G
L
I
G
PD
G
V
GKS
----
SL
L
S
L
I
-----
-
--S
G
ARVI
E
QGNVIVL
G
G
D
M
--R
D
P
K
H
R
R
D
V
-
-
--
C
PR
IA
W
M
P
Q
GLG
K
N
L
YH
TL
S
V
Y
E
N
V
D
F
F
A
----
R
L
F
GH-
D
K
A
E
R
EV
RI
NEL
L
T
S
T
G
L
AP
F
RDR
P
AG
---
K
LSGGM
K
Q
KL
G
L
C
C
AL
IH
D
P
E
L
LI
L
DEPTT
G
V
D
P
LS
R
AQ
FW
D
LI
D
S
I
R
Q
R
Q
S
N
M
S
V
L
VA
T
A
Y
M
EE
A
E
R
F-
D
W
L
V
A
M
N
A
G
EV
L
A
TGSAEE
-
-
--
-------
-
-
L
RQ
Q
T
QSA
T
-
-
-
---
-
-------
L
EE
A
F
I
N
LLPQAQ
RQAHQAVV
I
P
P
Y
QP
E
NAE
IA
I
E
A
R
D
L
T
M
RFGSFVA
V
DHV
N
F
R
I
PR
GE
I
F
G
F
L
G
S
N
G
C
GKSTT
M
K
M
L
T
G
L
LP
A
SE
G
E
A
WL
F
GQ
PV--
-D
P
K
D
I
--
-
------
DT
R
RR
V
G
Y
M
S
Q
A
FSL
YN
E
L
T
V
R
Q
N
L
ELH
A
-
-
--
--R
--
L
F
HIP
E
AE
I
PAR
V
AEM
S
E
R
F--K
L
N
D
V
ED
VL
P
E
S
L
PL
G
I
RQR
L
S
L
A
V
A
V
I
H
R
P
EM
L
ILDEPTS
G
V
D
P
VAR
DMFW
Q
L
M
VD
L
S
R
Q
-
DKVT
I
FIS
THF
M
NE
AERC
D
R
I
S
L
M
H
A
GK
V
L
A
S
G
T
P
Q
E
fig|413997.3.peg.4323
Escherichia coli B str. REL606 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
Q
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|511693.5.peg.4345
Escherichia coli BL21 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
Q
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|469008.4.peg.3946
Escherichia coli BL21(DE3) (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
Q
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|536056.3.peg.3998
Escherichia coli DH1 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SSK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|358709.5.peg.2449
Escherichia coli 101-1 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|670888.3.peg.4495
Escherichia coli 1827-70 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|344610.3.peg.609
Escherichia coli 53638 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|344610.7.peg.1891
Escherichia coli 53638 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|481805.3.peg.4062
Escherichia coli ATCC 8739 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|481805.6.peg.4046
Escherichia coli ATCC 8739 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|340184.3.peg.2325
Escherichia coli B7A (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|340184.6.peg.2442
Escherichia coli B7A (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|595496.3.peg.4303
Escherichia coli BW2952 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|316401.4.peg.5197
Escherichia coli ETEC H10407 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|749540.3.peg.3129
Escherichia coli MS 146-1 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|749545.3.peg.1028
Escherichia coli MS 182-1 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|749547.3.peg.414
Escherichia coli MS 187-1 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|749548.3.peg.3793
Escherichia coli MS 196-1 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
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D
L
M
R
Q
L
R
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R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
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V
L
R
NG
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V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
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L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
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V
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A
G
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G
K
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R
SP
H
Q
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L
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R
KT
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I
I
AAA
--
-
--
--
S
V
R
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NI
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A
L
Q
AQ
R
GW
--
L
R
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R
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I
R
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L
G
IR
T
P
S
T
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PI
-
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NQ
Q
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L
LS
R
W
L
L
T
R
P
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L
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R
G
I
DV
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A
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R
L
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L
C
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L
L
V
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L
E
EL
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D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
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L
fig|749527.3.peg.1234
Escherichia coli MS 21-1 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
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RTE
T
A
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VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
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NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
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R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
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L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|478008.5.peg.257
Escherichia coli O157:H7 str. EC869 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
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RTE
T
A
E
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KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
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R
G
I
DV
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A
E
II
R
L
I
ET
L
C
A
D
-
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L
L
V
IS
SE
L
E
EL
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D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|637388.3.peg.2468
Escherichia coli O157:H7 str. FRIK2000 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
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RTE
T
A
E
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KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
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A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
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L
L
V
IS
SE
L
E
EL
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D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|570506.3.peg.1252
Escherichia coli O157:H7 str. FRIK966 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
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A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
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L
L
V
IS
SE
L
E
EL
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D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|701177.3.peg.5061
Escherichia coli O55:H7 str. CB9615 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
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A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
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L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|585035.6.peg.4715
Escherichia coli S88 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
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D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|656443.3.peg.5263
Escherichia coli TA271 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
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K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|316407.3.peg.4064
Escherichia coli W3110 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|316385.5.peg.4374
Escherichia coli str. K-12 substr. DH10B (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|316385.7.peg.4464
Escherichia coli str. K-12 substr. DH10B (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|511145.12.peg.4360
Escherichia coli str. K-12 substr. MG1655 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|511145.6.peg.4338
Escherichia coli str. K-12 substr. MG1655 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|562.371.peg.3752
Escherichia coli 1044A (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AR
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|562.372.peg.3305
Escherichia coli 1212A (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AR
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|562.374.peg.5708
Escherichia coli 536A (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AR
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|83334.1.peg.5185
Escherichia coli O157:H7 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AR
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|155864.1.peg.5168
Escherichia coli O157:H7 EDL933 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AR
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|155864.8.peg.5156
Escherichia coli O157:H7 EDL933 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AR
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|478006.5.peg.1037
Escherichia coli O157:H7 str. EC4501 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AR
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|386585.9.peg.5442
Escherichia coli O157:H7 str. Sakai (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AR
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|502346.5.peg.1426
Escherichia coli O157:H7 str. TW14588 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AR
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|550672.3.peg.4578
Escherichia coli B088 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GFL
RR
K
E
M
EK
R
A
TEL
M
T
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|679204.3.peg.13
Escherichia coli MS 145-7 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GFL
RR
K
E
M
EK
R
A
TEL
M
T
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|749532.3.peg.3741
Escherichia coli MS 78-1 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GFL
RR
K
E
M
EK
R
A
TEL
M
T
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|550676.3.peg.4505
Escherichia coli B185 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|656419.3.peg.5483
Escherichia coli M718 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
D
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETCE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|670897.3.peg.1603
Escherichia coli 2362-75 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GFL
RR
K
E
M
EK
R
A
TEL
M
T
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|656408.3.peg.4738
Escherichia coli H591 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GFL
RR
K
E
M
EK
R
A
TEL
M
T
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|679206.4.peg.1100
Escherichia coli MS 119-7 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GFL
RR
K
E
M
EK
R
A
TEL
M
T
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|679205.4.peg.1177
Escherichia coli MS 124-1 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GFL
RR
K
E
M
EK
R
A
TEL
M
T
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|749533.3.peg.3860
Escherichia coli MS 84-1 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GFL
RR
K
E
M
EK
R
A
TEL
M
T
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|656414.3.peg.4799
Escherichia coli H736 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
Q
L
fig|439855.10.peg.4812
Escherichia coli SMS-3-5 (5-487/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
T
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGM
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
fig|525281.3.peg.1636
Escherichia coli 83972 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
S
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|655817.3.peg.4986
Escherichia coli ABU 83972 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
S
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|199310.1.peg.5216
Escherichia coli CFT073 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
S
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|199310.4.peg.4989
Escherichia coli CFT073 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
S
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|749546.3.peg.2460
Escherichia coli MS 185-1 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
S
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|749528.3.peg.3440
Escherichia coli MS 45-1 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
S
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|331111.12.peg.4998
Escherichia coli E24377A (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|331111.3.peg.2391
Escherichia coli E24377A (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|562.375.peg.2841
Escherichia coli EC4100B (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|331112.3.peg.4195
Escherichia coli HS (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|331112.6.peg.4367
Escherichia coli HS (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|585057.4.peg.4840
Escherichia coli IAI39 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|585057.6.peg.4848
Escherichia coli IAI39 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|573235.3.peg.5576
Escherichia coli O26:H11 str. 11368 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|685038.3.peg.4388
Escherichia coli O83:H1 str. NRG 857C (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|344601.3.peg.900
Escherichia coli B171 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
FL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|344601.5.peg.952
Escherichia coli B171 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
FL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|340185.3.peg.1982
Escherichia coli E22 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
FL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|340185.4.peg.2097
Escherichia coli E22 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
FL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|595495.4.peg.4256
Escherichia coli KO11 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
FL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|585395.4.peg.5283
Escherichia coli O103:H2 str. 12009 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
FL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|566546.3.peg.3088
Escherichia coli W (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
FL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|566546.4.peg.4523
Escherichia coli W (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
FL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|749531.3.peg.3670
Escherichia coli MS 69-1 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
N
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
T
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
QQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
QRF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|362663.8.peg.4509
Escherichia coli 536 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
I
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
LQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|362663.9.peg.4525
Escherichia coli 536 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
I
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
LQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|340197.3.peg.911
Escherichia coli F11 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
I
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
LQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|340197.5.peg.962
Escherichia coli F11 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
I
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
LQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|656393.3.peg.459
Escherichia coli H299 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
I
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
LQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|749550.3.peg.3364
Escherichia coli MS 200-1 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
I
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
LQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|585397.7.peg.5053
Escherichia coli ED1a (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
N
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
LQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
T
E
I
P
L
A
E
L
fig|585397.9.peg.5054
Escherichia coli ED1a (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
N
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
LQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
T
E
I
P
L
A
E
L
fig|1040638.4.peg.926
Escherichia coli O104:H4 str. LB226692 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GFL
RR
K
E
M
EK
R
A
TEL
M
T
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
QQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|6666666.5357.peg.835
Escherichia coli TY-2482 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GFL
RR
K
E
M
EK
R
A
TEL
M
T
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
QQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|585055.6.peg.4808
Escherichia coli 55989 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GFL
RR
K
E
M
EK
R
A
TEL
M
T
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
QQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|585055.8.peg.4812
Escherichia coli 55989 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GFL
RR
K
E
M
EK
R
A
TEL
M
T
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
QQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|679207.4.peg.3502
Escherichia coli MS 107-1 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GFL
RR
K
E
M
EK
R
A
TEL
M
T
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
QQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|409438.11.peg.4716
Escherichia coli SE11 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GFL
RR
K
E
M
EK
R
A
TEL
M
T
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
QQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|656440.3.peg.4808
Escherichia coli TA206 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
S
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
LQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|656379.3.peg.606
Escherichia coli FVEC1302 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GFL
RR
K
E
M
EK
R
A
TEL
M
T
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
V
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
QQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|656380.3.peg.596
Escherichia coli FVEC1412 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GFL
RR
K
E
M
EK
R
A
TEL
M
T
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
V
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
QQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|749549.3.peg.3275
Escherichia coli MS 198-1 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GFL
RR
K
E
M
EK
R
A
TEL
M
T
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
V
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
QQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|585056.7.peg.4926
Escherichia coli UMN026 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GFL
RR
K
E
M
EK
R
A
TEL
M
T
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
V
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
QQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|749537.3.peg.442
Escherichia coli MS 115-1 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
T
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
QQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
QRF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|656437.3.peg.4747
Escherichia coli TA143 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
T
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
QQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|656444.3.peg.120
Escherichia coli TA280 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
T
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
QQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
QRF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|550677.3.peg.228
Escherichia coli B354 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
N
I
D
FSLR
C
GE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
T
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
AQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|585396.4.peg.5328
Escherichia coli O111:H- str. 11128 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
PQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
G
P
A
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|753642.3.peg.3813
Escherichia coli NC101 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHV
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
LQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|869729.3.peg.4593
Escherichia coli UM146 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHV
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
LQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|364106.7.peg.4708
Escherichia coli UTI89 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHV
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
LQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|364106.8.peg.4707
Escherichia coli UTI89 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHV
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
LQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|562.376.peg.537
Escherichia coli WV_060327 (5-489/500)
QH
Q
E
IL
R
T
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GLL
RR
K
E
M
EK
R
A
TEL
MA
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
A
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
QQTL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
S
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|585034.4.peg.4338
Escherichia coli IAI1 (5-489/500)
QH
Q
E
IL
R
S
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GFL
RR
K
E
M
EK
R
A
TEL
M
T
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
E
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
QQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
fig|585034.5.peg.4335
Escherichia coli IAI1 (5-489/500)
QH
Q
E
IL
R
S
E
G
LS
KF
F
PGV
K
----
A
L
D
NV
D
FSLRRGE
IM
AL
L
GE
N
G
A
GKS
----
T
L
I
KA
L
-----
-
--T
G
VYHA
D
RGTIWLE
G
Q
A
I
SPK
N
T
A
H
A
Q
QL
-
-
---
-G
I
GTVY
QE
V
-
-
N
L
L
P
NM
S
V
A
D
N
L
-
-
F
I
GREP
K
RF
GFL
RR
K
E
M
EK
R
A
TEL
M
T
S
Y
G
F
SL
D
VRE
P
LN
---
RF
S
VA
M
Q
Q
I
V
A
I
CR
A
I
DL
SA
K
VLI
L
DEPT
AS
LD
T
QE
VELLF
G
L
M
R
Q
L
R
D
R
-
-
G
VS
L
IF
V
TH
F
L
DQ
V
Y
QV
S
DR
I
T
V
L
R
NG
SF
V
G
CRETRE
L
-
--
PQ
IELV
K
M
M
L
GR
E
L
DTH
E
-
-
-
---
-
-------
L
QR
AG
R
T
LLSDKP
--------
-
-
-
-
--
-
---
--
V
A
A
-
-
-
F
K
NYGKKGT
I
APF
DL
E
V
RPGE
IV
GL
A
G
LL
GSG
RTE
T
A
E
VIFGI
KP
A
DS
G
T
ALI
K
G
K
QQNL
R
SP
H
Q
A
SV
L
GIGFCPED
R
KT
DG
I
I
AAA
--
-
--
--
S
V
R
E
NI
-IL
A
L
Q
AQ
R
GW
--
L
R
PIS
R
KE
Q
QEI
A
ERF
I
R
Q
L
G
IR
T
P
S
T
EQ
PI
-
E
FL
SGG
NQ
Q
KV
L
LS
R
W
L
L
T
R
P
QF
L
ILDEPT
R
G
I
DV
GAH
A
E
II
R
L
I
ET
L
C
A
D
-
GLA
L
L
V
IS
SE
L
E
EL
VGYA
D
RVI
I
MR
D
R
K
Q
V
A
E
I
P
L
A
E
L
Consen1
Primary consensus
mtq
iLa
E
Ls
F
q
av
nvsfslrrGEtlAlvGEsGsGKSvtalslmrlL
-----
e
G
d
ge
i
s
q
a
qlr
vrg
iamifQEpm
sLnP
tv
eql
e
i
----
lh
rReea
ea
ld
vgi
a
l
yphqlSggmrQrVmIamAl
rp
vLIaDEPTtaLDv
qaqil
Lir
Lq
e
-
mgviFiTH
l
V
kiadRv
Vm
nG
Ve
lf
Pqhpytq
lL
ep
a
-
g
p
-------
L
pa
t
--------
l
v
l
fpir
g
l
r
v
sf
lrpGEtlgLvGesGSGkstTg
allrl
s
G
iif
Gq
lsp
ql
l
--------
R
iq
ifqd
--
p
sldpR
ni
i
e
Rvh
--
lp
a
r
v
i
rvGl
-
Pet
ryp
efSGGqrQri
iaRaL
l
P
iIlDEpts
lDv
aqIi
Ll
Lq
d
glAyLfIShdl
vv
hrVivmr
gk
Ve
gP
a
vFa
PQhpYTRqLLALS
Consen2
Secondary consensus
qhd
r
n
k
vl
dldlqi
a
im
il
n
a
----
i
ka
psppv
-
-
s
n
a
-
-
m
-
---
mgtvy
v
-
n
l
sl
ni
-
lgrep
rf
s
kam
ri
ma
yrf
d
p
---
rf
vaeq
i
a
cr
i
sa
l
l
as
t
vellf
k
r
r
vs
l
v
m
sh
i
l
q
g
i
-
tielv
m
vl
-
m
-
-
rrfplis
ag
q
ktvvdgep
-
-
-
--
a
-
-
k
i
dl
vwa
ivs
a
ll
rte
a
vifgi
a
ali
k
rnr
ka
igigfcped
dg
vaaa
-
--
v
tv
a
q
gwglqr
r
q
a
l
ir
sh
pi
-
fl
nq
kv
ls
w
t
l
a
avr
i
k
ge
l
i
c
k
qi
l
v
sem
el
dq
aily
r
a
i
r
l
e
qe
k
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character