fig|1040638.4.peg.2528
Escherichia coli O104:H4 str. LB226692
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|585055.6.peg.3186
Escherichia coli 55989
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|585055.8.peg.3189
Escherichia coli 55989
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|481805.3.peg.897
Escherichia coli ATCC 8739
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|481805.6.peg.894
Escherichia coli ATCC 8739
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|344601.3.peg.662
Escherichia coli B171
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|344601.5.peg.677
Escherichia coli B171
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|595496.3.peg.2842
Escherichia coli BW2952
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|536056.3.peg.867
Escherichia coli DH1
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|340185.3.peg.1844
Escherichia coli E22
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|331111.12.peg.3464
Escherichia coli E24377A
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|331111.3.peg.895
Escherichia coli E24377A
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|656408.3.peg.3163
Escherichia coli H591
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|656414.3.peg.3307
Escherichia coli H736
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|595495.4.peg.1357
Escherichia coli KO11
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|749538.3.peg.1109
Escherichia coli MS 116-1
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|679205.4.peg.1542
Escherichia coli MS 124-1
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|749540.3.peg.453
Escherichia coli MS 146-1
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|749544.3.peg.234
Escherichia coli MS 175-1
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|749548.3.peg.3571
Escherichia coli MS 196-1
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|749532.3.peg.2044
Escherichia coli MS 78-1
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|749533.3.peg.4522
Escherichia coli MS 84-1
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|585396.4.peg.3724
Escherichia coli O111:H- str. 11128
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|573235.3.peg.4040
Escherichia coli O26:H11 str. 11368
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|409438.11.peg.3298
Escherichia coli SE11
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|566546.3.peg.774
Escherichia coli W
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|566546.4.peg.3080
Escherichia coli W
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|316385.5.peg.2988
Escherichia coli str. K-12 substr. DH10B
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|316385.7.peg.3057
Escherichia coli str. K-12 substr. DH10B
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|511145.12.peg.2959
Escherichia coli str. K-12 substr. MG1655
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|511145.6.peg.2944
Escherichia coli str. K-12 substr. MG1655
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|679206.4.peg.452
Escherichia coli MS 119-7
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
SF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|585395.4.peg.3593
Escherichia coli O103:H2 str. 12009
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGV
S
CFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|550672.3.peg.3080
Escherichia coli B088
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
TP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|550676.3.peg.2804
Escherichia coli B185
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
K
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|585034.4.peg.2925
Escherichia coli IAI1
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
G
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|585034.5.peg.2923
Escherichia coli IAI1
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
G
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|749537.3.peg.4579
Escherichia coli MS 115-1
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
S
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
IS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|344610.3.peg.999
Escherichia coli 53638
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
S
Q
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|344610.7.peg.3405
Escherichia coli 53638
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
S
Q
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|550677.3.peg.3406
Escherichia coli B354
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
N
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|656444.3.peg.3998
Escherichia coli TA280
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
N
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|340184.3.peg.1068
Escherichia coli B7A
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
I
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|340184.6.peg.1125
Escherichia coli B7A
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
I
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|562.375.peg.1231
Escherichia coli EC4100B
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
I
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|331112.3.peg.2820
Escherichia coli HS
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
N
I
G
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|331112.6.peg.2951
Escherichia coli HS
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
N
I
G
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|679207.4.peg.698
Escherichia coli MS 107-1
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
I
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|679204.3.peg.1086
Escherichia coli MS 145-7
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
I
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|656443.3.peg.3640
Escherichia coli TA271
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
I
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|316401.4.peg.3461
Escherichia coli ETEC H10407
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
P
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|340186.3.peg.3740
Escherichia coli E110019
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
G
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|340186.5.peg.3927
Escherichia coli E110019
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
G
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|358709.5.peg.1453
Escherichia coli 101-1
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
GEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|413997.3.peg.2830
Escherichia coli B str. REL606
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
GEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|469008.4.peg.890
Escherichia coli BL21(DE3)
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
GEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|749545.3.peg.3007
Escherichia coli MS 182-1
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
GEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|656419.3.peg.3710
Escherichia coli M718
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFP
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
I
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
I
D
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|701177.3.peg.3532
Escherichia coli O55:H7 str. CB9615
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
Y
V
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
V
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|670897.3.peg.598
Escherichia coli 2362-75
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|362663.8.peg.2889
Escherichia coli 536
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|362663.9.peg.2898
Escherichia coli 536
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|405955.13.peg.3187
Escherichia coli APEC O1
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|405955.9.peg.2643
Escherichia coli APEC O1
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|216593.1.peg.234
Escherichia coli E2348/69
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|340197.3.peg.3330
Escherichia coli F11
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|340197.5.peg.3488
Escherichia coli F11
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|714962.3.peg.3286
Escherichia coli IHE3034
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|749550.3.peg.4353
Escherichia coli MS 200-1
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|574521.7.peg.3168
Escherichia coli O127:H6 str. E2348/69
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|585035.6.peg.3084
Escherichia coli S88
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|364106.7.peg.3222
Escherichia coli UTI89
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|364106.8.peg.3223
Escherichia coli UTI89
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|562.376.peg.3670
Escherichia coli WV_060327
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|753642.3.peg.258
Escherichia coli NC101
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
I
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|685038.3.peg.2870
Escherichia coli O83:H1 str. NRG 857C
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
I
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|562.373.peg.4400
Escherichia coli 1125A
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
E
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
Y
V
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
ASR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|444454.5.peg.2782
Escherichia coli O157:H7 str. EC4024
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
E
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
Y
V
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
ASR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|444449.5.peg.2238
Escherichia coli O157:H7 str. EC4042
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
E
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
Y
V
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
ASR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|444448.5.peg.993
Escherichia coli O157:H7 str. EC4045
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
E
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
Y
V
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
ASR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|444453.5.peg.475
Escherichia coli O157:H7 str. EC4076
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
E
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
Y
V
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
ASR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|444452.5.peg.782
Escherichia coli O157:H7 str. EC4113
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
E
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
Y
V
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
ASR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|444450.8.peg.4078
Escherichia coli O157:H7 str. EC4115
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
E
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
Y
V
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
ASR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|444451.5.peg.3294
Escherichia coli O157:H7 str. EC4196
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
E
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
Y
V
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
ASR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|444447.5.peg.1146
Escherichia coli O157:H7 str. EC4206
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
E
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
Y
V
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
ASR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|478004.5.peg.679
Escherichia coli O157:H7 str. EC4401
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
E
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
Y
V
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
ASR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|478005.5.peg.1022
Escherichia coli O157:H7 str. EC4486
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
E
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
Y
V
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
ASR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|478007.5.peg.2700
Escherichia coli O157:H7 str. EC508
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
E
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
Y
V
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
ASR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|478008.5.peg.1050
Escherichia coli O157:H7 str. EC869
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
E
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
Y
V
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
ASR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|570506.3.peg.2438
Escherichia coli O157:H7 str. FRIK966
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
E
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
Y
V
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
ASR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|544404.4.peg.3886
Escherichia coli O157:H7 str. TW14359
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
E
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
Y
V
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
ASR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|656440.3.peg.2907
Escherichia coli TA206
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
H
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
I
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|869729.3.peg.470
Escherichia coli UM146
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GD
V
VA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|585397.7.peg.3329
Escherichia coli ED1a
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
H
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|585397.9.peg.3325
Escherichia coli ED1a
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
H
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|656417.3.peg.3638
Escherichia coli M605
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
TP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
G
Q
K
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|439855.10.peg.3150
Escherichia coli SMS-3-5
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALA
D
DA
AP
I
H
NG
G
-------------------------------------
N
LLKQSSM
S
T
G
N
V
Q
QT
I
--
DA
V
D
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
N
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
D
I
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
I
D
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|749527.3.peg.1120
Escherichia coli MS 21-1
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALA
D
DA
EP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
N
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
K
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
I
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|562.371.peg.5732
Escherichia coli 1044A
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
E
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIK
T
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
Y
V
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
ASR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|562.372.peg.2328
Escherichia coli 1212A
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
E
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIK
T
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
Y
V
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
ASR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|562.374.peg.3792
Escherichia coli 536A
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
E
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIK
T
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
Y
V
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
ASR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|478006.5.peg.571
Escherichia coli O157:H7 str. EC4501
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
E
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIK
T
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
Y
V
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
ASR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|386585.9.peg.3901
Escherichia coli O157:H7 str. Sakai
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
E
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIK
T
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
Y
V
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
ASR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|502346.5.peg.3524
Escherichia coli O157:H7 str. TW14588
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
E
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIK
T
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
Y
V
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
ASR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|216592.1.peg.3665
Escherichia coli 042
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
N
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
V
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALA
D
DA
AP
I
H
NG
G
-------------------------------------
N
LLKQSSM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
LN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
IT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|216592.3.peg.3205
Escherichia coli 042
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
N
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
V
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALA
D
DA
AP
I
H
NG
G
-------------------------------------
N
LLKQSSM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
LN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
IT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|525281.3.peg.4604
Escherichia coli 83972
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
I
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
N
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
H
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
I
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|655817.3.peg.3268
Escherichia coli ABU 83972
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
I
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
N
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
H
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
I
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|749546.3.peg.3039
Escherichia coli MS 185-1
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
I
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
N
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
H
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
I
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|749528.3.peg.1993
Escherichia coli MS 45-1
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
I
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
N
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
H
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
I
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|431946.3.peg.2786
Escherichia coli SE15
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
A
V
Q
LV
SI
E
W
Q
E
L
PVITSSEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|155864.8.peg.3658
Escherichia coli O157:H7 EDL933
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
E
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIK
T
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
Y
V
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
ASR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
X
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|199310.1.peg.3362
Escherichia coli CFT073
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
I
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
N
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
N
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
H
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
I
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|199310.4.peg.3241
Escherichia coli CFT073
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
I
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
N
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
P
E
I
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITSPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
N
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
I
GGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
H
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
I
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|749531.3.peg.5152
Escherichia coli MS 69-1
MEAREATATG
ESC
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
I
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALA
D
DA
AP
I
H
NG
G
-------------------------------------
N
LLKQSSM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
N
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LSGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
S
ECQN
Q
Q
S
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|340185.4.peg.1955
Escherichia coli E22
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|83333.1.peg.2818
Escherichia coli K12
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|316407.3.peg.2762
Escherichia coli W3110
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|511693.5.peg.2849
Escherichia coli BL21
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
GEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|656437.3.peg.3217
Escherichia coli TA143
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALA
D
DA
EP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
N
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
IT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
I
D
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|656393.3.peg.3874
Escherichia coli H299
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
G
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALA
D
DA
AP
I
H
NG
G
-------------------------------------
N
LLKQSSM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
N
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|585057.4.peg.3397
Escherichia coli IAI39
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALA
D
DA
EP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
KMG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
K
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
I
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|585057.6.peg.3404
Escherichia coli IAI39
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALA
D
DA
EP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
KMG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
K
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
I
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|83334.1.peg.3725
Escherichia coli O157:H7
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
E
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIK
T
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
Y
V
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
ASR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|155864.1.peg.3744
Escherichia coli O157:H7 EDL933
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
E
E
L
PVITTPEA
ALAEDA
AP
I
H
NG
G
-------------------------------------
N
LLKQSTM
S
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
D
IP
WSC
VRVIK
T
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
Y
V
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
ASR
EG
D
-----------
A
N
P
LTGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
VD
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|656379.3.peg.4247
Escherichia coli FVEC1302
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALA
D
DA
EP
I
H
NG
G
-------------------------------------
N
LLKQSTM
T
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
N
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LSGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
I
D
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|656380.3.peg.4159
Escherichia coli FVEC1412
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALA
D
DA
EP
I
H
NG
G
-------------------------------------
N
LLKQSTM
T
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
N
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LSGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
I
D
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|749549.3.peg.558
Escherichia coli MS 198-1
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALA
D
DA
EP
I
H
NG
G
-------------------------------------
N
LLKQSTM
T
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
N
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LSGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
I
D
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|585056.7.peg.3382
Escherichia coli UMN026
MR
V
DA
IA
KVTG
R
ARY
TD
D
Y
--
V
M
A
G
M
CY
A
K
Y
VRSPIAHG
YA
V
S
IN
DEQ
AR
S
LPGVLA
IF
T
WEDV
PDI
PFA
TAG
H
A
WT
L
DEN
K
R
DTADR
A
L
L
T
RH
VRH
H
GDAVA
I
VVA
R
D
E
L
---------
T
A
EK
AA
Q
LV
SI
E
W
Q
E
L
PVITTPEA
ALA
D
DA
EP
I
H
NG
G
-------------------------------------
N
LLKQSTM
T
T
G
N
V
Q
QT
I
--
DA
AD
Y
Q
V
Q
G
H
Y
Q
TP
VI
QHC
H
ME
S
V
T
S
L
A
-
W
ME
D
D
SR
I
TI
V
SSTQIP
HIV
RR
V
V
G
Q
A
L
N
IP
WSC
VRVIKP
F
VGGGFG
N
KQDVL
E
E
P
M
A
A
F
LT
SKLG
G
I
PVKV
S
L
S
REE
C
F
L
AT
R
T
RHA
FTIDG
Q
MG
V
N
RDG
T
L
--
-
--
KGY
S
L
D
VLS
NTG
A
YA
S
H
GHS
I
AS
AG
G
N
KVAY
LYP
RCAYAYSSK
T
C
Y
T
NLP
SA
GAMRGYGAP
Q
V
V
FAVE
S
M
LD
DA
A
T
A
LGIDPVEIR
L
RN
AAR
EG
D
-----------
A
N
P
LSGKRIY
S
AG
L
P
ECL
E
K
GRK
I
F
E
W
EK
R
R
A
ECQN
Q
Q
G
NL
R
R
G
VGVACFSYTSN
T
W
P
VG
-
---
------
---
-
VE
I
AGARL
L
MN
Q
DGT
IN
V
Q
SG
A
T
E
IG
Q
G
A
DTV
F
SQ
M
V
AE
T
V
GVP
VS
DV
R
VIS
T
Q
DTD
VT
PFD
P
GA
F
AS
R
Q
S
YV
A
AP
A
L
R
S
AA
LL
L
K
EKI
IA
H
A
A
V
ML
H
QS
AMNL
T
L
I
K
G
H
IV
L
V
E
R
P
E
EPL
M
S
LK
D
L
A
MD
AF
Y
HP
E
R
G
---
G
Q
L
S
AE
S
SI
K
T
T
T
-----
NPPA
FG
CT
FV
DL
T
I
D
I
A
LCK
V
T
I
N
R
I
L
N
V
H
D
S
G
H
ILNP
L
LA
E
GQV
H
G
G
M
G
MGIG
W
AL
F
EEMI
I
DAK
S
G
VVR
N
P
N
L
LD
Y
KM
P
TMP
D
L
PQ
L
E
S
AF
V
EI
N
E
P
-Q
S
A
Y
G
H
KSLGE
P
P
I
I
P
VAAAI
R
NAV
KM
ATG
V
A
I
N
TL
P
L
TPK
R
LYEEFHLAGLI
fig|155864.8.peg.3673
Escherichia coli O157:H7 EDL933 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
D
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
X
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|562.371.peg.5717
Escherichia coli 1044A (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
D
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|562.373.peg.4415
Escherichia coli 1125A (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
D
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|562.372.peg.2343
Escherichia coli 1212A (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
D
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|562.374.peg.3777
Escherichia coli 536A (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
D
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|83334.1.peg.3740
Escherichia coli O157:H7 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
D
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|155864.1.peg.3759
Escherichia coli O157:H7 EDL933 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
D
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|444454.5.peg.2797
Escherichia coli O157:H7 str. EC4024 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
D
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|444449.5.peg.2253
Escherichia coli O157:H7 str. EC4042 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
D
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|444448.5.peg.1008
Escherichia coli O157:H7 str. EC4045 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
D
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|444453.5.peg.490
Escherichia coli O157:H7 str. EC4076 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
D
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|444452.5.peg.767
Escherichia coli O157:H7 str. EC4113 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
D
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|444450.8.peg.4093
Escherichia coli O157:H7 str. EC4115 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
D
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|444451.5.peg.3309
Escherichia coli O157:H7 str. EC4196 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
D
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|444447.5.peg.1161
Escherichia coli O157:H7 str. EC4206 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
D
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|478004.5.peg.694
Escherichia coli O157:H7 str. EC4401 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
D
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|478005.5.peg.1037
Escherichia coli O157:H7 str. EC4486 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
D
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|478006.5.peg.586
Escherichia coli O157:H7 str. EC4501 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
D
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|478007.5.peg.2715
Escherichia coli O157:H7 str. EC508 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
D
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|386585.9.peg.3916
Escherichia coli O157:H7 str. Sakai (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
D
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|544404.4.peg.3901
Escherichia coli O157:H7 str. TW14359 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
D
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|502346.5.peg.3509
Escherichia coli O157:H7 str. TW14588 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
D
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|701177.3.peg.3547
Escherichia coli O55:H7 str. CB9615 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
D
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|679205.4.peg.1557
Escherichia coli MS 124-1 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
RDG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
E
A
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|749533.3.peg.4507
Escherichia coli MS 84-1 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
RDG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
E
A
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|749537.3.peg.4593
Escherichia coli MS 115-1 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
S
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|585055.6.peg.3201
Escherichia coli 55989 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
E
A
VADV
QLA
T
P
G
V
V
R
D
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
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DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|585055.8.peg.3204
Escherichia coli 55989 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
E
A
VADV
QLA
T
P
G
V
V
R
D
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|481805.3.peg.882
Escherichia coli ATCC 8739 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
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V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
E
A
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|481805.6.peg.879
Escherichia coli ATCC 8739 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
E
A
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|1040638.4.peg.2543
Escherichia coli O104:H4 str. LB226692 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
E
A
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|340184.3.peg.1083
Escherichia coli B7A (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
E
A
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|340184.6.peg.1140
Escherichia coli B7A (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
E
A
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|595495.4.peg.1342
Escherichia coli KO11 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAG
V
PDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
E
A
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|679207.4.peg.683
Escherichia coli MS 107-1 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAG
V
PDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
E
A
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|679204.3.peg.1101
Escherichia coli MS 145-7 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
E
A
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|566546.3.peg.759
Escherichia coli W (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAG
V
PDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
E
A
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|566546.4.peg.3095
Escherichia coli W (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAG
V
PDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
E
A
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|478008.5.peg.1065
Escherichia coli O157:H7 str. EC869 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
D
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
H
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|637388.3.peg.3295
Escherichia coli O157:H7 str. FRIK2000 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
D
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
H
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|570506.3.peg.2423
Escherichia coli O157:H7 str. FRIK966 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
EV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
D
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
H
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|670888.3.peg.3403
Escherichia coli 1827-70 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|344610.3.peg.984
Escherichia coli 53638 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|344610.7.peg.3390
Escherichia coli 53638 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|550677.3.peg.3421
Escherichia coli B354 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|595496.3.peg.2857
Escherichia coli BW2952 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|536056.3.peg.852
Escherichia coli DH1 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|331111.12.peg.3479
Escherichia coli E24377A (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAG
V
PDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|331111.3.peg.910
Escherichia coli E24377A (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAG
V
PDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|316401.4.peg.3476
Escherichia coli ETEC H10407 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|656379.3.peg.4263
Escherichia coli FVEC1302 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|656380.3.peg.4175
Escherichia coli FVEC1412 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|656414.3.peg.3322
Escherichia coli H736 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|331112.3.peg.2835
Escherichia coli HS (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|331112.6.peg.2966
Escherichia coli HS (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|83333.1.peg.2833
Escherichia coli K12 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|656419.3.peg.3726
Escherichia coli M718 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|749540.3.peg.436
Escherichia coli MS 146-1 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|749548.3.peg.3556
Escherichia coli MS 196-1 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|749549.3.peg.542
Escherichia coli MS 198-1 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|749527.3.peg.1105
Escherichia coli MS 21-1 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|749532.3.peg.2059
Escherichia coli MS 78-1 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAG
V
PDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|409438.11.peg.3313
Escherichia coli SE11 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|656437.3.peg.3233
Escherichia coli TA143 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|656444.3.peg.4013
Escherichia coli TA280 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|585056.7.peg.3398
Escherichia coli UMN026 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|316407.3.peg.2777
Escherichia coli W3110 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|316385.5.peg.3003
Escherichia coli str. K-12 substr. DH10B (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|316385.7.peg.3072
Escherichia coli str. K-12 substr. DH10B (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|511145.12.peg.2974
Escherichia coli str. K-12 substr. MG1655 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|511145.6.peg.2959
Escherichia coli str. K-12 substr. MG1655 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|344601.3.peg.646
Escherichia coli B171 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
S
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
E
A
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|344601.5.peg.661
Escherichia coli B171 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
S
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
E
A
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|340185.3.peg.1859
Escherichia coli E22 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
S
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
E
A
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|340185.4.peg.1970
Escherichia coli E22 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
S
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
E
A
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|656408.3.peg.3178
Escherichia coli H591 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
S
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
E
A
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|679206.4.peg.467
Escherichia coli MS 119-7 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
S
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
E
A
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|585395.4.peg.3608
Escherichia coli O103:H2 str. 12009 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
S
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
E
A
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|656443.3.peg.3656
Escherichia coli TA271 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
S
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
E
A
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|358709.5.peg.1438
Escherichia coli 101-1 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
A
K
DA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FR
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|413997.3.peg.2845
Escherichia coli B str. REL606 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
A
K
DA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FR
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|511693.5.peg.2864
Escherichia coli BL21 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
A
K
DA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FR
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|469008.4.peg.875
Escherichia coli BL21(DE3) (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
A
K
DA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FR
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|749545.3.peg.3114
Escherichia coli MS 182-1 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
A
K
DA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FR
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|585057.4.peg.3412
Escherichia coli IAI39 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|585057.6.peg.3419
Escherichia coli IAI39 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|749531.3.peg.5137
Escherichia coli MS 69-1 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|550676.3.peg.2820
Escherichia coli B185 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
Y
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|439855.10.peg.3165
Escherichia coli SMS-3-5 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
H
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
A
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|685038.3.peg.2885
Escherichia coli O83:H1 str. NRG 857C (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
N
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|340186.3.peg.3755
Escherichia coli E110019 (173-951/958)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
AD
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
E
A
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|340186.5.peg.3942
Escherichia coli E110019 (173-951/958)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
AD
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
E
A
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|749538.3.peg.1133
Escherichia coli MS 116-1 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
G
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|749544.3.peg.217
Escherichia coli MS 175-1 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
G
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|550672.3.peg.3095
Escherichia coli B088 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
N
A
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|562.375.peg.1247
Escherichia coli EC4100B (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
N
A
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|585034.4.peg.2940
Escherichia coli IAI1 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
N
A
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|585034.5.peg.2938
Escherichia coli IAI1 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
N
A
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|525281.3.peg.4619
Escherichia coli 83972 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|655817.3.peg.3283
Escherichia coli ABU 83972 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|405955.13.peg.3202
Escherichia coli APEC O1 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|405955.9.peg.2657
Escherichia coli APEC O1 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|199310.1.peg.3377
Escherichia coli CFT073 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|199310.4.peg.3256
Escherichia coli CFT073 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|656393.3.peg.3889
Escherichia coli H299 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLE
E
DN
R
HAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|714962.3.peg.3301
Escherichia coli IHE3034 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|749546.3.peg.3353
Escherichia coli MS 185-1 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|749528.3.peg.1978
Escherichia coli MS 45-1 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|753642.3.peg.243
Escherichia coli NC101 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDN
R
HAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|585035.6.peg.3099
Escherichia coli S88 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|431946.3.peg.2801
Escherichia coli SE15 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAP
E
TLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|656440.3.peg.2922
Escherichia coli TA206 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDN
R
HAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
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DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
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Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|869729.3.peg.455
Escherichia coli UM146 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|364106.7.peg.3237
Escherichia coli UTI89 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|364106.8.peg.3238
Escherichia coli UTI89 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|670897.3.peg.583
Escherichia coli 2362-75 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VV
V
E
S
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
D
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|585396.4.peg.3739
Escherichia coli O111:H- str. 11128 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
S
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
N
A
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|573235.3.peg.4055
Escherichia coli O26:H11 str. 11368 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
S
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
D
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
N
A
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|362663.8.peg.2904
Escherichia coli 536 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
N
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
I
L
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|362663.9.peg.2913
Escherichia coli 536 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
N
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
I
L
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|340197.3.peg.3345
Escherichia coli F11 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
N
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
I
L
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|340197.5.peg.3503
Escherichia coli F11 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
N
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
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Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
I
L
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|749550.3.peg.4338
Escherichia coli MS 200-1 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
N
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
I
L
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|562.376.peg.3685
Escherichia coli WV_060327 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
EE
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LREKI
LF
H
G
A
Q
I
L
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|585397.7.peg.3344
Escherichia coli ED1a (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LRE
E
I
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|585397.9.peg.3340
Escherichia coli ED1a (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
AAE
V
L
HC
P
PQ
DV
H
VIS
-
GDTD
HA
L
FD
K
GA
Y
AS
S
G
T
CF
S
GN
A
A
R
L
AA
EN
LRE
E
I
LF
H
G
A
Q
ML
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
I
Y
GA
T
L
RA
IG
H
SM
S
EE
I
I
Y
DA
E
-
G
HPL
T
R
DL
RS
Y
GA
P
KIG
DIP
R
D
F
R
A
V
L
VP
S
D
D
KV
G
P
F
GAKS
I
S
E
I
G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|656417.3.peg.3653
Escherichia coli M605 (173-949/956)
GKHY
PK
T
DA
AK
M
V
QA
K
PC
Y
VE
D
R
--
V
T
A
D
AC
V
I
K
M
L
RSP
H
AH
A
LI
T
H
LD
VSK
A
E
A
LPGV
VH
VIT
HLNC
PDI
YYT
PG
G
Q
S
--
-
-AP
E
P
S
PL
DR
R
M
F
G
KK
M
RH
V
GD
R
VA
A
VVAE
S
E
D
---------
I
A
LE
A
L
K
L
I
DV
EYE
V
L
KPVMSIDE
A
M
AEDA
PV
VH
DE
P
VVYVAGAPDTLEDDNSHAAQRGEHMIINFPIGSRPRK
N
IAASIHG
H
I
GD
M
D
KG
F
--
AD
ADV
I
I
E
R
TY
N
ST
QA
Q
Q
C
P
T
E
T
H
I
C
F
T
R
M
--
DG
D
RL
V
I
H
A
STQ
V
P
WHL
RR
Q
VA
R
L
V
G
M
K
QHK
V
H
VIK
E
R
VGGGFG
S
KQD
I
L
L
E
E
V
C
A
W
A
T
C-VT
GRPV
LF
R
Y
T
REE
E
F
I
A
N
T
S
RH
V
AKVTV
K
L
GA
K
K
DG
R
LTA
V
--
---
K
M
D
FRA
NTG
P
Y
G
N
H
SLT
V
PC
N
G
P
A
LSLP
LYP
CDNVDFQVT
T
Y
Y
S
N
IC
PN
GA
YQ
GYGAP
K
G
N
FA
I
T
M
AL
A
ELAE
Q
L
Q
ID
QL
EI
I
E
RN
RVH
EG
Q
ELKILGAIGEGK
A
P
TSVPSAA
S
CA
L
E
E
I
LR
Q
GR
E
M
I
Q
W
SS
P
K
P
----
Q
N
G
--
-
-
-
-----------
D
W
H
I
G
R
GVA
IIMQKS
GIP
D
I
D
Q
A
NCM
I
K
LE
S
DGT
FI
V
H
SG
G
A
DIGTG
L
DTV
V
T
K
L
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V
L
HC
P
PQ
DV
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VIS
-
GDTD
HA
L
FD
K
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AS
S
G
T
CF
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GN
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A
R
L
AA
EN
LREKI
LF
H
G
A
Q
I
L
G
EP
VADV
QLA
T
P
G
V
V
R
G
K
K
G
E
---
V
S
FG
E
I
A
--
--
H
KG
E
T
G
TGF
G
S
L
V
GT
G
S
Y
I
T
P
D
-----
FAFP
Y
G
AN
F
A
EV
A
V
N
T
R
TGE
I
R
L
D
K
F
Y
A
L
L
D
C
G
T
PV
NP
E
LA
L
GQ
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Y
GA
T
L
RA
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SM
S
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DA
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-
G
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DL
RS
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DIP
R
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R
A
V
L
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D
D
KV
G
P
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GAKS
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S
E
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G
V
N
G
A
A
P
AIA
T
A
I
HD
A
C
GI
W
L
R
EW
H
F
TP
E
K
I
fig|749531.3.peg.1384
Escherichia coli MS 69-1 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
CL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
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M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
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LT
L
W
T
S
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Q
M
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R
T
D
L
A
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T
L
K
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VR
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N
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R
P
A
TLQHL
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Q
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K
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T
P
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T
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V
Q
QSE
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LY
AG
A
N
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--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
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K
A
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F
R
I
L
N
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VD
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
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T
G
A
D
K
F
G
W
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R
N
A
----
T
P
G
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R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
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L
A
Q
T
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Q
V
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L
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F-
P
VS
A
G
S
G
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G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
D
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
M
SKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
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GAM
T
MG
M
G
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AL
M
EE
L
A
V
D
D
R
L
G
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H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|585055.6.peg.290
Escherichia coli 55989 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
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L
W
T
S
N
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M
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L
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N
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H
R
T
A
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RI
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Q
S
G
K
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TA
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SH
ESW
S
G
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LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
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--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
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K
A
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R
I
L
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VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
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D
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F
G
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R
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A
----
T
P
G
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R
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G
-----------
E
W
L
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H
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AGFRNN
---
L
L
E
K
S
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H
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Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
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L
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T
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-
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SS
F-
P
VS
A
G
S
G
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W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
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T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
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H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|585055.8.peg.291
Escherichia coli 55989 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
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L
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T
S
N
Q
M
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T
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L
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L
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L
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P
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N
TT
H
R
T
A
TLQHL
RI
GA
D
Q
S
G
K
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TA
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SH
ESW
S
G
N
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G
T
P
E
T
A
V
Q
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L
LY
AG
A
N
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--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
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K
A
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R
I
L
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DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
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A
D
K
F
G
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R
N
A
----
T
P
G
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R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|550672.3.peg.295
Escherichia coli B088 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
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P
VEN
VR
I
I
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P
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G
K
LF
L
R
S
D
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L
L
A
A
L
A
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M
L
P
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PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
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G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
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--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
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I
A
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K
A
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F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
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R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|340184.3.peg.795
Escherichia coli B7A (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
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L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|340184.6.peg.829
Escherichia coli B7A (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|536056.3.peg.3514
Escherichia coli DH1 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|340185.3.peg.2741
Escherichia coli E22 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|340185.4.peg.2889
Escherichia coli E22 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|331111.12.peg.615
Escherichia coli E24377A (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
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M
LGVP
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Q
V
-
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L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|331111.3.peg.2850
Escherichia coli E24377A (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
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R
T
D
L
A
K
T
L
K
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L
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R
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N
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H
R
P
A
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RI
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D
Q
S
G
K
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TA
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SH
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S
G
N
LPG
G
T
P
E
T
A
V
Q
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L
LY
AG
A
N
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L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
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F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
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R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
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M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|562.375.peg.5201
Escherichia coli EC4100B (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
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R
T
D
L
A
K
T
L
K
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P
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VR
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I
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L
R
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L
L
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L
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L
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R
PS
I
P
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N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
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L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
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K
A
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F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|656408.3.peg.195
Escherichia coli H591 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
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R
T
D
L
A
K
T
L
K
V
P
VEN
VR
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I
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P
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L
R
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D
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L
L
A
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L
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P
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N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
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--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
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I
A
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K
A
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F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|656414.3.peg.467
Escherichia coli H736 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
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M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|585034.4.peg.274
Escherichia coli IAI1 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
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M
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LE
Q
V
-
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L
GD
SS
F-
P
VS
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G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|585034.5.peg.273
Escherichia coli IAI1 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
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R
T
D
L
A
K
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L
K
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L
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H
R
P
A
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K
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G
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V
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LY
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A
N
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--
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L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
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I
A
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K
A
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F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
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R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
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M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|83333.1.peg.280
Escherichia coli K12 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
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L
W
T
S
N
Q
M
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R
T
D
L
A
K
T
L
K
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VEN
VR
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L
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TT
H
R
P
A
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RI
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D
Q
S
G
K
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TA
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SH
ESW
S
G
N
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G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
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--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
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K
A
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F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|595495.4.peg.602
Escherichia coli KO11 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
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L
W
T
S
N
Q
M
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T
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L
A
K
T
L
K
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P
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VR
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L
R
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D
A
L
L
A
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L
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P
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N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
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G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
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L
--
--------R
L
A
T
L
D
LP
EG
N
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AP
G
EA
P
G
L
M
A
L
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I
A
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K
A
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F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
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R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|679207.4.peg.2205
Escherichia coli MS 107-1 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
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M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|749538.3.peg.58
Escherichia coli MS 116-1 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|679206.4.peg.4279
Escherichia coli MS 119-7 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|679204.3.peg.3798
Escherichia coli MS 145-7 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|749540.3.peg.226
Escherichia coli MS 146-1 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|749544.3.peg.3368
Escherichia coli MS 175-1 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|749545.3.peg.680
Escherichia coli MS 182-1 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
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M
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LE
Q
V
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L
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SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
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GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|749532.3.peg.2799
Escherichia coli MS 78-1 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
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S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
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R
T
D
L
A
K
T
L
K
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VR
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R
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L
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R
P
A
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RI
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D
Q
S
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K
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TA
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SH
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G
T
P
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T
A
V
Q
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L
LY
AG
A
N
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L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
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K
A
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F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
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M
LGVP
LE
Q
V
-
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L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|585395.4.peg.269
Escherichia coli O103:H2 str. 12009 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
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DG
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L
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T
S
N
Q
M
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T
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L
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K
T
L
K
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N
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R
P
A
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RI
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D
Q
S
G
K
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TA
I
SH
ESW
S
G
N
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G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
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K
A
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F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
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Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|573235.3.peg.313
Escherichia coli O26:H11 str. 11368 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
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H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
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L
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T
S
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M
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L
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P
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N
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H
R
P
A
TLQHL
RI
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D
Q
S
G
K
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TA
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SH
ESW
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G
N
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G
T
P
E
T
A
V
Q
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L
LY
AG
A
N
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--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
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K
A
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R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|409438.11.peg.420
Escherichia coli SE11 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
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R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
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P
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L
R
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D
A
L
L
A
A
L
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M
L
P
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PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|656443.3.peg.477
Escherichia coli TA271 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|566546.3.peg.3479
Escherichia coli W (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|566546.4.peg.356
Escherichia coli W (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|316407.3.peg.274
Escherichia coli W3110 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|316385.5.peg.260
Escherichia coli str. K-12 substr. DH10B (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|316385.7.peg.268
Escherichia coli str. K-12 substr. DH10B (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|511145.12.peg.288
Escherichia coli str. K-12 substr. MG1655 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|511145.6.peg.287
Escherichia coli str. K-12 substr. MG1655 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|344601.3.peg.1899
Escherichia coli B171 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
E
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|344601.5.peg.1980
Escherichia coli B171 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
E
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|550677.3.peg.706
Escherichia coli B354 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GV
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
C
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
N
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
P
T
I
P
N
N
TT
H
R
P
A
TLQHL
RI
G
T
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
R
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
S
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|481805.3.peg.3584
Escherichia coli ATCC 8739 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
I
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QP
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
P
T
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|481805.6.peg.3564
Escherichia coli ATCC 8739 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
I
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QP
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
P
T
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|701177.3.peg.363
Escherichia coli O55:H7 str. CB9615 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVL
P
VI
-
----
---
---
TA
S
N
A
GA
L
SKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
ML
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|656444.3.peg.727
Escherichia coli TA280 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
SY
E
W
Y
EE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
P
T
I
P
N
N
TT
H
R
P
A
TLQHL
RI
G
T
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
F
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
G
I
A
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
ML
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
H
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
V
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|216592.1.peg.4954
Escherichia coli 042 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
Y
EE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
S
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
G
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
P
T
I
P
N
N
TT
H
R
P
A
TLQHL
RI
G
T
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
ML
H
GA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|216592.3.peg.332
Escherichia coli 042 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
Y
EE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
S
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
G
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
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ARAV
K
RPVKV
M
L
P
R
P
T
I
P
N
N
TT
H
R
P
A
TLQHL
RI
G
T
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
ML
H
GA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|562.371.peg.1275
Escherichia coli 1044A (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVL
P
VI
-
----
---
---
TA
S
N
A
GA
L
SKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
I
D
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
IL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|562.373.peg.363
Escherichia coli 1125A (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVL
P
VI
-
----
---
---
TA
S
N
A
GA
L
SKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
I
D
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
IL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|562.372.peg.730
Escherichia coli 1212A (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVL
P
VI
-
----
---
---
TA
S
N
A
GA
L
SKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
I
D
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
IL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|562.374.peg.5889
Escherichia coli 536A (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVL
P
VI
-
----
---
---
TA
S
N
A
GA
L
SKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
I
D
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
IL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|83334.1.peg.396
Escherichia coli O157:H7 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVL
P
VI
-
----
---
---
TA
S
N
A
GA
L
SKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
I
D
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
IL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|155864.1.peg.309
Escherichia coli O157:H7 EDL933 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVL
P
VI
-
----
---
---
TA
S
N
A
GA
L
SKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
I
D
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
IL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|155864.8.peg.307
Escherichia coli O157:H7 EDL933 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVL
P
VI
-
----
---
---
TA
S
N
A
GA
L
SKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
I
D
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
IL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|444454.5.peg.4776
Escherichia coli O157:H7 str. EC4024 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVL
P
VI
-
----
---
---
TA
S
N
A
GA
L
SKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
I
D
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
IL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|444449.5.peg.5117
Escherichia coli O157:H7 str. EC4042 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVL
P
VI
-
----
---
---
TA
S
N
A
GA
L
SKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
I
D
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
IL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|444448.5.peg.2992
Escherichia coli O157:H7 str. EC4045 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVL
P
VI
-
----
---
---
TA
S
N
A
GA
L
SKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
I
D
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
IL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|444453.5.peg.3964
Escherichia coli O157:H7 str. EC4076 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVL
P
VI
-
----
---
---
TA
S
N
A
GA
L
SKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
I
D
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
IL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|444452.5.peg.2157
Escherichia coli O157:H7 str. EC4113 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVL
P
VI
-
----
---
---
TA
S
N
A
GA
L
SKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
I
D
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
IL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|444450.8.peg.454
Escherichia coli O157:H7 str. EC4115 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVL
P
VI
-
----
---
---
TA
S
N
A
GA
L
SKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
I
D
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
IL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|444451.5.peg.3010
Escherichia coli O157:H7 str. EC4196 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVL
P
VI
-
----
---
---
TA
S
N
A
GA
L
SKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
I
D
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
IL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|444447.5.peg.3163
Escherichia coli O157:H7 str. EC4206 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVL
P
VI
-
----
---
---
TA
S
N
A
GA
L
SKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
I
D
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
IL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|478004.5.peg.2591
Escherichia coli O157:H7 str. EC4401 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVL
P
VI
-
----
---
---
TA
S
N
A
GA
L
SKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
I
D
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
IL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|478005.5.peg.3523
Escherichia coli O157:H7 str. EC4486 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVL
P
VI
-
----
---
---
TA
S
N
A
GA
L
SKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
I
D
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
IL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|478006.5.peg.2399
Escherichia coli O157:H7 str. EC4501 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVL
P
VI
-
----
---
---
TA
S
N
A
GA
L
SKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
I
D
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
IL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|478008.5.peg.3732
Escherichia coli O157:H7 str. EC869 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVL
P
VI
-
----
---
---
TA
S
N
A
GA
L
SKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
I
D
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
IL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|637388.3.peg.677
Escherichia coli O157:H7 str. FRIK2000 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVL
P
VI
-
----
---
---
TA
S
N
A
GA
L
SKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
I
D
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
IL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|570506.3.peg.1806
Escherichia coli O157:H7 str. FRIK966 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVL
P
VI
-
----
---
---
TA
S
N
A
GA
L
SKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
I
D
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
IL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|386585.9.peg.408
Escherichia coli O157:H7 str. Sakai (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVL
P
VI
-
----
---
---
TA
S
N
A
GA
L
SKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
I
D
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
IL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|544404.4.peg.319
Escherichia coli O157:H7 str. TW14359 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVL
P
VI
-
----
---
---
TA
S
N
A
GA
L
SKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
I
D
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
IL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|502346.5.peg.954
Escherichia coli O157:H7 str. TW14588 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVL
P
VI
-
----
---
---
TA
S
N
A
GA
L
SKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
I
D
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
IL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|656379.3.peg.1143
Escherichia coli FVEC1302 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
Y
EE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
CL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
A
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
P
T
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
G
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
V
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|656380.3.peg.898
Escherichia coli FVEC1412 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
Y
EE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
CL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
A
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
P
T
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
G
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
V
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|749549.3.peg.47
Escherichia coli MS 198-1 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
Y
EE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
CL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
A
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
P
T
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
G
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
V
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|585056.7.peg.510
Escherichia coli UMN026 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
Y
EE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
CL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
A
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
P
T
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
G
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
V
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|316401.4.peg.389
Escherichia coli ETEC H10407 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
M
A
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
T
T
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
A
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
P
T
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
H
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|670888.3.peg.858
Escherichia coli 1827-70 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--GTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
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RPVKV
M
L
P
R
P
T
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
ML
H
EA
T
A
G
---
G
R
L
I
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|344610.3.peg.2477
Escherichia coli 53638 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--GTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
P
T
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
ML
H
EA
T
A
G
---
G
R
L
I
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|344610.7.peg.1347
Escherichia coli 53638 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--GTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
P
T
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
ML
H
EA
T
A
G
---
G
R
L
I
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|6666666.5357.peg.249
Escherichia coli TY-2482 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
T
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRCFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
Q
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
G
G
A
NT
S
TS
G
V
Y
A
A
C
MK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|656419.3.peg.449
Escherichia coli M718 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
F
EE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
P
T
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
V
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
V
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
I
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
ML
N
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|413997.3.peg.258
Escherichia coli B str. REL606 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
M
A
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
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LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
P
T
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
ML
H
EA
T
A
G
---
G
R
L
I
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|511693.5.peg.259
Escherichia coli BL21 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
M
A
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
P
T
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
ML
H
EA
T
A
G
---
G
R
L
I
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|469008.4.peg.3485
Escherichia coli BL21(DE3) (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
M
A
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
P
T
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
ML
H
EA
T
A
G
---
G
R
L
I
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|679205.4.peg.3941
Escherichia coli MS 124-1 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--GTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
P
T
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
H
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
ML
H
EA
T
A
G
---
G
R
L
I
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|749533.3.peg.119
Escherichia coli MS 84-1 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
A
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--GTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
P
T
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
H
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
ML
H
EA
T
A
G
---
G
R
L
I
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|358709.5.peg.2874
Escherichia coli 101-1 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
M
A
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
TS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
P
T
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESR
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
ML
H
EA
T
A
G
---
G
R
L
I
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|478007.5.peg.2520
Escherichia coli O157:H7 str. EC508 (24-737/741)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVL
P
VI
-
----
---
---
TA
S
N
A
GA
L
SKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
QARAAASLV
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
S
QP
P
-------------------------------------
E
--DTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
I
D
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
K
S
GAR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
IL
H
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
fig|550676.3.peg.1061
Escherichia coli B185 (24-728/732)
R
I
D
G
PL
K
T
TG
T
ARY
AY
E
W
HEE
S
P
N
A
A
Y
G
Y
I
V
G
S
A
IA
K
G
RL
T
A
LD
TDA
A
Q
K
A
PGVLAVI
-
----
---
---
TA
S
N
A
GA
L
GKG
D
K
N
TA
-
R
L
L
G
G
PT
I
E
H
Y
HQ
A
I
A
L
VVAE
T
F
E
---------
Q
A
RA
AA
S
LV
QA
H
Y
R
R
-
---NKGAY
S
LA
DEK
QA
V
N
QP
P
-------------------------------------
E
--GTPDK
N
V
GD
F
D
GA
F
--
SS
A
A
V
K
I
D
A
TY
T
TP
DQ
S
H
M
A
ME
P
H
A
S
M
A
V
W
--
DG
N
K
LT
L
W
T
S
N
Q
M
I
DWC
R
T
D
L
A
K
T
L
K
V
P
VEN
VR
I
I
S
P
Y
I
GGGFG
G
K
LF
L
R
S
D
A
L
L
A
A
L
A
ARAV
K
RPVKV
M
L
P
R
PS
I
P
N
N
TT
H
R
P
A
TLQHL
RI
GA
D
Q
S
G
K
I
TA
I
SH
ESW
S
G
N
LPG
G
T
P
E
T
A
V
Q
QSE
L
LY
AG
A
N
RHTG
L
--
--------R
L
A
T
L
D
LP
EG
N
AMR
AP
G
EA
P
G
L
M
A
L
E
I
A
I
DELAE
K
A
GIDPVE
F
R
I
L
N
DTQ
VD
P
-----------
A
D
P
--TRRFS
R
RQ
L
I
ECLR
T
G
A
D
K
F
G
W
KQ
R
N
A
----
T
P
G
QV
R
D
G
-----------
E
W
L
VG
H
GVA
AGFRNN
---
L
L
E
E
S
E
AR
V
H
LE
P
N
GT
VT
V
E
TD
M
TDIGTG
S
Y
T
I
L
A
Q
T
AAE
M
LGVP
LE
Q
V
-
AVH
L
GD
SS
F-
P
VS
A
G
S
G
GQ
W
G
A
NT
S
TS
G
V
Y
A
A
C
VK
LRE
M
I
AS
A
V
G
F
DP
E
QS
----
Q
F
A
D
G
K
I
T
N
G
T
R
S
A
---
-
-
--
-
-
-
--
TL
N
EA
T
A
G
---
G
R
L
T
AE
E
SI
E
F
G
T
LSKEY
QQST
F
A
GH
FVEV
G
V
H
S
ATGEVR
V
R
R
M
LAV
C
A
A
G
R
ILNP
K
T
A
R
S
QV
I
GAM
T
MG
M
G
A
AL
M
EE
L
A
V
D
D
R
L
G
YFV
N
H
D
M
AG
Y
EV
P
VHA
DIP
K
Q
E
V
I
FL
DD
T
DP
IS
SP
M
K
AK
G
V
GE
L
G
L
C
GV
S
AAIANAV
YN
ATGI
R
V
R
DY
P
I
T
L
D
KL
LDKL
Consen1
Primary consensus
MEAREATATGkhymr
Da
kvtg
arY
d
--
v
a
acy
k
vrSpiAhg
t
ld
Ar
lPGVlavit
pdi
tag
a
l
k
dtadR
l
g
vrH
gdavA
VVAe
ee
---------
A
Aa
Lv
eye
l
alAeda
vh
p
-------------------------------------
n
h
Gd
d
f
--
Adv
iq
tY
tp
qhc
mE
h
s
a
w
--
Dgsrlti
sStQip
Rr
vaq
l
ip
VrvIkp
vGGGFG
Kqdvl
e
m
A
lt
grPVkv
l
Ree
f
att
Rha
kmGa
rdG
lta
--
s
d
nTg
ya
h
i
aG
n
Lyp
t
y
nlp
gAmrgyGap
g
fAve
aldelAe
lgIDpvEir
rN
eg
-----------
a
P
s
L
EcLr
Grk
f
W
r
a
----
q
G
r
g
-----------
W
vG
gva
---
ve
agarl
le
dGT
V
sg
tdIGtG
dTv
sq
aAE
lgvP
dV
vis
gDtd
pfd
Ga
as
gs
s
a
r
Aa
LrEkI
h
a
ml
qs
qla
g
iv
g
r
e
---
s
d
a
--
h
e
G
---
G
L
ae
Si
t
t
-----
fg
Fvev
Vd
atgevri
r
lav
d
G
ilNP
lA
gQv
Gam
mgiG
al
EEmi
Dak
G
n
dl
Y
P
DiPq
e
afl
ndp
sp
gaKslgE
gi
gvaaAIanAv
AtGi
ir
p
TpkklyeefHLAGLI
Consen2
Secondary consensus
escpk
g
mtqa
pc
e
hee
p
mav
y
lg
ah
ka
v
in
a
vhif
-
---
pgs
s
-
pl
-
m
t
e
hqri
r
fl
l
i
hw
-
sm
dek
i
gvvyvagapdtleddnshaaqrgehmiinfpigsrprke
n
q
i
ay
v
h
st
sqm
t
v
c
t
mme
d
kivl
n
i
t
lg
v
k
hi
se
i
lf
r
d
aa
ki
lf
y
ps
p
nnr
pv
v
s
i
--
sh
k
n
g
p
tg
q
n
a
--
l
t
dic
n
yqap
ea
v
m
t
miada
t
aq
ql
fi
l
vd
elkilgaigegk
r
i
e
a
i
p
pecqnt
-
-
vgvacfsytsn
i
---
gip
d
sncm
mn
n
td
ae
q
y
i
k
v
vhc
q
avh
q
ss
lvs
s
gq
q
a
g
y
c
k
m
a
g
dp
ep
tfi
p
vt
v
k
aepl
-
-
-
md
y
t
tgf
gt
y
f
dlskey
ya
adl
rlckit
k
ynl
a
pv
t
s
i
gt
ram
sm
a
d
t
nm
l
f
ivv
ed
ga
kh
g
s
p
pasp
rt
i
c
v
n
h
l
rildkl
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character