┌─ Escherichia coli (12-421/433) APEC O1 (13)  
                                                            ┌┴─ Escherichia coli (12-421/433) MS 185-1   
                                                           ┌┴─ Escherichia coli (12-421/433) NC101   
                                                          ┌┴─ Escherichia coli (12-421/433) MS 200-1   
                                                         ┌┴─ Escherichia coli (12-421/433) 536 (2)  
                                                        ┌┴┬─ Escherichia coli (12-421/433) B354   
                                                       ┌┤ └─ Escherichia coli (12-421/433) TA143   
                                                       │└┬─ Escherichia coli (12-421/433) TA280   
                                                      ┌┤ └─ Escherichia coli (12-421/433) MS 21-1   
                                                      ││┌─ Escherichia coli (12-421/433) K12 (12)  
                                                      │└┤┌─ Escherichia coli (12-421/433) B088 (13)  
                                                      │ └┤┌─ Escherichia coli (12-421/433) E24377A (1)  
                                                      │  └┤┌─ Escherichia coli (12-421/433) B171 (4)  
                                                     ┌┤   └┤ ┌─ fig|6666666.5357.peg.3540 TY-2482 (12-421/433) strain (8)  
                                                     ││    └┬┴─ Escherichia coli (12-421/433) MS 182-1 (1)  
                                                     ││     └┬─ Escherichia coli (12-421/433) H299   
                                                    ┌┤│      └─ Escherichia coli (12-421/433) 042 (11)  
                                                    ││└─ Escherichia coli (12-421/433) SMS-3-5   
                                                    │└┬─ Escherichia coli (12-421/433) B185   
  ┌─────────────────────────────────────────────────┤ └┬─ Escherichia coli (12-421/433) M718   
  │                                                 │  └┬─ Escherichia coli (12-421/433) 1044A (22)  
┌─┤                                                 │   └─ Escherichia coli (12-421/433) O157:H7 (1)  
│ │                                                 └─ Escherichia coli (12-421/433) 101-1 (12)  
│ └─────────────────────────────────────────────────────────────────┬─ Escherichia coli (1-456/466) APEC O1 (5)  
│                                                                   └─ fig|6666666.5357.peg.3582 TY-2482 (1-456/466) strain (2)  
│                                                                     ┌─ Escherichia coli (2-467/474) 53638 (1)  
│                                                                    ┌┴─ Escherichia coli (2-467/474) ATCC 8739 (1)  
│                                                                   ┌┴─ Escherichia coli (2-467/474) ETEC H10407   
│                                                                  ┌┴─ Escherichia coli (2-467/474) 042 (18)  
│                                                                 ┌┴─ Escherichia coli (2-467/474) MS 182-1   
│                                                                ┌┴┬─ Escherichia coli (2-467/474) O157:H7 EDL933 (1)  
│                                                                │ └┬─ Escherichia coli (2-467/474) O55:H7 str. CB9615   
│                                                               ┌┤  └┬─ Escherichia coli (2-467/474) O157:H7 str. EC4401 (1)  
│                                                               ││   └─ Escherichia coli (2-467/474) 1044A (20)  
│                                                              ┌┤└─ Escherichia coli (2-467/474) SMS-3-5   
│                                                              ││┌─ Escherichia coli (2-467/474) 536 (5)  
│                                                              │└┤┌─ Escherichia coli (2-467/474) H299   
│                                                              │ └┤  ┌─ Escherichia coli (2-467/474) H736   
│                                                              │  │ ┌┴─ Escherichia coli (2-467/474) MS 146-1   
│                                                              │  └┬┴─ Escherichia coli (2-467/474) MS 78-1   
┤                                                             ┌┤   └┬─ fig|1040638.4.peg.818 O104:H4 (2-467/474) str. LB226692 (4)  
│                                                             ││    └┬─ Escherichia coli (2-467/474) E22 (1)  
│                                                             ││     └┬─ Escherichia coli (2-467/474) B088 (18)  
│                                                             ││      └┬─ Escherichia coli (2-467/474) TA271   
│                                                             ││       └─ Escherichia coli (2-467/474) MS 145-7   
│                                                            ┌┤└┬─ Escherichia coli (2-467/474) IAI39 (1)  
│                                                            ││ └┬─ Escherichia coli (2-467/474) ED1a (3)  
│                                                            ││  └┬─ Escherichia coli (2-467/474) TA206   
│                                                            ││   └┬─ Escherichia coli (2-467/474) MS 185-1   
│                                                           ┌┤│    └─ Escherichia coli (2-467/474) 83972 (12)  
│                                                           ││└┬─ Escherichia coli (2-467/474) TA280   
│                                                           ││ └─ Escherichia coli (2-467/474) B185   
│                                                           ││ ┌─ Escherichia coli (2-467/474) SE15   
│                 ┌─────────────────────────────────────────┤└┬┴─ Escherichia coli (2-467/474) FVEC1302 (2)  
│                 │                                         │ └┬─ Escherichia coli (2-467/474) K12 (11)  
│                 │                                         │  └┬─ Escherichia coli (2-467/474) DH1   
│                 │                                         │   └─ Escherichia coli (2-467/474) TA143   
│                 │                                         └─ Escherichia coli (2-467/474) B354   
│                 │                             ┌─ fig|1040638.4.peg.2368 O104:H4 str. LB226692 (25)  
└─────────────────┤                            ┌┴─ Escherichia coli E22 (1)  
                  │                           ┌┴─ Escherichia coli IAI39 (1)  
                  │                          ┌┴─ Escherichia coli E110019 (1)  
                  │                         ┌┴┬─ Escherichia coli H299   
                  │                         │ └┬─ Escherichia coli 1044A (23)  
                  │                         │  └─ Escherichia coli M718   
                  │                         │  ┌─ Escherichia coli 2362-75   
                  └─────────────────────────┤ ┌┴─ Escherichia coli E2348/69 (1)  
                                            │┌┴─ Escherichia coli 042 (2)  
                                            ││  ┌─ Escherichia coli B354   
                                            ││ ┌┴─ Escherichia coli TA280   
                                            └┤┌┴─ Escherichia coli MS 78-1   
                                             ││      ┌─ Escherichia coli 1827-70   
                                             ││     ┌┴─ Escherichia coli 53638 (1)  
                                             ││    ┌┴─ Escherichia coli K12 (21)  
                                             └┤   ┌┴─ Escherichia coli MS 187-1   
                                              │  ┌┴─ Escherichia coli 101-1   
                                              │ ┌┴─ Escherichia coli ATCC 8739 (1)  
                                              │┌┴┬─ Escherichia coli B185   
                                              ││ └┬─ Escherichia coli MS 84-1   
                                              └┤  └─ Escherichia coli MS 124-1   
                                               │ ┌─ Escherichia coli MS 69-1   
                                               │┌┴─ Escherichia coli MS 196-1   
                                               └┤┌─ Escherichia coli WV_060327   
                                                └┤┌─ Escherichia coli 536 (1)  
                                                 └┤┌─ Escherichia coli M605   
                                                  └┤ ┌─ Escherichia coli APEC O1 (6)  
                                                   └┬┴─ Escherichia coli MS 200-1   
                                                    └┬─ Escherichia coli NC101 (1)  
                                                     └┬─ Escherichia coli F11 (2)  
                                                      └┬─ Escherichia coli ED1a (1)  
                                                       └─ Escherichia coli 83972 (6)  
  
Sensory histidine kinase QseC (32)
Two-component response regulator CreC (32)
Sensory histidine kinase in two-component regulatory system with RstA (22)
Heavy metal sensor histidine kinase (1)
Others (4)