fig|1040638.4.peg.2882
Escherichia coli O104:H4 str. LB226692
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|6666666.5357.peg.4416
Escherichia coli TY-2482 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|670897.3.peg.3434
Escherichia coli 2362-75 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|585055.6.peg.2782
Escherichia coli 55989 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|585055.8.peg.2786
Escherichia coli 55989 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|405955.13.peg.2715
Escherichia coli APEC O1 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|405955.9.peg.2235
Escherichia coli APEC O1 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|550676.3.peg.1663
Escherichia coli B185 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|550677.3.peg.2332
Escherichia coli B354 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|340185.3.peg.3122
Escherichia coli E22 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|340185.4.peg.3285
Escherichia coli E22 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|585034.4.peg.2485
Escherichia coli IAI1 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|585034.5.peg.2483
Escherichia coli IAI1 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|585057.4.peg.2710
Escherichia coli IAI39 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|585057.6.peg.2713
Escherichia coli IAI39 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|714962.3.peg.2822
Escherichia coli IHE3034 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|656417.3.peg.3145
Escherichia coli M605 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|656419.3.peg.3228
Escherichia coli M718 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|749550.3.peg.5137
Escherichia coli MS 200-1 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|753642.3.peg.2636
Escherichia coli NC101 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|585395.4.peg.3117
Escherichia coli O103:H2 str. 12009 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|585035.6.peg.2620
Escherichia coli S88 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|431946.3.peg.2428
Escherichia coli SE15 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|656437.3.peg.2792
Escherichia coli TA143 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|869729.3.peg.928
Escherichia coli UM146 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|364106.7.peg.2801
Escherichia coli UTI89 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|364106.8.peg.2801
Escherichia coli UTI89 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|562.376.peg.4385
Escherichia coli WV_060327 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|585397.7.peg.2914
Escherichia coli ED1a (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNSER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|585397.9.peg.2911
Escherichia coli ED1a (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNSER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|685038.3.peg.2506
Escherichia coli O83:H1 str. NRG 857C (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNSER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|749527.3.peg.4775
Escherichia coli MS 21-1 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AQL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|562.371.peg.5329
Escherichia coli 1044A (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|562.373.peg.3655
Escherichia coli 1125A (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|562.372.peg.1878
Escherichia coli 1212A (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|562.374.peg.3080
Escherichia coli 536A (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|481805.3.peg.1293
Escherichia coli ATCC 8739 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|481805.6.peg.1292
Escherichia coli ATCC 8739 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|413997.3.peg.2471
Escherichia coli B str. REL606 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|511693.5.peg.2483
Escherichia coli BL21 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|469008.4.peg.1253
Escherichia coli BL21(DE3) (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|595496.3.peg.2446
Escherichia coli BW2952 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|536056.3.peg.1263
Escherichia coli DH1 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|316401.4.peg.2937
Escherichia coli ETEC H10407 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|656414.3.peg.2834
Escherichia coli H736 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|83333.1.peg.2438
Escherichia coli K12 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|749538.3.peg.4763
Escherichia coli MS 116-1 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|749540.3.peg.1070
Escherichia coli MS 146-1 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|749544.3.peg.2847
Escherichia coli MS 175-1 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|749547.3.peg.2320
Escherichia coli MS 187-1 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|585396.4.peg.3291
Escherichia coli O111:H- str. 11128 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|83334.1.peg.3329
Escherichia coli O157:H7 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|155864.1.peg.3330
Escherichia coli O157:H7 EDL933 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|444454.5.peg.2351
Escherichia coli O157:H7 str. EC4024 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|444449.5.peg.1816
Escherichia coli O157:H7 str. EC4042 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|444448.5.peg.570
Escherichia coli O157:H7 str. EC4045 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|444453.5.peg.52
Escherichia coli O157:H7 str. EC4076 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|444452.5.peg.1540
Escherichia coli O157:H7 str. EC4113 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|444450.8.peg.3659
Escherichia coli O157:H7 str. EC4115 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|444451.5.peg.1310
Escherichia coli O157:H7 str. EC4196 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|444447.5.peg.710
Escherichia coli O157:H7 str. EC4206 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|478004.5.peg.2971
Escherichia coli O157:H7 str. EC4401 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|478005.5.peg.2541
Escherichia coli O157:H7 str. EC4486 (210-977/977)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|478006.5.peg.1579
Escherichia coli O157:H7 str. EC4501 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|478007.5.peg.1624
Escherichia coli O157:H7 str. EC508 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|478008.5.peg.3015
Escherichia coli O157:H7 str. EC869 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|637388.3.peg.131
Escherichia coli O157:H7 str. FRIK2000 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|570506.3.peg.5202
Escherichia coli O157:H7 str. FRIK966 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|386585.9.peg.3479
Escherichia coli O157:H7 str. Sakai (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|544404.4.peg.3462
Escherichia coli O157:H7 str. TW14359 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|502346.5.peg.3954
Escherichia coli O157:H7 str. TW14588 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|573235.3.peg.3579
Escherichia coli O26:H11 str. 11368 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|701177.3.peg.3023
Escherichia coli O55:H7 str. CB9615 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|316407.3.peg.2391
Escherichia coli W3110 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|316385.5.peg.2600
Escherichia coli str. K-12 substr. DH10B (210-977/977)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|316385.7.peg.2658
Escherichia coli str. K-12 substr. DH10B (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|511145.12.peg.2564
Escherichia coli str. K-12 substr. MG1655 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|511145.6.peg.2550
Escherichia coli str. K-12 substr. MG1655 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|340186.3.peg.1585
Escherichia coli E110019 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DD
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|340186.5.peg.1634
Escherichia coli E110019 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DD
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|670888.3.peg.3828
Escherichia coli 1827-70 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-K
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|656379.3.peg.3043
Escherichia coli FVEC1302 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHE
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|656380.3.peg.2543
Escherichia coli FVEC1412 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHE
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|749549.3.peg.1756
Escherichia coli MS 198-1 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHE
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|585056.7.peg.2966
Escherichia coli UMN026 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHE
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|749531.3.peg.2713
Escherichia coli MS 69-1 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
E
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|656393.3.peg.3483
Escherichia coli H299 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
M
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|550672.3.peg.2189
Escherichia coli B088 (142-909/909)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
D
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|340184.3.peg.2721
Escherichia coli B7A (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
D
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|340184.6.peg.2848
Escherichia coli B7A (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
D
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|562.375.peg.3443
Escherichia coli EC4100B (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
D
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|656408.3.peg.2751
Escherichia coli H591 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
D
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|595495.4.peg.2507
Escherichia coli KO11 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
D
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|679206.4.peg.651
Escherichia coli MS 119-7 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
D
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|749532.3.peg.3273
Escherichia coli MS 78-1 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
D
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|409438.11.peg.2918
Escherichia coli SE11 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
D
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|566546.3.peg.2692
Escherichia coli W (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
D
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|566546.4.peg.2662
Escherichia coli W (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
D
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|340197.3.peg.3049
Escherichia coli F11 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QHK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|340197.5.peg.3187
Escherichia coli F11 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QHK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|439855.10.peg.2775
Escherichia coli SMS-3-5 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
M
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|216592.1.peg.5437
Escherichia coli 042 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SI
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
V
S
FA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|216592.3.peg.2793
Escherichia coli 042 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SI
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
V
S
FA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|525281.3.peg.4252
Escherichia coli 83972 (210-977/977)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
TFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNSER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|655817.3.peg.2900
Escherichia coli ABU 83972 (210-977/977)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
TFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNSER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|199310.1.peg.2922
Escherichia coli CFT073 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
TFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNSER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|199310.4.peg.2827
Escherichia coli CFT073 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
TFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNSER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|749528.3.peg.2359
Escherichia coli MS 45-1 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
TFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNSER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|679207.4.peg.2750
Escherichia coli MS 107-1 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATI
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
D
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|216593.1.peg.2195
Escherichia coli E2348/69 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GLHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|574521.7.peg.2753
Escherichia coli O127:H6 str. E2348/69 (142-909/909)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GLHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|155864.8.peg.3235
Escherichia coli O157:H7 EDL933 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTXKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|362663.8.peg.2511
Escherichia coli 536 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IIA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
V
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|362663.9.peg.2516
Escherichia coli 536 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IIA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
V
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|358709.5.peg.2250
Escherichia coli 101-1 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQPLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|679205.4.peg.1336
Escherichia coli MS 124-1 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVT
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
D
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|749533.3.peg.1535
Escherichia coli MS 84-1 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVT
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
D
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|679204.3.peg.1632
Escherichia coli MS 145-7 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LVL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
D
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|331111.12.peg.3018
Escherichia coli E24377A (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
E
QRK
A
Q
A
L
GV
D
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|331111.3.peg.472
Escherichia coli E24377A (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
E
QRK
A
Q
A
L
GV
D
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|749548.3.peg.1997
Escherichia coli MS 196-1 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKGVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|749545.3.peg.420
Escherichia coli MS 182-1 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
PT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
D
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|331112.3.peg.2439
Escherichia coli HS (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
IT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
T
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|331112.6.peg.2543
Escherichia coli HS (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
IT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
T
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|749546.3.peg.459
Escherichia coli MS 185-1 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
TFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNSER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
RSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|344610.3.peg.415
Escherichia coli 53638 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
R
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
T
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|344610.7.peg.3865
Escherichia coli 53638 (270-1037/1037)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMVF
L
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNQIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
R
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
T
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|656444.3.peg.3458
Escherichia coli TA280 (270-1035/1035)
M
G
A
E
K
Y
DY
L
S
R
F
N
G
K
-
P
A
SGLG
V
KLAS
GAN
EMA
T
AEL
V
LNR
L
DE
L
AQYF
P
HG
LE
YKVAY
ET
T
SF
V
KA
SI
E
D
VVKT
L
LEAIA
LV
F
LV
MY
LFL
Q
N
F
RATLIP
T
IAVPV
V
L
M
GTF
SV
L
YAF
G
Y
S
V
N
T
LT
M
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
S
E
----------
EGLT
P
RE
A
TRKSMG
Q
I
Q
G
AL
VGIAMV
L
S
AVF
V
PM
AFFG
G
TT
G
A
I
Y
R
Q
F
S
I
T
IVA
AM
VL
S
VL
VA
M
I
LTP
A
LCA
TL
L
KPLKKGEHHGQKGFFAWFNQM
F
NRNAER
----
Y
EKGVAK
I
L
HRSLRWIV
I
YVLLLGGMV-
-
FLRL
P
TS
FLP
LE
D
R
G
MFTTSV
Q
LPS
G
S
T
QQQTLKVVEQIE
KYY
FTHEKDN
I
MS
VF
ATV
G
SGPGGNGQ
N
VARMF
---
I
R
LK
D
WS
E
-
R
DSKTGTSFA
II
E
R
A
TKAFNKIKEAR
V
I--
A
S
-
SPPA
I
SGLGSS
A
GFDME
L
QDHAGAGHD
AL
MAARN
QL
LAL
A
AEN
P
-E
L
TR
V
RH
N
G
LD
DSPQLQ
I
DI
D
QRK
A
Q
A
L
GV
A
I
D
D
INDT
L
Q
TA
W
G
SSY
V
NDFMDRGRV
K
K
V
Y
VQ
AAAPY
R
MLPDD
I
NLWY
V
R
N
KD
G
GMV
P
F
S
AF
A
TSRWET
G
S
PR
L
ERYNGYSAVE
I
VG
E
AAPGV
S
T
G
T
A
MDIMESLVKQ
L
--
P
NGFGLE
W
T
A
--MS
Y
Q
ERLSGAQAPA
L
YA
-
I
S
LLV
VFL
C
L
AA
LYES
WSV
P
FS
V
ML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LEN
DV
YFQV
G
L
L
TV
IGL
S
AKNAIL
I
-------
VEFA
NEMNQK-GHDLF
---
EA
TLH
A
CRQ
R
L
RPI
L
MT
S
LA
F
I
F
G
V
LP
M
AT
S
T
G
A
GS
G
GQHA
VG
TG
VMGGM
IS
A
T
I
LA
IY
FV
P
LF
F
VLV
R
R
R
F
PL
KPR
P
E
fig|562.375.peg.922
Escherichia coli EC4100B (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGNENSAEA
V
I
H
R
A
KMEFGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|344601.3.peg.4583
Escherichia coli B171 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMEFGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|340185.3.peg.4834
Escherichia coli E22 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMEFGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|340185.4.peg.5107
Escherichia coli E22 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMEFGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|679205.4.peg.2758
Escherichia coli MS 124-1 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMEFGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|749533.3.peg.2406
Escherichia coli MS 84-1 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMEFGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|585395.4.peg.4189
Escherichia coli O103:H2 str. 12009 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMEFGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|344601.5.peg.4834
Escherichia coli B171 (257-1019/1021)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMEFGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|573235.3.peg.4477
Escherichia coli O26:H11 str. 11368 (257-1019/1021)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMEFGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|525281.3.peg.3792
Escherichia coli 83972 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
Q
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
RE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|655817.3.peg.3849
Escherichia coli ABU 83972 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
Q
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
RE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|405955.13.peg.3687
Escherichia coli APEC O1 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
Q
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
RE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|405955.9.peg.3079
Escherichia coli APEC O1 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
Q
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
RE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|199310.1.peg.3941
Escherichia coli CFT073 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
Q
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
RE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|199310.4.peg.3796
Escherichia coli CFT073 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
Q
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
RE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|714962.3.peg.3724
Escherichia coli IHE3034 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
Q
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
RE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|749546.3.peg.1815
Escherichia coli MS 185-1 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
Q
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
RE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|749528.3.peg.4231
Escherichia coli MS 45-1 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
Q
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
RE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|585035.6.peg.3587
Escherichia coli S88 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
Q
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
RE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|656440.3.peg.3505
Escherichia coli TA206 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
Q
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
RE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|869729.3.peg.6
Escherichia coli UM146 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
Q
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
RE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|364106.7.peg.3660
Escherichia coli UTI89 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
Q
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
RE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|364106.8.peg.3661
Escherichia coli UTI89 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
Q
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
RE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|1040638.4.peg.1852
Escherichia coli O104:H4 str. LB226692 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|656408.3.peg.3689
Escherichia coli H591 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|595495.4.peg.650
Escherichia coli KO11 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|679207.4.peg.2470
Escherichia coli MS 107-1 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|679206.4.peg.4698
Escherichia coli MS 119-7 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|679204.3.peg.1000
Escherichia coli MS 145-7 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|656443.3.peg.4164
Escherichia coli TA271 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|566546.3.peg.4708
Escherichia coli W (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|566546.4.peg.3495
Escherichia coli W (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|409438.11.peg.3715
Escherichia coli SE11 (257-1019/1021)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|656417.3.peg.4107
Escherichia coli M605 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
RE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|753642.3.peg.4693
Escherichia coli NC101 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
RE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|685038.3.peg.3308
Escherichia coli O83:H1 str. NRG 857C (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
RE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|431946.3.peg.3234
Escherichia coli SE15 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
Q
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
RE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQEQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|316401.4.peg.4000
Escherichia coli ETEC H10407 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
IS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|6666666.5357.peg.2522
Escherichia coli TY-2482 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATPH
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|670897.3.peg.4068
Escherichia coli 2362-75 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
Q
E
VVKT
L
FEAII
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|562.376.peg.1659
Escherichia coli WV_060327 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
Q
E
VVKT
L
FEAII
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|358709.5.peg.4812
Escherichia coli 101-1 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|670888.3.peg.2982
Escherichia coli 1827-70 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|331112.3.peg.3237
Escherichia coli HS (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|331112.6.peg.3374
Escherichia coli HS (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|749547.3.peg.1020
Escherichia coli MS 187-1 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|585396.4.peg.4236
Escherichia coli O111:H- str. 11128 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMEFGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
EHYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|550677.3.peg.3822
Escherichia coli B354 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TAHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASQ
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|656379.3.peg.4005
Escherichia coli FVEC1302 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TAHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASQ
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|656380.3.peg.3924
Escherichia coli FVEC1412 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TAHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASQ
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|656393.3.peg.4313
Escherichia coli H299 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TAHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASQ
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|749549.3.peg.2017
Escherichia coli MS 198-1 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TAHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASQ
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|656437.3.peg.3690
Escherichia coli TA143 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TAHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASQ
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|656444.3.peg.4526
Escherichia coli TA280 (202-964/966)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TAHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASQ
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|585056.7.peg.3922
Escherichia coli UMN026 (257-1019/1021)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TAHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASQ
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|344610.3.peg.4782
Escherichia coli 53638 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VN
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|344610.7.peg.2970
Escherichia coli 53638 (257-1019/1021)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VN
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|585034.4.peg.3347
Escherichia coli IAI1 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
V
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|585034.5.peg.3345
Escherichia coli IAI1 (257-1019/1021)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
V
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|749545.3.peg.3813
Escherichia coli MS 182-1 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|749532.3.peg.1210
Escherichia coli MS 78-1 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|550676.3.peg.3416
Escherichia coli B185 (257-1019/1021)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|216592.1.peg.4196
Escherichia coli 042 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
K
-
R
NGDKNSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TAHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASQ
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|216592.3.peg.3689
Escherichia coli 042 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
K
-
R
NGDKNSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TAHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASQ
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|585397.7.peg.3929
Escherichia coli ED1a (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
P
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
Q
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
RE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|585397.9.peg.3926
Escherichia coli ED1a (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
P
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
Q
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
RE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|536056.3.peg.460
Escherichia coli DH1 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
L
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|83333.1.peg.3208
Escherichia coli K12 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
L
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|749538.3.peg.530
Escherichia coli MS 116-1 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
L
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|749548.3.peg.3972
Escherichia coli MS 196-1 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
L
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|316407.3.peg.3142
Escherichia coli W3110 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
L
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|316385.5.peg.3394
Escherichia coli str. K-12 substr. DH10B (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
L
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|511145.6.peg.3349
Escherichia coli str. K-12 substr. MG1655 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
L
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|701177.3.peg.4003
Escherichia coli O55:H7 str. CB9615 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDKAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
TN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|595496.3.peg.3248
Escherichia coli BW2952 (257-1019/1021)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
L
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|316385.7.peg.3468
Escherichia coli str. K-12 substr. DH10B (257-1019/1021)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
L
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|511145.12.peg.3365
Escherichia coli str. K-12 substr. MG1655 (251-1013/1015)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
L
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|656419.3.peg.4247
Escherichia coli M718 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|585055.8.peg.3721
Escherichia coli 55989 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
H
PI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|340184.3.peg.4288
Escherichia coli B7A (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VHM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|340184.6.peg.4493
Escherichia coli B7A (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VHM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|585055.6.peg.3718
Escherichia coli 55989 (257-1019/1021)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NSDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
H
PI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|362663.8.peg.3389
Escherichia coli 536 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
Q
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
RE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPRT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|362663.9.peg.3401
Escherichia coli 536 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
Q
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
RE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPRT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|340197.3.peg.3941
Escherichia coli F11 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
Q
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
RE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPRT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|340197.5.peg.4117
Escherichia coli F11 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
Q
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
RE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPRT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|749550.3.peg.1298
Escherichia coli MS 200-1 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
Q
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
RE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPRT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|216593.1.peg.4876
Escherichia coli E2348/69 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
Q
E
VVKT
L
FEAII
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
I
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGAFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|574521.7.peg.3616
Escherichia coli O127:H6 str. E2348/69 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
Q
E
VVKT
L
FEAII
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
I
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGAFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|656414.3.peg.3746
Escherichia coli H736 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
L
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
L
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|749540.3.peg.3425
Escherichia coli MS 146-1 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
L
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
L
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|511693.5.peg.3285
Escherichia coli BL21 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
H
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|481805.3.peg.466
Escherichia coli ATCC 8739 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVE
K
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|413997.3.peg.3273
Escherichia coli B str. REL606 (257-1019/1021)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
H
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|469008.4.peg.492
Escherichia coli BL21(DE3) (257-1019/1021)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
H
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|340186.3.peg.4745
Escherichia coli E110019 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALV
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNALPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|481805.6.peg.468
Escherichia coli ATCC 8739 (257-1019/1021)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVE
K
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|340186.5.peg.5008
Escherichia coli E110019 (257-1019/1021)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALV
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNALPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|331111.3.peg.1417
Escherichia coli E24377A (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
S
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|331111.12.peg.4004
Escherichia coli E24377A (257-1019/1021)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPTSAEHHENKGGFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
S
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
NGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TSHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|749531.3.peg.2480
Escherichia coli MS 69-1 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
G
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGSFFGWFNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TAHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENLASQ
L
--
P
AGIDYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|749527.3.peg.2193
Escherichia coli MS 21-1 (270-1032/1034)
LG
G
E
N
Y
NV
IAR
I
N
D
K
-
P
A
AGLG
I
KLAT
GAN
ALD
T
AKA
I
KAK
L
AE
L
QPFF
P
QG
M
K
VLYPY
D
T
T
PF
V
QL
SI
H
E
VVKT
L
FEAIM
LV
F
LV
MY
LFL
Q
N
M
RATLIP
T
IAVPV
V
L
L
GTF
AI
L
AAF
G
Y
S
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
M
M
E
----------
DKLP
P
KE
A
TEKSMS
Q
I
Q
G
AL
VGIAMV
L
S
AVFIPM
AFFG
G
ST
G
A
I
Y
R
Q
F
S
I
T
IVS
AM
AL
S
VL
VAL
I
LTP
A
LCA
TL
L
KPVSAEHHENKGGFFGWVNTT
F
DHSVNH
----
Y
TNSVGK
I
L
GSTGRYLL
I
YALIVAGMVV
L
FLRL
P
SS
FLP
EE
D
Q
G
VFLTMI
Q
LPA
G
A
T
QERTQKVLDQVT
D
YY
LKNEKAN
V
ES
VF
TVN
G
FSFSGQAQ
N
AGMAF
---
V
S
LKP
WE
E
-
R
SGDENSAEA
V
I
H
R
A
KMELGKIRDGF
V
I--
P
F
-
NMPA
I
VELGTA
T
GFDFE
L
IDQAGLGHD
AL
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
L
E
DTAQFK
L
EV
D
QEK
A
Q
A
L
GV
S
L
S
D
INQT
I
S
TA
L
G
GTY
V
NDFIDRGRV
K
K
V
Y
VQ
ADAKF
R
MLPED
V
DKLY
V
R
S
AN
G
EMV
P
F
S
AF
T
TAHWVY
G
S
PR
L
ERYNGLPSME
I
QG
E
AAPGT
S
S
G
D
A
MALMENIASK
L
--
P
AGIGYD
W
T
G
--MS
Y
Q
ERLSGNQAPA
L
VA
-
I
S
FVV
VFL
C
L
AA
LYES
WSI
P
VS
V
ML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QKN
DV
YFMV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
KDLMEKEGKGVV
---
EA
TLM
A
VRM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
AI
S
N
G
A
GS
G
AQNA
VG
IG
VMGGM
VS
A
T
LLA
I
F
FV
P
VF
F
VVI
R
R
C
F
fig|562.371.peg.3299
Escherichia coli 1044A (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|562.373.peg.1711
Escherichia coli 1125A (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|562.372.peg.4181
Escherichia coli 1212A (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|562.374.peg.5134
Escherichia coli 536A (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|83334.1.peg.4365
Escherichia coli O157:H7 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|444454.5.peg.3479
Escherichia coli O157:H7 str. EC4024 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|444449.5.peg.2933
Escherichia coli O157:H7 str. EC4042 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|444448.5.peg.1687
Escherichia coli O157:H7 str. EC4045 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|444453.5.peg.1218
Escherichia coli O157:H7 str. EC4076 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|444452.5.peg.124
Escherichia coli O157:H7 str. EC4113 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|444450.8.peg.4768
Escherichia coli O157:H7 str. EC4115 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|444451.5.peg.298
Escherichia coli O157:H7 str. EC4196 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|444447.5.peg.1850
Escherichia coli O157:H7 str. EC4206 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|478004.5.peg.244
Escherichia coli O157:H7 str. EC4401 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|478005.5.peg.201
Escherichia coli O157:H7 str. EC4486 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|478006.5.peg.209
Escherichia coli O157:H7 str. EC4501 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|478007.5.peg.217
Escherichia coli O157:H7 str. EC508 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|478008.5.peg.738
Escherichia coli O157:H7 str. EC869 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|637388.3.peg.1929
Escherichia coli O157:H7 str. FRIK2000 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|570506.3.peg.91
Escherichia coli O157:H7 str. FRIK966 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|386585.9.peg.4592
Escherichia coli O157:H7 str. Sakai (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|544404.4.peg.4579
Escherichia coli O157:H7 str. TW14359 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|502346.5.peg.2251
Escherichia coli O157:H7 str. TW14588 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|701177.3.peg.4269
Escherichia coli O55:H7 str. CB9615 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|550677.3.peg.4076
Escherichia coli B354 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TNSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|656379.3.peg.4834
Escherichia coli FVEC1302 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TNSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|656380.3.peg.4621
Escherichia coli FVEC1412 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TNSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|749549.3.peg.2217
Escherichia coli MS 198-1 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TNSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|585056.7.peg.4188
Escherichia coli UMN026 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TNSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|550676.3.peg.3693
Escherichia coli B185 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|749531.3.peg.1632
Escherichia coli MS 69-1 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|656437.3.peg.3955
Escherichia coli TA143 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|1040638.4.peg.2143
Escherichia coli O104:H4 str. LB226692 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|585055.6.peg.3988
Escherichia coli 55989 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|585055.8.peg.3990
Escherichia coli 55989 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|550672.3.peg.3562
Escherichia coli B088 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|340184.3.peg.341
Escherichia coli B7A (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|340184.6.peg.355
Escherichia coli B7A (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|340186.3.peg.1646
Escherichia coli E110019 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|340186.5.peg.1697
Escherichia coli E110019 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|331111.12.peg.4241
Escherichia coli E24377A (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|331111.3.peg.1653
Escherichia coli E24377A (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|562.375.peg.4874
Escherichia coli EC4100B (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|656408.3.peg.3945
Escherichia coli H591 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|595495.4.peg.1385
Escherichia coli KO11 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|679207.4.peg.287
Escherichia coli MS 107-1 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|749537.3.peg.596
Escherichia coli MS 115-1 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|679206.4.peg.1869
Escherichia coli MS 119-7 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|749545.3.peg.4577
Escherichia coli MS 182-1 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|749532.3.peg.3889
Escherichia coli MS 78-1 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|585396.4.peg.4477
Escherichia coli O111:H- str. 11128 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|409438.11.peg.3956
Escherichia coli SE11 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|656443.3.peg.4425
Escherichia coli TA271 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|656444.3.peg.4807
Escherichia coli TA280 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|566546.3.peg.1948
Escherichia coli W (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|566546.4.peg.3734
Escherichia coli W (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|670888.3.peg.2726
Escherichia coli 1827-70 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|344610.3.peg.88
Escherichia coli 53638 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|344610.7.peg.2711
Escherichia coli 53638 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|481805.3.peg.211
Escherichia coli ATCC 8739 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|481805.6.peg.218
Escherichia coli ATCC 8739 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|413997.3.peg.3526
Escherichia coli B str. REL606 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|511693.5.peg.3542
Escherichia coli BL21 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|469008.4.peg.238
Escherichia coli BL21(DE3) (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|595496.3.peg.3503
Escherichia coli BW2952 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|536056.3.peg.206
Escherichia coli DH1 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|316401.4.peg.4264
Escherichia coli ETEC H10407 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|656414.3.peg.4012
Escherichia coli H736 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|331112.3.peg.3483
Escherichia coli HS (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|331112.6.peg.3625
Escherichia coli HS (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|83333.1.peg.3447
Escherichia coli K12 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|749538.3.peg.4048
Escherichia coli MS 116-1 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|749540.3.peg.2558
Escherichia coli MS 146-1 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|749544.3.peg.2968
Escherichia coli MS 175-1 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|316407.3.peg.3615
Escherichia coli W3110 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|316385.5.peg.3639
Escherichia coli str. K-12 substr. DH10B (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|316385.7.peg.3723
Escherichia coli str. K-12 substr. DH10B (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|511145.12.peg.3622
Escherichia coli str. K-12 substr. MG1655 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|511145.6.peg.3604
Escherichia coli str. K-12 substr. MG1655 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|656419.3.peg.4527
Escherichia coli M718 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQA
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|216592.1.peg.781
Escherichia coli 042 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TNSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
L
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|216592.3.peg.3957
Escherichia coli 042 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TNSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
L
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|358709.5.peg.296
Escherichia coli 101-1 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LLL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|749548.3.peg.3917
Escherichia coli MS 196-1 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LA
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|753642.3.peg.4423
Escherichia coli NC101 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGDHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|155864.1.peg.4402
Escherichia coli O157:H7 EDL933 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
X
V
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|155864.8.peg.4349
Escherichia coli O157:H7 EDL933 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
X
V
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
I
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|749546.3.peg.3939
Escherichia coli MS 185-1 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
EKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|656393.3.peg.4588
Escherichia coli H299 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
L
M
A
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|679204.3.peg.4608
Escherichia coli MS 145-7 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VKMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|439855.10.peg.3963
Escherichia coli SMS-3-5 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMR
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|585034.4.peg.3585
Escherichia coli IAI1 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
AS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|585034.5.peg.3583
Escherichia coli IAI1 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
AS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|749547.3.peg.1992
Escherichia coli MS 187-1 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAA
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGVAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|431946.3.peg.3484
Escherichia coli SE15 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLIFAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|679205.4.peg.3318
Escherichia coli MS 124-1 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LIKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|749533.3.peg.5066
Escherichia coli MS 84-1 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LIKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|573235.3.peg.4719
Escherichia coli O26:H11 str. 11368 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
Q
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|585057.4.peg.4149
Escherichia coli IAI39 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|585057.6.peg.4157
Escherichia coli IAI39 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|749527.3.peg.4640
Escherichia coli MS 21-1 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|525281.3.peg.2964
Escherichia coli 83972 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|655817.3.peg.4126
Escherichia coli ABU 83972 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|199310.1.peg.4230
Escherichia coli CFT073 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|199310.4.peg.4061
Escherichia coli CFT073 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|749528.3.peg.2997
Escherichia coli MS 45-1 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|670897.3.peg.3837
Escherichia coli 2362-75 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|405955.13.peg.3957
Escherichia coli APEC O1 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|405955.9.peg.3311
Escherichia coli APEC O1 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|216593.1.peg.4245
Escherichia coli E2348/69 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|714962.3.peg.3989
Escherichia coli IHE3034 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|656417.3.peg.4383
Escherichia coli M605 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|574521.7.peg.3842
Escherichia coli O127:H6 str. E2348/69 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|685038.3.peg.3565
Escherichia coli O83:H1 str. NRG 857C (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|585035.6.peg.3851
Escherichia coli S88 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|656440.3.peg.3778
Escherichia coli TA206 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|562.376.peg.2729
Escherichia coli WV_060327 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|869729.3.peg.3796
Escherichia coli UM146 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TIYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|364106.7.peg.3957
Escherichia coli UTI89 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TIYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|364106.8.peg.3958
Escherichia coli UTI89 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TIYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|362663.8.peg.3645
Escherichia coli 536 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNTLFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAE
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|362663.9.peg.3658
Escherichia coli 536 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNTLFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAE
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|340197.3.peg.651
Escherichia coli F11 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNTLFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAE
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|340197.5.peg.675
Escherichia coli F11 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNTLFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAE
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|749550.3.peg.2940
Escherichia coli MS 200-1 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNTLFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAE
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|344601.3.peg.1354
Escherichia coli B171 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLCT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|344601.5.peg.1427
Escherichia coli B171 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLCT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|340185.3.peg.86
Escherichia coli E22 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLCT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|340185.4.peg.95
Escherichia coli E22 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLCT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|585395.4.peg.4435
Escherichia coli O103:H2 str. 12009 (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
EI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNALFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLCT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKDN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
DQ
V
TG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPI
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
VG
TG
VMGGM
FA
A
T
V
LA
IY
fig|585397.7.peg.4182
Escherichia coli ED1a (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNTLFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
A
G
TG
VMGGM
FA
A
T
V
LA
IY
fig|585397.9.peg.4179
Escherichia coli ED1a (270-1018/1037)
LG
A
E
D
Y
ST
V
AR
Y
N
G
K
-
P
A
AGIA
I
KLAT
GAN
ALD
T
SRA
V
KEE
L
NR
L
SAYF
P
AS
L
K
TVYPY
D
T
T
PF
I
KI
SI
Q
E
VFKT
L
VEAII
LV
F
LV
MY
LFL
Q
N
F
RAT
I
IP
T
IAVPV
V
I
L
GTF
AI
L
SAV
G
F
T
I
N
T
LT
M
F
G
M
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
V
I
A
E
----------
DKLP
P
KE
A
THKSMG
Q
I
Q
R
AL
VGIAVV
L
S
AVF
M
PM
AFMS
G
AT
G
E
I
Y
R
Q
F
S
I
T
LIS
S
M
LL
S
VF
VA
M
S
LTP
A
LCA
TI
L
KAAPEGGHK-PNTLFARFNTL
F
EKSTQH
----
Y
TDSTRS
L
L
RCTGRYMV
V
YLLICAGMAV
L
FLRT
P
TS
FLP
EE
D
Q
G
VFMTTA
Q
LPS
G
A
T
MVNTTKVLQQVT
D
YY
LTKEKNN
V
QS
VF
TVG
G
FGFSGQGQ
N
NGLAF
---
I
S
LKP
WS
E
-
R
VGEENSVTA
II
Q
R
A
MIALSSINKAV
V
F--
P
F
-
NLPA
V
AELGTA
S
GFDME
L
LDNGNLGHE
K
L
TQARN
E
L
LSL
A
AQS
P
NQ
V
IG
V
RP
N
G
L
E
DTPMFK
V
NV
N
AAK
A
E
A
M
GV
A
L
S
D
INQT
I
S
TA
F
G
SSY
V
NDFLNQGRV
K
K
V
Y
VQ
AGTPF
R
MLPDN
I
NQWY
V
R
N
AS
G
TMA
PLS
AY
S
STEWTY
G
S
PR
L
ERYNGIPSME
I
LG
E
AAAGK
S
T
G
D
A
MKFMADLVAK
L
--
P
AGVGYS
W
T
G
--LS
Y
Q
EALSSNQAPA
L
YA
-
I
S
LVV
VFL
A
L
AA
LYES
WSI
P
FS
V
ML
V
VP
L
G
V
VG
A
LLA
TDLR
G
LSN
DV
YFQV
G
L
L
TT
IGL
S
AKNAIL
I
-------
VEFA
VEMMQKEGKTPV
---
EA
IIE
A
ARM
R
L
RPI
L
MT
S
LA
F
I
L
G
V
LPL
VI
S
H
G
A
GS
G
AQNA
A
G
TG
VMGGM
FA
A
T
V
LA
IY
fig|405955.13.peg.1406
Escherichia coli APEC O1 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGADRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|405955.9.peg.1156
Escherichia coli APEC O1 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGADRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|714962.3.peg.1532
Escherichia coli IHE3034 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGADRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|585035.6.peg.1423
Escherichia coli S88 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGADRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|364106.7.peg.1603
Escherichia coli UTI89 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGADRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|364106.8.peg.1603
Escherichia coli UTI89 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGADRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|199310.1.peg.1711
Escherichia coli CFT073 (241-1002/1005)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|749527.3.peg.410
Escherichia coli MS 21-1 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGTENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|670897.3.peg.2458
Escherichia coli 2362-75 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|362663.8.peg.1356
Escherichia coli 536 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|362663.9.peg.1356
Escherichia coli 536 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|525281.3.peg.128
Escherichia coli 83972 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|655817.3.peg.1652
Escherichia coli ABU 83972 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|550677.3.peg.2753
Escherichia coli B354 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|199310.4.peg.1640
Escherichia coli CFT073 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|216593.1.peg.1927
Escherichia coli E2348/69 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|340197.3.peg.1121
Escherichia coli F11 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|340197.5.peg.1182
Escherichia coli F11 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|656393.3.peg.2062
Escherichia coli H299 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|656417.3.peg.1603
Escherichia coli M605 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|749546.3.peg.265
Escherichia coli MS 185-1 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|749550.3.peg.61
Escherichia coli MS 200-1 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|749528.3.peg.176
Escherichia coli MS 45-1 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|753642.3.peg.1821
Escherichia coli NC101 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|574521.7.peg.1509
Escherichia coli O127:H6 str. E2348/69 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|685038.3.peg.1335
Escherichia coli O83:H1 str. NRG 857C (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|431946.3.peg.1319
Escherichia coli SE15 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|439855.10.peg.1994
Escherichia coli SMS-3-5 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|562.376.peg.3163
Escherichia coli WV_060327 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|585057.4.peg.1712
Escherichia coli IAI39 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QQGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|585057.6.peg.1712
Escherichia coli IAI39 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QQGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|656444.3.peg.2023
Escherichia coli TA280 (251-1012/1015)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----IKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|749531.3.peg.294
Escherichia coli MS 69-1 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
STPSD
L
GKWF
V
R
G
SD
N
AMT
L
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|550676.3.peg.848
Escherichia coli B185 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YLVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
K
S
R
fig|656419.3.peg.1639
Escherichia coli M718 (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YLVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
K
S
R
fig|585397.7.peg.1507
Escherichia coli ED1a (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
Q
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
PE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRTARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|585397.9.peg.1501
Escherichia coli ED1a (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
Q
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
PE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRTARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
KPR
fig|562.373.peg.5239
Escherichia coli 1125A (271-1032/1035)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
KGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIVLV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFDRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YLVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGTDRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
S
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
F
VLV
K
R
L
F
AG
K
S
R
fig|869729.3.peg.2190
Escherichia coli UM146 (271-1020/1022)
M
G
S
E
D
Y
TA
I
G
K
L
N
G
H
-
P
S
AGVA
V
MLSP
GAN
ALN
T
ATL
V
KDK
I
AE
F
QRNM
P
QG
YD
IAYPK
D
S
T
EF
I
KI
S
V
E
D
VIQT
L
FEAIV
LV
V
C
V
MY
LFL
Q
N
L
RATLIP
A
L
AVPV
V
L
L
GTF
GV
L
ALF
G
Y
S
I
N
T
LTL
F
AM
V
L
A
I
G
L
LVDDAIVVVEN
VE
R
I
M
R
D
----------
EGLP
A
RE
A
TEKSMG
EI
S
G
AL
VAIALV
L
S
AVF
L
PM
AFFG
G
ST
G
V
I
Y
R
Q
F
S
I
T
IIS
AM
LL
S
VV
VAL
T
LTP
A
LC
G
SV
L
QHVPPH----KKGFFGAFNRF
Y
RRTEDK
----
Y
QRGVIY
VL
RRAARTMG
L
YVVLGGGMAL
M
MWKL
P
GS
FLP
TE
D
Q
G
EIMVQY
T
LPA
G
A
T
AARTAEVNRQIV
D
WF
LINEKAN
T
DV
I
F
TVD
G
FSFSGSGQ
N
TGMAF
---
V
S
LK
N
WS
Q
-
R
KGAENTAQA
I
A
L
R
A
TKELGTIRDAT
V
F--
A
M
-
TPPA
V
DGLGQS
N
GFTFE
L
LANGGADRE
T
L
LQMRN
QL
IEK
A
NQS
P
-E
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DI
D
SNK
A
V
S
L
G
L
S
L
N
D
VTDT
L
S
S
A
W
G
GTY
V
NDFIDRGRV
K
K
V
Y
I
Q
GDSEF
R
SAPSD
L
GKWF
V
R
G
SD
N
AMT
P
F
S
AF
A
TTRWLY
GP
ER
L
VRYNGSAAYE
I
QG
E
NATGF
S
S
G
D
A
MTKMEELANS
L
--
P
AGTTWA
W
S
G
--LS
L
Q
EKLASGQALS
L
YA
-
V
S
ILV
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LNN
DV
YFQV
A
L
L
TT
IGL
S
S
KNAIL
I
-------
VEFA
-EAAVAEGYSLS
---
R
A
ALR
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
T
G
A
G
A
N
SRIA
I
G
TG
II
GG
T
LT
A
T
LLA
I
F
FV
P
LF
L
fig|340186.3.peg.2459
Escherichia coli E110019 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
VI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|340186.5.peg.2538
Escherichia coli E110019 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
VI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|331111.12.peg.2648
Escherichia coli E24377A (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
VI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|331111.3.peg.110
Escherichia coli E24377A (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
VI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|656408.3.peg.2279
Escherichia coli H591 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
VI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|749545.3.peg.9
Escherichia coli MS 182-1 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
VI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|749532.3.peg.4102
Escherichia coli MS 78-1 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
VI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|585396.4.peg.2890
Escherichia coli O111:H- str. 11128 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
VI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|573235.3.peg.3051
Escherichia coli O26:H11 str. 11368 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
VI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|331112.3.peg.2074
Escherichia coli HS (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
F
T
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRHP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|331112.6.peg.2169
Escherichia coli HS (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
F
T
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRHP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|749538.3.peg.1297
Escherichia coli MS 116-1 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRHP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|749540.3.peg.198
Escherichia coli MS 146-1 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWKP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPTN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|701177.3.peg.2621
Escherichia coli O55:H7 str. CB9615 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
T
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
ND
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|316401.4.peg.2540
Escherichia coli ETEC H10407 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|749537.3.peg.891
Escherichia coli MS 115-1 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|749531.3.peg.2068
Escherichia coli MS 69-1 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|714962.3.peg.2349
Escherichia coli IHE3034 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LQLF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|869729.3.peg.1362
Escherichia coli UM146 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LQLF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|364106.7.peg.2376
Escherichia coli UTI89 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LQLF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|364106.8.peg.2379
Escherichia coli UTI89 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LQLF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|585397.7.peg.2438
Escherichia coli ED1a (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
VISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGA
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDEPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|585397.9.peg.2436
Escherichia coli ED1a (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
VISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGA
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDEPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|362663.8.peg.2127
Escherichia coli 536 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGA
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|362663.9.peg.2132
Escherichia coli 536 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGA
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|199310.1.peg.2533
Escherichia coli CFT073 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGA
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|199310.4.peg.2447
Escherichia coli CFT073 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGA
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|340197.3.peg.136
Escherichia coli F11 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGA
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|340197.5.peg.140
Escherichia coli F11 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGA
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|749546.3.peg.2834
Escherichia coli MS 185-1 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGA
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|749550.3.peg.1587
Escherichia coli MS 200-1 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGA
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|749528.3.peg.1605
Escherichia coli MS 45-1 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGA
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|685038.3.peg.2130
Escherichia coli O83:H1 str. NRG 857C (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGA
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|656440.3.peg.2060
Escherichia coli TA206 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGA
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|595495.4.peg.2944
Escherichia coli KO11 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
SA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAITQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|566546.3.peg.2498
Escherichia coli W (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
SA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAITQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|566546.4.peg.2220
Escherichia coli W (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
SA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAITQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|431946.3.peg.2049
Escherichia coli SE15 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
VISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
MR
FS
RK
P
K
fig|670897.3.peg.2992
Escherichia coli 2362-75 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|216593.1.peg.2686
Escherichia coli E2348/69 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|574521.7.peg.2267
Escherichia coli O127:H6 str. E2348/69 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|525281.3.peg.3879
Escherichia coli 83972 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
E
A
SAAIDRAMTQ
L
GV
P
SSVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|655817.3.peg.2519
Escherichia coli ABU 83972 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
E
A
SAAIDRAMTQ
L
GV
P
SSVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|656417.3.peg.2743
Escherichia coli M605 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
VISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|749547.3.peg.3116
Escherichia coli MS 187-1 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GS
D
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|749527.3.peg.1511
Escherichia coli MS 21-1 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
I
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|562.376.peg.3982
Escherichia coli WV_060327 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
VISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRVLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|562.376.peg.3984
Escherichia coli WV_060327 (218-962/967)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
VISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRVLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|595496.3.peg.2044
Escherichia coli BW2952 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|536056.3.peg.1669
Escherichia coli DH1 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|83333.1.peg.2052
Escherichia coli K12 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|316407.3.peg.2012
Escherichia coli W3110 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|316385.7.peg.2241
Escherichia coli str. K-12 substr. DH10B (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|511145.12.peg.2153
Escherichia coli str. K-12 substr. MG1655 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|511145.6.peg.2138
Escherichia coli str. K-12 substr. MG1655 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|358709.5.peg.524
Escherichia coli 101-1 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|344610.3.peg.2094
Escherichia coli 53638 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|344610.7.peg.4397
Escherichia coli 53638 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|481805.3.peg.1677
Escherichia coli ATCC 8739 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|481805.6.peg.1672
Escherichia coli ATCC 8739 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|413997.3.peg.2073
Escherichia coli B str. REL606 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|511693.5.peg.2104
Escherichia coli BL21 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|469008.4.peg.1628
Escherichia coli BL21(DE3) (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|749548.3.peg.2931
Escherichia coli MS 196-1 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|749549.3.peg.1281
Escherichia coli MS 198-1 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|316385.5.peg.2191
Escherichia coli str. K-12 substr. DH10B (197-941/946)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|216592.1.peg.2870
Escherichia coli 042 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RTK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTS
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQ
S
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|216592.3.peg.2416
Escherichia coli 042 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RTK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTS
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQ
S
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|405955.13.peg.2261
Escherichia coli APEC O1 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LQLF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
Y
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|405955.9.peg.1844
Escherichia coli APEC O1 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LQLF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
Y
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|585035.6.peg.2155
Escherichia coli S88 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LQLF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
Y
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|344601.3.peg.3239
Escherichia coli B171 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RS
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRM-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|344601.5.peg.3385
Escherichia coli B171 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RS
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRM-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|340185.3.peg.1200
Escherichia coli E22 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RS
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRM-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|340185.4.peg.1266
Escherichia coli E22 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RS
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRM-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|585395.4.peg.2671
Escherichia coli O103:H2 str. 12009 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RS
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRM-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|656414.3.peg.2435
Escherichia coli H736 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
V
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|585034.4.peg.2127
Escherichia coli IAI1 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
V
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|585034.5.peg.2122
Escherichia coli IAI1 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
V
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|679207.4.peg.3867
Escherichia coli MS 107-1 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
V
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|679206.4.peg.1592
Escherichia coli MS 119-7 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
V
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|679204.3.peg.106
Escherichia coli MS 145-7 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
V
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|749544.3.peg.958
Escherichia coli MS 175-1 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
V
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|409438.11.peg.2500
Escherichia coli SE11 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
V
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|656443.3.peg.2774
Escherichia coli TA271 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
V
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|439855.10.peg.1142
Escherichia coli SMS-3-5 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|585057.4.peg.991
Escherichia coli IAI39 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRVLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLP
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|585057.6.peg.988
Escherichia coli IAI39 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRVLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLP
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|656419.3.peg.2831
Escherichia coli M718 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLT
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|562.375.peg.2296
Escherichia coli EC4100B (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
V
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDFR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|656437.3.peg.2337
Escherichia coli TA143 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
V
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRSKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGTEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|585055.6.peg.2367
Escherichia coli 55989 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|585055.8.peg.2374
Escherichia coli 55989 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|550677.3.peg.1625
Escherichia coli B354 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|656444.3.peg.3049
Escherichia coli TA280 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|753642.3.peg.3015
Escherichia coli NC101 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAR
L
PE
L
QSTI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
VISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AT
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRK---QTRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RKKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQAN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
E
D
NGAEMN
L
IY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
MR
FS
RK
P
K
fig|550672.3.peg.1795
Escherichia coli B088 (197-941/946)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|656393.3.peg.3100
Escherichia coli H299 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RS
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLNW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|679205.4.peg.2971
Escherichia coli MS 124-1 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RS
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLNW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|749533.3.peg.435
Escherichia coli MS 84-1 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RS
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
VS
VPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLNW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|562.371.peg.4281
Escherichia coli 1044A (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGM
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
S
K
fig|562.373.peg.4606
Escherichia coli 1125A (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGM
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
S
K
fig|83334.1.peg.2888
Escherichia coli O157:H7 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGM
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
S
K
fig|155864.1.peg.2892
Escherichia coli O157:H7 EDL933 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGM
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
S
K
fig|155864.8.peg.2776
Escherichia coli O157:H7 EDL933 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGM
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
S
K
fig|444454.5.peg.1748
Escherichia coli O157:H7 str. EC4024 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGM
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
S
K
fig|444449.5.peg.1224
Escherichia coli O157:H7 str. EC4042 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGM
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
S
K
fig|444448.5.peg.5498
Escherichia coli O157:H7 str. EC4045 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGM
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
S
K
fig|444453.5.peg.3717
Escherichia coli O157:H7 str. EC4076 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGM
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
S
K
fig|444452.5.peg.3368
Escherichia coli O157:H7 str. EC4113 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGM
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
S
K
fig|444450.8.peg.3018
Escherichia coli O157:H7 str. EC4115 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGM
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
S
K
fig|444451.5.peg.3057
Escherichia coli O157:H7 str. EC4196 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGM
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
S
K
fig|444447.5.peg.119
Escherichia coli O157:H7 str. EC4206 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGM
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
S
K
fig|478004.5.peg.4590
Escherichia coli O157:H7 str. EC4401 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGM
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
S
K
fig|478005.5.peg.3684
Escherichia coli O157:H7 str. EC4486 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGM
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
S
K
fig|478006.5.peg.2303
Escherichia coli O157:H7 str. EC4501 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGM
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
S
K
fig|478007.5.peg.1816
Escherichia coli O157:H7 str. EC508 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGM
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
S
K
fig|478008.5.peg.3902
Escherichia coli O157:H7 str. EC869 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGM
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
S
K
fig|637388.3.peg.2193
Escherichia coli O157:H7 str. FRIK2000 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGM
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
S
K
fig|570506.3.peg.3473
Escherichia coli O157:H7 str. FRIK966 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGM
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
S
K
fig|386585.9.peg.3016
Escherichia coli O157:H7 str. Sakai (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGM
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
S
K
fig|544404.4.peg.2880
Escherichia coli O157:H7 str. TW14359 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGM
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
S
K
fig|502346.5.peg.4501
Escherichia coli O157:H7 str. TW14588 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGM
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
S
K
fig|656379.3.peg.2608
Escherichia coli FVEC1302 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
G
L
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
HD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|656380.3.peg.2168
Escherichia coli FVEC1412 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
G
L
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
HD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|585056.7.peg.2595
Escherichia coli UMN026 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
G
L
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
HD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|550676.3.peg.2373
Escherichia coli B185 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
M
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
V
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|1040638.4.peg.3158
Escherichia coli O104:H4 str. LB226692 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PA
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|562.372.peg.5779
Escherichia coli 1212A (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSI
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGM
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
S
K
fig|562.374.peg.1791
Escherichia coli 536A (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PE
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
LFL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSI
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGM
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RD
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
S
K
fig|6666666.5357.peg.268
Escherichia coli TY-2482 (276-1020/1025)
N
A
K
-
P
A
ILLM
I
RKLP
E
AN
IIQ
T
VDS
I
RAK
L
PA
L
QETI
P
AA
I
D
LQIAQ
DR
S
PT
I
RA
S
L
E
E
VEQT
L
IISVA
LV
I
LV
VF
F
FL
R
S
G
RAT
I
IP
A
V
AVPV
S
L
I
GTF
AA
M
YLC
G
F
S
L
N
N
L
S
L
M
A
L
T
IA
T
G
F
V
VDDAIVV
L
EN
IA
R
H
L
-
E
----------
AGMK
P
LQ
A
ALQGTR
E
V
G
F
T
V
LSMSLS
L
V
AVF
L
P
L
LLMG
G
LP
G
R
L
L
R
E
FA
V
T
LSV
A
I
GI
S
LL
V
S
L
T
LTP
M
M
C
G
WM
L
KASKPRE---QKRL-----RG
F
GRMLVA
LQQG
Y
GKSLKW
VL
NHTRLVGV
V
LLGTIALNIW
L
YISI
P
KT
F
F
P
EQ
D
T
G
VLMGGI
Q
ADQ
S
I
S
FQAMRGKLQDFM
K
--
IIRDDPA
V
DN
V
T
GFT
G
----GSRV
N
SGMMF
---
I
T
LKP
RG
E
-
R
S---ETAQQ
II
D
RL
RVKLAKEPGAN
L
FLM
A
V
-
QDIR
V
GGRQSN
A
SYQYT
L
LSD---DLA
AL
REWEP
K
I
RKK
L
ATL
P
-E
L
AD
V
NS
D
Q
Q
D
NGAEMN
L
VY
D
RDT
M
A
R
L
G
I
D
V
Q
A
ANSL
L
N
N
A
F
G
QRQ
I
STIYQPMNQ
Y
K
V
V
ME
VDPRY
T
QDISA
L
EKMF
V
I
N
NE
G
KAI
PLS
YF
A
KWQPAN
A
P
LS
V
NHQGLSAAST
I
SF
N
LPTGK
S
L
S
D
A
SAAIDRAMTQ
L
GV
P
STVRGS
F
A
G
TAQV
FQ
ETMNS--QVI
L
II
-
A
A
IAT
V
Y
I
V
L
GI
LYES
YVH
P
LT
I
L
S
T
L
P
S
A
G
VG
A
LLA
LELF
N
APF
SL
IALI
G
I
M
LL
IG
I
V
K
KNAI
M
M
-------
V
D
FA
LEAQRHGNLTPQ
---
EA
IFQ
A
CLL
R
F
RPI
M
MT
T
LA
A
L
F
G
A
LPL
VL
S
G
G
D
GSE
LRQP
L
G
IT
IV
GG
L
VM
S
Q
LL
T
L
Y
TT
P
VV
Y
LFF
DR
L
R
LR
FS
RK
P
K
fig|749540.3.peg.199
Escherichia coli MS 146-1 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LTAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|340185.3.peg.1199
Escherichia coli E22 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEI
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|340185.4.peg.1265
Escherichia coli E22 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEI
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|585395.4.peg.2670
Escherichia coli O103:H2 str. 12009 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEI
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|753642.3.peg.3016
Escherichia coli NC101 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
ISII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|362663.8.peg.2126
Escherichia coli 536 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|362663.9.peg.2131
Escherichia coli 536 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|405955.13.peg.2260
Escherichia coli APEC O1 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|405955.9.peg.1843
Escherichia coli APEC O1 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|199310.1.peg.2532
Escherichia coli CFT073 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|199310.4.peg.2446
Escherichia coli CFT073 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|714962.3.peg.2348
Escherichia coli IHE3034 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|656417.3.peg.2742
Escherichia coli M605 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|749546.3.peg.2833
Escherichia coli MS 185-1 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|749527.3.peg.1512
Escherichia coli MS 21-1 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|749531.3.peg.2069
Escherichia coli MS 69-1 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|585035.6.peg.2154
Escherichia coli S88 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|431946.3.peg.2048
Escherichia coli SE15 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|439855.10.peg.1143
Escherichia coli SMS-3-5 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|656440.3.peg.2059
Escherichia coli TA206 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|869729.3.peg.1363
Escherichia coli UM146 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|364106.7.peg.2375
Escherichia coli UTI89 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|364106.8.peg.2378
Escherichia coli UTI89 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|562.376.peg.3981
Escherichia coli WV_060327 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|344601.3.peg.3240
Escherichia coli B171 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEI
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
SPLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|344601.5.peg.3386
Escherichia coli B171 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEI
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
SPLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|670888.3.peg.4212
Escherichia coli 1827-70 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|481805.3.peg.1678
Escherichia coli ATCC 8739 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|481805.6.peg.1673
Escherichia coli ATCC 8739 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|595496.3.peg.2043
Escherichia coli BW2952 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|536056.3.peg.1670
Escherichia coli DH1 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|656393.3.peg.3099
Escherichia coli H299 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|331112.3.peg.2073
Escherichia coli HS (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|331112.6.peg.2168
Escherichia coli HS (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|83333.1.peg.2051
Escherichia coli K12 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|595495.4.peg.2945
Escherichia coli KO11 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|656419.3.peg.2830
Escherichia coli M718 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|749538.3.peg.1296
Escherichia coli MS 116-1 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|679205.4.peg.2972
Escherichia coli MS 124-1 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|749533.3.peg.436
Escherichia coli MS 84-1 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|566546.3.peg.2499
Escherichia coli W (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|566546.4.peg.2219
Escherichia coli W (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|316407.3.peg.2011
Escherichia coli W3110 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|316385.5.peg.2190
Escherichia coli str. K-12 substr. DH10B (268-1007/1023)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|316385.7.peg.2240
Escherichia coli str. K-12 substr. DH10B (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|511145.12.peg.2152
Escherichia coli str. K-12 substr. MG1655 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|511145.6.peg.2137
Escherichia coli str. K-12 substr. MG1655 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|585397.7.peg.2437
Escherichia coli ED1a (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEPRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|585397.9.peg.2435
Escherichia coli ED1a (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEPRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|340184.3.peg.3957
Escherichia coli B7A (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEI
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|340184.6.peg.4139
Escherichia coli B7A (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEI
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|749537.3.peg.892
Escherichia coli MS 115-1 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEI
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|585396.4.peg.2889
Escherichia coli O111:H- str. 11128 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEI
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|573235.3.peg.3050
Escherichia coli O26:H11 str. 11368 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEI
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|409438.11.peg.2499
Escherichia coli SE11 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEI
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|550672.3.peg.1794
Escherichia coli B088 (268-1007/1023)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|749528.3.peg.1606
Escherichia coli MS 45-1 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFIG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVGR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|749532.3.peg.4103
Escherichia coli MS 78-1 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GQGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LE
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|331111.12.peg.2647
Escherichia coli E24377A (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|331111.3.peg.109
Escherichia coli E24377A (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|656408.3.peg.2278
Escherichia coli H591 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GQGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LE
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|749545.3.peg.10
Escherichia coli MS 182-1 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GQGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LE
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|656444.3.peg.3048
Escherichia coli TA280 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|340186.3.peg.2458
Escherichia coli E110019 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
NY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|340186.5.peg.2537
Escherichia coli E110019 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
NY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|525281.3.peg.3878
Escherichia coli 83972 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|655817.3.peg.2518
Escherichia coli ABU 83972 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|585055.6.peg.2366
Escherichia coli 55989 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GQGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LE
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|585055.8.peg.2373
Escherichia coli 55989 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GQGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LE
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|344610.3.peg.2093
Escherichia coli 53638 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
G
T
N
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|344610.7.peg.4398
Escherichia coli 53638 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
G
T
N
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|216592.1.peg.2869
Escherichia coli 042 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---TLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
QGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|216592.3.peg.2415
Escherichia coli 042 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---TLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
QGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|585057.4.peg.992
Escherichia coli IAI39 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FTNMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
VEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|585057.6.peg.989
Escherichia coli IAI39 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FTNMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
VEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|316401.4.peg.2539
Escherichia coli ETEC H10407 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
N
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
SPLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|562.371.peg.4280
Escherichia coli 1044A (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|562.372.peg.5780
Escherichia coli 1212A (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|562.374.peg.1790
Escherichia coli 536A (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|83334.1.peg.2887
Escherichia coli O157:H7 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|155864.1.peg.2891
Escherichia coli O157:H7 EDL933 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|155864.8.peg.2775
Escherichia coli O157:H7 EDL933 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|478006.5.peg.2302
Escherichia coli O157:H7 str. EC4501 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|478008.5.peg.3901
Escherichia coli O157:H7 str. EC869 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|637388.3.peg.2194
Escherichia coli O157:H7 str. FRIK2000 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|570506.3.peg.3472
Escherichia coli O157:H7 str. FRIK966 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|386585.9.peg.3015
Escherichia coli O157:H7 str. Sakai (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|502346.5.peg.4502
Escherichia coli O157:H7 str. TW14588 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|550677.3.peg.1624
Escherichia coli B354 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVLI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|216593.1.peg.2687
Escherichia coli E2348/69 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
ERIIAA
----
Y
GQGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|574521.7.peg.2266
Escherichia coli O127:H6 str. E2348/69 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
ERIIAA
----
Y
GQGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|685038.3.peg.2129
Escherichia coli O83:H1 str. NRG 857C (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
D
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|550676.3.peg.2372
Escherichia coli B185 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LK
L
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
VV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|701177.3.peg.2620
Escherichia coli O55:H7 str. CB9615 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KVEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
F
L
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|340197.3.peg.135
Escherichia coli F11 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
P
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|340197.5.peg.139
Escherichia coli F11 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
P
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|749550.3.peg.1588
Escherichia coli MS 200-1 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
P
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|358709.5.peg.523
Escherichia coli 101-1 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
N
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|413997.3.peg.2072
Escherichia coli B str. REL606 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
N
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|511693.5.peg.2103
Escherichia coli BL21 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
N
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|469008.4.peg.1629
Escherichia coli BL21(DE3) (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
N
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|749547.3.peg.3117
Escherichia coli MS 187-1 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
N
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|749548.3.peg.2930
Escherichia coli MS 196-1 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
N
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|749549.3.peg.1282
Escherichia coli MS 198-1 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
N
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
EA
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|656379.3.peg.2607
Escherichia coli FVEC1302 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
N
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
ERIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FTNMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
N
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|656380.3.peg.2167
Escherichia coli FVEC1412 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
N
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
ERIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FTNMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
N
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|656437.3.peg.2336
Escherichia coli TA143 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
N
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
ERIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FTNMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
N
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|585056.7.peg.2594
Escherichia coli UMN026 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
N
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
ERIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FTNMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
N
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|562.373.peg.4607
Escherichia coli 1125A (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIT
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|444454.5.peg.1747
Escherichia coli O157:H7 str. EC4024 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIT
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|444449.5.peg.1223
Escherichia coli O157:H7 str. EC4042 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIT
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|444448.5.peg.5497
Escherichia coli O157:H7 str. EC4045 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIT
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|444453.5.peg.3716
Escherichia coli O157:H7 str. EC4076 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIT
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|444452.5.peg.3369
Escherichia coli O157:H7 str. EC4113 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIT
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|444450.8.peg.3017
Escherichia coli O157:H7 str. EC4115 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIT
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|444451.5.peg.3058
Escherichia coli O157:H7 str. EC4196 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIT
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|444447.5.peg.118
Escherichia coli O157:H7 str. EC4206 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIT
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|478004.5.peg.4589
Escherichia coli O157:H7 str. EC4401 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIT
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|478005.5.peg.3683
Escherichia coli O157:H7 str. EC4486 (268-1007/1023)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIT
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|478007.5.peg.1817
Escherichia coli O157:H7 str. EC508 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIT
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|544404.4.peg.2879
Escherichia coli O157:H7 str. TW14359 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIT
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
I
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|670897.3.peg.2991
Escherichia coli 2362-75 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
D
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
V
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALNGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
ERIIAA
----
Y
GQGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
QL
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|562.375.peg.2295
Escherichia coli EC4100B (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
N
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|656414.3.peg.2434
Escherichia coli H736 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
N
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|585034.4.peg.2126
Escherichia coli IAI1 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
N
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|585034.5.peg.2121
Escherichia coli IAI1 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
N
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|679207.4.peg.3868
Escherichia coli MS 107-1 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
N
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|679206.4.peg.1593
Escherichia coli MS 119-7 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
N
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|679204.3.peg.105
Escherichia coli MS 145-7 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
N
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|749544.3.peg.957
Escherichia coli MS 175-1 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
N
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|656443.3.peg.2773
Escherichia coli TA271 (285-1024/1040)
N
K
E
-
Q
A
IVMN
V
QRQP
GAN
IIS
T
ADS
I
RQM
L
PQ
L
TESL
P
KS
VK
VTVLS
DRT
TN
I
RA
S
V
N
D
TQFE
L
MMAIA
LV
V
M
I
IY
LFL
R
N
I
P
AT
I
IP
G
F
AVP
L
S
L
I
GTF
AV
M
VFL
D
F
S
I
N
N
LTL
M
A
L
T
IA
T
G
F
V
VDDAIVV
I
EN
IS
R
Y
I
-
E
----------
KGEK
P
LA
A
ALKGAG
EIG
F
T
I
ISLTFS
L
I
AV
L
IP
L
LFMG
D
IV
G
R
L
F
R
E
FA
I
T
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
SQESLRK---QNRFSRASEKM
F
DRIIAA
----
Y
GRGLAK
VL
NHPWLTLS
V
ALSTLLLSVL
L
WVFI
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
APQ
S
S
S
FANMAQRQRQVA
D
--
VILQDPA
V
QS
LT
SFV
G
VDGTNPSL
N
SARLQ
---
I
N
LKP
LD
E
-
R
D---DRVQK
V
I
A
RL
QTAVDKVPGVD
L
FLQ
P
T
-
QDLT
I
DTQVSR
T
QYQFT
L
QAT---SLD
AL
STWVP
E
L
MEK
L
QQL
P
-Q
L
SD
V
SS
D
W
Q
D
KGLVAY
V
NV
D
RDS
A
S
R
L
G
I
S
M
A
D
VDNA
L
Y
N
A
F
G
QRL
I
STIYTQANQ
Y
R
V
V
LE
HNTEN
T
PGLAA
L
DTIR
L
T
S
SD
G
GVV
PLS
SI
A
KIEQRF
A
P
LS
I
NHLDQFPVTT
I
SF
N
VPDNY
S
L
G
D
A
VQAIMDTEKT
L
NL
P
VDITTQ
F
Q
G
STLA
FQ
SALGS--TVW
L
IV
-
A
A
VVA
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SEL
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
-------
ID
FA
LAAEREQGMSPR
---
D
A
IYQ
A
CLL
R
F
RPI
L
MT
T
LA
A
L
L
G
A
LPL
ML
S
T
G
V
G
A
E
LRRP
L
G
IG
MV
GG
L
IV
S
Q
V
L
T
LF
TT
P
VI
Y
LLF
DR
fig|6666666.5357.peg.3438
Escherichia coli TY-2482 (268-1041/1048)
G
P
E
M
R
RG
IA
E
L
N
G
Q
G
E
V
AGGV
V
ILRS
G
K
N
ARD
V
ITA
V
RDK
L
ET
L
KASL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSSK
L
LEEFI
V
V
A
I
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
W
D
HQHP
GEQI
DNAT
R
WK
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
S
M
AG
A
AA
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPAETSNP------LNRV
L
IKA---
----
Y
HPLLLR
VL
HWPKTTLL
V
AALSIFTVIW
P
LSQV
G
GE
FLP
KI
N
E
G
DLLYMP
S
TLP
G
V
S
PAEAAALLQTTD
K
--
LIKSVPE
V
AS
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
ED
QW
R
PG--MTIDK
II
E
E
L
DRTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLSDID
A
T
AQ---
S
I
EAV
A
KTV
P
-G
V
VS
A
LA
E
R
L
E
GGRYID
V
DI
N
REK
A
S
R
Y
G
M
T
V
G
D
VQLF
I
S
S
A
I
G
GAT
V
GETVEGVAR
Y
P
I
N
IR
YPQDY
R
NSPQA
L
KQMP
I
L
T
PM
K
QQI
T
L
G
DV
A
DIKVVS
GP
TM
L
KTENARPASW
I
YI
D
ARGRD
M
V
S
V
V
NDIKTAISQK
V
KL
R
PGTSVS
F
S
G
---Q
F
E
LLEHANKKLK
L
MV
P
M
T
VMI
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FHM
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
H
PELSRKETFTPE
G
LD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLI
WL
R
fig|585055.6.peg.3944
Escherichia coli 55989 (268-1041/1048)
G
P
E
M
R
RG
IA
E
L
N
G
Q
G
E
V
AGGV
V
ILRS
G
K
N
ARD
V
ITA
V
RDK
L
ET
L
KASL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSSK
L
LEEFI
V
V
A
I
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
W
D
HQHP
GEQI
DNAT
R
WK
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
S
M
AG
A
AA
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPAETSNP------LNRV
L
IKA---
----
Y
HPLLLR
VL
HWPKTTLL
V
AALSIFTVIW
P
LSQV
G
GE
FLP
KI
N
E
G
DLLYMP
S
TLP
G
V
S
PAEAAALLQTTD
K
--
LIKSVPE
V
AS
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
ED
QW
R
PG--MTIDK
II
E
E
L
DRTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLSDID
A
T
AQ---
S
I
EAV
A
KTV
P
-G
V
VS
A
LA
E
R
L
E
GGRYID
V
DI
N
REK
A
S
R
Y
G
M
T
V
G
D
VQLF
I
S
S
A
I
G
GAT
V
GETVEGVAR
Y
P
I
N
IR
YPQDY
R
NSPQA
L
KQMP
I
L
T
PM
K
QQI
T
L
G
DV
A
DIKVVS
GP
TM
L
KTENARPASW
I
YI
D
ARGRD
M
V
S
V
V
NDIKTAISQK
V
KL
R
PGTSVS
F
S
G
---Q
F
E
LLEHANKKLK
L
MV
P
M
T
VMI
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FHM
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
H
PELSRKETFTPE
G
LD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLI
WL
R
fig|585055.8.peg.3946
Escherichia coli 55989 (268-1041/1048)
G
P
E
M
R
RG
IA
E
L
N
G
Q
G
E
V
AGGV
V
ILRS
G
K
N
ARD
V
ITA
V
RDK
L
ET
L
KASL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSSK
L
LEEFI
V
V
A
I
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
W
D
HQHP
GEQI
DNAT
R
WK
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
S
M
AG
A
AA
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPAETSNP------LNRV
L
IKA---
----
Y
HPLLLR
VL
HWPKTTLL
V
AALSIFTVIW
P
LSQV
G
GE
FLP
KI
N
E
G
DLLYMP
S
TLP
G
V
S
PAEAAALLQTTD
K
--
LIKSVPE
V
AS
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
ED
QW
R
PG--MTIDK
II
E
E
L
DRTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLSDID
A
T
AQ---
S
I
EAV
A
KTV
P
-G
V
VS
A
LA
E
R
L
E
GGRYID
V
DI
N
REK
A
S
R
Y
G
M
T
V
G
D
VQLF
I
S
S
A
I
G
GAT
V
GETVEGVAR
Y
P
I
N
IR
YPQDY
R
NSPQA
L
KQMP
I
L
T
PM
K
QQI
T
L
G
DV
A
DIKVVS
GP
TM
L
KTENARPASW
I
YI
D
ARGRD
M
V
S
V
V
NDIKTAISQK
V
KL
R
PGTSVS
F
S
G
---Q
F
E
LLEHANKKLK
L
MV
P
M
T
VMI
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FHM
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
H
PELSRKETFTPE
G
LD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLI
WL
R
fig|405955.13.peg.5316
Escherichia coli APEC O1 (268-1041/1048)
G
P
E
M
R
RG
IA
E
L
N
G
Q
G
E
V
AGGV
V
ILRS
G
K
N
ARD
V
ITA
V
RDK
L
ET
L
KASL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSSK
L
LEEFI
V
V
A
I
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
W
D
HQHP
GEQI
DNAT
R
WK
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
S
M
AG
A
AA
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPAETSNP------LNRV
L
IKA---
----
Y
HPLLLR
VL
HWPKTTLL
V
AALSIFTVIW
P
LSQV
G
GE
FLP
KI
N
E
G
DLLYMP
S
TLP
G
V
S
PAEAAALLQTTD
K
--
LIKSVPE
V
AS
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
ED
QW
R
PG--MTIDK
II
E
E
L
DRTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLSDID
A
T
AQ---
S
I
EAV
A
KTV
P
-G
V
VS
A
LA
E
R
L
E
GGRYID
V
DI
N
REK
A
S
R
Y
G
M
T
V
G
D
VQLF
I
S
S
A
I
G
GAT
V
GETVEGVAR
Y
P
I
N
IR
YPQDY
R
NSPQA
L
KQMP
I
L
T
PM
K
QQI
T
L
G
DV
A
DIKVVS
GP
TM
L
KTENARPASW
I
YI
D
ARGRD
M
V
S
V
V
NDIKTAISQK
V
KL
R
PGTSVS
F
S
G
---Q
F
E
LLEHANKKLK
L
MV
P
M
T
VMI
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FHM
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
H
PELSRKETFTPE
G
LD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLI
WL
R
fig|405955.9.peg.4433
Escherichia coli APEC O1 (268-1041/1048)
G
P
E
M
R
RG
IA
E
L
N
G
Q
G
E
V
AGGV
V
ILRS
G
K
N
ARD
V
ITA
V
RDK
L
ET
L
KASL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSSK
L
LEEFI
V
V
A
I
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
W
D
HQHP
GEQI
DNAT
R
WK
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
S
M
AG
A
AA
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPAETSNP------LNRV
L
IKA---
----
Y
HPLLLR
VL
HWPKTTLL
V
AALSIFTVIW
P
LSQV
G
GE
FLP
KI
N
E
G
DLLYMP
S
TLP
G
V
S
PAEAAALLQTTD
K
--
LIKSVPE
V
AS
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
ED
QW
R
PG--MTIDK
II
E
E
L
DRTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLSDID
A
T
AQ---
S
I
EAV
A
KTV
P
-G
V
VS
A
LA
E
R
L
E
GGRYID
V
DI
N
REK
A
S
R
Y
G
M
T
V
G
D
VQLF
I
S
S
A
I
G
GAT
V
GETVEGVAR
Y
P
I
N
IR
YPQDY
R
NSPQA
L
KQMP
I
L
T
PM
K
QQI
T
L
G
DV
A
DIKVVS
GP
TM
L
KTENARPASW
I
YI
D
ARGRD
M
V
S
V
V
NDIKTAISQK
V
KL
R
PGTSVS
F
S
G
---Q
F
E
LLEHANKKLK
L
MV
P
M
T
VMI
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FHM
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
H
PELSRKETFTPE
G
LD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLI
WL
R
fig|550676.3.peg.38
Escherichia coli B185 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HRPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
V
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|481805.3.peg.3679
Escherichia coli ATCC 8739 (268-1041/1048)
G
P
E
M
R
RG
IA
E
L
N
G
Q
G
E
V
AGGV
V
ILRS
G
K
N
ARD
V
ITA
V
KDK
L
DT
L
KASL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSSK
L
LEEFF
V
V
A
I
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
W
D
HQHP
GEQI
DNAT
R
WK
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
S
M
AG
A
AA
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPAETSNP------LNRV
L
IKA---
----
Y
HPLLLR
VL
HWPKTTLL
V
AALSIFTVIW
P
LSQV
G
GE
FLP
KI
N
E
G
DLLYMP
S
TLP
G
V
S
PAEAAALLQTTD
K
--
LIKSVPE
V
AS
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
ED
QW
R
PG--MTIDK
II
E
E
L
DRTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLSDID
VT
AQ---
S
I
EAV
A
KTV
P
-G
V
VS
A
LA
E
R
L
E
GGRYID
V
DI
N
REK
A
S
R
Y
G
M
T
V
G
D
VQLF
V
S
S
A
I
G
GAM
V
GETVEGVAR
Y
P
I
N
IR
YPQDY
R
NSPQA
L
REMP
I
L
T
PM
K
QQI
T
L
G
DV
A
DIKVVS
GP
TM
L
KTENARPASW
I
YV
D
ARGRD
M
V
S
V
V
NDIKTAISEK
V
KL
R
PGTSVA
F
S
G
---Q
F
E
LLEHANKKLK
L
MV
P
M
T
VMI
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FHM
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
H
PELSRKETFTPE
G
LD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLI
WL
R
fig|481805.6.peg.3657
Escherichia coli ATCC 8739 (268-1041/1048)
G
P
E
M
R
RG
IA
E
L
N
G
Q
G
E
V
AGGV
V
ILRS
G
K
N
ARD
V
ITA
V
KDK
L
DT
L
KASL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSSK
L
LEEFF
V
V
A
I
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
W
D
HQHP
GEQI
DNAT
R
WK
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
S
M
AG
A
AA
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPAETSNP------LNRV
L
IKA---
----
Y
HPLLLR
VL
HWPKTTLL
V
AALSIFTVIW
P
LSQV
G
GE
FLP
KI
N
E
G
DLLYMP
S
TLP
G
V
S
PAEAAALLQTTD
K
--
LIKSVPE
V
AS
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
ED
QW
R
PG--MTIDK
II
E
E
L
DRTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLSDID
VT
AQ---
S
I
EAV
A
KTV
P
-G
V
VS
A
LA
E
R
L
E
GGRYID
V
DI
N
REK
A
S
R
Y
G
M
T
V
G
D
VQLF
V
S
S
A
I
G
GAM
V
GETVEGVAR
Y
P
I
N
IR
YPQDY
R
NSPQA
L
REMP
I
L
T
PM
K
QQI
T
L
G
DV
A
DIKVVS
GP
TM
L
KTENARPASW
I
YV
D
ARGRD
M
V
S
V
V
NDIKTAISEK
V
KL
R
PGTSVA
F
S
G
---Q
F
E
LLEHANKKLK
L
MV
P
M
T
VMI
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FHM
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
H
PELSRKETFTPE
G
LD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLI
WL
R
fig|316401.4.peg.250
Escherichia coli ETEC H10407 (268-1041/1048)
G
P
E
M
R
RG
IA
E
L
N
G
Q
G
E
V
AGGV
V
ILRS
G
K
N
ARD
V
ITA
V
KDK
L
DT
L
KASL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSSK
L
LEEFF
V
V
A
I
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
W
D
HQHP
GEQI
DNAT
R
WK
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
S
M
AG
A
AA
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPAETSNP------LNRV
L
IKA---
----
Y
HPLLLR
VL
HWPKTTLL
V
AALSIFTVIW
P
LSQV
G
GE
FLP
KI
N
E
G
DLLYMP
S
TLP
G
V
S
PAEAAALLQTTD
K
--
LIKSVPE
V
AS
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
ED
QW
R
PG--MTIDK
II
E
E
L
DRTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLSDID
VT
AQ---
S
I
EAV
A
KTV
P
-G
V
VS
A
LA
E
R
L
E
GGRYID
V
DI
N
REK
A
S
R
Y
G
M
T
V
G
D
VQLF
V
S
S
A
I
G
GAM
V
GETVEGVAR
Y
P
I
N
IR
YPQDY
R
NSPQA
L
REMP
I
L
T
PM
K
QQI
T
L
G
DV
A
DIKVVS
GP
TM
L
KTENARPASW
I
YV
D
ARGRD
M
V
S
V
V
NDIKTAISEK
V
KL
R
PGTSVA
F
S
G
---Q
F
E
LLEHANKKLK
L
MV
P
M
T
VMI
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FHM
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
H
PELSRKETFTPE
G
LD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLI
WL
R
fig|562.371.peg.2826
Escherichia coli 1044A (267-1036/1045)
V
G
P
E
M
R
RG
IA
E
L
N
-
-
G
E
V
VGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITNASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LHH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|562.373.peg.3167
Escherichia coli 1125A (267-1036/1045)
V
G
P
E
M
R
RG
IA
E
L
N
-
-
G
E
V
VGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITNASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LHH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|562.372.peg.1557
Escherichia coli 1212A (267-1036/1045)
V
G
P
E
M
R
RG
IA
E
L
N
-
-
G
E
V
VGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITNASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LHH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|562.374.peg.5419
Escherichia coli 536A (267-1036/1045)
V
G
P
E
M
R
RG
IA
E
L
N
-
-
G
E
V
VGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITNASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LHH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|83334.1.peg.686
Escherichia coli O157:H7 (267-1036/1045)
V
G
P
E
M
R
RG
IA
E
L
N
-
-
G
E
V
VGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITNASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LHH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|155864.1.peg.608
Escherichia coli O157:H7 EDL933 (267-1036/1045)
V
G
P
E
M
R
RG
IA
E
L
N
-
-
G
E
V
VGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITNASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LHH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|155864.8.peg.623
Escherichia coli O157:H7 EDL933 (267-1036/1045)
V
G
P
E
M
R
RG
IA
E
L
N
-
-
G
E
V
VGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITNASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LHH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|444454.5.peg.5098
Escherichia coli O157:H7 str. EC4024 (267-1036/1045)
V
G
P
E
M
R
RG
IA
E
L
N
-
-
G
E
V
VGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITNASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LHH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|444449.5.peg.5434
Escherichia coli O157:H7 str. EC4042 (267-1036/1045)
V
G
P
E
M
R
RG
IA
E
L
N
-
-
G
E
V
VGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITNASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LHH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|444448.5.peg.3308
Escherichia coli O157:H7 str. EC4045 (267-1036/1045)
V
G
P
E
M
R
RG
IA
E
L
N
-
-
G
E
V
VGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITNASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LHH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|444453.5.peg.650
Escherichia coli O157:H7 str. EC4076 (267-1036/1045)
V
G
P
E
M
R
RG
IA
E
L
N
-
-
G
E
V
VGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITNASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LHH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|444452.5.peg.878
Escherichia coli O157:H7 str. EC4113 (267-1036/1045)
V
G
P
E
M
R
RG
IA
E
L
N
-
-
G
E
V
VGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITNASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LHH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|444450.8.peg.768
Escherichia coli O157:H7 str. EC4115 (267-1036/1045)
V
G
P
E
M
R
RG
IA
E
L
N
-
-
G
E
V
VGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITNASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LHH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|444451.5.peg.2270
Escherichia coli O157:H7 str. EC4196 (267-1036/1045)
V
G
P
E
M
R
RG
IA
E
L
N
-
-
G
E
V
VGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITNASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LHH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|444447.5.peg.3483
Escherichia coli O157:H7 str. EC4206 (267-1036/1045)
V
G
P
E
M
R
RG
IA
E
L
N
-
-
G
E
V
VGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITNASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LHH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|478004.5.peg.1476
Escherichia coli O157:H7 str. EC4401 (267-1036/1045)
V
G
P
E
M
R
RG
IA
E
L
N
-
-
G
E
V
VGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITNASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LHH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|478005.5.peg.3986
Escherichia coli O157:H7 str. EC4486 (267-1036/1045)
V
G
P
E
M
R
RG
IA
E
L
N
-
-
G
E
V
VGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITNASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LHH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|478006.5.peg.835
Escherichia coli O157:H7 str. EC4501 (267-1036/1045)
V
G
P
E
M
R
RG
IA
E
L
N
-
-
G
E
V
VGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITNASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LHH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|478007.5.peg.967
Escherichia coli O157:H7 str. EC508 (267-1036/1045)
V
G
P
E
M
R
RG
IA
E
L
N
-
-
G
E
V
VGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITNASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LHH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|478008.5.peg.1710
Escherichia coli O157:H7 str. EC869 (267-1036/1045)
V
G
P
E
M
R
RG
IA
E
L
N
-
-
G
E
V
VGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITNASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LHH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|637388.3.peg.1105
Escherichia coli O157:H7 str. FRIK2000 (267-1036/1045)
V
G
P
E
M
R
RG
IA
E
L
N
-
-
G
E
V
VGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITNASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LHH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|570506.3.peg.3642
Escherichia coli O157:H7 str. FRIK966 (267-1036/1045)
V
G
P
E
M
R
RG
IA
E
L
N
-
-
G
E
V
VGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITNASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LHH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|386585.9.peg.721
Escherichia coli O157:H7 str. Sakai (267-1036/1045)
V
G
P
E
M
R
RG
IA
E
L
N
-
-
G
E
V
VGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITNASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LHH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|544404.4.peg.633
Escherichia coli O157:H7 str. TW14359 (267-1036/1045)
V
G
P
E
M
R
RG
IA
E
L
N
-
-
G
E
V
VGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITNASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LHH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|502346.5.peg.588
Escherichia coli O157:H7 str. TW14588 (267-1036/1045)
V
G
P
E
M
R
RG
IA
E
L
N
-
-
G
E
V
VGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITNASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LHH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|749547.3.peg.3540
Escherichia coli MS 187-1 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
SG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|413997.3.peg.563
Escherichia coli B str. REL606 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
M
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|511693.5.peg.558
Escherichia coli BL21 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
M
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|469008.4.peg.3196
Escherichia coli BL21(DE3) (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
M
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|216592.1.peg.326
Escherichia coli 042 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|216592.3.peg.634
Escherichia coli 042 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|656414.3.peg.748
Escherichia coli H736 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|749540.3.peg.485
Escherichia coli MS 146-1 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|749537.3.peg.100
Escherichia coli MS 115-1 (268-1041/1048)
G
P
E
M
R
RG
IA
E
L
N
G
Q
G
E
V
AGGV
V
ILRS
G
K
N
ARD
V
ITA
V
RDK
L
ET
L
KASL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSSK
L
LEEFI
V
V
A
I
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
W
D
HQHP
GEQI
DNAT
R
WK
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
S
M
AG
A
AA
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPAETSNP------LNRV
L
IKA---
----
Y
HPLLLR
VL
HWPKTTLL
V
AALSIFTVIW
P
LSQV
G
GE
FLP
KI
N
E
G
DLLYMP
S
TLP
G
V
S
PAEAAALLQTTD
K
--
LIKSVPE
V
AS
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
ED
QW
R
PG--MTIDK
II
E
E
L
DRTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLSDID
VT
AQ---
S
I
EAV
A
KTV
P
-G
V
VS
A
LA
E
R
L
E
GGRYID
V
DI
N
REK
A
S
R
Y
G
M
T
V
G
D
VQLF
V
S
S
A
I
G
GAM
V
GETVEGVAR
Y
P
I
N
IR
YPQDY
R
NSPQA
L
REMP
I
L
T
PM
K
QQI
T
L
G
DV
A
DIKVVS
GP
TM
L
KTENARPASW
I
YV
D
ARGRD
M
V
S
V
V
NDIKTAISEK
V
KL
R
PGTSVA
F
S
G
---Q
F
E
LLEHANKKLK
L
MV
P
M
T
VMI
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FHM
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
H
PELSRKETFTPE
G
LD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLI
WL
R
fig|340186.3.peg.2228
Escherichia coli E110019 (267-1038/1047)
I
G
P
E
T
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAS
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|340186.5.peg.2300
Escherichia coli E110019 (267-1038/1047)
I
G
P
E
T
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAS
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|358709.5.peg.1979
Escherichia coli 101-1 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|670888.3.peg.1135
Escherichia coli 1827-70 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|344610.3.peg.1558
Escherichia coli 53638 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|344610.7.peg.1121
Escherichia coli 53638 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|481805.3.peg.3294
Escherichia coli ATCC 8739 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|481805.6.peg.3280
Escherichia coli ATCC 8739 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|550672.3.peg.142
Escherichia coli B088 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|595496.3.peg.496
Escherichia coli BW2952 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|536056.3.peg.3227
Escherichia coli DH1 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|340185.3.peg.1764
Escherichia coli E22 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|340185.4.peg.1859
Escherichia coli E22 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|331112.3.peg.579
Escherichia coli HS (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|331112.6.peg.606
Escherichia coli HS (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|585034.4.peg.550
Escherichia coli IAI1 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|585034.5.peg.549
Escherichia coli IAI1 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|83333.1.peg.573
Escherichia coli K12 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|679207.4.peg.2892
Escherichia coli MS 107-1 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|749538.3.peg.2539
Escherichia coli MS 116-1 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|679205.4.peg.578
Escherichia coli MS 124-1 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|749544.3.peg.295
Escherichia coli MS 175-1 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|749548.3.peg.3348
Escherichia coli MS 196-1 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|749533.3.peg.5382
Escherichia coli MS 84-1 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|585395.4.peg.609
Escherichia coli O103:H2 str. 12009 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|573235.3.peg.654
Escherichia coli O26:H11 str. 11368 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|316407.3.peg.556
Escherichia coli W3110 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|316385.5.peg.527
Escherichia coli str. K-12 substr. DH10B (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|316385.5.peg.638
Escherichia coli str. K-12 substr. DH10B (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|316385.7.peg.535
Escherichia coli str. K-12 substr. DH10B (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|316385.7.peg.646
Escherichia coli str. K-12 substr. DH10B (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|511145.12.peg.599
Escherichia coli str. K-12 substr. MG1655 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|511145.6.peg.590
Escherichia coli str. K-12 substr. MG1655 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|656419.3.peg.850
Escherichia coli M718 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVIW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|656437.3.peg.647
Escherichia coli TA143 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
I
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRA---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
M
L
S
LF
II
P
AA
Y
KLM
fig|749531.3.peg.3440
Escherichia coli MS 69-1 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRA---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
NSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVT
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
V
E
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|749537.3.peg.4060
Escherichia coli MS 115-1 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|656408.3.peg.504
Escherichia coli H591 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
TALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|679206.4.peg.4715
Escherichia coli MS 119-7 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
TALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|550677.3.peg.993
Escherichia coli B354 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|340184.3.peg.4467
Escherichia coli B7A (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|340184.6.peg.4678
Escherichia coli B7A (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|331111.12.peg.899
Escherichia coli E24377A (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|331111.3.peg.3124
Escherichia coli E24377A (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|562.375.peg.1588
Escherichia coli EC4100B (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|595495.4.peg.2045
Escherichia coli KO11 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|679204.3.peg.5117
Escherichia coli MS 145-7 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|749532.3.peg.3646
Escherichia coli MS 78-1 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|409438.11.peg.764
Escherichia coli SE11 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|566546.3.peg.4930
Escherichia coli W (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|566546.4.peg.631
Escherichia coli W (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|362663.8.peg.608
Escherichia coli 536 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VSE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|362663.9.peg.609
Escherichia coli 536 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VSE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|340197.3.peg.2412
Escherichia coli F11 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VSE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|340197.5.peg.2530
Escherichia coli F11 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VSE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|749550.3.peg.4627
Escherichia coli MS 200-1 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VSE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|344601.3.peg.2299
Escherichia coli B171 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
S
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
Q
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|344601.5.peg.2400
Escherichia coli B171 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
S
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
Q
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|656379.3.peg.1353
Escherichia coli FVEC1302 (282-1038/1047)
G
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
I
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRA---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|656380.3.peg.1181
Escherichia coli FVEC1412 (282-1038/1047)
G
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
I
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRA---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|749549.3.peg.4797
Escherichia coli MS 198-1 (282-1038/1047)
G
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
I
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRA---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|585056.7.peg.862
Escherichia coli UMN026 (282-1038/1047)
G
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
I
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRA---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|656444.3.peg.1047
Escherichia coli TA280 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTN
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|714962.3.peg.600
Escherichia coli IHE3034 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
AMGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|869729.3.peg.3132
Escherichia coli UM146 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
AMGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|364106.7.peg.680
Escherichia coli UTI89 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
AMGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|364106.8.peg.678
Escherichia coli UTI89 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
AMGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|1040638.4.peg.5263
Escherichia coli O104:H4 str. LB226692 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
T
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|6666666.5357.peg.2328
Escherichia coli TY-2482 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
T
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|585055.6.peg.576
Escherichia coli 55989 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
T
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|585055.8.peg.577
Escherichia coli 55989 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
T
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|749527.3.peg.4942
Escherichia coli MS 21-1 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AQ
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
K
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|316401.4.peg.692
Escherichia coli ETEC H10407 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
PFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDA
M
L
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
A
V
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|525281.3.peg.2364
Escherichia coli 83972 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|655817.3.peg.665
Escherichia coli ABU 83972 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|585397.7.peg.568
Escherichia coli ED1a (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|585397.9.peg.570
Escherichia coli ED1a (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|585057.4.peg.586
Escherichia coli IAI39 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|585057.6.peg.584
Escherichia coli IAI39 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|656417.3.peg.694
Escherichia coli M605 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|749546.3.peg.3398
Escherichia coli MS 185-1 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|749528.3.peg.4064
Escherichia coli MS 45-1 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|753642.3.peg.1083
Escherichia coli NC101 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|685038.3.peg.517
Escherichia coli O83:H1 str. NRG 857C (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|585035.6.peg.608
Escherichia coli S88 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|439855.10.peg.762
Escherichia coli SMS-3-5 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|562.376.peg.2042
Escherichia coli WV_060327 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|431946.3.peg.521
Escherichia coli SE15 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
W
L
HQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|656393.3.peg.1249
Escherichia coli H299 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETTTDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|749545.3.peg.4929
Escherichia coli MS 182-1 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
T
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|656440.3.peg.427
Escherichia coli TA206 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTALW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|199310.1.peg.636
Escherichia coli CFT073 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
XNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|199310.4.peg.626
Escherichia coli CFT073 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
XNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|670897.3.peg.172
Escherichia coli 2362-75 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVFT
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|216593.1.peg.3046
Escherichia coli E2348/69 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVFT
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|574521.7.peg.511
Escherichia coli O127:H6 str. E2348/69 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVFT
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|585396.4.peg.625
Escherichia coli O111:H- str. 11128 (267-1038/1047)
I
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
L
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QE
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
A
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DIKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|405955.13.peg.550
Escherichia coli APEC O1 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
G
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
fig|405955.9.peg.452
Escherichia coli APEC O1 (267-1038/1047)
V
G
P
E
M
R
RG
IA
E
L
N
G
EG
E
V
AGGV
V
ILRS
G
K
N
ARE
V
IAA
V
KDK
L
ET
L
KSSL
P
EG
V
E
IVTTY
DR
S
QL
I
DR
A
I
D
N
LSGK
L
LEEFI
V
V
A
V
V
CA
LFL
W
H
V
R
SA
L
VA
I
I
SL
P
L
G
L
C
IA
F
IV
M
HFQ
G
L
N
A
N
I
MS
L
G
G
I
A
IA
V
G
A
M
VD
A
AIV
M
I
EN
AH
K
R
L
E
E
WQHQHPDATL
DNKT
R
WQ
V
ITDASV
E
V
G
P
AL
FISLLI
I
T
LS
FIP
I
FTLE
G
QE
G
R
L
F
G
P
L
A
F
T
KTY
AM
AG
A
AL
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPPESSNP------LNRF
L
IRV---
----
Y
HPLLLK
VL
HWPKTTLL
V
AALSVLTVLW
P
LNKV
G
GE
FLP
QI
N
E
G
DLLYMP
S
TLP
G
I
S
AAEAASMLQKTD
K
--
LIMSVPE
V
AR
VF
GKT
G
KAETATDS
A
PLEMV
ETT
I
Q
LKP
QD
QW
R
PG--MTMDK
II
E
E
L
DNTVRLPGLAN
L
WVP
P
I
R
NRID
M
LSTGIK
S
PIGIK
V
SGTVLADID
T
M
AE---
Q
I
EEV
A
RTV
P
-G
V
AS
A
LA
E
R
L
E
GGRYIN
V
EI
N
REK
A
A
R
Y
G
M
T
V
A
D
VQLF
V
T
S
A
V
G
GAM
V
GETVEGIAR
Y
P
I
N
LR
YPQSW
R
DSPQA
L
RQLP
I
L
T
PM
K
QQI
T
L
A
DV
A
DVKVST
GP
SM
L
KTENARPTSW
I
YI
D
ARDRD
M
V
S
V
V
HDLQKAIAEK
V
QL
K
PGTSVA
F
S
G
---Q
F
E
LLERANHKLK
L
MV
P
M
T
LMI
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FHL
S
V
ATGT
G
F
I
AL
A
G
G
A
A
EFGV
V
M
LMYLRHAI
E
AE
PSLNNPQTFSEQ
KLD
EA
LYH
G
AVL
R
V
RP
K
A
MT
V
AV
I
I
A
G
L
LP
I
LW
G
T
G
A
GSE
VMSR
I
A
AP
MI
GGM
IT
A
P
LL
S
LF
II
P
AA
Y
KLM
Consen1
Primary consensus
lG
E
y
iar
N
k
-
a
v
gaN
t
v
L
L
P
vk
drt
i
si
e
L
lV
lv
LFL
n
ratlip
iavPv
l
gtF
m
g
s
N
ltl
am
iA
G
lVDdAIVvvEN
r
l
E
----------
p
a
eig
al
l
avfiPm
g
G
l
r
fa
T
am
s
val
ltP
lca
l
f
----
Y
vL
v
l
p
FlP
d
G
q
g
s
d
--
v
vf
G
n
---
i
LKp
e
-
R
iI
rl
l
p
-
i
s
l
al
ql
a
P
l
v
n
ld
v
d
a
r
Gv
v
d
l
tA
G
v
y
v
vq
r
l
v
n
g
pls
a
gp
l
I
e
s
g
a
l
p
f
g
fq
L
-
s
vfl
L
lyes
p
iml
vP
a
vG
lla
g
dv
G
l
iGl
aknailm
-------
vefa
---
eA
a
R
RPi
MT
la
i
G
LPl
s
G
Gse
vg
vmGGm
a
lLalf
P
y
dR
f
kpRkeK
Consen2
Secondary consensus
r
se
eg
v
i
ek
v
i
ets
v
a
v
i
psaiva
vsl
l
i
ia
l
d
msm
g
l
a
m
k
wqhqhpdatl
r
v
qvq
t
i
lsl
d
i
g
ls
si
a
ls
vi
mmg
i
l
lqqg
i
p
g
f
n
s
s
t
kyy
i
lt
a
ettv
d
qw
v
ea
v
a
r
v
km
i
l
v
a
qe
n
m
a
a
i
k
i
t
k
tfa
as
m
s
v
v
k
w
a
ye
p
y
afrr
a
v
s
l
g
i
iwl
n
sl
a
kefgv
ilmylrhaidae
kldd
g
k
av
l
g
ag
a
l
s
iy
f
r
r
fs
pp
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character