fig|1040638.4.peg.2844
Escherichia coli O104:H4 str. LB226692
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
S
LF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
S
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|6666666.5357.peg.4675
Escherichia coli TY-2482
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
S
LF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
S
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|585055.6.peg.2747
Escherichia coli 55989
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
S
LF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
S
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|585055.8.peg.2752
Escherichia coli 55989
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
S
LF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
S
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|344601.3.peg.1542
Escherichia coli B171
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|344601.5.peg.1616
Escherichia coli B171
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|340186.3.peg.1619
Escherichia coli E110019
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|340186.3.peg.4427
Escherichia coli E110019
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|340186.3.peg.4927
Escherichia coli E110019
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|340186.5.peg.1669
Escherichia coli E110019
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|340186.5.peg.4653
Escherichia coli E110019
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|340185.3.peg.3088
Escherichia coli E22
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|340185.4.peg.3252
Escherichia coli E22
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|331111.12.peg.2985
Escherichia coli E24377A
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|331111.3.peg.437
Escherichia coli E24377A
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|562.375.peg.3408
Escherichia coli EC4100B
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|656408.3.peg.2716
Escherichia coli H591
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|585034.4.peg.2451
Escherichia coli IAI1
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|585034.5.peg.2449
Escherichia coli IAI1
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|595495.4.peg.2540
Escherichia coli KO11
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|679207.4.peg.2333
Escherichia coli MS 107-1
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|679206.4.peg.683
Escherichia coli MS 119-7
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|679205.4.peg.4708
Escherichia coli MS 124-1
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|749545.3.peg.386
Escherichia coli MS 182-1
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|749533.3.peg.1228
Escherichia coli MS 84-1
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|585395.4.peg.3084
Escherichia coli O103:H2 str. 12009
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|585396.4.peg.3257
Escherichia coli O111:H- str. 11128
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|573235.3.peg.3545
Escherichia coli O26:H11 str. 11368
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|409438.11.peg.2884
Escherichia coli SE11
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|656443.3.peg.3181
Escherichia coli TA271
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|566546.3.peg.2725
Escherichia coli W
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|566546.4.peg.2629
Escherichia coli W
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|670888.3.peg.3862
Escherichia coli 1827-70
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|344610.3.peg.379
Escherichia coli 53638
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|344610.7.peg.3903
Escherichia coli 53638
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|481805.3.peg.1338
Escherichia coli ATCC 8739
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|481805.6.peg.1339
Escherichia coli ATCC 8739
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|595496.3.peg.2405
Escherichia coli BW2952
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|536056.3.peg.1296
Escherichia coli DH1
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|316401.4.peg.2904
Escherichia coli ETEC H10407
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|656414.3.peg.2801
Escherichia coli H736
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|331112.3.peg.2404
Escherichia coli HS
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|331112.6.peg.2509
Escherichia coli HS
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|83333.1.peg.2397
Escherichia coli K12
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|749537.3.peg.4730
Escherichia coli MS 115-1
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|749540.3.peg.4387
Escherichia coli MS 146-1
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|749548.3.peg.1962
Escherichia coli MS 196-1
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|316407.3.peg.2359
Escherichia coli W3110
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|316385.7.peg.2615
Escherichia coli str. K-12 substr. DH10B
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|511145.12.peg.2524
Escherichia coli str. K-12 substr. MG1655
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|511145.6.peg.2509
Escherichia coli str. K-12 substr. MG1655
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|749538.3.peg.4795
Escherichia coli MS 116-1
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
F
R
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|749544.3.peg.2880
Escherichia coli MS 175-1
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
F
R
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|340184.3.peg.4102
Escherichia coli B7A
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|340184.6.peg.4295
Escherichia coli B7A
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|656379.3.peg.3007
Escherichia coli FVEC1302
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|656380.3.peg.2508
Escherichia coli FVEC1412
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|679204.3.peg.1665
Escherichia coli MS 145-7
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|749549.3.peg.1380
Escherichia coli MS 198-1
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|656437.3.peg.2758
Escherichia coli TA143
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|585056.7.peg.2931
Escherichia coli UMN026
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|656393.3.peg.3450
Escherichia coli H299
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|670897.3.peg.3393
Escherichia coli 2362-75
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
P
T
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|550677.3.peg.2015
Escherichia coli B354
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
P
T
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|439855.10.peg.2742
Escherichia coli SMS-3-5
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
I
Q
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|216592.1.peg.5470
Escherichia coli 042
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
V
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|216592.3.peg.2760
Escherichia coli 042
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
V
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|562.371.peg.5297
Escherichia coli 1044A
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|562.373.peg.3623
Escherichia coli 1125A
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|562.372.peg.1846
Escherichia coli 1212A
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|562.374.peg.3048
Escherichia coli 536A
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|550676.3.peg.1629
Escherichia coli B185
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|656419.3.peg.3194
Escherichia coli M718
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|749531.3.peg.2680
Escherichia coli MS 69-1
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|83334.1.peg.3297
Escherichia coli O157:H7
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|155864.1.peg.3298
Escherichia coli O157:H7 EDL933
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|155864.8.peg.3203
Escherichia coli O157:H7 EDL933
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|444454.5.peg.2318
Escherichia coli O157:H7 str. EC4024
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|444449.5.peg.1784
Escherichia coli O157:H7 str. EC4042
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|444448.5.peg.538
Escherichia coli O157:H7 str. EC4045
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|444453.5.peg.20
Escherichia coli O157:H7 str. EC4076
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|444452.5.peg.1572
Escherichia coli O157:H7 str. EC4113
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|444451.5.peg.1342
Escherichia coli O157:H7 str. EC4196
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|444447.5.peg.678
Escherichia coli O157:H7 str. EC4206
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|478004.5.peg.2939
Escherichia coli O157:H7 str. EC4401
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|478005.5.peg.2508
Escherichia coli O157:H7 str. EC4486
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|478006.5.peg.1547
Escherichia coli O157:H7 str. EC4501
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|478007.5.peg.1592
Escherichia coli O157:H7 str. EC508
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|478008.5.peg.2982
Escherichia coli O157:H7 str. EC869
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|637388.3.peg.164
Escherichia coli O157:H7 str. FRIK2000
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|570506.3.peg.5168
Escherichia coli O157:H7 str. FRIK966
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|386585.9.peg.3447
Escherichia coli O157:H7 str. Sakai
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|544404.4.peg.3430
Escherichia coli O157:H7 str. TW14359
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|502346.5.peg.3986
Escherichia coli O157:H7 str. TW14588
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|701177.3.peg.2991
Escherichia coli O55:H7 str. CB9615
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|444450.8.peg.3627
Escherichia coli O157:H7 str. EC4115
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
D
TL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|656444.3.peg.3424
Escherichia coli TA280
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KA
R
QT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|749527.3.peg.4810
Escherichia coli MS 21-1
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
I
Q
D
A
A
EIA
A
Q
NK
R
Q
L
KA
R
QT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
P
T
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|216593.1.peg.2298
Escherichia coli E2348/69
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
P
T
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VR
H
F
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|358709.5.peg.2286
Escherichia coli 101-1
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SV
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|413997.3.peg.2435
Escherichia coli B str. REL606
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SV
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|511693.5.peg.2448
Escherichia coli BL21
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SV
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|469008.4.peg.1288
Escherichia coli BL21(DE3)
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SV
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|749547.3.peg.919
Escherichia coli MS 187-1
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
FGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SV
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPFI
T
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|585057.4.peg.2677
Escherichia coli IAI39
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
P
T
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLI
T
AW
A
C
A
R
IE
CM
V
H
RF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|585057.6.peg.2680
Escherichia coli IAI39
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
N
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KAKQT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
P
T
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLI
T
AW
A
C
A
R
IE
CM
V
H
RF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|585397.7.peg.2880
Escherichia coli ED1a
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KA
R
QT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
MVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
CM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
CG
FI
F
T
T
LFGCRNVNLD
fig|362663.8.peg.2476
Escherichia coli 536
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KA
R
QT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
CM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|362663.9.peg.2481
Escherichia coli 536
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KA
R
QT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
CM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|340197.3.peg.3016
Escherichia coli F11
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KA
R
QT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
CM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|340197.5.peg.3152
Escherichia coli F11
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KA
R
QT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
CM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|656417.3.peg.3111
Escherichia coli M605
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KA
R
QT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
CM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|749550.3.peg.5103
Escherichia coli MS 200-1
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KA
R
QT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
PA
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
CM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|562.376.peg.4346
Escherichia coli WV_060327
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
K
TR
QT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
P
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
P
T
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
CM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|405955.13.peg.2681
Escherichia coli APEC O1
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KA
R
QT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
T
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
P
T
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|405955.9.peg.2203
Escherichia coli APEC O1
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KA
R
QT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
T
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
P
T
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|714962.3.peg.2788
Escherichia coli IHE3034
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KA
R
QT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
T
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
P
T
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|585035.6.peg.2586
Escherichia coli S88
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KA
R
QT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
T
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
P
T
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|656440.3.peg.2485
Escherichia coli TA206
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KA
R
QT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
T
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
P
T
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|869729.3.peg.963
Escherichia coli UM146
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KA
R
QT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
T
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
P
T
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|364106.7.peg.2767
Escherichia coli UTI89
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KA
R
QT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
T
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
P
T
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|364106.8.peg.2767
Escherichia coli UTI89
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KA
R
QT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
T
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
P
T
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
GM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|525281.3.peg.4217
Escherichia coli 83972
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KA
R
QT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
T
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
P
T
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
CM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|655817.3.peg.2865
Escherichia coli ABU 83972
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KA
R
QT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
T
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
P
T
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
CM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|199310.1.peg.2887
Escherichia coli CFT073
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KA
R
QT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
T
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
P
T
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
CM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|199310.4.peg.2793
Escherichia coli CFT073
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KA
R
QT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
T
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
P
T
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
CM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|749546.3.peg.424
Escherichia coli MS 185-1
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KA
R
QT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
T
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
P
T
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
CM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|749528.3.peg.2324
Escherichia coli MS 45-1
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KA
R
QT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
T
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
P
T
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
CM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|753642.3.peg.2670
Escherichia coli NC101
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KA
R
QT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
T
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
P
T
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
CM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
EG
M
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|685038.3.peg.2473
Escherichia coli O83:H1 str. NRG 857C
MAKEISSEL
L
N
TILT
R
VGG
P
G
NIAS
CG
N
CMTRLRL
G
V
H
D
S
S
L
V
D
-
P
D
IKT
L
E
GVKGV
ILT
S
D
Q
V
QVVFG
P
G
KAH
R
A
A
K
A
M
S
E
L
L
G
E
AP
VQ
D
A
A
EIA
A
Q
NK
R
Q
L
KA
R
QT
S
G
V
Q
Q
F
L
A
K
F
AT
IFT
----
PLIP
GF
IA
A
GLLLG
IAT
LI
A
TVM
H
V
T
A
D
A
Q
GTL
P
DALNFM
K
V
F
S
K
GLF
T
FL
V
ILVGYNAA
QA
FGG
T
GV
N
GA
I
IA
A
L
FLLGYN
P
T
A
TT
GY
YA
G
F
H
-
-----
DFFG
L
PI
-
--D
P
R
G
NI
I
G
VLIAAW
A
C
A
R
IE
CM
VRRF
M
PD
D
LD
ML
LT
S
L
I
TLLITA
T
LA
Y
LII
M
PLG
G
WL
F
E
AM
S
-
------
---
-
WL
FMHLNSNP
LGC
AV
LA
GL
F
L
I
A
V
V
FGVH
Q
GFIP
V
YL
ALMD
S
Q
G
F
N
--------
S
L
F
PIL
S
MA
G
AG
QVGAALA
L
Y
W
RAQP
H
SA
LR
SQ
VR
G
A
I
I
P
G
-
LLG
V
G
EP
L
IYGV
T
LPR
M
KPF
VT
AC
L
GGA
A
GG
L
F
IG
L
I
A
WWGLP
M
GL
N
S
A
FG
PS
GL
-
V
ALP
L
M
T
SAQ
GIL
P
A
M
A
V
Y
A
-
-G
G
I
L
VA
W
V
SG
FI
F
T
T
LFGCRNVNLD
fig|749537.3.peg.3294
Escherichia coli MS 115-1 (5-446/456)
QIS
R
S
L
L
P
L
L
GG
K
E
NIAS
AA
HC
A
TRLRLV
L
V
DD
S
L
A
D
Q
Q
A
I
G
K
I
D
GVKG
CF
R
NA
G
Q
M
Q
I
I
FG
T
G
VV
N
K
V
Y
A
AF
I
Q
A
A
G
I
GE
-
SS
K
S
EAA
D
I
AA
K
KL
-----
N
P
F
QR
I
A
R
L
L
SN
IF
V
----
P
I
IPAI
V
A
S
GLL
M
GLL
G
M
V
-
KTY
G
W
V
DP
G
N
AI
Y
I
----
M
L
D
M
C
S
S
AA
F
I
I
LPIL
I
G
F
T
AA
RE
FGGN
PY
LGA
T
L
G
G
I
L
T
---
HPA
L
T
N
AW
--
G
V
AA
GFHTM
N
FFG
L
E
I
A
MIG
Y
Q
GTV
F
PVL
L
A
V
W
F
M
S
I
V
E
KQ
L
RR
V
I
PD
A
LD
LI
LTP
F
LT
V
I
I
S
GF
I
A
L
LIIGP
A
G
R
A
LG
D
GIS
FVLS
T
LIT
H
A
G
WL
--------
-AG
L
L
F
GGL
Y
S
V
I
V
I
T
G
I
H
H
S
F
HA
I
--
----
E
A
G
L
L
G
NPSIGVN
F
L
L
PI
W
A
MAN
VA
Q
G
GA
C
LAV
W
F
KTK
-
D
AK
I
K
AI
T
L
P
S
A
F
S
A
-
M
LGI
T
E
A
AI
F
G
I
N
L
R
FV
KPFIAA
L
IG
--
-
-
GA
V
G
G
A
W
V
-----
V
SM
H
VY
M
T
A
V
GL
-
TA
I
P
G
M
A
IV
Q
---
A
S
S
L
L
NY
-
II
GM
V
I
A
F
G
VA
F
V
VS
fig|656417.3.peg.3525
Escherichia coli M605 (5-449/456)
KI
A
Q
S
L
L
P
L
L
GG
K
E
NIAS
AA
HC
A
TRLRLV
L
V
DD
T
L
A
D
Q
H
A
I
GQ
I
D
GVKG
CF
R
N
S
G
Q
M
Q
I
I
FG
T
G
VV
N
K
V
Y
A
AF
I
Q
V
A
G
I
S
E
-
SS
K
A
DTA
R
L
AA
Q
KL
-----
N
P
F
QR
I
A
R
L
L
SN
IF
V
----
P
I
IPAI
V
A
S
GLL
M
GLL
G
M
V
-
KTY
G
W
V
NA
D
N
AI
Y
I
----
L
L
D
M
C
S
S
AA
F
I
I
LPIL
I
G
F
T
AA
RE
FGGN
PY
LGA
T
L
G
G
I
L
T
---
HPA
L
T
N
AW
--
G
V
AA
GFQTM
DFFG
FE
I
A
MIG
Y
Q
GTV
F
PVL
L
A
V
W
F
M
S
I
V
E
KQ
L
RRF
I
PD
A
LD
LI
LTP
F
LT
V
V
I
S
GF
I
A
L
LIIGP
A
G
R
A
LG
D
GIS
FVLS
T
LIA
H
A
G
WL
--------
-AG
L
L
F
GGL
Y
S
A
I
V
I
T
G
I
H
H
S
F
HA
I
--
----
E
A
G
L
L
G
NPAIGVN
F
L
L
PI
W
A
MAN
VA
Q
G
GA
C
LAV
W
F
KTK
-
D
TK
I
K
AI
T
L
P
S
A
F
S
A
-
M
LGI
T
E
A
AI
F
G
I
N
L
R
FV
KPFIAA
L
IG
--
-
-
GA
A
G
G
A
W
V
-----
V
SV
H
VY
M
T
A
V
GL
-
TA
I
P
G
M
A
IV
Q
---
P
T
S
L
V
NY
-
II
GM
V
I
A
F
A
VA
F
S
L
S
LL
L
fig|753642.3.peg.379
Escherichia coli NC101 (5-449/456)
KI
A
Q
S
L
L
P
L
L
GG
K
E
NIAS
AA
HC
A
TRLRLV
L
V
DD
T
L
A
D
Q
H
A
I
GQ
I
D
GVKG
CF
R
N
S
G
Q
M
Q
I
I
FG
T
G
VV
N
K
V
Y
A
AF
I
Q
V
A
G
I
S
E
-
SS
K
A
DTA
R
L
AA
Q
KL
-----
N
P
F
QR
I
A
R
L
L
SN
IF
V
----
P
I
IPAI
V
A
S
GLL
M
GLL
G
M
V
-
KTY
G
W
V
NA
D
N
AI
Y
I
----
L
L
D
M
C
S
S
AA
F
I
I
LPIL
I
G
F
T
AA
RE
FGGN
PY
LGA
T
L
G
G
I
L
T
---
HPA
L
T
N
AW
--
G
V
AA
GFQTM
N
FFG
FE
I
A
MIG
Y
Q
GT
I
F
PVL
L
A
V
W
F
M
S
I
V
E
KQ
L
RRF
I
PD
A
LD
LI
LTP
F
LT
V
V
I
S
GF
I
A
L
LIIGP
A
G
R
A
LG
D
GIS
FVLS
T
LIA
H
A
G
WL
--------
-AG
L
L
F
GGL
Y
S
A
I
V
I
T
G
I
H
H
S
F
HA
I
--
----
E
A
G
L
L
G
NPAIGVN
F
L
L
PI
W
A
MAN
VA
Q
G
GA
C
LAV
W
F
KTK
-
D
TK
I
K
AI
T
L
P
S
A
F
S
A
-
M
LGI
T
E
A
AI
F
G
I
N
L
R
FV
KPFIAA
L
IG
--
-
-
GA
A
G
G
A
W
V
-----
V
SV
H
VY
M
T
A
V
GL
-
TA
I
P
G
M
A
IV
Q
---
P
T
S
L
V
NY
-
II
GM
V
I
A
F
A
VA
F
S
L
S
LL
L
fig|749550.3.peg.730
Escherichia coli MS 200-1 (5-449/456)
KI
A
Q
S
L
L
P
L
L
GG
K
E
NIAS
AA
HC
A
TRLRLV
L
V
DD
T
L
A
D
Q
H
A
I
GQ
I
D
GVKG
CF
R
N
S
G
Q
M
Q
I
I
FG
T
G
VG
N
K
V
Y
A
AF
I
Q
V
A
G
I
S
E
-
SS
K
A
DTA
R
L
AA
Q
KL
-----
N
P
F
QR
I
A
R
L
L
SN
IF
V
----
P
I
IPAI
V
A
S
GLL
M
GLL
G
M
V
-
KTY
G
W
V
NA
D
N
AI
Y
I
----
L
L
D
M
C
S
S
AA
F
I
I
LPIL
I
G
F
T
AA
RE
FGGN
PY
LGA
T
L
G
G
I
L
T
---
HPA
L
T
N
AW
--
G
V
AA
GFQTM
N
FFG
FE
I
A
MIG
Y
Q
GTV
F
PVL
L
A
V
W
F
M
S
I
V
E
KQ
L
RRF
I
PD
A
LD
LI
LTP
F
LT
V
V
I
S
GF
I
A
L
LIIGP
A
G
R
A
LG
D
GIS
FVLS
T
LIA
H
A
G
WL
--------
-AG
L
L
F
GGL
Y
S
A
I
V
I
T
G
I
H
H
S
F
HA
I
--
----
E
A
G
L
L
G
NPAIGVN
F
L
L
PI
W
A
MAN
VA
Q
G
GA
C
LAV
W
F
KTK
-
D
TK
I
K
AI
T
L
P
S
A
F
S
A
-
M
LGI
T
E
A
AI
F
G
I
N
L
R
FV
KPFIAA
L
IG
--
-
-
GA
A
G
G
A
W
V
-----
V
SV
H
VY
M
T
A
V
GL
-
TA
I
P
G
M
A
IV
Q
---
P
T
S
L
V
NY
-
II
GM
V
I
A
F
A
VA
F
S
L
S
LL
L
fig|679205.4.peg.1056
Escherichia coli MS 124-1 (5-449/456)
KI
A
Q
S
L
L
P
L
L
GG
K
E
NIAS
AA
HC
A
TRLRLV
L
V
DD
T
L
A
D
Q
H
A
I
GQ
I
D
GVKG
CF
R
N
S
G
Q
M
Q
I
I
FG
T
G
VV
N
K
V
Y
A
AF
I
Q
V
A
G
I
S
E
-
SS
K
A
DIA
R
L
AA
Q
KL
-----
N
P
F
QR
I
A
R
L
L
SN
IF
V
----
P
I
IPAI
V
A
S
GLL
M
GLL
G
M
V
-
KTY
G
W
V
NT
D
N
AI
Y
I
----
L
L
D
M
C
S
S
AA
F
I
I
LPIL
I
G
F
T
AA
RE
FGGN
PY
LGA
T
L
G
G
I
L
T
---
HPA
L
T
N
AW
--
G
V
AA
GFQTM
N
FFG
FE
I
A
MIG
Y
Q
GTV
F
PVL
L
A
V
W
F
M
S
I
V
E
KQ
L
RRF
I
PD
A
LD
LI
LTP
F
LT
V
V
I
S
GF
I
A
L
LIIGP
A
G
R
A
LG
D
GIS
FVLS
T
LIA
H
A
G
WL
--------
-AG
L
L
F
GGL
Y
S
A
I
V
I
T
G
I
H
H
S
F
HA
I
--
----
E
A
G
L
L
G
NPAIGVN
F
L
L
PI
W
A
MAN
VA
Q
G
GA
C
LAV
W
F
KTK
-
D
TK
I
K
AI
T
L
P
S
A
F
S
A
-
M
LGI
T
E
A
AI
F
G
I
N
L
R
FV
KPFIAA
L
IG
--
-
-
GA
A
G
G
A
W
V
-----
V
SV
H
VY
M
T
A
V
GL
-
TA
I
P
G
M
A
IV
Q
---
P
T
S
L
V
NY
-
II
GM
V
I
A
F
A
VA
F
S
L
S
LLF
fig|749533.3.peg.3705
Escherichia coli MS 84-1 (5-449/456)
KI
A
Q
S
L
L
P
L
L
GG
K
E
NIAS
AA
HC
A
TRLRLV
L
V
DD
T
L
A
D
Q
H
A
I
GQ
I
D
GVKG
CF
R
N
S
G
Q
M
Q
I
I
FG
T
G
VV
N
K
V
Y
A
AF
I
Q
V
A
G
I
S
E
-
SS
K
A
DIA
R
L
AA
Q
KL
-----
N
P
F
QR
I
A
R
L
L
SN
IF
V
----
P
I
IPAI
V
A
S
GLL
M
GLL
G
M
V
-
KTY
G
W
V
NT
D
N
AI
Y
I
----
L
L
D
M
C
S
S
AA
F
I
I
LPIL
I
G
F
T
AA
RE
FGGN
PY
LGA
T
L
G
G
I
L
T
---
HPA
L
T
N
AW
--
G
V
AA
GFQTM
N
FFG
FE
I
A
MIG
Y
Q
GTV
F
PVL
L
A
V
W
F
M
S
I
V
E
KQ
L
RRF
I
PD
A
LD
LI
LTP
F
LT
V
V
I
S
GF
I
A
L
LIIGP
A
G
R
A
LG
D
GIS
FVLS
T
LIA
H
A
G
WL
--------
-AG
L
L
F
GGL
Y
S
A
I
V
I
T
G
I
H
H
S
F
HA
I
--
----
E
A
G
L
L
G
NPAIGVN
F
L
L
PI
W
A
MAN
VA
Q
G
GA
C
LAV
W
F
KTK
-
D
TK
I
K
AI
T
L
P
S
A
F
S
A
-
M
LGI
T
E
A
AI
F
G
I
N
L
R
FV
KPFIAA
L
IG
--
-
-
GA
A
G
G
A
W
V
-----
V
SV
H
VY
M
T
A
V
GL
-
TA
I
P
G
M
A
IV
Q
---
P
T
S
L
V
NY
-
II
GM
V
I
A
F
A
VA
F
S
L
S
LLF
fig|670897.3.peg.684
Escherichia coli 2362-75 (5-449/456)
KI
A
Q
S
L
L
P
L
L
GG
K
E
NIAS
AA
HC
A
TRLRLV
L
V
DD
T
L
A
D
Q
H
A
I
GQ
I
D
GVKG
CF
R
N
S
G
Q
M
Q
I
I
FG
T
G
VV
N
K
V
Y
A
AF
I
Q
V
A
G
I
S
E
-
SS
K
A
DTA
R
L
AA
Q
KL
-----
N
P
F
QR
I
A
R
L
L
SN
IF
V
----
P
I
IPAI
V
A
S
GLL
M
GLL
G
M
V
-
KTY
G
W
V
NA
D
N
AI
Y
I
----
L
L
D
M
C
S
S
AA
F
I
I
LPIL
I
G
F
T
AA
RE
FGGN
PY
LGA
T
L
G
G
I
L
T
---
HPA
L
T
N
AW
--
G
V
AA
GFQTM
N
FFG
FE
I
A
MIG
Y
Q
GTV
F
PVL
L
A
V
W
F
M
S
I
V
E
KQ
L
RRF
I
PD
A
LD
LI
LTP
F
LT
V
V
I
S
GF
I
A
L
LIIGP
A
G
R
A
LG
D
GIS
FVLS
T
LIA
H
A
G
WL
--------
-AG
L
L
F
GGL
Y
S
A
I
V
I
T
G
I
H
H
S
F
HA
I
--
----
E
A
G
L
L
G
NPAIGVN
F
L
L
PI
W
A
MAN
VA
Q
G
GA
C
LAV
W
F
KTK
-
D
TK
I
K
AI
T
L
P
S
A
F
S
A
-
M
LGI
T
E
A
AI
F
G
I
N
L
R
FV
KPFIAA
L
IG
--
-
-
GA
A
G
G
A
W
V
-----
V
SV
H
VY
M
T
A
V
GL
-
TA
I
P
G
M
A
IV
Q
---
P
T
S
L
V
NY
-
II
GM
V
I
A
F
A
VA
F
S
L
S
LL
L
fig|362663.8.peg.2786
Escherichia coli 536 (5-449/456)
KI
A
Q
S
L
L
P
L
L
GG
K
E
NIAS
AA
HC
A
TRLRLV
L
V
DD
T
L
A
D
Q
H
A
I
GQ
I
D
GVKG
CF
R
N
S
G
Q
M
Q
I
I
FG
T
G
VV
N
K
V
Y
A
AF
I
Q
V
A
G
I
S
E
-
SS
K
A
DTA
R
L
AA
Q
KL
-----
N
P
F
QR
I
A
R
L
L
SN
IF
V
----
P
I
IPAI
V
A
S
GLL
M
GLL
G
M
V
-
KTY
G
W
V
NA
D
N
AI
Y
I
----
L
L
D
M
C
S
S
AA
F
I
I
LPIL
I
G
F
T
AA
RE
FGGN
PY
LGA
T
L
G
G
I
L
T
---
HPA
L
T
N
AW
--
G
V
AA
GFQTM
N
FFG
FE
I
A
MIG
Y
Q
GTV
F
PVL
L
A
V
W
F
M
S
I
V
E
KQ
L
RRF
I
PD
A
LD
LI
LTP
F
LT
V
V
I
S
GF
I
A
L
LIIGP
A
G
R
A
LG
D
GIS
FVLS
T
LIA
H
A
G
WL
--------
-AG
L
L
F
GGL
Y
S
A
I
V
I
T
G
I
H
H
S
F
HA
I
--
----
E
A
G
L
L
G
NPAIGVN
F
L
L
PI
W
A
MAN
VA
Q
G
GA
C
LAV
W
F
KTK
-
D
TK
I
K
AI
T
L
P
S
A
F
S
A
-
M
LGI
T
E
A
AI
F
G
I
N
L
R
FV
KPFIAA
L
IG
--
-
-
GA
A
G
G
A
W
V
-----
V
SV
H
VY
M
T
A
V
GL
-
TA
I
P
G
M
A
IV
Q
---
P
T
S
L
V
NY
-
II
GM
V
I
A
F
A
VA
F
S
L
S
LL
L
fig|362663.9.peg.2792
Escherichia coli 536 (5-449/456)
KI
A
Q
S
L
L
P
L
L
GG
K
E
NIAS
AA
HC
A
TRLRLV
L
V
DD
T
L
A
D
Q
H
A
I
GQ
I
D
GVKG
CF
R
N
S
G
Q
M
Q
I
I
FG
T
G
VV
N
K
V
Y
A
AF
I
Q
V
A
G
I
S
E
-
SS
K
A
DTA
R
L
AA
Q
KL
-----
N
P
F
QR
I
A
R
L
L
SN
IF
V
----
P
I
IPAI
V
A
S
GLL
M
GLL
G
M
V
-
KTY
G
W
V
NA
D
N
AI
Y
I
----
L
L
D
M
C
S
S
AA
F
I
I
LPIL
I
G
F
T
AA
RE
FGGN
PY
LGA
T
L
G
G
I
L
T
---
HPA
L
T
N
AW
--
G
V
AA
GFQTM
N
FFG
FE
I
A
MIG
Y
Q
GTV
F
PVL
L
A
V
W
F
M
S
I
V
E
KQ
L
RRF
I
PD
A
LD
LI
LTP
F
LT
V
V
I
S
GF
I
A
L
LIIGP
A
G
R
A
LG
D
GIS
FVLS
T
LIA
H
A
G
WL
--------
-AG
L
L
F
GGL
Y
S
A
I
V
I
T
G
I
H
H
S
F
HA
I
--
----
E
A
G
L
L
G
NPAIGVN
F
L
L
PI
W
A
MAN
VA
Q
G
GA
C
LAV
W
F
KTK
-
D
TK
I
K
AI
T
L
P
S
A
F
S
A
-
M
LGI
T
E
A
AI
F
G
I
N
L
R
FV
KPFIAA
L
IG
--
-
-
GA
A
G
G
A
W
V
-----
V
SV
H
VY
M
T
A
V
GL
-
TA
I
P
G
M
A
IV
Q
---
P
T
S
L
V
NY
-
II
GM
V
I
A
F
A
VA
F
S
L
S
LL
L
fig|216593.1.peg.1231
Escherichia coli E2348/69 (5-449/456)
KI
A
Q
S
L
L
P
L
L
GG
K
E
NIAS
AA
HC
A
TRLRLV
L
V
DD
T
L
A
D
Q
H
A
I
GQ
I
D
GVKG
CF
R
N
S
G
Q
M
Q
I
I
FG
T
G
VV
N
K
V
Y
A
AF
I
Q
V
A
G
I
S
E
-
SS
K
A
DTA
R
L
AA
Q
KL
-----
N
P
F
QR
I
A
R
L
L
SN
IF
V
----
P
I
IPAI
V
A
S
GLL
M
GLL
G
M
V
-
KTY
G
W
V
NA
D
N
AI
Y
I
----
L
L
D
M
C
S
S
AA
F
I
I
LPIL
I
G
F
T
AA
RE
FGGN
PY
LGA
T
L
G
G
I
L
T
---
HPA
L
T
N
AW
--
G
V
AA
GFQTM
N
FFG
FE
I
A
MIG
Y
Q
GTV
F
PVL
L
A
V
W
F
M
S
I
V
E
KQ
L
RRF
I
PD
A
LD
LI
LTP
F
LT
V
V
I
S
GF
I
A
L
LIIGP
A
G
R
A
LG
D
GIS
FVLS
T
LIA
H
A
G
WL
--------
-AG
L
L
F
GGL
Y
S
A
I
V
I
T
G
I
H
H
S
F
HA
I
--
----
E
A
G
L
L
G
NPAIGVN
F
L
L
PI
W
A
MAN
VA
Q
G
GA
C
LAV
W
F
KTK
-
D
TK
I
K
AI
T
L
P
S
A
F
S
A
-
M
LGI
T
E
A
AI
F
G
I
N
L
R
FV
KPFIAA
L
IG
--
-
-
GA
A
G
G
A
W
V
-----
V
SV
H
VY
M
T
A
V
GL
-
TA
I
P
G
M
A
IV
Q
---
P
T
S
L
V
NY
-
II
GM
V
I
A
F
A
VA
F
S
L
S
LL
L
fig|340197.3.peg.1298
Escherichia coli F11 (5-449/456)
KI
A
Q
S
L
L
P
L
L
GG
K
E
NIAS
AA
HC
A
TRLRLV
L
V
DD
T
L
A
D
Q
H
A
I
GQ
I
D
GVKG
CF
R
N
S
G
Q
M
Q
I
I
FG
T
G
VV
N
K
V
Y
A
AF
I
Q
V
A
G
I
S
E
-
SS
K
A
DTA
R
L
AA
Q
KL
-----
N
P
F
QR
I
A
R
L
L
SN
IF
V
----
P
I
IPAI
V
A
S
GLL
M
GLL
G
M
V
-
KTY
G
W
V
NA
D
N
AI
Y
I
----
L
L
D
M
C
S
S
AA
F
I
I
LPIL
I
G
F
T
AA
RE
FGGN
PY
LGA
T
L
G
G
I
L
T
---
HPA
L
T
N
AW
--
G
V
AA
GFQTM
N
FFG
FE
I
A
MIG
Y
Q
GTV
F
PVL
L
A
V
W
F
M
S
I
V
E
KQ
L
RRF
I
PD
A
LD
LI
LTP
F
LT
V
V
I
S
GF
I
A
L
LIIGP
A
G
R
A
LG
D
GIS
FVLS
T
LIA
H
A
G
WL
--------
-AG
L
L
F
GGL
Y
S
A
I
V
I
T
G
I
H
H
S
F
HA
I
--
----
E
A
G
L
L
G
NPAIGVN
F
L
L
PI
W
A
MAN
VA
Q
G
GA
C
LAV
W
F
KTK
-
D
TK
I
K
AI
T
L
P
S
A
F
S
A
-
M
LGI
T
E
A
AI
F
G
I
N
L
R
FV
KPFIAA
L
IG
--
-
-
GA
A
G
G
A
W
V
-----
V
SV
H
VY
M
T
A
V
GL
-
TA
I
P
G
M
A
IV
Q
---
P
T
S
L
V
NY
-
II
GM
V
I
A
F
A
VA
F
S
L
S
LL
L
fig|340197.5.peg.1364
Escherichia coli F11 (5-449/456)
KI
A
Q
S
L
L
P
L
L
GG
K
E
NIAS
AA
HC
A
TRLRLV
L
V
DD
T
L
A
D
Q
H
A
I
GQ
I
D
GVKG
CF
R
N
S
G
Q
M
Q
I
I
FG
T
G
VV
N
K
V
Y
A
AF
I
Q
V
A
G
I
S
E
-
SS
K
A
DTA
R
L
AA
Q
KL
-----
N
P
F
QR
I
A
R
L
L
SN
IF
V
----
P
I
IPAI
V
A
S
GLL
M
GLL
G
M
V
-
KTY
G
W
V
NA
D
N
AI
Y
I
----
L
L
D
M
C
S
S
AA
F
I
I
LPIL
I
G
F
T
AA
RE
FGGN
PY
LGA
T
L
G
G
I
L
T
---
HPA
L
T
N
AW
--
G
V
AA
GFQTM
N
FFG
FE
I
A
MIG
Y
Q
GTV
F
PVL
L
A
V
W
F
M
S
I
V
E
KQ
L
RRF
I
PD
A
LD
LI
LTP
F
LT
V
V
I
S
GF
I
A
L
LIIGP
A
G
R
A
LG
D
GIS
FVLS
T
LIA
H
A
G
WL
--------
-AG
L
L
F
GGL
Y
S
A
I
V
I
T
G
I
H
H
S
F
HA
I
--
----
E
A
G
L
L
G
NPAIGVN
F
L
L
PI
W
A
MAN
VA
Q
G
GA
C
LAV
W
F
KTK
-
D
TK
I
K
AI
T
L
P
S
A
F
S
A
-
M
LGI
T
E
A
AI
F
G
I
N
L
R
FV
KPFIAA
L
IG
--
-
-
GA
A
G
G
A
W
V
-----
V
SV
H
VY
M
T
A
V
GL
-
TA
I
P
G
M
A
IV
Q
---
P
T
S
L
V
NY
-
II
GM
V
I
A
F
A
VA
F
S
L
S
LL
L
fig|574521.7.peg.3088
Escherichia coli O127:H6 str. E2348/69 (5-449/456)
KI
A
Q
S
L
L
P
L
L
GG
K
E
NIAS
AA
HC
A
TRLRLV
L
V
DD
T
L
A
D
Q
H
A
I
GQ
I
D
GVKG
CF
R
N
S
G
Q
M
Q
I
I
FG
T
G
VV
N
K
V
Y
A
AF
I
Q
V
A
G
I
S
E
-
SS
K
A
DTA
R
L
AA
Q
KL
-----
N
P
F
QR
I
A
R
L
L
SN
IF
V
----
P
I
IPAI
V
A
S
GLL
M
GLL
G
M
V
-
KTY
G
W
V
NA
D
N
AI
Y
I
----
L
L
D
M
C
S
S
AA
F
I
I
LPIL
I
G
F
T
AA
RE
FGGN
PY
LGA
T
L
G
G
I
L
T
---
HPA
L
T
N
AW
--
G
V
AA
GFQTM
N
FFG
FE
I
A
MIG
Y
Q
GTV
F
PVL
L
A
V
W
F
M
S
I
V
E
KQ
L
RRF
I
PD
A
LD
LI
LTP
F
LT
V
V
I
S
GF
I
A
L
LIIGP
A
G
R
A
LG
D
GIS
FVLS
T
LIA
H
A
G
WL
--------
-AG
L
L
F
GGL
Y
S
A
I
V
I
T
G
I
H
H
S
F
HA
I
--
----
E
A
G
L
L
G
NPAIGVN
F
L
L
PI
W
A
MAN
VA
Q
G
GA
C
LAV
W
F
KTK
-
D
TK
I
K
AI
T
L
P
S
A
F
S
A
-
M
LGI
T
E
A
AI
F
G
I
N
L
R
FV
KPFIAA
L
IG
--
-
-
GA
A
G
G
A
W
V
-----
V
SV
H
VY
M
T
A
V
GL
-
TA
I
P
G
M
A
IV
Q
---
P
T
S
L
V
NY
-
II
GM
V
I
A
F
A
VA
F
S
L
S
LL
L
fig|431946.3.peg.2687
Escherichia coli SE15 (5-449/456)
KI
A
Q
S
L
L
P
L
L
GG
K
E
NIAS
AA
HC
A
TRLRLV
L
V
DD
T
L
A
D
Q
H
A
I
GQ
I
D
GVKG
CF
R
N
S
G
Q
M
Q
I
I
FG
T
G
VV
N
K
V
Y
A
AF
I
Q
V
A
G
I
S
E
-
SS
K
A
DTA
R
L
AA
Q
KL
-----
N
P
F
QR
I
A
R
L
L
SN
IF
V
----
P
I
IPAI
V
A
S
GLL
M
GLL
G
M
V
-
KTY
G
W
V
NA
D
N
AI
Y
I
----
L
L
D
M
C
S
S
AA
F
I
I
LPIL
I
G
F
T
AA
RE
FGGN
PY
LGA
T
L
G
G
I
L
T
---
HPA
L
T
N
AW
--
G
V
AA
GFQTM
N
FFG
FE
I
A
MIG
Y
Q
GTV
F
PVL
L
A
V
W
F
M
S
I
V
E
KQ
L
RRF
I
PD
A
LD
LI
LTP
F
LT
V
V
I
S
GF
I
A
L
LIIGP
A
G
R
A
LG
D
GIS
FVLS
T
LIA
H
A
G
WL
--------
-AG
L
L
F
GGL
Y
S
A
I
V
I
T
G
I
H
H
S
F
HA
I
--
----
E
A
G
L
L
G
NPAIGVN
F
L
L
PI
W
A
MAN
VA
Q
G
GA
C
LAV
W
F
KTK
-
D
TK
I
K
AI
T
L
P
S
A
F
S
A
-
M
LGI
T
E
A
AI
F
G
I
N
L
R
FV
KPFIAA
L
IG
--
-
-
GA
A
G
G
A
W
V
-----
V
SV
H
VY
M
T
A
V
GL
-
TA
I
P
G
M
A
IV
Q
---
P
T
S
L
V
NY
-
II
GM
V
I
A
F
A
VA
F
S
L
S
LL
L
fig|439855.10.peg.3066
Escherichia coli SMS-3-5 (5-449/456)
KI
A
Q
S
L
L
P
L
L
GG
K
E
NIAS
AA
HC
A
TRLRLV
L
V
DD
T
L
A
D
Q
H
A
I
GQ
I
D
GVKG
CF
R
N
S
G
Q
M
Q
I
I
FG
T
G
VV
N
K
V
Y
A
AF
I
Q
V
A
G
I
S
E
-
SS
K
A
DTA
R
L
AA
Q
KL
-----
N
P
F
QR
I
A
R
L
L
SN
IF
V
----
P
I
IPAI
V
A
S
GLL
M
GLL
G
M
V
-
KTY
G
W
V
NA
D
N
AI
Y
I
----
L
L
D
M
C
S
S
AA
F
I
I
LPIL
I
G
F
T
AA
RE
FGGN
PY
LGA
T
L
G
G
I
L
T
---
HPA
L
T
N
AW
--
G
V
AA
GFQTM
N
FFG
FE
I
A
MIG
Y
Q
GTV
F
PVL
L
A
V
W
F
M
S
I
V
E
KQ
L
RRF
I
PD
A
LD
LI
LTP
F
LT
V
V
I
S
GF
I
A
L
LIIGP
A
G
R
A
LG
D
GIS
FVLS
T
LIA
H
A
G
WL
--------
-AG
L
L
F
GGL
Y
S
A
I
V
I
T
G
I
H
H
S
F
HA
I
--
----
E
A
G
L
L
G
NPAIGVN
F
L
L
PI
W
A
MAN
VA
Q
G
GA
C
LAV
W
F
KTK
-
D
TK
I
K
AI
T
L
P
S
A
F
S
A
-
M
LGI
T
E
A
AI
F
G
I
N
L
R
FV
KPFIAA
L
IG
--
-
-
GA
A
G
G
A
W
V
-----
V
SV
H
VY
M
T
A
V
GL
-
TA
I
P
G
M
A
IV
Q
---
P
T
S
L
V
NY
-
II
GM
V
I
A
F
A
VA
F
S
L
S
LL
L
fig|562.376.peg.3589
Escherichia coli WV_060327 (5-449/456)
KI
A
Q
S
L
L
P
L
L
GG
K
E
NIAS
AA
HC
A
TRLRLV
L
V
DD
T
L
A
D
Q
H
A
I
GQ
I
D
GVKG
CF
R
N
S
G
Q
M
Q
I
I
FG
T
G
VV
N
K
V
Y
A
AF
I
Q
V
A
G
I
S
E
-
SS
K
A
DTA
R
L
AA
Q
KL
-----
N
P
F
QR
I
A
R
L
L
SN
IF
V
----
P
I
IPAI
V
A
S
GLL
M
GLL
G
M
V
-
KTY
G
W
V
NA
D
N
AI
Y
I
----
L
L
D
M
C
S
S
AA
F
I
I
LPIL
I
G
F
T
AA
RE
FGGN
PY
LGA
T
L
G
G
I
L
T
---
HPA
L
T
N
AW
--
G
V
AA
GFQTM
N
FFG
FE
I
A
MIG
Y
Q
GTV
F
PVL
L
A
V
W
F
M
S
I
V
E
KQ
L
RRF
I
PD
A
LD
LI
LTP
F
LT
V
V
I
S
GF
I
A
L
LIIGP
A
G
R
A
LG
D
GIS
FVLS
T
LIA
H
A
G
WL
--------
-AG
L
L
F
GGL
Y
S
A
I
V
I
T
G
I
H
H
S
F
HA
I
--
----
E
A
G
L
L
G
NPAIGVN
F
L
L
PI
W
A
MAN
VA
Q
G
GA
C
LAV
W
F
KTK
-
D
TK
I
K
AI
T
L
P
S
A
F
S
A
-
M
LGI
T
E
A
AI
F
G
I
N
L
R
FV
KPFIAA
L
IG
--
-
-
GA
A
G
G
A
W
V
-----
V
SV
H
VY
M
T
A
V
GL
-
TA
I
P
G
M
A
IV
Q
---
P
T
S
L
V
NY
-
II
GM
V
I
A
F
A
VA
F
S
L
S
LL
L
fig|585057.4.peg.3070
Escherichia coli IAI39 (5-449/456)
KI
A
Q
S
L
L
P
L
L
GG
K
E
NI
T
S
AA
HC
A
TRLRLV
L
V
DD
T
L
A
D
Q
H
A
I
GQ
I
D
GVKG
CF
R
N
S
G
Q
M
Q
I
I
FG
T
G
VV
N
K
V
Y
A
AF
I
Q
V
A
G
I
S
E
-
SS
K
A
DTA
R
L
AA
Q
KL
-----
N
P
F
QR
I
A
R
L
L
SN
IF
V
----
P
I
IPAI
V
A
S
GLL
M
GLL
G
M
V
-
KTY
G
W
V
NA
D
N
AI
Y
I
----
L
L
D
M
C
S
S
AA
F
I
I
LPIL
I
G
F
T
AA
RE
FGGN
PY
LGA
T
L
G
G
I
L
T
---
HPA
L
T
N
AW
--
G
V
AA
GFQTM
N
FFG
FE
I
A
MIG
Y
Q
GTV
F
PVL
L
A
V
W
F
M
S
I
V
E
KQ
L
RRF
I
PD
A
LD
LI
LTP
F
LT
V
V
I
S
GF
I
A
L
LIIGP
A
G
R
A
LG
D
GIS
FVLS
T
LIA
H
A
G
WL
--------
-AG
L
L
F
GGL
Y
S
A
I
V
I
T
G
I
H
H
S
F
HA
I
--
----
E
A
G
L
L
G
NPAIGVN
F
L
L
PI
W
A
MAN
VA
Q
G
GA
C
LAV
W
F
KTK
-
D
TK
I
K
AI
T
L
P
S
A
F
S
A
-
M
LGI
T
E
A
AI
F
G
I
N
L
R
FV
KPFIAA
L
IG
--
-
-
GA
A
G
G
A
W
V
-----
V
SV
H
VY
M
T
A
V
GL
-
TA
I
P
G
M
A
IV
Q
---
P
T
S
L
V
NY
-
II
GM
V
I
A
F
A
VA
F
S
L
S
LL
L
fig|585057.6.peg.3076
Escherichia coli IAI39 (5-449/456)
KI
A
Q
S
L
L
P
L
L
GG
K
E
NI
T
S
AA
HC
A
TRLRLV
L
V
DD
T
L
A
D
Q
H
A
I
GQ
I
D
GVKG
CF
R
N
S
G
Q
M
Q
I
I
FG
T
G
VV
N
K
V
Y
A
AF
I
Q
V
A
G
I
S
E
-
SS
K
A
DTA
R
L
AA
Q
KL
-----
N
P
F
QR
I
A
R
L
L
SN
IF
V
----
P
I
IPAI
V
A
S
GLL
M
GLL
G
M
V
-
KTY
G
W
V
NA
D
N
AI
Y
I
----
L
L
D
M
C
S
S
AA
F
I
I
LPIL
I
G
F
T
AA
RE
FGGN
PY
LGA
T
L
G
G
I
L
T
---
HPA
L
T
N
AW
--
G
V
AA
GFQTM
N
FFG
FE
I
A
MIG
Y
Q
GTV
F
PVL
L
A
V
W
F
M
S
I
V
E
KQ
L
RRF
I
PD
A
LD
LI
LTP
F
LT
V
V
I
S
GF
I
A
L
LIIGP
A
G
R
A
LG
D
GIS
FVLS
T
LIA
H
A
G
WL
--------
-AG
L
L
F
GGL
Y
S
A
I
V
I
T
G
I
H
H
S
F
HA
I
--
----
E
A
G
L
L
G
NPAIGVN
F
L
L
PI
W
A
MAN
VA
Q
G
GA
C
LAV
W
F
KTK
-
D
TK
I
K
AI
T
L
P
S
A
F
S
A
-
M
LGI
T
E
A
AI
F
G
I
N
L
R
FV
KPFIAA
L
IG
--
-
-
GA
A
G
G
A
W
V
-----
V
SV
H
VY
M
T
A
V
GL
-
TA
I
P
G
M
A
IV
Q
---
P
T
S
L
V
NY
-
II
GM
V
I
A
F
A
VA
F
S
L
S
LL
L
fig|216593.1.peg.4533
Escherichia coli E2348/69 (8-458/633)
QV
M
T
ELA
R
TI
V
A
G
VGG
A
DNI
V
S
LM
HC
A
TRLR
F
K
L
KD
E
S
K
A
Q
A
E
V
L
K
K
T
P
G
I
IM
VV
E
S
G
G
Q
F
QVV
I
G
-
-
--
N
H
VA
D
V
F
L
A
V
N
S
V
A
G
L
G
E
K
A
QQA
P
E
N
D
D
K
G
-----
N
L
L
N
RF
V
Y
V
I
SG
IFT
----
PLI
GL
M
A
A
T
G
I
L
K
G
M
LAL
A
L
-TF
Q
W
T
T
E
Q
SGT
Y
L
----
IL
F
S
A
SD
A
LF
W
F
F
PI
I
L
GY
T
A
G
KR
F
S
GN
PF
T
A
M
V
I
G
G
A
LV
---
HP
L
I
L
T
AF
EN
G
Q
KV
DALGL
DF
L
GIP
V
T
LLN
Y
S
S
S
VIP
II
F
S
AW
L
CS
I
L
E
RR
L
NA
W
L
P
S
A
I
K
NF
F
TPLL
C
L
M
V
I
T
P
I
T
F
L
L
V
GPL
S
T
W
I
S
E
L
I
A
A
------
GYL
-
WL
YQAVSA
--
FAG
AVMGG
F
W
Q
I
F
VMFG
L
H
W
G
L
IP
L
II
NNFT
V
L
G
Y
D
--------
T
M
I
P
L
L
M
P
A
I
MA
QVGAAL
G
V
F
L
CE
R
-
D
AQ
KK
VV
A
G
S
AA
L
T
G
-
L
F
GI
T
EPA
V
YGV
N
LPRK
Y
PF
V
I
ACI
S
GA
L
G
AT
I
IG
Y
A
Q
-----
T
KV
Y
S
-
FG
L
PG
I
F
T
F
M
Q
T
I
P
S
T
G
---
I
D
F
T
VWA
S
VI
G
G
V
I
A
I
G
CA
F
V
G
T
VM
F
fig|574521.7.peg.4111
Escherichia coli O127:H6 str. E2348/69 (2-449/624)
T
ELA
R
TI
V
A
G
VGG
A
DNI
V
S
LM
HC
A
TRLR
F
K
L
KD
E
S
K
A
Q
A
E
V
L
K
K
T
P
G
I
IM
VV
E
S
G
G
Q
F
QVV
I
G
-
-
--
N
H
VA
D
V
F
L
A
V
N
S
V
A
G
L
G
E
K
A
QQA
P
E
N
D
D
K
G
-----
N
L
L
N
RF
V
Y
V
I
SG
IFT
----
PLI
GL
M
A
A
T
G
I
L
K
G
M
LAL
A
L
-TF
Q
W
T
T
E
Q
SGT
Y
L
----
IL
F
S
A
SD
A
LF
W
F
F
PI
I
L
GY
T
A
G
KR
F
S
GN
PF
T
A
M
V
I
G
G
A
LV
---
HP
L
I
L
T
AF
EN
G
Q
KV
DALGL
DF
L
GIP
V
T
LLN
Y
S
S
S
VIP
II
F
S
AW
L
CS
I
L
E
RR
L
NA
W
L
P
S
A
I
K
NF
F
TPLL
C
L
M
V
I
T
P
I
T
F
L
L
V
GPL
S
T
W
I
S
E
L
I
A
A
------
GYL
-
WL
YQAVSA
--
FAG
AVMGG
F
W
Q
I
F
VMFG
L
H
W
G
L
IP
L
II
NNFT
V
L
G
Y
D
--------
T
M
I
P
L
L
M
P
A
I
MA
QVGAAL
G
V
F
L
CE
R
-
D
AQ
KK
VV
A
G
S
AA
L
T
G
-
L
F
GI
T
EPA
V
YGV
N
LPRK
Y
PF
V
I
ACI
S
GA
L
G
AT
I
IG
Y
A
Q
-----
T
KV
Y
S
-
FG
L
PG
I
F
T
F
M
Q
T
I
P
S
T
G
---
I
D
F
T
VWA
S
VI
G
G
V
I
A
I
G
CA
F
V
G
T
VM
F
fig|685038.3.peg.3786
Escherichia coli O83:H1 str. NRG 857C (2-449/624)
T
ELA
R
TI
V
A
G
VGG
A
DNI
V
S
LM
HC
A
TRLR
F
K
L
KD
E
S
K
A
Q
A
E
V
L
K
K
T
P
G
I
IM
VV
E
S
G
G
Q
F
QVV
I
G
-
-
--
N
H
VA
D
V
F
L
A
V
N
S
V
A
G
L
G
E
K
A
QQA
P
E
N
D
D
K
D
-----
N
L
L
N
RF
V
Y
V
I
SG
IFT
----
PLI
GL
M
A
A
T
G
I
L
K
G
M
LAL
A
L
-TF
Q
W
A
T
E
Q
SGT
Y
L
----
IL
F
S
A
SD
A
LF
W
F
F
PI
I
L
GY
T
A
G
KR
FGGN
PF
T
A
M
V
I
G
G
A
LV
---
HP
L
I
L
T
AF
EN
G
Q
KV
DALGL
DF
L
GIP
V
T
LLN
Y
S
S
S
VIP
II
F
S
AW
L
CS
I
L
E
RR
L
NA
W
L
P
S
A
I
K
NF
F
TPLL
C
L
M
V
I
T
P
I
T
F
L
L
V
GPL
S
T
W
I
S
E
L
I
A
A
------
GYL
-
WL
YQAVPA
--
FAG
AVMGG
F
W
Q
I
F
VMFG
L
H
W
G
L
IP
L
II
NNFT
V
L
G
Y
D
--------
T
M
I
P
L
L
M
P
A
I
MA
QVGAAL
G
V
F
L
CE
R
-
D
AQ
KK
VV
A
G
S
AA
L
T
G
-
L
F
GI
T
EPA
V
YGV
N
LPRK
Y
PF
V
I
ACI
S
GA
L
G
AT
I
IG
Y
A
Q
-----
T
KV
Y
S
-
FG
L
PG
I
F
T
F
M
Q
T
I
P
S
T
G
---
I
D
F
T
VWA
S
VI
G
G
V
I
A
I
G
CA
F
V
G
T
VM
F
fig|585397.7.peg.4407
Escherichia coli ED1a (2-449/624)
T
ELA
R
TI
V
A
G
VGG
A
DNI
V
S
LM
HC
A
TRLR
F
K
L
KD
E
S
K
A
Q
A
E
V
L
K
K
T
P
G
I
IM
VV
E
S
G
G
Q
F
QVV
I
G
-
-
--
N
H
VA
D
V
F
L
A
V
N
S
V
A
G
L
G
E
K
A
QQA
P
E
N
D
D
K
G
-----
N
L
L
N
RF
V
Y
V
I
SG
IFT
----
PLI
GL
M
A
A
T
G
I
L
K
G
M
LAL
A
L
-TF
Q
W
T
T
E
Q
SGT
Y
L
----
IL
F
S
A
SD
A
LF
W
F
F
PI
I
L
GY
T
A
G
KR
F
S
GN
PF
T
A
M
V
I
G
G
A
LV
---
HP
L
I
L
T
AF
EN
G
Q
KV
DALGL
DF
L
GIP
V
T
LLN
Y
S
S
S
VIP
II
F
S
AW
L
CS
I
L
E
RR
L
NA
W
L
P
S
A
I
K
NF
F
TPLL
C
L
M
V
I
T
P
I
T
F
L
L
V
GPL
S
T
W
I
S
E
L
I
A
A
------
GYL
-
WL
YQAVPA
--
FAG
AVMGG
F
W
Q
I
F
VMFG
L
H
W
G
L
IP
L
II
NNFT
V
L
G
Y
D
--------
T
M
I
P
L
L
R
P
A
I
MA
QVGAAL
G
V
F
L
CE
R
-
D
AQ
KK
VV
A
G
S
AA
L
T
G
-
L
F
GI
T
EPA
V
YGV
N
LPRK
Y
PF
V
I
ACI
S
GA
L
G
AT
I
IG
Y
A
Q
-----
T
KV
Y
S
-
FG
L
PG
I
F
T
F
M
Q
T
I
P
S
T
G
---
I
D
F
T
VWA
S
VI
G
G
V
I
A
I
G
CA
F
V
G
T
VM
F
fig|585397.9.peg.4404
Escherichia coli ED1a (2-449/624)
T
ELA
R
TI
V
A
G
VGG
A
DNI
V
S
LM
HC
A
TRLR
F
K
L
KD
E
S
K
A
Q
A
E
V
L
K
K
T
P
G
I
IM
VV
E
S
G
G
Q
F
QVV
I
G
-
-
--
N
H
VA
D
V
F
L
A
V
N
S
V
A
G
L
G
E
K
A
QQA
P
E
N
D
D
K
G
-----
N
L
L
N
RF
V
Y
V
I
SG
IFT
----
PLI
GL
M
A
A
T
G
I
L
K
G
M
LAL
A
L
-TF
Q
W
T
T
E
Q
SGT
Y
L
----
IL
F
S
A
SD
A
LF
W
F
F
PI
I
L
GY
T
A
G
KR
F
S
GN
PF
T
A
M
V
I
G
G
A
LV
---
HP
L
I
L
T
AF
EN
G
Q
KV
DALGL
DF
L
GIP
V
T
LLN
Y
S
S
S
VIP
II
F
S
AW
L
CS
I
L
E
RR
L
NA
W
L
P
S
A
I
K
NF
F
TPLL
C
L
M
V
I
T
P
I
T
F
L
L
V
GPL
S
T
W
I
S
E
L
I
A
A
------
GYL
-
WL
YQAVPA
--
FAG
AVMGG
F
W
Q
I
F
VMFG
L
H
W
G
L
IP
L
II
NNFT
V
L
G
Y
D
--------
T
M
I
P
L
L
R
P
A
I
MA
QVGAAL
G
V
F
L
CE
R
-
D
AQ
KK
VV
A
G
S
AA
L
T
G
-
L
F
GI
T
EPA
V
YGV
N
LPRK
Y
PF
V
I
ACI
S
GA
L
G
AT
I
IG
Y
A
Q
-----
T
KV
Y
S
-
FG
L
PG
I
F
T
F
M
Q
T
I
P
S
T
G
---
I
D
F
T
VWA
S
VI
G
G
V
I
A
I
G
CA
F
V
G
T
VM
F
fig|753642.3.peg.4199
Escherichia coli NC101 (2-449/624)
T
ELA
R
TI
V
A
G
VGG
A
DNI
V
S
LM
HC
A
TRLR
F
K
L
KD
E
S
K
A
Q
A
E
V
L
K
K
T
P
G
I
IM
VV
E
S
G
G
Q
F
QVV
I
G
-
-
--
N
H
VA
D
V
F
L
A
V
N
S
V
A
G
L
G
E
K
A
QQA
P
E
N
D
D
K
D
-----
N
L
L
N
RF
V
Y
V
I
SG
IFT
----
PLI
GL
M
A
A
T
G
I
L
K
G
M
LAL
A
L
-TF
Q
W
T
T
E
Q
SGT
Y
L
----
IL
F
S
A
SD
A
LF
W
F
F
PI
I
L
GY
T
A
G
KR
FGGN
PF
T
A
M
V
I
G
G
A
LV
---
HP
L
I
L
T
AF
EN
G
Q
KV
DALGL
DF
L
GIP
V
T
LLN
Y
S
S
S
VIP
II
F
S
AW
L
CS
I
L
E
RR
L
NA
W
L
P
S
A
I
K
NF
F
TPLL
C
L
M
V
I
T
P
I
T
F
L
L
V
GPL
S
T
W
I
S
E
L
I
A
A
------
GYL
-
WL
YQAVPA
--
FAG
AVMGG
F
W
Q
I
F
VMFG
L
H
W
G
L
IP
L
II
NNFT
V
L
G
Y
D
--------
T
M
I
P
L
L
M
P
A
I
MA
QVGAAL
G
V
F
L
CE
R
-
D
AQ
KK
VV
A
G
S
AA
L
T
G
-
L
F
GI
T
EPA
V
YGV
N
LPRK
Y
PF
V
I
ACI
S
GA
L
G
AT
I
IG
Y
A
Q
-----
T
KV
Y
S
-
FG
L
PG
I
F
T
F
M
Q
T
I
P
S
T
G
---
I
D
F
T
VWA
S
VI
G
G
V
I
A
I
G
CA
F
V
G
T
VM
L
fig|405955.9.peg.3495
Escherichia coli APEC O1 (24-474/649)
QV
M
T
ELA
R
TI
V
A
G
VGG
A
DNI
V
S
LM
HC
A
TRLR
F
K
L
KD
E
S
K
A
Q
A
E
V
L
K
K
T
P
G
I
IM
VV
E
S
G
G
Q
F
QVV
I
G
-
-
--
N
H
VA
D
V
F
L
A
V
N
S
V
A
G
L
G
E
K
A
QQA
P
E
N
D
D
K
D
-----
N
L
L
N
RF
F
Y
V
I
SG
IFT
----
PLI
GL
M
A
A
T
G
I
L
K
G
M
LAL
A
L
-TF
Q
W
A
T
E
Q
SGT
Y
L
----
IL
F
S
A
SD
A
LF
W
F
F
PI
I
L
GY
T
A
G
KR
F
S
GN
PF
T
A
M
V
I
G
G
A
LV
---
HP
L
I
L
T
AF
EN
G
Q
KV
DALGL
DF
L
GIP
V
T
LLN
Y
S
S
S
VIP
II
F
S
AW
L
CS
I
L
E
RR
L
NT
W
L
P
S
A
I
K
NF
F
TPLL
C
L
M
V
I
T
P
I
T
F
L
L
V
GPL
S
T
W
I
S
E
L
I
A
A
------
GYL
-
WL
YQAVPA
--
FAG
AVMGG
F
W
Q
I
F
VMFG
L
H
W
G
L
IP
L
II
NNFT
V
L
G
Y
D
--------
T
M
I
P
L
L
M
P
A
I
MA
QVGAAL
G
V
F
L
CE
R
-
D
AQ
KK
VV
A
G
S
AA
L
T
G
-
L
F
GI
T
EPA
V
YGV
N
LPRK
Y
PF
V
I
ACI
S
GA
L
G
AT
I
IG
Y
A
Q
-----
T
KV
Y
S
-
FG
L
PG
I
F
T
F
M
Q
T
I
P
S
T
G
---
I
D
F
T
VWA
S
VI
G
G
V
I
A
I
G
CA
F
V
G
T
VM
F
fig|670897.3.peg.3541
Escherichia coli 2362-75 (2-449/624)
T
ELA
R
TI
V
A
G
VGG
A
DNI
V
S
LM
HC
A
TRLR
F
K
L
KD
E
S
K
A
Q
A
E
V
L
K
K
T
P
G
I
IM
VV
E
S
G
G
Q
F
QVV
I
G
-
-
--
N
H
VA
D
V
F
L
A
V
N
S
V
A
G
L
G
E
K
A
QQA
P
E
N
D
D
K
G
-----
N
L
L
N
RF
V
Y
V
I
SG
IFT
----
PLI
GL
M
A
A
T
G
I
L
K
G
M
LAL
A
L
-TF
Q
W
T
T
E
Q
SGT
Y
L
----
IL
F
S
A
SD
A
LF
W
F
F
PI
I
L
GY
T
A
G
KR
F
S
GN
PF
T
A
M
V
I
G
G
A
LV
---
HP
L
I
L
T
AF
EN
G
Q
KV
DALGL
DF
L
GIP
V
T
LLN
Y
S
S
S
VIP
II
F
S
AW
L
CS
I
L
E
RR
L
NA
W
L
P
S
A
I
K
NF
F
TPLL
C
L
M
V
I
T
P
I
T
F
L
L
V
GPL
S
T
W
I
S
E
L
I
A
A
------
GYL
-
WL
YQAVPA
--
FAG
AVMGG
F
W
Q
I
F
VMFG
L
H
W
G
L
IP
L
II
NNFT
V
L
G
Y
D
--------
T
M
I
P
L
L
M
P
A
I
MA
QVGAAL
G
V
F
L
CE
R
-
D
AQ
KK
VV
A
G
S
AA
L
T
G
-
L
F
GI
T
EPA
V
YGV
N
LPRK
Y
PF
V
I
ACI
S
GA
L
G
AT
I
IG
Y
A
Q
-----
T
KV
Y
S
-
FG
L
PG
I
F
T
F
M
Q
T
I
P
S
T
G
---
I
D
F
T
VWA
S
VI
G
G
V
I
A
I
G
CA
F
V
G
T
VM
F
fig|340197.3.peg.431
Escherichia coli F11 (2-449/624)
T
ELA
R
TI
V
A
G
VGG
A
DNI
V
S
LM
HC
A
TRLR
F
K
L
KD
E
S
K
A
Q
A
E
V
L
K
K
T
P
G
I
IM
VV
E
S
G
G
Q
F
QVV
I
G
-
-
--
N
H
VA
D
V
F
L
A
V
N
S
V
A
G
L
G
E
K
A
QQA
P
E
N
D
D
K
G
-----
N
L
L
N
RF
V
Y
V
I
SG
IFT
----
PLI
GL
M
A
A
T
G
I
L
K
G
M
LAL
A
L
-TF
Q
W
T
T
E
Q
SGT
Y
L
----
IL
F
S
A
SD
A
LF
W
F
F
PI
I
L
GY
T
A
G
KR
F
S
GN
PF
T
A
M
V
I
G
G
A
LV
---
HP
L
I
L
T
AF
EN
G
Q
KV
DALGL
DF
L
GIP
V
T
LLN
Y
S
S
S
VIP
II
F
S
AW
L
CS
I
L
E
RR
L
NA
W
L
P
S
A
I
K
NF
F
TPLL
C
L
M
V
I
T
P
I
T
F
L
L
V
GPL
S
T
W
I
S
E
L
I
A
A
------
GYL
-
WL
YQAVPA
--
FAG
AVMGG
F
W
Q
I
F
VMFG
L
H
W
G
L
IP
L
II
NNFT
V
L
G
Y
D
--------
T
M
I
P
L
L
M
P
A
I
MA
QVGAAL
G
V
F
L
CE
R
-
D
AQ
KK
VV
A
G
S
AA
L
T
G
-
L
F
GI
T
EPA
V
YGV
N
LPRK
Y
PF
V
I
ACI
S
GA
L
G
AT
I
IG
Y
A
Q
-----
T
KV
Y
S
-
FG
L
PG
I
F
T
F
M
Q
T
I
P
S
T
G
---
I
D
F
T
VWA
S
VI
G
G
V
I
A
I
G
CA
F
V
G
T
VM
F
fig|340197.5.peg.443
Escherichia coli F11 (2-449/624)
T
ELA
R
TI
V
A
G
VGG
A
DNI
V
S
LM
HC
A
TRLR
F
K
L
KD
E
S
K
A
Q
A
E
V
L
K
K
T
P
G
I
IM
VV
E
S
G
G
Q
F
QVV
I
G
-
-
--
N
H
VA
D
V
F
L
A
V
N
S
V
A
G
L
G
E
K
A
QQA
P
E
N
D
D
K
G
-----
N
L
L
N
RF
V
Y
V
I
SG
IFT
----
PLI
GL
M
A
A
T
G
I
L
K
G
M
LAL
A
L
-TF
Q
W
T
T
E
Q
SGT
Y
L
----
IL
F
S
A
SD
A
LF
W
F
F
PI
I
L
GY
T
A
G
KR
F
S
GN
PF
T
A
M
V
I
G
G
A
LV
---
HP
L
I
L
T
AF
EN
G
Q
KV
DALGL
DF
L
GIP
V
T
LLN
Y
S
S
S
VIP
II
F
S
AW
L
CS
I
L
E
RR
L
NA
W
L
P
S
A
I
K
NF
F
TPLL
C
L
M
V
I
T
P
I
T
F
L
L
V
GPL
S
T
W
I
S
E
L
I
A
A
------
GYL
-
WL
YQAVPA
--
FAG
AVMGG
F
W
Q
I
F
VMFG
L
H
W
G
L
IP
L
II
NNFT
V
L
G
Y
D
--------
T
M
I
P
L
L
M
P
A
I
MA
QVGAAL
G
V
F
L
CE
R
-
D
AQ
KK
VV
A
G
S
AA
L
T
G
-
L
F
GI
T
EPA
V
YGV
N
LPRK
Y
PF
V
I
ACI
S
GA
L
G
AT
I
IG
Y
A
Q
-----
T
KV
Y
S
-
FG
L
PG
I
F
T
F
M
Q
T
I
P
S
T
G
---
I
D
F
T
VWA
S
VI
G
G
V
I
A
I
G
CA
F
V
G
T
VM
F
fig|749550.3.peg.2382
Escherichia coli MS 200-1 (2-449/624)
T
ELA
R
TI
V
A
G
VGG
A
DNI
V
S
LM
HC
A
TRLR
F
K
L
KD
E
S
K
A
Q
A
E
V
L
K
K
T
P
G
I
IM
VV
E
S
G
G
Q
F
QVV
I
G
-
-
--
N
H
VA
D
V
F
L
A
V
N
S
V
A
G
L
G
E
K
A
QQA
P
E
N
D
D
K
G
-----
N
L
L
N
RF
V
Y
V
I
SG
IFT
----
PLI
GL
M
A
A
T
G
I
L
K
G
M
LAL
A
L
-TF
Q
W
T
T
E
Q
SGT
Y
L
----
IL
F
S
A
SD
A
LF
W
F
F
PI
I
L
GY
T
A
G
KR
F
S
GN
PF
T
A
M
V
I
G
G
A
LV
---
HP
L
I
L
T
AF
EN
G
Q
KV
DALGL
DF
L
GIP
V
T
LLN
Y
S
S
S
VIP
II
F
S
AW
L
CS
I
L
E
RR
L
NA
W
L
P
S
A
I
K
NF
F
TPLL
C
L
M
V
I
T
P
I
T
F
L
L
V
GPL
S
T
W
I
S
E
L
I
A
A
------
GYL
-
WL
YQAVPA
--
FAG
AVMGG
F
W
Q
I
F
VMFG
L
H
W
G
L
IP
L
II
NNFT
V
L
G
Y
D
--------
T
M
I
P
L
L
M
P
A
I
MA
QVGAAL
G
V
F
L
CE
R
-
D
AQ
KK
VV
A
G
S
AA
L
T
G
-
L
F
GI
T
EPA
V
YGV
N
LPRK
Y
PF
V
I
ACI
S
GA
L
G
AT
I
IG
Y
A
Q
-----
T
KV
Y
S
-
FG
L
PG
I
F
T
F
M
Q
T
I
P
S
T
G
---
I
D
F
T
VWA
S
VI
G
G
V
I
A
I
G
CA
F
V
G
T
VM
F
fig|199310.1.peg.4545
Escherichia coli CFT073 (24-474/649)
QV
M
T
ELA
R
TI
V
A
G
VGG
A
DNI
V
S
LM
HC
A
TRLR
F
K
L
KD
E
S
K
A
Q
A
E
V
L
K
K
T
P
G
I
IM
VV
E
S
G
G
Q
F
QVV
I
G
-
-
--
N
H
VA
D
V
F
L
A
V
N
S
V
A
G
L
G
E
K
A
QQA
P
E
N
D
D
K
G
-----
N
L
L
N
RF
V
Y
V
I
SG
IFT
----
PLI
GL
M
A
A
T
G
I
L
K
G
M
LAL
A
L
-TF
Q
W
T
T
E
Q
SGT
Y
L
----
IL
F
S
A
SD
A
LF
W
F
F
PI
I
L
GY
T
A
G
KR
F
S
GN
PF
T
A
M
V
I
G
G
A
LV
---
HP
L
I
L
T
AF
EN
G
Q
KV
DALGL
DF
L
GIP
V
T
LLN
Y
S
S
S
VIP
II
F
S
AW
L
CS
I
L
E
RR
L
NA
W
L
P
S
A
I
K
NF
F
TPLL
C
L
M
V
I
T
P
I
T
F
L
L
V
GPL
S
T
W
I
S
E
L
I
A
A
------
GYL
-
WL
YQAVPA
--
FAG
AVMGG
F
W
Q
I
F
VMFG
L
H
W
G
L
IP
L
II
NNFT
V
L
G
Y
D
--------
T
M
I
P
L
L
M
P
A
I
MA
QVGAAL
G
V
F
L
CE
R
-
D
AQ
KK
VV
A
G
S
AA
L
T
G
-
L
F
GI
T
EPA
V
YGV
N
LPRK
Y
PF
V
I
ACI
S
GA
L
G
AT
I
IG
Y
A
Q
-----
T
KV
Y
S
-
FG
L
PG
I
F
T
F
M
Q
T
I
P
S
T
G
---
I
D
F
T
VWA
S
VI
G
G
V
I
A
I
G
CA
F
V
G
T
VM
L
fig|405955.13.peg.4177
Escherichia coli APEC O1 (2-449/624)
T
ELA
R
TI
V
A
G
VGG
A
DNI
V
S
LM
HC
A
TRLR
F
K
L
KD
E
S
K
A
Q
A
E
V
L
K
K
T
P
G
I
IM
VV
E
S
G
G
Q
F
QVV
I
G
-
-
--
N
H
VA
D
V
F
L
A
V
N
S
V
A
G
L
G
E
K
A
QQA
P
E
N
D
D
K
D
-----
N
L
L
N
RF
F
Y
V
I
SG
IFT
----
PLI
GL
M
A
A
T
G
I
L
K
G
M
LAL
A
L
-TF
Q
W
A
T
E
Q
SGT
Y
L
----
IL
F
S
A
SD
A
LF
W
F
F
PI
I
L
GY
T
A
G
KR
F
S
GN
PF
T
A
M
V
I
G
G
A
LV
---
HP
L
I
L
T
AF
EN
G
Q
KV
DALGL
DF
L
GIP
V
T
LLN
Y
S
S
S
VIP
II
F
S
AW
L
CS
I
L
E
RR
L
NT
W
L
P
S
A
I
K
NF
F
TPLL
C
L
M
V
I
T
P
I
T
F
L
L
V
GPL
S
T
W
I
S
E
L
I
A
A
------
GYL
-
WL
YQAVPA
--
FAG
AVMGG
F
W
Q
I
F
VMFG
L
H
W
G
L
IP
L
II
NNFT
V
L
G
Y
D
--------
T
M
I
P
L
L
M
P
A
I
MA
QVGAAL
G
V
F
L
CE
R
-
D
AQ
KK
VV
A
G
S
AA
L
T
G
-
L
F
GI
T
EPA
V
YGV
N
LPRK
Y
PF
V
I
ACI
S
GA
L
G
AT
I
IG
Y
A
Q
-----
T
KV
Y
S
-
FG
L
PG
I
F
T
F
M
Q
T
I
P
S
T
G
---
I
D
F
T
VWA
S
VI
G
G
V
I
A
I
G
CA
F
V
G
T
VM
F
fig|714962.3.peg.4213
Escherichia coli IHE3034 (2-449/624)
T
ELA
R
TI
V
A
G
VGG
A
DNI
V
S
LM
HC
A
TRLR
F
K
L
KD
E
S
K
A
Q
A
E
V
L
K
K
T
P
G
I
IM
VV
E
S
G
G
Q
F
QVV
I
G
-
-
--
N
H
VA
D
V
F
L
A
V
N
S
V
A
G
L
G
E
K
A
QQA
P
E
N
D
D
K
D
-----
N
L
L
N
RF
F
Y
V
I
SG
IFT
----
PLI
GL
M
A
A
T
G
I
L
K
G
M
LAL
A
L
-TF
Q
W
A
T
E
Q
SGT
Y
L
----
IL
F
S
A
SD
A
LF
W
F
F
PI
I
L
GY
T
A
G
KR
F
S
GN
PF
T
A
M
V
I
G
G
A
LV
---
HP
L
I
L
T
AF
EN
G
Q
KV
DALGL
DF
L
GIP
V
T
LLN
Y
S
S
S
VIP
II
F
S
AW
L
CS
I
L
E
RR
L
NT
W
L
P
S
A
I
K
NF
F
TPLL
C
L
M
V
I
T
P
I
T
F
L
L
V
GPL
S
T
W
I
S
E
L
I
A
A
------
GYL
-
WL
YQAVPA
--
FAG
AVMGG
F
W
Q
I
F
VMFG
L
H
W
G
L
IP
L
II
NNFT
V
L
G
Y
D
--------
T
M
I
P
L
L
M
P
A
I
MA
QVGAAL
G
V
F
L
CE
R
-
D
AQ
KK
VV
A
G
S
AA
L
T
G
-
L
F
GI
T
EPA
V
YGV
N
LPRK
Y
PF
V
I
ACI
S
GA
L
G
AT
I
IG
Y
A
Q
-----
T
KV
Y
S
-
FG
L
PG
I
F
T
F
M
Q
T
I
P
S
T
G
---
I
D
F
T
VWA
S
VI
G
G
V
I
A
I
G
CA
F
V
G
T
VM
F
fig|585035.6.peg.4074
Escherichia coli S88 (2-449/624)
T
ELA
R
TI
V
A
G
VGG
A
DNI
V
S
LM
HC
A
TRLR
F
K
L
KD
E
S
K
A
Q
A
E
V
L
K
K
T
P
G
I
IM
VV
E
S
G
G
Q
F
QVV
I
G
-
-
--
N
H
VA
D
V
F
L
A
V
N
S
V
A
G
L
G
E
K
A
QQA
P
E
N
D
D
K
D
-----
N
L
L
N
RF
F
Y
V
I
SG
IFT
----
PLI
GL
M
A
A
T
G
I
L
K
G
M
LAL
A
L
-TF
Q
W
A
T
E
Q
SGT
Y
L
----
IL
F
S
A
SD
A
LF
W
F
F
PI
I
L
GY
T
A
G
KR
F
S
GN
PF
T
A
M
V
I
G
G
A
LV
---
HP
L
I
L
T
AF
EN
G
Q
KV
DALGL
DF
L
GIP
V
T
LLN
Y
S
S
S
VIP
II
F
S
AW
L
CS
I
L
E
RR
L
NT
W
L
P
S
A
I
K
NF
F
TPLL
C
L
M
V
I
T
P
I
T
F
L
L
V
GPL
S
T
W
I
S
E
L
I
A
A
------
GYL
-
WL
YQAVPA
--
FAG
AVMGG
F
W
Q
I
F
VMFG
L
H
W
G
L
IP
L
II
NNFT
V
L
G
Y
D
--------
T
M
I
P
L
L
M
P
A
I
MA
QVGAAL
G
V
F
L
CE
R
-
D
AQ
KK
VV
A
G
S
AA
L
T
G
-
L
F
GI
T
EPA
V
YGV
N
LPRK
Y
PF
V
I
ACI
S
GA
L
G
AT
I
IG
Y
A
Q
-----
T
KV
Y
S
-
FG
L
PG
I
F
T
F
M
Q
T
I
P
S
T
G
---
I
D
F
T
VWA
S
VI
G
G
V
I
A
I
G
CA
F
V
G
T
VM
F
fig|869729.3.peg.4032
Escherichia coli UM146 (2-449/624)
T
ELA
R
TI
V
A
G
VGG
A
DNI
V
S
LM
HC
A
TRLR
F
K
L
KD
E
S
K
A
Q
A
E
V
L
K
K
T
P
G
I
IM
VV
E
S
G
G
Q
F
QVV
I
G
-
-
--
N
H
VA
D
V
F
L
A
V
N
S
V
A
G
L
G
E
K
A
QQA
P
E
N
D
D
K
D
-----
N
L
L
N
RF
F
Y
V
I
SG
IFT
----
PLI
GL
M
A
A
T
G
I
L
K
G
M
LAL
A
L
-TF
Q
W
A
T
E
Q
SGT
Y
L
----
IL
F
S
A
SD
A
LF
W
F
F
PI
I
L
GY
T
A
G
KR
F
S
GN
PF
T
A
M
V
I
G
G
A
LV
---
HP
L
I
L
T
AF
EN
G
Q
KV
DALGL
DF
L
GIP
V
T
LLN
Y
S
S
S
VIP
II
F
S
AW
L
CS
I
L
E
RR
L
NT
W
L
P
S
A
I
K
NF
F
TPLL
C
L
M
V
I
T
P
I
T
F
L
L
V
GPL
S
T
W
I
S
E
L
I
A
A
------
GYL
-
WL
YQAVPA
--
FAG
AVMGG
F
W
Q
I
F
VMFG
L
H
W
G
L
IP
L
II
NNFT
V
L
G
Y
D
--------
T
M
I
P
L
L
M
P
A
I
MA
QVGAAL
G
V
F
L
CE
R
-
D
AQ
KK
VV
A
G
S
AA
L
T
G
-
L
F
GI
T
EPA
V
YGV
N
LPRK
Y
PF
V
I
ACI
S
GA
L
G
AT
I
IG
Y
A
Q
-----
T
KV
Y
S
-
FG
L
PG
I
F
T
F
M
Q
T
I
P
S
T
G
---
I
D
F
T
VWA
S
VI
G
G
V
I
A
I
G
CA
F
V
G
T
VM
F
fig|364106.7.peg.4180
Escherichia coli UTI89 (2-449/624)
T
ELA
R
TI
V
A
G
VGG
A
DNI
V
S
LM
HC
A
TRLR
F
K
L
KD
E
S
K
A
Q
A
E
V
L
K
K
T
P
G
I
IM
VV
E
S
G
G
Q
F
QVV
I
G
-
-
--
N
H
VA
D
V
F
L
A
V
N
S
V
A
G
L
G
E
K
A
QQA
P
E
N
D
D
K
D
-----
N
L
L
N
RF
F
Y
V
I
SG
IFT
----
PLI
GL
M
A
A
T
G
I
L
K
G
M
LAL
A
L
-TF
Q
W
A
T
E
Q
SGT
Y
L
----
IL
F
S
A
SD
A
LF
W
F
F
PI
I
L
GY
T
A
G
KR
F
S
GN
PF
T
A
M
V
I
G
G
A
LV
---
HP
L
I
L
T
AF
EN
G
Q
KV
DALGL
DF
L
GIP
V
T
LLN
Y
S
S
S
VIP
II
F
S
AW
L
CS
I
L
E
RR
L
NT
W
L
P
S
A
I
K
NF
F
TPLL
C
L
M
V
I
T
P
I
T
F
L
L
V
GPL
S
T
W
I
S
E
L
I
A
A
------
GYL
-
WL
YQAVPA
--
FAG
AVMGG
F
W
Q
I
F
VMFG
L
H
W
G
L
IP
L
II
NNFT
V
L
G
Y
D
--------
T
M
I
P
L
L
M
P
A
I
MA
QVGAAL
G
V
F
L
CE
R
-
D
AQ
KK
VV
A
G
S
AA
L
T
G
-
L
F
GI
T
EPA
V
YGV
N
LPRK
Y
PF
V
I
ACI
S
GA
L
G
AT
I
IG
Y
A
Q
-----
T
KV
Y
S
-
FG
L
PG
I
F
T
F
M
Q
T
I
P
S
T
G
---
I
D
F
T
VWA
S
VI
G
G
V
I
A
I
G
CA
F
V
G
T
VM
F
fig|364106.8.peg.4182
Escherichia coli UTI89 (2-449/624)
T
ELA
R
TI
V
A
G
VGG
A
DNI
V
S
LM
HC
A
TRLR
F
K
L
KD
E
S
K
A
Q
A
E
V
L
K
K
T
P
G
I
IM
VV
E
S
G
G
Q
F
QVV
I
G
-
-
--
N
H
VA
D
V
F
L
A
V
N
S
V
A
G
L
G
E
K
A
QQA
P
E
N
D
D
K
D
-----
N
L
L
N
RF
F
Y
V
I
SG
IFT
----
PLI
GL
M
A
A
T
G
I
L
K
G
M
LAL
A
L
-TF
Q
W
A
T
E
Q
SGT
Y
L
----
IL
F
S
A
SD
A
LF
W
F
F
PI
I
L
GY
T
A
G
KR
F
S
GN
PF
T
A
M
V
I
G
G
A
LV
---
HP
L
I
L
T
AF
EN
G
Q
KV
DALGL
DF
L
GIP
V
T
LLN
Y
S
S
S
VIP
II
F
S
AW
L
CS
I
L
E
RR
L
NT
W
L
P
S
A
I
K
NF
F
TPLL
C
L
M
V
I
T
P
I
T
F
L
L
V
GPL
S
T
W
I
S
E
L
I
A
A
------
GYL
-
WL
YQAVPA
--
FAG
AVMGG
F
W
Q
I
F
VMFG
L
H
W
G
L
IP
L
II
NNFT
V
L
G
Y
D
--------
T
M
I
P
L
L
M
P
A
I
MA
QVGAAL
G
V
F
L
CE
R
-
D
AQ
KK
VV
A
G
S
AA
L
T
G
-
L
F
GI
T
EPA
V
YGV
N
LPRK
Y
PF
V
I
ACI
S
GA
L
G
AT
I
IG
Y
A
Q
-----
T
KV
Y
S
-
FG
L
PG
I
F
T
F
M
Q
T
I
P
S
T
G
---
I
D
F
T
VWA
S
VI
G
G
V
I
A
I
G
CA
F
V
G
T
VM
F
fig|525281.3.peg.3220
Escherichia coli 83972 (2-449/624)
T
ELA
R
TI
V
A
G
VGG
A
DNI
V
S
LM
HC
A
TRLR
F
K
L
KD
E
S
K
A
Q
A
E
V
L
K
K
T
P
G
I
IM
VV
E
S
G
G
Q
F
QVV
I
G
-
-
--
N
H
VA
D
V
F
L
A
V
N
S
V
A
G
L
G
E
K
A
QQA
P
E
N
D
D
K
G
-----
N
L
L
N
RF
V
Y
V
I
SG
IFT
----
PLI
GL
M
A
A
T
G
I
L
K
G
M
LAL
A
L
-TF
Q
W
T
T
E
Q
SGT
Y
L
----
IL
F
S
A
SD
A
LF
W
F
F
PI
I
L
GY
T
A
G
KR
F
S
GN
PF
T
A
M
V
I
G
G
A
LV
---
HP
L
I
L
T
AF
EN
G
Q
KV
DALGL
DF
L
GIP
V
T
LLN
Y
S
S
S
VIP
II
F
S
AW
L
CS
I
L
E
RR
L
NA
W
L
P
S
A
I
K
NF
F
TPLL
C
L
M
V
I
T
P
I
T
F
L
L
V
GPL
S
T
W
I
S
E
L
I
A
A
------
GYL
-
WL
YQAVPA
--
FAG
AVMGG
F
W
Q
I
F
VMFG
L
H
W
G
L
IP
L
II
NNFT
V
L
G
Y
D
--------
T
M
I
P
L
L
M
P
A
I
MA
QVGAAL
G
V
F
L
CE
R
-
D
AQ
KK
VV
A
G
S
AA
L
T
G
-
L
F
GI
T
EPA
V
YGV
N
LPRK
Y
PF
V
I
ACI
S
GA
L
G
AT
I
IG
Y
A
Q
-----
T
KV
Y
S
-
FG
L
PG
I
F
T
F
M
Q
T
I
P
S
T
G
---
I
D
F
T
VWA
S
VI
G
G
V
I
A
I
G
CA
F
V
G
T
VM
L
fig|199310.4.peg.4361
Escherichia coli CFT073 (2-449/624)
T
ELA
R
TI
V
A
G
VGG
A
DNI
V
S
LM
HC
A
TRLR
F
K
L
KD
E
S
K
A
Q
A
E
V
L
K
K
T
P
G
I
IM
VV
E
S
G
G
Q
F
QVV
I
G
-
-
--
N
H
VA
D
V
F
L
A
V
N
S
V
A
G
L
G
E
K
A
QQA
P
E
N
D
D
K
G
-----
N
L
L
N
RF
V
Y
V
I
SG
IFT
----
PLI
GL
M
A
A
T
G
I
L
K
G
M
LAL
A
L
-TF
Q
W
T
T
E
Q
SGT
Y
L
----
IL
F
S
A
SD
A
LF
W
F
F
PI
I
L
GY
T
A
G
KR
F
S
GN
PF
T
A
M
V
I
G
G
A
LV
---
HP
L
I
L
T
AF
EN
G
Q
KV
DALGL
DF
L
GIP
V
T
LLN
Y
S
S
S
VIP
II
F
S
AW
L
CS
I
L
E
RR
L
NA
W
L
P
S
A
I
K
NF
F
TPLL
C
L
M
V
I
T
P
I
T
F
L
L
V
GPL
S
T
W
I
S
E
L
I
A
A
------
GYL
-
WL
YQAVPA
--
FAG
AVMGG
F
W
Q
I
F
VMFG
L
H
W
G
L
IP
L
II
NNFT
V
L
G
Y
D
--------
T
M
I
P
L
L
M
P
A
I
MA
QVGAAL
G
V
F
L
CE
R
-
D
AQ
KK
VV
A
G
S
AA
L
T
G
-
L
F
GI
T
EPA
V
YGV
N
LPRK
Y
PF
V
I
ACI
S
GA
L
G
AT
I
IG
Y
A
Q
-----
T
KV
Y
S
-
FG
L
PG
I
F
T
F
M
Q
T
I
P
S
T
G
---
I
D
F
T
VWA
S
VI
G
G
V
I
A
I
G
CA
F
V
G
T
VM
L
fig|749546.3.peg.1502
Escherichia coli MS 185-1 (2-449/624)
T
ELA
R
TI
V
A
G
VGG
A
DNI
V
S
LM
HC
A
TRLR
F
K
L
KD
E
S
K
A
Q
A
E
V
L
K
K
T
P
G
I
IM
VV
E
S
G
G
Q
F
QVV
I
G
-
-
--
N
H
VA
D
V
F
L
A
V
N
S
V
A
G
L
G
E
K
A
QQA
P
E
N
D
D
K
G
-----
N
L
L
N
RF
V
Y
V
I
SG
IFT
----
PLI
GL
M
A
A
T
G
I
L
K
G
M
LAL
A
L
-TF
Q
W
T
T
E
Q
SGT
Y
L
----
IL
F
S
A
SD
A
LF
W
F
F
PI
I
L
GY
T
A
G
KR
F
S
GN
PF
T
A
M
V
I
G
G
A
LV
---
HP
L
I
L
T
AF
EN
G
Q
KV
DALGL
DF
L
GIP
V
T
LLN
Y
S
S
S
VIP
II
F
S
AW
L
CS
I
L
E
RR
L
NA
W
L
P
S
A
I
K
NF
F
TPLL
C
L
M
V
I
T
P
I
T
F
L
L
V
GPL
S
T
W
I
S
E
L
I
A
A
------
GYL
-
WL
YQAVPA
--
FAG
AVMGG
F
W
Q
I
F
VMFG
L
H
W
G
L
IP
L
II
NNFT
V
L
G
Y
D
--------
T
M
I
P
L
L
M
P
A
I
MA
QVGAAL
G
V
F
L
CE
R
-
D
AQ
KK
VV
A
G
S
AA
L
T
G
-
L
F
GI
T
EPA
V
YGV
N
LPRK
Y
PF
V
I
ACI
S
GA
L
G
AT
I
IG
Y
A
Q
-----
T
KV
Y
S
-
FG
L
PG
I
F
T
F
M
Q
T
I
P
S
T
G
---
I
D
F
T
VWA
S
VI
G
G
V
I
A
I
G
CA
F
V
G
T
VM
L
fig|749528.3.peg.2843
Escherichia coli MS 45-1 (2-449/624)
T
ELA
R
TI
V
A
G
VGG
A
DNI
V
S
LM
HC
A
TRLR
F
K
L
KD
E
S
K
A
Q
A
E
V
L
K
K
T
P
G
I
IM
VV
E
S
G
G
Q
F
QVV
I
G
-
-
--
N
H
VA
D
V
F
L
A
V
N
S
V
A
G
L
G
E
K
A
QQA
P
E
N
D
D
K
G
-----
N
L
L
N
RF
V
Y
V
I
SG
IFT
----
PLI
GL
M
A
A
T
G
I
L
K
G
M
LAL
A
L
-TF
Q
W
T
T
E
Q
SGT
Y
L
----
IL
F
S
A
SD
A
LF
W
F
F
PI
I
L
GY
T
A
G
KR
F
S
GN
PF
T
A
M
V
I
G
G
A
LV
---
HP
L
I
L
T
AF
EN
G
Q
KV
DALGL
DF
L
GIP
V
T
LLN
Y
S
S
S
VIP
II
F
S
AW
L
CS
I
L
E
RR
L
NA
W
L
P
S
A
I
K
NF
F
TPLL
C
L
M
V
I
T
P
I
T
F
L
L
V
GPL
S
T
W
I
S
E
L
I
A
A
------
GYL
-
WL
YQAVPA
--
FAG
AVMGG
F
W
Q
I
F
VMFG
L
H
W
G
L
IP
L
II
NNFT
V
L
G
Y
D
--------
T
M
I
P
L
L
M
P
A
I
MA
QVGAAL
G
V
F
L
CE
R
-
D
AQ
KK
VV
A
G
S
AA
L
T
G
-
L
F
GI
T
EPA
V
YGV
N
LPRK
Y
PF
V
I
ACI
S
GA
L
G
AT
I
IG
Y
A
Q
-----
T
KV
Y
S
-
FG
L
PG
I
F
T
F
M
Q
T
I
P
S
T
G
---
I
D
F
T
VWA
S
VI
G
G
V
I
A
I
G
CA
F
V
G
T
VM
L
fig|656417.3.peg.4608
Escherichia coli M605 (2-449/624)
T
ELA
R
TI
V
A
G
VGG
A
DNI
V
S
LM
HC
A
TRLR
F
K
L
KD
E
S
K
A
Q
A
E
V
L
K
K
T
P
G
I
IM
VV
E
S
G
G
Q
F
QVV
I
G
-
-
--
N
H
VA
D
V
F
L
A
V
N
S
V
A
G
L
G
E
K
A
QQA
P
E
N
D
D
K
G
-----
N
L
L
N
RF
V
Y
V
I
SG
IFT
----
PLI
GL
M
A
A
T
G
I
L
K
G
M
LAL
A
L
-TF
Q
W
T
T
E
Q
SGT
Y
L
----
IL
F
S
A
SD
A
LF
W
F
F
PI
I
L
GY
T
A
G
KR
F
S
GN
PF
T
A
M
V
I
G
G
A
LV
---
HP
L
I
L
T
AF
EN
G
Q
KV
DALGL
DF
L
GIP
V
T
LLN
Y
S
S
S
VIP
II
F
S
AW
L
CS
I
L
E
RR
L
NA
W
L
P
S
A
I
K
NF
F
TPLL
C
L
M
V
I
T
P
I
T
F
L
L
V
GPL
S
T
W
I
S
E
L
I
A
A
------
GYL
-
WL
YQAVPA
--
FAG
AVMGG
F
W
Q
I
F
VMFG
L
H
W
G
L
IP
L
II
NNFT
V
L
G
Y
D
--------
T
M
I
P
L
L
M
P
A
I
MA
QVGAAL
G
V
F
L
CE
R
-
D
AQ
KK
VV
A
G
S
AA
L
T
G
-
L
F
GI
T
EPA
V
YGV
N
LPRK
Y
PF
V
I
ACI
S
GA
L
G
AT
I
IG
Y
A
Q
-----
T
KV
Y
S
-
FG
L
PG
I
F
T
F
M
Q
T
I
P
S
T
G
---
I
D
F
T
VWA
S
VI
G
G
V
I
A
I
G
CA
F
V
G
T
VM
L
fig|431946.3.peg.3716
Escherichia coli SE15 (2-449/624)
T
ELA
R
TI
V
A
G
VGG
A
DNI
V
S
LM
HC
A
TRLR
F
K
L
KD
E
S
K
A
Q
A
E
V
L
K
K
T
P
G
I
IM
VV
E
S
G
G
Q
F
QVV
I
G
-
-
--
N
H
VA
D
V
F
L
A
V
N
S
V
A
G
L
G
E
K
A
QQA
P
E
N
D
D
K
G
-----
N
L
L
N
RF
V
Y
V
I
SG
IFT
----
PLI
GL
M
A
A
T
G
I
L
K
G
M
LAL
A
L
-TF
Q
W
T
T
E
Q
SGT
Y
L
----
IL
F
S
A
SD
A
LF
W
F
F
PI
I
L
GY
T
A
G
KR
F
S
GN
PF
T
A
M
V
I
G
G
A
LV
---
HP
L
I
L
T
AF
EN
G
Q
KV
DALGL
DF
L
GIP
V
T
LLN
Y
S
S
S
VIP
II
F
S
AW
L
CS
I
L
E
RR
L
NA
W
L
P
S
A
I
K
NF
F
TPLL
C
L
M
V
I
T
P
I
T
F
L
L
V
GPL
S
T
W
I
S
E
L
I
A
A
------
GYL
-
WL
YQAVPA
--
FAG
AVMGG
F
W
Q
I
F
VMFG
L
H
W
G
L
IP
L
II
NNFT
V
L
G
Y
D
--------
T
M
I
P
L
L
M
P
A
I
MA
QVGAAL
G
V
F
L
CE
R
-
D
AQ
KK
VV
A
G
S
AA
L
T
G
-
L
F
GI
T
EPA
V
YGV
N
LPRK
Y
PF
V
I
ACI
S
GA
L
G
AT
I
IG
Y
A
Q
-----
T
KV
Y
S
-
FG
L
PG
I
F
T
F
M
Q
T
I
P
S
T
G
---
I
D
F
T
VWA
S
VI
G
G
V
I
A
I
G
CA
F
V
G
T
VM
L
fig|216592.1.peg.3490
Escherichia coli 042 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
N
NI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
H
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
Q
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FI
I
TLL
L
G
FEDIPVE
fig|216592.3.peg.3039
Escherichia coli 042 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
N
NI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
H
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
Q
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FI
I
TLL
L
G
FEDIPVE
fig|331111.12.peg.3273
Escherichia coli E24377A (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PVQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALI
S
TMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|331111.3.peg.715
Escherichia coli E24377A (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PVQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALI
S
TMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|562.375.peg.1039
Escherichia coli EC4100B (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PVQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALI
S
TMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|749545.3.peg.2280
Escherichia coli MS 182-1 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PVQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALI
S
TMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|749532.3.peg.1181
Escherichia coli MS 78-1 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PVQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALI
S
TMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|340186.3.peg.2874
Escherichia coli E110019 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALI
S
TMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
K
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|340186.5.peg.2988
Escherichia coli E110019 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALI
S
TMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
K
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|344601.3.peg.2165
Escherichia coli B171 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALI
S
TMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|344601.5.peg.2260
Escherichia coli B171 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALI
S
TMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|340185.3.peg.3387
Escherichia coli E22 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALI
S
TMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|340185.4.peg.3563
Escherichia coli E22 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALI
S
TMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|550672.3.peg.2916
Escherichia coli B088 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALI
S
TMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|595495.4.peg.4891
Escherichia coli KO11 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
Y
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALI
S
TMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|566546.3.peg.4237
Escherichia coli W (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
Y
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALI
S
TMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|566546.4.peg.2879
Escherichia coli W (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
Y
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALI
S
TMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|550677.3.peg.3248
Escherichia coli B354 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|656379.3.peg.4072
Escherichia coli FVEC1302 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|656380.3.peg.3987
Escherichia coli FVEC1412 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|749549.3.peg.3787
Escherichia coli MS 198-1 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|585056.7.peg.3214
Escherichia coli UMN026 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|749537.3.peg.2836
Escherichia coli MS 115-1 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
T
F
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|1040638.4.peg.2578
Escherichia coli O104:H4 str. LB226692 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|6666666.5357.peg.4362
Escherichia coli TY-2482 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|585055.6.peg.3011
Escherichia coli 55989 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|585055.8.peg.3015
Escherichia coli 55989 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|585034.4.peg.2754
Escherichia coli IAI1 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|585034.5.peg.2753
Escherichia coli IAI1 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|679207.4.peg.889
Escherichia coli MS 107-1 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|409438.11.peg.3131
Escherichia coli SE11 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|656419.3.peg.3531
Escherichia coli M718 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|679205.4.peg.3878
Escherichia coli MS 124-1 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|749533.3.peg.4209
Escherichia coli MS 84-1 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|439855.10.peg.2992
Escherichia coli SMS-3-5 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
E
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|340184.3.peg.1904
Escherichia coli B7A (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
M
LS
FILTLL
L
G
FEDIPVE
fig|340184.6.peg.1994
Escherichia coli B7A (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
M
LS
FILTLL
L
G
FEDIPVE
fig|679206.4.peg.279
Escherichia coli MS 119-7 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
M
LS
FILTLL
L
G
FEDIPVE
fig|679204.3.peg.2311
Escherichia coli MS 145-7 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
M
LS
FILTLL
L
G
FEDIPVE
fig|585396.4.peg.3543
Escherichia coli O111:H- str. 11128 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
M
LS
FILTLL
L
G
FEDIPVE
fig|573235.3.peg.3854
Escherichia coli O26:H11 str. 11368 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
M
LS
FILTLL
L
G
FEDIPVE
fig|656443.3.peg.3468
Escherichia coli TA271 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
M
LS
FILTLL
L
G
FEDIPVE
fig|316401.4.peg.3287
Escherichia coli ETEC H10407 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
S
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|405955.13.peg.3022
Escherichia coli APEC O1 (1-462/485)
MAKNYAA
LA
S
SVI
T
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
L
Q
PAP
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
V
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
I
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
LGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|405955.9.peg.2495
Escherichia coli APEC O1 (1-462/485)
MAKNYAA
LA
S
SVI
T
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
L
Q
PAP
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
V
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
I
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
LGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|714962.3.peg.3125
Escherichia coli IHE3034 (1-462/485)
MAKNYAA
LA
S
SVI
T
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
L
Q
PAP
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
V
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
I
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
LGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|585035.6.peg.2923
Escherichia coli S88 (1-462/485)
MAKNYAA
LA
S
SVI
T
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
L
Q
PAP
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
V
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
I
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
LGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|869729.3.peg.653
Escherichia coli UM146 (1-462/485)
MAKNYAA
LA
S
SVI
T
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
L
Q
PAP
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
V
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
I
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
LGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|364106.7.peg.3058
Escherichia coli UTI89 (1-462/485)
MAKNYAA
LA
S
SVI
T
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
L
Q
PAP
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
V
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
I
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
LGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|364106.8.peg.3059
Escherichia coli UTI89 (1-462/485)
MAKNYAA
LA
S
SVI
T
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
L
Q
PAP
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
V
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
I
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
LGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|749544.3.peg.832
Escherichia coli MS 175-1 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIM
V
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|749527.3.peg.5326
Escherichia coli MS 21-1 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|656393.3.peg.3697
Escherichia coli H299 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|749531.3.peg.4971
Escherichia coli MS 69-1 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|753642.3.peg.443
Escherichia coli NC101 (1-462/485)
MAKNYAA
LA
S
SVI
T
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
L
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
L
L
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|358709.5.peg.3713
Escherichia coli 101-1 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|413997.3.peg.2689
Escherichia coli B str. REL606 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|511693.5.peg.2706
Escherichia coli BL21 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|469008.4.peg.1033
Escherichia coli BL21(DE3) (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|749547.3.peg.2750
Escherichia coli MS 187-1 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|637912.3.peg.2724
Escherichia coli OP50 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|362663.8.peg.2711
Escherichia coli 536 (1-462/485)
MAKNYAA
LA
S
SVI
T
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
L
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
C
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
I
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|362663.9.peg.2716
Escherichia coli 536 (1-462/485)
MAKNYAA
LA
S
SVI
T
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
L
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
C
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
I
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|340197.3.peg.1470
Escherichia coli F11 (1-462/485)
MAKNYAA
LA
S
SVI
T
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
L
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
C
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
I
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|340197.5.peg.1555
Escherichia coli F11 (1-462/485)
MAKNYAA
LA
S
SVI
T
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
L
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
C
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
I
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|749550.3.peg.508
Escherichia coli MS 200-1 (1-462/485)
MAKNYAA
LA
S
SVI
T
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
L
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
C
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
I
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|656444.3.peg.3824
Escherichia coli TA280 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
S
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|670888.3.peg.3604
Escherichia coli 1827-70 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|344610.3.peg.3737
Escherichia coli 53638 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|344610.7.peg.3567
Escherichia coli 53638 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|481805.3.peg.1066
Escherichia coli ATCC 8739 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|481805.6.peg.1063
Escherichia coli ATCC 8739 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|595496.3.peg.2688
Escherichia coli BW2952 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|536056.3.peg.1020
Escherichia coli DH1 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|656414.3.peg.3148
Escherichia coli H736 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|331112.3.peg.2668
Escherichia coli HS (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|331112.6.peg.2783
Escherichia coli HS (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|749538.3.peg.586
Escherichia coli MS 116-1 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|749548.3.peg.3326
Escherichia coli MS 196-1 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|316407.3.peg.2618
Escherichia coli W3110 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|316385.5.peg.2836
Escherichia coli str. K-12 substr. DH10B (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|316385.7.peg.2902
Escherichia coli str. K-12 substr. DH10B (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|511145.12.peg.2807
Escherichia coli str. K-12 substr. MG1655 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|511145.6.peg.2791
Escherichia coli str. K-12 substr. MG1655 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|585057.4.peg.3005
Escherichia coli IAI39 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|585057.6.peg.3010
Escherichia coli IAI39 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|685038.3.peg.2706
Escherichia coli O83:H1 str. NRG 857C (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
Q
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
L
V
LS
FILTLL
L
G
FEDIPVE
fig|550676.3.peg.2640
Escherichia coli B185 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
H
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|562.373.peg.4212
Escherichia coli 1125A (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
TL
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
SE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|444454.5.peg.2606
Escherichia coli O157:H7 str. EC4024 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
TL
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
SE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|444449.5.peg.2069
Escherichia coli O157:H7 str. EC4042 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
TL
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
SE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|444448.5.peg.824
Escherichia coli O157:H7 str. EC4045 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
TL
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
SE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|444453.5.peg.305
Escherichia coli O157:H7 str. EC4076 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
TL
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
SE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|444452.5.peg.2947
Escherichia coli O157:H7 str. EC4113 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
TL
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
SE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|444450.8.peg.3911
Escherichia coli O157:H7 str. EC4115 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
TL
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
SE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|444451.5.peg.2391
Escherichia coli O157:H7 str. EC4196 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
TL
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
SE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|444447.5.peg.969
Escherichia coli O157:H7 str. EC4206 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
TL
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
SE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|478004.5.peg.2236
Escherichia coli O157:H7 str. EC4401 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
TL
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
SE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|478005.5.peg.2780
Escherichia coli O157:H7 str. EC4486 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
TL
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
SE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|478007.5.peg.2901
Escherichia coli O157:H7 str. EC508 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
TL
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
SE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|544404.4.peg.3715
Escherichia coli O157:H7 str. TW14359 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
TL
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
SE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|562.371.peg.5919
Escherichia coli 1044A (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
TL
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|562.372.peg.2142
Escherichia coli 1212A (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
TL
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|562.374.peg.3980
Escherichia coli 536A (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
TL
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|83334.1.peg.3564
Escherichia coli O157:H7 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
TL
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|155864.1.peg.3572
Escherichia coli O157:H7 EDL933 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
TL
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|155864.8.peg.3487
Escherichia coli O157:H7 EDL933 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
TL
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|478006.5.peg.3321
Escherichia coli O157:H7 str. EC4501 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
TL
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|478008.5.peg.3170
Escherichia coli O157:H7 str. EC869 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
TL
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|637388.3.peg.3109
Escherichia coli O157:H7 str. FRIK2000 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
TL
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|570506.3.peg.2612
Escherichia coli O157:H7 str. FRIK966 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
TL
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|386585.9.peg.3732
Escherichia coli O157:H7 str. Sakai (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
TL
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|502346.5.peg.3697
Escherichia coli O157:H7 str. TW14588 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
TL
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|701177.3.peg.3376
Escherichia coli O55:H7 str. CB9615 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAL
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
D
R
I
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
TL
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|749540.3.peg.1875
Escherichia coli MS 146-1 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
F
M
P
LM
V
AA
S
AA
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
LT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
fig|83333.1.peg.2670
Escherichia coli K12 (1-462/485)
MAKNYAA
LA
R
SVIA
A
L
GG
V
DNI
SA
VT
HCMTRLR
F
V
I
KDD
A
L
I
D
S
P
T
L
KTI
P
GV
L
GVVRS
D
N
Q
C
QV
II
G
-
-
--
N
T
V
S
Q
AF
Q
EV
V
S
L
L
P
-
GD
M
Q
PAQ
P
V
G
K
P
KL
-----
T
-
L
R
R
I
G
A
G
I
LD
ALIGTMS
PLIPAII
-
G
G
SM
V
K
LLA
M
IL
EMS
GV
L
T
K
G
S
P
TL
T
----
IL
N
V
I
G
DG
A
F
F
FLP
LM
V
A
H
LPR
IK
F
KT
N
MS
L
AI
A
IAG
V
LV
---
HP
S
F
IE
LM
--
A
K
AA
QGEHV
E
F
AL
IP
V
T
AVK
Y
T
Y
TVIP
A
L
V
MT
W
C
L
S
Y
IE
RW
V
DSI
T
P
A
V
TK
NFL
K
P
M
L
IV
LI
A
APLA
I
L
L
IGP
I
G
I
W
I
G
SA
ISA
LVYTIH
GYL
G
WL
--------
-SV
A
I
MG
A
LW
P
L
L
VM
T
G
M
H
R
V
F
T
P
T
II
QTIA
E
T
G
K
E
G
-------
M
V
M
P
SE
I
G
AN
LS
LG
G
SS
LAV
A
WKTK
-
N
PE
LR
QT
AL
A
AA
A
S
AIMA
GI
S
EPA
L
YGV
A
IRL
K
R
P
L
IA
SL
I
S
G
F
I
C
GA
V
A
G
M
A
G
-----
L
AS
HS
-
MA
APGL
F
T
S
V
Q
F
F
D
P
A
N
---
P
M
S
I
VW
V
-
FA
V
M
A
L
A
V
V
LS
FILTLL
L
G
FEDIPVE
Consen1
Primary consensus
MakeisseLa
tilt
vGG
dNIas
hCmTRLRlvvkDd
L
D
p
iKti
GVkGVvrss
Q
QVvfG
-
g
--
n
va
Af
ev
g
ap
-
gd
a
p
nk
kL
-----
s
lqrf
a
i
ift
----
PLIPaiia
Glllgllalil
gv
td
sgTl
----
il
v
sdglF
FLpilvgynAA
Fggn
lga
Iagllv
---
hPa
tt
--
g
aa
dFfgiPit
y
gtvIpvLiaaW
cs
iE
vrrf
Pd
ldnfLtplltllItaplA
LiIgPlG
WlgegiSa
------
gyl
-
WL
--------
AvmggLw
i
VmfGvH
gFip
ii
e
G
n
--------
l
Pil
mAn
qvGaaLAv
wktk
-
h
lr
al
Aa
sg
-
llGi
EPaiYGV
lprkkPfiaacigGa
gGa
iG
a
-----
m
hS
-
fgapGL
-
talp
m
saq
---
P
s
Vwa
-
gm
vA
v
FilTlLfGcrnvnld
Consen2
Secondary consensus
maknyaa
l
svia
l
g
sa
n
a
fg
h
s
e
l
kl
l
iltd
ii
p
-
kah
as
m
al
s
lgvqe
q
a
gd
q
kakqt
vrqi
y
f
aligtms
gfa
-
sm
kiatmaa
hw
a
qp
y
dalnfm
s
gkaa
vlmlaa
ktt
nai
ga
fllgyn
ie
yaa
h
-
e
all
v
-
p
yni
ga
mt
la
l
ldsi
a
tkml
ksmiivm
tti
l
m
i
ifsam
-
lvytih
---
g
fmhlnsnp
ilaa
f
l
vt
v
tl
yl
s
g
v
se
g
g
lg
ss
l
lraqp
kk
vr
i
paima
v
ll
irlmr
lvtslls
f
c
l
a
i
wwglp
n
amaps
fvs
q
f
ptngil
m
yv
vi
g
vf
t
l
fedipve
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character