fig|1040638.4.peg.3157
Escherichia coli O104:H4 str. LB226692
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GQG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LE
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|585055.6.peg.2366
Escherichia coli 55989 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GQG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LE
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|585055.8.peg.2373
Escherichia coli 55989 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GQG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LE
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|656408.3.peg.2278
Escherichia coli H591 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GQG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LE
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KV
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|749545.3.peg.10
Escherichia coli MS 182-1 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GQG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LE
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KV
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|749532.3.peg.4103
Escherichia coli MS 78-1 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GQG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LE
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KV
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|550672.3.peg.1794
Escherichia coli B088 (369-1023/1023)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KV
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|331111.12.peg.2647
Escherichia coli E24377A (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|331111.3.peg.109
Escherichia coli E24377A (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|562.371.peg.4280
Escherichia coli 1044A (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
IS
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|562.372.peg.5780
Escherichia coli 1212A (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
IS
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|562.374.peg.1790
Escherichia coli 536A (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
IS
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|83334.1.peg.2887
Escherichia coli O157:H7 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
IS
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|155864.1.peg.2891
Escherichia coli O157:H7 EDL933 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
IS
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|155864.8.peg.2775
Escherichia coli O157:H7 EDL933 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
IS
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|478005.5.peg.3683
Escherichia coli O157:H7 str. EC4486 (369-1023/1023)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
IS
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|478006.5.peg.2302
Escherichia coli O157:H7 str. EC4501 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
IS
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|478008.5.peg.3901
Escherichia coli O157:H7 str. EC869 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
IS
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|637388.3.peg.2194
Escherichia coli O157:H7 str. FRIK2000 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
IS
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|570506.3.peg.3472
Escherichia coli O157:H7 str. FRIK966 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
IS
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|386585.9.peg.3015
Escherichia coli O157:H7 str. Sakai (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
IS
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|502346.5.peg.4502
Escherichia coli O157:H7 str. TW14588 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
IS
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|562.375.peg.2295
Escherichia coli EC4100B (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
E
L
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|656414.3.peg.2434
Escherichia coli H736 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
E
L
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|585034.4.peg.2126
Escherichia coli IAI1 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
E
L
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|585034.5.peg.2121
Escherichia coli IAI1 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
E
L
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|679207.4.peg.3868
Escherichia coli MS 107-1 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
E
L
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|679206.4.peg.1593
Escherichia coli MS 119-7 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
E
L
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|679204.3.peg.105
Escherichia coli MS 145-7 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
E
L
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|749544.3.peg.957
Escherichia coli MS 175-1 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
E
L
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|656443.3.peg.2773
Escherichia coli TA271 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
E
L
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|656444.3.peg.3048
Escherichia coli TA280 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|562.373.peg.4607
Escherichia coli 1125A (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
IS
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|444454.5.peg.1747
Escherichia coli O157:H7 str. EC4024 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
IS
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|444449.5.peg.1223
Escherichia coli O157:H7 str. EC4042 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
IS
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|444448.5.peg.5497
Escherichia coli O157:H7 str. EC4045 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
IS
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|444453.5.peg.3716
Escherichia coli O157:H7 str. EC4076 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
IS
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|444452.5.peg.3369
Escherichia coli O157:H7 str. EC4113 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
IS
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|444450.8.peg.3017
Escherichia coli O157:H7 str. EC4115 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
IS
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|444451.5.peg.3058
Escherichia coli O157:H7 str. EC4196 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
IS
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|444447.5.peg.118
Escherichia coli O157:H7 str. EC4206 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
IS
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|478004.5.peg.4589
Escherichia coli O157:H7 str. EC4401 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
IS
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|478007.5.peg.1817
Escherichia coli O157:H7 str. EC508 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
IS
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|544404.4.peg.2879
Escherichia coli O157:H7 str. TW14359 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
IS
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|362663.8.peg.2126
Escherichia coli 536 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|362663.9.peg.2131
Escherichia coli 536 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|656417.3.peg.2742
Escherichia coli M605 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|431946.3.peg.2048
Escherichia coli SE15 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|405955.13.peg.2260
Escherichia coli APEC O1 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|405955.9.peg.1843
Escherichia coli APEC O1 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|199310.1.peg.2532
Escherichia coli CFT073 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|199310.4.peg.2446
Escherichia coli CFT073 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|714962.3.peg.2348
Escherichia coli IHE3034 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|749546.3.peg.2833
Escherichia coli MS 185-1 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|749527.3.peg.1512
Escherichia coli MS 21-1 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|749531.3.peg.2069
Escherichia coli MS 69-1 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|585035.6.peg.2154
Escherichia coli S88 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|439855.10.peg.1143
Escherichia coli SMS-3-5 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|656440.3.peg.2059
Escherichia coli TA206 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|869729.3.peg.1363
Escherichia coli UM146 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|364106.7.peg.2375
Escherichia coli UTI89 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|364106.8.peg.2378
Escherichia coli UTI89 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|562.376.peg.3981
Escherichia coli WV_060327 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|525281.3.peg.3878
Escherichia coli 83972 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|655817.3.peg.2518
Escherichia coli ABU 83972 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|340186.3.peg.2458
Escherichia coli E110019 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|340186.5.peg.2537
Escherichia coli E110019 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|679205.4.peg.2972
Escherichia coli MS 124-1 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|749533.3.peg.436
Escherichia coli MS 84-1 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|216593.1.peg.2687
Escherichia coli E2348/69 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
E
R
IIA
A
-
---
Y
GQG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|574521.7.peg.2266
Escherichia coli O127:H6 str. E2348/69 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
E
R
IIA
A
-
---
Y
GQG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|753642.3.peg.3016
Escherichia coli NC101 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
ISII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
A
KSRFARHEEEA
fig|216592.1.peg.2869
Escherichia coli 042 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TT
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
Q
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|216592.3.peg.2415
Escherichia coli 042 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TT
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
Q
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|670888.3.peg.4212
Escherichia coli 1827-70 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|344610.3.peg.2093
Escherichia coli 53638 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|344610.7.peg.4398
Escherichia coli 53638 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|481805.3.peg.1678
Escherichia coli ATCC 8739 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|481805.6.peg.1673
Escherichia coli ATCC 8739 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|595496.3.peg.2043
Escherichia coli BW2952 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|536056.3.peg.1670
Escherichia coli DH1 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|656393.3.peg.3099
Escherichia coli H299 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|83333.1.peg.2051
Escherichia coli K12 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|595495.4.peg.2945
Escherichia coli KO11 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|656419.3.peg.2830
Escherichia coli M718 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|566546.3.peg.2499
Escherichia coli W (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|566546.4.peg.2219
Escherichia coli W (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|316407.3.peg.2011
Escherichia coli W3110 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|316385.5.peg.2190
Escherichia coli str. K-12 substr. DH10B (369-1023/1023)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|316385.7.peg.2240
Escherichia coli str. K-12 substr. DH10B (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|511145.12.peg.2152
Escherichia coli str. K-12 substr. MG1655 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|511145.6.peg.2137
Escherichia coli str. K-12 substr. MG1655 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|331112.3.peg.2073
Escherichia coli HS (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|331112.6.peg.2168
Escherichia coli HS (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|749538.3.peg.1296
Escherichia coli MS 116-1 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|585397.7.peg.2437
Escherichia coli ED1a (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
PRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|585397.9.peg.2435
Escherichia coli ED1a (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
PRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|358709.5.peg.523
Escherichia coli 101-1 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
E
L
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|413997.3.peg.2072
Escherichia coli B str. REL606 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
E
L
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|511693.5.peg.2103
Escherichia coli BL21 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
E
L
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|469008.4.peg.1629
Escherichia coli BL21(DE3) (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
E
L
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|749547.3.peg.3117
Escherichia coli MS 187-1 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
E
L
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|749548.3.peg.2930
Escherichia coli MS 196-1 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
E
L
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|749549.3.peg.1282
Escherichia coli MS 198-1 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
E
L
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|670897.3.peg.2991
Escherichia coli 2362-75 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
NGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
E
R
IIA
A
-
---
Y
GQG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|585057.4.peg.992
Escherichia coli IAI39 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
T
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
VEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|585057.6.peg.989
Escherichia coli IAI39 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
T
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
VEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|749528.3.peg.1606
Escherichia coli MS 45-1 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFI
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
G
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|685038.3.peg.2129
Escherichia coli O83:H1 str. NRG 857C (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
D
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|701177.3.peg.2620
Escherichia coli O55:H7 str. CB9615 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KV
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
F
L
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|316401.4.peg.2539
Escherichia coli ETEC H10407 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
P
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|749540.3.peg.199
Escherichia coli MS 146-1 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
T
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|340197.3.peg.135
Escherichia coli F11 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
P
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|340197.5.peg.139
Escherichia coli F11 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
P
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|749550.3.peg.1588
Escherichia coli MS 200-1 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
P
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|340184.3.peg.3957
Escherichia coli B7A (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEI
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KV
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|340184.6.peg.4139
Escherichia coli B7A (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEI
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KV
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|749537.3.peg.892
Escherichia coli MS 115-1 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEI
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KV
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|585396.4.peg.2889
Escherichia coli O111:H- str. 11128 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEI
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KV
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|573235.3.peg.3050
Escherichia coli O26:H11 str. 11368 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEI
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KV
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|409438.11.peg.2499
Escherichia coli SE11 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEI
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KV
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|656379.3.peg.2607
Escherichia coli FVEC1302 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
E
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
T
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
N
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|656380.3.peg.2167
Escherichia coli FVEC1412 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
E
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
T
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
N
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|656437.3.peg.2336
Escherichia coli TA143 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
E
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
T
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
N
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|585056.7.peg.2594
Escherichia coli UMN026 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
E
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
T
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
N
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|550676.3.peg.2372
Escherichia coli B185 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LK
L
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
LV
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|340185.3.peg.1199
Escherichia coli E22 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEI
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KV
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|340185.4.peg.1265
Escherichia coli E22 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEI
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KV
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|585395.4.peg.2670
Escherichia coli O103:H2 str. 12009 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEI
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KV
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|344601.3.peg.3240
Escherichia coli B171 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEI
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KV
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
P
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|344601.5.peg.3386
Escherichia coli B171 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVF
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEI
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KV
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
P
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
LIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
EA
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|550677.3.peg.1624
Escherichia coli B354 (386-1040/1040)
M
V
F
L
D
F
S
I
N
N
LTL
M
AL
T
IA
T
G
F
VVDDAIVVIEN
IS
R
Y
I
-
E
K
G
EK
P
LA
A
A
L
KGAG
----------
EIG
F
T
I
ISLTFS
L
I
AV
L
IPL
LFM
G
D
IV
GRL
F
R
E
FA
I
T
LAV
A
I
LI
S
A
V
V
S
L
T
LTP
M
M
C
A
RM
L
SQES
L
R
K
-----
Q
NRFSRASEKM
F
D
R
IIA
A
-
---
Y
GRG
L
A
KVL
N
HPWLTLS
V
ALST
L
LLS
V
L
L
WVL
IP
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
SS
S
F
A
NMAQRQ
R
QVA
D
--
V
I
LQD
P
A
V
QS
LT
SF
V
G
VDGTNPSL
N
SAR
L
Q
---
I
N
LKP
LD
ER
D--
-
D
R
VQK
V
I
A
RL
QTAVDKVPG
V
D
L
FLQ
P
TQDLT
I
DTQV
S
RTQYQFT
L
QA
-
-
-
TS
L
D
AL
STWVP
QL
MEK
L
QQL
P
Q
L
S
D
V
SS
D
W
Q
D
K
G
LVAY
V
NV
DR
DS
A
S
RLGI
S
M
A
D
VDNA
L
Y
NA
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLA
AL
DTIR
L
T
S
SD
G
GV
V
PLS
SI
A
KI
E
QRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
LG
DA
VQA
I
MDTE
K
T
L
NL
P
VDITTQFQ
G
S
T
LA
FQ
SAL
-----
GS--TVW
L
IVA
A
V
VA
M
Y
I
V
L
GI
LYES
FIH
P
IT
ILS
T
LP
T
A
G
VGALLAL
MIA
G
SEL
DV
IAII
G
I
I
L
LIGI
V
K
KNAIMM
I
D
F
---
A
L
A
A
EREQ
G
-------
MS
P
R
D
A
IY
Q
AC
L
LR
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
A
E
LRRP
LG
IG
MVGG
L
I
V
S
Q
V
LTLF
TT
P
VI
Y
L
LFDRLALW
T
KSRFARHEEEA
fig|316385.5.peg.2191
Escherichia coli str. K-12 substr. DH10B (298-942/946)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|340186.3.peg.2459
Escherichia coli E110019 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
VI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|340186.5.peg.2538
Escherichia coli E110019 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
VI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|331111.12.peg.2648
Escherichia coli E24377A (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
VI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|331111.3.peg.110
Escherichia coli E24377A (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
VI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|749545.3.peg.9
Escherichia coli MS 182-1 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
VI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|749532.3.peg.4102
Escherichia coli MS 78-1 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
VI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|585396.4.peg.2890
Escherichia coli O111:H- str. 11128 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
VI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|573235.3.peg.3051
Escherichia coli O26:H11 str. 11368 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
VI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|656408.3.peg.2279
Escherichia coli H591 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
VI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|749527.3.peg.1511
Escherichia coli MS 21-1 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
I
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|344601.3.peg.3239
Escherichia coli B171 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRM-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|344601.5.peg.3385
Escherichia coli B171 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRM-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|562.371.peg.4281
Escherichia coli 1044A (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGM
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
K
S
KQ
fig|562.373.peg.4606
Escherichia coli 1125A (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGM
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
K
S
KQ
fig|83334.1.peg.2888
Escherichia coli O157:H7 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGM
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
K
S
KQ
fig|444454.5.peg.1748
Escherichia coli O157:H7 str. EC4024 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGM
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
K
S
KQ
fig|444449.5.peg.1224
Escherichia coli O157:H7 str. EC4042 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGM
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
K
S
KQ
fig|444448.5.peg.5498
Escherichia coli O157:H7 str. EC4045 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGM
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
K
S
KQ
fig|444453.5.peg.3717
Escherichia coli O157:H7 str. EC4076 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGM
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
K
S
KQ
fig|444452.5.peg.3368
Escherichia coli O157:H7 str. EC4113 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGM
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
K
S
KQ
fig|444450.8.peg.3018
Escherichia coli O157:H7 str. EC4115 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGM
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
K
S
KQ
fig|444451.5.peg.3057
Escherichia coli O157:H7 str. EC4196 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGM
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
K
S
KQ
fig|444447.5.peg.119
Escherichia coli O157:H7 str. EC4206 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGM
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
K
S
KQ
fig|478004.5.peg.4590
Escherichia coli O157:H7 str. EC4401 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGM
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
K
S
KQ
fig|478005.5.peg.3684
Escherichia coli O157:H7 str. EC4486 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGM
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
K
S
KQ
fig|478006.5.peg.2303
Escherichia coli O157:H7 str. EC4501 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGM
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
K
S
KQ
fig|478007.5.peg.1816
Escherichia coli O157:H7 str. EC508 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGM
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
K
S
KQ
fig|478008.5.peg.3902
Escherichia coli O157:H7 str. EC869 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGM
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
K
S
KQ
fig|637388.3.peg.2193
Escherichia coli O157:H7 str. FRIK2000 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGM
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
K
S
KQ
fig|570506.3.peg.3473
Escherichia coli O157:H7 str. FRIK966 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGM
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
K
S
KQ
fig|386585.9.peg.3016
Escherichia coli O157:H7 str. Sakai (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGM
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
K
S
KQ
fig|544404.4.peg.2880
Escherichia coli O157:H7 str. TW14359 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGM
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
K
S
KQ
fig|502346.5.peg.4501
Escherichia coli O157:H7 str. TW14588 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGM
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
K
S
KQ
fig|656419.3.peg.2831
Escherichia coli M718 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
L
T
AL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|340185.3.peg.1200
Escherichia coli E22 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRM-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|340185.4.peg.1266
Escherichia coli E22 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRM-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|585395.4.peg.2671
Escherichia coli O103:H2 str. 12009 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRM-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|749540.3.peg.198
Escherichia coli MS 146-1 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWKP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PTN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|550672.3.peg.1795
Escherichia coli B088 (298-942/946)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|749538.3.peg.1297
Escherichia coli MS 116-1 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRHP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|155864.1.peg.2892
Escherichia coli O157:H7 EDL933 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGM
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
K
S
KQ
fig|155864.8.peg.2776
Escherichia coli O157:H7 EDL933 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGM
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
K
S
KQ
fig|358709.5.peg.524
Escherichia coli 101-1 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|344610.3.peg.2094
Escherichia coli 53638 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|344610.7.peg.4397
Escherichia coli 53638 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|481805.3.peg.1677
Escherichia coli ATCC 8739 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|481805.6.peg.1672
Escherichia coli ATCC 8739 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|413997.3.peg.2073
Escherichia coli B str. REL606 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|511693.5.peg.2104
Escherichia coli BL21 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|469008.4.peg.1628
Escherichia coli BL21(DE3) (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|595496.3.peg.2044
Escherichia coli BW2952 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|536056.3.peg.1669
Escherichia coli DH1 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|83333.1.peg.2052
Escherichia coli K12 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|749548.3.peg.2931
Escherichia coli MS 196-1 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|749549.3.peg.1281
Escherichia coli MS 198-1 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|316407.3.peg.2012
Escherichia coli W3110 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|316385.7.peg.2241
Escherichia coli str. K-12 substr. DH10B (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|511145.12.peg.2153
Escherichia coli str. K-12 substr. MG1655 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|511145.6.peg.2138
Escherichia coli str. K-12 substr. MG1655 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|749531.3.peg.2068
Escherichia coli MS 69-1 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|562.372.peg.5779
Escherichia coli 1212A (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSI
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGM
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
K
S
KQ
fig|562.374.peg.1791
Escherichia coli 536A (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSI
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGM
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
K
S
KQ
fig|316401.4.peg.2540
Escherichia coli ETEC H10407 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|656414.3.peg.2435
Escherichia coli H736 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|585034.4.peg.2127
Escherichia coli IAI1 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|585034.5.peg.2122
Escherichia coli IAI1 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|679207.4.peg.3867
Escherichia coli MS 107-1 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|749537.3.peg.891
Escherichia coli MS 115-1 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|679206.4.peg.1592
Escherichia coli MS 119-7 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|679204.3.peg.106
Escherichia coli MS 145-7 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|749544.3.peg.958
Escherichia coli MS 175-1 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|409438.11.peg.2500
Escherichia coli SE11 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|656443.3.peg.2774
Escherichia coli TA271 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|656393.3.peg.3100
Escherichia coli H299 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
N
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|679205.4.peg.2971
Escherichia coli MS 124-1 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
N
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|749533.3.peg.435
Escherichia coli MS 84-1 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
N
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|562.375.peg.2296
Escherichia coli EC4100B (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDFR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|595495.4.peg.2944
Escherichia coli KO11 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAI
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|566546.3.peg.2498
Escherichia coli W (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAI
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|566546.4.peg.2220
Escherichia coli W (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAI
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|216592.1.peg.2870
Escherichia coli 042 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTS
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQ
S
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|216592.3.peg.2416
Escherichia coli 042 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTS
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQ
S
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|656437.3.peg.2337
Escherichia coli TA143 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRSKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
TEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|701177.3.peg.2621
Escherichia coli O55:H7 str. CB9615 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
T
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
ND
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|585057.4.peg.991
Escherichia coli IAI39 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
VLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
L
P
AL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|585057.6.peg.988
Escherichia coli IAI39 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
VLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
L
P
AL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|6666666.5357.peg.268
Escherichia coli TY-2482 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|585055.6.peg.2367
Escherichia coli 55989 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|585055.8.peg.2374
Escherichia coli 55989 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|331112.3.peg.2074
Escherichia coli HS (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
F
T
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRHP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|331112.6.peg.2169
Escherichia coli HS (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
F
T
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRHP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|362663.8.peg.2127
Escherichia coli 536 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGA
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|362663.9.peg.2132
Escherichia coli 536 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGA
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|199310.1.peg.2533
Escherichia coli CFT073 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGA
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|199310.4.peg.2447
Escherichia coli CFT073 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGA
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|340197.3.peg.136
Escherichia coli F11 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGA
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|340197.5.peg.140
Escherichia coli F11 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGA
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|749546.3.peg.2834
Escherichia coli MS 185-1 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGA
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|749550.3.peg.1587
Escherichia coli MS 200-1 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGA
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|749528.3.peg.1605
Escherichia coli MS 45-1 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGA
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|685038.3.peg.2130
Escherichia coli O83:H1 str. NRG 857C (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGA
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|656440.3.peg.2060
Escherichia coli TA206 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGA
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|749547.3.peg.3116
Escherichia coli MS 187-1 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GS
D
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|439855.10.peg.1142
Escherichia coli SMS-3-5 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|1040638.4.peg.3158
Escherichia coli O104:H4 str. LB226692 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|550677.3.peg.1625
Escherichia coli B354 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|656444.3.peg.3049
Escherichia coli TA280 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|753642.3.peg.3015
Escherichia coli NC101 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
K
-----
Q
TRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
M
-
-
--
RF
S
R
KPKQ
A
fig|714962.3.peg.2349
Escherichia coli IHE3034 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
QLF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|869729.3.peg.1362
Escherichia coli UM146 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
QLF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|364106.7.peg.2376
Escherichia coli UTI89 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
QLF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|364106.8.peg.2379
Escherichia coli UTI89 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
QLF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|550676.3.peg.2373
Escherichia coli B185 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
M
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NVSYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|562.376.peg.3984
Escherichia coli WV_060327 (319-964/967)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
VLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|656379.3.peg.2608
Escherichia coli FVEC1302 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
G
L
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
HD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|656380.3.peg.2168
Escherichia coli FVEC1412 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
G
L
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
HD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|585056.7.peg.2595
Escherichia coli UMN026 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
G
L
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
HD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
S
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|525281.3.peg.3879
Escherichia coli 83972 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
E
A
SAA
I
DRAM
T
Q
L
GV
P
SSVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|655817.3.peg.2519
Escherichia coli ABU 83972 (377-1021/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RD
ER
S--
-
E
T
AQQ
II
D
RL
RVKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
Q
D
N
G
AEMN
L
VY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
E
A
SAA
I
DRAM
T
Q
L
GV
P
SSVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
fig|670897.3.peg.2992
Escherichia coli 2362-75 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|216593.1.peg.2686
Escherichia coli E2348/69 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|656417.3.peg.2743
Escherichia coli M605 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|574521.7.peg.2267
Escherichia coli O127:H6 str. E2348/69 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|431946.3.peg.2049
Escherichia coli SE15 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
M
-
-
--
RF
S
R
KPKQ
A
fig|585397.7.peg.2438
Escherichia coli ED1a (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGA
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDE
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|585397.9.peg.2436
Escherichia coli ED1a (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGA
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDE
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|562.376.peg.3982
Escherichia coli WV_060327 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
VLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
ELF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
D
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|405955.13.peg.2261
Escherichia coli APEC O1 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
QLF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
Y
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|405955.9.peg.1844
Escherichia coli APEC O1 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
QLF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
Y
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|585035.6.peg.2155
Escherichia coli S88 (377-1022/1025)
M
Y
L
C
G
F
S
L
N
N
L
S
L
M
AL
T
IA
T
G
F
VVDDAIVV
L
EN
IA
R
H
L
-
E
A
G
MK
P
LQ
A
A
L
QGTR
----------
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
PL
LLM
GG
LP
GRL
L
R
E
FA
V
T
LSV
A
I
GI
S
L
LV
S
L
T
LTP
M
M
CG
WM
L
KASK
P
R
E
-----
Q
KRL-----RG
F
G
R
MLV
A
L
QQG
Y
GKS
L
K
W
VL
N
HTRLVGV
V
LLGT
I
ALN
I
W
L
YIS
IP
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
IS
F
Q
AMRGKL
Q
DFM
K
--
I
I
RDD
P
A
V
DN
V
T
GF
TG
----GSRV
N
SGM
M
F
---
I
T
LKP
RG
ER
S--
-
E
T
AQQ
II
D
RL
RKKLAKEPG
A
N
L
FLM
A
VQDIR
V
GGRQ
A
NASYQYT
L
LS
-
-
-
DD
LAAL
REWEP
KI
RKK
L
ATL
P
E
LA
D
V
NS
D
Q
E
D
N
G
AEMN
L
IY
DR
DT
M
A
RLGI
D
V
Q
A
ANSL
L
N
NA
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
M
E
VDPRY
T
QDIS
AL
EKMF
V
I
N
NE
G
KA
IPLS
YF
A
KW
Q
PAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
LS
DA
SAA
I
DRAM
T
Q
L
GV
P
STVRGSFA
GTA
QV
FQ
ETM
-----
NS--QVI
L
IIA
A
I
AT
V
Y
I
V
L
GI
LYES
YVH
P
LT
ILS
T
LP
S
A
G
VGALLAL
QLF
N
APF
SL
IALI
G
I
M
L
LIGI
V
K
KNAIMMV
Y
F
---
A
L
EA
QRHG
N
-------
LT
P
Q
EA
IF
Q
AC
L
LR
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
LG
IT
I
VGG
LV
M
S
Q
LLTL
Y
TT
P
VV
Y
L
F
FDRL
R
L
-
-
--
RF
S
R
KPKQ
A
fig|656444.3.peg.3458
Escherichia coli TA280 (388-1026/1035)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
-
-
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|340197.3.peg.3049
Escherichia coli F11 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
HK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|340197.5.peg.3187
Escherichia coli F11 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
HK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|1040638.4.peg.2882
Escherichia coli O104:H4 str. LB226692 (119-759/768)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|6666666.5357.peg.4416
Escherichia coli TY-2482 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|670897.3.peg.3434
Escherichia coli 2362-75 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|585055.6.peg.2782
Escherichia coli 55989 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|585055.8.peg.2786
Escherichia coli 55989 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|405955.13.peg.2715
Escherichia coli APEC O1 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|405955.9.peg.2235
Escherichia coli APEC O1 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|550676.3.peg.1663
Escherichia coli B185 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|550677.3.peg.2332
Escherichia coli B354 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|340186.3.peg.1585
Escherichia coli E110019 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|340186.5.peg.1634
Escherichia coli E110019 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|340185.3.peg.3122
Escherichia coli E22 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|340185.4.peg.3285
Escherichia coli E22 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|585034.4.peg.2485
Escherichia coli IAI1 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|585034.5.peg.2483
Escherichia coli IAI1 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|585057.4.peg.2710
Escherichia coli IAI39 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|585057.6.peg.2713
Escherichia coli IAI39 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|714962.3.peg.2822
Escherichia coli IHE3034 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|656417.3.peg.3145
Escherichia coli M605 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|656419.3.peg.3228
Escherichia coli M718 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|749550.3.peg.5137
Escherichia coli MS 200-1 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|749527.3.peg.4775
Escherichia coli MS 21-1 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|753642.3.peg.2636
Escherichia coli NC101 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|585395.4.peg.3117
Escherichia coli O103:H2 str. 12009 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|585035.6.peg.2620
Escherichia coli S88 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|431946.3.peg.2428
Escherichia coli SE15 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|439855.10.peg.2775
Escherichia coli SMS-3-5 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|656437.3.peg.2792
Escherichia coli TA143 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|869729.3.peg.928
Escherichia coli UM146 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|364106.7.peg.2801
Escherichia coli UTI89 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|364106.8.peg.2801
Escherichia coli UTI89 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|562.376.peg.4385
Escherichia coli WV_060327 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|670888.3.peg.3828
Escherichia coli 1827-70 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
K
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|525281.3.peg.4252
Escherichia coli 83972 (328-968/977)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
TFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NSE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|655817.3.peg.2900
Escherichia coli ABU 83972 (328-968/977)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
TFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NSE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|199310.1.peg.2922
Escherichia coli CFT073 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
TFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NSE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|199310.4.peg.2827
Escherichia coli CFT073 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
TFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NSE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|749528.3.peg.2359
Escherichia coli MS 45-1 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
TFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NSE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|749531.3.peg.2713
Escherichia coli MS 69-1 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
T
E
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|585397.7.peg.2914
Escherichia coli ED1a (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NSE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|585397.9.peg.2911
Escherichia coli ED1a (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NSE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|685038.3.peg.2506
Escherichia coli O83:H1 str. NRG 857C (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NSE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|679205.4.peg.1336
Escherichia coli MS 124-1 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVT
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
D
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|749533.3.peg.1535
Escherichia coli MS 84-1 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVT
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
D
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|550672.3.peg.2189
Escherichia coli B088 (260-900/909)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
D
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|340184.3.peg.2721
Escherichia coli B7A (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
D
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|340184.6.peg.2848
Escherichia coli B7A (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
D
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|562.375.peg.3443
Escherichia coli EC4100B (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
D
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|656408.3.peg.2751
Escherichia coli H591 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
D
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|595495.4.peg.2507
Escherichia coli KO11 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
D
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|679206.4.peg.651
Escherichia coli MS 119-7 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
D
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|749532.3.peg.3273
Escherichia coli MS 78-1 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
D
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|409438.11.peg.2918
Escherichia coli SE11 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
D
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|566546.3.peg.2692
Escherichia coli W (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
D
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|566546.4.peg.2662
Escherichia coli W (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
D
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|216592.1.peg.5437
Escherichia coli 042 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
S
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|216592.3.peg.2793
Escherichia coli 042 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
S
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|656393.3.peg.3483
Escherichia coli H299 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
M
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|155864.8.peg.3235
Escherichia coli O157:H7 EDL933 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTXKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|331112.3.peg.2439
Escherichia coli HS (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
IT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
T
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|331112.6.peg.2543
Escherichia coli HS (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
IT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
T
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|679207.4.peg.2750
Escherichia coli MS 107-1 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
I
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
D
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|679204.3.peg.1632
Escherichia coli MS 145-7 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LVL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
D
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|749548.3.peg.1997
Escherichia coli MS 196-1 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKGV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|216593.1.peg.2195
Escherichia coli E2348/69 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GLHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|574521.7.peg.2753
Escherichia coli O127:H6 str. E2348/69 (260-900/909)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GLHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|562.371.peg.5329
Escherichia coli 1044A (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|562.373.peg.3655
Escherichia coli 1125A (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|562.372.peg.1878
Escherichia coli 1212A (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|562.374.peg.3080
Escherichia coli 536A (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|481805.3.peg.1293
Escherichia coli ATCC 8739 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|481805.6.peg.1292
Escherichia coli ATCC 8739 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|413997.3.peg.2471
Escherichia coli B str. REL606 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|511693.5.peg.2483
Escherichia coli BL21 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|469008.4.peg.1253
Escherichia coli BL21(DE3) (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|595496.3.peg.2446
Escherichia coli BW2952 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|536056.3.peg.1263
Escherichia coli DH1 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|316401.4.peg.2937
Escherichia coli ETEC H10407 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|656414.3.peg.2834
Escherichia coli H736 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|83333.1.peg.2438
Escherichia coli K12 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|749538.3.peg.4763
Escherichia coli MS 116-1 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|749540.3.peg.1070
Escherichia coli MS 146-1 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|749544.3.peg.2847
Escherichia coli MS 175-1 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|749547.3.peg.2320
Escherichia coli MS 187-1 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|585396.4.peg.3291
Escherichia coli O111:H- str. 11128 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|83334.1.peg.3329
Escherichia coli O157:H7 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|155864.1.peg.3330
Escherichia coli O157:H7 EDL933 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|444454.5.peg.2351
Escherichia coli O157:H7 str. EC4024 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|444449.5.peg.1816
Escherichia coli O157:H7 str. EC4042 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|444448.5.peg.570
Escherichia coli O157:H7 str. EC4045 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|444453.5.peg.52
Escherichia coli O157:H7 str. EC4076 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|444452.5.peg.1540
Escherichia coli O157:H7 str. EC4113 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|444450.8.peg.3659
Escherichia coli O157:H7 str. EC4115 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|444451.5.peg.1310
Escherichia coli O157:H7 str. EC4196 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|444447.5.peg.710
Escherichia coli O157:H7 str. EC4206 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|478004.5.peg.2971
Escherichia coli O157:H7 str. EC4401 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|478005.5.peg.2541
Escherichia coli O157:H7 str. EC4486 (328-968/977)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|478006.5.peg.1579
Escherichia coli O157:H7 str. EC4501 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|478007.5.peg.1624
Escherichia coli O157:H7 str. EC508 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|478008.5.peg.3015
Escherichia coli O157:H7 str. EC869 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|637388.3.peg.131
Escherichia coli O157:H7 str. FRIK2000 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|570506.3.peg.5202
Escherichia coli O157:H7 str. FRIK966 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|386585.9.peg.3479
Escherichia coli O157:H7 str. Sakai (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|544404.4.peg.3462
Escherichia coli O157:H7 str. TW14359 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|502346.5.peg.3954
Escherichia coli O157:H7 str. TW14588 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|573235.3.peg.3579
Escherichia coli O26:H11 str. 11368 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|701177.3.peg.3023
Escherichia coli O55:H7 str. CB9615 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|316407.3.peg.2391
Escherichia coli W3110 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|316385.5.peg.2600
Escherichia coli str. K-12 substr. DH10B (328-968/977)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|316385.7.peg.2658
Escherichia coli str. K-12 substr. DH10B (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|511145.12.peg.2564
Escherichia coli str. K-12 substr. MG1655 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|511145.6.peg.2550
Escherichia coli str. K-12 substr. MG1655 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|749545.3.peg.420
Escherichia coli MS 182-1 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
PT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
D
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|656379.3.peg.3043
Escherichia coli FVEC1302 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
H
E
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|656380.3.peg.2543
Escherichia coli FVEC1412 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
H
E
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|749549.3.peg.1756
Escherichia coli MS 198-1 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
H
E
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|585056.7.peg.2966
Escherichia coli UMN026 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
H
E
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|749546.3.peg.459
Escherichia coli MS 185-1 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
TFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NSE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
RSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|358709.5.peg.2250
Escherichia coli 101-1 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QPLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|331111.12.peg.3018
Escherichia coli E24377A (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
E
Q
RK
A
Q
A
LG
V
D
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|331111.3.peg.472
Escherichia coli E24377A (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
E
Q
RK
A
Q
A
LG
V
D
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|362663.8.peg.2511
Escherichia coli 536 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IIA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
V
R
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|362663.9.peg.2516
Escherichia coli 536 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IIA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
V
R
DSK
T
G
T
SFA
II
E
R
A
TKAFNKIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
A
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|344610.3.peg.415
Escherichia coli 53638 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
R
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
T
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|344610.7.peg.3865
Escherichia coli 53638 (388-1028/1037)
Y
S
V
N
T
LT
M
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
S
E
E
G
LT
P
RE
AT
R
KSMG
----------
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
P
M
AFF
GG
TT
G
AI
Y
R
Q
F
S
I
T
IVA
AM
VL
S
V
LVA
M
I
LTP
A
LC
A
TL
L
K--P
L
K
K
GEHHG
Q
KGFFAWFNQM
F
N
R
NAE
R
-
---
Y
EKG
V
A
K
I
LH
RSLRWIV
I
YVLL
L
GGM
V
F
L
FLR
L
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
ST
Q
Q
QTLKVV
E
QIE
K
YY
F
T
HEK
D
N
I
MS
VF
AT
V
G
SGPGGNGQ
N
VAR
M
F
---
I
R
LK
D
WS
ER
DSK
T
G
T
SFA
II
E
R
A
TKAFNQIKE
A
R
V
I--
A
SSPPA
I
SGLG
S
SAGFDME
L
QD
H
A
G
AG
HD
AL
MAARN
QL
LAL
A
AEN
P
E
L
T
R
V
RH
N
G
LD
D
S
PQLQ
I
DI
D
Q
RK
A
Q
A
LG
V
A
I
D
D
INDT
L
Q
T
A
R
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPD
DI
NLWY
V
R
N
KD
G
GM
V
P
F
S
AF
A
TS
R
WET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
TG
T
T
MDI
M
ESLV
K
Q
L
--
P
NGFG--LE
W
TA
MS
Y
Q
ERL
-----
SGAQAPA
L
YAI
S
L
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
M
L
V
V
P
L
G
V
I
GALLA
T
WMR
G
LEN
DV
YFQV
G
L
L
T
V
IG
L
S
AKNAI
L
I
V
E
F
---
A
N
E
M
NQK-
G
-------
HD
L
F
EA
TL
HAC
R
Q
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
STG
A
GS
G
GQHA
V
G
TG
VM
GGMI
S
A
T
I
L
A
IY
FV
P
LF
F
V
L
VR
R
fig|585057.4.peg.1712
Escherichia coli IAI39 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QQG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|585057.6.peg.1712
Escherichia coli IAI39 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QQG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|562.373.peg.5239
Escherichia coli 1125A (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
K
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIVLV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFDRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YLVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
S
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|199310.1.peg.1711
Escherichia coli CFT073 (354-996/1005)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|550676.3.peg.848
Escherichia coli B185 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YLVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|656419.3.peg.1639
Escherichia coli M718 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YLVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|656417.3.peg.1603
Escherichia coli M605 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|216593.1.peg.1927
Escherichia coli E2348/69 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|574521.7.peg.1509
Escherichia coli O127:H6 str. E2348/69 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|362663.8.peg.1356
Escherichia coli 536 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|362663.9.peg.1356
Escherichia coli 536 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|525281.3.peg.128
Escherichia coli 83972 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|655817.3.peg.1652
Escherichia coli ABU 83972 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|550677.3.peg.2753
Escherichia coli B354 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|199310.4.peg.1640
Escherichia coli CFT073 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|340197.3.peg.1121
Escherichia coli F11 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|340197.5.peg.1182
Escherichia coli F11 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|656393.3.peg.2062
Escherichia coli H299 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|749546.3.peg.265
Escherichia coli MS 185-1 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|749550.3.peg.61
Escherichia coli MS 200-1 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|749528.3.peg.176
Escherichia coli MS 45-1 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|685038.3.peg.1335
Escherichia coli O83:H1 str. NRG 857C (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|439855.10.peg.1994
Escherichia coli SMS-3-5 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|562.376.peg.3163
Escherichia coli WV_060327 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|670897.3.peg.2458
Escherichia coli 2362-75 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|749527.3.peg.410
Escherichia coli MS 21-1 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGT
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|753642.3.peg.1821
Escherichia coli NC101 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|431946.3.peg.1319
Escherichia coli SE15 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|405955.13.peg.1406
Escherichia coli APEC O1 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
AD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|405955.9.peg.1156
Escherichia coli APEC O1 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
AD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|714962.3.peg.1532
Escherichia coli IHE3034 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
AD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|585035.6.peg.1423
Escherichia coli S88 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
AD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|364106.7.peg.1603
Escherichia coli UTI89 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
AD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|364106.8.peg.1603
Escherichia coli UTI89 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
AD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|585397.7.peg.1507
Escherichia coli ED1a (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
Q
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
PE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RTARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|585397.9.peg.1501
Escherichia coli ED1a (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
Q
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
PE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RTARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|656444.3.peg.2023
Escherichia coli TA280 (364-1006/1015)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
I
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
SAPS
D
L
GKWF
V
R
G
SD
N
AM
T
P
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|749531.3.peg.294
Escherichia coli MS 69-1 (384-1026/1035)
L
A
L
F
G
Y
S
I
N
T
LTL
F
A
M
V
L
A
I
G
L
L
VDDAIVV
V
EN
VE
R
I
M
R
D
E
G
LP
A
RE
AT
E
KSMG
----------
EI
S
G
AL
VAIALV
L
S
AVF
L
P
M
AFF
GG
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
V
V
VAL
T
LTP
A
LCG
SV
L
QHVP
P
H
K
-----
-
KGFFGAFNRF
Y
R
R
TED
K
-
---
Y
QRG
V
I
Y
VL
R
RAARTMG
L
YVVL
G
GGM
A
L
M
MWK
L
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
A
A
RTAEVN
R
QIV
D
WF
L
I
NEK
A
N
T
DV
I
F
TV
D
G
FSFSGSGQ
N
TGM
A
F
---
V
S
LK
N
WS
Q
R
KGA
E
N
T
AQA
I
A
L
R
A
TKELGTIRD
A
T
V
F--
A
MTPPA
V
DGLG
Q
SNGFTFE
L
LA
N
G
G
TD
RET
L
LQMRN
QL
IEK
A
NQS
P
E
L
H
S
V
RA
N
D
L
P
Q
M
PQLQ
V
DI
D
S
NK
A
V
S
LG
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
IQ
GDSEF
R
STPS
D
L
GKWF
V
R
G
SD
N
AM
TL
F
S
AF
A
TT
R
WLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
SG
DA
MTK
M
EELA
N
S
L
--
P
AGTT--WA
WS
G
LS
L
Q
EKL
-----
ASGQALS
L
YAV
SI
LV
VF
L
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
GA
A
LA
A
WMR
D
LNN
DV
YFQV
A
L
L
T
T
IG
L
S
S
KNAI
L
I
V
E
F
---
A
E
A
A
VAE-
G
-------
YS
L
S
R
A
AL
R
A
A
Q
T
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TG
A
G
A
N
SRIA
I
G
TG
II
GG
T
L
T
A
T
LL
A
I
F
FV
P
LF
F
V
L
V
K
RL
fig|362663.8.peg.608
Escherichia coli 536 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VSE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|362663.9.peg.609
Escherichia coli 536 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VSE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|340197.3.peg.2412
Escherichia coli F11 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VSE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|340197.5.peg.2530
Escherichia coli F11 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VSE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|749550.3.peg.4627
Escherichia coli MS 200-1 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VSE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|749527.3.peg.4942
Escherichia coli MS 21-1 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AQ
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
K
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|679207.4.peg.2892
Escherichia coli MS 107-1 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|749537.3.peg.4060
Escherichia coli MS 115-1 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|585396.4.peg.625
Escherichia coli O111:H- str. 11128 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|573235.3.peg.654
Escherichia coli O26:H11 str. 11368 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|525281.3.peg.2364
Escherichia coli 83972 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|655817.3.peg.665
Escherichia coli ABU 83972 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|585397.7.peg.568
Escherichia coli ED1a (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|585397.9.peg.570
Escherichia coli ED1a (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|656393.3.peg.1249
Escherichia coli H299 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETTTDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|585057.4.peg.586
Escherichia coli IAI39 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|585057.6.peg.584
Escherichia coli IAI39 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|656417.3.peg.694
Escherichia coli M605 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|749546.3.peg.3398
Escherichia coli MS 185-1 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|749528.3.peg.4064
Escherichia coli MS 45-1 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|753642.3.peg.1083
Escherichia coli NC101 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|685038.3.peg.517
Escherichia coli O83:H1 str. NRG 857C (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|585035.6.peg.608
Escherichia coli S88 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|439855.10.peg.762
Escherichia coli SMS-3-5 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|562.376.peg.2042
Escherichia coli WV_060327 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|316401.4.peg.692
Escherichia coli ETEC H10407 (381-1037/1047)
M
P
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
A
M
L
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|431946.3.peg.521
Escherichia coli SE15 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
L
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|656440.3.peg.427
Escherichia coli TA206 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTA
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|714962.3.peg.600
Escherichia coli IHE3034 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
AMGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|869729.3.peg.3132
Escherichia coli UM146 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
AMGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|364106.7.peg.680
Escherichia coli UTI89 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
AMGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|364106.8.peg.678
Escherichia coli UTI89 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
AMGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|656379.3.peg.1353
Escherichia coli FVEC1302 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
I
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
A
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|656380.3.peg.1181
Escherichia coli FVEC1412 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
I
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
A
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|749549.3.peg.4797
Escherichia coli MS 198-1 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
I
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
A
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|585056.7.peg.862
Escherichia coli UMN026 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
I
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
A
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|216592.1.peg.326
Escherichia coli 042 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|216592.3.peg.634
Escherichia coli 042 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|340186.3.peg.2228
Escherichia coli E110019 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|340186.5.peg.2300
Escherichia coli E110019 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|656414.3.peg.748
Escherichia coli H736 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|749540.3.peg.485
Escherichia coli MS 146-1 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|656437.3.peg.647
Escherichia coli TA143 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
I
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
A
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
M
L
S
LF
II
P
AA
Y
K
L
fig|344601.3.peg.2299
Escherichia coli B171 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
S
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
Q
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|344601.5.peg.2400
Escherichia coli B171 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
S
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
Q
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|199310.1.peg.636
Escherichia coli CFT073 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
XNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|199310.4.peg.626
Escherichia coli CFT073 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
XNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|670897.3.peg.172
Escherichia coli 2362-75 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VFT
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|216593.1.peg.3046
Escherichia coli E2348/69 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VFT
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|574521.7.peg.511
Escherichia coli O127:H6 str. E2348/69 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VFT
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|749547.3.peg.3540
Escherichia coli MS 187-1 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RSG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|749531.3.peg.3440
Escherichia coli MS 69-1 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
A
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
NSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VT
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
E
V
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|656444.3.peg.1047
Escherichia coli TA280 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTN
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|1040638.4.peg.5263
Escherichia coli O104:H4 str. LB226692 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
T
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|6666666.5357.peg.2328
Escherichia coli TY-2482 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
T
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|585055.6.peg.576
Escherichia coli 55989 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
T
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|585055.8.peg.577
Escherichia coli 55989 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
T
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|550676.3.peg.38
Escherichia coli B185 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
RPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
V
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|358709.5.peg.1979
Escherichia coli 101-1 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|670888.3.peg.1135
Escherichia coli 1827-70 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|344610.3.peg.1558
Escherichia coli 53638 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|344610.7.peg.1121
Escherichia coli 53638 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|481805.3.peg.3294
Escherichia coli ATCC 8739 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|481805.6.peg.3280
Escherichia coli ATCC 8739 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|413997.3.peg.563
Escherichia coli B str. REL606 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|550672.3.peg.142
Escherichia coli B088 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|511693.5.peg.558
Escherichia coli BL21 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|469008.4.peg.3196
Escherichia coli BL21(DE3) (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|595496.3.peg.496
Escherichia coli BW2952 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|536056.3.peg.3227
Escherichia coli DH1 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|340185.3.peg.1764
Escherichia coli E22 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|340185.4.peg.1859
Escherichia coli E22 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|331112.3.peg.579
Escherichia coli HS (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|331112.6.peg.606
Escherichia coli HS (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|585034.4.peg.550
Escherichia coli IAI1 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|585034.5.peg.549
Escherichia coli IAI1 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|83333.1.peg.573
Escherichia coli K12 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|749538.3.peg.2539
Escherichia coli MS 116-1 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|679205.4.peg.578
Escherichia coli MS 124-1 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|749544.3.peg.295
Escherichia coli MS 175-1 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|749548.3.peg.3348
Escherichia coli MS 196-1 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|749533.3.peg.5382
Escherichia coli MS 84-1 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|585395.4.peg.609
Escherichia coli O103:H2 str. 12009 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|316407.3.peg.556
Escherichia coli W3110 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|316385.5.peg.527
Escherichia coli str. K-12 substr. DH10B (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|316385.5.peg.638
Escherichia coli str. K-12 substr. DH10B (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|316385.7.peg.535
Escherichia coli str. K-12 substr. DH10B (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|316385.7.peg.646
Escherichia coli str. K-12 substr. DH10B (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|511145.12.peg.599
Escherichia coli str. K-12 substr. MG1655 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|511145.6.peg.590
Escherichia coli str. K-12 substr. MG1655 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DI
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
VPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|550677.3.peg.993
Escherichia coli B354 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|340184.3.peg.4467
Escherichia coli B7A (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|340184.6.peg.4678
Escherichia coli B7A (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|331111.12.peg.899
Escherichia coli E24377A (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|331111.3.peg.3124
Escherichia coli E24377A (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|562.375.peg.1588
Escherichia coli EC4100B (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|595495.4.peg.2045
Escherichia coli KO11 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|679204.3.peg.5117
Escherichia coli MS 145-7 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|749545.3.peg.4929
Escherichia coli MS 182-1 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|749532.3.peg.3646
Escherichia coli MS 78-1 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|409438.11.peg.764
Escherichia coli SE11 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|566546.3.peg.4930
Escherichia coli W (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|566546.4.peg.631
Escherichia coli W (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|562.371.peg.2826
Escherichia coli 1044A (379-1035/1045)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVIT
N
ASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LH
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|562.373.peg.3167
Escherichia coli 1125A (379-1035/1045)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVIT
N
ASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LH
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|562.372.peg.1557
Escherichia coli 1212A (379-1035/1045)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVIT
N
ASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LH
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|562.374.peg.5419
Escherichia coli 536A (379-1035/1045)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVIT
N
ASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LH
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|83334.1.peg.686
Escherichia coli O157:H7 (379-1035/1045)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVIT
N
ASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LH
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|155864.1.peg.608
Escherichia coli O157:H7 EDL933 (379-1035/1045)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVIT
N
ASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LH
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|155864.8.peg.623
Escherichia coli O157:H7 EDL933 (379-1035/1045)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVIT
N
ASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LH
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|444454.5.peg.5098
Escherichia coli O157:H7 str. EC4024 (379-1035/1045)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVIT
N
ASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LH
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|444449.5.peg.5434
Escherichia coli O157:H7 str. EC4042 (379-1035/1045)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVIT
N
ASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LH
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|444448.5.peg.3308
Escherichia coli O157:H7 str. EC4045 (379-1035/1045)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVIT
N
ASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LH
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|444453.5.peg.650
Escherichia coli O157:H7 str. EC4076 (379-1035/1045)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVIT
N
ASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LH
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|444452.5.peg.878
Escherichia coli O157:H7 str. EC4113 (379-1035/1045)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVIT
N
ASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LH
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|444450.8.peg.768
Escherichia coli O157:H7 str. EC4115 (379-1035/1045)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVIT
N
ASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LH
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|444451.5.peg.2270
Escherichia coli O157:H7 str. EC4196 (379-1035/1045)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVIT
N
ASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LH
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|444447.5.peg.3483
Escherichia coli O157:H7 str. EC4206 (379-1035/1045)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVIT
N
ASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LH
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|478004.5.peg.1476
Escherichia coli O157:H7 str. EC4401 (379-1035/1045)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVIT
N
ASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LH
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|478005.5.peg.3986
Escherichia coli O157:H7 str. EC4486 (379-1035/1045)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVIT
N
ASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LH
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|478006.5.peg.835
Escherichia coli O157:H7 str. EC4501 (379-1035/1045)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVIT
N
ASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LH
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|478007.5.peg.967
Escherichia coli O157:H7 str. EC508 (379-1035/1045)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVIT
N
ASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LH
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|478008.5.peg.1710
Escherichia coli O157:H7 str. EC869 (379-1035/1045)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVIT
N
ASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LH
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|637388.3.peg.1105
Escherichia coli O157:H7 str. FRIK2000 (379-1035/1045)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVIT
N
ASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LH
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|570506.3.peg.3642
Escherichia coli O157:H7 str. FRIK966 (379-1035/1045)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVIT
N
ASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LH
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|386585.9.peg.721
Escherichia coli O157:H7 str. Sakai (379-1035/1045)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVIT
N
ASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LH
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|544404.4.peg.633
Escherichia coli O157:H7 str. TW14359 (379-1035/1045)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVIT
N
ASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LH
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|502346.5.peg.588
Escherichia coli O157:H7 str. TW14588 (379-1035/1045)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVIT
N
ASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LH
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|405955.13.peg.550
Escherichia coli APEC O1 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
G
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|405955.9.peg.452
Escherichia coli APEC O1 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DTMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
G
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|656419.3.peg.850
Escherichia coli M718 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
I
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|656408.3.peg.504
Escherichia coli H591 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
TALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|679206.4.peg.4715
Escherichia coli MS 119-7 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
TALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QD
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|701177.3.peg.733
Escherichia coli O55:H7 str. CB9615 (381-1037/1047)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
Q
HQ
H
PD
ATL
DNKT
RWQVIT
N
ASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
AM
AG
A
A
L
L
A
I
V
VI
P
I
L
M
G
YW
I
RGKI
P
P
E
-----
-
------SSNP
L
N
R
FLI
R
V
---
Y
HPL
L
L
KVLH
WPKTTLL
V
AALS
V
LTV
L
W
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
GIS
A
A
EAASML
Q
KTD
K
--
L
I
MSV
P
E
V
AR
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
QE
QW
RPG
-
M
T
MDK
II
E
E
L
DNTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
LA
DI
DAMAE
Q
I
EEV
A
RTV
P
G
V
A
S
A
LA
E
R
L
E
G
G
RYIN
V
EI
N
R
EK
A
A
G
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
L
R
YPQSW
R
DSPQ
AL
RQLP
I
L
T
PM
K
QQ
I
T
L
A
DV
A
DV
K
VST
GP
SM
L
KTENARPTSW
I
YI
D
ARD--
-
-R
D
M
VSV
V
HDLQ
K
A
I
AE
K
VQLK---P
GT
S
VA
F
S
GQF
ELLER
ANHKLKL
M
VPM
T
L
MI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
V
P
F
A
L
VG
GIWL
L
WWM
G
FHL
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
EPSL
NNPQTFSE
QK
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|6666666.5357.peg.3438
Escherichia coli TY-2482 (381-1037/1048)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
D
HQ
H
PG
EQ
I
DNAT
RW
K
VITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
S
M
AG
A
A
A
L
A
I
I
VI
P
I
L
M
G
FW
I
RGKI
P
A
E
-----
-
------TSNP
L
N
R
VLI
K
A
---
Y
HPL
L
L
R
VLH
WPKTTLL
V
AALS
I
FTV
I
W
P
LSQ
V
G
GE
FLP
KI
N
E
G
DLLYMP
S
TLP
G
V
S
P
A
EAAALL
Q
TTD
K
--
L
I
KSV
P
E
V
AS
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
ED
QW
RPG
-
M
T
IDK
II
E
E
L
DRTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
L
S
DI
DATAQ
S
I
EAV
A
KTV
P
G
V
V
S
A
LA
E
R
L
E
G
G
RYID
V
DI
N
R
EK
A
S
R
Y
G
M
T
V
G
D
VQLF
I
S
S
A
I
G
GAT
V
GETVEGVAR
Y
P
I
N
I
R
YPQDY
R
NSPQ
AL
KQMP
I
L
T
PM
K
QQ
I
T
L
G
DV
A
DI
K
VVS
GP
TM
L
KTENARPASW
I
YI
D
ARG--
-
-R
D
M
VSV
V
NDIK
T
A
I
SQ
K
VKLR---P
GT
S
VS
F
S
GQF
ELLE
H
ANKKLKL
M
VPM
T
V
MI
I
FI
L
L
YL
AFRR
VDE
A
LL
IL
M
S
LP
F
A
L
VG
GIW
F
L
YWQ
G
FHM
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
HPEL
SRKE
TF
TP
EG
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|585055.6.peg.3944
Escherichia coli 55989 (381-1037/1048)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
D
HQ
H
PG
EQ
I
DNAT
RW
K
VITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
S
M
AG
A
A
A
L
A
I
I
VI
P
I
L
M
G
FW
I
RGKI
P
A
E
-----
-
------TSNP
L
N
R
VLI
K
A
---
Y
HPL
L
L
R
VLH
WPKTTLL
V
AALS
I
FTV
I
W
P
LSQ
V
G
GE
FLP
KI
N
E
G
DLLYMP
S
TLP
G
V
S
P
A
EAAALL
Q
TTD
K
--
L
I
KSV
P
E
V
AS
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
ED
QW
RPG
-
M
T
IDK
II
E
E
L
DRTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
L
S
DI
DATAQ
S
I
EAV
A
KTV
P
G
V
V
S
A
LA
E
R
L
E
G
G
RYID
V
DI
N
R
EK
A
S
R
Y
G
M
T
V
G
D
VQLF
I
S
S
A
I
G
GAT
V
GETVEGVAR
Y
P
I
N
I
R
YPQDY
R
NSPQ
AL
KQMP
I
L
T
PM
K
QQ
I
T
L
G
DV
A
DI
K
VVS
GP
TM
L
KTENARPASW
I
YI
D
ARG--
-
-R
D
M
VSV
V
NDIK
T
A
I
SQ
K
VKLR---P
GT
S
VS
F
S
GQF
ELLE
H
ANKKLKL
M
VPM
T
V
MI
I
FI
L
L
YL
AFRR
VDE
A
LL
IL
M
S
LP
F
A
L
VG
GIW
F
L
YWQ
G
FHM
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
HPEL
SRKE
TF
TP
EG
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|585055.8.peg.3946
Escherichia coli 55989 (381-1037/1048)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
D
HQ
H
PG
EQ
I
DNAT
RW
K
VITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
S
M
AG
A
A
A
L
A
I
I
VI
P
I
L
M
G
FW
I
RGKI
P
A
E
-----
-
------TSNP
L
N
R
VLI
K
A
---
Y
HPL
L
L
R
VLH
WPKTTLL
V
AALS
I
FTV
I
W
P
LSQ
V
G
GE
FLP
KI
N
E
G
DLLYMP
S
TLP
G
V
S
P
A
EAAALL
Q
TTD
K
--
L
I
KSV
P
E
V
AS
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
ED
QW
RPG
-
M
T
IDK
II
E
E
L
DRTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
L
S
DI
DATAQ
S
I
EAV
A
KTV
P
G
V
V
S
A
LA
E
R
L
E
G
G
RYID
V
DI
N
R
EK
A
S
R
Y
G
M
T
V
G
D
VQLF
I
S
S
A
I
G
GAT
V
GETVEGVAR
Y
P
I
N
I
R
YPQDY
R
NSPQ
AL
KQMP
I
L
T
PM
K
QQ
I
T
L
G
DV
A
DI
K
VVS
GP
TM
L
KTENARPASW
I
YI
D
ARG--
-
-R
D
M
VSV
V
NDIK
T
A
I
SQ
K
VKLR---P
GT
S
VS
F
S
GQF
ELLE
H
ANKKLKL
M
VPM
T
V
MI
I
FI
L
L
YL
AFRR
VDE
A
LL
IL
M
S
LP
F
A
L
VG
GIW
F
L
YWQ
G
FHM
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
HPEL
SRKE
TF
TP
EG
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|405955.13.peg.5316
Escherichia coli APEC O1 (381-1037/1048)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
D
HQ
H
PG
EQ
I
DNAT
RW
K
VITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
S
M
AG
A
A
A
L
A
I
I
VI
P
I
L
M
G
FW
I
RGKI
P
A
E
-----
-
------TSNP
L
N
R
VLI
K
A
---
Y
HPL
L
L
R
VLH
WPKTTLL
V
AALS
I
FTV
I
W
P
LSQ
V
G
GE
FLP
KI
N
E
G
DLLYMP
S
TLP
G
V
S
P
A
EAAALL
Q
TTD
K
--
L
I
KSV
P
E
V
AS
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
ED
QW
RPG
-
M
T
IDK
II
E
E
L
DRTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
L
S
DI
DATAQ
S
I
EAV
A
KTV
P
G
V
V
S
A
LA
E
R
L
E
G
G
RYID
V
DI
N
R
EK
A
S
R
Y
G
M
T
V
G
D
VQLF
I
S
S
A
I
G
GAT
V
GETVEGVAR
Y
P
I
N
I
R
YPQDY
R
NSPQ
AL
KQMP
I
L
T
PM
K
QQ
I
T
L
G
DV
A
DI
K
VVS
GP
TM
L
KTENARPASW
I
YI
D
ARG--
-
-R
D
M
VSV
V
NDIK
T
A
I
SQ
K
VKLR---P
GT
S
VS
F
S
GQF
ELLE
H
ANKKLKL
M
VPM
T
V
MI
I
FI
L
L
YL
AFRR
VDE
A
LL
IL
M
S
LP
F
A
L
VG
GIW
F
L
YWQ
G
FHM
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
HPEL
SRKE
TF
TP
EG
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|405955.9.peg.4433
Escherichia coli APEC O1 (381-1037/1048)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
D
HQ
H
PG
EQ
I
DNAT
RW
K
VITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
S
M
AG
A
A
A
L
A
I
I
VI
P
I
L
M
G
FW
I
RGKI
P
A
E
-----
-
------TSNP
L
N
R
VLI
K
A
---
Y
HPL
L
L
R
VLH
WPKTTLL
V
AALS
I
FTV
I
W
P
LSQ
V
G
GE
FLP
KI
N
E
G
DLLYMP
S
TLP
G
V
S
P
A
EAAALL
Q
TTD
K
--
L
I
KSV
P
E
V
AS
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
ED
QW
RPG
-
M
T
IDK
II
E
E
L
DRTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
L
S
DI
DATAQ
S
I
EAV
A
KTV
P
G
V
V
S
A
LA
E
R
L
E
G
G
RYID
V
DI
N
R
EK
A
S
R
Y
G
M
T
V
G
D
VQLF
I
S
S
A
I
G
GAT
V
GETVEGVAR
Y
P
I
N
I
R
YPQDY
R
NSPQ
AL
KQMP
I
L
T
PM
K
QQ
I
T
L
G
DV
A
DI
K
VVS
GP
TM
L
KTENARPASW
I
YI
D
ARG--
-
-R
D
M
VSV
V
NDIK
T
A
I
SQ
K
VKLR---P
GT
S
VS
F
S
GQF
ELLE
H
ANKKLKL
M
VPM
T
V
MI
I
FI
L
L
YL
AFRR
VDE
A
LL
IL
M
S
LP
F
A
L
VG
GIW
F
L
YWQ
G
FHM
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
HPEL
SRKE
TF
TP
EG
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|481805.3.peg.3679
Escherichia coli ATCC 8739 (381-1037/1048)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
D
HQ
H
PG
EQ
I
DNAT
RW
K
VITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
S
M
AG
A
A
A
L
A
I
I
VI
P
I
L
M
G
FW
I
RGKI
P
A
E
-----
-
------TSNP
L
N
R
VLI
K
A
---
Y
HPL
L
L
R
VLH
WPKTTLL
V
AALS
I
FTV
I
W
P
LSQ
V
G
GE
FLP
KI
N
E
G
DLLYMP
S
TLP
G
V
S
P
A
EAAALL
Q
TTD
K
--
L
I
KSV
P
E
V
AS
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
ED
QW
RPG
-
M
T
IDK
II
E
E
L
DRTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
L
S
DI
DVTAQ
S
I
EAV
A
KTV
P
G
V
V
S
A
LA
E
R
L
E
G
G
RYID
V
DI
N
R
EK
A
S
R
Y
G
M
T
V
G
D
VQLF
V
S
S
A
I
G
GAM
V
GETVEGVAR
Y
P
I
N
I
R
YPQDY
R
NSPQ
AL
REMP
I
L
T
PM
K
QQ
I
T
L
G
DV
A
DI
K
VVS
GP
TM
L
KTENARPASW
I
YV
D
ARG--
-
-R
D
M
VSV
V
NDIK
T
A
I
SE
K
VKLR---P
GT
S
VA
F
S
GQF
ELLE
H
ANKKLKL
M
VPM
T
V
MI
I
FI
L
L
YL
AFRR
VDE
A
LL
IL
M
S
LP
F
A
L
VG
GIW
F
L
YWQ
G
FHM
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
HPEL
SRKE
TF
TP
EG
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|481805.6.peg.3657
Escherichia coli ATCC 8739 (381-1037/1048)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
D
HQ
H
PG
EQ
I
DNAT
RW
K
VITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
S
M
AG
A
A
A
L
A
I
I
VI
P
I
L
M
G
FW
I
RGKI
P
A
E
-----
-
------TSNP
L
N
R
VLI
K
A
---
Y
HPL
L
L
R
VLH
WPKTTLL
V
AALS
I
FTV
I
W
P
LSQ
V
G
GE
FLP
KI
N
E
G
DLLYMP
S
TLP
G
V
S
P
A
EAAALL
Q
TTD
K
--
L
I
KSV
P
E
V
AS
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
ED
QW
RPG
-
M
T
IDK
II
E
E
L
DRTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
L
S
DI
DVTAQ
S
I
EAV
A
KTV
P
G
V
V
S
A
LA
E
R
L
E
G
G
RYID
V
DI
N
R
EK
A
S
R
Y
G
M
T
V
G
D
VQLF
V
S
S
A
I
G
GAM
V
GETVEGVAR
Y
P
I
N
I
R
YPQDY
R
NSPQ
AL
REMP
I
L
T
PM
K
QQ
I
T
L
G
DV
A
DI
K
VVS
GP
TM
L
KTENARPASW
I
YV
D
ARG--
-
-R
D
M
VSV
V
NDIK
T
A
I
SE
K
VKLR---P
GT
S
VA
F
S
GQF
ELLE
H
ANKKLKL
M
VPM
T
V
MI
I
FI
L
L
YL
AFRR
VDE
A
LL
IL
M
S
LP
F
A
L
VG
GIW
F
L
YWQ
G
FHM
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
HPEL
SRKE
TF
TP
EG
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|316401.4.peg.250
Escherichia coli ETEC H10407 (381-1037/1048)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
D
HQ
H
PG
EQ
I
DNAT
RW
K
VITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
S
M
AG
A
A
A
L
A
I
I
VI
P
I
L
M
G
FW
I
RGKI
P
A
E
-----
-
------TSNP
L
N
R
VLI
K
A
---
Y
HPL
L
L
R
VLH
WPKTTLL
V
AALS
I
FTV
I
W
P
LSQ
V
G
GE
FLP
KI
N
E
G
DLLYMP
S
TLP
G
V
S
P
A
EAAALL
Q
TTD
K
--
L
I
KSV
P
E
V
AS
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
ED
QW
RPG
-
M
T
IDK
II
E
E
L
DRTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
L
S
DI
DVTAQ
S
I
EAV
A
KTV
P
G
V
V
S
A
LA
E
R
L
E
G
G
RYID
V
DI
N
R
EK
A
S
R
Y
G
M
T
V
G
D
VQLF
V
S
S
A
I
G
GAM
V
GETVEGVAR
Y
P
I
N
I
R
YPQDY
R
NSPQ
AL
REMP
I
L
T
PM
K
QQ
I
T
L
G
DV
A
DI
K
VVS
GP
TM
L
KTENARPASW
I
YV
D
ARG--
-
-R
D
M
VSV
V
NDIK
T
A
I
SE
K
VKLR---P
GT
S
VA
F
S
GQF
ELLE
H
ANKKLKL
M
VPM
T
V
MI
I
FI
L
L
YL
AFRR
VDE
A
LL
IL
M
S
LP
F
A
L
VG
GIW
F
L
YWQ
G
FHM
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
HPEL
SRKE
TF
TP
EG
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
fig|749537.3.peg.100
Escherichia coli MS 115-1 (381-1037/1048)
M
H
F
Q
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
IEN
AH
K
R
L
E
E
W
D
HQ
H
PG
EQ
I
DNAT
RW
K
VITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTL
E
G
QE
GRL
F
G
P
L
A
F
T
KTY
S
M
AG
A
A
A
L
A
I
I
VI
P
I
L
M
G
FW
I
RGKI
P
A
E
-----
-
------TSNP
L
N
R
VLI
K
A
---
Y
HPL
L
L
R
VLH
WPKTTLL
V
AALS
I
FTV
I
W
P
LSQ
V
G
GE
FLP
KI
N
E
G
DLLYMP
S
TLP
G
V
S
P
A
EAAALL
Q
TTD
K
--
L
I
KSV
P
E
V
AS
VF
GK
TG
KAETATDS
A
PLE
M
V
ETT
I
Q
LKP
ED
QW
RPG
-
M
T
IDK
II
E
E
L
DRTVRLPGL
A
N
L
WVP
P
IRN-R
I
DMLS
T
GIKSPIG
I
KV
-
S
G
TV
L
S
DI
DVTAQ
S
I
EAV
A
KTV
P
G
V
V
S
A
LA
E
R
L
E
G
G
RYID
V
DI
N
R
EK
A
S
R
Y
G
M
T
V
G
D
VQLF
V
S
S
A
I
G
GAM
V
GETVEGVAR
Y
P
I
N
I
R
YPQDY
R
NSPQ
AL
REMP
I
L
T
PM
K
QQ
I
T
L
G
DV
A
DI
K
VVS
GP
TM
L
KTENARPASW
I
YV
D
ARG--
-
-R
D
M
VSV
V
NDIK
T
A
I
SE
K
VKLR---P
GT
S
VA
F
S
GQF
ELLE
H
ANKKLKL
M
VPM
T
V
MI
I
FI
L
L
YL
AFRR
VDE
A
LL
IL
M
S
LP
F
A
L
VG
GIW
F
L
YWQ
G
FHM
S
V
ATGT
G
F
I
A
L
A
G
V
A
A
EFGV
V
M
L
M
YLRH
A
I
EA
HPEL
SRKE
TF
TP
EG
L
D
EA
LY
H
GA
V
LR
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TG
A
GSE
VMSR
I
A
AP
M
I
GGMI
T
A
P
LL
S
LF
II
P
AA
Y
K
L
Consen1
Primary consensus
M
f
g
s
N
ltl
al
iA
G
vVDdAIVviEN
r
l
E
g
p
Atl
----------
eig
al
l
avfiPl
gg
Grl
r
fa
T
Am
s
lval
ltP
lcg
l
p
k
-----
q
f
R
a
---
Y
l
kvLh
v
l
v
l
ip
FlP
d
G
q
gis
a
q
k
--
i
p
v
vf
tG
n
m
---
I
LKp
er
-
t
iI
rl
a
l
a
i
s
l
-
g
laal
ql
a
P
la
v
d
ld
g
v
dr
a
rlGi
v
d
l
nA
G
v
y
v
le
r
al
v
n
g
ipls
A
r
gp
l
I
n
s
da
i
k
l
p
gta
fq
-----
l
al
vfi
L
lyes
p
ils
lP
a
vGallal
g
dv
G
i
liGi
aknaimmv
f
---
A
ea
g
-------
l
eA
hac
lR
RPi
MT
la
i
G
LPl
stG
Gse
lg
mvGGmi
a
lLtlf
P
y
lfdRLaLw
-
ksRFaRheeeA
Consen2
Secondary consensus
l
d
n
msm
g
l
a
m
k
q
h
ar
rwqvitdasvqvq
t
i
lsl
ed
ai
g
ls
i
a
vls
vi
mma
i
l
egehhg
-
l
r
qqg
v
wi
n
i
p
g
f
n
s
sst
q
dyy
t
d
i
lt
v
a
l
ett
d
qw
t
r
v
ea
v
v
p
v
i
h
-
hddi
ki
l
v
a
qe
s
nq
m
ay
a
v
i
k
i
t
di
k
vtfa
as
-
tm
t
i
k
ws
ys
eller
m
y
afrr
a
v
l
v
g
i
giwlt
n
sl
va
kefgv
i
ylrh
am
nnpqtfse
p
d
qga
q
k
av
l
gg
ag
a
lv
s
iy
f
fvr
r
-
t
--
s
kpkq
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character