fig|1040638.4.peg.2368
Escherichia coli O104:H4 str. LB226692
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|6666666.5357.peg.2249
Escherichia coli TY-2482
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|585055.6.peg.3475
Escherichia coli 55989
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|585055.8.peg.3478
Escherichia coli 55989
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|550672.3.peg.3270
Escherichia coli B088
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|344601.3.peg.451
Escherichia coli B171
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|344601.5.peg.450
Escherichia coli B171
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|340184.3.peg.2616
Escherichia coli B7A
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|340184.6.peg.2738
Escherichia coli B7A
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|331111.12.peg.3762
Escherichia coli E24377A
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|331111.3.peg.1179
Escherichia coli E24377A
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|656408.3.peg.3427
Escherichia coli H591
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|585034.4.peg.3109
Escherichia coli IAI1
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|585034.5.peg.3107
Escherichia coli IAI1
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|595495.4.peg.905
Escherichia coli KO11
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|679207.4.peg.3738
Escherichia coli MS 107-1
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|679206.4.peg.1382
Escherichia coli MS 119-7
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|679204.3.peg.747
Escherichia coli MS 145-7
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|749545.3.peg.1787
Escherichia coli MS 182-1
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|585395.4.peg.3869
Escherichia coli O103:H2 str. 12009
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|585396.4.peg.3984
Escherichia coli O111:H- str. 11128
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|573235.3.peg.4224
Escherichia coli O26:H11 str. 11368
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|409438.11.peg.3476
Escherichia coli SE11
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|656443.3.peg.4020
Escherichia coli TA271
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|566546.3.peg.582
Escherichia coli W
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|566546.4.peg.3256
Escherichia coli W
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|340186.3.peg.510
Escherichia coli E110019
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|340186.5.peg.533
Escherichia coli E110019
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|340185.3.peg.391
Escherichia coli E22
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
V
Q
L
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|340185.4.peg.430
Escherichia coli E22
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
V
Q
L
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
I
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|585057.4.peg.3641
Escherichia coli IAI39
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|585057.6.peg.3649
Escherichia coli IAI39
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
YG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|656419.3.peg.3999
Escherichia coli M718
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|562.371.peg.2324
Escherichia coli 1044A
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
V
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|562.373.peg.1801
Escherichia coli 1125A
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
V
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|562.372.peg.2519
Escherichia coli 1212A
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
V
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|562.374.peg.4595
Escherichia coli 536A
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
V
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|155864.1.peg.3909
Escherichia coli O157:H7 EDL933
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
V
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|155864.8.peg.3832
Escherichia coli O157:H7 EDL933
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
V
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|444454.5.peg.2957
Escherichia coli O157:H7 str. EC4024
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
V
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|444449.5.peg.2415
Escherichia coli O157:H7 str. EC4042
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
V
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|444448.5.peg.1168
Escherichia coli O157:H7 str. EC4045
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
V
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|444453.5.peg.3296
Escherichia coli O157:H7 str. EC4076
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
V
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|444452.5.peg.608
Escherichia coli O157:H7 str. EC4113
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
V
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|444450.8.peg.4252
Escherichia coli O157:H7 str. EC4115
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
V
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|444451.5.peg.1028
Escherichia coli O157:H7 str. EC4196
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
V
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|444447.5.peg.1325
Escherichia coli O157:H7 str. EC4206
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
V
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|478004.5.peg.853
Escherichia coli O157:H7 str. EC4401
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
V
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|478005.5.peg.1190
Escherichia coli O157:H7 str. EC4486
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
V
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|478006.5.peg.742
Escherichia coli O157:H7 str. EC4501
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
V
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|478007.5.peg.475
Escherichia coli O157:H7 str. EC508
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
V
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|478008.5.peg.1225
Escherichia coli O157:H7 str. EC869
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
V
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|637388.3.peg.5117
Escherichia coli O157:H7 str. FRIK2000
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
V
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|570506.3.peg.721
Escherichia coli O157:H7 str. FRIK966
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
V
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|544404.4.peg.4061
Escherichia coli O157:H7 str. TW14359
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
V
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|502346.5.peg.3351
Escherichia coli O157:H7 str. TW14588
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
V
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|701177.3.peg.3763
Escherichia coli O55:H7 str. CB9615
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
V
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|749532.3.peg.645
Escherichia coli MS 78-1
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|749531.3.peg.70
Escherichia coli MS 69-1
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
E
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|656393.3.peg.4063
Escherichia coli H299
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GDK
D
Q
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
N
I
D
VRL
TLNAN
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
S
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
T
K
V
SW
fig|550677.3.peg.3583
Escherichia coli B354
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
S
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|749548.3.peg.742
Escherichia coli MS 196-1
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAV
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
E
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|413997.3.peg.3035
Escherichia coli B str. REL606
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|511693.5.peg.3044
Escherichia coli BL21
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|469008.4.peg.730
Escherichia coli BL21(DE3)
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|595496.3.peg.3003
Escherichia coli BW2952
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|536056.3.peg.706
Escherichia coli DH1
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|316401.4.peg.3744
Escherichia coli ETEC H10407
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|656379.3.peg.3762
Escherichia coli FVEC1302
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|656380.3.peg.3683
Escherichia coli FVEC1412
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|656414.3.peg.3488
Escherichia coli H736
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|331112.3.peg.2995
Escherichia coli HS
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|331112.6.peg.3130
Escherichia coli HS
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|83333.1.peg.2973
Escherichia coli K12
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|749537.3.peg.688
Escherichia coli MS 115-1
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|749538.3.peg.3882
Escherichia coli MS 116-1
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|749540.3.peg.274
Escherichia coli MS 146-1
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|749549.3.peg.5097
Escherichia coli MS 198-1
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|585056.7.peg.3684
Escherichia coli UMN026
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|316407.3.peg.2912
Escherichia coli W3110
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|316385.5.peg.3152
Escherichia coli str. K-12 substr. DH10B
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|316385.7.peg.3222
Escherichia coli str. K-12 substr. DH10B
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|511145.12.peg.3119
Escherichia coli str. K-12 substr. MG1655
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|511145.6.peg.3104
Escherichia coli str. K-12 substr. MG1655
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|656444.3.peg.4270
Escherichia coli TA280
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
L
F
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
S
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|749547.3.peg.3968
Escherichia coli MS 187-1
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HID
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|562.376.peg.3883
Escherichia coli WV_060327
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAN
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
DFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|550676.3.peg.3180
Escherichia coli B185
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|358709.5.peg.1215
Escherichia coli 101-1
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
T
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|481805.3.peg.713
Escherichia coli ATCC 8739
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QQ
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|481805.6.peg.711
Escherichia coli ATCC 8739
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QQ
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|679205.4.peg.485
Escherichia coli MS 124-1
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|344610.3.peg.819
Escherichia coli 53638
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FAHTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|344610.7.peg.3222
Escherichia coli 53638
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FAHTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|216592.1.peg.3934
Escherichia coli 042
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DI
T
L
NA
D
----
S
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
V
E
Q
GG
FE
T
K
V
SW
fig|216592.3.peg.3442
Escherichia coli 042
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DI
T
L
NA
D
----
S
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
V
E
Q
GG
FE
T
K
V
SW
fig|656437.3.peg.3434
Escherichia coli TA143
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DI
T
L
NA
D
----
S
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
V
E
Q
GG
FE
T
K
V
SW
fig|362663.8.peg.3139
Escherichia coli 536
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
C
V
V
DV
T
L
NA
D
----
N
F
IV
K
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
D
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|362663.9.peg.3150
Escherichia coli 536
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
C
V
V
DV
T
L
NA
D
----
N
F
IV
K
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
D
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|670888.3.peg.3231
Escherichia coli 1827-70
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EDFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
S
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|670897.3.peg.4297
Escherichia coli 2362-75
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAN
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DQQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
T
K
V
SW
fig|656417.3.peg.3853
Escherichia coli M605
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAN
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
D
M
N
V
EFG
N
A
K
Q
GG
FE
A
K
V
SW
fig|405955.13.peg.3443
Escherichia coli APEC O1
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
N
I
D
VRL
TLNAN
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
D
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|405955.9.peg.2858
Escherichia coli APEC O1
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
N
I
D
VRL
TLNAN
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
D
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|714962.3.peg.3483
Escherichia coli IHE3034
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
N
I
D
VRL
TLNAN
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
D
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|585035.6.peg.3344
Escherichia coli S88
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
N
I
D
VRL
TLNAN
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
D
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|869729.3.peg.258
Escherichia coli UM146
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
N
I
D
VRL
TLNAN
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
D
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|364106.7.peg.3418
Escherichia coli UTI89
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
N
I
D
VRL
TLNAN
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
D
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|364106.8.peg.3419
Escherichia coli UTI89
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
N
I
D
VRL
TLNAN
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
D
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|753642.3.peg.4949
Escherichia coli NC101
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLKAN
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
D
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|656440.3.peg.3252
Escherichia coli TA206
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLKAN
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
D
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|525281.3.peg.3544
Escherichia coli 83972
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
T
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLKAN
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
DFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|655817.3.peg.3588
Escherichia coli ABU 83972
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
T
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLKAN
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
DFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|199310.1.peg.3679
Escherichia coli CFT073
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
T
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLKAN
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
DFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|199310.4.peg.3544
Escherichia coli CFT073
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
T
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLKAN
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
DFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|749546.3.peg.1910
Escherichia coli MS 185-1
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
T
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLKAN
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
DFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|749528.3.peg.500
Escherichia coli MS 45-1
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
T
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLKAN
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
DFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|685038.3.peg.3068
Escherichia coli O83:H1 str. NRG 857C
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
T
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLKAN
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
DFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|749533.3.peg.3616
Escherichia coli MS 84-1
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
R
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
G
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNVQ
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|585397.7.peg.3678
Escherichia coli ED1a
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
T
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
I
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLKAN
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
DFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|585397.9.peg.3676
Escherichia coli ED1a
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
T
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
I
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLKAN
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
DFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|749550.3.peg.4075
Escherichia coli MS 200-1
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
T
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
N
I
D
VRL
TLNAN
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
D
M
N
V
EFG
N
A
E
Q
GG
FE
A
K
V
SW
fig|216593.1.peg.5122
Escherichia coli E2348/69
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAN
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AR
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DQQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
T
K
V
SW
fig|574521.7.peg.3381
Escherichia coli O127:H6 str. E2348/69
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAN
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AR
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
A
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DQQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLNAH
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
G
M
N
V
EFG
N
A
E
Q
GG
FE
T
K
V
SW
fig|340197.3.peg.2633
Escherichia coli F11
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
T
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLKAN
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
D
M
N
V
EFG
N
A
K
Q
GG
FE
A
K
V
SW
fig|340197.5.peg.2759
Escherichia coli F11
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
T
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLKAN
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
D
M
N
V
EFG
N
A
K
Q
GG
FE
A
K
V
SW
fig|431946.3.peg.2988
Escherichia coli SE15
MKFTQR
L
SLR
V
RL
TLI
FL
IL
A
SVT
W
-
LL
SS
FVA
W
K
QT
T
DN
VD
----
E
L
F
D
TQ
L
M
L
F
A
KR
L
S
T
L
DLN
E
INAA
D
----
RM
AQT
P
N
K
L
K
H
-------
G
HVD
D
DA
L
T
F
A
I
FTH
D
GR-M
VL
N
D
GD
N
---
G
E
D
IPYS
Y
Q
R
EGFAD
G
QL
V
GED
D
P
W
R
FVW
M
T
-
-
--
-
-------------------------
S
P
--
DG
K
Y
R
IV
-
--
-
VG
QEWEY
REDM
A
L
A
I
V
---AG
Q
L
I
P
W
LV
A
--
L
P
I
M
L
I
I
---
M
MV
L
L
--
G
---
R
E
LA
P
L
NKL
A
LALR
M
RD
P
DSEK
PL
NAT
G
V
P
SE
V
R
P
L
VE
S
LNQ
L
FARTH
T
MMVR
E
R
R
FTSDA
AHELRSPL
T
AL
K
VQT
E
----------
VA
QL
SD
D
--
DPQ
AR
K
K
AL
L
Q
LH
SG
I
DRATR
L
VDQ
LLTL
S
RLD
S
L
D
N
L
Q
D
V
A
E
IP
L
ED
LL
QSS
V
M
DI
Y
------
H
TAQ
Q
A
K
I
D
VRL
TLKAN
G
IKR
T
G
Q
P
L
LL
SLL
V
R
NLLDNA
V
RY
S
P
QG
S
V
V
DV
T
L
NA
D
----
N
F
IV
R
D
N
GPG
V
T
PEAL
A
RI
G
ERFYR
P
P
---
GQ
T
A
T
GSGLGL
S
IV
QR
IA
K
L
H
D
M
N
V
EFG
N
A
K
Q
GG
FE
A
K
V
SW
fig|6666666.5357.peg.3582
Escherichia coli TY-2482 (1-456/466)
MRF
K
ISL
TT
RL
SLI
F
SA
V
M
LTV
W
-
W
L
SS
F
I
L
I
S
TL
N
GY
F
D
NQDR
D
F
L
T
GK
L
Q
L
T
E
EF
L
K
T
-
---
-
----
-
----
--
---
-
---
-
-
-------
-
---
-
--
-
-
-
E
T
FRN
K
TDIK
S
L
S
E
KI
N
D
A
MV
G
HNGLF
I
S
I
KNMEN
E
KI
V
ELY
A
K
N
S
V
V
P
A
I
L
L
NK
S
G
DILDYMIQ
T
EE
N
NTVYR
S
ISRR
VA
V
TPEQ
G
K
S
K
HV
-
II
T
V
A
-----
TDTG
Y
H
TLF
MDKLS
T
W
L
F
W
FN
I
GL
V
F
I
SV
F
L
G--
-
--
WL
TT
R
IGL
K
P
L
R
E
M
TSL
A
SSMT
V
HS
L
DQR-
-
L
NPD
LA
P
P
E
I
S
E
T
MQ
E
F
N
N
M
FDRLE
G
AFRK
L
S
D
FSSDI
AHELR
T
P
V
S
N
L
M
MQT
Q
----------
F
A
LA
K
E
R
--
DVS
HY
R
E
I
L
F
ANL
EE
L
KRLSR
M
TSD
M
L
F
L
A
R
S
E
HGLL
R
L
D
K
H
D
VD
L
AA
E
L
N-E
L
R
E
L
F
------
-
-
EP
L
AD
E
T
G
K
T
ITVEG
E
GVV
A
G
D
S
D
M
L
RRA
F
S
NLL
S
NAI
K
Y
S
P
DN
T
C
T
AI
H
L
ER
D
SDCV
N
VMI
T
N
T
M
S
G
Q
V
P
A
N
L
E
R
L
F
D
RFYR
A
D
SSR
FY
N
T
E
G
A
GLGL
S
I
T
RS
I
I
H
A
H
GG
E
L
---
S
A
E
Q
Q
G
RE
fig|585055.6.peg.3933
Escherichia coli 55989 (1-456/466)
MRF
K
ISL
TT
RL
SLI
F
SA
V
M
LTV
W
-
W
L
SS
F
I
L
I
S
TL
N
GY
F
D
NQDR
D
F
L
T
GK
L
Q
L
T
E
EF
L
K
T
-
---
-
----
-
----
--
---
-
---
-
-
-------
-
---
-
--
-
-
-
E
T
FRN
K
TDIK
S
L
S
E
KI
N
D
A
MV
G
HNGLF
I
S
I
KNMEN
E
KI
V
ELY
A
K
N
S
V
V
P
A
I
L
L
NK
S
G
DILDYMIQ
T
EE
N
NTVYR
S
ISRR
VA
V
TPEQ
G
K
S
K
HV
-
II
T
V
A
-----
TDTG
Y
H
TLF
MDKLS
T
W
L
F
W
FN
I
GL
V
F
I
SV
F
L
G--
-
--
WL
TT
R
IGL
K
P
L
R
E
M
TSL
A
SSMT
V
HS
L
DQR-
-
L
NPD
LA
P
P
E
I
S
E
T
MQ
E
F
N
N
M
FDRLE
G
AFRK
L
S
D
FSSDI
AHELR
T
P
V
S
N
L
M
MQT
Q
----------
F
A
LA
K
E
R
--
DVS
HY
R
E
I
L
F
ANL
EE
L
KRLSR
M
TSD
M
L
F
L
A
R
S
E
HGLL
R
L
D
K
H
D
VD
L
AA
E
L
N-E
L
R
E
L
F
------
-
-
EP
L
AD
E
T
G
K
T
ITVEG
E
GVV
A
G
D
S
D
M
L
RRA
F
S
NLL
S
NAI
K
Y
S
P
DN
T
C
T
AI
H
L
ER
D
SDCV
N
VMI
T
N
T
M
S
G
Q
V
P
A
N
L
E
R
L
F
D
RFYR
A
D
SSR
FY
N
T
E
G
A
GLGL
S
I
T
RS
I
I
H
A
H
GG
E
L
---
S
A
E
Q
Q
G
RE
fig|585055.8.peg.3935
Escherichia coli 55989 (1-456/466)
MRF
K
ISL
TT
RL
SLI
F
SA
V
M
LTV
W
-
W
L
SS
F
I
L
I
S
TL
N
GY
F
D
NQDR
D
F
L
T
GK
L
Q
L
T
E
EF
L
K
T
-
---
-
----
-
----
--
---
-
---
-
-
-------
-
---
-
--
-
-
-
E
T
FRN
K
TDIK
S
L
S
E
KI
N
D
A
MV
G
HNGLF
I
S
I
KNMEN
E
KI
V
ELY
A
K
N
S
V
V
P
A
I
L
L
NK
S
G
DILDYMIQ
T
EE
N
NTVYR
S
ISRR
VA
V
TPEQ
G
K
S
K
HV
-
II
T
V
A
-----
TDTG
Y
H
TLF
MDKLS
T
W
L
F
W
FN
I
GL
V
F
I
SV
F
L
G--
-
--
WL
TT
R
IGL
K
P
L
R
E
M
TSL
A
SSMT
V
HS
L
DQR-
-
L
NPD
LA
P
P
E
I
S
E
T
MQ
E
F
N
N
M
FDRLE
G
AFRK
L
S
D
FSSDI
AHELR
T
P
V
S
N
L
M
MQT
Q
----------
F
A
LA
K
E
R
--
DVS
HY
R
E
I
L
F
ANL
EE
L
KRLSR
M
TSD
M
L
F
L
A
R
S
E
HGLL
R
L
D
K
H
D
VD
L
AA
E
L
N-E
L
R
E
L
F
------
-
-
EP
L
AD
E
T
G
K
T
ITVEG
E
GVV
A
G
D
S
D
M
L
RRA
F
S
NLL
S
NAI
K
Y
S
P
DN
T
C
T
AI
H
L
ER
D
SDCV
N
VMI
T
N
T
M
S
G
Q
V
P
A
N
L
E
R
L
F
D
RFYR
A
D
SSR
FY
N
T
E
G
A
GLGL
S
I
T
RS
I
I
H
A
H
GG
E
L
---
S
A
E
Q
Q
G
RE
fig|405955.13.peg.5327
Escherichia coli APEC O1 (1-456/466)
MRF
K
ISL
TT
RL
SLI
F
SA
V
M
LTV
W
-
W
L
SS
F
I
L
I
S
TL
N
GY
F
D
NQDR
D
F
L
T
GK
L
Q
L
T
E
EF
L
K
T
-
---
-
----
-
----
--
---
-
---
-
-
-------
-
---
-
--
-
-
-
E
T
FRN
K
TDIK
S
L
S
E
KI
N
D
A
MV
G
HNGLF
I
S
I
KNMEN
E
KI
V
ELY
A
K
N
S
V
V
P
A
V
L
L
NK
S
G
DILDYMIQ
T
EE
N
NTVYR
S
ISRR
VA
V
TPEQ
G
K
S
K
HV
-
II
T
V
A
-----
TDTG
Y
H
TLF
MDKLS
T
W
L
F
W
FN
I
GL
V
F
I
SV
F
L
G--
-
--
WL
TT
R
IGL
K
P
L
R
E
M
TSL
A
SSMT
V
HS
L
DQR-
-
L
NPD
LA
P
P
E
I
S
E
T
MQ
E
F
N
N
M
FDRLE
G
AFRK
L
S
D
FSSDI
AHELR
T
P
V
S
N
L
M
MQT
Q
----------
F
A
LA
K
E
R
--
DVS
HY
R
E
I
L
F
ANL
EE
L
KRLSR
M
TSD
M
L
F
L
A
R
S
E
HGLL
R
L
D
K
H
D
VD
L
AA
E
L
N-E
L
R
E
L
F
------
-
-
EP
L
AD
E
T
G
K
T
ITVEG
E
GVV
A
G
D
S
D
M
L
RRA
F
S
NLL
S
NAI
K
Y
S
P
DN
T
C
T
AI
H
L
ER
D
SDCV
N
VMI
T
N
T
M
S
G
Q
V
P
A
N
L
E
R
L
F
D
RFYR
A
D
SSR
FY
N
T
E
G
A
GLGL
S
I
T
RS
I
I
H
A
H
GG
E
L
---
S
A
E
Q
Q
G
RE
fig|405955.9.peg.4443
Escherichia coli APEC O1 (1-456/466)
MRF
K
ISL
TT
RL
SLI
F
SA
V
M
LTV
W
-
W
L
SS
F
I
L
I
S
TL
N
GY
F
D
NQDR
D
F
L
T
GK
L
Q
L
T
E
EF
L
K
T
-
---
-
----
-
----
--
---
-
---
-
-
-------
-
---
-
--
-
-
-
E
T
FRN
K
TDIK
S
L
S
E
KI
N
D
A
MV
G
HNGLF
I
S
I
KNMEN
E
KI
V
ELY
A
K
N
S
V
V
P
A
V
L
L
NK
S
G
DILDYMIQ
T
EE
N
NTVYR
S
ISRR
VA
V
TPEQ
G
K
S
K
HV
-
II
T
V
A
-----
TDTG
Y
H
TLF
MDKLS
T
W
L
F
W
FN
I
GL
V
F
I
SV
F
L
G--
-
--
WL
TT
R
IGL
K
P
L
R
E
M
TSL
A
SSMT
V
HS
L
DQR-
-
L
NPD
LA
P
P
E
I
S
E
T
MQ
E
F
N
N
M
FDRLE
G
AFRK
L
S
D
FSSDI
AHELR
T
P
V
S
N
L
M
MQT
Q
----------
F
A
LA
K
E
R
--
DVS
HY
R
E
I
L
F
ANL
EE
L
KRLSR
M
TSD
M
L
F
L
A
R
S
E
HGLL
R
L
D
K
H
D
VD
L
AA
E
L
N-E
L
R
E
L
F
------
-
-
EP
L
AD
E
T
G
K
T
ITVEG
E
GVV
A
G
D
S
D
M
L
RRA
F
S
NLL
S
NAI
K
Y
S
P
DN
T
C
T
AI
H
L
ER
D
SDCV
N
VMI
T
N
T
M
S
G
Q
V
P
A
N
L
E
R
L
F
D
RFYR
A
D
SSR
FY
N
T
E
G
A
GLGL
S
I
T
RS
I
I
H
A
H
GG
E
L
---
S
A
E
Q
Q
G
RE
fig|481805.3.peg.3668
Escherichia coli ATCC 8739 (1-456/466)
MRF
K
ISL
TT
RL
SLI
F
SA
V
M
LTV
W
-
W
L
SS
F
I
L
I
S
TL
N
GY
F
D
NQDR
D
F
L
T
GK
L
Q
L
T
E
EF
L
K
T
-
---
-
----
-
----
--
---
-
---
-
-
-------
-
---
-
--
-
-
-
E
T
FRN
K
TDIK
S
L
S
E
KI
N
D
A
MV
G
HNGLF
I
S
I
KNMEN
E
KI
V
ELY
A
K
N
S
V
V
P
A
V
L
L
NK
S
G
DILDYMIQ
T
EE
N
NTVYR
S
ISRR
VA
V
TPEQ
G
K
S
K
HV
-
II
T
V
A
-----
TDTG
Y
H
TLF
MDKLS
T
W
L
F
W
FN
I
GL
V
F
I
SV
F
L
G--
-
--
WL
TT
R
IGL
K
P
L
R
E
M
TSL
A
SSMT
V
HS
L
DQR-
-
L
NPD
LA
P
P
E
I
S
E
T
MQ
E
F
N
N
M
FDRLE
G
AFRK
L
S
D
FSSDI
AHELR
T
P
V
S
N
L
M
MQT
Q
----------
F
A
LA
K
E
R
--
DVS
HY
R
E
I
L
F
ANL
EE
L
KRLSR
M
TSD
M
L
F
L
A
R
S
E
HGLL
R
L
D
K
H
D
VD
L
AA
E
L
N-E
L
R
E
L
F
------
-
-
EP
L
AD
E
T
G
K
T
ITVEG
E
GVV
A
G
D
S
D
M
L
RRA
F
S
NLL
S
NAI
K
Y
S
P
DN
T
C
T
AI
H
L
ER
D
SDCV
N
VMI
T
N
T
M
S
G
Q
V
P
A
N
L
E
R
L
F
D
RFYR
A
D
SSR
FY
N
T
E
G
A
GLGL
S
I
T
RS
I
I
H
A
H
GG
E
L
---
S
A
E
Q
Q
G
RE
fig|481805.6.peg.3645
Escherichia coli ATCC 8739 (1-456/466)
MRF
K
ISL
TT
RL
SLI
F
SA
V
M
LTV
W
-
W
L
SS
F
I
L
I
S
TL
N
GY
F
D
NQDR
D
F
L
T
GK
L
Q
L
T
E
EF
L
K
T
-
---
-
----
-
----
--
---
-
---
-
-
-------
-
---
-
--
-
-
-
E
T
FRN
K
TDIK
S
L
S
E
KI
N
D
A
MV
G
HNGLF
I
S
I
KNMEN
E
KI
V
ELY
A
K
N
S
V
V
P
A
V
L
L
NK
S
G
DILDYMIQ
T
EE
N
NTVYR
S
ISRR
VA
V
TPEQ
G
K
S
K
HV
-
II
T
V
A
-----
TDTG
Y
H
TLF
MDKLS
T
W
L
F
W
FN
I
GL
V
F
I
SV
F
L
G--
-
--
WL
TT
R
IGL
K
P
L
R
E
M
TSL
A
SSMT
V
HS
L
DQR-
-
L
NPD
LA
P
P
E
I
S
E
T
MQ
E
F
N
N
M
FDRLE
G
AFRK
L
S
D
FSSDI
AHELR
T
P
V
S
N
L
M
MQT
Q
----------
F
A
LA
K
E
R
--
DVS
HY
R
E
I
L
F
ANL
EE
L
KRLSR
M
TSD
M
L
F
L
A
R
S
E
HGLL
R
L
D
K
H
D
VD
L
AA
E
L
N-E
L
R
E
L
F
------
-
-
EP
L
AD
E
T
G
K
T
ITVEG
E
GVV
A
G
D
S
D
M
L
RRA
F
S
NLL
S
NAI
K
Y
S
P
DN
T
C
T
AI
H
L
ER
D
SDCV
N
VMI
T
N
T
M
S
G
Q
V
P
A
N
L
E
R
L
F
D
RFYR
A
D
SSR
FY
N
T
E
G
A
GLGL
S
I
T
RS
I
I
H
A
H
GG
E
L
---
S
A
E
Q
Q
G
RE
fig|316401.4.peg.266
Escherichia coli ETEC H10407 (1-456/466)
MRF
K
ISL
TT
RL
SLI
F
SA
V
M
LTV
W
-
W
L
SS
F
I
L
I
S
TL
N
GY
F
D
NQDR
D
F
L
T
GK
L
Q
L
T
E
EF
L
K
T
-
---
-
----
-
----
--
---
-
---
-
-
-------
-
---
-
--
-
-
-
E
T
FRN
K
TDIK
S
L
S
E
KI
N
D
A
MV
G
HNGLF
I
S
I
KNMEN
E
KI
V
ELY
A
K
N
S
V
V
P
A
V
L
L
NK
S
G
DILDYMIQ
T
EE
N
NTVYR
S
ISRR
VA
V
TPEQ
G
K
S
K
HV
-
II
T
V
A
-----
TDTG
Y
H
TLF
MDKLS
T
W
L
F
W
FN
I
GL
V
F
I
SV
F
L
G--
-
--
WL
TT
R
IGL
K
P
L
R
E
M
TSL
A
SSMT
V
HS
L
DQR-
-
L
NPD
LA
P
P
E
I
S
E
T
MQ
E
F
N
N
M
FDRLE
G
AFRK
L
S
D
FSSDI
AHELR
T
P
V
S
N
L
M
MQT
Q
----------
F
A
LA
K
E
R
--
DVS
HY
R
E
I
L
F
ANL
EE
L
KRLSR
M
TSD
M
L
F
L
A
R
S
E
HGLL
R
L
D
K
H
D
VD
L
AA
E
L
N-E
L
R
E
L
F
------
-
-
EP
L
AD
E
T
G
K
T
ITVEG
E
GVV
A
G
D
S
D
M
L
RRA
F
S
NLL
S
NAI
K
Y
S
P
DN
T
C
T
AI
H
L
ER
D
SDCV
N
VMI
T
N
T
M
S
G
Q
V
P
A
N
L
E
R
L
F
D
RFYR
A
D
SSR
FY
N
T
E
G
A
GLGL
S
I
T
RS
I
I
H
A
H
GG
E
L
---
S
A
E
Q
Q
G
RE
fig|749537.3.peg.111
Escherichia coli MS 115-1 (1-456/466)
MRF
K
ISL
TT
RL
SLI
F
SA
V
M
LTV
W
-
W
L
SS
F
I
L
I
S
TL
N
GY
F
D
NQDR
D
F
L
T
GK
L
Q
L
T
E
EF
L
K
T
-
---
-
----
-
----
--
---
-
---
-
-
-------
-
---
-
--
-
-
-
E
T
FRN
K
TDIK
S
L
S
E
KI
N
D
A
MV
G
HNGLF
I
S
I
KNMEN
E
KI
V
ELY
A
K
N
S
V
V
P
A
V
L
L
NK
S
G
DILDYMIQ
T
EE
N
NTVYR
S
ISRR
VA
V
TPEQ
G
K
S
K
HV
-
II
T
V
A
-----
TDTG
Y
H
TLF
MDKLS
T
W
L
F
W
FN
I
GL
V
F
I
SV
F
L
G--
-
--
WL
TT
R
IGL
K
P
L
R
E
M
TSL
A
SSMT
V
HS
L
DQR-
-
L
NPD
LA
P
P
E
I
S
E
T
MQ
E
F
N
N
M
FDRLE
G
AFRK
L
S
D
FSSDI
AHELR
T
P
V
S
N
L
M
MQT
Q
----------
F
A
LA
K
E
R
--
DVS
HY
R
E
I
L
F
ANL
EE
L
KRLSR
M
TSD
M
L
F
L
A
R
S
E
HGLL
R
L
D
K
H
D
VD
L
AA
E
L
N-E
L
R
E
L
F
------
-
-
EP
L
AD
E
T
G
K
T
ITVEG
E
GVV
A
G
D
S
D
M
L
RRA
F
S
NLL
S
NAI
K
Y
S
P
DN
T
C
T
AI
H
L
ER
D
SDCV
N
VMI
T
N
T
M
S
G
Q
V
P
A
N
L
E
R
L
F
D
RFYR
A
D
SSR
FY
N
T
E
G
A
GLGL
S
I
T
RS
I
I
H
A
H
GG
E
L
---
S
A
E
Q
Q
G
RE
fig|358709.5.peg.1124
Escherichia coli 101-1 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNKA
TLIV
E
D
D
G
S
GI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
G
R
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCG
T
S
E
L
GG
AR
F
S
F
SW
fig|670888.3.peg.99
Escherichia coli 1827-70 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNKA
TLIV
E
D
D
G
S
GI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
G
R
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCG
T
S
E
L
GG
AR
F
S
F
SW
fig|344610.3.peg.3176
Escherichia coli 53638 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNKA
TLIV
E
D
D
G
S
GI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
G
R
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCG
T
S
E
L
GG
AR
F
S
F
SW
fig|344610.7.peg.5257
Escherichia coli 53638 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNKA
TLIV
E
D
D
G
S
GI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
G
R
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCG
T
S
E
L
GG
AR
F
S
F
SW
fig|481805.3.peg.2178
Escherichia coli ATCC 8739 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNKA
TLIV
E
D
D
G
S
GI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
G
R
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCG
T
S
E
L
GG
AR
F
S
F
SW
fig|481805.6.peg.2172
Escherichia coli ATCC 8739 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNKA
TLIV
E
D
D
G
S
GI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
G
R
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCG
T
S
E
L
GG
AR
F
S
F
SW
fig|413997.3.peg.1653
Escherichia coli B str. REL606 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNKA
TLIV
E
D
D
G
S
GI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
G
R
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCG
T
S
E
L
GG
AR
F
S
F
SW
fig|511693.5.peg.1678
Escherichia coli BL21 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNKA
TLIV
E
D
D
G
S
GI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
G
R
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCG
T
S
E
L
GG
AR
F
S
F
SW
fig|469008.4.peg.2096
Escherichia coli BL21(DE3) (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNKA
TLIV
E
D
D
G
S
GI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
G
R
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCG
T
S
E
L
GG
AR
F
S
F
SW
fig|331112.3.peg.1585
Escherichia coli HS (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNKA
TLIV
E
D
D
G
S
GI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
G
R
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCG
T
S
E
L
GG
AR
F
S
F
SW
fig|331112.6.peg.1652
Escherichia coli HS (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNKA
TLIV
E
D
D
G
S
GI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
G
R
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCG
T
S
E
L
GG
AR
F
S
F
SW
fig|749547.3.peg.3553
Escherichia coli MS 187-1 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNKA
TLIV
E
D
D
G
S
GI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
G
R
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCG
T
S
E
L
GG
AR
F
S
F
SW
fig|637912.3.peg.1549
Escherichia coli OP50 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNKA
TLIV
E
D
D
G
S
GI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
G
R
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCG
T
S
E
L
GG
AR
F
S
F
SW
fig|362663.8.peg.1568
Escherichia coli 536 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
SERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|362663.9.peg.1572
Escherichia coli 536 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
SERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|685038.3.peg.1626
Escherichia coli O83:H1 str. NRG 857C (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
SERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|749550.3.peg.3437
Escherichia coli MS 200-1 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
L
H
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
SERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|656437.3.peg.1820
Escherichia coli TA143 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
SERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
M
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|753642.3.peg.1553
Escherichia coli NC101 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
SERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|405955.13.peg.1692
Escherichia coli APEC O1 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
SERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|405955.9.peg.1377
Escherichia coli APEC O1 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
SERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|199310.1.peg.1939
Escherichia coli CFT073 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
SERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|199310.4.peg.1868
Escherichia coli CFT073 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
SERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|585397.7.peg.1827
Escherichia coli ED1a (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
SERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|585397.9.peg.1822
Escherichia coli ED1a (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
SERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|714962.3.peg.1760
Escherichia coli IHE3034 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
SERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|656417.3.peg.2102
Escherichia coli M605 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
SERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|749528.3.peg.3835
Escherichia coli MS 45-1 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
SERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|585035.6.peg.1647
Escherichia coli S88 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
SERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|431946.3.peg.1528
Escherichia coli SE15 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
SERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|364106.7.peg.1839
Escherichia coli UTI89 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
SERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|364106.8.peg.1842
Escherichia coli UTI89 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
SERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|562.376.peg.2947
Escherichia coli WV_060327 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
SERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|439855.10.peg.1749
Escherichia coli SMS-3-5 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|83334.1.peg.2344
Escherichia coli O157:H7 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
F
Q
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|386585.9.peg.2425
Escherichia coli O157:H7 str. Sakai (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
F
Q
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|550677.3.peg.2992
Escherichia coli B354 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
M
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|562.371.peg.4454
Escherichia coli 1044A (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|562.373.peg.5357
Escherichia coli 1125A (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|562.372.peg.4688
Escherichia coli 1212A (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|562.374.peg.4424
Escherichia coli 536A (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|155864.1.peg.2352
Escherichia coli O157:H7 EDL933 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|155864.8.peg.2192
Escherichia coli O157:H7 EDL933 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|444454.5.peg.5593
Escherichia coli O157:H7 str. EC4024 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|444449.5.peg.540
Escherichia coli O157:H7 str. EC4042 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|444448.5.peg.4848
Escherichia coli O157:H7 str. EC4045 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|444453.5.peg.4712
Escherichia coli O157:H7 str. EC4076 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|444452.5.peg.3514
Escherichia coli O157:H7 str. EC4113 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|444450.8.peg.2359
Escherichia coli O157:H7 str. EC4115 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|444451.5.peg.3379
Escherichia coli O157:H7 str. EC4196 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|444447.5.peg.5140
Escherichia coli O157:H7 str. EC4206 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|478005.5.peg.4815
Escherichia coli O157:H7 str. EC4486 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|478006.5.peg.4065
Escherichia coli O157:H7 str. EC4501 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|478007.5.peg.3524
Escherichia coli O157:H7 str. EC508 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|478008.5.peg.4519
Escherichia coli O157:H7 str. EC869 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|637388.3.peg.5034
Escherichia coli O157:H7 str. FRIK2000 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|570506.3.peg.4198
Escherichia coli O157:H7 str. FRIK966 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|544404.4.peg.2222
Escherichia coli O157:H7 str. TW14359 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|502346.5.peg.5090
Escherichia coli O157:H7 str. TW14588 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|701177.3.peg.2000
Escherichia coli O55:H7 str. CB9615 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|550676.3.peg.1913
Escherichia coli B185 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDAI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|595496.3.peg.1569
Escherichia coli BW2952 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|536056.3.peg.2145
Escherichia coli DH1 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|316401.4.peg.1892
Escherichia coli ETEC H10407 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|656414.3.peg.1916
Escherichia coli H736 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|83333.1.peg.1595
Escherichia coli K12 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|749538.3.peg.4158
Escherichia coli MS 116-1 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|749540.3.peg.4249
Escherichia coli MS 146-1 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|749548.3.peg.4756
Escherichia coli MS 196-1 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|316407.3.peg.1566
Escherichia coli W3110 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|316385.5.peg.1721
Escherichia coli str. K-12 substr. DH10B (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|316385.7.peg.1766
Escherichia coli str. K-12 substr. DH10B (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|511145.12.peg.1680
Escherichia coli str. K-12 substr. MG1655 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|511145.6.peg.1664
Escherichia coli str. K-12 substr. MG1655 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|216592.1.peg.2214
Escherichia coli 042 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|216592.3.peg.1848
Escherichia coli 042 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|670897.3.peg.2314
Escherichia coli 2362-75 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|216593.1.peg.379
Escherichia coli E2348/69 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|656379.3.peg.2077
Escherichia coli FVEC1302 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|656380.3.peg.3042
Escherichia coli FVEC1412 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|585057.4.peg.1515
Escherichia coli IAI39 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|585057.6.peg.1514
Escherichia coli IAI39 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|749549.3.peg.5271
Escherichia coli MS 198-1 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|749531.3.peg.4828
Escherichia coli MS 69-1 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|574521.7.peg.1730
Escherichia coli O127:H6 str. E2348/69 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|585056.7.peg.2083
Escherichia coli UMN026 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|656419.3.peg.2315
Escherichia coli M718 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
G
HYA
A
L
D
I
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|749527.3.peg.4278
Escherichia coli MS 21-1 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
D
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|550672.3.peg.2449
Escherichia coli B088 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|340184.3.peg.993
Escherichia coli B7A (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|340184.6.peg.1028
Escherichia coli B7A (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|340186.3.peg.3436
Escherichia coli E110019 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|340186.5.peg.3589
Escherichia coli E110019 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|562.375.peg.1711
Escherichia coli EC4100B (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|595495.4.peg.2830
Escherichia coli KO11 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|679205.4.peg.1642
Escherichia coli MS 124-1 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|749533.3.peg.4916
Escherichia coli MS 84-1 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|585396.4.peg.2159
Escherichia coli O111:H- str. 11128 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|573235.3.peg.2373
Escherichia coli O26:H11 str. 11368 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|409438.11.peg.1877
Escherichia coli SE11 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|566546.3.peg.1043
Escherichia coli W (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|566546.4.peg.1762
Escherichia coli W (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|6666666.5357.peg.3540
Escherichia coli TY-2482 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|585055.6.peg.1804
Escherichia coli 55989 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|585055.8.peg.1808
Escherichia coli 55989 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|656408.3.peg.1750
Escherichia coli H591 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|585034.4.peg.1643
Escherichia coli IAI1 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|585034.5.peg.1638
Escherichia coli IAI1 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|679207.4.peg.4277
Escherichia coli MS 107-1 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|749537.3.peg.2376
Escherichia coli MS 115-1 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|679206.4.peg.1294
Escherichia coli MS 119-7 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|331111.12.peg.2104
Escherichia coli E24377A (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
T
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|331111.3.peg.4246
Escherichia coli E24377A (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
T
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLVQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|344601.3.peg.354
Escherichia coli B171 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
T
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|344601.5.peg.351
Escherichia coli B171 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
T
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|340185.3.peg.3295
Escherichia coli E22 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
T
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|340185.4.peg.3471
Escherichia coli E22 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
T
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|585395.4.peg.1832
Escherichia coli O103:H2 str. 12009 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
T
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|656393.3.peg.2399
Escherichia coli H299 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
V
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|749546.3.peg.4160
Escherichia coli MS 185-1 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
SERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
D
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|749545.3.peg.5129
Escherichia coli MS 182-1 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
Y
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|749532.3.peg.3794
Escherichia coli MS 78-1 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GI
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
Y
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLAQ
G
HYA
A
L
D
M
R
L
M
ERV
L
D
NLL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|656444.3.peg.2504
Escherichia coli TA280 (12-421/433)
L
FVC
FL
VM
S
LLV
G
-
L
V
YK
F
T
A
E
R
AG
K
QS
L
D
----
D
L
M
N
SS
L
Y
L
M
R
SE
L
R
E
I
PPH
D
----
-
----
-W
GK
T
L
K
E
M
-
-
-------
-
---
D
LN
L
S
F
D
L
RVE
P
LSKY
H
L
D
D
--
-
---
-
-
-
----
I
S
M
HRLRG
G
EI
V
ALD
D
Q
Y
T
F
LQ
R
I
P
R
SH
Y
-------------------------
-
-
--
--
-
-
-
--
-
VL
A
VG
-----
----
-
P
V
P
Y
LYYLH
Q
M
R
L
L
DI
A
LI
A
F
IA
I
S
L
AFP
V
FI
W
M
--
R
PHWQ
D
M
L
K
L
EAA
A
QRFG
D
GH
L
NERI
HF
DE-
-
-
G
S
S
F
E
R
L
GV
A
F
NQM
ADNIN
A
LIAS
K
K
Q
LIDGI
AHELR
T
PL
V
R
LR
YRL
E
----------
--
-M
SDN
--
LSA
A
E
S
QAL
N
R
--
-D
I
SQLEA
L
IEE
LLT
Y
A
RLDR
P
Q
N
E
L
H
L
S
E
PD
L
PL
W
L
STH
L
ADI
Q
------
-
-
A
V
T
P
DK
T
VR
I
KTLMQ
D
HYA
A
L
D
M
R
L
M
ERV
L
D
I
LL
N
NA
L
RY
C
-
-H
S
T
V
ET
SL
LL
S
GNRA
TLIV
E
D
D
GPGI
A
PE
NR
E
H
IFE
P
F
V
RL
D
PSR
DR
S
T
G
G
C
GLGLAIV
HS
IA
L
A
M
GG
T
V
NCD
T
S
E
L
GG
AR
F
S
F
SW
fig|550677.3.peg.379
Escherichia coli B354 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAC
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
EG
G
C
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
CE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|585397.7.peg.5245
Escherichia coli ED1a (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
INV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEYV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
ML
AS
L
fig|585397.9.peg.5246
Escherichia coli ED1a (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
INV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEYV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
ML
AS
L
fig|753642.3.peg.3647
Escherichia coli NC101 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
INV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEYV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
ML
AS
L
fig|685038.3.peg.4542
Escherichia coli O83:H1 str. NRG 857C (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
INV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEYV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
ML
AS
L
fig|550676.3.peg.4660
Escherichia coli B185 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
HEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|585057.4.peg.5083
Escherichia coli IAI39 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
INV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|585057.6.peg.5095
Escherichia coli IAI39 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
INV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|749532.3.peg.4278
Escherichia coli MS 78-1 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|656444.3.peg.313
Escherichia coli TA280 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
C
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|670897.3.peg.1810
Escherichia coli 2362-75 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
K
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|595496.3.peg.4493
Escherichia coli BW2952 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
K
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|536056.3.peg.3808
Escherichia coli DH1 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
P
PFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
K
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|216593.1.peg.3584
Escherichia coli E2348/69 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
K
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|83333.1.peg.4307
Escherichia coli K12 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
K
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|749527.3.peg.3983
Escherichia coli MS 21-1 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
K
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|749531.3.peg.3895
Escherichia coli MS 69-1 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
K
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|574521.7.peg.4809
Escherichia coli O127:H6 str. E2348/69 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
K
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|155864.1.peg.5320
Escherichia coli O157:H7 EDL933 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IXRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAX
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
KS
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|155864.8.peg.5317
Escherichia coli O157:H7 EDL933 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IXRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAX
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
KS
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|316407.3.peg.4223
Escherichia coli W3110 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
K
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|316385.5.peg.4506
Escherichia coli str. K-12 substr. DH10B (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
K
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|316385.7.peg.4605
Escherichia coli str. K-12 substr. DH10B (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
K
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|511145.12.peg.4548
Escherichia coli str. K-12 substr. MG1655 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
K
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|511145.6.peg.4525
Escherichia coli str. K-12 substr. MG1655 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
K
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|362663.8.peg.4755
Escherichia coli 536 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
INV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEYV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|362663.9.peg.4770
Escherichia coli 536 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
INV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEYV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|340197.3.peg.3258
Escherichia coli F11 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
INV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEYV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|340197.5.peg.3410
Escherichia coli F11 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
INV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEYV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|656417.3.peg.51
Escherichia coli M605 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
INV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEYV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|749550.3.peg.2451
Escherichia coli MS 200-1 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
INV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEYV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|525281.3.peg.1276
Escherichia coli 83972 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
S
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEYV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|655817.3.peg.5249
Escherichia coli ABU 83972 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
S
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEYV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|405955.13.peg.5023
Escherichia coli APEC O1 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
S
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEYV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|405955.9.peg.4221
Escherichia coli APEC O1 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
S
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEYV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|199310.1.peg.5375
Escherichia coli CFT073 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
S
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEYV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|199310.4.peg.5139
Escherichia coli CFT073 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
S
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEYV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|714962.3.peg.4994
Escherichia coli IHE3034 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
S
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEYV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|749528.3.peg.2137
Escherichia coli MS 45-1 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
S
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEYV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|585035.6.peg.4982
Escherichia coli S88 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
S
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEYV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|869729.3.peg.4891
Escherichia coli UM146 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
S
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEYV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|364106.7.peg.5036
Escherichia coli UTI89 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
S
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEYV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|364106.8.peg.5038
Escherichia coli UTI89 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
S
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEYV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|562.376.peg.938
Escherichia coli WV_060327 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
S
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEYV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|656437.3.peg.43
Escherichia coli TA143 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
V
R
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
K
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|340185.3.peg.4018
Escherichia coli E22 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGP
S
PEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|340185.4.peg.4243
Escherichia coli E22 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGP
S
PEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|656393.3.peg.609
Escherichia coli H299 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YIYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
K
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEYV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|562.371.peg.3925
Escherichia coli 1044A (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
KS
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|562.373.peg.2280
Escherichia coli 1125A (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
KS
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|562.372.peg.3131
Escherichia coli 1212A (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
KS
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|562.374.peg.2903
Escherichia coli 536A (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
KS
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|83334.1.peg.5337
Escherichia coli O157:H7 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
KS
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|444454.5.peg.4458
Escherichia coli O157:H7 str. EC4024 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
KS
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|444449.5.peg.3907
Escherichia coli O157:H7 str. EC4042 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
KS
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|444448.5.peg.2665
Escherichia coli O157:H7 str. EC4045 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
KS
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|444453.5.peg.3102
Escherichia coli O157:H7 str. EC4076 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
KS
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|444452.5.peg.3872
Escherichia coli O157:H7 str. EC4113 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
KS
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|444450.8.peg.5745
Escherichia coli O157:H7 str. EC4115 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
KS
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|444451.5.peg.4116
Escherichia coli O157:H7 str. EC4196 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
KS
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|444447.5.peg.2830
Escherichia coli O157:H7 str. EC4206 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
KS
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|478006.5.peg.3185
Escherichia coli O157:H7 str. EC4501 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
KS
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|478007.5.peg.814
Escherichia coli O157:H7 str. EC508 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
KS
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|478008.5.peg.425
Escherichia coli O157:H7 str. EC869 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
KS
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|637388.3.peg.3834
Escherichia coli O157:H7 str. FRIK2000 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
KS
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|570506.3.peg.997
Escherichia coli O157:H7 str. FRIK966 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
KS
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|386585.9.peg.5605
Escherichia coli O157:H7 str. Sakai (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
KS
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|544404.4.peg.5554
Escherichia coli O157:H7 str. TW14359 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
KS
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|502346.5.peg.1267
Escherichia coli O157:H7 str. TW14588 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
KS
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|701177.3.peg.5276
Escherichia coli O55:H7 str. CB9615 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
D
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
KS
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|656440.3.peg.5044
Escherichia coli TA206 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEYV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
L
S
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLC
N
V
Q
E
GG
VL
AS
L
fig|656414.3.peg.108
Escherichia coli H736 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
N
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
A
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|1040638.4.peg.818
Escherichia coli O104:H4 str. LB226692 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|6666666.5357.peg.2035
Escherichia coli TY-2482 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|585055.6.peg.5068
Escherichia coli 55989 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|585055.8.peg.5073
Escherichia coli 55989 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|409438.11.peg.4865
Escherichia coli SE11 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|656443.3.peg.117
Escherichia coli TA271 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
TRP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|749546.3.peg.2293
Escherichia coli MS 185-1 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VYV
A
S
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
D
QEYV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|550672.3.peg.4269
Escherichia coli B088 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|344601.3.peg.3508
Escherichia coli B171 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|344601.5.peg.3667
Escherichia coli B171 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|340184.3.peg.2493
Escherichia coli B7A (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|340184.6.peg.2612
Escherichia coli B7A (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|331111.12.peg.5193
Escherichia coli E24377A (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|331111.3.peg.2570
Escherichia coli E24377A (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|656408.3.peg.4944
Escherichia coli H591 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|331112.3.peg.4339
Escherichia coli HS (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|331112.6.peg.4518
Escherichia coli HS (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|585034.4.peg.4494
Escherichia coli IAI1 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|585034.5.peg.4490
Escherichia coli IAI1 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|595495.4.peg.4380
Escherichia coli KO11 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|679207.4.peg.1030
Escherichia coli MS 107-1 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|679206.4.peg.4200
Escherichia coli MS 119-7 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|585395.4.peg.5523
Escherichia coli O103:H2 str. 12009 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|585396.4.peg.5492
Escherichia coli O111:H- str. 11128 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|566546.3.peg.3668
Escherichia coli W (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|566546.4.peg.4705
Escherichia coli W (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|679204.3.peg.2809
Escherichia coli MS 145-7 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
H
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|481805.3.peg.3930
Escherichia coli ATCC 8739 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
N
G
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
SAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
VVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|481805.6.peg.3911
Escherichia coli ATCC 8739 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
N
G
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
SAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
VVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|478004.5.peg.3517
Escherichia coli O157:H7 str. EC4401 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
E
I
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
KS
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|478005.5.peg.872
Escherichia coli O157:H7 str. EC4486 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
E
I
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
KS
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|749540.3.peg.3334
Escherichia coli MS 146-1 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
A
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
DQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|431946.3.peg.4520
Escherichia coli SE15 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
K
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
TL
S
A
EV
E
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|344610.3.peg.747
Escherichia coli 53638 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAI
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
VVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|344610.7.peg.1748
Escherichia coli 53638 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAI
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
VVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|316401.4.peg.5418
Escherichia coli ETEC H10407 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNP
T
DPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
VVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|216592.1.peg.4428
Escherichia coli 042 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
VVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|216592.3.peg.5093
Escherichia coli 042 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
VVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|358709.5.peg.4031
Escherichia coli 101-1 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
VVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|413997.3.peg.4520
Escherichia coli B str. REL606 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
VVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|511693.5.peg.4547
Escherichia coli BL21 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
VVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|469008.4.peg.3748
Escherichia coli BL21(DE3) (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
VVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|340186.3.peg.3814
Escherichia coli E110019 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
VVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|340186.5.peg.4005
Escherichia coli E110019 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
VVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|562.375.peg.2666
Escherichia coli EC4100B (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
VVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|656419.3.peg.147
Escherichia coli M718 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
VVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|749537.3.peg.1808
Escherichia coli MS 115-1 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
VVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|749538.3.peg.1016
Escherichia coli MS 116-1 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
VVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|679205.4.peg.2025
Escherichia coli MS 124-1 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
VVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|749544.3.peg.1434
Escherichia coli MS 175-1 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
VVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|749547.3.peg.2811
Escherichia coli MS 187-1 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
VVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|749548.3.peg.2338
Escherichia coli MS 196-1 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
VVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|749533.3.peg.3273
Escherichia coli MS 84-1 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
VVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|573235.3.peg.5802
Escherichia coli O26:H11 str. 11368 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
VVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|637912.3.peg.922
Escherichia coli OP50 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PEL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
VVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|656379.3.peg.231
Escherichia coli FVEC1302 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAC
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
C
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
K
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
ML
S
A
EV
E
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|749549.3.peg.1021
Escherichia coli MS 198-1 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAC
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
C
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
K
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
ML
S
A
EV
E
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|585056.7.peg.5195
Escherichia coli UMN026 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAC
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
C
Q
E
V
V
-
--
-
--
L
T
AVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
K
IT
L
HVTPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
C
I
ML
S
A
EV
E
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|749545.3.peg.1650
Escherichia coli MS 182-1 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFR
V
NI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
SQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
VVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
N
IT
L
HVMPT
E
VNV
A
A
E
P
A
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
D
QEHV
A
L
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLR
N
V
Q
E
GG
VL
AS
L
fig|439855.10.peg.5048
Escherichia coli SMS-3-5 (2-467/474)
RI
GM
RL
L
L
G-Y
FLLVA
VAA
W
FV
L
AI
FV
-
-
K
EV
K
PG
V
R
----
R
A
T
E
GT
L
I
D
T
A
TL
L
A
EL
ARP
D
LLSG
D
PTHG
QL
AQ
A
F
NQL
Q
H
RPFRANI
G
GIN
K
VR
N
E
Y
H
V
YMT
D
AQGK
VL
F
D
SA
N
KAV
G
Q
D
----
YSR
-----
-
--
-
---
-
-
W
N
D
VW
L
T
L
R
GQ
Y
G
-----
ARSTLQNPADPESSVMYVA
A
P
IM
DG
S
-
R
LI
G
VL
S
VG
-----
KPNA
A
M
APV
IKRSE
R
R
ILW
AS
A
IL
L
G
IAL
V
I
GAG
M
VW
W
I
--
N
---
R
S
I
A
R
L
TRY
A
DSVT
D
NK
P
---V
PL
PDL
G
-
S
SE
L
R
K
L
AQ
AL
ES
M
RVKLE
G
KNYI
E
-
Q
YVYAL
T
HEL
K
SPL
A
A
I
R
GAA
E
ILREGPPPEV
VA
RF
T
DN
IL
TQN
AR
M
QAL
V
E
--
--
-
-----
-
---
--
TL
L
R
QA
RLEN
R
Q
E
V
V
-
--
-
--
L
T
VVD
VA
AL
F
RRVSEA
R
T
V
Q
L
A
E
K
K
IT
L
HVMPT
E
VNV
A
A
E
P
T
LL
EQA
L
G
NLLDNAI
DF
T
P
ES
G
R
I
TL
S
A
EV
E
QEHV
TL
K
V
L
D
T
G
S
GI
P
DY
AL
S
RIFERFY
S
LP
RAN
GQ
K
S
-
-
SGLGLA
F
V
SE
V
A
R
L
F
N
G
E
V
TLH
N
V
Q
E
GG
VL
AS
L
Consen1
Primary consensus
MKFTQRislRlrL
FLlva
w
-
ll
Fva
k
k
vd
----
l
e
L
l
a
L
el
d
d
----
aqt
nql
h
-------
g
d
l
f
v
d
vL
D
n
---
g
d
----
ysr
g
v
d
w
fvw
t
r
y
-------------------------
p
--
dg
-
r
-
vl
VG
-----
a
apv
q
ilw
A
l
Ial
i
m
wl
--
---
r
la
L
A
d
p
pl
g
-
Se
r
L
alnqm
a
e
q
aHELrsPL
alr
E
----------
va
sDn
--
Ar
qAL
e
--
i
l
llTl
RldrleN
q
v
e
l
ll
vadi
------
taq
adk
vrl
g
a
dp
Ll
l
NLLdNAiry
p
s
v
sl
d
tliV
D
GpGi
peal
rIfErFyrlp
gq
s
gsGLGLaiV
iA
l
gg
V
n
e
GG
as
SW
Consen2
Secondary consensus
lgm
vl
s
gfvv
t
-
r
t
lr
a
d
r
ti
e
-
pthg
gka
k
m
-
rpfrani
-
k
n
y
p
h
-
kav
-
-
ipysiqm
-
-
-
y
dlq
i
-
-
g
arstlqnpadpessvmyva
-
im
--
y
-
g
--
qewey
-
viy
r
rpl
a
mi
l
v
l
phwq
l
m
l
hf
-
v
s
e
sfesl
g
k
r
t
kt
rik
ilregpppev
--
t
dil
e
k
lh
-
-
--
y
qasp
l
l
-
-
wt
lmal
rrvsea
-
vv
p
i
iti
e
t
m
m
v
n
df
-
g
i
ta
s
fk
s
v
dynr
h
g
p
vspd
dr
-
c
sf
v
a
nm
t
q
fk
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character