┌─── Escherichia coli M718   
                                                                 ┌┴─── Escherichia coli B354   
                                                                ┌┴─ Escherichia coli K12 (128)  
┬───────────────────────────────────────────────────────────────┴─── Escherichia coli H591 (2)  
└────────────────────────────────────────────────────────────┬─ Escherichia coli (1-75/82) HS (1)  
                                                             └──┬─── Escherichia coli (1-75/82) EC4100B   
                                                                └┬─ Escherichia coli (1-75/82) K12 (127)  
                                                                 └┬─── Escherichia coli (1-75/82) MS 200-1   
                                                                  └─── Escherichia coli (1-75/82) MS 21-1   
  

  
[NiFe] hydrogenase metallocenter assembly protein HybG
 (5)
  
[NiFe] hydrogenase metallocenter assembly protein HypC
 (4)