fig|216592.1.peg.2545
Escherichia coli 042 (303-1372/1372)
MQ
D
D
F
D
A
PV
DFVSGLGP-
-
L
N
W
T
YD
KT
S
G
T
GTL
S
QG
SKN
W
T
MHG
QKDN
----
DLN
A
GKNL
V
F
S
G
Q
NG
A
I
I
LKD
S
V
T
QGAG
Y
L
E
F
KD
S
YTV
SAESGK
-
TW
T
GAGII
T
D
K
G
TN
V
T
W
K
VNGV
A
GDNLHK
L
G
E
GTL
T
I
N
GTG
V
N
P
GGLK
T
GDG
I
VVLNQQAD
TA
G
NI
QAFS
S
V
N
L
ASGRPTVVL
G
D
AR
QVNPD
N
---
I
S
WGYRGG
K
LDLNGN
A
V
TF
T
RL
Q
AAD
Y
GA
V
I
T
--
N
-
N
AQQK
S
Q
L
L
LD
LKA-QDTNV
S
E
P
T
IGNISP
-
-
--
FGGT
GT
P
G
N
LY
SMI
--
LNSQTRFY
ILK
SAS
YG
NTL
WG
NSLNDPAQ
W
EF
VG
MDKNK
A
VQTVKDRI
L
A
G
RAKQPV
IFHG
Q
L
T
GNM
D
VA
-
-IPQVPGGRKVI
F
DGS
V
N
L
P
E
GT
L
S
Q
D
S
G
T
L
IF
QGHPVIHA
S
--------------------------
I
S
G
S
A
-
------
--
-
----
-
P
V
S
L
N
Q
K
DWENR
Q
F
TMKT
L
S
L
K
DA
D
F
H
L
S
RNA
S
L
NSD
I
K
S
D
N
-
S
H
I
T
LGS
DR
A
F
V
D
K
NDG
T
G
------
NYVIPE
EG
T
S
V
P
DTVN
D
R
S
Q
Y
E
G
N
I
T
L
NHN
S
A
L
D
I
-
GSR
F
T
GGI
D
A
Y
D
-
S
A
V
S
I
T
S
P
DV
L
L
TAP
G
A
F
AG
-
SSLT
V
H
DG
G
HLT
A
LN
GL
F
SDG
H
I
QAGKNGK
I
T
L
SGT
P
VKDTANQYAPAVYLTD-GYD
L
T
G
DNAA
L
EITRGAHAS
GDI
HASAA
-
ST
-
VTI
G
SDTPAE-
----------
LASAETAA
S
AFAGS
L
L
-
EGYNAAFN
G
A
I
T
------
G
GR
A
D
VSM
H
N
A
L
--
W
T
L
G
G
D
S
AIHS
L
TVRN
S
RISSEG
--
-DRTFRT
LT
VNKLDATG
S
D
FV
L
R
TD
LKN
AD
K
I
N
V
T
E
K
A
T
G
S
DN
S
L
N
V
S
F
MNNPAQGQAL
NI
P
LVTAP
AG
T
SA
E
M
--
F
KAG
TR
VT
GFS
RV
TP
T
L
HVDTSG
-------------------------------------------------------------------------------
GN
TKW
I
L
D
G
F
KAEA
D
KAAAAK
A
DS
FMN
AG
Y
K
NF
M
TEVNNLN
K
RMGDLRD
T
N
G
D
AGAWARI
M
SG
A
GSA
D
GG
Y
SDNYTHVQVG
F
D
---
K
KH
E
L
D
G
V
DLFTGVT
M
TYTDS
S
A
DSHA
FSGKTKS
V
G
-----
G
G
L
YAS
A
LF
E
SG
--
AY
I
DLIGKYIHHDN
D
Y
TGNF
A
S
L
G
T
K
H
Y
N
T
HSWYAGAE
T
GYRYHL
T
--
ED
TFIEPQAELVYG
A
VSG
KT
F
R
W
KDG
D
M
D
LSMK
NRDFS
PL
V
GRTGV
EL
GKTFSGKDW
S
VTA
R
AG
TS
W
QFDL
LNNGE
T
V
LRD
A
SGE
KR
I
K
G
E
KDSRML
FN
VG
M
NA
Q
IK
DN
M
R
F
GLE
F
EKSAFGKYN
V
D
N
A
V
NAN
F
RY
M
F
fig|1040638.4.peg.2520
Escherichia coli O104:H4 str. LB226692
MQ
D
D
F
D
A
PV
DFVSGLGP-
-
L
N
W
T
YD
KT
S
G
T
GTL
S
QG
SKN
W
T
MHG
QKDN
----
DLN
A
GKNL
V
F
S
G
Q
NG
A
I
I
LKD
S
V
T
QGAG
Y
L
E
F
KD
S
YTV
SAESGK
-
TW
T
GAGII
T
D
K
G
TN
V
T
W
K
VNGV
A
GDNLHK
L
G
E
GTL
T
I
N
GTG
V
N
P
GGLK
T
GDG
I
VVLNQQAD
TA
G
NI
QAFS
S
V
N
L
ASGRPTVVL
G
D
AR
QVNPD
N
---
I
S
WGYRGG
K
LDLNGN
A
V
TF
T
RL
Q
AAD
Y
GA
V
I
T
--
N
-
N
AQQK
S
Q
L
L
LD
LKA-QDTNV
S
E
P
T
IGNISP
-
-
--
FGGT
GT
P
G
N
LY
SMI
--
LNSQTRFY
ILK
SAS
YG
NTL
WG
NSLNDPAQ
W
EF
VG
MNKNK
A
VQTVKDRI
L
A
G
RAKQPV
IFHG
Q
L
T
GNM
D
VA
-
-IPQVPGGRKVI
F
DGS
V
N
L
P
E
GT
L
S
Q
D
S
G
T
L
IF
QGHPVIHA
S
--------------------------
I
S
G
S
A
-
------
--
-
----
-
P
V
S
L
N
Q
K
DWENR
Q
F
TMKT
L
S
L
K
DA
D
F
H
L
S
RNA
S
L
NSD
I
K
S
D
N
-
S
H
I
T
LGS
DR
A
F
V
D
K
NDG
T
G
------
NYVIPE
EG
T
S
V
P
DTVN
D
R
S
Q
Y
E
G
N
I
T
L
NHN
S
A
L
D
I
-
GSR
F
T
GGI
D
A
Y
D
-
S
A
V
S
I
T
S
P
DV
L
L
TAP
G
A
F
AG
-
SSLT
V
H
DG
G
HLT
A
LN
GL
F
SDG
H
I
QAGKNGK
I
T
L
SGT
P
VKDTANQYAPAVYLTD-GYD
L
T
G
DNAA
L
EITRGAHAS
GDI
HASAA
-
ST
-
VTI
G
SDTPAE-
----------
LASAETAA
S
AFAGS
L
L
-
EGYNAAFN
G
A
I
T
------
G
GR
A
D
VSM
H
N
A
L
--
W
T
L
G
G
D
S
AIHS
L
TVRN
S
RISSEG
--
-DRTFRT
LT
VNKLDATG
S
D
FV
L
R
TD
LKN
AD
K
I
N
V
T
E
K
A
T
G
S
DN
S
L
N
V
S
F
MNNPAQGQAL
NI
P
LVTAP
AG
T
SA
E
M
--
F
KAG
TR
VT
GFS
RV
TP
T
L
HVDTSG
-------------------------------------------------------------------------------
GN
TKW
I
L
D
G
F
KAEA
D
KAAAAK
A
DS
FMN
AG
Y
K
NF
M
TEVNNLN
K
RMGDLRD
T
N
G
D
AGAWARI
M
SG
A
GSA
D
GG
Y
SDNYTHVQVG
F
D
---
K
KH
E
L
D
G
V
DLFTGVT
M
TYTDS
S
A
DSHA
FSGKTKS
V
G
-----
G
G
L
YAS
A
LF
E
SG
--
AY
I
DLIGKYIHHDN
D
Y
TGNF
A
S
L
G
T
K
H
Y
N
T
HSWYAGAE
T
GYRYHL
T
--
ED
TFIEPQAELVYG
A
VSG
KT
F
R
W
KDG
D
M
D
LSMK
NRDFS
PL
V
GRTGV
EL
GKTFSGKDW
S
VTA
R
AG
TS
W
QFDL
LNNGE
T
V
LRD
A
SGE
KR
I
K
G
E
KDSRML
FN
VG
M
NA
Q
IK
DN
M
R
F
GLE
F
EKSAFGKYN
V
D
N
A
V
NAN
F
RY
M
F
fig|655817.3.peg.332
Escherichia coli ABU 83972 (303-1371/1371)
MQ
D
D
F
D
A
PV
DFVSGLPP-
-
L
N
W
T
YD
KT
S
G
T
GTL
S
QG
SKN
W
T
MHG
QKDN
----
DLN
A
GKNL
V
F
S
G
Q
NG
A
I
V
LKD
S
V
T
QGAG
Y
L
E
F
KD
S
YTV
SAESGK
-
TW
T
GAGII
T
D
K
G
TN
V
T
W
K
VNGV
A
GDNLHK
L
G
E
GTL
T
I
N
GTG
V
N
P
GGLK
T
GDGTVVLNQQAD
TA
G
NV
QAFS
S
V
N
L
ASGRPTVVL
G
D
AR
QVNPD
N
---
I
S
WGYRGG
K
LDLNGN
A
V
TF
T
RL
Q
AAD
Y
GA
V
I
T
--
N
-
N
AQQK
S
R
L
L
LD
LKA-QDTNV
SVP
-
IGSISP
-
-
--
FGGT
GT
P
G
N
LY
SMI
--
LNGQTRFY
ILK
SAS
YG
NTL
WG
NSLNDPAQ
W
EF
VG
TDKNK
A
VQTVKDRI
L
A
G
RAKQPV
IFHG
Q
L
T
GNM
D
VT
-
-IPQLPGGRKVI
L
DGS
V
N
L
P
E
GT
L
S
ED
S
G
T
L
IF
QGHPVIHA
S
--------------------------
V
S
G
S
A
-
------
--
-
----
-
P
V
S
L
N
Q
K
DWENR
Q
F
IMKT
L
S
L
K
DA
D
F
H
L
S
RNA
S
L
NSD
I
K
S
D
N
-
S
H
I
T
LGS
DR
VF
V
D
K
NDG
T
G
------
NYVILE
EG
T
S
V
P
DTVN
D
R
S
Q
Y
E
G
N
I
T
L
DHN
S
T
L
D
I
-
GSR
F
T
GGI
E
A
Y
D
-
S
A
V
S
I
T
S
P
DV
L
L
TAP
G
A
F
AG
-
SSLT
V
H
DG
G
HLT
A
LN
GL
F
SDG
H
I
QAGKNSK
I
T
L
SGT
P
VKDTANQYAPAVYLTD-GYD
L
T
G
DNAT
L
EITRGAHAS
GDI
HASAA
-
ST
-
VTI
G
SDTPAE-
----------
LASAETTA
S
AFAGS
L
L
-
EGYNAAFN
G
A
I
T
------
G
GR
A
D
VSM
H
N
A
L
--
W
T
L
G
G
D
S
AIHT
L
TVRN
S
RISSEG
--
-DRTFRT
LT
VNKLDATG
S
D
FV
L
R
TD
LKN
AD
K
I
N
V
T
E
K
A
T
G
S
DN
S
L
N
V
S
F
MKDPAQGQSL
NI
P
LVTAP
AG
T
SA
E
M
--
F
KAG
TR
MI
GFS
RV
TP
T
L
HVDTSG
-------------------------------------------------------------------------------
GN
TKW
I
L
D
G
F
KAEA
D
KAAAAK
A
DS
FMN
AG
Y
K
NF
M
TEVNNLN
K
RMGDLRD
T
N
G
D
AGAWARI
M
SG
A
GSA
D
GG
Y
SDNYTHVQVG
F
D
---
K
KH
E
L
D
G
V
DLFTGVT
M
TYTDS
S
A
DSHA
FSGKTKS
V
G
-----
G
G
L
YAS
A
LF
E
SG
--
AY
I
DLIGKYIHHDN
D
Y
TGNF
AG
L
G
T
K
H
Y
N
T
HSWYAGAE
T
GYRYHL
T
--
EE
TFIEPQAELVYG
A
VSG
KT
F
R
W
KDG
D
M
D
LSMK
NRDFS
PLIGRTG
I
EL
GKTFSGKDW
S
VTA
R
AG
TS
W
QFDL
LNNGE
T
V
LRD
A
SGE
KR
I
K
G
E
KDSRML
FN
VG
M
NA
Q
IK
DN
M
R
F
GLE
F
EKSAFGKYN
V
D
N
A
V
NAN
F
RY
M
F
fig|199310.1.peg.333
Escherichia coli CFT073 (303-1371/1371)
MQ
D
D
F
D
A
PV
DFVSGLPP-
-
L
N
W
T
YD
KT
S
G
T
GTL
S
QG
SKN
W
T
MHG
QKDN
----
DLN
A
GKNL
V
F
S
G
Q
NG
A
I
V
LKD
S
V
T
QGAG
Y
L
E
F
KD
S
YTV
SAESGK
-
TW
T
GAGII
T
D
K
G
TN
V
T
W
K
VNGV
A
GDNLHK
L
G
E
GTL
T
I
N
GTG
V
N
P
GGLK
T
GDGTVVLNQQAD
TA
G
NV
QAFS
S
V
N
L
ASGRPTVVL
G
D
AR
QVNPD
N
---
I
S
WGYRGG
K
LDLNGN
A
V
TF
T
RL
Q
AAD
Y
GA
V
I
T
--
N
-
N
AQQK
S
R
L
L
LD
LKA-QDTNV
SVP
-
IGSISP
-
-
--
FGGT
GT
P
G
N
LY
SMI
--
LNGQTRFY
ILK
SAS
YG
NTL
WG
NSLNDPAQ
W
EF
VG
TDKNK
A
VQTVKDRI
L
A
G
RAKQPV
IFHG
Q
L
T
GNM
D
VT
-
-IPQLPGGRKVI
L
DGS
V
N
L
P
E
GT
L
S
ED
S
G
T
L
IF
QGHPVIHA
S
--------------------------
V
S
G
S
A
-
------
--
-
----
-
P
V
S
L
N
Q
K
DWENR
Q
F
IMKT
L
S
L
K
DA
D
F
H
L
S
RNA
S
L
NSD
I
K
S
D
N
-
S
H
I
T
LGS
DR
VF
V
D
K
NDG
T
G
------
NYVILE
EG
T
S
V
P
DTVN
D
R
S
Q
Y
E
G
N
I
T
L
DHN
S
T
L
D
I
-
GSR
F
T
GGI
E
A
Y
D
-
S
A
V
S
I
T
S
P
DV
L
L
TAP
G
A
F
AG
-
SSLT
V
H
DG
G
HLT
A
LN
GL
F
SDG
H
I
QAGKNSK
I
T
L
SGT
P
VKDTANQYAPAVYLTD-GYD
L
T
G
DNAT
L
EITRGAHAS
GDI
HASAA
-
ST
-
VTI
G
SDTPAE-
----------
LASAETTA
S
AFAGS
L
L
-
EGYNAAFN
G
A
I
T
------
G
GR
A
D
VSM
H
N
A
L
--
W
T
L
G
G
D
S
AIHT
L
TVRN
S
RISSEG
--
-DRTFRT
LT
VNKLDATG
S
D
FV
L
R
TD
LKN
AD
K
I
N
V
T
E
K
A
T
G
S
DN
S
L
N
V
S
F
MKDPAQGQSL
NI
P
LVTAP
AG
T
SA
E
M
--
F
KAG
TR
MI
GFS
RV
TP
T
L
HVDTSG
-------------------------------------------------------------------------------
GN
TKW
I
L
D
G
F
KAEA
D
KAAAAK
A
DS
FMN
AG
Y
K
NF
M
TEVNNLN
K
RMGDLRD
T
N
G
D
AGAWARI
M
SG
A
GSA
D
GG
Y
SDNYTHVQVG
F
D
---
K
KH
E
L
D
G
V
DLFTGVT
M
TYTDS
S
A
DSHA
FSGKTKS
V
G
-----
G
G
L
YAS
A
LF
E
SG
--
AY
I
DLIGKYIHHDN
D
Y
TGNF
AG
L
G
T
K
H
Y
N
T
HSWYAGAE
T
GYRYHL
T
--
EE
TFIEPQAELVYG
A
VSG
KT
F
R
W
KDG
D
M
D
LSMK
NRDFS
PLIGRTG
I
EL
GKTFSGKDW
S
VTA
R
AG
TS
W
QFDL
LNNGE
T
V
LRD
A
SGE
KR
I
K
G
E
KDSRML
FN
VG
M
NA
Q
IK
DN
M
R
F
GLE
F
EKSAFGKYN
V
D
N
A
V
NAN
F
RY
M
F
fig|656440.3.peg.100
Escherichia coli TA206 (42-1110/1110)
MQ
D
D
F
D
A
PV
DFVSGLPP-
-
L
N
W
T
YD
KT
S
G
T
GTL
S
QG
SKN
W
T
MHG
QKDN
----
DLN
A
GKNL
V
F
S
G
Q
NG
A
I
V
LKD
S
V
T
QGAG
Y
L
E
F
KD
S
YTV
SAESGK
-
TW
T
GAGII
T
D
K
G
TN
V
T
W
K
VNGV
A
GDNLHK
L
G
E
GTL
T
I
N
GTG
V
N
P
GGLK
T
GDGTVVLNQQAD
TA
G
NV
QAFS
S
V
N
L
ASGRPTVVL
G
D
AR
QVNPD
N
---
I
S
WGYRGG
K
LDLNGN
A
V
TF
T
RL
Q
AAD
Y
GA
V
I
T
--
N
-
N
AQQK
S
R
L
L
LD
LKA-QDTNV
SVP
-
IGSISP
-
-
--
FGGT
GT
P
G
N
LY
SMI
--
LNGQTRFY
ILK
SAS
YG
NTL
WG
NSLNDPAQ
W
EF
VG
MDKNK
A
VQTVKDRI
L
A
G
RAKQPV
IFHG
Q
L
T
GNM
D
VT
-
-IPQLPGGRKVI
L
DGS
V
N
L
P
E
GT
L
S
ED
S
G
T
L
IF
QGHPVIHA
S
--------------------------
V
S
G
S
A
-
------
--
-
----
-
P
V
S
L
N
Q
K
DWENR
Q
F
IMKT
L
S
L
K
DA
D
F
H
L
S
RNA
S
L
NSD
I
K
S
D
N
-
S
H
I
T
LGS
DR
VF
V
D
K
NDG
T
G
------
NYVILE
EG
T
S
V
P
DTVN
D
R
S
Q
Y
E
G
N
I
T
L
DHN
S
T
L
D
I
-
GSR
F
T
GGI
E
A
Y
D
-
S
A
V
S
I
T
S
P
DV
L
L
TAP
G
A
F
AG
-
SSLT
V
H
DG
G
HLT
A
LN
GL
F
SDG
H
I
QAGKNSK
I
T
L
SGT
P
VKDTANQYAPAVYLTD-GYD
L
T
G
DNAT
L
EITRGAHAS
GDI
HASAA
-
ST
-
VTI
G
SDTPAE-
----------
LASAETTA
S
AFAGS
L
L
-
EGYNAAFN
G
A
I
T
------
G
GR
A
D
VSM
H
N
A
L
--
W
T
L
G
G
D
S
AIHT
L
TVRN
S
RISSEG
--
-DRTFRT
LT
VNKLDATG
S
D
FV
L
R
TD
LKN
AD
K
I
N
V
T
E
K
A
T
G
S
DN
S
L
N
V
S
F
MKDPAQGQSL
NI
P
LVTAP
AG
T
SA
E
M
--
F
KAG
TR
MI
GFS
RV
TP
T
L
HVDTSG
-------------------------------------------------------------------------------
GN
TKW
I
L
D
G
F
KAEA
D
KAAAAK
A
DS
FMN
AG
Y
K
NF
M
TEVNNLN
K
RMGDLRD
T
N
G
D
AGAWARI
M
SG
A
GSA
D
GG
Y
SDNYTHVQVG
F
D
---
K
KH
E
L
D
G
V
DLFTGVT
M
TYTDS
S
A
DSHA
FSGKTKS
V
G
-----
G
G
L
YAS
A
LF
E
SG
--
AY
I
DLIGKYIHHDN
D
Y
TGNF
AG
L
G
T
K
H
Y
N
T
HSWYAGAE
T
GYRYHL
T
--
EE
TFIEPQAELVYG
A
VSG
KT
F
R
W
KDG
D
M
D
LSMK
NRDFS
PLIGRTG
I
EL
GKTFSGKDW
S
VTA
R
AG
TS
W
QFDL
LNNGE
T
V
LRD
A
SGE
KR
I
K
G
E
KDSRML
FN
VG
M
NA
Q
IK
DN
M
R
F
GLE
F
EKSAFGKYN
V
D
N
A
V
NAN
F
RY
M
F
fig|525281.3.peg.2675
Escherichia coli 83972 (42-1110/1110)
MQ
D
D
F
D
A
PV
DFVSGLPP-
-
L
N
W
T
YD
KT
S
G
T
GTL
S
QG
SKN
W
T
MHG
QKDN
----
DLN
A
GKNL
V
F
S
G
Q
NG
A
I
V
LKD
S
V
T
QGAG
Y
L
E
F
KD
S
YTV
SAESGK
-
TW
T
GAGII
T
D
K
G
TN
V
T
W
K
VNGV
A
GDNLHK
L
G
E
GTL
T
I
N
GTG
V
N
P
GGLK
T
GDGTVVLNQQAD
TA
G
NV
QAFS
S
V
N
L
ASGRPTVVL
G
D
AR
QVNPD
N
---
I
S
WGYRGG
K
LDLNGN
A
V
TF
T
RL
Q
AAD
Y
GA
V
I
T
--
N
-
N
AQQK
S
R
L
L
LD
LKA-QDTNV
SVP
-
IGSISP
-
-
--
FGGT
GT
P
G
N
LY
SMI
--
LNGQTRFY
ILK
SAS
YG
NTL
WG
NSLNDPAQ
W
EF
VG
TDKNK
A
VQTVKDRI
L
A
G
RAKQPV
IFHG
Q
L
T
GNM
D
VT
-
-IPQLPGGRKVI
L
DGS
V
N
L
P
E
GT
L
S
ED
S
G
T
L
IF
QGHPVIHA
S
--------------------------
V
S
G
S
A
-
------
--
-
----
-
P
V
S
L
N
Q
K
DWENR
Q
F
IMKT
L
S
L
K
DA
D
F
H
L
S
RNA
S
L
NSD
I
K
S
D
N
-
S
H
I
T
LGS
DR
VF
V
D
K
NDG
T
G
------
NYVILE
EG
T
S
V
P
DTVN
D
R
S
Q
Y
E
G
N
I
T
L
DHN
S
T
L
D
I
-
GSR
F
T
GGI
E
A
Y
D
-
S
A
V
S
I
T
S
P
DV
L
L
TAP
G
A
F
AG
-
SSLT
V
H
DG
G
HLT
A
LN
GL
F
SDG
H
I
QAGKNSK
I
T
L
SGT
P
VKDTANQYAPAVYLTD-GYD
L
T
G
DNAT
L
EITRGAHAS
GDI
HASAA
-
ST
-
VTI
G
SDTPAE-
----------
LASAETTA
S
AFAGS
L
L
-
EGYNAAFN
G
A
I
T
------
G
GR
A
D
VSM
H
N
A
L
--
W
T
L
G
G
D
S
AIHT
L
TVRN
S
RISSEG
--
-DRTFRT
LT
VNKLDATG
S
D
FV
L
R
TD
LKN
AD
K
I
N
V
T
E
K
A
T
G
S
DN
S
L
N
V
S
F
MKDPAQGQSL
NI
P
LVTAP
AG
T
SA
E
M
--
F
KAG
TR
MI
GFS
RV
TP
T
L
HVDTSG
-------------------------------------------------------------------------------
GN
TKW
I
L
D
G
F
KAEA
D
KAAAAK
A
DS
FMN
AG
Y
K
NF
M
TEVNNLN
K
RMGDLRD
T
N
G
D
AGAWARI
M
SG
A
GSA
D
GG
Y
SDNYTHVQVG
F
D
---
K
KH
E
L
D
G
V
DLFTGVT
M
TYTDS
S
A
DSHA
FSGKTKS
V
G
-----
G
G
L
YAS
A
LF
E
SG
--
AY
I
DLIGKYIHHDN
D
Y
TGNF
AG
L
G
T
K
H
Y
N
T
HSWYAGAE
T
GYRYHL
T
--
EE
TFIEPQAELVYG
A
VSG
KT
F
R
W
KDG
D
M
D
LSMK
NRDFS
PLIGRTG
I
EL
GKTFSGKDW
S
VTA
R
AG
TS
W
QFDL
LNNGE
T
V
LRD
A
SGE
KR
I
K
G
E
KDSRML
FN
VG
M
NA
Q
IK
DN
M
R
F
GLE
F
EKSAFGKYN
V
D
N
A
V
NAN
F
RY
M
F
fig|199310.4.peg.328
Escherichia coli CFT073 (42-1110/1110)
MQ
D
D
F
D
A
PV
DFVSGLPP-
-
L
N
W
T
YD
KT
S
G
T
GTL
S
QG
SKN
W
T
MHG
QKDN
----
DLN
A
GKNL
V
F
S
G
Q
NG
A
I
V
LKD
S
V
T
QGAG
Y
L
E
F
KD
S
YTV
SAESGK
-
TW
T
GAGII
T
D
K
G
TN
V
T
W
K
VNGV
A
GDNLHK
L
G
E
GTL
T
I
N
GTG
V
N
P
GGLK
T
GDGTVVLNQQAD
TA
G
NV
QAFS
S
V
N
L
ASGRPTVVL
G
D
AR
QVNPD
N
---
I
S
WGYRGG
K
LDLNGN
A
V
TF
T
RL
Q
AAD
Y
GA
V
I
T
--
N
-
N
AQQK
S
R
L
L
LD
LKA-QDTNV
SVP
-
IGSISP
-
-
--
FGGT
GT
P
G
N
LY
SMI
--
LNGQTRFY
ILK
SAS
YG
NTL
WG
NSLNDPAQ
W
EF
VG
TDKNK
A
VQTVKDRI
L
A
G
RAKQPV
IFHG
Q
L
T
GNM
D
VT
-
-IPQLPGGRKVI
L
DGS
V
N
L
P
E
GT
L
S
ED
S
G
T
L
IF
QGHPVIHA
S
--------------------------
V
S
G
S
A
-
------
--
-
----
-
P
V
S
L
N
Q
K
DWENR
Q
F
IMKT
L
S
L
K
DA
D
F
H
L
S
RNA
S
L
NSD
I
K
S
D
N
-
S
H
I
T
LGS
DR
VF
V
D
K
NDG
T
G
------
NYVILE
EG
T
S
V
P
DTVN
D
R
S
Q
Y
E
G
N
I
T
L
DHN
S
T
L
D
I
-
GSR
F
T
GGI
E
A
Y
D
-
S
A
V
S
I
T
S
P
DV
L
L
TAP
G
A
F
AG
-
SSLT
V
H
DG
G
HLT
A
LN
GL
F
SDG
H
I
QAGKNSK
I
T
L
SGT
P
VKDTANQYAPAVYLTD-GYD
L
T
G
DNAT
L
EITRGAHAS
GDI
HASAA
-
ST
-
VTI
G
SDTPAE-
----------
LASAETTA
S
AFAGS
L
L
-
EGYNAAFN
G
A
I
T
------
G
GR
A
D
VSM
H
N
A
L
--
W
T
L
G
G
D
S
AIHT
L
TVRN
S
RISSEG
--
-DRTFRT
LT
VNKLDATG
S
D
FV
L
R
TD
LKN
AD
K
I
N
V
T
E
K
A
T
G
S
DN
S
L
N
V
S
F
MKDPAQGQSL
NI
P
LVTAP
AG
T
SA
E
M
--
F
KAG
TR
MI
GFS
RV
TP
T
L
HVDTSG
-------------------------------------------------------------------------------
GN
TKW
I
L
D
G
F
KAEA
D
KAAAAK
A
DS
FMN
AG
Y
K
NF
M
TEVNNLN
K
RMGDLRD
T
N
G
D
AGAWARI
M
SG
A
GSA
D
GG
Y
SDNYTHVQVG
F
D
---
K
KH
E
L
D
G
V
DLFTGVT
M
TYTDS
S
A
DSHA
FSGKTKS
V
G
-----
G
G
L
YAS
A
LF
E
SG
--
AY
I
DLIGKYIHHDN
D
Y
TGNF
AG
L
G
T
K
H
Y
N
T
HSWYAGAE
T
GYRYHL
T
--
EE
TFIEPQAELVYG
A
VSG
KT
F
R
W
KDG
D
M
D
LSMK
NRDFS
PLIGRTG
I
EL
GKTFSGKDW
S
VTA
R
AG
TS
W
QFDL
LNNGE
T
V
LRD
A
SGE
KR
I
K
G
E
KDSRML
FN
VG
M
NA
Q
IK
DN
M
R
F
GLE
F
EKSAFGKYN
V
D
N
A
V
NAN
F
RY
M
F
fig|656393.3.peg.873
Escherichia coli H299 (42-1110/1110)
MQ
D
D
F
D
A
PV
DFVSGLPP-
-
L
N
W
T
YD
KT
S
G
T
GTL
S
QG
SKN
W
T
MHG
QKDN
----
DLN
A
GKNL
V
F
S
G
Q
NG
A
I
V
LKD
S
V
T
QGAG
Y
L
E
F
KD
S
YTV
SAESGK
-
TW
T
GAGII
T
D
K
G
TN
V
T
W
K
VNGV
A
GDNLHK
L
G
E
GTL
T
I
N
GTG
V
N
P
GGLK
T
GDGTVVLNQQAD
TA
G
NV
QAFS
S
V
N
L
ASGRPTVVL
G
D
AR
QVNPD
N
---
I
S
WGYRGG
K
LDLNGN
A
V
TF
T
RL
Q
AAD
Y
GA
V
I
T
--
N
-
N
AQQK
S
R
L
L
LD
LKA-QDTNV
SVP
-
IGSISP
-
-
--
FGGT
GT
P
G
N
LY
SMI
--
LNGQTRFY
ILK
SAS
YG
NTL
WG
NSLNDPAQ
W
EF
VG
TDKNK
A
VQTVKDRI
L
A
G
RAKQPV
IFHG
Q
L
T
GNM
D
VT
-
-IPQLPGGRKVI
L
DGS
V
N
L
P
E
GT
L
S
ED
S
G
T
L
IF
QGHPVIHA
S
--------------------------
V
S
G
S
A
-
------
--
-
----
-
P
V
S
L
N
Q
K
DWENR
Q
F
IMKT
L
S
L
K
DA
D
F
H
L
S
RNA
S
L
NSD
I
K
S
D
N
-
S
H
I
T
LGS
DR
VF
V
D
K
NDG
T
G
------
NYVILE
EG
T
S
V
P
DTVN
D
R
S
Q
Y
E
G
N
I
T
L
DHN
S
T
L
D
I
-
GSR
F
T
GGI
E
A
Y
D
-
S
A
V
S
I
T
S
P
DV
L
L
TAP
G
A
F
AG
-
SSLT
V
H
DG
G
HLT
A
LN
GL
F
SDG
H
I
QAGKNSK
I
T
L
SGT
P
VKDTANQYAPAVYLTD-GYD
L
T
G
DNAT
L
EITRGAHAS
GDI
HASAA
-
ST
-
VTI
G
SDTPAE-
----------
LASAETTA
S
AFAGS
L
L
-
EGYNAAFN
G
A
I
T
------
G
GR
A
D
VSM
H
N
A
L
--
W
T
L
G
G
D
S
AIHT
L
TVRN
S
RISSEG
--
-DRTFRT
LT
VNKLDATG
S
D
FV
L
R
TD
LKN
AD
K
I
N
V
T
E
K
A
T
G
S
DN
S
L
N
V
S
F
MKDPAQGQSL
NI
P
LVTAP
AG
T
SA
E
M
--
F
KAG
TR
MI
GFS
RV
TP
T
L
HVDTSG
-------------------------------------------------------------------------------
GN
TKW
I
L
D
G
F
KAEA
D
KAAAAK
A
DS
FMN
AG
Y
K
NF
M
TEVNNLN
K
RMGDLRD
T
N
G
D
AGAWARI
M
SG
A
GSA
D
GG
Y
SDNYTHVQVG
F
D
---
K
KH
E
L
D
G
V
DLFTGVT
M
TYTDS
S
A
DSHA
FSGKTKS
V
G
-----
G
G
L
YAS
A
LF
E
SG
--
AY
I
DLIGKYIHHDN
D
Y
TGNF
AG
L
G
T
K
H
Y
N
T
HSWYAGAE
T
GYRYHL
T
--
EE
TFIEPQAELVYG
A
VSG
KT
F
R
W
KDG
D
M
D
LSMK
NRDFS
PLIGRTG
I
EL
GKTFSGKDW
S
VTA
R
AG
TS
W
QFDL
LNNGE
T
V
LRD
A
SGE
KR
I
K
G
E
KDSRML
FN
VG
M
NA
Q
IK
DN
M
R
F
GLE
F
EKSAFGKYN
V
D
N
A
V
NAN
F
RY
M
F
fig|749528.3.peg.4087
Escherichia coli MS 45-1 (42-1110/1110)
MQ
D
D
F
D
A
PV
DFVSGLPP-
-
L
N
W
T
YD
KT
S
G
T
GTL
S
QG
SKN
W
T
MHG
QKDN
----
DLN
A
GKNL
V
F
S
G
Q
NG
A
I
V
LKD
S
V
T
QGAG
Y
L
E
F
KD
S
YTV
SAESGK
-
TW
T
GAGII
T
D
K
G
TN
V
T
W
K
VNGV
A
GDNLHK
L
G
E
GTL
T
I
N
GTG
V
N
P
GGLK
T
GDGTVVLNQQAD
TA
G
NV
QAFS
S
V
N
L
ASGRPTVVL
G
D
AR
QVNPD
N
---
I
S
WGYRGG
K
LDLNGN
A
V
TF
T
RL
Q
AAD
Y
GA
V
I
T
--
N
-
N
AQQK
S
R
L
L
LD
LKA-QDTNV
SVP
-
IGSISP
-
-
--
FGGT
GT
P
G
N
LY
SMI
--
LNGQTRFY
ILK
SAS
YG
NTL
WG
NSLNDPAQ
W
EF
VG
TDKNK
A
VQTVKDRI
L
A
G
RAKQPV
IFHG
Q
L
T
GNM
D
VT
-
-IPQLPGGRKVI
L
DGS
V
N
L
P
E
GT
L
S
ED
S
G
T
L
IF
QGHPVIHA
S
--------------------------
V
S
G
S
A
-
------
--
-
----
-
P
V
S
L
N
Q
K
DWENR
Q
F
IMKT
L
S
L
K
DA
D
F
H
L
S
RNA
S
L
NSD
I
K
S
D
N
-
S
H
I
T
LGS
DR
VF
V
D
K
NDG
T
G
------
NYVILE
EG
T
S
V
P
DTVN
D
R
S
Q
Y
E
G
N
I
T
L
DHN
S
T
L
D
I
-
GSR
F
T
GGI
E
A
Y
D
-
S
A
V
S
I
T
S
P
DV
L
L
TAP
G
A
F
AG
-
SSLT
V
H
DG
G
HLT
A
LN
GL
F
SDG
H
I
QAGKNSK
I
T
L
SGT
P
VKDTANQYAPAVYLTD-GYD
L
T
G
DNAT
L
EITRGAHAS
GDI
HASAA
-
ST
-
VTI
G
SDTPAE-
----------
LASAETTA
S
AFAGS
L
L
-
EGYNAAFN
G
A
I
T
------
G
GR
A
D
VSM
H
N
A
L
--
W
T
L
G
G
D
S
AIHT
L
TVRN
S
RISSEG
--
-DRTFRT
LT
VNKLDATG
S
D
FV
L
R
TD
LKN
AD
K
I
N
V
T
E
K
A
T
G
S
DN
S
L
N
V
S
F
MKDPAQGQSL
NI
P
LVTAP
AG
T
SA
E
M
--
F
KAG
TR
MI
GFS
RV
TP
T
L
HVDTSG
-------------------------------------------------------------------------------
GN
TKW
I
L
D
G
F
KAEA
D
KAAAAK
A
DS
FMN
AG
Y
K
NF
M
TEVNNLN
K
RMGDLRD
T
N
G
D
AGAWARI
M
SG
A
GSA
D
GG
Y
SDNYTHVQVG
F
D
---
K
KH
E
L
D
G
V
DLFTGVT
M
TYTDS
S
A
DSHA
FSGKTKS
V
G
-----
G
G
L
YAS
A
LF
E
SG
--
AY
I
DLIGKYIHHDN
D
Y
TGNF
AG
L
G
T
K
H
Y
N
T
HSWYAGAE
T
GYRYHL
T
--
EE
TFIEPQAELVYG
A
VSG
KT
F
R
W
KDG
D
M
D
LSMK
NRDFS
PLIGRTG
I
EL
GKTFSGKDW
S
VTA
R
AG
TS
W
QFDL
LNNGE
T
V
LRD
A
SGE
KR
I
K
G
E
KDSRML
FN
VG
M
NA
Q
IK
DN
M
R
F
GLE
F
EKSAFGKYN
V
D
N
A
V
NAN
F
RY
M
F
fig|749546.3.peg.3640
Escherichia coli MS 185-1 (42-1110/1110)
MQ
D
D
F
D
A
PV
DFVSGLPP-
-
L
N
W
T
YD
KT
S
G
T
GTL
S
QG
SKN
W
T
MHG
QKDN
----
DLN
A
GKNL
V
F
S
G
Q
NG
A
I
V
LKD
S
V
T
QGAG
Y
L
E
F
KD
S
YTV
SAESGK
-
TW
T
GAGII
T
D
K
G
TN
V
T
W
K
VNGV
A
GDNLHK
L
G
E
GTL
T
I
N
GTG
V
N
P
GGLK
T
GDGTVVLNQQAD
TA
G
NV
QAFS
S
V
N
L
ASGRPTVVL
G
D
AR
QVNPD
N
---
I
S
WGYRGG
K
LDLNGN
A
V
TF
T
RL
Q
AAD
Y
GA
V
I
T
--
N
-
N
AQQK
S
R
L
L
LD
LKA-QDTNV
SVP
-
IGSISP
-
-
--
FGGT
GT
P
G
N
LY
SMI
--
LNGQTRFY
ILK
SAS
YG
NTL
WG
NSLNDPAQ
W
EF
VG
TDKNK
A
VQTVKDRI
L
A
G
RAKQPV
IFHG
Q
L
T
GNM
D
VT
-
-IPQLPGGRKVI
L
DGS
V
N
L
P
E
GT
L
S
ED
S
G
T
L
IF
QGHPVIHA
S
--------------------------
V
S
G
S
A
-
------
--
-
----
-
P
V
S
L
N
Q
K
DWENR
Q
F
IMKT
L
S
L
K
DA
D
F
H
L
S
RNA
S
L
NSD
I
K
S
D
N
-
S
H
I
T
LGS
DR
VF
V
D
K
NDG
T
G
------
NYVILE
EG
T
S
V
P
DTVN
D
R
S
Q
Y
E
G
N
I
T
L
DHN
S
T
L
D
I
-
GSR
V
T
GG
G
E
A
Y
D
-
S
A
V
S
I
T
S
P
DV
L
L
TAP
G
A
F
AG
-
SSLT
V
H
DG
G
HLT
A
LN
GL
F
SDG
H
I
QAGKNSK
I
T
L
SGT
P
VKDTANQYAPAVYLTD-GYD
L
T
G
DNAT
L
EITRGAHAS
GDI
HASAA
-
ST
-
VTI
G
SDTPAE-
----------
LASAETTA
S
AFAGS
L
L
-
EGYNAAFN
G
A
I
T
------
G
GR
A
D
VSM
H
N
A
L
--
W
T
L
G
G
D
S
AIHT
L
TVRN
S
RISSEG
--
-DRTFRT
LT
VNKLDATG
S
D
FV
L
R
TD
LKN
AD
K
I
N
V
T
E
K
A
T
G
S
DN
S
L
N
V
S
F
MKDPAQGQSL
NI
P
LVTAP
AG
T
SA
E
M
--
F
KAG
TR
MI
GFS
RV
TP
T
L
HVDTSG
-------------------------------------------------------------------------------
GN
TKW
I
L
D
G
F
KAEA
D
KAAAAK
A
DS
FMN
AG
Y
K
NF
M
TEVNNLN
K
RMGDLRD
T
N
G
D
AGAWARI
M
SG
A
GSA
D
GG
Y
SDNYTHVQVG
F
D
---
K
KH
E
L
D
G
V
DLFTGVT
M
TYTDS
S
A
DSHA
FSGKTKS
V
G
-----
G
G
L
YAS
A
LF
E
SG
--
AY
I
DLIGKYIHHDN
D
Y
TGNF
AG
L
G
T
K
H
Y
N
T
HSWYAGAE
T
GYRYHL
T
--
EE
TFIEPQAELVYG
A
VSG
KT
F
R
W
KDG
D
M
D
LSMK
NRDFS
PLIGRTG
I
EL
GKTFSGKDW
S
VTA
R
AG
TS
W
QFDL
LNNGE
T
V
LRD
A
SGE
KR
I
K
G
E
KDSRML
FN
VG
M
NA
Q
IK
DN
M
R
F
GLE
F
EKSAFGKYN
V
D
N
A
V
NAN
F
RY
M
F
fig|340184.3.peg.4473
Escherichia coli B7A (313-1366/1366)
Q
N
D
F
D
K
TI
TYSAGAGA-
-
L
Q
W
K
YD
AV
N
G
T
G
S
L
T
QG
NTI
W
D
MHG
KKGN
----
DLN
A
GKNL
L
L
T
G
N
NG
E
V
V
L
Q
D
S
V
N
QGAG
Y
L
Q
F
AN
DY
K
V
SALNGQ
-
TW
M
G
G
G
V
I
T
D
K
G
TH
V
L
W
Q
VNGV
A
GDNLHK
L
G
E
GTL
M
V
N
GTG
V
N
A
GGLKVGDGTV
I
LNQQ
L
D
TD
G
KV
QAFS
S
V
D
I
S
SGRPTVVL
S
D
SR
QVNPD
N
---
I
S
WGYRGG
R
LDLNGN
N
LTF
T
R
I
Q
AAD
Y
GA
I
I
T
--
N
-
T
SEKK
S
T
V
T
LD
LQSLKASDI
N
VP
-
INTINF
-
-
--
LGGR
GT
P
G
D
LY
--L
--
VESTGQYY
ILK
ESS
Y
S
PFF
--
SDLNNPNI
W
QS
VG
KDRNK
A
IDTVKHQK
I
E
-
ASSQPY
MY
HG
Q
L
N
GNM
D
VN
-
-IPQLSGKDVLT
L
DGS
V
N
L
P
E
G
S
I
T
KK
S
G
T
L
IF
QGHP
I
IHA
G
--------------------------
T
T
T
S
A
-
------
--
-
----
-
-
-
-
-
S
Q
S
DWE
T
R
Q
F
TLGK
L
K
L
D
A
A
T
F
Y
L
S
RN
G
Q
M
HGD
I
N
A
V
N
G
S
T
V
I
LGS
DH
VF
T
D
K
NDG
T
G
------
NSVSSV
EG
T
A
T
A
TTTV
D
Q
S
D
Y
R
G
N
L
T
L
ENK
S
S
L
Q
I
-
REK
F
T
GGI
E
A
Y
D
-
S
S
V
S
V
N
S
Q
N
V
I
F
DRV
G
S
F
VN
-
SSL
S
L
E
KW
A
SLT
A
QS
G
I
F
S
T
G
V
V
DLKGNAS
L
T
L
TGI
P
SAEKHSYYSPVVSIIE-GIN
L
-
G
SQSS
L
TVENMGYLN
S
DI
MAENE
-
AM
-
VNL
G
-DSGAE-
----------
TGKTD---
S
PLFIS
L
M
-
KGYNAVLS
G
N
I
T
------
G
AK
S
I
V
N
M
N
N
S
L
--
W
C
I
T
G
N
S
TTGM
L
NARN
S
RVEVGN
--
-GKNFAN
L
Q
VKELVADN
S
T
F
L
M
H
T
N
NSQ
AD
H
L
N
V
T
D
K
L
S
G
S
R
N
T
I
L
V
N
F
LNNPANG--M
N
V
T
L
I
TAP
KG
S
NE
K
M
--
F
QAG
T
Q
QI
GFS
NV
TP
V
I
SAEKTD
-------------------------------------------------------------------------------
SS
TKW
V
L
T
GY
QTVS
D
VRTSKI
A
TD
FM
A
SG
Y
K
S
F
L
R
EVNNLN
K
RMGDLRD
T
Q
G
DT
G
V
W
G
RI
M
N
G
R
GSA
N
GG
Y
SDNYTHVQ
I
GAD
---
R
N
H
E
L
D
N
M
DLFTGV
L
L
TYTDSDA
SSHV
F
R
GKTKS
V
G
-----
G
G
L
YAS
A
LF
N
SG
--
AY
F
DLIGKY
L
H
D
DN
Q
Y
TADF
A
S
L
G
A
K
N
Y
S
SHSWYAGAE
V
GYRYHL
S
--
EE
AWV
EPQ
I
ELVYG
A
VSG
KS
F
K
W
EDR
GM
E
L
G
MK
DRDYN
PLIGR
S
GV
DM
GK
V
FSG
G
DW
K
I
TA
R
AG
LG
YQFDL
LTNGE
T
V
LRD
I
SGE
KR
F
N
G
E
KDSRML
VS
VGLNA
E
IK
N
N
M
R
F
GLE
L
D
KSAFGKYN
V
D
N
AINANIRY
Y
F
fig|340184.6.peg.4686
Escherichia coli B7A (313-1366/1366)
Q
N
D
F
D
K
TI
TYSAGAGA-
-
L
Q
W
K
YD
AV
N
G
T
G
S
L
T
QG
NTI
W
D
MHG
KKGN
----
DLN
A
GKNL
L
L
T
G
N
NG
E
V
V
L
Q
D
S
V
N
QGAG
Y
L
Q
F
AN
DY
K
V
SALNGQ
-
TW
M
G
G
G
V
I
T
D
K
G
TH
V
L
W
Q
VNGV
A
GDNLHK
L
G
E
GTL
M
V
N
GTG
V
N
A
GGLKVGDGTV
I
LNQQ
L
D
TD
G
KV
QAFS
S
V
D
I
S
SGRPTVVL
S
D
SR
QVNPD
N
---
I
S
WGYRGG
R
LDLNGN
N
LTF
T
R
I
Q
AAD
Y
GA
I
I
T
--
N
-
T
SEKK
S
T
V
T
LD
LQSLKASDI
N
VP
-
INTINF
-
-
--
LGGR
GT
P
G
D
LY
--L
--
VESTGQYY
ILK
ESS
Y
S
PFF
--
SDLNNPNI
W
QS
VG
KDRNK
A
IDTVKHQK
I
E
-
ASSQPY
MY
HG
Q
L
N
GNM
D
VN
-
-IPQLSGKDVLT
L
DGS
V
N
L
P
E
G
S
I
T
KK
S
G
T
L
IF
QGHP
I
IHA
G
--------------------------
T
T
T
S
A
-
------
--
-
----
-
-
-
-
-
S
Q
S
DWE
T
R
Q
F
TLGK
L
K
L
D
A
A
T
F
Y
L
S
RN
G
Q
M
HGD
I
N
A
V
N
G
S
T
V
I
LGS
DH
VF
T
D
K
NDG
T
G
------
NSVSSV
EG
T
A
T
A
TTTV
D
Q
S
D
Y
R
G
N
L
T
L
ENK
S
S
L
Q
I
-
REK
F
T
GGI
E
A
Y
D
-
S
S
V
S
V
N
S
Q
N
V
I
F
DRV
G
S
F
VN
-
SSL
S
L
E
KW
A
SLT
A
QS
G
I
F
S
T
G
V
V
DLKGNAS
L
T
L
TGI
P
SAEKHSYYSPVVSIIE-GIN
L
-
G
SQSS
L
TVENMGYLN
S
DI
MAENE
-
AM
-
VNL
G
-DSGAE-
----------
TGKTD---
S
PLFIS
L
M
-
KGYNAVLS
G
N
I
T
------
G
AK
S
I
V
N
M
N
N
S
L
--
W
C
I
T
G
N
S
TTGM
L
NARN
S
RVEVGN
--
-GKNFAN
L
Q
VKELVADN
S
T
F
L
M
H
T
N
NSQ
AD
H
L
N
V
T
D
K
L
S
G
S
R
N
T
I
L
V
N
F
LNNPANG--M
N
V
T
L
I
TAP
KG
S
NE
K
M
--
F
QAG
T
Q
QI
GFS
NV
TP
V
I
SAEKTD
-------------------------------------------------------------------------------
SS
TKW
V
L
T
GY
QTVS
D
VRTSKI
A
TD
FM
A
SG
Y
K
S
F
L
R
EVNNLN
K
RMGDLRD
T
Q
G
DT
G
V
W
G
RI
M
N
G
R
GSA
N
GG
Y
SDNYTHVQ
I
GAD
---
R
N
H
E
L
D
N
M
DLFTGV
L
L
TYTDSDA
SSHV
F
R
GKTKS
V
G
-----
G
G
L
YAS
A
LF
N
SG
--
AY
F
DLIGKY
L
H
D
DN
Q
Y
TADF
A
S
L
G
A
K
N
Y
S
SHSWYAGAE
V
GYRYHL
S
--
EE
AWV
EPQ
I
ELVYG
A
VSG
KS
F
K
W
EDR
GM
E
L
G
MK
DRDYN
PLIGR
S
GV
DM
GK
V
FSG
G
DW
K
I
TA
R
AG
LG
YQFDL
LTNGE
T
V
LRD
I
SGE
KR
F
N
G
E
KDSRML
VS
VGLNA
E
IK
N
N
M
R
F
GLE
L
D
KSAFGKYN
V
D
N
AINANIRY
Y
F
fig|331111.12.peg.299
Escherichia coli E24377A (310-1366/1366)
K
H
D
F
D
K
TI
SYDSKKGS-
-
L
Q
W
R
YD
KD
A
G
V
GTL
S
Q
E
GVV
W
D
MHG
KKGE
----
DLN
A
GKNL
Q
F
T
G
N
NG
E
V
I
L
H
D
S
I
D
QGAG
Y
L
Q
F
FN
N
YTV
TSLTDQ
-
TW
T
G
G
GII
T
E
K
G
VN
V
L
W
Q
VNGV
N
N
DNLHK
V
G
E
GTL
T
V
N
G
K
G
V
N
N
GGLKVGDGTV
I
LNQ
R
P
D
DN
G
HK
QAFS
S
I
N
I
S
SGR
A
TV
I
L
S
D
AN
QVNPD
K
---
I
S
WGYRGG
T
LDLNGN
N
V
TF
T
RL
Q
AAD
Y
GA
I
I
S
NN
N
-
N
NKNK
S
E
L
T
L
K
LQTLNENDI
SV
D
-
VKTYEV
-
-
--
FGGR
G
S
P
G
D
LY
--Y
--
VSASNTYF
ILK
SKA
YG
PFF
--
SDLDNTNV
W
QN
VG
HDRDK
A
IQIVKQQK
I
E
-
ESSQPY
M
FHG
Q
L
N
G
Y
M
D
VN
-
-IHPLSGKDVLT
L
DGS
V
N
L
P
E
G
V
I
T
KK
S
G
T
L
IF
QGHPVIHA
G
--------------------------
M
T
T
S
A
-
------
--
-
----
-
-
-
-
-
G
Q
S
DWENR
Q
F
TMDK
L
K
L
D
A
A
T
F
H
L
S
RN
T
R
M
QGD
I
S
A
A
N
G
S
T
V
I
LGS
SR
VF
T
D
K
NDG
T
G
------
NAVSSV
EG
S
S
T
A
TTAA
D
Q
S
Y
Y
S
G
N
V
L
L
ENH
S
S
L
E
V
-
REN
F
T
GGI
E
A
Y
D
-
S
S
V
S
V
T
S
Q
N
A
I
L
DHV
G
S
F
IN
-
SSL
L
L
E
K
GA
KLT
A
QS
G
I
F
T
N
N
T
M
EIKENAS
L
T
L
TGI
P
SVGKPGYYSPVISTTE-GIH
L
-
G
ERAS
L
SVKNMGYLS
S
N
I
IAEDS
A
AI
-
INL
G
-DSNAT-
----------
IGKTD---
S
PLFNT
L
M
-
RGYNAVLQ
G
N
I
M
------
G
PQ
S
S
V
N
M
N
N
A
L
--
W
H
S
D
R
N
S
EIKE
L
KAND
S
QIELGG
--
-RGHFAK
L
R
VKELIASN
S
V
F
LV
H
V
N
NGQ
AD
Q
L
N
V
T
G
K
L
Q
G
S
N
N
T
I
L
V
N
F
FNKAANG--T
N
V
T
L
I
TAP
KG
S
DE
N
T
--
F
KAG
T
Q
QI
GFS
NI
TP
E
I
RTENTD
-------------------------------------------------------------------------------
TA
TKW
V
L
T
GY
QSVA
D
ARASKI
A
TD
FM
D
SG
Y
K
S
F
L
TEVNNLN
K
RMGDLRD
S
Q
G
D
AG
G
WARI
M
N
G
T
GS
G
E
S
G
Y
R
DNYTHVQ
I
GAD
---
RKH
E
L
N
G
L
N
LFTG
AL
L
TYTDS
N
A
SSQA
FSGKTKS
L
G
-----
G
G
V
YAS
G
LF
E
SG
--
AY
F
DLIGKY
L
HHDN
R
Y
TLNF
A
S
L
G
E
R
S
Y
T
T
HS
L
YAGAE
I
GYRYH
M
S
--
EN
T
WV
EPQ
M
ELVYG
S
VSG
KS
F
N
W
KDQ
GM
Q
LSMK
DKDYH
PLIGRTGV
DV
G
R
V
FSG
DT
W
K
VTA
R
AG
LS
YQFDL
LANGE
T
V
L
Q
D
A
SG
K
KH
F
K
G
E
KDSRML
MN
VG
T
N
VE
VK
DN
M
R
F
GLE
L
EKSAFG
R
YN
I
D
N
S
INAN
F
RY
Y
F
fig|585395.4.peg.3978
Escherichia coli O103:H2 str. 12009 (267-1329/1329)
L
Q
D
D
L
K
P
I
I
V--ASPEEN
I
L
R
W
E
F
D
RS
R
G
T
GTL
S
QG
EKI
F
S
M
T
G
SVNG
----
N
A
N
T
G
N
NL
V
F
S
G
N
E
G
K
I
E
L
VS
S
V
E
QGAG
Y
L
Q
F
DK
DYTV
LTNNNS
-
TW
T
GAGIIV
G
D
E
AN
V
K
W
G
VNG
I
A
GDNLHK
V
G
S
GTL
T
V
N
G
H
G
E
N
K
GGLKVGDG
V
VVL
E
QQ
P
D
AN
Q
KQ
QAFS
H
I
N
IASGR
A
TV
K
L
N
G
AN
QV
D
A
D
N
---
I
S
WGYRGG
K
LDLNG
Y
D
F
TF
S
RL
Q
AAD
Y
GA
E
I
S
--
N
D
N
QTDK
S
I
V
T
L
S
LSPLKAEEI
N
V
V
-
VNNINI
-
-
--
MGGT
G
K
P
G
D
LY
YTT
--
FDG--NYY
L
LK
SNR
YG
SAL
F
G
A-LNNQSE
W
QR
L
G
KDKEK
A
IGLYTQMK
M
Q
E
SAPLSY
I
Y
HG
K
I
T
GN
T
S
VE
-
-IPKLAGNDILT
L
DGS
V
S
I
-
S
G
D
M
S
KQ
D
G
A
L
IF
QGHPVIHA
G
--------------------------
Q
T
V
S
A
-
------
--
-
----
-
-
-
-
-
S
Q
S
DWENR
E
F
SLNN
L
N
L
N
N
V
D
F
S
L
S
RNA
F
M
NGN
I
R
A
V
N
Q
S
T
V
I
I
G
G
DT
VF
T
D
K
NDG
T
G
------
NDVISV
EG
K
S
A
A
SGT-
-
-
S
S
Y
T
G
H
I
T
L
EQK
S
A
L
D
I
-
RDN
F
R
GG
V
T
S
E
D
-
S
H
I
N
V
SS
S
S
V
L
F
SDA
S
S
F
IN
-
SSL
N
I
H
K
G
G
ALT
A
QG
GL
F
TS
G
S
I
DIG-DAS
L
L
L
TGT
P
VNSDDAAFLPTINMADGGFK
L
M
S
DSSV
L
KARDQASVV
GDI
ISDKQ
-
AT
-
ISF
G
TESGKE-
----------
GILSEKAS
R
GLAVG
L
L
-
SGFNTAYR
G
A
I
H
------
A
PS
A
S
A
T
M
N
NT
W
--
W
Q
L
T
G
D
S
SLRS
L
KNTG
S
MTYFTG
SA
ANKAFHT
LT
VDELTTNG
T
A
Y
A
M
R
TD
LKN
AD
K
L
V
V
N
Q
K
L
S
G
K
DN
I
L
L
V
D
F
LNKPT-GEKL
D
I
E
LV
S
AP
GN
S
SK
DV
--
F
KGS
E
Q
EI
GFS
NV
TP
V
I
TAIDAG
-------------------------------------------------------------------------------
DK
T
T
W
N
L
T
GY
RMAE
N
PAATQS
A
SG
L
A
S
VG
Y
K
S
F
LS
EVNNLN
K
RMGDLRDI
N
GEAGAWARI
M
SG
T
GSA
G
GGFSDN
H
THVQVG
V
D
---
K
KH
E
L
D
G
L
DLFTG
F
T
V
T
H
TDS
S
A
SADA
F
K
GKTKS
V
G
-----
A
G
L
YAS
A
M
F
D
SG
--
AY
I
DLIGKY
V
HHDN
E
Y
TATF
AG
L
G
T
R
DY
S
T
HSWYAGAE
A
GYR
C
H
V
T
--
ED
T
W
IEPQAELVYG
A
VSG
KQ
F
A
W
KDQ
GM
H
LSMK
DRDYN
PLIGRTGV
DV
GK
S
FSGKDW
K
VTA
R
AG
LG
YQFDL
LANGE
T
V
LRD
A
SGE
KR
I
K
G
E
KDSRML
MS
VGLNA
E
IR
DN
V
R
F
GLE
F
EKSAFGKYN
V
D
N
A
V
NAN
F
RY
S
F
fig|656393.3.peg.73
Escherichia coli H299 (265-1329/1329)
D
F
D
P
I
I
SFNKNSKEH
-
M
S
W
T
YD
AA
K
G
V
G
R
I
Q
Q
D
DQQ
F
V
MHG
NLNG
----
N
LN
A
GKNL
Y
F
T
G
E
NG
I
I
D
LKD
N
V
N
QGAG
Y
L
Q
F
AD
DYTV
TTSNDS
-
S
W
S
G
G
GIIV
N
Y
G
TT
V
K
W
G
I
NGV
S
GD
D
LHK
V
G
D
GTL
I
I
N
GTG
K
N
E
GGLK
I
G
A
GTV
I
L
E
Q
K
A
-
KN
N
DS
T
AFS
S
I
N
I
S
G
G
NSR
V
K
L
S
G
DN
Q
I
I
PD
N
---
V
S
WG
F
RGG
Y
LD
I
NG
K
N
TE
F
S
RL
Q
A
V
D
Y
GA
A
I
I
--
N
-
S
STDK
S
L
L
T
L
N
LSPLKKDEI
A
V
S
-
VKALDM
N
A
IF
QGGH
GT
A
G
D
LY
KTT
--
FYGPTQYY
L
LK
KPK
F
G
SVL
M
G
S-LKNTSE
W
QF
A
G
TDLNQ
A
VDMAKNNK
L
T
S
SAQASY
LY
HG
K
L
L
GNM
D
IV
-
-IPELTGNDILT
L
DGS
V
S
I
-
S
G
D
M
S
KQ
D
G
A
L
IF
QGHPVIHA
G
--------------------------
Q
T
V
S
A
-
------
--
-
----
-
-
-
-
-
S
Q
S
DWENR
E
F
SLNN
L
N
L
N
N
A
D
F
S
L
S
RNA
F
M
NGN
I
R
A
V
N
Q
S
T
V
I
I
G
G
DT
VF
T
D
K
NDG
T
G
------
NDVISV
EG
K
S
A
A
AGT-
-
-
S
S
Y
T
G
H
I
T
L
EQK
S
A
L
D
I
-
RDN
F
R
GG
V
T
S
E
D
-
S
H
I
N
V
SS
S
S
V
L
F
SDA
S
S
F
IN
-
SSL
N
I
H
K
G
G
ALT
A
QG
GL
F
TS
G
S
I
DIG-DAS
L
L
L
TGT
P
VNSDDAAFLPTINMADGGFK
L
M
S
DSSV
L
KARDQASVV
GDI
ISDKQ
-
AT
-
ISF
G
TESGKE-
----------
GILSEKAS
R
GLAVG
L
L
-
SGFNTAYR
G
A
I
H
------
A
PS
A
S
A
TV
N
NT
W
--
W
Q
L
T
G
D
S
SLRS
L
KNTG
S
MTYFTG
SA
ANKAFHT
LT
VDELTTNG
T
A
Y
A
M
R
TD
LKN
AD
K
L
V
V
N
K
K
L
S
G
K
DN
I
L
L
V
D
F
LNKPS-GEKL
D
I
E
LV
S
AP
GN
S
SK
DV
--
F
KGS
E
Q
AI
GFS
NV
TP
V
I
TTRETD
-------------------------------------------------------------------------------
DK
IT
W
S
L
T
GY
NTVA
N
KEATRN
A
AA
L
F
S
VD
Y
K
A
F
L
N
EVNNLN
K
RMGDLRDI
N
GEAGAWARI
M
SG
T
GSA
S
GGFSDNYTHVQVG
V
D
---
K
KH
E
L
D
G
L
DLFTG
F
T
V
T
H
TDS
S
A
SADV
FSGKTKS
V
G
-----
A
G
L
YAS
A
M
F
D
SG
--
AY
I
DLIGKY
V
HHDN
E
Y
TATF
AG
L
G
T
R
DY
S
T
HSWYAGAE
A
GYRYH
V
T
--
ED
AW
IEPQAELVYG
S
VSG
KQ
F
A
W
KDQ
GM
H
LSMK
DKDYN
PLIGRTGV
DV
GK
S
FSGKDW
K
VTA
R
AG
LG
YQFDL
LANGE
T
V
LRD
A
SGE
KR
I
K
G
E
KDSRML
MS
VGLNA
E
IR
DN
V
R
F
GLE
F
EKSAFGKYN
V
D
N
A
V
NAN
F
RY
S
F
fig|405955.9.peg.4271
Escherichia coli APEC O1 (306-1377/1377)
E
D
N
D
A
PV
TFRTSEGGA
-
L
E
W
S
F
N
SS
TG
A
G
A
L
T
QG
TTT
Y
A
MHG
QQGN
----
DLN
A
GKNL
I
F
Q
G
Q
NG
Q
I
N
LKD
S
V
S
QGAG
S
L
T
F
RD
N
YTV
TTSNGS
-
TW
T
GAGI
V
VD
N
G
VS
V
N
W
Q
VNGV
K
GDNLHK
I
G
E
GTL
T
V
Q
GTG
I
N
E
GGLKVGDG
K
VVLNQQAD
NK
G
QV
QAFS
S
V
N
IASGRPTVVL
T
D
ER
QVNPD
T
---
V
S
WGYRGG
T
LD
V
NGN
S
LTFH
Q
L
K
AAD
Y
GA
V
L
A
--
N
-
N
VDKR
A
T
I
T
LD
YALR-----
----
ADKVAL
N
G
WS
ESGK
GT
A
G
N
LY
KYN
NP
YTNTTDYF
ILK
QST
YG
YFP
--
TDQSSNAT
W
EF
VG
HSQGD
A
QKLVADR-
-
-
-
FNTAGY
L
FHG
Q
L
K
GN
L
N
VD
N
RLPEGVTG-ALV
MDG
A
A
D
I
-
S
GT
F
TQE
N
G
R
L
TL
QGHPVIHA
Y
--------------------------
N
T
Q
S
V
A
DKLAAS
GD
H
SVLT
Q
P
T
S
F
S
Q
E
DWENR
S
F
TFDR
L
S
L
K
N
T
D
F
G
L
G
RNA
T
L
NTT
I
Q
A
D
N
-
S
S
V
T
LG
D
SR
VF
I
D
K
NDG
Q
G
------
TAFTLE
EG
T
S
V
A
TKDA
D
K
S
V
F
N
G
T
V
N
L
DNQ
S
V
L
N
I
-
NDI
F
N
GGI
Q
A
N
-
N
S
T
V
N
ISS
D
S
A
V
L
GN-
S
T
L
TS
-
TA
L
N
L
N
K
GA
NAL
A
SQ
SF
V
SDG
P
V
NIS-DAT
L
S
L
NSR
P
--DEVSHTLLPVYDYAGSWN
L
K
G
DDAR
L
NVGPYSMLS
G
N
I
NVQDK
-
GT
-
VTL
G
GEGELSP
DL
--------
TLQNQMLY
S
-----
L
F
-
NGYRNIWS
G
S
L
N
------
A
PD
A
T
VSM
T
D
T
Q
--
W
S
M
N
G
N
S
TAGN
M
KLNR
T
IVGFNG
--
GTSPFTT
LT
TDNLDAVQ
S
A
FVM
R
TD
LNK
AD
K
L
V
I
N
K
S
A
T
G
H
DN
S
I
W
V
N
F
LKKPSNKDTL
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
RAS
TR
VV
GFS
DV
TP
I
L
SVRKED
-------------------------------------------------------------------------------
GK
K
E
W
V
L
D
GY
QVAR
N
DGQGKA
A
AT
FM
H
IS
Y
N
NFITEVNNLN
K
RMGDLRDI
N
GEAG
T
W
V
R
L
L
N
GSGSA
D
GGF
T
D
H
YT
LL
Q
M
GAD
---
RKH
E
L
G
S
M
DLFTGV
M
A
TYTD
T
DA
SADL
Y
SGKTKS
W
G
-----
G
G
F
YAS
G
LF
R
SG
--
AY
F
D
V
I
A
KYIH
NE
N
K
Y
DLNF
AG
A
G
K
QN
F
R
SHS
L
YAGAE
V
GYRYHL
T
--
DT
TF
V
EPQAELV
W
G
R
LQ
G
QT
F
N
W
NDS
GM
D
V
SM
R
RNSVN
PL
V
GRTGV
VS
GKTFSGKDW
S
L
TA
R
AG
LH
Y
E
FDL
TDSAD
V
H
L
K
D
A
A
GE
HQ
I
N
G
R
KDSRML
YG
VGLNAR
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
AINANIRY
S
F
fig|656419.3.peg.1851
Escherichia coli M718 (306-1377/1377)
E
D
N
D
A
PV
TFRTSEGGA
-
L
E
W
S
F
N
SS
TG
A
G
A
L
T
QG
TTT
Y
A
MHG
QQGN
----
DLN
A
GKNL
I
F
Q
G
Q
NG
Q
I
N
LKD
S
V
S
QGAG
S
L
T
F
RD
N
YTV
TTSNGS
-
TW
T
GAGI
V
VD
N
G
VS
V
N
W
Q
VNGV
K
GDNLHK
I
G
E
GTL
T
V
Q
GTG
I
N
E
GGLKVGDG
K
VVLNQQAD
NK
G
QV
QAFS
S
V
N
IASGRPTVVL
T
D
ER
QVNPD
T
---
V
S
WGYRGG
T
LD
V
NGN
S
LTFH
Q
L
K
AAD
Y
GA
V
L
A
--
N
-
N
VDKR
A
T
I
T
LD
YALR-----
----
ADKVAL
N
G
WS
ESGK
GT
A
G
N
LY
KYN
NP
YTNTTDYF
ILK
QST
YG
YFP
--
TDQSSNAT
W
EF
VG
HSQGD
A
QKLVADR-
-
-
-
FNTAGY
L
FHG
Q
L
K
GN
L
N
VD
N
RLPEGVTG-ALV
MDG
A
A
D
I
-
S
GT
F
TQE
N
G
R
L
TL
QGHPVIHA
Y
--------------------------
N
T
Q
S
V
A
DKLAAS
GD
H
SVLT
Q
P
T
S
F
S
Q
E
DWENR
S
F
TFDR
L
S
L
K
N
T
D
F
G
L
G
RNA
T
L
NTT
I
Q
A
D
N
-
S
S
V
T
LG
D
SR
VF
I
D
K
NDG
Q
G
------
TAFTLE
EG
T
S
V
A
TKDA
D
K
S
V
F
N
G
T
V
N
L
DNQ
S
V
L
N
I
-
NDI
F
N
GGI
Q
A
N
-
N
S
T
V
N
ISS
D
S
A
V
L
GN-
S
T
L
TS
-
TA
L
N
L
N
K
GA
NAL
A
SQ
SF
V
SDG
P
V
NIS-DAT
L
S
L
NSR
P
--DEVSHTLLPVYDYAGSWN
L
K
G
DDAR
L
NVGPYSMLS
G
N
I
NVQDK
-
GT
-
VTL
G
GEGELSP
DL
--------
TLQNQMLY
S
-----
L
F
-
NGYRNIWS
G
S
L
N
------
A
PD
A
T
VSM
T
D
T
Q
--
W
S
M
N
G
N
S
TAGN
M
KLNR
T
IVGFNG
--
GTSPFTT
LT
TDNLDAVQ
S
A
FVM
R
TD
LNK
AD
K
L
V
I
N
K
S
A
T
G
H
DN
S
I
W
V
N
F
LKKPSNKDTL
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
RAS
TR
VV
GFS
DV
TP
I
L
SVRKED
-------------------------------------------------------------------------------
GK
K
E
W
V
L
D
GY
QVAR
N
DGQGKA
A
AT
FM
H
IS
Y
N
NFITEVNNLN
K
RMGDLRDI
N
GEAG
T
W
V
R
L
L
N
GSGSA
D
GGF
T
D
H
YT
LL
Q
M
GAD
---
RKH
E
L
G
S
M
DLFTGV
M
A
TYTD
T
DA
SADL
Y
SGKTKS
W
G
-----
G
G
F
YAS
G
LF
R
SG
--
AY
F
D
V
I
A
KYIH
NE
N
K
Y
DLNF
AG
A
G
K
QN
F
R
SHS
L
YAGAE
V
GYRYHL
T
--
DT
TF
V
EPQAELV
W
G
R
LQ
G
QT
F
N
W
NDS
GM
D
V
SM
R
RNSVN
PL
V
GRTGV
VS
GKTFSGKDW
S
L
TA
R
AG
LH
Y
E
FDL
TDSAD
V
H
L
K
D
A
A
GE
HQ
I
N
G
R
KDSRML
YG
VGLNAR
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
AINANIRY
S
F
fig|199310.1.peg.374
Escherichia coli CFT073 (305-1376/1376)
E
D
N
D
A
PV
FFNASSGAP
-
L
Q
W
K
F
D
SS
TG
T
G
S
L
K
QG
SDE
Y
A
MHG
QKGS
----
DLN
A
GKNL
T
F
L
G
H
NG
Q
I
D
L
E
N
S
V
T
QGAG
S
L
T
F
TD
DYTV
TTSNGS
-
TW
T
GAGIIVD
K
D
AS
V
N
W
Q
VNGV
K
GDNLHK
I
G
E
GTL
V
V
Q
GTG
V
N
E
GGLKVGDGTVVLNQQAD
SS
G
HV
QAFS
S
V
N
IASGRPTVVL
A
D
NQ
QVNPD
N
---
I
S
WGYRGG
V
LD
V
NGN
D
LTFH
K
L
N
AAD
Y
GA
T
L
G
--
N
-
S
SDKT
A
N
I
T
LD
YQTR-----
----
PADVKV
N
E
WS
SSNR
GT
V
G
S
LY
IYN
NP
YTHTVDYF
ILK
TSS
YG
WFP
--
TGQVSNEH
W
EY
VG
HDQNS
A
QALLANR-
-
-
-
INNKGY
LY
HG
K
L
L
GN
I
N
FS
N
KATPGTTG-ALV
MDGS
A
N
M
-
S
GT
F
TQE
N
G
R
L
TI
QGHPVIHA
S
--------------------------
T
S
Q
S
I
A
NTVSSL
GD
N
SVLT
Q
P
T
S
F
TQ
D
DWENR
T
F
SFGS
L
V
L
K
D
T
D
F
G
L
G
RNA
T
L
NTT
I
Q
A
D
N
-
S
S
V
T
LG
D
SR
VF
I
D
K
K
DG
Q
G
------
TAFTLE
EG
T
S
V
A
TKDA
D
K
S
V
F
N
G
T
V
N
L
DNQ
S
V
L
N
I
-
NEI
F
N
GGI
Q
A
N
-
N
S
T
V
N
ISS
D
S
A
V
L
EN-
S
T
L
TS
-
TA
L
N
L
N
K
GA
NVL
A
SQ
SF
V
SDG
P
V
NIS-DAT
L
S
L
NSR
P
--DEVSHTLLPVYDYAGSWN
L
K
G
DDAR
L
NVGPYSMLS
G
N
I
NVQDK
-
GT
-
VTL
G
GEGELSP
DL
--------
TLQNQMLY
S
-----
L
F
-
NGYRNTWS
G
S
L
N
------
A
PD
A
T
VSM
T
D
T
Q
--
W
S
M
N
G
N
S
TAGN
M
KLNR
T
IVGFNG
--
GTSSFTT
LT
TDNLDAVQ
S
A
FVM
R
TD
LNK
AD
K
L
V
I
N
K
S
A
T
G
H
DN
S
I
W
V
N
F
LKKPSDKDTL
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
RAS
TR
VV
GFS
DV
TP
T
L
SVRKED
-------------------------------------------------------------------------------
GK
K
E
W
V
L
D
GY
QVAR
N
DGQGKA
A
AT
FM
H
IS
Y
N
NFITEVNNLN
K
RMGDLRDI
N
GEAG
T
W
V
R
L
L
N
GSGSA
D
GGF
T
D
H
YT
LL
Q
M
GAD
---
RKH
E
L
G
S
M
DLFTGV
M
A
TYTD
T
DA
SAGL
Y
SGKTKS
W
G
-----
G
G
F
YAS
G
LF
R
SG
--
AY
F
DLI
A
KYIH
NE
N
K
Y
DLNF
AG
A
G
K
QN
F
R
SHS
L
YAGAE
V
GYRYHL
T
--
DT
TF
V
EPQAELV
W
G
R
LQ
G
QT
F
N
W
NDS
GM
D
V
SM
R
RNSVN
PL
V
GRTGV
VS
GKTFSGKDW
S
L
TA
R
AG
LH
Y
E
FDL
TDSAD
V
H
L
K
D
A
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VGLNAR
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
AINANIRY
S
F
fig|749528.3.peg.1421
Escherichia coli MS 45-1 (305-1376/1376)
E
D
N
D
A
PV
FFNASSGAP
-
L
Q
W
K
F
D
SS
TG
T
G
S
L
K
QG
SDE
Y
A
MHG
QKGS
----
DLN
A
GKNL
T
F
L
G
H
NG
Q
I
D
L
E
N
S
V
T
QGAG
S
L
T
F
TD
DYTV
TTSNGS
-
TW
T
GAGIIVD
K
D
AS
V
N
W
Q
VNGV
K
GDNLHK
I
G
E
GTL
V
V
Q
GTG
V
N
E
GGLKVGDGTVVLNQQAD
SS
G
HV
QAFS
S
V
N
IASGRPTVVL
A
D
NQ
QVNPD
N
---
I
S
WGYRGG
V
LD
V
NGN
D
LTFH
K
L
N
AAD
Y
GA
T
L
G
--
N
-
S
SDKT
A
N
I
T
LD
YQTR-----
----
PADVKV
N
E
WS
SSNR
GT
V
G
S
LY
IYN
NP
YTHTVDYF
ILK
TSS
YG
WFP
--
TGQVSNEH
W
EY
VG
HDQNS
A
QALLANR-
-
-
-
INNKGY
LY
HG
K
L
L
GN
I
N
FS
N
KATPGTTG-ALV
MDGS
A
N
M
-
S
GT
F
TQE
N
G
R
L
TI
QGHPVIHA
S
--------------------------
T
S
Q
S
I
A
NTVSSL
GD
N
SVLT
Q
P
T
S
F
TQ
D
DWENR
T
F
SFGS
L
V
L
K
D
T
D
F
G
L
G
RNA
T
L
NTT
I
Q
A
D
N
-
S
S
V
T
LG
D
SR
VF
I
D
K
K
DG
Q
G
------
TAFTLE
EG
T
S
V
A
TKDA
D
K
S
V
F
N
G
T
V
N
L
DNQ
S
V
L
N
I
-
NEI
F
N
GGI
Q
A
N
-
N
S
T
V
N
ISS
D
S
A
V
L
EN-
S
T
L
TS
-
TA
L
N
L
N
K
GA
NVL
A
SQ
SF
V
SDG
P
V
NIS-DAT
L
S
L
NSR
P
--DEVSHTLLPVYDYAGSWN
L
K
G
DDAR
L
NVGPYSMLS
G
N
I
NVQDK
-
GT
-
VTL
G
GEGELSP
DL
--------
TLQNQMLY
S
-----
L
F
-
NGYRNTWS
G
S
L
N
------
A
PD
A
T
VSM
T
D
T
Q
--
W
S
M
N
G
N
S
TAGN
M
KLNR
T
IVGFNG
--
GTSSFTT
LT
TDNLDAVQ
S
A
FVM
R
TD
LNK
AD
K
L
V
I
N
K
S
A
T
G
H
DN
S
I
W
V
N
F
LKKPSDKDTL
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
RAS
TR
VV
GFS
DV
TP
T
L
SVRKED
-------------------------------------------------------------------------------
GK
K
E
W
V
L
D
GY
QVAR
N
DGQGKA
A
AT
FM
H
IS
Y
N
NFITEVNNLN
K
RMGDLRDI
N
GEAG
T
W
V
R
L
L
N
GSGSA
D
GGF
T
D
H
YT
LL
Q
M
GAD
---
RKH
E
L
G
S
M
DLFTGV
M
A
TYTD
T
DA
SAGL
Y
SGKTKS
W
G
-----
G
G
F
YAS
G
LF
R
SG
--
AY
F
DLI
A
KYIH
NE
N
K
Y
DLNF
AG
A
G
K
QN
F
R
SHS
L
YAGAE
V
GYRYHL
T
--
DT
TF
V
EPQAELV
W
G
R
LQ
G
QT
F
N
W
NDS
GM
D
V
SM
R
RNSVN
PL
V
GRTGV
VS
GKTFSGKDW
S
L
TA
R
AG
LH
Y
E
FDL
TDSAD
V
H
L
K
D
A
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VGLNAR
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
AINANIRY
S
F
fig|753642.3.peg.1353
Escherichia coli NC101 (305-1376/1376)
E
D
N
D
A
PV
FFNASSGAP
-
L
Q
W
K
F
D
SS
TG
T
G
S
L
K
QG
SDE
Y
A
MHG
QKGS
----
DLN
A
GKNL
T
F
L
G
H
NG
Q
I
D
L
E
N
S
V
T
QGAG
S
L
T
F
TD
DYTV
TTSNGS
-
TW
T
GAGIIVD
K
D
AS
V
N
W
Q
VNGV
K
GDNLHK
I
G
E
GTL
V
V
Q
GTG
V
N
E
GGLKVGDGTVVLNQQAD
SS
G
HV
QAFS
S
V
N
IASGRPTVVL
A
D
NQ
QVNPD
N
---
I
S
WGYRGG
V
LD
V
NGN
D
LTFH
K
L
N
AAD
Y
GA
T
L
G
--
N
-
S
SDKT
A
N
I
T
LD
YQTR-----
----
PADVKV
N
E
WS
SSNR
GT
V
G
S
LY
IYN
NP
YTHTVDYF
ILK
TSS
YG
WFP
--
TGQVSNEH
W
EY
VG
HDQNS
A
QALLANR-
-
-
-
INNKGY
LY
HG
K
L
L
GN
I
N
FS
N
KATPGTTG-ALV
MDGS
A
N
M
-
S
GT
F
TQE
N
G
R
L
TI
QGHPVIHA
S
--------------------------
T
S
Q
S
I
A
NTVSSL
GD
N
SVLT
Q
P
T
S
F
TQ
D
DWENR
T
F
SFGS
L
V
L
K
D
T
D
F
G
L
G
RNA
T
L
NTT
I
Q
A
D
N
-
S
S
V
T
LG
D
SR
VF
I
D
K
K
DG
Q
G
------
TAFTLE
EG
T
S
V
A
TKDA
D
K
S
V
F
N
G
T
V
N
L
DNQ
S
V
L
N
I
-
NEI
F
N
GGI
Q
A
N
-
N
S
T
V
N
ISS
D
S
A
V
L
EN-
S
T
L
TS
-
TA
L
N
L
N
K
GA
NVL
A
SQ
SF
V
SDG
P
V
NIS-DAT
L
S
L
NSR
P
--DEVSHTLLPVYDYAGSWN
L
K
G
DDAR
L
NVGPYSMLS
G
N
I
NVQDK
-
GT
-
VTL
G
GEGELSP
DL
--------
TLQNQMLY
S
-----
L
F
-
NGYRNTWS
G
S
L
N
------
A
PD
A
T
VSM
T
D
T
Q
--
W
S
M
N
G
N
S
TAGN
M
KLNR
T
IVGFNG
--
GTSSFTT
LT
TDNLDAVQ
S
A
FVM
R
TD
LNK
AD
K
L
V
I
N
K
S
A
T
G
H
DN
S
I
W
V
N
F
LKKPSDKDTL
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
RAS
TR
VV
GFS
DV
TP
T
L
SVRKED
-------------------------------------------------------------------------------
GK
K
E
W
V
L
D
GY
QVAR
N
DGQGKA
A
AT
FM
H
IS
Y
N
NFITEVNNLN
K
RMGDLRDI
N
GEAG
T
W
V
R
L
L
N
GSGSA
D
GGF
T
D
H
YT
LL
Q
M
GAD
---
RKH
E
L
G
S
M
DLFTGV
M
A
TYTD
T
DA
SAGL
Y
SGKTKS
W
G
-----
G
G
F
YAS
G
LF
R
SG
--
AY
F
DLI
A
KYIH
NE
N
K
Y
DLNF
AG
A
G
K
QN
F
R
SHS
L
YAGAE
V
GYRYHL
T
--
DT
TF
V
EPQAELV
W
G
R
LQ
G
QT
F
N
W
NDS
GM
D
V
SM
R
RNSVN
PL
V
GRTGV
VS
GKTFSGKDW
S
L
TA
R
AG
LH
Y
E
FDL
TDSAD
V
H
L
K
D
A
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VGLNAR
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
AINANIRY
S
F
fig|869729.3.peg.3412
Escherichia coli UM146 (305-1376/1376)
E
D
N
D
A
PV
FFNASSGAP
-
L
Q
W
K
F
D
SS
TG
T
G
S
L
K
QG
SDE
Y
A
MHG
QKGS
----
DLN
A
GKNL
T
F
L
G
H
NG
Q
I
D
L
E
N
S
V
T
QGAG
S
L
T
F
TD
DYTV
TTSNGS
-
TW
T
GAGIIVD
K
D
AS
V
N
W
Q
VNGV
K
GDNLHK
I
G
E
GTL
V
V
Q
GTG
V
N
E
GGLKVGDGTVVLNQQAD
SS
G
HV
QAFS
S
V
N
IASGRPTVVL
A
D
NQ
QVNPD
N
---
I
S
WGYRGG
V
LD
V
NGN
D
LTFH
K
L
N
AAD
Y
GA
T
L
G
--
N
-
S
SDKT
A
N
I
T
LD
YQTR-----
----
PADVKV
N
E
WS
SSNR
GT
V
G
S
LY
IYN
NP
YTHTVDYF
ILK
TSS
YG
WFP
--
TGQVSNEH
W
EY
VG
HDQNS
A
QALLANR-
-
-
-
INNKGY
LY
HG
K
L
L
GN
I
N
FS
N
KATPGTTG-ALV
MDGS
A
N
M
-
S
GT
F
TQE
N
G
R
L
TI
QGHPVIHA
S
--------------------------
T
S
Q
S
I
A
NTVSSL
GD
N
SVLT
Q
P
T
S
F
TQ
D
DWENR
T
F
SFGS
L
V
L
K
D
T
D
F
G
L
G
RNA
T
L
NTT
I
Q
A
D
N
-
S
S
V
T
LG
D
SR
VF
I
D
K
K
DG
Q
G
------
TAFTLE
EG
T
S
V
A
TKDA
D
K
S
V
F
N
G
T
V
N
L
DNQ
S
V
L
N
I
-
NEI
F
N
GGI
Q
A
N
-
N
S
T
V
N
ISS
D
S
A
V
L
EN-
S
T
L
TS
-
TA
L
N
L
N
K
GA
NVL
A
SQ
SF
V
SDG
P
V
NIS-DAT
L
S
L
NSR
P
--DEVSHTLLPVYDYAGSWN
L
K
G
DDAR
L
NVGPYSMLS
G
N
I
NVQDK
-
GT
-
VTL
G
GEGELSP
DL
--------
TLQNQMLY
S
-----
L
F
-
NGYRNTWS
G
S
L
N
------
A
PD
A
T
VSM
T
D
T
Q
--
W
S
M
N
G
N
S
TAGN
M
KLNR
T
IVGFNG
--
GTSSFTT
LT
TDNLDAVQ
S
A
FVM
R
TD
LNK
AD
K
L
V
I
N
K
S
A
T
G
H
DN
S
I
W
V
N
F
LKKPSDKDTL
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
RAS
TR
VV
GFS
DV
TP
T
L
SVRKED
-------------------------------------------------------------------------------
GK
K
E
W
V
L
D
GY
QVAR
N
DGQGKA
A
AT
FM
H
IS
Y
N
NFITEVNNLN
K
RMGDLRDI
N
GEAG
T
W
V
R
L
L
N
GSGSA
D
GGF
T
D
H
YT
LL
Q
M
GAD
---
RKH
E
L
G
S
M
DLFTGV
M
A
TYTD
T
DA
SAGL
Y
SGKTKS
W
G
-----
G
G
F
YAS
G
LF
R
SG
--
AY
F
DLI
A
KYIH
NE
N
K
Y
DLNF
AG
A
G
K
QN
F
R
SHS
L
YAGAE
V
GYRYHL
T
--
DT
TF
V
EPQAELV
W
G
R
LQ
G
QT
F
N
W
NDS
GM
D
V
SM
R
RNSVN
PL
V
GRTGV
VS
GKTFSGKDW
S
L
TA
R
AG
LH
Y
E
FDL
TDSAD
V
H
L
K
D
A
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VGLNAR
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
AINANIRY
S
F
fig|405955.9.peg.235
Escherichia coli APEC O1 (305-1376/1376)
E
D
N
D
A
PV
FFNASSGAP
-
L
Q
W
K
F
D
SS
TG
T
G
S
L
K
QG
SDE
Y
A
MHG
QKGS
----
DLN
A
GKNL
T
F
L
G
H
NG
Q
I
D
L
E
N
S
V
T
QGAG
S
L
T
F
TD
DYTV
TTSNGS
-
TW
T
GAGIIVD
K
D
AS
V
N
W
Q
VNGV
K
GDNLHK
I
G
E
GTL
V
V
Q
GTG
V
N
E
GGLKVGDGTVVLNQQAD
SS
G
HV
QAFS
S
V
N
IASGRPTVVL
A
D
NQ
QVNPD
N
---
I
S
WGYRGG
V
LD
V
NGN
D
LTFH
K
L
N
AAD
Y
GA
T
L
G
--
N
-
S
SDKT
A
N
I
T
LD
YQTR-----
----
PANVKV
N
E
WS
SSNR
GT
V
G
S
LY
IYN
NP
YTHTVDYF
ILK
TSS
YG
WFP
--
TGQVSNEH
W
EY
VG
HDQNS
A
QALLANR-
-
-
-
INNKGY
LY
HG
K
L
L
GN
I
N
FS
N
KATPGTTG-ALV
MDGS
A
N
M
-
S
GT
F
TQE
N
G
R
L
TI
QGHPVIHA
S
--------------------------
T
S
Q
S
I
A
NTVSSL
GD
N
SVLT
Q
P
T
S
F
TQ
D
DWENR
T
F
SFGS
L
V
L
K
D
T
D
F
G
L
G
RNA
T
L
NTT
I
Q
A
D
N
-
S
S
V
T
LG
D
SR
VF
I
D
K
K
DG
Q
G
------
TAFTLE
EG
T
S
V
A
TKDA
D
K
S
V
F
N
G
T
V
N
L
DNQ
S
V
L
N
I
-
NEI
F
N
GGI
Q
A
N
-
N
S
T
V
N
ISS
D
S
A
V
L
EN-
S
T
L
TS
-
TA
L
N
L
N
K
GA
NVL
A
SQ
SF
V
SDG
P
V
NIS-DAT
L
S
L
NSR
P
--DEVSHTLLPVYDYAGSWN
L
K
G
DDAR
L
NVGPYSMLS
G
N
I
NVQDK
-
GT
-
VTL
G
GEGELSP
DL
--------
TLQNQMLY
S
-----
L
F
-
NGYRNTWS
G
S
L
N
------
A
PD
A
T
VSM
T
D
T
Q
--
W
S
M
N
G
N
S
TAGN
M
KLNR
T
IVGFNG
--
GTSSFTT
LT
TDNLDAVQ
S
A
FVM
R
TD
LNK
AD
K
L
V
I
N
K
S
A
T
G
H
DN
S
I
W
V
N
F
LKKPSDKDTL
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
RAS
TR
VV
GFS
DV
TP
T
L
SVRKED
-------------------------------------------------------------------------------
GK
K
E
W
V
L
D
GY
QVAR
N
DGQGKA
A
AT
FM
H
IS
Y
N
NFITEVNNLN
K
RMGDLRDI
N
GEAG
T
W
V
R
L
L
N
GSGSA
D
GGF
T
D
H
YT
LL
Q
M
GAD
---
RKH
E
L
G
S
M
DLFTGV
M
A
TYTD
T
DA
SAGL
Y
SGKTKS
W
G
-----
G
G
F
YAS
G
LF
R
SG
--
AY
F
DLI
A
KYIH
NE
N
K
Y
DLNF
AG
A
G
K
QN
F
R
SHS
L
YAGAE
V
GYRYHL
T
--
DT
TF
V
EPQAELV
W
G
R
LQ
G
QT
F
N
W
NDS
GM
D
V
SM
R
RNSVN
PL
V
GRTGV
VS
GKTFSGKDW
S
L
TA
R
AG
LH
Y
E
FDL
TDSAD
V
H
L
K
D
A
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VGLNAR
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
AINANIRY
S
F
fig|405955.13.peg.5093
Escherichia coli APEC O1 (234-1305/1305)
E
D
N
D
A
PV
TFRTSEGGA
-
L
E
W
S
F
N
SS
TG
A
G
A
L
T
QG
TTT
Y
A
MHG
QQGN
----
DLN
A
GKNL
I
F
Q
G
Q
NG
Q
I
N
LKD
S
V
S
QGAG
S
L
T
F
RD
N
YTV
TTSNGS
-
TW
T
GAGI
V
VD
N
G
VS
V
N
W
Q
VNGV
K
GDNLHK
I
G
E
GTL
T
V
Q
GTG
I
N
E
GGLKVGDG
K
VVLNQQAD
NK
G
QV
QAFS
S
V
N
IASGRPTVVL
T
D
ER
QVNPD
T
---
V
S
WGYRGG
T
LD
V
NGN
S
LTFH
Q
L
K
AAD
Y
GA
V
L
A
--
N
-
N
VDKR
A
T
I
T
LD
YALR-----
----
ADKVAL
N
G
WS
ESGK
GT
A
G
N
LY
KYN
NP
YTNTTDYF
ILK
QST
YG
YFP
--
TDQSSNAT
W
EF
VG
HSQGD
A
QKLVADR-
-
-
-
FNTAGY
L
FHG
Q
L
K
GN
L
N
VD
N
RLPEGVTG-ALV
MDG
A
A
D
I
-
S
GT
F
TQE
N
G
R
L
TL
QGHPVIHA
Y
--------------------------
N
T
Q
S
V
A
DKLAAS
GD
H
SVLT
Q
P
T
S
F
S
Q
E
DWENR
S
F
TFDR
L
S
L
K
N
T
D
F
G
L
G
RNA
T
L
NTT
I
Q
A
D
N
-
S
S
V
T
LG
D
SR
VF
I
D
K
NDG
Q
G
------
TAFTLE
EG
T
S
V
A
TKDA
D
K
S
V
F
N
G
T
V
N
L
DNQ
S
V
L
N
I
-
NDI
F
N
GGI
Q
A
N
-
N
S
T
V
N
ISS
D
S
A
V
L
GN-
S
T
L
TS
-
TA
L
N
L
N
K
GA
NAL
A
SQ
SF
V
SDG
P
V
NIS-DAT
L
S
L
NSR
P
--DEVSHTLLPVYDYAGSWN
L
K
G
DDAR
L
NVGPYSMLS
G
N
I
NVQDK
-
GT
-
VTL
G
GEGELSP
DL
--------
TLQNQMLY
S
-----
L
F
-
NGYRNIWS
G
S
L
N
------
A
PD
A
T
VSM
T
D
T
Q
--
W
S
M
N
G
N
S
TAGN
M
KLNR
T
IVGFNG
--
GTSPFTT
LT
TDNLDAVQ
S
A
FVM
R
TD
LNK
AD
K
L
V
I
N
K
S
A
T
G
H
DN
S
I
W
V
N
F
LKKPSNKDTL
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
RAS
TR
VV
GFS
DV
TP
I
L
SVRKED
-------------------------------------------------------------------------------
GK
K
E
W
V
L
D
GY
QVAR
N
DGQGKA
A
AT
FM
H
IS
Y
N
NFITEVNNLN
K
RMGDLRDI
N
GEAG
T
W
V
R
L
L
N
GSGSA
D
GGF
T
D
H
YT
LL
Q
M
GAD
---
RKH
E
L
G
S
M
DLFTGV
M
A
TYTD
T
DA
SADL
Y
SGKTKS
W
G
-----
G
G
F
YAS
G
LF
R
SG
--
AY
F
D
V
I
A
KYIH
NE
N
K
Y
DLNF
AG
A
G
K
QN
F
R
SHS
L
YAGAE
V
GYRYHL
T
--
DT
TF
V
EPQAELV
W
G
R
LQ
G
QT
F
N
W
NDS
GM
D
V
SM
R
RNSVN
PL
V
GRTGV
VS
GKTFSGKDW
S
L
TA
R
AG
LH
Y
E
FDL
TDSAD
V
H
L
K
D
A
A
GE
HQ
I
N
G
R
KDSRML
YG
VGLNAR
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
AINANIRY
S
F
fig|340197.3.peg.1397
Escherichia coli F11 (305-1376/1376)
E
D
N
D
A
PV
FFNASSGAP
-
L
Q
W
K
F
D
SS
TG
T
G
S
L
K
QG
SDE
Y
A
MHG
QKGS
----
DLN
A
GKNL
T
F
L
G
H
NG
Q
I
D
L
E
N
S
V
T
QGAG
S
L
T
F
TD
DYTV
TTSNGS
-
TW
T
GAGIIVD
K
D
AS
V
N
W
Q
VNGV
K
GDNLHK
I
G
E
GTL
V
V
Q
GTG
V
N
E
GGLKVGDGTVVLNQQAD
SS
G
HV
QAFS
S
V
N
IASGRPTVVL
A
D
NQ
QVNPD
N
---
I
S
WGYRGG
V
LD
V
NGN
D
LTFH
K
L
N
AAD
Y
GA
T
L
G
--
N
-
S
SDKT
A
N
I
T
LD
YQTH-----
----
PADVKV
N
E
WS
SSNR
GT
V
G
S
LY
IYN
NP
YTHTVDYF
ILK
TSS
YG
WFP
--
TGQVSNEH
W
EY
VG
HDQNS
A
QALLANR-
-
-
-
INNKGY
LY
HG
K
L
L
GN
I
N
FS
N
KATPGTTG-ALV
MDGS
A
N
M
-
S
GT
F
TQE
N
G
R
L
TI
QGHPVIHA
S
--------------------------
T
S
Q
S
I
A
NTVSSL
GD
N
SVLT
Q
P
T
S
F
TQ
D
DWENR
T
F
SFGS
L
V
L
K
D
T
D
F
G
L
G
RNA
T
L
NTT
I
Q
A
D
N
-
S
S
V
T
LG
D
SR
VF
I
D
K
K
DG
Q
G
------
TAFTLE
EG
T
S
V
A
TKDA
D
K
S
V
F
N
G
T
V
N
L
DNQ
S
V
L
N
I
-
NDI
F
N
GGI
Q
A
N
-
N
S
T
V
N
ISS
D
S
A
I
L
GN-
S
T
L
TS
-
TA
L
N
L
N
K
GA
NAL
A
SQ
SF
V
SDG
P
V
NIS-DAT
L
S
L
NSR
P
--DEVSHTLLPVYDYAGSWN
L
K
G
DDAR
L
NVGPYSMLS
G
N
I
NVQDK
-
GT
-
VTL
G
GEGELSP
DL
--------
TLQNQMLY
S
-----
L
F
-
NGYRNTWS
G
S
L
N
------
A
PD
A
T
VSM
T
D
T
Q
--
W
S
M
N
G
N
S
TAGN
M
KLNR
T
IVGFNG
--
GTSSFTT
LT
TDNLDAVQ
S
A
FVM
R
TD
LNK
AD
K
L
V
I
N
K
S
A
T
G
H
DN
S
I
W
V
N
F
LKKPSDKDTL
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
RAS
TR
VV
GFS
DV
TP
T
L
SVRKED
-------------------------------------------------------------------------------
GK
K
E
W
V
L
D
GY
QVAR
N
DGQGKA
A
AT
FM
H
IS
Y
N
NFITEVNNLN
K
RMGDLRDI
N
GEAG
T
W
V
R
L
L
N
GSGSA
D
GGF
T
D
H
YT
LL
Q
M
GAD
---
RKH
E
L
G
S
M
DLFTGV
M
A
TYTD
T
DA
SAGL
Y
SGKTKS
W
G
-----
G
G
F
YAS
G
LF
R
SG
--
AY
F
DLI
A
KYIH
NE
N
K
Y
DLNF
AG
A
G
K
QN
F
R
SHS
L
YAGAE
V
GYRYHL
T
--
DT
TF
V
EPQAELV
W
G
R
LQ
G
QT
F
N
W
NDS
GM
D
V
SM
R
RNSVN
PL
V
GRTGV
VS
GKTFSGKDW
S
L
TA
R
AG
LH
Y
E
FDL
TDSAD
V
H
L
K
D
A
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VGLNAR
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
AINANIRY
S
F
fig|656440.3.peg.153
Escherichia coli TA206 (305-1376/1376)
E
D
N
D
A
PV
FFNASSGAP
-
L
Q
W
K
F
D
SS
TG
T
G
S
L
K
QG
SDE
Y
A
MHG
QKGS
----
DLN
A
GKNL
T
F
L
G
H
NG
Q
I
D
L
E
N
S
V
T
QGAG
S
L
T
F
TD
DYTV
TTSNGS
-
TW
T
GAGIIVD
K
D
AS
V
N
W
Q
VNGV
K
GDNLHK
I
G
E
GTL
V
V
Q
GTG
V
N
E
GGLKVGDGTVVLNQQAD
SS
G
HV
QAFS
S
V
N
IASGRPTVVL
A
D
NQ
QVNPD
N
---
I
S
WGYRGG
V
LD
V
NGN
D
LTFH
K
L
N
AAD
Y
GA
T
L
G
--
N
-
S
SDKT
A
N
I
T
LD
YQTH-----
----
PADVKV
N
E
WS
SSNR
GT
V
G
S
LY
IYN
NP
YTHTVDYF
ILK
TSS
YG
WFP
--
TGQVSNEH
W
EY
VG
HDQNS
A
QALLANR-
-
-
-
INNKGY
LY
HG
K
L
L
GN
I
N
FS
N
KATPGTTG-ALV
MDGS
A
N
M
-
S
GT
F
TQE
N
G
R
L
TI
QGHPVIHA
S
--------------------------
T
S
Q
S
I
A
NTVSSL
GD
N
SVLT
Q
P
T
S
F
TQ
D
DWENR
T
F
SFGS
L
V
L
K
D
T
D
F
G
L
G
RNA
T
L
NTT
I
Q
A
D
N
-
S
S
V
T
LG
D
SR
VF
I
D
K
K
DG
Q
G
------
TAFTLE
EG
T
S
V
A
TKDA
D
K
S
V
F
N
G
T
V
N
L
DNQ
S
V
L
N
I
-
NDI
F
N
GGI
Q
A
N
-
N
S
T
V
N
ISS
D
S
A
I
L
GN-
S
T
L
TS
-
TA
L
N
L
N
K
GA
NAL
A
SQ
SF
V
SDG
P
V
NIS-DAT
L
S
L
NSR
P
--DEVSHTLLPVYDYAGSWN
L
K
G
DDAR
L
NVGPYSMLS
G
N
I
NVQDK
-
GT
-
VTL
G
GEGELSP
DL
--------
TLQNQMLY
S
-----
L
F
-
NGYRNTWS
G
S
L
N
------
A
PD
A
T
VSM
T
D
T
Q
--
W
S
M
N
G
N
S
TAGN
M
KLNR
T
IVGFNG
--
GTSSFTT
LT
TDNLDAVQ
S
A
FVM
R
TD
LNK
AD
K
L
V
I
N
K
S
A
T
G
H
DN
S
I
W
V
N
F
LKKPSDKDTL
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
RAS
TR
VV
GFS
DV
TP
T
L
SVRKED
-------------------------------------------------------------------------------
GK
K
E
W
V
L
D
GY
QVAR
N
DGQGKA
A
AT
FM
H
IS
Y
N
NFITEVNNLN
K
RMGDLRDI
N
GEAG
T
W
V
R
L
L
N
GSGSA
D
GGF
T
D
H
YT
LL
Q
M
GAD
---
RKH
E
L
G
S
M
DLFTGV
M
A
TYTD
T
DA
SAGL
Y
SGKTKS
W
G
-----
G
G
F
YAS
G
LF
R
SG
--
AY
F
DLI
A
KYIH
NE
N
K
Y
DLNF
AG
A
G
K
QN
F
R
SHS
L
YAGAE
V
GYRYHL
T
--
DT
TF
V
EPQAELV
W
G
R
LQ
G
QT
F
N
W
NDS
GM
D
V
SM
R
RNSVN
PL
V
GRTGV
VS
GKTFSGKDW
S
L
TA
R
AG
LH
Y
E
FDL
TDSAD
V
H
L
K
D
A
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VGLNAR
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
AINANIRY
S
F
fig|655817.3.peg.394
Escherichia coli ABU 83972 (17-1088/1088)
E
D
N
D
A
PV
FFNASSGAP
-
L
Q
W
K
F
D
SS
TG
T
G
S
L
K
QG
SDE
Y
A
MHG
QKGS
----
DLN
A
GKNL
T
F
L
G
H
NG
Q
I
D
L
E
N
S
V
T
QGAG
S
L
T
F
TD
DYTV
TTSNGS
-
TW
T
GAGIIVD
K
D
AS
V
N
W
Q
VNGV
K
GDNLHK
I
G
E
GTL
V
V
Q
GTG
V
N
E
GGLKVGDGTVVLNQQAD
SS
G
HV
QAFS
S
V
N
IASGRPTVVL
A
D
NQ
QVNPD
N
---
I
S
WGYRGG
V
LD
V
NGN
D
LTFH
K
L
N
AAD
Y
GA
T
L
G
--
N
-
S
SDKT
A
N
I
T
LD
YQTR-----
----
PADVKV
N
E
WS
SSNR
GT
V
G
S
LY
IYN
NP
YTHTVDYF
ILK
TSS
YG
WFP
--
TGQVSNEH
W
EY
VG
HDQNS
A
QALLANR-
-
-
-
INNKGY
LY
HG
K
L
L
GN
I
N
FS
N
KATPGTTG-ALV
MDGS
A
N
M
-
S
GT
F
TQE
N
G
R
L
TI
QGHPVIHA
S
--------------------------
T
S
Q
S
I
A
NTVSSL
GD
N
SVLT
Q
P
T
S
F
TQ
D
DWENR
T
F
SFGS
L
V
L
K
D
T
D
F
G
L
G
RNA
T
L
NTT
I
Q
A
D
N
-
S
S
V
T
LG
D
SR
VF
I
D
K
K
DG
Q
G
------
TAFTLE
EG
T
S
V
A
TKDA
D
K
S
V
F
N
G
T
V
N
L
DNQ
S
V
L
N
I
-
NEI
F
N
GGI
Q
A
N
-
N
S
T
V
N
ISS
D
S
A
V
L
EN-
S
T
L
TS
-
TA
L
N
L
N
K
GA
NVL
A
SQ
SF
V
SDG
P
V
NIS-DAT
L
S
L
NSR
P
--DEVSHTLLPVYDYAGSWN
L
K
G
DDAR
L
NVGPYSMLS
G
N
I
NVQDK
-
GT
-
VTL
G
GEGELSP
DL
--------
TLQNQMLY
S
-----
L
F
-
NGYRNTWS
G
S
L
N
------
A
PD
A
T
VSM
T
D
T
Q
--
W
S
M
N
G
N
S
TAGN
M
KLNR
T
IVGFNG
--
GTSSFTT
LT
TDNLDAVQ
S
A
FVM
R
TD
LNK
AD
K
L
V
I
N
K
S
A
T
G
H
DN
S
I
W
V
N
F
LKKPSDKDTL
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
RAS
TR
VV
GFS
DV
TP
T
L
SVRKED
-------------------------------------------------------------------------------
GK
K
E
W
V
L
D
GY
QVAR
N
DGQGKA
A
AT
FM
H
IS
Y
N
NFITEVNNLN
K
RMGDLRDI
N
GEAG
T
W
V
R
L
L
N
GSGSA
D
GGF
T
D
H
YT
LL
Q
M
GAD
---
RKH
E
L
G
S
M
DLFTGV
M
A
TYTD
T
DA
SAGL
Y
SGKTKS
W
G
-----
G
G
F
YAS
G
LF
R
SG
--
AY
F
DLI
A
KYIH
NE
N
K
Y
DLNF
AG
A
G
K
QN
F
R
SHS
L
YAGAE
V
GYRYHL
T
--
DT
TF
V
EPQAELV
W
G
R
LQ
G
QT
F
N
W
NDS
GM
D
V
SM
R
RNSVN
PL
V
GRTGV
VS
GKTFSGKDW
S
L
TA
R
AG
LH
Y
E
FDL
TDSAD
V
H
L
K
D
A
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VGLNAR
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
AINANIRY
S
F
fig|656393.3.peg.911
Escherichia coli H299 (17-1088/1088)
E
D
N
D
A
PV
FFNASSGAP
-
L
Q
W
K
F
D
SS
TG
T
G
S
L
K
QG
SDE
Y
A
MHG
QKGS
----
DLN
A
GKNL
T
F
L
G
H
NG
Q
I
D
L
E
N
S
V
T
QGAG
S
L
T
F
TD
DYTV
TTSNGS
-
TW
T
GAGIIVD
K
D
AS
V
N
W
Q
VNGV
K
GDNLHK
I
G
E
GTL
V
V
Q
GTG
V
N
E
GGLKVGDGTVVLNQQAD
SS
G
HV
QAFS
S
V
N
IASGRPTVVL
A
D
NQ
QVNPD
N
---
I
S
WGYRGG
V
LD
V
NGN
D
LTFH
K
L
N
AAD
Y
GA
T
L
G
--
N
-
S
SDKT
A
N
I
T
LD
YQTR-----
----
PADVKV
N
E
WS
SSNR
GT
V
G
S
LY
IYN
NP
YTHTVDYF
ILK
TSS
YG
WFP
--
TGQVSNEH
W
EY
VG
HDQNS
A
QALLANR-
-
-
-
INNKGY
LY
HG
K
L
L
GN
I
N
FS
N
KATPGTTG-ALV
MDGS
A
N
M
-
S
GT
F
TQE
N
G
R
L
TI
QGHPVIHA
S
--------------------------
T
S
Q
S
I
A
NTVSSL
GD
N
SVLT
Q
P
T
S
F
TQ
D
DWENR
T
F
SFGS
L
V
L
K
D
T
D
F
G
L
G
RNA
T
L
NTT
I
Q
A
D
N
-
S
S
V
T
LG
D
SR
VF
I
D
K
K
DG
Q
G
------
TAFTLE
EG
T
S
V
A
TKDA
D
K
S
V
F
N
G
T
V
N
L
DNQ
S
V
L
N
I
-
NEI
F
N
GGI
Q
A
N
-
N
S
T
V
N
ISS
D
S
A
V
L
EN-
S
T
L
TS
-
TA
L
N
L
N
K
GA
NVL
A
SQ
SF
V
SDG
P
V
NIS-DAT
L
S
L
NSR
P
--DEVSHTLLPVYDYAGSWN
L
K
G
DDAR
L
NVGPYSMLS
G
N
I
NVQDK
-
GT
-
VTL
G
GEGELSP
DL
--------
TLQNQMLY
S
-----
L
F
-
NGYRNTWS
G
S
L
N
------
A
PD
A
T
VSM
T
D
T
Q
--
W
S
M
N
G
N
S
TAGN
M
KLNR
T
IVGFNG
--
GTSSFTT
LT
TDNLDAVQ
S
A
FVM
R
TD
LNK
AD
K
L
V
I
N
K
S
A
T
G
H
DN
S
I
W
V
N
F
LKKPSDKDTL
D
I
P
LV
S
AP
EA
T
AD
N
L
--
F
RAS
TR
VV
GFS
DV
TP
T
L
SVRKED
-------------------------------------------------------------------------------
GK
K
E
W
V
L
D
GY
QVAR
N
DGQGKA
A
AT
FM
H
IS
Y
N
NFITEVNNLN
K
RMGDLRDI
N
GEAG
T
W
V
R
L
L
N
GSGSA
D
GGF
T
D
H
YT
LL
Q
M
GAD
---
RKH
E
L
G
S
M
DLFTGV
M
A
TYTD
T
DA
SAGL
Y
SGKTKS
W
G
-----
G
G
F
YAS
G
LF
R
SG
--
AY
F
DLI
A
KYIH
NE
N
K
Y
DLNF
AG
A
G
K
QN
F
R
SHS
L
YAGAE
V
GYRYHL
T
--
DT
TF
V
EPQAELV
W
G
R
LQ
G
QT
F
N
W
NDS
GM
D
V
SM
R
RNSVN
PL
V
GRTGV
VS
GKTFSGKDW
S
L
TA
R
AG
LH
Y
E
FDL
TDSAD
V
H
L
K
D
A
A
GE
HQ
I
N
G
R
KD
G
RML
YG
VGLNAR
FG
DN
T
R
L
GLE
V
E
R
SAFGKYN
T
D
D
AINANIRY
S
F
fig|585396.4.peg.5723
Escherichia coli O111:H- str. 11128 (252-1263/1263)
L
K
K
N
F
S
Y
N
V
DMSGVQQ--
-
V
T
I
E
NG
KL
TG
T
G
S
D
T
T
D
IK-
-
-
---
----
----
---
-
N
K
D
L
I
F
T
G
G
-
G
N
I
L
LK
S
S
F
D
N
GAG
G
L
V
F
ND
KK
T
Y
QVNGED
F
T
F
K
GAG
V
D
T
R
N
G
ST
V
E
W
N
I
RYD
N
K
DNLHK
I
G
N
GTL
D
V
R
K
S
-
-
Q
N
TN
LK
I
G
E
G
L
V
I
L
-----
--
G
AE
K
T
F
N
N
I
Y
M
ASG
DG
TV
K
L
N
A
NN
A
L
N
G
D
D
YAG
V
F
F
TEN
GG
T
LDLNG
Y
D
QV
F
KY
I
A
A
T
D
S
G
T
T
I
T
--
N
T
N
KDKP
A
T
L
S
I
-
---------
----
------
-
-
--
----
--
-
-
-
--
---
--
--------
---
---
--
---
--
--------
-
--
--
-----
-
--------
-
-
-
NNTDSY
I
Y
HG
N
I
T
GN
TK
IT
H
SFDQKQQNDRLI
L
DG
N
I
N
T
-
T
ND
I
S
I
K
N
A
H
L
VM
QGH
ATN
HA
V
FRDGGFSCSFPAQLKWLCGTDYVAVI
Q
N
Q
E
K
S
VNQKQN
T
D
Y
KTNN
L
V
S
D
L
S
Q
P
DWE
R
R
T
F
NFGT
L
H
L
E
N
A
D
F
A
V
A
RNA
D
V
KGN
I
Y
A
K
N
-
S
S
V
M
LGS
DI
A
Y
I
D
L
H
S
G
K
NIINDGF
SFRKDI
RS
G
I
S
E
STAG
D
L
S
S
F
T
G
R
V
V
A
DN-
S
T
L
A
I
-
NNK
F
L
G
EF
T
A
E
N
K
S
K
V
S
V
K
S
R
DV
V
L
NTG
A
T
I
SN
D
S
T
LTL
E
K
D
S
RLT
A
NM
W
L
M
N
S
G
T
I
NVGENAE
L
N
I
QGY
P
IADK---FIPSIHDLG-NVK
M
T
A
SNAT
L
TAGNYAMFS
G
EL
TADNA
T
AV
R
VNL
G
SETST--
----------
--LSEFNP
N
PELTD
L
M
F
DKYNTSWT
G
K
I
S
------
A
LK
G
D
A
SM
V
NT
V
--
W
R
M
T
G
D
S
GLNT
L
KTSK
S
LTVFSS
--
-DNKFST
LT
VNDLTTSD
S
T
FV
L
R
S
D
STG
S
D
K
V
V
V
K
N
K
L
E
G
K
N
N
N
L
L
V
D
Y
VANDGKHNSL
N
F
E
LV
S
AP
KG
T
AA
DV
--
F
NSQ
T
Q
NV
GFS
DV
TP
V
I
EQKDSG
-------------------------------------------------------------------------------
EK
T
T
W
T
L
K
G
F
NAVA
N
QQSAEK
A
EN
FM
S
AG
Y
K
NF
L
A
EVNNLN
K
RMGDLRDI
N
GEAGAWARI
M
SG
T
GSA
S
GGFSDNYTHVQVG
V
D
---
K
KH
E
L
D
G
L
DLFTG
F
T
V
T
H
TDS
S
A
SADV
FSGKTKS
V
G
-----
A
G
L
YAS
A
M
F
D
SG
--
AY
I
DLIGKY
V
HHDN
E
Y
TATF
AG
L
G
T
R
DY
S
T
HSWYAGAE
A
GYRYH
V
T
--
ED
AW
IEPQAELVYG
S
VSG
KQ
F
A
W
KDQ
GM
H
LSMK
DKDYN
PLIGRTGV
DV
GK
S
FSGKDW
K
VTA
R
AG
LG
YQFDL
LANGE
T
V
LRD
A
SGE
KR
I
K
G
E
KDSRML
MS
VGLNA
E
IR
DN
V
R
F
GLE
F
EKSAFGKYN
V
D
N
A
V
NAN
F
RY
S
F
fig|585397.7.peg.1694
Escherichia coli ED1a (204-1236/1236)
Q
D
S
S
G
T
V
VPAVAGGD-
-
I
V
W
N
Y
S
KG
S
G
E
GTL
S
Q
D
GKV
W
K
M
N
G
FRGG
----
S
LN
D
GK
DI
T
F
G
G
K
-
G
T
V
V
LKD
D
V
V
QGAG
S
L
T
F
NG
DYTV
RPEGNQ
-
TW
V
G
G
GIIV
N
D
G
HR
V
D
W
M
VNG
L
A
GD
A
LHK
T
G
K
GTL
V
V
A
G
S
G
E
N
P
G
T
L
NT
GDGTV
I
L
A
Q
K
AD
AA
G
RV
R
AFS
E
V
R
I
V
SGRP
V
VVL
Q
D
SH
Q
IEG
D
R
---
I
R
WGYRGG
T
LD
I
NGN
D
M
TFHRL
A
AAD
E
GA
V
L
T
--
-
-
S
RAGS
A
T
V
R
LD
FSP------
----
------
-
-
--
----
--
-
-
-
--
---
--
--------
---
---
--
---
--
--------
-
--
--
-----
-
--------
-
-
-
SGQKAV
MW
HG
H
F
T
GN
LS
V-
-
-LNNTSSAVDFI
MDG
G
A
D
M
-
S
G
S
F
TQ
Q
G
G
G
L
YI
QGHPV
V
HA
V
--------------------------
S
S
E
A
V
A
AALRKQ
GD
N
SVLT
R
P
V
S
F
TQ
K
DWE
S
R
T
F
SIGQ
L
K
L
K
E
A
S
F
S
L
S
RNA
T
L
TGD
I
D
A
D
N
-
A
T
M
V
LGS
DS
LY
L
D
M
K
DG
T
G
------
SSSAPV
K
G
T
S
A
A
GGAS
G
T
S
T
F
R
G
N
V
N
M
RH-
S
S
L
T
V
-
RDH
F
T
G
S
I
T
A
S
D
-
S
R
I
V
V
N
S
E
N
V
R
L
EGD
S
R
L
TS
-
S
A
LT
V
S
DG
G
RLH
V
KG
GL
E
T
DG
G
V
TLD-GGT
L
L
V
DGG
S
VRNDVYERLLAWSEERGGLN
G
S
G
EY--
-
---------
-
D
F
MTGAA
-
--
-
---
-
-------
----------
--------
-
----G
L
L
-
RGY-----
-
-
V
R
------
G
SA
G
N
V
N
L
Q
N
A
T
--
W
M
M
T
G
N
S
SVKH
L
ESSG
S
ALYFSR
--
PGGEFHT
LT
AGSMDISD
S
V
L
VM
R
TD
LHH
S
D
Q
L
R
V
T
E
S
L
R
G
K
N
N
L
L
L
V
D
F
TERSDGQKAL
NI
P
LVTAP
AG
T
GA
DV
--
F
SVK
TR
DT
GFS
HI
TP
V
V
RAEQGT
GGTAWQLNVVQPETAAEPVVDEVSRPSLPVVMRQDAKTPNPVEAVSPLPSPVSAPSPAPEASVTDVLTGENTGESGEYR
DE
T
R
W
L
L
T
GY
RSTV
N
VSAVRD
A
GM
L
M
S
MG
H
R
NFI
N
EVNNLN
K
RMGDLRDI
N
GEAGAWARI
M
SG
T
GSA
G
GGFSDNYTHVQVGAD
---
K
KH
E
L
D
G
L
DLFTGVT
M
TYTDS
N
A
GSDT
FSGKTKS
V
G
-----
A
G
L
YAS
A
LF
D
SG
--
AY
I
DLIGKY
V
HHDN
E
Y
TATF
AG
L
G
T
KDY
G
SHSWYAGAE
V
GYRYH
V
T
--
ED
AW
IEPQAELVYG
A
VSG
KQ
F
S
W
KDQ
GM
S
LSMK
DKDYN
PLIGRTGV
DV
GK
S
FSGKDW
K
VTA
R
AG
LG
YQFDL
LANGE
T
V
LRD
A
SGE
KR
I
K
G
E
KD
G
RML
MS
VGLNA
E
VR
DN
I
R
F
GLE
F
EKSAFGKYN
V
D
N
A
V
NA
GF
RY
S
F
fig|585397.7.peg.2103
Escherichia coli ED1a (204-1236/1236)
Q
D
S
S
G
T
V
VPAVAGGD-
-
I
V
W
N
Y
S
KG
S
G
E
GTL
S
Q
D
GKV
W
K
M
N
G
FRGG
----
S
LN
D
GK
DI
T
F
G
G
K
-
G
T
V
V
LKD
D
V
V
QGAG
S
L
T
F
NG
DYTV
RPEGNQ
-
TW
V
G
G
GIIV
N
D
G
HR
V
D
W
M
VNG
L
A
GD
A
LHK
T
G
K
GTL
V
V
A
G
S
G
E
N
P
G
T
L
NT
GDGTV
I
L
A
Q
K
AD
AA
G
RV
R
AFS
E
V
R
I
V
SGRP
V
VVL
Q
D
SH
Q
IEG
D
R
---
I
R
WGYRGG
T
LD
I
NGN
D
M
TFHRL
A
AAD
E
GA
V
L
T
--
-
-
S
RAGS
A
T
V
R
LD
FSP------
----
------
-
-
--
----
--
-
-
-
--
---
--
--------
---
---
--
---
--
--------
-
--
--
-----
-
--------
-
-
-
SGQKAV
MW
HG
H
F
T
GN
LS
V-
-
-LNNTSSAVDFI
MDG
G
A
D
M
-
S
G
S
F
TQ
Q
G
G
G
L
YI
QGHPV
V
HA
V
--------------------------
S
S
E
A
V
A
AALRKQ
GD
N
SVLT
R
P
V
S
F
TQ
K
DWE
S
R
T
F
SIGQ
L
K
L
K
E
A
S
F
S
L
S
RNA
T
L
TGD
I
D
A
D
N
-
A
T
M
V
LGS
DS
LY
L
D
M
K
DG
T
G
------
SSSAPV
K
G
T
S
A
A
GGAS
G
T
S
T
F
R
G
N
V
N
M
RH-
S
S
L
T
V
-
RDH
F
T
G
S
I
T
A
S
D
-
S
R
I
V
V
N
S
E
N
V
R
L
EGD
S
R
L
TS
-
S
A
LT
V
S
DG
G
RLH
V
KG
GL
E
T
DG
G
V
TLD-GGT
L
L
V
DGG
S
VRNDVYERLLAWSEERGGLN
G
S
G
EY--
-
---------
-
D
F
MTGAA
-
--
-
---
-
-------
----------
--------
-
----G
L
L
-
RGY-----
-
-
V
R
------
G
SA
G
N
V
N
L
Q
N
A
T
--
W
M
M
T
G
N
S
SVKH
L
ESSG
S
ALYFSR
--
PGGEFHT
LT
AGSMDISD
S
V
L
VM
R
TD
LHH
S
D
Q
L
R
V
T
E
S
L
R
G
K
N
N
L
L
L
V
D
F
TERSDGQKAL
NI
P
LVTAP
AG
T
GA
DV
--
F
SVK
TR
DT
GFS
HI
TP
V
V
RAEQGT
GGTAWQLNVVQPETAAEPVVDEVSRPSLPVVMRQDAKTPNPVEAVSPLPSPVSAPSPAPEASVTDVLTGENTGESGEYR
DE
T
R
W
L
L
T
GY
RSTV
N
VSAVRD
A
GM
L
M
S
MG
H
R
NFI
N
EVNNLN
K
RMGDLRDI
N
GEAGAWARI
M
SG
T
GSA
G
GGFSDNYTHVQVGAD
---
K
KH
E
L
D
G
L
DLFTGVT
M
TYTDS
N
A
GSDT
FSGKTKS
V
G
-----
A
G
L
YAS
A
LF
D
SG
--
AY
I
DLIGKY
V
HHDN
E
Y
TATF
AG
L
G
T
KDY
G
SHSWYAGAE
V
GYRYH
V
T
--
ED
AW
IEPQAELVYG
A
VSG
KQ
F
S
W
KDQ
GM
S
LSMK
DKDYN
PLIGRTGV
DV
GK
S
FSGKDW
K
VTA
R
AG
LG
YQFDL
LANGE
T
V
LRD
A
SGE
KR
I
K
G
E
KD
G
RML
MS
VGLNA
E
VR
DN
I
R
F
GLE
F
EKSAFGKYN
V
D
N
A
V
NA
GF
RY
S
F
fig|585397.9.peg.1689
Escherichia coli ED1a (204-1236/1236)
Q
D
S
S
G
T
V
VPAVAGGD-
-
I
V
W
N
Y
S
KG
S
G
E
GTL
S
Q
D
GKV
W
K
M
N
G
FRGG
----
S
LN
D
GK
DI
T
F
G
G
K
-
G
T
V
V
LKD
D
V
V
QGAG
S
L
T
F
NG
DYTV
RPEGNQ
-
TW
V
G
G
GIIV
N
D
G
HR
V
D
W
M
VNG
L
A
GD
A
LHK
T
G
K
GTL
V
V
A
G
S
G
E
N
P
G
T
L
NT
GDGTV
I
L
A
Q
K
AD
AA
G
RV
R
AFS
E
V
R
I
V
SGRP
V
VVL
Q
D
SH
Q
IEG
D
R
---
I
R
WGYRGG
T
LD
I
NGN
D
M
TFHRL
A
AAD
E
GA
V
L
T
--
-
-
S
RAGS
A
T
V
R
LD
FSP------
----
------
-
-
--
----
--
-
-
-
--
---
--
--------
---
---
--
---
--
--------
-
--
--
-----
-
--------
-
-
-
SGQKAV
MW
HG
H
F
T
GN
LS
V-
-
-LNNTSSAVDFI
MDG
G
A
D
M
-
S
G
S
F
TQ
Q
G
G
G
L
YI
QGHPV
V
HA
V
--------------------------
S
S
E
A
V
A
AALRKQ
GD
N
SVLT
R
P
V
S
F
TQ
K
DWE
S
R
T
F
SIGQ
L
K
L
K
E
A
S
F
S
L
S
RNA
T
L
TGD
I
D
A
D
N
-
A
T
M
V
LGS
DS
LY
L
D
M
K
DG
T
G
------
SSSAPV
K
G
T
S
A
A
GGAS
G
T
S
T
F
R
G
N
V
N
M
RH-
S
S
L
T
V
-
RDH
F
T
G
S
I
T
A
S
D
-
S
R
I
V
V
N
S
E
N
V
R
L
EGD
S
R
L
TS
-
S
A
LT
V
S
DG
G
RLH
V
KG
GL
E
T
DG
G
V
TLD-GGT
L
L
V
DGG
S
VRNDVYERLLAWSEERGGLN
G
S
G
EY--
-
---------
-
D
F
MTGAA
-
--
-
---
-
-------
----------
--------
-
----G
L
L
-
RGY-----
-
-
V
R
------
G
SA
G
N
V
N
L
Q
N
A
T
--
W
M
M
T
G
N
S
SVKH
L
ESSG
S
ALYFSR
--
PGGEFHT
LT
AGSMDISD
S
V
L
VM
R
TD
LHH
S
D
Q
L
R
V
T
E
S
L
R
G
K
N
N
L
L
L
V
D
F
TERSDGQKAL
NI
P
LVTAP
AG
T
GA
DV
--
F
SVK
TR
DT
GFS
HI
TP
V
V
RAEQGT
GGTAWQLNVVQPETAAEPVVDEVSRPSLPVVMRQDAKTPNPVEAVSPLPSPVSAPSPAPEASVTDVLTGENTGESGEYR
DE
T
R
W
L
L
T
GY
RSTV
N
VSAVRD
A
GM
L
M
S
MG
H
R
NFI
N
EVNNLN
K
RMGDLRDI
N
GEAGAWARI
M
SG
T
GSA
G
GGFSDNYTHVQVGAD
---
K
KH
E
L
D
G
L
DLFTGVT
M
TYTDS
N
A
GSDT
FSGKTKS
V
G
-----
A
G
L
YAS
A
LF
D
SG
--
AY
I
DLIGKY
V
HHDN
E
Y
TATF
AG
L
G
T
KDY
G
SHSWYAGAE
V
GYRYH
V
T
--
ED
AW
IEPQAELVYG
A
VSG
KQ
F
S
W
KDQ
GM
S
LSMK
DKDYN
PLIGRTGV
DV
GK
S
FSGKDW
K
VTA
R
AG
LG
YQFDL
LANGE
T
V
LRD
A
SGE
KR
I
K
G
E
KD
G
RML
MS
VGLNA
E
VR
DN
I
R
F
GLE
F
EKSAFGKYN
V
D
N
A
V
NA
GF
RY
S
F
fig|585397.9.peg.2098
Escherichia coli ED1a (204-1236/1236)
Q
D
S
S
G
T
V
VPAVAGGD-
-
I
V
W
N
Y
S
KG
S
G
E
GTL
S
Q
D
GKV
W
K
M
N
G
FRGG
----
S
LN
D
GK
DI
T
F
G
G
K
-
G
T
V
V
LKD
D
V
V
QGAG
S
L
T
F
NG
DYTV
RPEGNQ
-
TW
V
G
G
GIIV
N
D
G
HR
V
D
W
M
VNG
L
A
GD
A
LHK
T
G
K
GTL
V
V
A
G
S
G
E
N
P
G
T
L
NT
GDGTV
I
L
A
Q
K
AD
AA
G
RV
R
AFS
E
V
R
I
V
SGRP
V
VVL
Q
D
SH
Q
IEG
D
R
---
I
R
WGYRGG
T
LD
I
NGN
D
M
TFHRL
A
AAD
E
GA
V
L
T
--
-
-
S
RAGS
A
T
V
R
LD
FSP------
----
------
-
-
--
----
--
-
-
-
--
---
--
--------
---
---
--
---
--
--------
-
--
--
-----
-
--------
-
-
-
SGQKAV
MW
HG
H
F
T
GN
LS
V-
-
-LNNTSSAVDFI
MDG
G
A
D
M
-
S
G
S
F
TQ
Q
G
G
G
L
YI
QGHPV
V
HA
V
--------------------------
S
S
E
A
V
A
AALRKQ
GD
N
SVLT
R
P
V
S
F
TQ
K
DWE
S
R
T
F
SIGQ
L
K
L
K
E
A
S
F
S
L
S
RNA
T
L
TGD
I
D
A
D
N
-
A
T
M
V
LGS
DS
LY
L
D
M
K
DG
T
G
------
SSSAPV
K
G
T
S
A
A
GGAS
G
T
S
T
F
R
G
N
V
N
M
RH-
S
S
L
T
V
-
RDH
F
T
G
S
I
T
A
S
D
-
S
R
I
V
V
N
S
E
N
V
R
L
EGD
S
R
L
TS
-
S
A
LT
V
S
DG
G
RLH
V
KG
GL
E
T
DG
G
V
TLD-GGT
L
L
V
DGG
S
VRNDVYERLLAWSEERGGLN
G
S
G
EY--
-
---------
-
D
F
MTGAA
-
--
-
---
-
-------
----------
--------
-
----G
L
L
-
RGY-----
-
-
V
R
------
G
SA
G
N
V
N
L
Q
N
A
T
--
W
M
M
T
G
N
S
SVKH
L
ESSG
S
ALYFSR
--
PGGEFHT
LT
AGSMDISD
S
V
L
VM
R
TD
LHH
S
D
Q
L
R
V
T
E
S
L
R
G
K
N
N
L
L
L
V
D
F
TERSDGQKAL
NI
P
LVTAP
AG
T
GA
DV
--
F
SVK
TR
DT
GFS
HI
TP
V
V
RAEQGT
GGTAWQLNVVQPETAAEPVVDEVSRPSLPVVMRQDAKTPNPVEAVSPLPSPVSAPSPAPEASVTDVLTGENTGESGEYR
DE
T
R
W
L
L
T
GY
RSTV
N
VSAVRD
A
GM
L
M
S
MG
H
R
NFI
N
EVNNLN
K
RMGDLRDI
N
GEAGAWARI
M
SG
T
GSA
G
GGFSDNYTHVQVGAD
---
K
KH
E
L
D
G
L
DLFTGVT
M
TYTDS
N
A
GSDT
FSGKTKS
V
G
-----
A
G
L
YAS
A
LF
D
SG
--
AY
I
DLIGKY
V
HHDN
E
Y
TATF
AG
L
G
T
KDY
G
SHSWYAGAE
V
GYRYH
V
T
--
ED
AW
IEPQAELVYG
A
VSG
KQ
F
S
W
KDQ
GM
S
LSMK
DKDYN
PLIGRTGV
DV
GK
S
FSGKDW
K
VTA
R
AG
LG
YQFDL
LANGE
T
V
LRD
A
SGE
KR
I
K
G
E
KD
G
RML
MS
VGLNA
E
VR
DN
I
R
F
GLE
F
EKSAFGKYN
V
D
N
A
V
NA
GF
RY
S
F
fig|585397.7.peg.2498
Escherichia coli ED1a (204-1236/1236)
Q
D
S
S
G
T
V
VPAVAGGD-
-
I
V
W
N
Y
S
KG
S
G
E
GTL
S
Q
D
GKV
W
K
M
N
G
FRGG
----
S
LN
D
GK
DI
T
F
G
G
K
-
G
T
V
V
LKD
D
V
V
QGAG
S
L
T
F
NG
DYTV
RPEGNQ
-
TW
V
G
G
GIIV
N
D
G
HR
V
D
W
M
VNG
L
A
GD
A
LHK
T
G
K
GTL
V
V
A
G
S
G
E
N
P
G
T
L
NT
GDGTV
I
L
A
Q
K
AD
AA
G
RV
R
AFS
E
V
R
I
V
SGRP
V
VVL
Q
D
SH
Q
IEG
D
R
---
I
R
WGYRGG
T
LD
I
NGN
D
M
TFHRL
A
AAD
E
GA
V
L
T
--
-
-
S
RAGS
A
T
V
R
LD
FSP------
----
------
-
-
--
----
--
-
-
-
--
---
--
--------
---
---
--
---
--
--------
-
--
--
-----
-
--------
-
-
-
SGQKAV
MW
HG
H
F
T
GN
LS
V-
-
-LNNTSSAVDFI
MDG
G
A
D
M
-
S
G
S
F
TQ
Q
G
G
G
L
YI
QGHPV
V
HA
V
--------------------------
S
S
E
A
V
A
AALRKQ
GD
N
SVLT
R
P
V
S
F
TQ
K
DWE
S
R
T
F
SIGQ
L
K
L
K
E
A
S
F
S
L
S
RNA
T
L
TGD
I
D
A
D
N
-
A
T
M
V
LGS
DS
LY
L
D
M
K
DG
T
G
------
SSSAPV
K
G
T
S
A
A
GGAS
G
T
S
T
F
R
G
N
V
N
M
RH-
S
S
L
T
V
-
RDH
F
T
G
S
I
T
A
S
D
-
G
R
I
V
V
N
S
E
N
V
R
L
EGD
S
R
L
TS
-
S
A
LT
V
S
DG
G
RLH
V
KG
GL
E
T
DG
G
V
TLD-GGT
L
L
V
DGG
S
VRNDVYERLLAWSEVRGGLN
G
S
G
EY--
-
---------
-
D
F
MTGAA
-
--
-
---
-
-------
----------
--------
-
----G
L
L
-
RGY-----
-
-
V
R
------
G
SA
G
N
V
N
L
Q
N
A
A
--
W
M
M
T
G
N
S
SVKH
L
ESSG
S
ALYFSR
--
PGGEFHT
LT
AGSMDISD
S
V
L
VM
R
TD
LHH
S
D
Q
L
R
V
T
E
S
L
R
G
K
N
N
L
L
L
V
D
F
TERSDGKKAL
NI
P
LVTAP
AG
T
GA
DV
--
F
SVK
TR
DT
GFS
HI
TP
V
V
RAEQGT
GGTAWQLNVVQPETAAEPVVDEVSRPSLPVVMRQDAKTPNPVEAVSPLPSPVSAPSPAPEASVTDVLTGENTGESGEYR
DE
T
R
W
L
L
T
GY
RSTV
N
VSAVRD
A
GM
L
M
S
MG
H
R
NFI
N
EVNNLN
K
RMGDLRDI
N
GEAGAWARI
M
SG
T
GSA
G
GGFSDNYTHVQVGAD
---
K
KH
E
L
D
G
L
DLFTGVT
M
TYTDS
N
A
GSDT
FSGKTKS
V
G
-----
A
G
L
YAS
A
LF
D
SG
--
AY
I
DLIGKY
V
HHDN
E
Y
TATF
AG
L
G
T
KDY
G
SHSWYAGAE
V
GYRYH
V
T
--
ED
AW
IEPQAELVYG
A
VSG
KQ
F
S
W
KDQ
GM
S
LSMK
DKDYN
PLIGRTGV
DV
GK
S
FSGKDW
K
VTA
R
AG
LG
YQFDL
LANGE
T
V
LRD
A
SGE
KR
I
K
G
E
KD
G
RML
MS
VGLNA
E
VR
DN
I
R
F
GLE
F
EKSAFGKYN
V
D
N
A
V
NA
GF
RY
S
F
fig|585397.9.peg.2495
Escherichia coli ED1a (204-1236/1236)
Q
D
S
S
G
T
V
VPAVAGGD-
-
I
V
W
N
Y
S
KG
S
G
E
GTL
S
Q
D
GKV
W
K
M
N
G
FRGG
----
S
LN
D
GK
DI
T
F
G
G
K
-
G
T
V
V
LKD
D
V
V
QGAG
S
L
T
F
NG
DYTV
RPEGNQ
-
TW
V
G
G
GIIV
N
D
G
HR
V
D
W
M
VNG
L
A
GD
A
LHK
T
G
K
GTL
V
V
A
G
S
G
E
N
P
G
T
L
NT
GDGTV
I
L
A
Q
K
AD
AA
G
RV
R
AFS
E
V
R
I
V
SGRP
V
VVL
Q
D
SH
Q
IEG
D
R
---
I
R
WGYRGG
T
LD
I
NGN
D
M
TFHRL
A
AAD
E
GA
V
L
T
--
-
-
S
RAGS
A
T
V
R
LD
FSP------
----
------
-
-
--
----
--
-
-
-
--
---
--
--------
---
---
--
---
--
--------
-
--
--
-----
-
--------
-
-
-
SGQKAV
MW
HG
H
F
T
GN
LS
V-
-
-LNNTSSAVDFI
MDG
G
A
D
M
-
S
G
S
F
TQ
Q
G
G
G
L
YI
QGHPV
V
HA
V
--------------------------
S
S
E
A
V
A
AALRKQ
GD
N
SVLT
R
P
V
S
F
TQ
K
DWE
S
R
T
F
SIGQ
L
K
L
K
E
A
S
F
S
L
S
RNA
T
L
TGD
I
D
A
D
N
-
A
T
M
V
LGS
DS
LY
L
D
M
K
DG
T
G
------
SSSAPV
K
G
T
S
A
A
GGAS
G
T
S
T
F
R
G
N
V
N
M
RH-
S
S
L
T
V
-
RDH
F
T
G
S
I
T
A
S
D
-
G
R
I
V
V
N
S
E
N
V
R
L
EGD
S
R
L
TS
-
S
A
LT
V
S
DG
G
RLH
V
KG
GL
E
T
DG
G
V
TLD-GGT
L
L
V
DGG
S
VRNDVYERLLAWSEVRGGLN
G
S
G
EY--
-
---------
-
D
F
MTGAA
-
--
-
---
-
-------
----------
--------
-
----G
L
L
-
RGY-----
-
-
V
R
------
G
SA
G
N
V
N
L
Q
N
A
A
--
W
M
M
T
G
N
S
SVKH
L
ESSG
S
ALYFSR
--
PGGEFHT
LT
AGSMDISD
S
V
L
VM
R
TD
LHH
S
D
Q
L
R
V
T
E
S
L
R
G
K
N
N
L
L
L
V
D
F
TERSDGKKAL
NI
P
LVTAP
AG
T
GA
DV
--
F
SVK
TR
DT
GFS
HI
TP
V
V
RAEQGT
GGTAWQLNVVQPETAAEPVVDEVSRPSLPVVMRQDAKTPNPVEAVSPLPSPVSAPSPAPEASVTDVLTGENTGESGEYR
DE
T
R
W
L
L
T
GY
RSTV
N
VSAVRD
A
GM
L
M
S
MG
H
R
NFI
N
EVNNLN
K
RMGDLRDI
N
GEAGAWARI
M
SG
T
GSA
G
GGFSDNYTHVQVGAD
---
K
KH
E
L
D
G
L
DLFTGVT
M
TYTDS
N
A
GSDT
FSGKTKS
V
G
-----
A
G
L
YAS
A
LF
D
SG
--
AY
I
DLIGKY
V
HHDN
E
Y
TATF
AG
L
G
T
KDY
G
SHSWYAGAE
V
GYRYH
V
T
--
ED
AW
IEPQAELVYG
A
VSG
KQ
F
S
W
KDQ
GM
S
LSMK
DKDYN
PLIGRTGV
DV
GK
S
FSGKDW
K
VTA
R
AG
LG
YQFDL
LANGE
T
V
LRD
A
SGE
KR
I
K
G
E
KD
G
RML
MS
VGLNA
E
VR
DN
I
R
F
GLE
F
EKSAFGKYN
V
D
N
A
V
NA
GF
RY
S
F
fig|340185.3.peg.3806
Escherichia coli E22 (327-1290/1290)
W
N
F
D
SQ
TG
T
G
S
L
T
QG
SQR
W
D
MHG
S---
VNGT
N
LN
N
GKNL
T
F
L
G
S
D
G
Q
M
M
L
N
N
A
V
D
QGAG
T
L
T
F
DA
N
YTV
SPSTNE
-
TW
K
G
G
GIIV
N
D
D
HT
V
D
W
Q
VNGV
K
GDNLHK
L
G
T
GTL
K
V
N
GTG
V
N
P
GGL
N
VG
E
GTV
I
L
A
Q
R
P
D
SD
G
NV
QAF
N
I
V
D
I
V
SGRPTVVL
S
D
DK
QVNPD
N
---
I
I
W
D
YRGG
K
LD
I
NGN
S
LTFH
Q
L
N
G
AD
D
GA
I
L
T
--
-
-
N
SGKQ
A
T
V
N
LD
FNKPNA---
----
------
-
-
--
----
--
-
-
-
--
---
--
--------
---
---
--
---
--
--------
-
--
--
-----
-
--------
-
-
-
TTTVAN
I
W
HG
H
F
T
GN
VD
VS
N
AATTSTQN-DFV
MDG
G
M
N
I
-
Q
G
S
F
TQ
Q
N
G
R
L
FI
QGHPVIHA
A
--------------------------
S
S
Q
A
V
A
NKLKTF
GD
N
SVLT
Q
P
V
S
F
TQ
S
DWENR
Q
F
SMTQ
L
N
L
N
N
A
D
F
S
L
A
RNA
S
L
STL
I
N
A
D
H
-
S
T
V
T
LGS
EN
LY
I
D
L
NDG
N
G
------
AKTTPS
F
G
Q
S
K
A
TNAA
D
Q
S
R
F
S
G
R
V
Q
L
KNG
S
T
L
N
I
-
NEH
F
V
GGI
D
S
A
D
-
S
S
V
T
V
A
S
T
D
A
L
F
SQY
S
R
F
RH
-
SSL
S
L
A
DGA
KLT
V
TS
GL
A
SD
R
G
V
TAGAGST
L
S
L
L--
S
GQ----Y-------AAERWS
L
A
G
QGTT
L
NVAAGATLA
G
N
I
QADNV
-
AS
-
INF
G
VTDQIGS
----------
--------
-
-----
-
-
-
VIRVTGYR
G
N
I
N
------
A
PL
A
D
V
T
M
T
N
I
G
--
W
Q
A
D
S
G
S
TVKS
L
DLKG
S
QVSFNQ
--
-TGGPGS
LT
VDDFVASN
S
Q
F
IV
N
TD
GKT
AD
T
V
T
V
K
Q
S
L
T
G
K
N
N
V
L
T
V
V
P
TALPVNNEVS
S
V
P
LVTAP
KS
T
SA
DV
L
TL
NPV
T
Q
HA
GF
H
TF
TP
Q
V
GIVESE
-------------------------------------------------------------------------------
DS
K
Q
W
L
L
E
G
F
DVQQ
D
KALLQS
G
KS
FM
D
ME
Y
K
NF
L
TE
M
NNLN
Y
RMGDLR
NT
L
GE
S
G
T
WARI
F
SG
T
GSA
E
A
G
Y
SD
S
W
TH
L
Q
I
GAD
---
RKH
T
F
D
G
A
DLFTGVT
A
T
F
T
N
S
N
R
HGDG
W
SG
Q
TKS
T
G
-----
V
G
V
Y
T
S
V
M
F
D
SG
--
L
Y
V
D
A
IGKY
VR
HDN
H
Y
SVSE
M
G
M
P
E
Q
DY
N
SHSWY
L
GAE
T
G
W
R
F
F
L
P
--
GE
TFI
Q
PQ
T
ELVYG
K
A
SG
NQ
F
A
W
QSA
G
S
D
I
R
M
Q
RDQMK
PLIGRTGV
ES
GKTF
R
GKDW
E
L
MT
V
AG
VH
YQ
Y
DL
FNPSK
T
V
V
H
D
F
A
G
D
TY
I
R
N
G
KD
N
R
VN
FS
L
G
V
N
T
R
IK
E
N
T
R
I
S
L
N
I
E
R
SAFG
H
Y
D
I
D
K
AINANIRY
S
F
fig|340185.4.peg.4006
Escherichia coli E22 (281-1244/1244)
W
N
F
D
SQ
TG
T
G
S
L
T
QG
SQR
W
D
MHG
S---
VNGT
N
LN
N
GKNL
T
F
L
G
S
D
G
Q
M
M
L
N
N
A
V
D
QGAG
T
L
T
F
DA
N
YTV
SPSTNE
-
TW
K
G
G
GIIV
N
D
D
HT
V
D
W
Q
VNGV
K
GDNLHK
L
G
T
GTL
K
V
N
GTG
V
N
P
GGL
N
VG
E
GTV
I
L
A
Q
R
P
D
SD
G
NV
QAF
N
I
V
D
I
V
SGRPTVVL
S
D
DK
QVNPD
N
---
I
I
W
D
YRGG
K
LD
I
NGN
S
LTFH
Q
L
N
G
AD
D
GA
I
L
T
--
-
-
N
SGKQ
A
T
V
N
LD
FNKPNA---
----
------
-
-
--
----
--
-
-
-
--
---
--
--------
---
---
--
---
--
--------
-
--
--
-----
-
--------
-
-
-
TTTVAN
I
W
HG
H
F
T
GN
VD
VS
N
AATTSTQN-DFV
MDG
G
M
N
I
-
Q
G
S
F
TQ
Q
N
G
R
L
FI
QGHPVIHA
A
--------------------------
S
S
Q
A
V
A
NKLKTF
GD
N
SVLT
Q
P
V
S
F
TQ
S
DWENR
Q
F
SMTQ
L
N
L
N
N
A
D
F
S
L
A
RNA
S
L
STL
I
N
A
D
H
-
S
T
V
T
LGS
EN
LY
I
D
L
NDG
N
G
------
AKTTPS
F
G
Q
S
K
A
TNAA
D
Q
S
R
F
S
G
R
V
Q
L
KNG
S
T
L
N
I
-
NEH
F
V
GGI
D
S
A
D
-
S
S
V
T
V
A
S
T
D
A
L
F
SQY
S
R
F
RH
-
SSL
S
L
A
DGA
KLT
V
TS
GL
A
SD
R
G
V
TAGAGST
L
S
L
L--
S
GQ----Y-------AAERWS
L
A
G
QGTT
L
NVAAGATLA
G
N
I
QADNV
-
AS
-
INF
G
VTDQIGS
----------
--------
-
-----
-
-
-
VIRVTGYR
G
N
I
N
------
A
PL
A
D
V
T
M
T
N
I
G
--
W
Q
A
D
S
G
S
TVKS
L
DLKG
S
QVSFNQ
--
-TGGPGS
LT
VDDFVASN
S
Q
F
IV
N
TD
GKT
AD
T
V
T
V
K
Q
S
L
T
G
K
N
N
V
L
T
V
V
P
TALPVNNEVS
S
V
P
LVTAP
KS
T
SA
DV
L
TL
NPV
T
Q
HA
GF
H
TF
TP
Q
V
GIVESE
-------------------------------------------------------------------------------
DS
K
Q
W
L
L
E
G
F
DVQQ
D
KALLQS
G
KS
FM
D
ME
Y
K
NF
L
TE
M
NNLN
Y
RMGDLR
NT
L
GE
S
G
T
WARI
F
SG
T
GSA
E
A
G
Y
SD
S
W
TH
L
Q
I
GAD
---
RKH
T
F
D
G
A
DLFTGVT
A
T
F
T
N
S
N
R
HGDG
W
SG
Q
TKS
T
G
-----
V
G
V
Y
T
S
V
M
F
D
SG
--
L
Y
V
D
A
IGKY
VR
HDN
H
Y
SVSE
M
G
M
P
E
Q
DY
N
SHSWY
L
GAE
T
G
W
R
F
F
L
P
--
GE
TFI
Q
PQ
T
ELVYG
K
A
SG
NQ
F
A
W
QSA
G
S
D
I
R
M
Q
RDQMK
PLIGRTGV
ES
GKTF
R
GKDW
E
L
MT
V
AG
VH
YQ
Y
DL
FNPSK
T
V
V
H
D
F
A
G
D
TY
I
R
N
G
KD
N
R
VN
FS
L
G
V
N
T
R
IK
E
N
T
R
I
S
L
N
I
E
R
SAFG
H
Y
D
I
D
K
AINANIRY
S
F
fig|550672.3.peg.4213
Escherichia coli B088 (298-1281/1281)
M
K
Q
D
A
D
A
PV
ISQRNKGD-
-
I
H
W
S
YD
ET
TG
I
GTL
T
QG
ASS
W
S
MHG
NPGL
TSPA
S
LN
S
GK
D
L
T
F
Q
G
G
-
G
S
V
V
L
E
N
T
V
D
QGAG
T
L
T
F
ND
DY
SI
KPLDSQ
-
TW
K
G
G
GII
I
N
G
D
SI
V
D
W
Q
VNGV
Q
GDNLHK
L
G
T
GTL
K
V
N
GTG
I
N
P
GGL
N
VG
E
GTV
I
L
A
Q
R
P
D
SN
G
NV
QAF
N
N
V
S
I
V
SGRPTVVL
S
D
AK
QVNPD
N
---
V
K
WGYRGG
K
LD
I
NGN
N
LTFH
K
L
N
G
AD
E
GA
V
L
T
--
-
-
N
SGSL
A
S
V
N
LD
FNKADA---
----
------
-
-
--
----
--
-
-
-
--
---
--
--------
---
---
--
---
--
--------
-
--
--
-----
-
--------
-
-
-
TTAVAN
I
W
HG
H
F
T
GN
ID
IN
N
TVTPGTQN-DFV
MDG
G
V
D
T
-
Q
G
S
F
TQE
N
G
R
L
FI
QGHPVIHA
V
--------------------------
S
T
Q
A
V
A
DKLKTL
GD
N
SVLT
Q
P
V
S
F
TQ
D
DWE
T
R
H
F
SMQQ
L
N
L
N
N
A
A
F
D
L
A
RNA
S
L
STN
I
N
A
N
H
-
S
T
V
T
LGS
ED
LY
I
D
I
NDG
N
G
------
VQTTPS
R
G
Q
S
K
A
TTET
D
Q
S
R
F
N
G
R
V
T
L
KNG
S
T
L
T
I
-
NEH
F
T
GGI
E
S
T
D
-
S
T
T
T
V
T
S
G
D
A
T
L
NVF
S
S
F
TR
-
S
A
L
A
L
A
DGA
NLT
A
TS
GL
I
SDG
E
V
TAGAGST
L
S
M
L--
S
GQ----Y-------TAGRWS
F
I
G
QGST
L
NVGAGSIMA
G
N
I
QANDA
-
AS
-
LSF
G
VTNQADQ
----------
--------
-
-----
-
-
-
NL-FTAYG
G
N
L
S
------
A
PL
A
R
V
M
M
T
NT
L
--
W
R
A
E
G
Q
S
VVKS
L
ELKG
A
QVSFSN
--
-VGAAGA
LT
VDTLTANN
S
M
F
II
N
T
N
GKT
AD
M
V
T
V
N
Q
S
L
N
G
K
N
N
S
L
V
V
V
P
TVSAAREATS
SL
P
LV
N
AP
KA
T
ES
DV
F
M
L
NPI
T
Q
RT
GF
H
TY
TP
Q
L
SMVETE
-------------------------------------------------------------------------------
NS
K
Q
W
R
L
E
G
F
DVQQ
D
KAAIQA
G
KS
V
M
D
VG
Y
K
S
F
L
TE
M
NNLN
Y
RMGDLR
NT
H
G
DT
G
T
WARI
Y
SG
T
GSA
D
A
G
Y
S
NS
W
TH
L
Q
I
GAD
---
RK
Q
S
F
N
G
G
DLFTGVT
A
T
F
T
N
S
N
S
HGTG
W
SG
Q
TKS
V
G
-----
I
G
L
YAS
T
M
F
D
SG
--
L
Y
V
D
V
IGKY
V
HHDN
H
Y
SATE
V
S
M
S
E
Q
DY
S
S
R
SWY
L
G
T
E
T
G
W
R
FS
L
P
--
GE
A
FIEPQ
T
ELVYG
A
VSG
NR
F
A
W
QSE
G
Y
D
I
SM
Q
RKQEN
PLIGRTGV
EI
GKTF
T
G
G
D
Y
K
L
TA
L
AG
VH
YQ
Y
DL
FNPEK
T
V
V
RD
L
A
GE
TF
I
R
N
G
KDSR
VN
FN
L
G
V
NA
E
IK
E
N
T
R
I
S
L
D
V
E
R
SA
S
G
H
Y
D
I
D
K
AINAN
V
RY
S
F
fig|656440.3.peg.3872
Escherichia coli TA206 (290-1255/1255)
IE
A
D
T
D
A
PV
TPTSTTEN-
-
I
N
W
T
YD
IS
TG
T
G
K
L
T
QG
TDA
W
E
MHG
RDTG
S
S
AVSF
N
H
GK
D
L
S
F
E
N
T
-
G
T
V
V
LKD
I
V
N
QGAG
T
I
T
F
NG
DY
L
V
KPDADQ
-
TW
V
G
G
GIIV
N
G
D
HT
V
N
W
Q
VNGV
K
GD
SM
HK
L
G
T
GTL
N
I
S
GTG
I
N
P
G
T
L
S
VGDGTVVL
A
Q
K
P
D
SN
G
QV
QAF
E
S
A
S
I
V
SGRPT
L
VL
S
D
SQ
Q
M
NPD
N
---
I
K
WGYRGG
K
LD
I
NGN
D
L
I
FH
A
L
N
AAD
E
GA
I
L
T
--
-
-
N
SGSL
A
T
A
N
LD
FNSTDT---
----
------
-
-
--
----
--
-
-
-
--
---
--
--------
---
---
--
---
--
--------
-
--
--
-----
-
--------
-
-
-
TKPVTT
M
FHG
F
F
T
GN
V
N
VK
N
NATSNVNN-TFV
V
DG
G
I
N
T
P
A
G
S
M
TQ
Q
G
G
R
L
FF
QGHPVIHA
V
--------------------------
S
T
Q
S
V
A
NKLKAL
GD
D
SVLT
Q
P
V
S
F
TQ
S
DW
Q
T
R
Q
F
NLKS
L
D
L
N
N
A
A
F
Y
L
A
RNA
G
L
TTT
I
N
A
N
N
-
S
T
V
T
LGS
ED
LY
I
D
T
NDG
N
G
------
VKTTPV
EG
Q
S
V
A
TASE
D
Q
S
H
F
T
G
N
V
N
L
TNG
S
A
L
R
V
-
NEN
F
S
GGI
I
S
S
N
-
S
S
V
T
ISS
T
N
A
N
L
TES
S
M
F
TH
-
S
V
I
K
L
S
D
N
A
QLT
S
TA
GL
Q
SDG
T
I
EFGNGAK
L
S
L
LGE
S
SSTFTPF-------SATAWN
L
K
G
TGST
L
NIGSGTNVN
GDI
NAWSD
-
TN
-
INF
G
NSGK-QS
----------
--------
-
-----
-
-
-
TSSGILYT
G
D
I
Y
------
A
PE
A
N
VS
I
D
NT
S
--
W
T
L
N
K
T
S
WLGN
L
TLK-
-
------
--
-------
-
-
-------N
S
Q
L
I
M
S
TD
GKT
S
S
A
I
K
V
V
D
T
F
S
G
E
N
N
I
L
Y
V
K
P
TRSLSEMSVS
NI
P
L
I
TA
-
KN
V
TN
N
TRA
F
KTV
T
Q
QT
GF
H
SM
TP
K
I
EVVNVD
-------------------------------------------------------------------------------
GT
T
Q
W
C
L
K
G
F
DVQS
D
STALKE
G
QR
L
MN
TN
I
K
NF
L
TEVNNLN
R
RMGDLRD
T
K
GE
T
GAWAR
L
M
N
S
SGS
G
Y
GGFSD
R
H
V
H
L
QVGAD
---
RKH
H
F
E
G
G
DLFTGV
M
M
T
V
TDS
K
A
SAES
Y
Q
GKT
R
S
V
G
-----
G
G
L
YAS
T
LF
D
SG
--
V
Y
V
D
V
IGKY
V
HH
S
N
D
Y
LLQT
M
G
L
K
A
D
D
-
T
A
HSWY
L
G
T
E
T
G
W
RY
QW
K
--
PD
V
FIEPQAELVYG
T
L
SG
NT
F
N
W
QYN
GM
D
V
SM
E
RKKAK
PLIGRTGV
EF
GKT
LD
G
R
DW
Q
VTA
K
AG
LS
YQFDL
RNTGA
T
T
Y
RD
F
A
GE
ST
V
Y
N
G
KD
G
RML
AN
I
G
ID
T
R
IK
DN
T
R
I
GL
T
V
EKSAFGKYN
V
D
N
AINANIRY
T
F
fig|439855.10.peg.4063
Escherichia coli SMS-3-5 (55-1020/1020)
IE
A
D
T
D
A
PV
TPTSTTEN-
-
I
N
W
T
YD
IS
TG
T
G
K
L
T
QG
TDA
W
E
MHG
RDTG
S
S
AVSF
N
H
GK
D
L
S
F
E
N
T
-
G
T
V
V
LKD
I
V
N
QGAG
T
L
T
F
NG
DY
I
V
KPDADQ
-
TW
V
G
G
GIIV
N
G
D
HT
V
N
W
Q
VNGV
K
GD
SM
HK
L
G
T
GTL
N
I
S
GTG
I
N
P
G
T
L
S
VGDGTVVL
A
Q
K
P
D
SN
G
QV
QAF
E
S
A
S
I
V
SGRPT
L
VL
S
D
SQ
Q
M
NPD
N
---
I
K
WGYRGG
K
LD
I
NGN
D
LTFH
A
L
N
AAD
E
GA
I
L
T
--
-
-
N
SGSL
A
T
T
S
LD
FNSTDT---
----
------
-
-
--
----
--
-
-
-
--
---
--
--------
---
---
--
---
--
--------
-
--
--
-----
-
--------
-
-
-
TKPVTT
M
FHG
F
F
T
GN
V
N
VK
N
NATSNVNN-TFV
V
DG
G
I
N
T
P
A
G
S
M
TQ
Q
G
G
R
L
FF
QGHPVIHA
V
--------------------------
S
T
Q
S
V
A
NKLKAL
GD
D
SVLT
Q
P
V
S
F
TQ
S
DW
Q
T
R
Q
F
NLKS
L
D
L
N
N
A
A
F
Y
L
A
RNA
G
L
ITT
I
N
A
N
N
-
S
T
V
T
LGS
ED
LY
I
D
T
NDG
N
G
------
VKTTPV
EG
Q
S
V
A
TASE
D
Q
S
H
F
T
G
N
V
N
L
TNG
S
A
L
R
V
-
NEN
F
S
GGI
I
S
S
N
-
S
S
V
T
ISS
T
N
A
N
L
TES
S
M
F
TH
-
S
V
I
K
L
S
D
N
A
QLT
S
TA
GL
Q
SDG
T
I
EFGNGAK
L
S
L
LGE
S
SSTFTPF-------SATAWN
L
K
G
TGSS
L
NIGSGTNVN
GDI
NAWSD
-
TN
-
INF
G
NSGK-QS
----------
--------
-
-----
-
-
-
TSSGILYT
G
D
I
Y
------
A
PE
A
N
VS
I
D
NT
S
--
W
T
L
N
K
T
S
LLGN
L
TLK-
-
------
--
-------
-
-
-------N
S
Q
L
I
M
S
TD
GKT
S
S
G
I
K
V
V
D
T
F
S
G
E
N
N
I
L
Y
V
K
P
TRSLSEMSVS
NI
P
L
I
TA
-
KN
V
TN
N
TRV
F
KTV
T
Q
QT
GF
H
SM
TP
K
I
EVVNVD
-------------------------------------------------------------------------------
GT
T
Q
W
R
L
K
G
F
DVQS
D
STALKE
G
QR
L
MN
TN
I
K
NF
L
TEVNNLN
R
RMGDLRD
T
K
GE
T
GAWAR
L
M
N
S
SGS
G
Y
GGFSD
R
H
V
H
L
QVGAD
---
RKH
H
F
E
G
G
DLFTGV
M
M
T
V
TDS
K
A
SAES
Y
Q
GKT
R
S
V
G
-----
G
G
L
YAS
T
LF
D
SG
--
V
Y
V
D
V
IGKY
V
HH
S
N
D
Y
LLQT
M
G
L
K
A
D
D
-
T
A
HSWY
L
GAE
T
G
W
RY
QW
K
--
PD
V
FIEPQAELVYG
T
L
SG
NT
F
N
W
QYN
GM
D
V
SM
E
RKKAK
PLIGRTGV
EF
GKT
LD
G
R
DW
Q
VTA
K
AG
LS
YQFDL
RNTGA
T
T
Y
RD
F
A
GE
ST
V
Y
N
G
KD
G
RML
AN
I
G
ID
T
R
IK
DN
T
R
I
GL
T
V
EKSAFGKYN
V
D
N
AINANIRY
T
F
fig|431946.3.peg.4172
Escherichia coli SE15 (295-1278/1278)
M
K
Q
D
A
D
A
PV
NTKQGEGD-
-
I
H
W
S
YD
EK
TG
L
G
S
L
T
QG
STS
W
E
MHG
NLGA
T
W
PA
S
LN
S
GK
D
L
T
F
Q
G
G
-
G
T
V
V
L
E
N
T
V
N
QGAG
T
L
T
F
DD
DY
I
V
KPVDTQ
-
TW
K
G
G
GIIV
N
G
E
HL
V
D
W
Q
I
NGV
T
GD
S
LHK
L
G
T
GTL
K
I
N
GTG
V
N
P
G
S
L
S
VGDGTV
I
L
A
Q
R
AD
DN
G
LS
QAFS
S
V
S
I
V
SGRPT
L
VL
N
D
DK
Q
I
NPD
N
---
I
K
WGY
H
GG
K
LD
I
NGN
S
LTFH
K
L
N
G
AD
D
GA
I
L
T
--
-
-
N
SGSM
A
N
V
N
LD
FNSPDT---
----
------
-
-
--
----
--
-
-
-
--
---
--
--------
---
---
--
---
--
--------
-
--
--
-----
-
--------
-
-
-
TATVAN
I
W
HG
H
F
T
GN
L
N
IN
N
EVTAGTQN-DFA
I
DG
G
V
N
T
-
Q
G
S
I
TQ
Q
N
G
R
L
FM
QGHPV
V
HA
V
--------------------------
S
S
Q
D
V
A
NKLKAL
GD
N
SVLT
Q
P
V
S
F
TQ
N
DWENR
Q
F
SMAE
L
N
L
Q
N
A
E
F
N
L
A
RNA
S
L
NTR
I
N
A
E
H
-
S
T
V
T
LGS
ED
LY
I
D
L
NDG
N
G
------
VATKPT
L
G
K
S
K
A
TAED
D
Q
S
R
F
N
G
H
V
Q
L
QQG
S
A
L
T
I
-
NEH
F
A
GGI
D
S
A
D
-
S
A
T
T
I
T
S
T
D
T
T
L
NQL
S
R
F
TQ
-
SSL
S
L
G
E
GA
KLT
A
TA
GL
L
SDG
T
V
SSNAGAS
L
S
L
L--
S
DQPGTMY-------SAQSWE
L
S
G
QDTS
L
NVGAGGIIT
GDI
NANDA
-
AS
-
ISF
G
TTDINQS
----------
--------
-
-----
-
-
-
----TNYY
G
N
I
N
------
A
PL
A
S
V
T
M
K
D
T
A
--
W
Q
V
N
K
Q
S
VAKS
L
TLNG
S
TLSFNR
--
-FG-QGG
LT
SDTLEATN
S
S
F
II
N
A
D
GKA
AD
T
V
T
V
N
Q
A
L
T
G
G
N
N
T
L
V
V
I
P
TTNSVKQGGD
P
V
S
LVTAP
KN
T
QS
N
I
FTL
NPV
S
I
NA
GF
H
SF
TP
Q
L
DVLETD
-------------------------------------------------------------------------------
VN
K
Q
W
R
L
E
G
F
YIQP
D
KAALRT
G
KS
FM
D
LG
Y
K
NFITE
I
NNLN
D
RMGDLR
H
T
H
GE
T
GAWAR
L
N
SGSGSA
T
D
GF
T
G
S
YTH
L
Q
I
GAD
---
RKH
I
I
E
G
G
E
LFTGVT
A
T
F
T
S
S
N
N
RGTG
W
SG
R
TKS
T
G
-----
I
G
V
YAS
A
M
F
D
SG
--
L
Y
V
D
T
IGKY
VR
HDN
H
Y
SSSA
L
G
M
P
E
Q
DY
G
SHSWY
L
GAE
A
G
W
R
FS
L
P
--
DE
T
Y
I
Q
PQ
T
EL
I
YG
T
VS
E
NQ
F
A
W
QFN
G
G
E
I
Y
M
Q
RKQMQ
PLIGRTG
I
EF
GKTF
R
GKDW
E
M
TA
L
T
G
IN
YQ
Y
DL
FKPTV
T
A
F
K
D
L
A
G
D
TY
I
N
N
G
KDSR
V
V
FN
VG
V
N
T
K
IK
E
N
T
R
I
S
L
N
V
E
R
S
E
FG
S
YN
I
D
K
L
INANIRY
T
F
fig|656417.3.peg.5218
Escherichia coli M605 (300-1283/1283)
M
K
Q
D
A
D
A
PV
NTKQGEGD-
-
I
H
W
S
YD
EK
TG
L
G
S
L
T
QG
STS
W
E
MHG
NLGA
T
W
PA
S
LN
S
GK
D
L
T
F
Q
G
G
-
G
T
V
V
L
E
N
T
V
N
QGAG
T
L
T
F
DD
DY
I
V
KPVDTQ
-
TW
K
G
G
GIIV
N
G
E
HL
V
D
W
Q
I
NGV
T
GD
S
LHK
L
G
T
GTL
K
I
N
G
I
G
V
N
P
G
S
L
S
VGDGTV
I
L
A
Q
R
AD
DN
G
LS
QAFS
S
V
S
I
V
SGRPT
L
VL
N
D
DK
Q
I
NPD
N
---
I
K
WGY
H
GG
K
LD
I
NGN
S
LTFH
K
L
N
G
AD
D
GA
I
L
T
--
-
-
N
SGSM
A
N
V
N
LD
FNSPDT---
----
------
-
-
--
----
--
-
-
-
--
---
--
--------
---
---
--
---
--
--------
-
--
--
-----
-
--------
-
-
-
TATIAN
I
W
HG
H
F
T
GN
L
N
IN
N
EVTAGTQN-DFA
I
DG
G
V
N
A
-
Q
G
S
I
TQ
Q
N
G
R
L
FM
QGHPV
V
HA
V
--------------------------
S
S
Q
D
V
A
NKLKAL
GD
N
SVLT
Q
P
V
S
F
TQ
N
DWENR
Q
F
SMAE
L
N
L
Q
N
A
E
F
N
L
A
RNA
S
L
NTR
I
N
A
D
H
-
S
T
V
T
LGS
ED
LY
I
D
L
NDG
N
G
------
VATKPT
L
G
K
S
K
A
TAED
D
Q
S
R
F
N
G
H
V
Q
L
QQG
S
A
L
T
I
-
NEH
F
A
GGI
D
S
A
D
-
S
A
T
T
I
T
S
T
D
T
T
L
NQL
S
R
F
TQ
-
SSL
S
L
G
E
GA
KLT
A
TA
GL
L
SDG
T
V
SSNAGAS
L
S
L
L--
S
DQPGTMY-------SAQSWE
L
S
G
QDTS
L
NVGAGGIIT
GDI
NANDA
-
AS
-
ISF
G
TTDINQS
----------
--------
-
-----
-
-
-
----TNYY
G
N
I
N
------
A
PL
A
S
V
T
M
K
D
T
A
--
W
Q
V
N
K
Q
S
VAKS
L
TLNG
S
TLSFNR
--
-FG-QGG
LT
SDTLEATN
S
S
F
II
N
A
D
GKA
AD
T
V
T
V
N
Q
A
L
T
G
G
N
N
T
L
V
V
I
P
TTNSVKQGGD
P
V
S
LVTAP
KN
T
QS
N
I
FTL
NPV
S
I
NA
GF
H
SF
TP
Q
L
DVLETD
-------------------------------------------------------------------------------
VN
K
Q
W
R
L
E
G
F
YIQP
D
KAALRT
G
KS
FM
D
LG
Y
K
NFITE
I
NNLN
D
RMGDLR
H
T
H
GE
T
GAWAR
L
N
SGSGSA
T
D
GF
T
G
S
YTH
L
Q
I
GAD
---
RKH
I
I
E
G
G
E
LFTGVT
A
T
F
T
S
S
N
N
RGTG
W
SG
R
TKS
T
G
-----
I
G
V
YAS
A
M
F
D
SG
--
L
Y
V
D
T
IGKY
VR
HDN
H
Y
SSSA
L
G
M
P
E
Q
DY
G
SHSWY
L
GAE
A
G
W
R
FS
L
P
--
DE
T
Y
I
Q
PQ
T
EL
I
YG
T
VS
E
NQ
F
A
W
QFN
G
G
E
I
Y
M
Q
RKQMQ
PLIGRTG
I
EF
GKTF
R
GKDW
E
M
TA
L
T
G
IN
YQ
Y
DL
FKPTV
T
A
F
K
D
L
A
G
D
TY
I
N
N
G
KDSR
V
V
FN
VG
V
N
T
K
IK
E
N
T
R
I
S
L
N
V
E
R
S
E
FG
S
YN
I
D
K
L
INANIRY
T
F
fig|550676.3.peg.2951
Escherichia coli B185 (306-1299/1299)
E
D
N
D
A
PV
TFRTSEGGA
-
L
E
W
S
F
N
SS
TG
A
G
A
L
T
QG
STT
Y
A
MHG
QQGN
----
DLN
A
GKNL
I
F
Q
G
Q
NG
Q
I
N
LKD
S
V
S
QGAG
S
L
T
F
RD
N
YTV
TTSNGS
-
TW
T
GAGIIVD
N
G
VS
V
N
W
Q
VNGV
K
GDNLHK
I
G
E
GTL
T
V
Q
GTG
I
N
E
GGLKVGDG
K
VVLNQQAD
NK
G
QV
QAFS
S
V
N
IASGRPTVVL
T
D
ER
QVNPD
T
---
V
S
WGYRGG
T
LD
V
NGN
S
LTFH
Q
L
K
AAD
Y
GA
V
L
A
--
N
-
N
ADKR
A
T
I
T
LD
YALR-----
----
ADKVAL
N
G
WS
ESRK
GT
A
G
N
LY
KYN
NP
YTNTTDYF
ILK
QST
YG
YFP
--
TDQSSNAT
W
EF
VG
HSQGD
A
QKLVADR-
-
-
-
FNAAGY
L
FHG
Q
L
K
D
N
L
N
VD
N
RLPEGVTG-ALV
MDGS
A
D
I
-
S
GT
F
TQE
N
G
R
L
TL
QGHPVIHA
Y
--------------------------
N
T
Q
S
V
A
DKLAAS
GD
H
SVLT
Q
P
T
S
F
S
Q
E
DWENR
S
F
TFDR
L
S
L
K
N
T
D
F
G
L
G
RNA
T
L
NTM
L
E
A
T
D
-
S
T
V
T
LG
D
RR
VF
I
D
K
NDG
N
G
------
TAFVLE
EG
T
S
E
A
VKDA
D
R
S
V
F
N
G
S
A
V
L
NGK
T
T
L
D
I
M
NAT
F
N
G
D
I
S
G
H
VG
S
H
V
E
L
S
R
R
SH
-
-
WN-
M
T
K
SS
-
T
LD
S
F
R
SK
G
GTL
-
--
SF
V
T
D
-
-
-
NWS-PKT
L
T
V
NTL
-
--------------HASSMN
I
A
-
----
M
GVSTADNTG
DR
I
DILNK
-
AT
-
---
G
GHNTL--
DL
SSLFDQTV
TLKNDLTL
A
SAPVG
T
S
-
HGYFSF--
A
S
L
N
RGFTVYT
PD
T
Q
V
QE
K
D
G
R
VY
W
Q
L
K
S
H
A
----
-
----
-
------
--
GTTE-SQ
VS
TDVSDDV-
-
-
---
-
--
---
T
D
T
T
S
P
V
A
P
D
T
G
S
TG
S
T
E
A
D
V
IVSEGNNSNG
VS
P
SPD
S
P
AE
N
AG
T
M
--
V
NGS
T
L
FK
G
AD
NT
S
L
L
K
KARAMF
-------------------------------------------------------------------------------
AA
R
EF
I
L
S
D-
----
-
------
-
--
---
-S
A
D
R
W
TQV
V
D
N
--
-
-----S
D
A
D
G
--
GAWA
M-
-
--
T
G
Y
S
H
GG
Y
-
D
DFS
L
N
Q
S
G
L
N
VGF
R
Q
S
A
A
G
-
-
N
A
W
W
G
M
G
A
E
F
YRGH
S
STDD
Y
R
DDFSL
W
G
VHVLA
G
K
S
F
A
A
G
LF
V
D
G
MTG
Y
R
E
L
SED
Y
TIQGE
L
S
DL--
--
S
G
R
A--
K
SH
I
L
T
AG
IR
G
G
W
K
M
H
A
A
PL
DM
S
-
I
T
P
TVS
L
NGA
R
V
D
G
NR
L
-
-
--Q
G
R
E
R
S
VE
LHDGD
A
L
WL
K
A
GV
EA
E
K
V-
SG
---
N
M
T
L
K
AG
IW
RNIT
L
NDMPG
M
T
LRD
D
WKA
RH
Y
D
A
E
K
AD
R
YT
VS
F
G
I
N
G
K
LT
E
K
L
S
V
QA
K
V
NS
S
FD
G
Y
F
K
T
D
A
EGIL
G
IRY
D
F
Consen1
Primary consensus
mq
D
d
pv
-
l
W
yd
tG
GtL
Qg
w
MhG
----
dLN
GKnl
F
G
nG
i
Lkd
V
QGAG
L
F
dYtV
-
TW
GaGIIvd
g
V
W
VNGv
GDnLHK
G
GTL
v
GtG
N
GgLkvGdGtVvLnQqaD
G
qAFs
v
iaSGRPtVVL
D
QvnpD
---
i
WGYRGG
LDlNGN
lTFhrL
aAD
GA
l
--
n
-
n
a
v
LD
----
-
--
gt
g
ly
--
ilk
yg
--
w
vg
a
-
-
ifHG
l
GNmn
-
mDGs
n
-
Gt
tqe
G
L
QGHPViHA
--------------------------
s
s
a
gd
svlt
p
s
tQ
DWEnR
F
L
L
da
F
L
RNA
l
I
a
n
-
s
v
LGs
vf
D
nDG
G
------
eG
S
a
d
S
f
G
v
l
S
L
i
-
F
GgI
a
d
-
S
v
isS
dv
l
s
f
-
ssLtl
dga
a
gl
sdG
v
l
l
p
l
G
l
gdi
-
-
g
----------
s
l
-
g
i
------
a
a
Vsm
nt
--
W
m
g
S
l
s
--
Lt
S
fvm
td
aD
l
v
e
a
G
dN
l
V
f
ni
LvtAP
t
nm
--
f
Tr
GFs
TP
l
-------------------------------------------------------------------------------
tkW
L
Gy
n
a
fMn
y
nFitEvNNLN
RMGDLRdi
GeaGaWaRi
sGsGSA
gGfsDnyThvQvGaD
---
rKH
l
g
DLFTGvt
TyTdsda
fsGkTKS
G
-----
G
YAS
lF
SG
--
aY
DlIgKYihhdN
Y
ag
g
kdy
sHSwYaGAE
GyRyhl
--
tfiePQaELVyG
vsG
F
W
gm
lsMk
PLiGRTGv
GKtFsGkDW
vTA
AG
yqfDL
t
lrD
sGe
i
g
KDsRml
vGlNar
dN
R
gLe
EkSAFGkYN
D
AiNAniRY
F
Consen2
Secondary consensus
k
s
ti
i
f
d
y
n
tspa
di
-
v
n
i
g
tn
d
l
i
s
t
nt
e
k
i
a
p
r
n
i
lv
v
ieg
v
t
g
i
-
s
s
svp
n
ws
--
-
--
np
---
--
wg
-
--
-
l
g
f
n
g
d
p
s
s
v
t
a
-
--
----
-
-
t
m
s
hga
d
ly
k
p
g
y
i
m
v
s
s
-
n
i
v
a
f
g
l
ta
v
kwg
v
sf
ts
i
i
v
s
g
-
-
nf
-
dl
-
-
-
g
g
l
d
k
m
t
-
l
an
s
i
l
n
i
p
v
is
s
ftl
q
h
ggtawqlnvvqpetaaepvvdevsrpslpvvmrqdaktpnpveavsplpspvsapspapeasvtdvltgentgesgeyr
k
f
d
g
l
h
s
m
nt
dt
t
v
l
n
a
yt
w
ll
f
k
f
s
fm
nt
s
r
q
m
l
v
a
vrne
ms
p
f
t
l
l
w
fsv
awvq
t
w
lq
ds
y
v
i
s
r
g
wey
v
vk
a
d
f
n
g
vn
l
t
e
s
n
r
h
v
gf
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character