┌─ Escherichia coli (3-288/297) 83972 (12)  
                                                     ┌┴─ Escherichia coli (3-288/297) ED1a (1)  
                                                    ┌┴─ Escherichia coli (3-288/297) 2362-75 (10)  
                                                   ┌┴─ Escherichia coli (3-288/297) E2348/69 (1)  
                                                  ┌┴─ Escherichia coli (3-288/297) FVEC1302 (5)  
                                                 ┌┴─ Escherichia coli (3-288/297) O83:H1 str. NRG 857C (1)  
                                                ┌┴─ Escherichia coli (3-288/297) MS 115-1   
                                               ┌┴┬─ Escherichia coli (3-288/297) SMS-3-5   
                                              ┌┤ └─ Escherichia coli (3-288/297) B354   
                                              │└┬─ Escherichia coli (3-288/297) 53638 (1)  
                                             ┌┤ └─ Escherichia coli (3-288/297) K12 (22)  
                                             │└┬─ Escherichia coli (3-288/297) 042 (50)  
                                             │ └┬─ Escherichia coli (3-288/297) EC4100B   
                                            ┌┤  └┬─ Escherichia coli (3-288/297) B171 (1)  
                                            ││   └─ Escherichia coli (3-288/297) E22 (2)  
                                           ┌┤└┬─ fig|1040638.4.peg.3641 O104:H4 (3-288/297) str. LB226692 (3)  
                                           ││ └─ Escherichia coli (3-288/297) KO11 (2)  
                            ┌──────────────┤└─ Escherichia coli (3-288/297) O111:H- str. 11128 (1)  
                            │              └─ Escherichia coli (3-288/297) MS 21-1   
                    ┌───────┤                     ┌── Escherichia coli (7-289/294) IAI39 (1)  
                    │       └─────────────────────┤    ┌─ Escherichia coli (8-283/294) 2362-75   
                    │                             │    │  ┌─ Escherichia coli (13-288/299) CFT073 (1)  
                    │                             └────┤ ┌┴─ Escherichia coli (8-283/294) 83972 (3)  
                    │                                  │┌┴─ Escherichia coli (8-283/294) 536 (4)  
                    │                                  └┤┌─ Escherichia coli (8-283/294) MS 21-1   
                    │                                   └┤┌─ Escherichia coli (8-283/294) APEC O1 (15)  
                    │                                    └┤  ┌─ Escherichia coli (8-294/294) TA143   
                ┌───┤                                     │ ┌┴─ Escherichia coli (8-283/294) B354   
                │   │                                     └┬┴─ Escherichia coli (8-283/294) H299   
                │   │                                      └┬─ Escherichia coli (8-294/294) K12 (15)  
                │   │                                       └┬─ Escherichia coli (8-294/294) H591 (7)  
                │   │                                        └┬─ Escherichia coli (8-294/294) TA271   
                │   │                                         └┬─ fig|1040638.4.peg.2817 O104:H4 (8-294/294) str. LB226692 (2)  
      ┌─────────┤   │                                          └─ Escherichia coli (8-294/294) E22 (2)  
      │         │   └───────────────────────┬─ Escherichia coli (1-293/295) B354   
      │         │                           └┬─ Escherichia coli (1-293/295) TA280   
      │         │                            └─ Escherichia coli (1-293/295) FVEC1302 (5)  
      │         │                   ┌─ Escherichia coli TA280   
      │         └───────────────────┤┌─ Escherichia coli 042 (5) [2] 
      │                             ││  ┌─ Escherichia coli (22-318/318) SMS-3-5   
      │                             └┤ ┌┴─ Escherichia coli IAI39 (2)  
      │                              │┌┴─ Escherichia coli H299 (1)  
      │                              └┤┌─ Escherichia coli B354   
      │                               ││  ┌─ Escherichia coli (22-318/318) str. K-12 substr. DH10B   
      │                               └┤ ┌┴─ Escherichia coli K12 (4)  
      │                                │┌┴─ Escherichia coli BW2952 (9)  
      │                                ││   ┌─ fig|6666666.5357.peg.2605 TY-2482 strain (26)  
      │                                └┤  ┌┴─ Escherichia coli (31-327/327) ATCC 8739 (1)  
   ┌──┤                                 │ ┌┴─ Escherichia coli B7A  [3] 
   │  │                                 └┬┴─ Escherichia coli B185   
   │  │                                  └┬─ fig|1040638.4.peg.2965 O104:H4 str. LB226692 (28)  
   │  │                                   └┬─ Escherichia coli MS 182-1 (2)  
   │  │                                    └┬─ Escherichia coli B171 (4)  
   │  │                                     └─ Escherichia coli (22-318/318) E22  [2] 
   │  │                                                            ┌─ Escherichia coli (14-287/301) FVEC1412 (2)  
   │  │                                                           ┌┴─ Escherichia coli (14-287/301) TA280   
   │  │                                                          ┌┴┬─ Escherichia coli (14-287/301) 042 (1)  
   │  │                                                         ┌┤ └─ Escherichia coli (14-287/301) B354 (6)  
   │  │                                                         │└┬─ Escherichia coli (14-287/301) 1044A (25)  
   │  │           ┌─────────────────────────────────────────────┤ └─ Escherichia coli (14-287/301) B185   
   │  │ ┌─────────┤                                             └─ Escherichia coli (14-287/301) M718   
   │  │ │         └──────────────────────────────────────────────┬─ Escherichia coli (1-296/298) B354   
   │  │ │                                                        └┬─ Escherichia coli (1-296/298) FVEC1302 (4)  
   │  └─┤                                                         └┬─ Escherichia coli (1-296/298) B185   
   │    │                                                          └─ Escherichia coli (1-296/298) MS 21-1   
   │    │                          ┌─ Escherichia coli (29-310/326) MS 146-1   
   │    │                         ┌┴─ Escherichia coli (1-282/301) H736   
   │    └─────────────────────────┤┌─ Escherichia coli (1-293/299) K12 (13)  
   │                              └┤┌─ Escherichia coli (1-293/299) B185 (1)  
   │                               └┤┌─ Escherichia coli (1-293/299) M718   
   │                                ││   ┌─ Escherichia coli (9-301/307) 042 (1)  
   │                                └┤  ┌┴─ Escherichia coli (9-301/307) FVEC1302 (3)  
┌──┤                                 │ ┌┴─ Escherichia coli (9-301/307) TA143   
│  │                                 │┌┴─ Escherichia coli (1-293/299) IAI39 (2)  
│  │                                 └┤┌─ Escherichia coli (1-293/299) ATCC 8739 (2)  
│  │                                  └┤┌─ Escherichia coli (1-293/299) MS 21-1   
│  │                                   └┤ ┌─ Escherichia coli (9-301/307) B088 (18)  
│  │                                    │┌┴─ Escherichia coli (1-293/299) B354   
│  │                                    └┤ ┌─ Escherichia coli (1-282/288) MS 78-1   
│  │                                     │┌┴─ Escherichia coli (1-293/299) TA280   
│  │                                     └┤ ┌─ Escherichia coli (1-293/299) H591 (4)  
│  │                                      └┬┴─ fig|1040638.4.peg.5351 O104:H4 (1-293/299) str. LB226692 (9)  
│  │                                       └┬─ Escherichia coli (1-293/299) 1044A (24)  
│  │                                        └─ Escherichia coli (1-293/299) O55:H7 str. CB9615   
│  │                                              ┌─ Escherichia coli (1-282/317) FVEC1302 (3)  
│  │                                             ┌┴─ Escherichia coli (1-282/317) B354   
│  │                                            ┌┴─ Escherichia coli (1-282/317) 042 (51)  
│  │                                           ┌┴─ Escherichia coli (1-282/317) K12 (56)  
│  │                                          ┌┴─ Escherichia coli (1-282/317) 83972 (12)  
│  │                   ┌──────────────────────┴─ Escherichia coli (1-282/317) M718   
│  │  ┌────────────────┴───────────────────────────────┬─ Escherichia coli (8-301/302) 1044A (25)  
│  │  │                                                └─ Escherichia coli (8-301/302) MS 21-1 (1)  
│  │  │                                                         ┌─ Escherichia coli (8-281/298) 101-1 (25)  
│  │  │                                                        ┌┴─ Escherichia coli (8-281/301) WV_060327   
│  │  │                                                       ┌┴─ Escherichia coli (8-281/301) ED1a (1)  
│  └──┤                                                      ┌┴┬─ Escherichia coli (8-281/301) NC101   
│     │                                                      │ └┬─ Escherichia coli (8-281/301) MS 69-1   
│     │                                                     ┌┤  └─ Escherichia coli (8-281/301) 2362-75 (2)  
│     │                          ┌──────────────────────────┤└─ Escherichia coli (8-281/301) APEC O1 (2)  
│     │                          │                          └─ Escherichia coli (8-281/301) F11 (1)  
│     │                          │                  ┌─ Escherichia coli (1-298/308) TA280   
│     └──────────────────────────┤                  │    ┌─ Escherichia coli (1-298/308) HS (1)  
│                                │                  │   ┌┴─ Escherichia coli (1-298/308) ETEC H10407   
│                                │                  │  ┌┴─ Escherichia coli (1-298/308) MS 119-7   
│                                └──────────────────┤ ┌┴─ Escherichia coli (1-298/308) SMS-3-5   
│                                                   │┌┴┬─ Escherichia coli (1-298/308) K12 (65)  
│                                                   ││ └─ Escherichia coli (7-298/308) ATCC 8739 (1)  
│                                                   ││   ┌─ fig|6666666.5357.peg.4889 TY-2482 (1-298/308) strain (11)  
│                                                   └┤  ┌┴─ Escherichia coli (1-298/308) E110019 (1)  
│                                                    │ ┌┴─ Escherichia coli (1-298/308) O103:H2 str. 12009   
│                                                    │┌┴┬─ Escherichia coli (1-298/308) B185   
│                                                    └┤ └─ Escherichia coli (1-298/308) FVEC1302 (3)  
│                                                     └┬─ Escherichia coli (1-298/308) NC101 (1)  
┤                                                      └┬─ Escherichia coli (1-298/308) H299   
│                                                       └┬─ Escherichia coli (1-298/308) O83:H1 str. NRG 857C (1)  
│                                                        └┬─ Escherichia coli (1-298/308) APEC O1 (7)  
│                                                         └─ Escherichia coli (1-298/308) 2362-75 (16)  
│                                                                      ┌─ Escherichia coli (10-296/312) IAI1 (1)  
│                                                                     ┌┴─ Escherichia coli (10-296/312) MS 115-1   
│                                                                    ┌┴─ Escherichia coli (10-296/312) K12 (120)  
│                                                                   ┌┴┬─ Escherichia coli (10-296/312) B088   
│                                                                   │ └┬─ Escherichia coli (10-296/312) MS 116-1 (1)  
│                                                                  ┌┤  └─ Escherichia coli (10-296/312) O111:H- str. 11128   
│                                                                  │└┬─ Escherichia coli (10-296/312) B354   
│                                                                 ┌┤ └─ Escherichia coli (10-296/312) MS 21-1   
│                                              ┌──────────────────┤└─ Escherichia coli (10-296/312) M605 (1)  
│                               ┌──────────────┤                  └─ Escherichia coli (10-296/312) O26:H11 str. 11368   
│           ┌───────────────────┤              └───────────────────── Escherichia coli (13-301/309) 53638   
│           │                   └──────────────────────┬─ fig|6666666.5357.peg.1333 TY-2482 (5-285/302) strain (21)  
│           │                                          └┬─ Escherichia coli (5-285/302) B7A (2)  
│           │                                           └┬─ Escherichia coli (5-285/302) HS (1)  
│       ┌───┤                                            └┬─ Escherichia coli (5-285/302) M605   
│       │   │                                             └┬─ Escherichia coli (5-285/302) E110019 (1)  
│       │   │                                              └┬─ Escherichia coli (5-285/302) 101-1 (52)  
│       │   │                                               └─ Escherichia coli (5-285/302) K12 (7)  
│┌──────┤   └─────────────────────────────────── Escherichia coli (3-289/311) MS 119-7   
││      │                                ┌─ Escherichia coli (25-311/338) B171 (3) [2] 
││      │                                │ ┌─ Escherichia coli (1-283/310) B354   
││      └────────────────────────────────┤┌┴─ Escherichia coli (1-283/310) HS (1)  
││                                       ││   ┌─ Escherichia coli (4-290/317) SE15   
││                                       └┤  ┌┴─ Escherichia coli (1-283/310) M605   
││                                        │ ┌┴─ Escherichia coli (4-290/317) SMS-3-5   
││                                        │┌┴┬─ Escherichia coli (1-283/310) K12   
││                                        └┤ └─ Escherichia coli (4-290/317) BW2952 (6)  
││                                         │┌─ Escherichia coli (4-290/317) B185 (1)  
││                                         └┤ ┌─ Escherichia coli (4-290/317) E24377A (2)  
││                                          └┬┴─ Escherichia coli (25-311/338) 53638 (1)  
││                                           └┬─ Escherichia coli (4-290/317) MS 187-1   
││                                            └┬─ Escherichia coli (4-290/317) MS 115-1   
││                                             └┬─ fig|6666666.5357.peg.2190 TY-2482 (4-290/317) strain (92)  
││                                              └┬─ Escherichia coli (4-290/317) MS 21-1   
││                                               └─ Escherichia coli (4-290/317) IAI1 (1)  
││                                                ┌─ Escherichia coli (4-284/311) O157:H7 EDL933 (1)  
││                                               ┌┴─ Escherichia coli (4-284/311) 1044A (23)  
││                                              ┌┴─ Escherichia coli (4-284/311) E24377A (3)  
└┤                                             ┌┴─ Escherichia coli (4-284/311) K12 (9)  
 │                                            ┌┴─ fig|1040638.4.peg.2736 O104:H4 (4-284/311) str. LB226692 (42)  
 │                                           ┌┴┬─ Escherichia coli (4-284/311) H736 (1)  
 │                                          ┌┤ └─ Escherichia coli (4-284/311) MS 182-1 (1)  
 │                                         ┌┤└─ Escherichia coli (4-292/311) B354   
 │                                        ┌┤└─ Escherichia coli (4-284/311) WV_060327   
 │                                       ┌┤└─ Escherichia coli (4-284/311) 2362-75 (18)  
 │                                      ┌┤└─ Escherichia coli (4-284/311) 83972 (11)  
 │   ┌──────────────────────────────────┤└─ Escherichia coli (4-284/311) MS 185-1   
 │   │                                  └┬─ Escherichia coli (4-284/311) FVEC1302 (5)  
 │   │                                   └┬─ Escherichia coli (4-284/311) MS 69-1   
 │   │                                    └─ Escherichia coli (4-284/311) 042 (1)  
 │   │                                     ┌─ Escherichia coli (1-282/293) E2348/69 (1)  
 │   │                                    ┌┴─ Escherichia coli (1-282/293) 2362-75   
 │   │                                   ┌┴─ Escherichia coli (1-282/293) WV_060327   
 │   │                                  ┌┴─ Escherichia coli (1-282/293) 536 (22)  
 │   │                                 ┌┴┬─ Escherichia coli (1-282/293) ETEC H10407   
 │   │                                 │ └┬─ Escherichia coli (1-283/293) 1827-70 (4)  
 │   │                                 │  └─ Escherichia coli (1-282/293) K12 (18)  
 │   │                                ┌┤ ┌─ Escherichia coli (1-282/291) 042 (1)  
 └───┤                                ││┌┴─ Escherichia coli (1-282/293) SE15   
     │                                │└┤ ┌─ Escherichia coli (1-282/293) MS 21-1   
     │                               ┌┤ └┬┴─ Escherichia coli (1-282/291) FVEC1302 (3)  
     │                               ││  └┬─ Escherichia coli (1-282/293) SMS-3-5   
     │                              ┌┤│   └─ Escherichia coli (1-282/293) B354 (4)  
     │                              ││└─ Escherichia coli (1-282/291) H299   
     │                              │└─ Escherichia coli (1-282/293) 53638 (1)  
     │   ┌──────────────────────────┤ ┌─ Escherichia coli (1-282/293) EC4100B   
     │   │                          │┌┴─ fig|1040638.4.peg.4278 O104:H4 (1-282/293) str. LB226692 (12)  
     │   │                          └┤ ┌─ Escherichia coli (1-282/293) B171 (16)  
     │   │                           └┬┴─ Escherichia coli (1-282/293) B7A (2)  
     │   │                            └┬─ Escherichia coli (1-282/293) B185   
     └───┤                             └┬─ Escherichia coli (1-282/293) M718   
         │                              └┬─ Escherichia coli (1-282/293) O157:H7 EDL933 (1)  
         │                               └─ Escherichia coli (1-282/293) 1044A (23)  
         │                                      ┌─ Escherichia coli (1-292/293) O26:H11 str. 11368   
         │                                      │┌─ Escherichia coli (15-307/308) B088   
         └──────────────────────────────────────┤│   ┌─ Escherichia coli (1-288/293) M718   
                                                ││  ┌┴─ Escherichia coli (1-288/293) O157:H7 (1)  
                                                └┤ ┌┴─ Escherichia coli (15-303/308) 1044A (23)  
                                                 │┌┴─ Escherichia coli (1-288/293) B185   
                                                 ││   ┌─ Escherichia coli (1-292/293) ETEC H10407   
                                                 ││  ┌┴─ Escherichia coli (1-288/293) MS 115-1   
                                                 └┤ ┌┴─ Escherichia coli (15-307/308) B171 (2)  
                                                  │┌┴─ Escherichia coli (1-292/293) B171 (12)  
                                                  ││ ┌─ fig|1040638.4.peg.3008 O104:H4 (1-292/293) str. LB226692 (3)  
                                                  └┤┌┴─ Escherichia coli (15-303/308) B7A (1) [2] 
                                                   ││ ┌─ Escherichia coli (1-288/293) FVEC1302 (3)  
                                                   ││┌┴─ Escherichia coli (15-303/308) 042  [2] 
                                                   └┤│     ┌─ Escherichia coli (1-288/293) B354   
                                                    ││    ┌┴─ Escherichia coli (1-288/293) TA280   
                                                    ││   ┌┴─ Escherichia coli (1-288/293) MS 69-1   
                                                    └┤  ┌┴─ Escherichia coli (1-288/293) TA143   
                                                     │ ┌┴┬─ Escherichia coli (1-288/293) MS 21-1   
                                                     │┌┤ └─ Escherichia coli (1-288/293) SMS-3-5   
                                                     ││└─ Escherichia coli (15-307/308) EC4100B   
                                                     └┤ ┌─ Escherichia coli (15-307/308) 53638 (3)  
                                                      │┌┴─ Escherichia coli (1-292/293) K12 (20)  
                                                      └┤ ┌─ Escherichia coli (1-288/293) H299 (3)  
                                                       │┌┴─ Escherichia coli (1-288/293) ED1a (1)  
                                                       └┤┌─ Escherichia coli (1-288/293) NC101   
                                                        └┤ ┌─ Escherichia coli (15-303/308) E2348/69 (1)  
                                                         └┬┴─ Escherichia coli (1-288/293) 2362-75   
                                                          └┬─ Escherichia coli (15-303/308) CFT073 (1)  
                                                           └┬─ Escherichia coli (1-288/293) 536 (10)  
                                                            └─ Escherichia coli (15-303/308) APEC O1  [2] 
  
LysR family transcriptional regulator YfiE (30)
LysR family transcriptional regulator YneJ (22)
LysR family transcriptional regulator YnfL (21)
Cyn operon transcriptional activator (18)
LysR family transcriptional regulator YbhD (15)
Hca operon (3-phenylpropionic acid catabolism) transcriptional activator HcaR (15)
DNA-binding transcriptional activator of the allD operon (15)
Xanthosine operon regulatory protein XapR, LysR family (14)
Transcriptional activator protein LysR (14)
Threonine catabolic operon transcriptional activator TdcA (10)
Hypothetical lysR-family transcriptional regulator YdhB (8)
Putative LysR-like transcriptional regulator (7)
Regulatory protein (induces abgABT, used to catabolize p-aminobenzoyl-glutamate) (6)
Transcriptional activator MetR (6)
hypothetical protein (4)
Putative transcriptional regulator (2)
Hypothetical lysR-family transcriptional regulator YbbS (1)
Transcriptional regulator, LysR family (1)
HTH-type transcriptional regulator tdcA (1)
Others (11)