┌─ Escherichia coli (85-213/216) M605   
                                               ┌┴─ Escherichia coli (85-213/216) B171 (8) [2] 
                                              ┌┴┬─ Escherichia coli (94-210/213) 53638 (23) [2] 
                                    ┌─────────┤ └─ Escherichia coli (94-213/216) 101-1   
                                    │         └─┬─ Escherichia coli (94-213/216) MS 182-1   
            ┌───────────────────────┤           └─ Escherichia coli (94-213/216) H299 (1)  
            │                       └─────┬─ Escherichia coli (93-222/225) B171 (2)  
            │                             └┬─ Escherichia coli (93-222/225) 2362-75   
┌───────────┤                              └─ Escherichia coli (106-235/238) E22 (25)  
│           │                                                 ┌─ Escherichia coli (90-222/225) 55989 (1)  
│           │                                                ┌┴─ Escherichia coli (90-225/225) M605   
│           └───────────────────────────────────────┬────────┴─ Escherichia coli (86-218/221) TA280   
│                                                   └──────┬─ Escherichia coli (91-224/224) 1044A (24)  
│                                                          └┬─ Escherichia coli (91-224/224) O55:H7 str. CB9615   
│                                                           └┬─ Escherichia coli (91-224/224) TA271   
│                                                            └─ Escherichia coli (110-243/243) E2348/69 (7)  
│                                                         ┌─ Escherichia coli (23-131/133) 536 (1)  
│                                                        ┌┴─ Escherichia coli (23-131/133) B7A (6)  
│                                                       ┌┴┬── Escherichia coli (23-131/133) 042   
┤                                                      ┌┤ └─ Escherichia coli (23-131/133) 55989 (127)  
│                                                      │└┬─ Escherichia coli (23-131/133) S88   
│                                                     ┌┤ └─ Escherichia coli (23-131/133) B7A (3)  
│                                                    ┌┤└─ Escherichia coli (23-131/133) O157:H7 EDL933   
│                                                    │└┬─ Escherichia coli (23-131/133) O157:H7 str. EC4196   
│                                                 ┌──┤ └─ Escherichia coli (23-131/133) O157:H7 (78)  
│                          ┌──────────────────────┤  └─────── Escherichia coli (23-131/133) NC101   
│           ┌──────────────┤                      └─── Escherichia coli (19-126/128) MS 115-1   
│           │              └───────────┬─ Escherichia coli (17-132/134) H299   
│           │                          └┬─ Escherichia coli (17-132/134) MS 21-1   
│           │                           └┬─ Escherichia coli (17-132/134) O26:H11 str. 11368 (1)  
│           │                            └─ fig|1040638.4.peg.210 O104:H4 (17-132/134) str. LB226692 (50)  
└───────────┤                                          ┌─ fig|1040638.4.peg.2517 O104:H4 str. LB226692 (11) [2] 
            │                                         ┌┴── Escherichia coli (2-125/125) B088   
            │                       ┌─────────────────┴─ Escherichia coli TA280   
            │                  ┌────┴───────────────────────────────┬─ Escherichia coli (8-133/136) TA271   
            │                  │                                    └─ Escherichia coli (8-133/136) MS 182-1   
            │                  │            ┌─ Escherichia coli (11-141/141) 536   
            └──────────────────┤          ┌─┴──── Escherichia coli (15-145/145) F11   
                               │         ┌┴┬─ Escherichia coli (11-131/131) MS 198-1   
                               │      ┌──┤ └─ Escherichia coli (11-141/141) ABU 83972   
                               │      │  └┬─ Escherichia coli (8-141/141) O157:H7 EDL933 (1)  
                               └──────┤   └─ Escherichia coli (8-141/141) O157:H7 (1)  
                                      │   ┌─ Escherichia coli (5-141/141) O157:H7 EDL933   
                                      │  ┌┴─ Escherichia coli (5-141/141) 1044A (6)  
                                      └──┤  ┌─ Escherichia coli (5-141/141) HS   
                                         └──┤┌─ Escherichia coli (10-144/144) E110019   
                                            └┤┌─ fig|1040638.4.peg.682 O104:H4 (5-141/141) str. LB226692 (10)  
                                             └┤┌─ Escherichia coli (5-141/141) H299   
                                              └┤┌─ Escherichia coli (5-141/141) S88   
                                               └┤ ┌─ Escherichia coli (5-141/141) ED1a (1)  
                                                └┬┴─ Escherichia coli (5-141/141) EC4100B   
                                                 └┬─ Escherichia coli (5-141/141) E110019 (1)  
                                                  └┬── Escherichia coli (5-141/141) B171 (3)  
                                                   └─ fig|1040638.4.peg.979 O104:H4 (5-141/141) str. LB226692   
  
ISSfl3 orfA (15)
IS, phage, Tn; Transposon-related functions (12)
hypothetical protein (11)
unknown in ISEc8 (5)
Insertion Sequence Associated (3)
unknown in putative ISEc8 (1)
putative transposase (1)
Unknown in ISEc8 (1)
Unknown protein encoded by ISEc8 (1)
Others (4)