fig|1040638.4.peg.2354
Escherichia coli O104:H4 str. LB226692
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLKN
WKSTA
fig|6666666.5357.peg.2236
Escherichia coli TY-2482 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|585055.6.peg.3463
Escherichia coli 55989 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|585055.8.peg.3467
Escherichia coli 55989 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|550672.3.peg.3259
Escherichia coli B088 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|340184.3.peg.2628
Escherichia coli B7A (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|340184.6.peg.2749
Escherichia coli B7A (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|340186.3.peg.522
Escherichia coli E110019 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|340186.5.peg.545
Escherichia coli E110019 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|331111.12.peg.3751
Escherichia coli E24377A (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|331111.3.peg.1167
Escherichia coli E24377A (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|585034.4.peg.3098
Escherichia coli IAI1 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|585034.5.peg.3096
Escherichia coli IAI1 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|679207.4.peg.3724
Escherichia coli MS 107-1 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|679204.3.peg.733
Escherichia coli MS 145-7 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|585396.4.peg.3972
Escherichia coli O111:H- str. 11128 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|573235.3.peg.4212
Escherichia coli O26:H11 str. 11368 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|409438.11.peg.3465
Escherichia coli SE11 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|216592.1.peg.3921
Escherichia coli 042 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|216592.3.peg.3431
Escherichia coli 042 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|358709.5.peg.1228
Escherichia coli 101-1 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|670888.3.peg.3246
Escherichia coli 1827-70 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|670897.3.peg.4316
Escherichia coli 2362-75 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|362663.8.peg.3120
Escherichia coli 536 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|362663.9.peg.3131
Escherichia coli 536 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|344610.3.peg.835
Escherichia coli 53638 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|344610.7.peg.3238
Escherichia coli 53638 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|481805.3.peg.728
Escherichia coli ATCC 8739 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|481805.6.peg.724
Escherichia coli ATCC 8739 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|413997.3.peg.3022
Escherichia coli B str. REL606 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|550676.3.peg.3168
Escherichia coli B185 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|511693.5.peg.3031
Escherichia coli BL21 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|469008.4.peg.743
Escherichia coli BL21(DE3) (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|595496.3.peg.2990
Escherichia coli BW2952 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|536056.3.peg.720
Escherichia coli DH1 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|216593.1.peg.5144
Escherichia coli E2348/69 (9-366/395)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|316401.4.peg.3729
Escherichia coli ETEC H10407 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|340197.3.peg.2650
Escherichia coli F11 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|340197.5.peg.2777
Escherichia coli F11 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|656379.3.peg.3748
Escherichia coli FVEC1302 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|656380.3.peg.3669
Escherichia coli FVEC1412 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|656393.3.peg.4050
Escherichia coli H299 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|656414.3.peg.3473
Escherichia coli H736 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|331112.3.peg.2981
Escherichia coli HS (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|331112.6.peg.3117
Escherichia coli HS (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|585057.4.peg.3627
Escherichia coli IAI39 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|585057.6.peg.3635
Escherichia coli IAI39 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|83333.1.peg.2959
Escherichia coli K12 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|656417.3.peg.3831
Escherichia coli M605 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|749537.3.peg.703
Escherichia coli MS 115-1 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|749538.3.peg.3896
Escherichia coli MS 116-1 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|749540.3.peg.289
Escherichia coli MS 146-1 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|749545.3.peg.1773
Escherichia coli MS 182-1 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|749549.3.peg.5082
Escherichia coli MS 198-1 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|749531.3.peg.83
Escherichia coli MS 69-1 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|574521.7.peg.3362
Escherichia coli O127:H6 str. E2348/69 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|431946.3.peg.2969
Escherichia coli SE15 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|439855.10.peg.3453
Escherichia coli SMS-3-5 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|656444.3.peg.4258
Escherichia coli TA280 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|585056.7.peg.3670
Escherichia coli UMN026 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|316407.3.peg.2898
Escherichia coli W3110 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|316385.5.peg.3139
Escherichia coli str. K-12 substr. DH10B (9-366/395)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|316385.7.peg.3209
Escherichia coli str. K-12 substr. DH10B (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|511145.12.peg.3106
Escherichia coli str. K-12 substr. MG1655 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|511145.6.peg.3091
Escherichia coli str. K-12 substr. MG1655 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|562.375.peg.646
Escherichia coli EC4100B (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
G
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|656408.3.peg.3413
Escherichia coli H591 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
G
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|595495.4.peg.1178
Escherichia coli KO11 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
G
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|679206.4.peg.1367
Escherichia coli MS 119-7 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
G
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|679205.4.peg.500
Escherichia coli MS 124-1 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
G
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|749533.3.peg.3632
Escherichia coli MS 84-1 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
G
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|656443.3.peg.4035
Escherichia coli TA271 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
G
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|566546.3.peg.595
Escherichia coli W (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
G
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|566546.4.peg.3245
Escherichia coli W (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
G
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|550677.3.peg.3572
Escherichia coli B354 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
I
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|344601.3.peg.463
Escherichia coli B171 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
E
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|344601.5.peg.462
Escherichia coli B171 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
E
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|340185.3.peg.379
Escherichia coli E22 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
E
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|340185.4.peg.418
Escherichia coli E22 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
E
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|562.371.peg.2308
Escherichia coli 1044A (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
LG
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|562.373.peg.1786
Escherichia coli 1125A (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
LG
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|562.372.peg.2504
Escherichia coli 1212A (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
LG
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|562.374.peg.4581
Escherichia coli 536A (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
LG
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|83334.1.peg.3871
Escherichia coli O157:H7 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
LG
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|155864.1.peg.3896
Escherichia coli O157:H7 EDL933 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
LG
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|155864.8.peg.3818
Escherichia coli O157:H7 EDL933 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
LG
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|444454.5.peg.2944
Escherichia coli O157:H7 str. EC4024 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
LG
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|444449.5.peg.2402
Escherichia coli O157:H7 str. EC4042 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
LG
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|444448.5.peg.1155
Escherichia coli O157:H7 str. EC4045 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
LG
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|444453.5.peg.3283
Escherichia coli O157:H7 str. EC4076 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
LG
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|444452.5.peg.621
Escherichia coli O157:H7 str. EC4113 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
LG
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|444450.8.peg.4239
Escherichia coli O157:H7 str. EC4115 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
LG
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|444451.5.peg.1041
Escherichia coli O157:H7 str. EC4196 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
LG
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|444447.5.peg.1312
Escherichia coli O157:H7 str. EC4206 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
LG
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|478004.5.peg.840
Escherichia coli O157:H7 str. EC4401 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
LG
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|478005.5.peg.1176
Escherichia coli O157:H7 str. EC4486 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
LG
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|478006.5.peg.729
Escherichia coli O157:H7 str. EC4501 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
LG
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|478007.5.peg.462
Escherichia coli O157:H7 str. EC508 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
LG
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|478008.5.peg.1212
Escherichia coli O157:H7 str. EC869 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
LG
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|637388.3.peg.5104
Escherichia coli O157:H7 str. FRIK2000 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
LG
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|570506.3.peg.708
Escherichia coli O157:H7 str. FRIK966 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
LG
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|386585.9.peg.4063
Escherichia coli O157:H7 str. Sakai (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
LG
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|544404.4.peg.4048
Escherichia coli O157:H7 str. TW14359 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
LG
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|502346.5.peg.3364
Escherichia coli O157:H7 str. TW14588 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
LG
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|701177.3.peg.3751
Escherichia coli O55:H7 str. CB9615 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
LG
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|749527.3.peg.656
Escherichia coli MS 21-1 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DT
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|749548.3.peg.722
Escherichia coli MS 196-1 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
K
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|749550.3.peg.4054
Escherichia coli MS 200-1 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
N
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|749547.3.peg.3953
Escherichia coli MS 187-1 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QPFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|749532.3.peg.659
Escherichia coli MS 78-1 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AC
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|405955.13.peg.3424
Escherichia coli APEC O1 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
SRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|405955.9.peg.2840
Escherichia coli APEC O1 (9-366/395)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
SRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|199310.1.peg.3659
Escherichia coli CFT073 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
SRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|199310.4.peg.3523
Escherichia coli CFT073 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
SRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|585397.7.peg.3657
Escherichia coli ED1a (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
SRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|585397.9.peg.3655
Escherichia coli ED1a (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
SRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|714962.3.peg.3464
Escherichia coli IHE3034 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
SRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|753642.3.peg.4970
Escherichia coli NC101 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
SRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|685038.3.peg.3049
Escherichia coli O83:H1 str. NRG 857C (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
SRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|585035.6.peg.3324
Escherichia coli S88 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
SRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|869729.3.peg.279
Escherichia coli UM146 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
SRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|364106.7.peg.3399
Escherichia coli UTI89 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
SRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|364106.8.peg.3400
Escherichia coli UTI89 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
SRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|562.376.peg.3863
Escherichia coli WV_060327 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
SRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|656419.3.peg.3986
Escherichia coli M718 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
T
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYP
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|656437.3.peg.3422
Escherichia coli TA143 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
S
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
THVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|585395.4.peg.3857
Escherichia coli O103:H2 str. 12009 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPN
Q
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
E
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
E
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|525281.3.peg.3525
Escherichia coli 83972 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
L
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|655817.3.peg.3568
Escherichia coli ABU 83972 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
L
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|749546.3.peg.1930
Escherichia coli MS 185-1 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
L
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|749528.3.peg.521
Escherichia coli MS 45-1 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
D
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
PRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
L
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|656440.3.peg.3231
Escherichia coli TA206 (1-358/387)
MNNFNLHTP
T
R
ILFG
K
GAI
AG
L
R
EQ
I
PH-
N
A
R
VL
ITYGG
GS
V
KKT
G
VLD
QV
L
D
A
L
-
-
K
G
M
DVLE
F
G
G
I
EPNP
A
YET
L
MN
A
VK
L
VREQ
K
V
T
F
L
L
A
V
GGGS
V
L
D
GT
K
F
I
AAAA
N
Y
P
--------
E
NID
P
WH
IL
QT
GGK
E
IKS
-----------------
AIP
M
G
C
V
L
T
L
P
A
TGSE
SN
AG
AVI
SR
KTT
G
D
K
QAFH
S
AHVQ
P
VF
A
V
LD
P
VYTYT
L
P
SRQV
A
N
G
V
VDA
F
V
H
T
V
E
Q
YVT
KP
V
DA
K
IQ
D
RF
A
EG
I
L
LT
L
IED
G
P
K
A
LKEP
-
E
N
YD
V
R
A
N
V
MW
A
A
T
Q
A
L
N
G
L
I
G
AG
VPQDW
AT
H
M
LG
H
E
L
T
AM
H
GL
D
H
A
Q
TL
AI
V
LP
A
L
WNE
KR
D
---------------
TK
R
A
K
L
LQY
A
ER
V
-
WNITEG
S
DD
E
R
I
D
AA
I
A
A
TRN
F
FE
QLG
V
P
T
HL
S
D
Y
G
L
DG
SS
IPALLK
fig|656440.3.peg.4349
Escherichia coli TA206 (1-356/383)
M
S
TSTFFI
P
P
V
N
M
L
G
T
G
S
L
QE
A
I
RM
M
TSY
G
F
R
QS
LIVTD
SI
L
VRL
G
IVA
N
I
Q
N
A
L
L
EH
G
I
SSVV
Y
D
G
TS
PNPT
TEN
V
SE
G
LR
I
LSDN
H
C
D
S
V
I
SL
GGGSP
H
D
CA
K
G
I
ALVA
A
N
G
--
G
D
I
R
NY
E
GVD
R
SE
--
R
P
---
-
---
-----------------
QLP
M
I
A
I
N
TT
A
GT
A
SE
M
T
RF
C
I
ITD
RAR
H
V
K
MAIV
D
KHVT
P
LL
S
V
N
DA
ALMLG
MP
PSLT
A
A
T
G
M
DA
L
THA
V
E
A
YV
S
TA
A
TP
-
IT
D
AC
A
LK
A
I
TM
I
TEN
LP
V
V
VADG
-
N
N
EA
ARE
N
M
AY
A
Q
F
M
AG
M
A
F
N
NA
S
LG
---
YV
H
A
MAH
Q
LG
GF
Y
DL
PHG
V
C
NA
V
LLP
H
V
QEF
N
S
R
---------------
VA
A
G
RL
RDC
A
AA
M
G
VNVTGK
T
DE
E
G
A
A
A
C
I
S
A
IRE
L
AG
K
V
N
IP
T
G
L
K
A
L
N
V
RE
G
DIP
V
L
AA
N
fig|562.376.peg.3623
Escherichia coli WV_060327 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
I
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|405955.13.peg.3110
Escherichia coli APEC O1 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
I
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
T
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|405955.9.peg.2576
Escherichia coli APEC O1 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
I
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
T
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|714962.3.peg.3212
Escherichia coli IHE3034 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
I
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
T
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|585035.6.peg.3010
Escherichia coli S88 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
I
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
T
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|869729.3.peg.551
Escherichia coli UM146 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
I
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
T
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|364106.7.peg.3148
Escherichia coli UTI89 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
I
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
T
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|364106.8.peg.3149
Escherichia coli UTI89 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
I
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
T
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|525281.3.peg.4533
Escherichia coli 83972 (14-353/383)
FGRGA
V
GS
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
I
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|655817.3.peg.3194
Escherichia coli ABU 83972 (14-353/383)
FGRGA
V
GS
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
I
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|199310.1.peg.3287
Escherichia coli CFT073 (14-353/383)
FGRGA
V
GS
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
I
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|199310.4.peg.3170
Escherichia coli CFT073 (14-353/383)
FGRGA
V
GS
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
I
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|656417.3.peg.3555
Escherichia coli M605 (14-353/383)
FGRGA
V
GS
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
I
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|749546.3.peg.3113
Escherichia coli MS 185-1 (14-353/383)
FGRGA
V
GS
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
I
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|749528.3.peg.1766
Escherichia coli MS 45-1 (14-353/383)
FGRGA
V
GS
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
I
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|753642.3.peg.349
Escherichia coli NC101 (14-353/383)
FGRGA
V
GS
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
I
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|685038.3.peg.2796
Escherichia coli O83:H1 str. NRG 857C (14-353/383)
FGRGA
V
GS
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
I
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|656440.3.peg.2823
Escherichia coli TA206 (14-353/383)
FGRGA
V
GS
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
I
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|585397.7.peg.3261
Escherichia coli ED1a (14-353/383)
FGRGA
V
GS
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
I
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
HDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|585397.9.peg.3256
Escherichia coli ED1a (14-353/383)
FGRGA
V
GS
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
I
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
HDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|749527.3.peg.1207
Escherichia coli MS 21-1 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
CT
G
E
KY
RDI
A
RV
M
G
VKAEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|362663.8.peg.2817
Escherichia coli 536 (14-353/383)
FGRGA
V
GS
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
I
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VV--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|362663.9.peg.2824
Escherichia coli 536 (14-353/383)
FGRGA
V
GS
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
I
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VV--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|340197.3.peg.1268
Escherichia coli F11 (14-353/383)
FGRGA
V
GS
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
I
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VV--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|340197.5.peg.1333
Escherichia coli F11 (14-353/383)
FGRGA
V
GS
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
I
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VV--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|749550.3.peg.764
Escherichia coli MS 200-1 (14-353/383)
FGRGA
V
GS
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
I
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VV--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|573235.3.peg.4815
Escherichia coli O26:H11 str. 11368 (2-353/382)
S
F
M
L
AL
PK
I
S
L
H
G
A
GAI
GD
M
V
N
L
V
AHK
Q
W
G
KA
LIVTD
GQ
L
VKL
G
LLD
S
L
F
I
A
L
D
QYE
M
SYHL
F
D
E
V
F
PNPT
EEL
V
QK
G
YA
A
FQDA
A
C
D
Y
I
IA
F
GGGSP
I
D
TA
K
A
V
KILT
A
N
P
--
A
PSTAYS
GVG
K
VT
--
N
P
---
-
---
-----------------
GVP
L
V
A
I
N
TT
A
GT
AA
E
M
T
SN
AVI
I
D
TAR
Q
V
K
EVII
D
PNII
P
DI
A
V
D
DA
SVMLE
I
P
ASVT
A
A
T
G
M
DA
L
THA
V
E
A
YV
S
VG
A
HP
-
LT
D
AN
A
LE
A
I
RL
I
TLW
LP
K
A
VDDG
-
H
N
LE
ARE
Q
M
AF
A
Q
Y
L
AG
M
A
F
N
S
AGLG
---
LV
H
A
L
AH
Q
P
G
AT
H
NL
PHG
V
C
NAILLP
V
I
ENF
N
R
P
---------------
NA
I
A
R
F
ARI
A
QA
M
G
VDTRDM
S
EE
A
A
S
T
E
A
I
N
A
IRA
L
SH
R
V
GIP
A
GF
S
Q
L
G
I
TK
EDI
EGW
L
fig|431946.3.peg.2714
Escherichia coli SE15 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|1040638.4.peg.2695
Escherichia coli O104:H4 str. LB226692 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|6666666.5357.peg.3812
Escherichia coli TY-2482 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|562.371.peg.5820
Escherichia coli 1044A (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|562.373.peg.4312
Escherichia coli 1125A (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|562.372.peg.2241
Escherichia coli 1212A (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|670888.3.peg.3509
Escherichia coli 1827-70 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|344610.3.peg.4081
Escherichia coli 53638 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|344610.7.peg.3471
Escherichia coli 53638 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|562.374.peg.3881
Escherichia coli 536A (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|585055.6.peg.3119
Escherichia coli 55989 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|585055.8.peg.3122
Escherichia coli 55989 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|550672.3.peg.3020
Escherichia coli B088 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|344601.3.peg.741
Escherichia coli B171 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|344601.5.peg.767
Escherichia coli B171 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|550677.3.peg.3332
Escherichia coli B354 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|340184.3.peg.3650
Escherichia coli B7A (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|340184.6.peg.3813
Escherichia coli B7A (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|595496.3.peg.2782
Escherichia coli BW2952 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|536056.3.peg.928
Escherichia coli DH1 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|340186.3.peg.4326
Escherichia coli E110019 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|340186.5.peg.4547
Escherichia coli E110019 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|340185.3.peg.3515
Escherichia coli E22 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|340185.4.peg.3696
Escherichia coli E22 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|331111.12.peg.3384
Escherichia coli E24377A (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|331111.3.peg.820
Escherichia coli E24377A (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|562.375.peg.1143
Escherichia coli EC4100B (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|316401.4.peg.3388
Escherichia coli ETEC H10407 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|656379.3.peg.4168
Escherichia coli FVEC1302 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|656380.3.peg.4084
Escherichia coli FVEC1412 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|656408.3.peg.3092
Escherichia coli H591 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|656414.3.peg.3234
Escherichia coli H736 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|585034.4.peg.2860
Escherichia coli IAI1 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|585034.5.peg.2857
Escherichia coli IAI1 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|83333.1.peg.2755
Escherichia coli K12 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|595495.4.peg.2586
Escherichia coli KO11 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|679207.4.peg.785
Escherichia coli MS 107-1 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|749538.3.peg.3705
Escherichia coli MS 116-1 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
A
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|679206.4.peg.379
Escherichia coli MS 119-7 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|679205.4.peg.3053
Escherichia coli MS 124-1 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|679204.3.peg.2406
Escherichia coli MS 145-7 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|749540.3.peg.1805
Escherichia coli MS 146-1 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|749545.3.peg.1364
Escherichia coli MS 182-1 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|749548.3.peg.2870
Escherichia coli MS 196-1 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|749549.3.peg.2184
Escherichia coli MS 198-1 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|749531.3.peg.5236
Escherichia coli MS 69-1 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|749532.3.peg.751
Escherichia coli MS 78-1 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|749533.3.peg.4102
Escherichia coli MS 84-1 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|585395.4.peg.3501
Escherichia coli O103:H2 str. 12009 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|585396.4.peg.3647
Escherichia coli O111:H- str. 11128 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|83334.1.peg.3647
Escherichia coli O157:H7 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|155864.1.peg.3662
Escherichia coli O157:H7 EDL933 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|155864.8.peg.3581
Escherichia coli O157:H7 EDL933 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|444454.5.peg.2701
Escherichia coli O157:H7 str. EC4024 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|444449.5.peg.2162
Escherichia coli O157:H7 str. EC4042 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|444448.5.peg.917
Escherichia coli O157:H7 str. EC4045 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|444453.5.peg.398
Escherichia coli O157:H7 str. EC4076 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|444452.5.peg.3921
Escherichia coli O157:H7 str. EC4113 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|444450.8.peg.4004
Escherichia coli O157:H7 str. EC4115 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|444447.5.peg.1067
Escherichia coli O157:H7 str. EC4206 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|478004.5.peg.4782
Escherichia coli O157:H7 str. EC4401 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|478005.5.peg.954
Escherichia coli O157:H7 str. EC4486 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|478006.5.peg.4815
Escherichia coli O157:H7 str. EC4501 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|478007.5.peg.4264
Escherichia coli O157:H7 str. EC508 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|478008.5.peg.3264
Escherichia coli O157:H7 str. EC869 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|637388.3.peg.3203
Escherichia coli O157:H7 str. FRIK2000 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|570506.3.peg.2517
Escherichia coli O157:H7 str. FRIK966 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|386585.9.peg.3825
Escherichia coli O157:H7 str. Sakai (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|544404.4.peg.3808
Escherichia coli O157:H7 str. TW14359 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|502346.5.peg.3602
Escherichia coli O157:H7 str. TW14588 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|573235.3.peg.3958
Escherichia coli O26:H11 str. 11368 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|701177.3.peg.3471
Escherichia coli O55:H7 str. CB9615 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|409438.11.peg.3231
Escherichia coli SE11 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|656437.3.peg.3131
Escherichia coli TA143 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|656443.3.peg.3564
Escherichia coli TA271 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|656444.3.peg.3911
Escherichia coli TA280 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|585056.7.peg.3309
Escherichia coli UMN026 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|566546.3.peg.2896
Escherichia coli W (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|566546.4.peg.2978
Escherichia coli W (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|316407.3.peg.2701
Escherichia coli W3110 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|316385.5.peg.2931
Escherichia coli str. K-12 substr. DH10B (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|316385.7.peg.2996
Escherichia coli str. K-12 substr. DH10B (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|511145.12.peg.2899
Escherichia coli str. K-12 substr. MG1655 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|511145.6.peg.2884
Escherichia coli str. K-12 substr. MG1655 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|439855.10.peg.3096
Escherichia coli SMS-3-5 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
LKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|358709.5.peg.4406
Escherichia coli 101-1 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
I
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|413997.3.peg.2773
Escherichia coli B str. REL606 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
I
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|511693.5.peg.2788
Escherichia coli BL21 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
I
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|469008.4.peg.951
Escherichia coli BL21(DE3) (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
I
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|749547.3.peg.3371
Escherichia coli MS 187-1 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
I
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|637912.3.peg.801
Escherichia coli OP50 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
I
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|331112.3.peg.2754
Escherichia coli HS (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFV
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|331112.6.peg.2878
Escherichia coli HS (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFV
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|550676.3.peg.2730
Escherichia coli B185 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
H
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
KS
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|670897.3.peg.653
Escherichia coli 2362-75 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIP
T
L
fig|216593.1.peg.1265
Escherichia coli E2348/69 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIP
T
L
fig|656393.3.peg.3800
Escherichia coli H299 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIP
T
L
fig|574521.7.peg.3114
Escherichia coli O127:H6 str. E2348/69 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIP
T
L
fig|585057.4.peg.3339
Escherichia coli IAI39 (14-353/383)
FGR
A
A
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|585057.6.peg.3346
Escherichia coli IAI39 (14-353/383)
FGR
A
A
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LD
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|585396.4.peg.4897
Escherichia coli O111:H- str. 11128 (2-353/382)
S
F
M
L
AL
PK
I
S
L
H
G
A
GAI
GD
M
V
N
L
V
AHK
Q
W
G
KA
LIVTD
GQ
L
VKL
G
LLD
S
L
F
I
A
L
D
QYE
M
SYHL
F
D
E
V
F
PNPT
EEL
V
QK
G
YA
A
FQDA
A
C
D
Y
I
IA
F
GG
D
SP
I
D
TA
K
A
V
KILT
A
N
P
--
A
PSTAYS
GVG
K
VT
--
N
P
---
-
---
-----------------
GVP
L
V
A
I
N
TT
A
GT
AA
E
M
T
SN
AVI
I
D
TAR
Q
V
K
EVII
D
PNII
P
DI
A
V
D
DA
SVMLE
I
P
ASVT
A
A
T
G
M
DA
L
THA
V
E
A
YV
S
VG
A
HP
-
LT
D
AN
A
LE
A
I
RL
I
TLW
LP
K
A
VDDG
-
H
N
LE
ARE
Q
M
AF
A
Q
Y
L
AG
M
A
F
N
S
AGLG
---
LV
H
A
L
AH
Q
P
G
AT
H
NL
PHG
V
C
NAILLP
V
I
ENF
N
R
P
---------------
NA
I
A
R
F
ARI
A
QA
M
G
VDTRDM
S
EE
A
A
S
T
E
A
I
N
A
IRA
L
SH
R
V
GIP
A
GF
S
Q
L
G
I
TK
EDI
EGW
L
fig|216592.1.peg.3586
Escherichia coli 042 (14-353/383)
FGRGA
V
GA
L
I
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AA
R
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|216592.3.peg.3130
Escherichia coli 042 (14-353/383)
FGRGA
V
GA
L
I
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
D
K
M
D
AA
R
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|481805.3.peg.967
Escherichia coli ATCC 8739 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
H
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|481805.6.peg.966
Escherichia coli ATCC 8739 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
H
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|749537.3.peg.3805
Escherichia coli MS 115-1 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
H
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MRY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|656419.3.peg.3627
Escherichia coli M718 (14-353/383)
FGRGA
V
GA
L
T
DEV
KRR
G
Y
Q
KA
LIVTD
KT
L
VQC
G
VVA
K
V
T
H
K
M
D
AAG
L
AWAI
Y
D
GV
V
PNPT
ITV
V
KE
G
LG
V
FQNS
G
A
D
Y
LIAIGGGSP
Q
D
TC
K
A
I
GIIS
N
N
P
EFADVRSL
E
GLS
P
TN
--
K
P
---
-
---
-----------------
SVP
I
L
A
I
P
TT
A
GT
AA
EVT
IN
Y
VITD
EEK
R
R
K
FVCV
D
PHDI
P
QV
A
F
I
DA
DMMDG
MP
PALK
A
A
T
GVDA
L
THAIE
G
Y
I
T
RG
A
WA
-
LT
D
AL
H
IK
A
I
EI
I
AGA
L
R
G
S
VA--
-
G
D
KD
A
G
E
E
M
AL
G
Q
Y
V
AG
M
GF
S
N
V
GLG
---
LV
H
G
MAH
P
LG
AF
Y
NT
PHG
V
ANAILLP
H
V
MLY
NAD
---------------
FT
G
E
KY
RDI
A
RV
M
G
VKVEGM
S
LE
E
A
R
N
AAV
E
A
VFA
L
NR
D
V
GIP
P
HLRD
V
GV
RK
EDIPAL
fig|749527.3.peg.4795
Escherichia coli MS 21-1 (27-356/395)
P
P
V
T
L
C
G
P
GA
V
SS
C
G
Q
Q
A
QTR
G
L
K
HL
F
VM
A
D
SF
L
HQT
G
MTA
G
L
T
R
S
L
A
V
K
G
I
AMTL
W
P
CP
V
GE
P
C
ITD
V
CA
A
VA
Q
LRES
G
C
D
G
V
IA
F
GGGS
V
L
D
AA
K
A
V
ALLV
T
N
P
----
DST
L
A
EMS
E
TS
V
L
Q
P
---
-
---
-----------------
RLP
L
I
A
I
P
TT
A
GTGSE
T
T
NV
T
VI
I
D
AVS
G
R
K
QVLA
H
ASLM
P
DV
A
I
LDA
ALTEG
V
P
SHVT
A
M
T
G
I
DA
L
THAIE
A
Y
SA
LN
A
TP
-
FT
D
SL
A
IG
A
I
AM
I
GKS
LP
K
A
VGYG
-
H
D
LA
ARE
S
M
LL
A
S
C
M
AG
M
A
F
S
S
AGLG
---
LC
H
A
MAH
Q
P
G
AA
L
HI
PHG
L
ANA
M
LLP
T
V
MEF
N
R
M
---------------
VC
R
D
R
F
SQI
G
RA
L
-
-----R
T
KK
S
D
D
R
D
A
I
N
A
VSE
L
IA
E
V
GI
G
K
R
L
G
D
I
G
fig|585057.4.peg.4349
Escherichia coli IAI39 (9-337/384)
R
I
C
FG
Q
D
A
L
S-
V
L
DE
L
---
T
A
C
HV
L
L
VTD
QA
M
VKF
G
LAE
R
V
T
Q
R
L
C
A
R
G
I
DWQV
W
D
D
V
VAD
P
D
IAT
V
VR
G
MK
L
MDSC
Y
P
D
L
V
IA
L
GGGS
V
I
D
AA
K
A
V
IFAL
A
Q
T
--------
-
---
-
--
--
R
P
EAG
R
E--
-----------------
RPC
F
V
A
I
P
TT
S
GTGSEVT
SF
S
V
V
K-
-AH
A
E
K
LVLV
D
SSLL
P
DI
A
I
LD
P
SLVAS
V
P
PAIT
A
D
T
G
M
D
V
L
C
HA
L
E
A
YV
S
LA
A
SD
-
FS
D
AL
A
EK
V
V
QQ
V
FSY
LP
G
C
WRNG
-
Q
D
LQ
AR
A
K
M
HN
A
S
C
M
AG
M
A
F
T
NA
S
LG
---
IT
H
S
L
AH
A
LG
GV
F
RV
PHG
R
ANA
L
L
M
A
H
V
VAW
NAD
YHGQCD
T
--------
LA
A
R
KY
ARL
A
HL
L
D
LPASTP
R
EG
-
-
V
T
S
L
L
V
A
IQT
L
KD
EM
N
M
P
R
G
I
N
D
T
GV
NA
A
fig|585057.6.peg.4358
Escherichia coli IAI39 (9-337/384)
R
I
C
FG
Q
D
A
L
S-
V
L
DE
L
---
T
A
C
HV
L
L
VTD
QA
M
VKF
G
LAE
R
V
T
Q
R
L
C
A
R
G
I
DWQV
W
D
D
V
VAD
P
D
IAT
V
VR
G
MK
L
MDSC
Y
P
D
L
V
IA
L
GGGS
V
I
D
AA
K
A
V
IFAL
A
Q
T
--------
-
---
-
--
--
R
P
EAG
R
E--
-----------------
RPC
F
V
A
I
P
TT
S
GTGSEVT
SF
S
V
V
K-
-AH
A
E
K
LVLV
D
SSLL
P
DI
A
I
LD
P
SLVAS
V
P
PAIT
A
D
T
G
M
D
V
L
C
HA
L
E
A
YV
S
LA
A
SD
-
FS
D
AL
A
EK
V
V
QQ
V
FSY
LP
G
C
WRNG
-
Q
D
LQ
AR
A
K
M
HN
A
S
C
M
AG
M
A
F
T
NA
S
LG
---
IT
H
S
L
AH
A
LG
GV
F
RV
PHG
R
ANA
L
L
M
A
H
V
VAW
NAD
YHGQCD
T
--------
LA
A
R
KY
ARL
A
HL
L
D
LPASTP
R
EG
-
-
V
T
S
L
L
V
A
IQT
L
KD
EM
N
M
P
R
G
I
N
D
T
GV
NA
A
fig|362663.8.peg.4618
Escherichia coli 536 (9-337/384)
R
I
C
FG
Q
D
A
L
S-
V
L
DE
L
---
T
A
C
HV
L
L
VTD
QA
M
VKF
G
LAE
R
V
T
Q
R
L
C
A
R
G
I
DWQV
W
D
D
V
VAD
P
D
IAT
V
VR
G
MK
L
MDSC
Y
P
D
L
V
IA
L
GGGS
V
I
D
AA
K
A
V
IFAL
A
Q
T
--------
-
---
-
--
--
R
P
EAG
R
E--
-----------------
RPC
F
V
A
I
P
TT
S
GTGSEVT
SF
S
V
V
K-
-AH
A
E
K
LVLV
D
SSLL
P
DI
A
I
LD
P
SLVAS
V
P
PAIT
A
D
T
G
M
D
V
L
C
HA
L
E
A
YV
S
LA
A
SD
-
FS
D
AL
A
EK
V
V
QQ
V
FSY
LP
G
C
WRNG
-
Q
D
LQ
ARE
K
M
HN
A
S
C
M
AG
M
A
F
T
NA
S
LG
---
IT
H
S
L
AH
A
LG
GV
F
RV
PHG
R
ANA
L
L
M
A
H
V
VAW
NAD
YHGQCD
T
--------
LA
A
R
KY
ARL
A
HL
L
D
LPASTP
R
EG
-
-
V
T
S
L
L
V
A
IQT
L
KD
EM
N
M
P
R
G
I
N
D
T
GV
NA
A
fig|362663.9.peg.4635
Escherichia coli 536 (9-337/384)
R
I
C
FG
Q
D
A
L
S-
V
L
DE
L
---
T
A
C
HV
L
L
VTD
QA
M
VKF
G
LAE
R
V
T
Q
R
L
C
A
R
G
I
DWQV
W
D
D
V
VAD
P
D
IAT
V
VR
G
MK
L
MDSC
Y
P
D
L
V
IA
L
GGGS
V
I
D
AA
K
A
V
IFAL
A
Q
T
--------
-
---
-
--
--
R
P
EAG
R
E--
-----------------
RPC
F
V
A
I
P
TT
S
GTGSEVT
SF
S
V
V
K-
-AH
A
E
K
LVLV
D
SSLL
P
DI
A
I
LD
P
SLVAS
V
P
PAIT
A
D
T
G
M
D
V
L
C
HA
L
E
A
YV
S
LA
A
SD
-
FS
D
AL
A
EK
V
V
QQ
V
FSY
LP
G
C
WRNG
-
Q
D
LQ
ARE
K
M
HN
A
S
C
M
AG
M
A
F
T
NA
S
LG
---
IT
H
S
L
AH
A
LG
GV
F
RV
PHG
R
ANA
L
L
M
A
H
V
VAW
NAD
YHGQCD
T
--------
LA
A
R
KY
ARL
A
HL
L
D
LPASTP
R
EG
-
-
V
T
S
L
L
V
A
IQT
L
KD
EM
N
M
P
R
G
I
N
D
T
GV
NA
A
fig|340197.3.peg.802
Escherichia coli F11 (13-341/388)
R
I
C
FG
Q
D
A
L
S-
V
L
DE
L
---
T
A
C
HV
L
L
VTD
QA
M
VKF
G
LAE
R
V
T
Q
R
L
C
A
R
G
I
DWQV
W
D
D
V
VAD
P
D
IAT
V
VR
G
MK
L
MDSC
Y
P
D
L
V
IA
L
GGGS
V
I
D
AA
K
A
V
IFAL
A
Q
T
--------
-
---
-
--
--
R
P
EAG
R
E--
-----------------
RPC
F
V
A
I
P
TT
S
GTGSEVT
SF
S
V
V
K-
-AH
A
E
K
LVLV
D
SSLL
P
DI
A
I
LD
P
SLVAS
V
P
PAIT
A
D
T
G
M
D
V
L
C
HA
L
E
A
YV
S
LA
A
SD
-
FS
D
AL
A
EK
V
V
QQ
V
FSY
LP
G
C
WRNG
-
Q
D
LQ
ARE
K
M
HN
A
S
C
M
AG
M
A
F
T
NA
S
LG
---
IT
H
S
L
AH
A
LG
GV
F
RV
PHG
R
ANA
L
L
M
A
H
V
VAW
NAD
YHGQCD
T
--------
LA
A
R
KY
ARL
A
HL
L
D
LPASTP
R
EG
-
-
V
T
S
L
L
V
A
IQT
L
KD
EM
N
M
P
R
G
I
N
D
T
GV
NA
A
fig|340197.5.peg.834
Escherichia coli F11 (9-337/384)
R
I
C
FG
Q
D
A
L
S-
V
L
DE
L
---
T
A
C
HV
L
L
VTD
QA
M
VKF
G
LAE
R
V
T
Q
R
L
C
A
R
G
I
DWQV
W
D
D
V
VAD
P
D
IAT
V
VR
G
MK
L
MDSC
Y
P
D
L
V
IA
L
GGGS
V
I
D
AA
K
A
V
IFAL
A
Q
T
--------
-
---
-
--
--
R
P
EAG
R
E--
-----------------
RPC
F
V
A
I
P
TT
S
GTGSEVT
SF
S
V
V
K-
-AH
A
E
K
LVLV
D
SSLL
P
DI
A
I
LD
P
SLVAS
V
P
PAIT
A
D
T
G
M
D
V
L
C
HA
L
E
A
YV
S
LA
A
SD
-
FS
D
AL
A
EK
V
V
QQ
V
FSY
LP
G
C
WRNG
-
Q
D
LQ
ARE
K
M
HN
A
S
C
M
AG
M
A
F
T
NA
S
LG
---
IT
H
S
L
AH
A
LG
GV
F
RV
PHG
R
ANA
L
L
M
A
H
V
VAW
NAD
YHGQCD
T
--------
LA
A
R
KY
ARL
A
HL
L
D
LPASTP
R
EG
-
-
V
T
S
L
L
V
A
IQT
L
KD
EM
N
M
P
R
G
I
N
D
T
GV
NA
A
fig|749550.3.peg.1406
Escherichia coli MS 200-1 (9-337/384)
R
I
C
FG
Q
D
A
L
S-
V
L
DE
L
---
T
A
C
HV
L
L
VTD
QA
M
VKF
G
LAE
R
V
T
Q
R
L
C
A
R
G
I
DWQV
W
D
D
V
VAD
P
D
IAT
V
VR
G
MK
L
MDSC
Y
P
D
L
V
IA
L
GGGS
V
I
D
AA
K
A
V
IFAL
A
Q
T
--------
-
---
-
--
--
R
P
EAG
R
E--
-----------------
RPC
F
V
A
I
P
TT
S
GTGSEVT
SF
S
V
V
K-
-AH
A
E
K
LVLV
D
SSLL
P
DI
A
I
LD
P
SLVAS
V
P
PAIT
A
D
T
G
M
D
V
L
C
HA
L
E
A
YV
S
LA
A
SD
-
FS
D
AL
A
EK
V
V
QQ
V
FSY
LP
G
C
WRNG
-
Q
D
LQ
ARE
K
M
HN
A
S
C
M
AG
M
A
F
T
NA
S
LG
---
IT
H
S
L
AH
A
LG
GV
F
RV
PHG
R
ANA
L
L
M
A
H
V
VAW
NAD
YHGQCD
T
--------
LA
A
R
KY
ARL
A
HL
L
D
LPASTP
R
EG
-
-
V
T
S
L
L
V
A
IQT
L
KD
EM
N
M
P
R
G
I
N
D
T
GV
NA
A
fig|749531.3.peg.2251
Escherichia coli MS 69-1 (9-337/384)
R
I
C
FG
Q
D
A
L
S-
V
L
DE
L
---
T
A
C
HV
L
L
VTD
QA
M
VKF
G
LAE
R
V
T
Q
R
L
C
A
R
G
I
DWQV
W
D
D
V
VAD
P
D
IAT
V
VR
G
MK
L
MDSC
Y
P
D
L
V
IA
L
GGGS
V
I
D
AA
K
A
V
IFAL
A
Q
T
--------
-
---
-
--
--
R
P
EAG
R
E--
-----------------
RPC
F
V
A
I
P
TT
S
GTGSEVT
SF
S
V
V
K-
-AH
A
E
K
LVLV
D
SSLL
P
DI
A
I
LD
P
SLVAS
V
P
PAIT
A
D
T
G
M
D
V
L
C
HA
L
E
A
YV
S
LA
A
SD
-
FS
D
AL
A
EK
V
V
QQ
V
FSY
LP
G
C
WRNG
-
Q
D
LQ
ARE
K
M
HN
A
S
C
M
AG
M
A
F
T
NA
S
LG
---
IT
H
S
L
AH
A
LG
GV
F
RV
PHG
R
ANA
L
L
M
A
H
V
VAW
NAD
YHGQCD
T
--------
LA
A
R
KY
ARL
A
HL
L
D
LPASTP
R
EG
-
-
V
T
S
L
L
V
A
IQT
L
KD
EM
N
M
P
R
G
I
N
D
T
GV
NA
A
fig|869729.3.peg.4734
Escherichia coli UM146 (9-337/384)
R
I
C
FG
Q
D
A
L
S-
V
L
DE
L
---
T
A
C
HV
L
L
VTD
QA
M
VKF
G
LAE
R
V
T
Q
R
L
C
A
R
G
I
DWQV
W
D
D
V
VAD
P
D
IAT
V
VR
G
MK
L
MDSC
Y
P
D
L
V
IA
L
GGGS
V
I
D
AA
K
A
V
IFAL
A
Q
T
--------
-
---
-
--
--
R
P
EAG
R
E--
-----------------
RPC
F
V
A
I
P
TT
S
GTGSEVT
SF
S
V
V
K-
-AH
A
E
K
LVLV
D
SSLL
P
DI
A
I
LD
P
SLVAS
V
P
PAIT
A
D
T
G
M
D
V
L
C
HA
L
E
A
YV
S
LA
A
SD
-
FS
D
AL
A
EK
V
V
QQ
V
FSY
LP
G
C
WRNG
-
Q
D
LQ
ARE
K
M
HN
A
S
C
M
AG
M
A
F
T
NA
S
LG
---
IT
H
S
L
AH
A
LG
GV
F
RV
PHG
R
ANA
L
L
M
A
H
V
VAW
NAD
YHGQCD
T
--------
LA
A
R
KY
ARL
A
HL
L
D
LPASTP
R
EG
-
-
V
T
S
L
L
V
A
IQT
L
KD
EM
N
M
P
R
G
I
N
D
T
GV
NA
A
fig|364106.7.peg.4833
Escherichia coli UTI89 (9-337/384)
R
I
C
FG
Q
D
A
L
S-
V
L
DE
L
---
T
A
C
HV
L
L
VTD
QA
M
VKF
G
LAE
R
V
T
Q
R
L
C
A
R
G
I
DWQV
W
D
D
V
VAD
P
D
IAT
V
VR
G
MK
L
MDSC
Y
P
D
L
V
IA
L
GGGS
V
I
D
AA
K
A
V
IFAL
A
Q
T
--------
-
---
-
--
--
R
P
EAG
R
E--
-----------------
RPC
F
V
A
I
P
TT
S
GTGSEVT
SF
S
V
V
K-
-AH
A
E
K
LVLV
D
SSLL
P
DI
A
I
LD
P
SLVAS
V
P
PAIT
A
D
T
G
M
D
V
L
C
HA
L
E
A
YV
S
LA
A
SD
-
FS
D
AL
A
EK
V
V
QQ
V
FSY
LP
G
C
WRNG
-
Q
D
LQ
ARE
K
M
HN
A
S
C
M
AG
M
A
F
T
NA
S
LG
---
IT
H
S
L
AH
A
LG
GV
F
RV
PHG
R
ANA
L
L
M
A
H
V
VAW
NAD
YHGQCD
T
--------
LA
A
R
KY
ARL
A
HL
L
D
LPASTP
R
EG
-
-
V
T
S
L
L
V
A
IQT
L
KD
EM
N
M
P
R
G
I
N
D
T
GV
NA
A
fig|364106.8.peg.4833
Escherichia coli UTI89 (9-337/384)
R
I
C
FG
Q
D
A
L
S-
V
L
DE
L
---
T
A
C
HV
L
L
VTD
QA
M
VKF
G
LAE
R
V
T
Q
R
L
C
A
R
G
I
DWQV
W
D
D
V
VAD
P
D
IAT
V
VR
G
MK
L
MDSC
Y
P
D
L
V
IA
L
GGGS
V
I
D
AA
K
A
V
IFAL
A
Q
T
--------
-
---
-
--
--
R
P
EAG
R
E--
-----------------
RPC
F
V
A
I
P
TT
S
GTGSEVT
SF
S
V
V
K-
-AH
A
E
K
LVLV
D
SSLL
P
DI
A
I
LD
P
SLVAS
V
P
PAIT
A
D
T
G
M
D
V
L
C
HA
L
E
A
YV
S
LA
A
SD
-
FS
D
AL
A
EK
V
V
QQ
V
FSY
LP
G
C
WRNG
-
Q
D
LQ
ARE
K
M
HN
A
S
C
M
AG
M
A
F
T
NA
S
LG
---
IT
H
S
L
AH
A
LG
GV
F
RV
PHG
R
ANA
L
L
M
A
H
V
VAW
NAD
YHGQCD
T
--------
LA
A
R
KY
ARL
A
HL
L
D
LPASTP
R
EG
-
-
V
T
S
L
L
V
A
IQT
L
KD
EM
N
M
P
R
G
I
N
D
T
GV
NA
A
fig|585035.6.peg.4584
Escherichia coli S88 (10-337/372)
K
I
Y
FG
EE
AI
T-
S
L
C
Q
F
---
N
N
K
RV
G
IVTD
DF
I
MSS
G
KTR
Y
L
I
S
H
M
P
E
A
S
V
--CI
F
G
E
V
T
P
D
P
D
IDI
L
TS
G
AA
R
FKAF
K
P
D
V
I
IA
L
GGGS
S
L
D
AA
K
G
I
KVTL
E
E
Y
--------
-
---
-
--
--
--
-FG
D
H--
-----------------
QID
L
I
A
I
P
TT
S
G
S
GSEVT
SY
A
I
I
S
D
PQN
G
R
K
YPLI
S
GQLV
P
EI
A
I
LD
P
NLVLT
A
P
RHVA
V
D
T
G
M
D
V
L
THAIE
A
F
V
S
TG
S
ND
-
FS
D
AL
A
EK
A
I
AL
T
WRY
LP
Q
V
FNDE
-
K
D
IA
AR
T
H
M
HN
A
S
C
M
AG
M
A
F
N
S
AGLG
---
LV
H
G
MAH
A
I
G
GM
L
HI
PHG
K
I
NA
M
LLP
I
V
IDF
N
S
K
---
RAS
T
--------
ET
R
D
R
Y
HRC
A
QI
I
G
IDHAVP
E
QA
-
-
I
A
LMT
Q
E
IRQ
I
NR
HFC
IP
V
T
L
SE
L
G
I
DR
AK
I
IE
L
fig|358709.5.peg.2404
Escherichia coli 101-1 (10-337/372)
K
I
Y
FG
EE
AI
T-
S
L
C
Q
F
---
N
N
K
RV
G
IVTD
DF
M
MSS
G
KTR
Y
L
I
S
H
M
P
E
A
S
V
--CI
F
G
E
V
T
P
D
P
D
IDI
L
TS
G
AA
R
FKAF
K
P
D
V
I
IA
L
GGGS
S
L
D
AA
K
G
I
KVTL
E
E
Y
--------
-
---
-
--
--
--
-FG
D
H--
-----------------
QID
L
I
A
I
P
TT
S
G
S
GSEVT
SY
A
I
I
S
D
PQN
G
R
K
YPLI
S
GQLV
P
EI
A
I
LD
P
NLVLT
A
P
RHVA
V
D
T
G
M
D
V
L
THAIE
A
F
V
S
TG
S
ND
-
FS
D
AL
A
EK
A
I
AL
T
WRY
LP
Q
V
FNDE
-
K
D
IA
AR
T
H
M
HN
A
S
C
M
AG
M
A
F
N
S
AGLG
---
LV
H
G
MAH
A
I
G
GM
L
HI
PHG
K
I
NA
M
LLP
I
V
IDF
N
S
K
---
RAS
T
--------
ET
R
D
R
Y
HRC
A
QI
I
G
IDHAVP
E
QA
-
-
I
A
LMT
Q
E
IRQ
I
NR
HFC
IP
V
T
L
SE
L
G
I
DR
AK
I
IE
L
fig|405955.13.peg.4683
Escherichia coli APEC O1 (10-337/372)
K
I
Y
FG
EE
AI
T-
S
L
C
Q
F
---
N
N
K
RV
G
IVTD
DF
M
MSS
G
KTR
Y
L
I
S
H
M
P
E
A
S
V
--CI
F
G
E
V
T
P
D
P
D
IDI
L
TS
G
AA
R
FKAF
K
P
D
V
I
IA
L
GGGS
S
L
D
AA
K
G
I
KVTL
E
E
Y
--------
-
---
-
--
--
--
-FG
D
H--
-----------------
QID
L
I
A
I
P
TT
S
G
S
GSEVT
SY
A
I
I
S
D
PQN
G
R
K
YPLI
S
GQLV
P
EI
A
I
LD
P
NLVLT
A
P
RHVA
V
D
T
G
M
D
V
L
THAIE
A
F
V
S
TG
S
ND
-
FS
D
AL
A
EK
A
I
AL
T
WRY
LP
Q
V
FNDE
-
K
D
IA
AR
T
H
M
HN
A
S
C
M
AG
M
A
F
N
S
AGLG
---
LV
H
G
MAH
A
I
G
GM
L
HI
PHG
K
I
NA
M
LLP
I
V
IDF
N
S
K
---
RAS
T
--------
ET
R
D
R
Y
HRC
A
QI
I
G
IDHAVP
E
QA
-
-
I
A
LMT
Q
E
IRQ
I
NR
HFC
IP
V
T
L
SE
L
G
I
DR
AK
I
IE
L
fig|405955.9.peg.3957
Escherichia coli APEC O1 (10-337/372)
K
I
Y
FG
EE
AI
T-
S
L
C
Q
F
---
N
N
K
RV
G
IVTD
DF
M
MSS
G
KTR
Y
L
I
S
H
M
P
E
A
S
V
--CI
F
G
E
V
T
P
D
P
D
IDI
L
TS
G
AA
R
FKAF
K
P
D
V
I
IA
L
GGGS
S
L
D
AA
K
G
I
KVTL
E
E
Y
--------
-
---
-
--
--
--
-FG
D
H--
-----------------
QID
L
I
A
I
P
TT
S
G
S
GSEVT
SY
A
I
I
S
D
PQN
G
R
K
YPLI
S
GQLV
P
EI
A
I
LD
P
NLVLT
A
P
RHVA
V
D
T
G
M
D
V
L
THAIE
A
F
V
S
TG
S
ND
-
FS
D
AL
A
EK
A
I
AL
T
WRY
LP
Q
V
FNDE
-
K
D
IA
AR
T
H
M
HN
A
S
C
M
AG
M
A
F
N
S
AGLG
---
LV
H
G
MAH
A
I
G
GM
L
HI
PHG
K
I
NA
M
LLP
I
V
IDF
N
S
K
---
RAS
T
--------
ET
R
D
R
Y
HRC
A
QI
I
G
IDHAVP
E
QA
-
-
I
A
LMT
Q
E
IRQ
I
NR
HFC
IP
V
T
L
SE
L
G
I
DR
AK
I
IE
L
fig|199310.1.peg.4427
Escherichia coli CFT073 (10-337/372)
K
I
Y
FG
EE
AI
T-
S
L
C
Q
F
---
N
N
K
RV
G
IVTD
DF
M
MSS
G
KTR
Y
L
I
S
H
M
P
E
A
S
V
--CI
F
G
E
V
T
P
D
P
D
IDI
L
TS
G
AA
R
FKAF
K
P
D
V
I
IA
L
GGGS
S
L
D
AA
K
G
I
KVTL
E
E
Y
--------
-
---
-
--
--
--
-FG
D
H--
-----------------
QID
L
I
A
I
P
TT
S
G
S
GSEVT
SY
A
I
I
S
D
PQN
G
R
K
YPLI
S
GQLV
P
EI
A
I
LD
P
NLVLT
A
P
RHVA
V
D
T
G
M
D
V
L
THAIE
A
F
V
S
TG
S
ND
-
FS
D
AL
A
EK
A
I
AL
T
WRY
LP
Q
V
FNDE
-
K
D
IA
AR
T
H
M
HN
A
S
C
M
AG
M
A
F
N
S
AGLG
---
LV
H
G
MAH
A
I
G
GM
L
HI
PHG
K
I
NA
M
LLP
I
V
IDF
N
S
K
---
RAS
T
--------
ET
R
D
R
Y
HRC
A
QI
I
G
IDHAVP
E
QA
-
-
I
A
LMT
Q
E
IRQ
I
NR
HFC
IP
V
T
L
SE
L
G
I
DR
AK
I
IE
L
fig|199310.4.peg.4250
Escherichia coli CFT073 (10-337/372)
K
I
Y
FG
EE
AI
T-
S
L
C
Q
F
---
N
N
K
RV
G
IVTD
DF
M
MSS
G
KTR
Y
L
I
S
H
M
P
E
A
S
V
--CI
F
G
E
V
T
P
D
P
D
IDI
L
TS
G
AA
R
FKAF
K
P
D
V
I
IA
L
GGGS
S
L
D
AA
K
G
I
KVTL
E
E
Y
--------
-
---
-
--
--
--
-FG
D
H--
-----------------
QID
L
I
A
I
P
TT
S
G
S
GSEVT
SY
A
I
I
S
D
PQN
G
R
K
YPLI
S
GQLV
P
EI
A
I
LD
P
NLVLT
A
P
RHVA
V
D
T
G
M
D
V
L
THAIE
A
F
V
S
TG
S
ND
-
FS
D
AL
A
EK
A
I
AL
T
WRY
LP
Q
V
FNDE
-
K
D
IA
AR
T
H
M
HN
A
S
C
M
AG
M
A
F
N
S
AGLG
---
LV
H
G
MAH
A
I
G
GM
L
HI
PHG
K
I
NA
M
LLP
I
V
IDF
N
S
K
---
RAS
T
--------
ET
R
D
R
Y
HRC
A
QI
I
G
IDHAVP
E
QA
-
-
I
A
LMT
Q
E
IRQ
I
NR
HFC
IP
V
T
L
SE
L
G
I
DR
AK
I
IE
L
fig|585397.7.peg.3455
Escherichia coli ED1a (10-337/372)
K
I
Y
FG
EE
AI
T-
S
L
C
Q
F
---
N
N
K
RV
G
IVTD
DF
M
MSS
G
KTR
Y
L
I
S
H
M
P
E
A
S
V
--CI
F
G
E
V
T
P
D
P
D
IDI
L
TS
G
AA
R
FKAF
K
P
D
V
I
IA
L
GGGS
S
L
D
AA
K
G
I
KVTL
E
E
Y
--------
-
---
-
--
--
--
-FG
D
H--
-----------------
QID
L
I
A
I
P
TT
S
G
S
GSEVT
SY
A
I
I
S
D
PQN
G
R
K
YPLI
S
GQLV
P
EI
A
I
LD
P
NLVLT
A
P
RHVA
V
D
T
G
M
D
V
L
THAIE
A
F
V
S
TG
S
ND
-
FS
D
AL
A
EK
A
I
AL
T
WRY
LP
Q
V
FNDE
-
K
D
IA
AR
T
H
M
HN
A
S
C
M
AG
M
A
F
N
S
AGLG
---
LV
H
G
MAH
A
I
G
GM
L
HI
PHG
K
I
NA
M
LLP
I
V
IDF
N
S
K
---
RAS
T
--------
ET
R
D
R
Y
HRC
A
QI
I
G
IDHAVP
E
QA
-
-
I
A
LMT
Q
E
IRQ
I
NR
HFC
IP
V
T
L
SE
L
G
I
DR
AK
I
IE
L
fig|585397.9.peg.3451
Escherichia coli ED1a (10-337/372)
K
I
Y
FG
EE
AI
T-
S
L
C
Q
F
---
N
N
K
RV
G
IVTD
DF
M
MSS
G
KTR
Y
L
I
S
H
M
P
E
A
S
V
--CI
F
G
E
V
T
P
D
P
D
IDI
L
TS
G
AA
R
FKAF
K
P
D
V
I
IA
L
GGGS
S
L
D
AA
K
G
I
KVTL
E
E
Y
--------
-
---
-
--
--
--
-FG
D
H--
-----------------
QID
L
I
A
I
P
TT
S
G
S
GSEVT
SY
A
I
I
S
D
PQN
G
R
K
YPLI
S
GQLV
P
EI
A
I
LD
P
NLVLT
A
P
RHVA
V
D
T
G
M
D
V
L
THAIE
A
F
V
S
TG
S
ND
-
FS
D
AL
A
EK
A
I
AL
T
WRY
LP
Q
V
FNDE
-
K
D
IA
AR
T
H
M
HN
A
S
C
M
AG
M
A
F
N
S
AGLG
---
LV
H
G
MAH
A
I
G
GM
L
HI
PHG
K
I
NA
M
LLP
I
V
IDF
N
S
K
---
RAS
T
--------
ET
R
D
R
Y
HRC
A
QI
I
G
IDHAVP
E
QA
-
-
I
A
LMT
Q
E
IRQ
I
NR
HFC
IP
V
T
L
SE
L
G
I
DR
AK
I
IE
L
fig|749538.3.peg.2662
Escherichia coli MS 116-1 (10-337/372)
K
I
Y
FG
EE
AI
T-
S
L
C
Q
F
---
N
N
K
RV
G
IVTD
DF
M
MSS
G
KTR
Y
L
I
S
H
M
P
E
A
S
V
--CI
F
G
E
V
T
P
D
P
D
IDI
L
TS
G
AA
R
FKAF
K
P
D
V
I
IA
L
GGGS
S
L
D
AA
K
G
I
KVTL
E
E
Y
--------
-
---
-
--
--
--
-FG
D
H--
-----------------
QID
L
I
A
I
P
TT
S
G
S
GSEVT
SY
A
I
I
S
D
PQN
G
R
K
YPLI
S
GQLV
P
EI
A
I
LD
P
NLVLT
A
P
RHVA
V
D
T
G
M
D
V
L
THAIE
A
F
V
S
TG
S
ND
-
FS
D
AL
A
EK
A
I
AL
T
WRY
LP
Q
V
FNDE
-
K
D
IA
AR
T
H
M
HN
A
S
C
M
AG
M
A
F
N
S
AGLG
---
LV
H
G
MAH
A
I
G
GM
L
HI
PHG
K
I
NA
M
LLP
I
V
IDF
N
S
K
---
RAS
T
--------
ET
R
D
R
Y
HRC
A
QI
I
G
IDHAVP
E
QA
-
-
I
A
LMT
Q
E
IRQ
I
NR
HFC
IP
V
T
L
SE
L
G
I
DR
AK
I
IE
L
fig|749527.3.peg.903
Escherichia coli MS 21-1 (10-337/372)
K
I
Y
FG
EE
AI
T-
S
L
C
Q
F
---
N
N
K
RV
G
IVTD
DF
M
MSS
G
KTR
Y
L
I
S
H
M
P
E
A
S
V
--CI
F
G
E
V
T
P
D
P
D
IDI
L
TS
G
AA
R
FKAF
K
P
D
V
I
IA
L
GGGS
S
L
D
AA
K
G
I
KVTL
E
E
Y
--------
-
---
-
--
--
--
-FG
D
H--
-----------------
QID
L
I
A
I
P
TT
S
G
S
GSEVT
SY
A
I
I
S
D
PQN
G
R
K
YPLI
S
GQLV
P
EI
A
I
LD
P
NLVLT
A
P
RHVA
V
D
T
G
M
D
V
L
THAIE
A
F
V
S
TG
S
ND
-
FS
D
AL
A
EK
A
I
AL
T
WRY
LP
Q
V
FNDE
-
K
D
IA
AR
T
H
M
HN
A
S
C
M
AG
M
A
F
N
S
AGLG
---
LV
H
G
MAH
A
I
G
GM
L
HI
PHG
K
I
NA
M
LLP
I
V
IDF
N
S
K
---
RAS
T
--------
ET
R
D
R
Y
HRC
A
QI
I
G
IDHAVP
E
QA
-
-
I
A
LMT
Q
E
IRQ
I
NR
HFC
IP
V
T
L
SE
L
G
I
DR
AK
I
IE
L
fig|362663.8.peg.1299
Escherichia coli 536 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|362663.9.peg.1299
Escherichia coli 536 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|525281.3.peg.183
Escherichia coli 83972 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|655817.3.peg.1596
Escherichia coli ABU 83972 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|405955.13.peg.1289
Escherichia coli APEC O1 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|405955.9.peg.1070
Escherichia coli APEC O1 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|199310.1.peg.1653
Escherichia coli CFT073 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|199310.4.peg.1586
Escherichia coli CFT073 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|585397.7.peg.1401
Escherichia coli ED1a (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|585397.9.peg.1394
Escherichia coli ED1a (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|340197.3.peg.1067
Escherichia coli F11 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|340197.5.peg.1125
Escherichia coli F11 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|714962.3.peg.1418
Escherichia coli IHE3034 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|656417.3.peg.1547
Escherichia coli M605 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|749546.3.peg.920
Escherichia coli MS 185-1 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|749550.3.peg.1
Escherichia coli MS 200-1 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|749528.3.peg.2506
Escherichia coli MS 45-1 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|753642.3.peg.1881
Escherichia coli NC101 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|685038.3.peg.1280
Escherichia coli O83:H1 str. NRG 857C (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|585035.6.peg.1307
Escherichia coli S88 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|431946.3.peg.1266
Escherichia coli SE15 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|656440.3.peg.1147
Escherichia coli TA206 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|869729.3.peg.2321
Escherichia coli UM146 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|364106.7.peg.1490
Escherichia coli UTI89 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|364106.8.peg.1488
Escherichia coli UTI89 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|562.376.peg.3219
Escherichia coli WV_060327 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|670897.3.peg.2174
Escherichia coli 2362-75 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
V
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|216593.1.peg.1808
Escherichia coli E2348/69 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
V
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|574521.7.peg.1401
Escherichia coli O127:H6 str. E2348/69 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DTT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
V
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|1040638.4.peg.4559
Escherichia coli O104:H4 str. LB226692 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|6666666.5357.peg.3377
Escherichia coli TY-2482 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|216592.1.peg.1670
Escherichia coli 042 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|216592.3.peg.1344
Escherichia coli 042 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|358709.5.peg.1569
Escherichia coli 101-1 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|562.371.peg.1128
Escherichia coli 1044A (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|562.373.peg.2806
Escherichia coli 1125A (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|562.372.peg.5130
Escherichia coli 1212A (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|670888.3.peg.1923
Escherichia coli 1827-70 (457-820/893)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|344610.7.peg.4911
Escherichia coli 53638 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|562.374.peg.5832
Escherichia coli 536A (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|585055.6.peg.1370
Escherichia coli 55989 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|585055.8.peg.1369
Escherichia coli 55989 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|481805.3.peg.2558
Escherichia coli ATCC 8739 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|481805.6.peg.2547
Escherichia coli ATCC 8739 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|413997.3.peg.1280
Escherichia coli B str. REL606 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|550672.3.peg.676
Escherichia coli B088 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|344601.3.peg.58
Escherichia coli B171 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|344601.5.peg.55
Escherichia coli B171 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|550676.3.peg.721
Escherichia coli B185 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|550677.3.peg.2695
Escherichia coli B354 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|340184.3.peg.1731
Escherichia coli B7A (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|340184.6.peg.1819
Escherichia coli B7A (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|511693.5.peg.1312
Escherichia coli BL21 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|469008.4.peg.2455
Escherichia coli BL21(DE3) (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|595496.3.peg.1172
Escherichia coli BW2952 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|536056.3.peg.2535
Escherichia coli DH1 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|340186.3.peg.3175
Escherichia coli E110019 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|340186.5.peg.3308
Escherichia coli E110019 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|340185.3.peg.3202
Escherichia coli E22 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|340185.4.peg.3367
Escherichia coli E22 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|331111.12.peg.1677
Escherichia coli E24377A (457-820/893)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|331111.3.peg.3849
Escherichia coli E24377A (457-820/893)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|562.375.peg.4136
Escherichia coli EC4100B (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|316401.4.peg.1551
Escherichia coli ETEC H10407 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|656379.3.peg.3330
Escherichia coli FVEC1302 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|656380.3.peg.2685
Escherichia coli FVEC1412 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|656393.3.peg.2002
Escherichia coli H299 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|656408.3.peg.1310
Escherichia coli H591 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|656414.3.peg.1474
Escherichia coli H736 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|331112.3.peg.1261
Escherichia coli HS (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|331112.6.peg.1315
Escherichia coli HS (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|585034.4.peg.1250
Escherichia coli IAI1 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|585034.5.peg.1246
Escherichia coli IAI1 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|585057.4.peg.1647
Escherichia coli IAI39 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|585057.6.peg.1647
Escherichia coli IAI39 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|83333.1.peg.1228
Escherichia coli K12 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|595495.4.peg.1152
Escherichia coli KO11 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|656419.3.peg.1578
Escherichia coli M718 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|679207.4.peg.4603
Escherichia coli MS 107-1 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|749537.3.peg.3288
Escherichia coli MS 115-1 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|749538.3.peg.4968
Escherichia coli MS 116-1 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|679206.4.peg.763
Escherichia coli MS 119-7 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|679205.4.peg.3282
Escherichia coli MS 124-1 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|679204.3.peg.1478
Escherichia coli MS 145-7 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|749540.3.peg.3643
Escherichia coli MS 146-1 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|749544.3.peg.1673
Escherichia coli MS 175-1 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|749545.3.peg.4389
Escherichia coli MS 182-1 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|749547.3.peg.115
Escherichia coli MS 187-1 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|749548.3.peg.3834
Escherichia coli MS 196-1 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|749549.3.peg.418
Escherichia coli MS 198-1 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|749527.3.peg.2332
Escherichia coli MS 21-1 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|749531.3.peg.4150
Escherichia coli MS 69-1 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|749532.3.peg.1861
Escherichia coli MS 78-1 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|585395.4.peg.1409
Escherichia coli O103:H2 str. 12009 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|585396.4.peg.1631
Escherichia coli O111:H- str. 11128 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|83334.1.peg.1786
Escherichia coli O157:H7 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|444454.5.peg.6208
Escherichia coli O157:H7 str. EC4024 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|444449.5.peg.5057
Escherichia coli O157:H7 str. EC4042 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|444448.5.peg.4320
Escherichia coli O157:H7 str. EC4045 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|444453.5.peg.5389
Escherichia coli O157:H7 str. EC4076 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|444452.5.peg.3712
Escherichia coli O157:H7 str. EC4113 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|444450.8.peg.1782
Escherichia coli O157:H7 str. EC4115 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|444451.5.peg.4347
Escherichia coli O157:H7 str. EC4196 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|444447.5.peg.4569
Escherichia coli O157:H7 str. EC4206 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|478004.5.peg.4763
Escherichia coli O157:H7 str. EC4401 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|478005.5.peg.4797
Escherichia coli O157:H7 str. EC4486 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|478006.5.peg.4666
Escherichia coli O157:H7 str. EC4501 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|478007.5.peg.4158
Escherichia coli O157:H7 str. EC508 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|478008.5.peg.2955
Escherichia coli O157:H7 str. EC869 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|637388.3.peg.2084
Escherichia coli O157:H7 str. FRIK2000 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|570506.3.peg.3055
Escherichia coli O157:H7 str. FRIK966 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|386585.9.peg.1842
Escherichia coli O157:H7 str. Sakai (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|544404.4.peg.1643
Escherichia coli O157:H7 str. TW14359 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|502346.5.peg.2549
Escherichia coli O157:H7 str. TW14588 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|573235.3.peg.1783
Escherichia coli O26:H11 str. 11368 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|701177.3.peg.1498
Escherichia coli O55:H7 str. CB9615 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|409438.11.peg.1425
Escherichia coli SE11 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|439855.10.peg.2060
Escherichia coli SMS-3-5 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|656437.3.peg.1382
Escherichia coli TA143 (457-820/893)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|656443.3.peg.1568
Escherichia coli TA271 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|656444.3.peg.1958
Escherichia coli TA280 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|585056.7.peg.1735
Escherichia coli UMN026 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|566546.3.peg.267
Escherichia coli W (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|566546.4.peg.1326
Escherichia coli W (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|316407.3.peg.1201
Escherichia coli W3110 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|316385.5.peg.1296
Escherichia coli str. K-12 substr. DH10B (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|316385.7.peg.1322
Escherichia coli str. K-12 substr. DH10B (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|511145.12.peg.1290
Escherichia coli str. K-12 substr. MG1655 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|511145.6.peg.1278
Escherichia coli str. K-12 substr. MG1655 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
A
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|155864.1.peg.1792
Escherichia coli O157:H7 EDL933 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
X
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|155864.8.peg.1596
Escherichia coli O157:H7 EDL933 (457-820/891)
PK
S
I
Y
F
R
RG
S
L
PI
A
L
DEV
ITD
G
H
K
RA
LIVTD
RF
L
FNN
G
YAD
Q
I
T
S
V
L
K
AAGV
ETEV
F
F
E
VE
AD
PT
LSI
V
RK
G
AE
L
ANSF
K
P
D
V
I
IA
L
GGGSP
M
D
AA
K
I
M
WVMY
E
H
P
--------
-
---
-
--
--
E
T
HFE
E
LAL
RFMDIRKRIYKFPKMGV
KAK
M
I
AV
T
TT
S
GTGSEVT
PF
AV
V
TD
DAT
G
Q
K
YPLA
D
YALT
P
DM
A
I
V
DA
NLVMD
MP
KSLC
A
F
GG
L
DA
V
THA
M
E
A
YV
S
VL
A
SE
-
FS
D
GQ
A
LQ
AL
KL
L
KEY
LP
A
S
YHEG
S
K
N
PV
ARE
R
V
HS
A
X
T
I
AG
I
A
F
A
NA
F
LG
---
VC
H
S
MAH
K
LG
SQ
F
HI
PHG
L
ANA
L
L
IC
N
V
IRY
NA
N
DNPTKQTAFSQYDRP
QA
R
R
R
Y
AEI
A
DH
LG
LSAPGD
R
TA
A
K
I
E
KL
L
A
W
LET
L
KA
E
LGIP
K
S
I
R
E
A
GV
fig|749531.3.peg.4028
Escherichia coli MS 69-1 (6-347/385)
S
T
IL
S
G
A
GAI
PS
L
T
SL
L
P--
D
I
R
KM
L
L
VTD
RN
I
AQL
D
GVQ
Q
I
R
A
L
L
E
KHCP
QVNV
I
D
N
V
P
A
E
PT
HHD
V
RQ
L
MD
A
PGDA
S
F
D
V
VV
G
IGGGS
V
L
D
VA
K
L
L
SVLC
H
P
Q
SPGLDAL
L
A
GEK
P
TQ
--
--
---
-
---
-----------------
RVQ
S
W
L
I
P
TT
A
GTGSE
A
T
PN
A
IL
AI
PEQ
S
T
K
VGII
S
PVLL
P
DY
V
A
L
F
P
ELTTS
MP
AHIA
A
S
T
G
I
DA
L
C
H
L
L
E
C
F
TA
TV
A
NP
-
VS
D
NA
A
LT
G
L
SK
L
FRH
I
Q
P
A
VNDP
-
Q
D
LR
A
K
L
E
M
LW
A
S
Y
Y
G
G
V
A
I
T
H
AG
TH
---
LV
H
A
L
SY
P
LG
GK
Y
HL
PHG
V
ANAILL
A
P
C
MAF
V
R
P
---------------
WA
V
E
K
F
ARV
W
DC
I
P
DAETAL
S
AE
E
K
S
H
A
L
V
A
W
LQA
L
VN
QL
K
L
P
N
N
L
A
D
L
GV
PP
EDI
AS
L
fig|670897.3.peg.836
Escherichia coli 2362-75 (6-347/385)
S
T
IL
S
G
A
GAI
PS
L
T
SL
L
P--
D
I
R
KM
L
L
VTD
RN
I
AQL
D
GVQ
Q
I
R
A
L
L
E
QHCP
QVNV
I
D
N
V
P
A
E
PT
HHD
V
RQ
L
MD
V
LGDA
S
F
D
V
VV
G
IGGGS
V
L
D
VA
K
L
L
SVLC
H
P
Q
SPGLDAL
L
A
GEK
P
TQ
--
--
---
-
---
-----------------
RVQ
S
W
L
I
P
TT
A
GTGSE
A
T
PN
A
IL
AI
PEQ
S
T
K
VGII
S
QMLL
P
DY
V
A
L
F
P
ELTTS
MP
AHIA
A
S
T
G
I
DA
L
C
H
L
L
E
C
F
TA
TV
A
NP
-
VS
D
NA
A
LT
G
L
SK
L
FRH
I
Q
P
A
VNDP
-
Q
D
LR
A
K
L
E
M
LW
A
S
Y
Y
G
G
V
A
I
T
H
AG
TH
---
LV
H
A
L
SY
P
LG
GK
Y
HL
PHG
V
ANAILL
A
P
C
MAF
V
R
P
---------------
WA
V
E
K
F
ARV
W
DC
I
P
DAETAL
S
AE
E
K
S
H
A
L
V
T
W
LQA
L
VN
QL
K
L
P
N
N
L
A
D
L
GV
PP
EDI
AS
L
fig|216593.1.peg.2945
Escherichia coli E2348/69 (6-347/385)
S
T
IL
S
G
A
GAI
PS
L
T
SL
L
P--
D
I
R
KM
L
L
VTD
RN
I
AQL
D
GVQ
Q
I
R
A
L
L
E
QHCP
QVNV
I
D
N
V
P
A
E
PT
HHD
V
RQ
L
MD
V
LGDA
S
F
D
V
VV
G
IGGGS
V
L
D
VA
K
L
L
SVLC
H
P
Q
SPGLDAL
L
A
GEK
P
TQ
--
--
---
-
---
-----------------
RVQ
S
W
L
I
P
TT
A
GTGSE
A
T
PN
A
IL
AI
PEQ
S
T
K
VGII
S
QMLL
P
DY
V
A
L
F
P
ELTTS
MP
AHIA
A
S
T
G
I
DA
L
C
H
L
L
E
C
F
TA
TV
A
NP
-
VS
D
NA
A
LT
G
L
SK
L
FRH
I
Q
P
A
VNDP
-
Q
D
LR
A
K
L
E
M
LW
A
S
Y
Y
G
G
V
A
I
T
H
AG
TH
---
LV
H
A
L
SY
P
LG
GK
Y
HL
PHG
V
ANAILL
A
P
C
MAF
V
R
P
---------------
WA
V
E
K
F
ARV
W
DC
I
P
DAETAL
S
AE
E
K
S
H
A
L
V
T
W
LQA
L
VN
QL
K
L
P
N
N
L
A
D
L
GV
PP
EDI
AS
L
fig|574521.7.peg.609
Escherichia coli O127:H6 str. E2348/69 (6-347/385)
S
T
IL
S
G
A
GAI
PS
L
T
SL
L
P--
D
I
R
KM
L
L
VTD
RN
I
AQL
D
GVQ
Q
I
R
A
L
L
E
QHCP
QVNV
I
D
N
V
P
A
E
PT
HHD
V
RQ
L
MD
V
LGDA
S
F
D
V
VV
G
IGGGS
V
L
D
VA
K
L
L
SVLC
H
P
Q
SPGLDAL
L
A
GEK
P
TQ
--
--
---
-
---
-----------------
RVQ
S
W
L
I
P
TT
A
GTGSE
A
T
PN
A
IL
AI
PEQ
S
T
K
VGII
S
QMLL
P
DY
V
A
L
F
P
ELTTS
MP
AHIA
A
S
T
G
I
DA
L
C
H
L
L
E
C
F
TA
TV
A
NP
-
VS
D
NA
A
LT
G
L
SK
L
FRH
I
Q
P
A
VNDP
-
Q
D
LR
A
K
L
E
M
LW
A
S
Y
Y
G
G
V
A
I
T
H
AG
TH
---
LV
H
A
L
SY
P
LG
GK
Y
HL
PHG
V
ANAILL
A
P
C
MAF
V
R
P
---------------
WA
V
E
K
F
ARV
W
DC
I
P
DAETAL
S
AE
E
K
S
H
A
L
V
T
W
LQA
L
VN
QL
K
L
P
N
N
L
A
D
L
GV
PP
EDI
AS
L
fig|362663.8.peg.706
Escherichia coli 536 (6-347/385)
S
T
IL
S
G
A
GAI
PS
L
T
SL
L
P--
D
I
R
KM
L
L
VTD
RN
I
AQL
D
GVQ
Q
I
R
A
L
L
E
KHCP
QVNV
I
D
N
V
P
A
E
PT
HHD
V
RQ
L
MD
A
LGDA
S
F
D
V
VV
G
IGGGS
V
L
D
VA
K
L
L
SVLC
H
P
Q
SPGLDAL
L
A
GEK
P
TQ
--
--
---
-
---
-----------------
RVQ
S
W
L
I
P
TT
A
GTGSE
A
T
PN
A
IL
AI
PEQ
S
T
K
VGII
S
QVLL
P
DY
V
A
L
F
P
ELTTS
MP
AHIA
A
S
T
G
I
DA
L
C
H
L
L
E
C
F
TA
TV
A
NP
-
VS
D
NV
A
LT
G
L
SK
L
FRH
I
Q
P
A
VNDP
-
Q
D
LR
A
K
L
E
M
LW
A
S
Y
Y
G
G
V
A
I
T
H
AG
TH
---
LV
H
A
L
SY
P
LG
GK
Y
HL
PHG
V
ANAILL
A
P
C
MAF
V
R
P
---------------
WA
V
E
K
F
ARV
W
DC
I
P
DAETAL
S
TE
E
K
S
H
A
L
V
T
W
LQA
L
VH
QL
K
L
P
N
N
L
A
D
L
GV
PP
EDI
AS
L
fig|362663.9.peg.706
Escherichia coli 536 (6-347/385)
S
T
IL
S
G
A
GAI
PS
L
T
SL
L
P--
D
I
R
KM
L
L
VTD
RN
I
AQL
D
GVQ
Q
I
R
A
L
L
E
KHCP
QVNV
I
D
N
V
P
A
E
PT
HHD
V
RQ
L
MD
A
LGDA
S
F
D
V
VV
G
IGGGS
V
L
D
VA
K
L
L
SVLC
H
P
Q
SPGLDAL
L
A
GEK
P
TQ
--
--
---
-
---
-----------------
RVQ
S
W
L
I
P
TT
A
GTGSE
A
T
PN
A
IL
AI
PEQ
S
T
K
VGII
S
QVLL
P
DY
V
A
L
F
P
ELTTS
MP
AHIA
A
S
T
G
I
DA
L
C
H
L
L
E
C
F
TA
TV
A
NP
-
VS
D
NV
A
LT
G
L
SK
L
FRH
I
Q
P
A
VNDP
-
Q
D
LR
A
K
L
E
M
LW
A
S
Y
Y
G
G
V
A
I
T
H
AG
TH
---
LV
H
A
L
SY
P
LG
GK
Y
HL
PHG
V
ANAILL
A
P
C
MAF
V
R
P
---------------
WA
V
E
K
F
ARV
W
DC
I
P
DAETAL
S
TE
E
K
S
H
A
L
V
T
W
LQA
L
VH
QL
K
L
P
N
N
L
A
D
L
GV
PP
EDI
AS
L
fig|340197.3.peg.4092
Escherichia coli F11 (6-347/385)
S
T
IL
S
G
A
GAI
PS
L
T
SL
L
P--
D
I
R
KM
L
L
VTD
RN
I
AQL
D
GVQ
Q
I
R
A
L
L
E
KHCP
QVNV
I
D
N
V
P
A
E
PT
HHD
V
RQ
L
MD
A
LGDA
S
F
D
V
VV
G
IGGGS
V
L
D
VA
K
L
L
SVLC
H
P
Q
SPGLDAL
L
A
GEK
P
TQ
--
--
---
-
---
-----------------
RVQ
S
W
L
I
P
TT
A
GTGSE
A
T
PN
A
IL
AI
PEQ
S
T
K
VGII
S
QVLL
P
DY
V
A
L
F
P
ELTTS
MP
AHIA
A
S
T
G
I
DA
L
C
H
L
L
E
C
F
TA
TV
A
NP
-
VS
D
NV
A
LT
G
L
SK
L
FRH
I
Q
P
A
VNDP
-
Q
D
LR
A
K
L
E
M
LW
A
S
Y
Y
G
G
V
A
I
T
H
AG
TH
---
LV
H
A
L
SY
P
LG
GK
Y
HL
PHG
V
ANAILL
A
P
C
MAF
V
R
P
---------------
WA
V
E
K
F
ARV
W
DC
I
P
DAETAL
S
TE
E
K
S
H
A
L
V
T
W
LQA
L
VH
QL
K
L
P
N
N
L
A
D
L
GV
PP
EDI
AS
L
fig|340197.5.peg.4267
Escherichia coli F11 (6-347/385)
S
T
IL
S
G
A
GAI
PS
L
T
SL
L
P--
D
I
R
KM
L
L
VTD
RN
I
AQL
D
GVQ
Q
I
R
A
L
L
E
KHCP
QVNV
I
D
N
V
P
A
E
PT
HHD
V
RQ
L
MD
A
LGDA
S
F
D
V
VV
G
IGGGS
V
L
D
VA
K
L
L
SVLC
H
P
Q
SPGLDAL
L
A
GEK
P
TQ
--
--
---
-
---
-----------------
RVQ
S
W
L
I
P
TT
A
GTGSE
A
T
PN
A
IL
AI
PEQ
S
T
K
VGII
S
QVLL
P
DY
V
A
L
F
P
ELTTS
MP
AHIA
A
S
T
G
I
DA
L
C
H
L
L
E
C
F
TA
TV
A
NP
-
VS
D
NV
A
LT
G
L
SK
L
FRH
I
Q
P
A
VNDP
-
Q
D
LR
A
K
L
E
M
LW
A
S
Y
Y
G
G
V
A
I
T
H
AG
TH
---
LV
H
A
L
SY
P
LG
GK
Y
HL
PHG
V
ANAILL
A
P
C
MAF
V
R
P
---------------
WA
V
E
K
F
ARV
W
DC
I
P
DAETAL
S
TE
E
K
S
H
A
L
V
T
W
LQA
L
VH
QL
K
L
P
N
N
L
A
D
L
GV
PP
EDI
AS
L
fig|749550.3.peg.4773
Escherichia coli MS 200-1 (6-347/385)
S
T
IL
S
G
A
GAI
PS
L
T
SL
L
P--
D
I
R
KM
L
L
VTD
RN
I
AQL
D
GVQ
Q
I
R
A
L
L
E
KHCP
QVNV
I
D
N
V
P
A
E
PT
HHD
V
RQ
L
MD
A
LGDA
S
F
D
V
VV
G
IGGGS
V
L
D
VA
K
L
L
SVLC
H
P
Q
SPGLDAL
L
A
GEK
P
TQ
--
--
---
-
---
-----------------
RVQ
S
W
L
I
P
TT
A
GTGSE
A
T
PN
A
IL
AI
PEQ
S
T
K
VGII
S
QVLL
P
DY
V
A
L
F
P
ELTTS
MP
AHIA
A
S
T
G
I
DA
L
C
H
L
L
E
C
F
TA
TV
A
NP
-
VS
D
NV
A
LT
G
L
SK
L
FRH
I
Q
P
A
VNDP
-
Q
D
LR
A
K
L
E
M
LW
A
S
Y
Y
G
G
V
A
I
T
H
AG
TH
---
LV
H
A
L
SY
P
LG
GK
Y
HL
PHG
V
ANAILL
A
P
C
MAF
V
R
P
---------------
WA
V
E
K
F
ARV
W
DC
I
P
DAETAL
S
TE
E
K
S
H
A
L
V
T
W
LQA
L
VH
QL
K
L
P
N
N
L
A
D
L
GV
PP
EDI
AS
L
fig|405955.13.peg.649
Escherichia coli APEC O1 (6-347/385)
S
T
IL
S
G
A
GAI
PS
L
T
SL
L
P--
D
I
R
KM
L
L
VTD
RN
I
AQL
D
GVQ
Q
I
R
A
L
L
E
KHCP
QVNV
I
D
N
V
P
A
E
PT
HHD
V
RQ
L
MD
A
LGDA
S
F
D
V
VV
G
IGGGS
V
L
D
VA
K
L
L
SVLC
H
P
Q
SPGLDAL
L
A
GEK
P
TQ
--
--
---
-
---
-----------------
RVQ
S
W
L
I
P
TT
A
GTGSE
A
T
PN
A
IL
AI
PEQ
S
T
K
VGII
S
QVLL
P
DY
V
A
L
F
P
ELTTS
MP
AHIA
A
S
T
G
I
DA
L
C
H
L
L
E
C
F
TA
TV
A
NP
-
VS
D
NA
A
LT
G
L
SK
L
FRH
I
Q
P
A
VNDP
-
Q
D
LR
A
K
L
E
M
LW
A
S
Y
Y
G
G
V
A
I
T
H
AG
TH
---
LV
H
A
L
SY
P
LG
GK
Y
HL
PHG
V
ANAILL
A
P
C
MAF
V
R
P
---------------
WA
V
E
K
F
ARV
W
DC
I
P
DAETAL
S
AE
E
K
S
H
A
L
V
T
W
LQA
L
VN
QL
K
L
P
N
N
L
A
D
L
GV
PP
EDI
AS
L
fig|405955.9.peg.538
Escherichia coli APEC O1 (6-347/385)
S
T
IL
S
G
A
GAI
PS
L
T
SL
L
P--
D
I
R
KM
L
L
VTD
RN
I
AQL
D
GVQ
Q
I
R
A
L
L
E
KHCP
QVNV
I
D
N
V
P
A
E
PT
HHD
V
RQ
L
MD
A
LGDA
S
F
D
V
VV
G
IGGGS
V
L
D
VA
K
L
L
SVLC
H
P
Q
SPGLDAL
L
A
GEK
P
TQ
--
--
---
-
---
-----------------
RVQ
S
W
L
I
P
TT
A
GTGSE
A
T
PN
A
IL
AI
PEQ
S
T
K
VGII
S
QVLL
P
DY
V
A
L
F
P
ELTTS
MP
AHIA
A
S
T
G
I
DA
L
C
H
L
L
E
C
F
TA
TV
A
NP
-
VS
D
NA
A
LT
G
L
SK
L
FRH
I
Q
P
A
VNDP
-
Q
D
LR
A
K
L
E
M
LW
A
S
Y
Y
G
G
V
A
I
T
H
AG
TH
---
LV
H
A
L
SY
P
LG
GK
Y
HL
PHG
V
ANAILL
A
P
C
MAF
V
R
P
---------------
WA
V
E
K
F
ARV
W
DC
I
P
DAETAL
S
AE
E
K
S
H
A
L
V
T
W
LQA
L
VN
QL
K
L
P
N
N
L
A
D
L
GV
PP
EDI
AS
L
fig|714962.3.peg.698
Escherichia coli IHE3034 (6-347/385)
S
T
IL
S
G
A
GAI
PS
L
T
SL
L
P--
D
I
R
KM
L
L
VTD
RN
I
AQL
D
GVQ
Q
I
R
A
L
L
E
KHCP
QVNV
I
D
N
V
P
A
E
PT
HHD
V
RQ
L
MD
A
LGDA
S
F
D
V
VV
G
IGGGS
V
L
D
VA
K
L
L
SVLC
H
P
Q
SPGLDAL
L
A
GEK
P
TQ
--
--
---
-
---
-----------------
RVQ
S
W
L
I
P
TT
A
GTGSE
A
T
PN
A
IL
AI
PEQ
S
T
K
VGII
S
QVLL
P
DY
V
A
L
F
P
ELTTS
MP
AHIA
A
S
T
G
I
DA
L
C
H
L
L
E
C
F
TA
TV
A
NP
-
VS
D
NA
A
LT
G
L
SK
L
FRH
I
Q
P
A
VNDP
-
Q
D
LR
A
K
L
E
M
LW
A
S
Y
Y
G
G
V
A
I
T
H
AG
TH
---
LV
H
A
L
SY
P
LG
GK
Y
HL
PHG
V
ANAILL
A
P
C
MAF
V
R
P
---------------
WA
V
E
K
F
ARV
W
DC
I
P
DAETAL
S
AE
E
K
S
H
A
L
V
T
W
LQA
L
VN
QL
K
L
P
N
N
L
A
D
L
GV
PP
EDI
AS
L
fig|869729.3.peg.3029
Escherichia coli UM146 (6-347/385)
S
T
IL
S
G
A
GAI
PS
L
T
SL
L
P--
D
I
R
KM
L
L
VTD
RN
I
AQL
D
GVQ
Q
I
R
A
L
L
E
KHCP
QVNV
I
D
N
V
P
A
E
PT
HHD
V
RQ
L
MD
A
LGDA
S
F
D
V
VV
G
IGGGS
V
L
D
VA
K
L
L
SVLC
H
P
Q
SPGLDAL
L
A
GEK
P
TQ
--
--
---
-
---
-----------------
RVQ
S
W
L
I
P
TT
A
GTGSE
A
T
PN
A
IL
AI
PEQ
S
T
K
VGII
S
QVLL
P
DY
V
A
L
F
P
ELTTS
MP
AHIA
A
S
T
G
I
DA
L
C
H
L
L
E
C
F
TA
TV
A
NP
-
VS
D
NA
A
LT
G
L
SK
L
FRH
I
Q
P
A
VNDP
-
Q
D
LR
A
K
L
E
M
LW
A
S
Y
Y
G
G
V
A
I
T
H
AG
TH
---
LV
H
A
L
SY
P
LG
GK
Y
HL
PHG
V
ANAILL
A
P
C
MAF
V
R
P
---------------
WA
V
E
K
F
ARV
W
DC
I
P
DAETAL
S
AE
E
K
S
H
A
L
V
T
W
LQA
L
VN
QL
K
L
P
N
N
L
A
D
L
GV
PP
EDI
AS
L
fig|364106.7.peg.778
Escherichia coli UTI89 (6-347/385)
S
T
IL
S
G
A
GAI
PS
L
T
SL
L
P--
D
I
R
KM
L
L
VTD
RN
I
AQL
D
GVQ
Q
I
R
A
L
L
E
KHCP
QVNV
I
D
N
V
P
A
E
PT
HHD
V
RQ
L
MD
A
LGDA
S
F
D
V
VV
G
IGGGS
V
L
D
VA
K
L
L
SVLC
H
P
Q
SPGLDAL
L
A
GEK
P
TQ
--
--
---
-
---
-----------------
RVQ
S
W
L
I
P
TT
A
GTGSE
A
T
PN
A
IL
AI
PEQ
S
T
K
VGII
S
QVLL
P
DY
V
A
L
F
P
ELTTS
MP
AHIA
A
S
T
G
I
DA
L
C
H
L
L
E
C
F
TA
TV
A
NP
-
VS
D
NA
A
LT
G
L
SK
L
FRH
I
Q
P
A
VNDP
-
Q
D
LR
A
K
L
E
M
LW
A
S
Y
Y
G
G
V
A
I
T
H
AG
TH
---
LV
H
A
L
SY
P
LG
GK
Y
HL
PHG
V
ANAILL
A
P
C
MAF
V
R
P
---------------
WA
V
E
K
F
ARV
W
DC
I
P
DAETAL
S
AE
E
K
S
H
A
L
V
T
W
LQA
L
VN
QL
K
L
P
N
N
L
A
D
L
GV
PP
EDI
AS
L
fig|364106.8.peg.776
Escherichia coli UTI89 (6-347/385)
S
T
IL
S
G
A
GAI
PS
L
T
SL
L
P--
D
I
R
KM
L
L
VTD
RN
I
AQL
D
GVQ
Q
I
R
A
L
L
E
KHCP
QVNV
I
D
N
V
P
A
E
PT
HHD
V
RQ
L
MD
A
LGDA
S
F
D
V
VV
G
IGGGS
V
L
D
VA
K
L
L
SVLC
H
P
Q
SPGLDAL
L
A
GEK
P
TQ
--
--
---
-
---
-----------------
RVQ
S
W
L
I
P
TT
A
GTGSE
A
T
PN
A
IL
AI
PEQ
S
T
K
VGII
S
QVLL
P
DY
V
A
L
F
P
ELTTS
MP
AHIA
A
S
T
G
I
DA
L
C
H
L
L
E
C
F
TA
TV
A
NP
-
VS
D
NA
A
LT
G
L
SK
L
FRH
I
Q
P
A
VNDP
-
Q
D
LR
A
K
L
E
M
LW
A
S
Y
Y
G
G
V
A
I
T
H
AG
TH
---
LV
H
A
L
SY
P
LG
GK
Y
HL
PHG
V
ANAILL
A
P
C
MAF
V
R
P
---------------
WA
V
E
K
F
ARV
W
DC
I
P
DAETAL
S
AE
E
K
S
H
A
L
V
T
W
LQA
L
VN
QL
K
L
P
N
N
L
A
D
L
GV
PP
EDI
AS
L
fig|656417.3.peg.805
Escherichia coli M605 (6-347/385)
S
T
IL
S
G
A
GAI
PS
L
T
SL
L
P--
D
I
R
KM
L
L
VTD
RN
I
AQL
D
GVQ
Q
I
R
A
L
L
E
KHCP
QVNV
I
D
N
V
P
A
E
PT
HHD
V
RQ
L
MD
A
LGDA
S
F
D
V
VV
G
IGGGS
V
L
D
VA
K
L
L
SVLC
H
P
Q
SPGLDAL
L
A
GEK
P
TQ
--
--
---
-
---
-----------------
RVQ
S
W
L
I
P
TT
A
GTGSE
A
T
PN
A
IL
AI
PEQ
S
T
K
VGII
S
QVLL
P
DY
V
A
L
F
P
ELTTS
MP
AHIA
A
S
T
G
I
DA
L
C
H
L
L
E
C
F
TA
TV
A
NP
-
VS
D
NA
A
LT
G
L
SK
L
FRH
I
Q
P
A
VNDP
-
Q
D
LR
A
K
L
E
M
LW
A
S
Y
Y
G
G
V
A
I
T
H
AG
TH
---
LV
H
A
L
SY
P
LG
GK
Y
HL
PHG
V
ANAILL
A
P
C
MAF
V
R
P
---------------
WA
V
E
K
F
AQV
W
DC
I
P
DAETAL
S
AE
E
K
S
H
A
L
V
T
W
LQA
L
VN
QL
K
L
P
N
N
L
A
D
L
GV
PP
EDI
AS
L
fig|431946.3.peg.640
Escherichia coli SE15 (6-347/385)
S
T
IL
S
G
A
GAI
PS
L
T
SL
L
P--
D
I
R
KM
L
L
VTD
RN
I
AQL
D
GVQ
Q
I
R
A
L
L
E
KHCP
QVNV
I
D
N
V
P
A
E
PT
HHD
V
RQ
L
MD
A
LGDA
S
F
D
V
VV
G
IGGGS
V
L
D
VA
K
L
L
SVLC
H
P
Q
SPGLDAL
L
A
GEK
P
TQ
--
--
---
-
---
-----------------
RVQ
S
W
L
I
P
TT
A
GTGSE
A
T
PN
A
IL
AI
PEQ
S
T
K
VGII
S
QVLL
P
DY
V
A
L
F
P
ELTTS
MP
AHIA
A
S
T
G
I
DA
L
C
H
L
L
E
C
F
TA
TV
A
NP
-
VS
D
NA
A
LT
G
L
SK
L
FRH
I
Q
P
A
VNDP
-
Q
D
LR
A
K
L
E
M
LW
A
S
Y
Y
G
G
V
A
I
T
H
AG
TH
---
LV
H
A
L
SY
P
LG
GK
Y
HL
PHG
V
ANAILL
A
P
C
MAF
V
R
P
---------------
WA
V
E
K
F
AQV
W
DC
I
P
DAETAL
S
AE
E
K
S
H
A
L
V
T
W
LQA
L
VN
QL
K
L
P
N
N
L
A
D
L
GV
PP
EDI
AS
L
fig|753642.3.peg.981
Escherichia coli NC101 (6-347/385)
S
T
IL
S
G
A
GAI
PS
L
T
SL
L
P--
D
I
R
KM
L
L
VTD
RN
I
AQL
D
GVQ
Q
I
R
A
L
L
E
KHCP
QVNV
I
D
N
V
P
A
E
PT
HHN
V
RQ
L
MD
V
LGDA
S
F
D
V
VV
G
IGGGS
V
L
D
VA
K
L
L
SVLC
H
P
Q
SPGLDAL
L
A
GEK
P
TQ
--
--
---
-
---
-----------------
RVQ
S
W
L
I
P
TT
A
GTGSE
A
T
PN
A
IL
AI
PEQ
S
T
K
VGII
S
QVLL
P
DY
V
A
L
F
P
ELTTS
MP
AHIA
A
S
T
G
I
DA
L
C
H
L
L
E
C
F
TA
TV
A
NP
-
VS
D
NA
A
LT
G
L
SK
L
FRH
I
Q
P
A
VNDP
-
Q
D
LR
A
K
L
E
M
LW
A
S
Y
Y
G
G
V
A
I
T
H
AG
TH
---
LV
H
A
L
SY
P
LG
GK
Y
HL
PHG
V
ANAILL
A
P
C
MAF
V
R
P
---------------
WA
V
E
K
F
ARV
W
DC
I
P
DAETAL
S
AE
E
K
S
H
A
L
V
T
W
LQA
L
VN
QL
K
L
P
N
N
L
AA
L
GV
PP
EDI
AS
L
fig|525281.3.peg.2267
Escherichia coli 83972 (6-347/385)
S
T
IL
S
G
A
GAI
PS
L
T
SL
L
P--
D
I
R
KM
L
L
VTD
RN
I
AQL
D
GVQ
Q
I
R
A
L
L
E
KHCP
QVNV
I
D
N
V
P
A
E
PT
HHD
V
RQ
L
MD
A
PGDA
S
F
D
V
VV
G
IGGGS
V
L
D
VA
K
L
L
SVLC
H
P
Q
SPGLDAL
L
A
GEK
P
TQ
--
--
---
-
---
-----------------
RVQ
S
W
L
I
P
TT
A
GTGSE
A
T
PN
A
IL
AI
PEQ
S
T
K
VGII
S
QVLL
P
DY
V
A
L
F
P
ELTTS
MP
AHIA
A
S
T
G
I
DA
L
C
H
L
L
E
C
F
TA
TV
A
NP
-
VS
D
NA
A
LT
G
L
SK
L
FRH
I
Q
P
A
VNDP
-
Q
D
LR
A
K
L
E
M
LW
A
S
Y
Y
G
G
V
A
I
T
H
AG
TH
---
LV
H
A
L
SY
P
LG
GK
Y
HL
PHG
V
ANAILL
A
P
C
MAF
V
R
P
---------------
WA
V
E
K
F
ARV
W
DC
I
P
DAETAL
S
AE
E
K
S
H
A
L
V
T
W
LQA
L
VN
QL
K
L
P
N
N
L
AA
L
GV
PP
EDI
AS
L
fig|655817.3.peg.767
Escherichia coli ABU 83972 (6-347/385)
S
T
IL
S
G
A
GAI
PS
L
T
SL
L
P--
D
I
R
KM
L
L
VTD
RN
I
AQL
D
GVQ
Q
I
R
A
L
L
E
KHCP
QVNV
I
D
N
V
P
A
E
PT
HHD
V
RQ
L
MD
A
PGDA
S
F
D
V
VV
G
IGGGS
V
L
D
VA
K
L
L
SVLC
H
P
Q
SPGLDAL
L
A
GEK
P
TQ
--
--
---
-
---
-----------------
RVQ
S
W
L
I
P
TT
A
GTGSE
A
T
PN
A
IL
AI
PEQ
S
T
K
VGII
S
QVLL
P
DY
V
A
L
F
P
ELTTS
MP
AHIA
A
S
T
G
I
DA
L
C
H
L
L
E
C
F
TA
TV
A
NP
-
VS
D
NA
A
LT
G
L
SK
L
FRH
I
Q
P
A
VNDP
-
Q
D
LR
A
K
L
E
M
LW
A
S
Y
Y
G
G
V
A
I
T
H
AG
TH
---
LV
H
A
L
SY
P
LG
GK
Y
HL
PHG
V
ANAILL
A
P
C
MAF
V
R
P
---------------
WA
V
E
K
F
ARV
W
DC
I
P
DAETAL
S
AE
E
K
S
H
A
L
V
T
W
LQA
L
VN
QL
K
L
P
N
N
L
AA
L
GV
PP
EDI
AS
L
fig|199310.1.peg.735
Escherichia coli CFT073 (6-347/385)
S
T
IL
S
G
A
GAI
PS
L
T
SL
L
P--
D
I
R
KM
L
L
VTD
RN
I
AQL
D
GVQ
Q
I
R
A
L
L
E
KHCP
QVNV
I
D
N
V
P
A
E
PT
HHD
V
RQ
L
MD
A
PGDA
S
F
D
V
VV
G
IGGGS
V
L
D
VA
K
L
L
SVLC
H
P
Q
SPGLDAL
L
A
GEK
P
TQ
--
--
---
-
---
-----------------
RVQ
S
W
L
I
P
TT
A
GTGSE
A
T
PN
A
IL
AI
PEQ
S
T
K
VGII
S
QVLL
P
DY
V
A
L
F
P
ELTTS
MP
AHIA
A
S
T
G
I
DA
L
C
H
L
L
E
C
F
TA
TV
A
NP
-
VS
D
NA
A
LT
G
L
SK
L
FRH
I
Q
P
A
VNDP
-
Q
D
LR
A
K
L
E
M
LW
A
S
Y
Y
G
G
V
A
I
T
H
AG
TH
---
LV
H
A
L
SY
P
LG
GK
Y
HL
PHG
V
ANAILL
A
P
C
MAF
V
R
P
---------------
WA
V
E
K
F
ARV
W
DC
I
P
DAETAL
S
AE
E
K
S
H
A
L
V
T
W
LQA
L
VN
QL
K
L
P
N
N
L
AA
L
GV
PP
EDI
AS
L
fig|749546.3.peg.138
Escherichia coli MS 185-1 (6-347/385)
S
T
IL
S
G
A
GAI
PS
L
T
SL
L
P--
D
I
R
KM
L
L
VTD
RN
I
AQL
D
GVQ
Q
I
R
A
L
L
E
KHCP
QVNV
I
D
N
V
P
A
E
PT
HHD
V
RQ
L
MD
A
PGDA
S
F
D
V
VV
G
IGGGS
V
L
D
VA
K
L
L
SVLC
H
P
Q
SPGLDAL
L
A
GEK
P
TQ
--
--
---
-
---
-----------------
RVQ
S
W
L
I
P
TT
A
GTGSE
A
T
PN
A
IL
AI
PEQ
S
T
K
VGII
S
QVLL
P
DY
V
A
L
F
P
ELTTS
MP
AHIA
A
S
T
G
I
DA
L
C
H
L
L
E
C
F
TA
TV
A
NP
-
VS
D
NA
A
LT
G
L
SK
L
FRH
I
Q
P
A
VNDP
-
Q
D
LR
A
K
L
E
M
LW
A
S
Y
Y
G
G
V
A
I
T
H
AG
TH
---
LV
H
A
L
SY
P
LG
GK
Y
HL
PHG
V
ANAILL
A
P
C
MAF
V
R
P
---------------
WA
V
E
K
F
ARV
W
DC
I
P
DAETAL
S
AE
E
K
S
H
A
L
V
T
W
LQA
L
VN
QL
K
L
P
N
N
L
AA
L
GV
PP
EDI
AS
L
fig|749528.3.peg.3962
Escherichia coli MS 45-1 (6-347/385)
S
T
IL
S
G
A
GAI
PS
L
T
SL
L
P--
D
I
R
KM
L
L
VTD
RN
I
AQL
D
GVQ
Q
I
R
A
L
L
E
KHCP
QVNV
I
D
N
V
P
A
E
PT
HHD
V
RQ
L
MD
A
PGDA
S
F
D
V
VV
G
IGGGS
V
L
D
VA
K
L
L
SVLC
H
P
Q
SPGLDAL
L
A
GEK
P
TQ
--
--
---
-
---
-----------------
RVQ
S
W
L
I
P
TT
A
GTGSE
A
T
PN
A
IL
AI
PEQ
S
T
K
VGII
S
QVLL
P
DY
V
A
L
F
P
ELTTS
MP
AHIA
A
S
T
G
I
DA
L
C
H
L
L
E
C
F
TA
TV
A
NP
-
VS
D
NA
A
LT
G
L
SK
L
FRH
I
Q
P
A
VNDP
-
Q
D
LR
A
K
L
E
M
LW
A
S
Y
Y
G
G
V
A
I
T
H
AG
TH
---
LV
H
A
L
SY
P
LG
GK
Y
HL
PHG
V
ANAILL
A
P
C
MAF
V
R
P
---------------
WA
V
E
K
F
ARV
W
DC
I
P
DAETAL
S
AE
E
K
S
H
A
L
V
T
W
LQA
L
VN
QL
K
L
P
N
N
L
AA
L
GV
PP
EDI
AS
L
fig|656440.3.peg.533
Escherichia coli TA206 (6-347/385)
S
T
IL
S
G
A
GAI
PS
L
T
SL
L
P--
D
I
R
KM
L
L
VTD
RN
I
AQL
D
GVQ
Q
I
R
A
L
L
E
KHCP
QVNV
I
D
N
V
P
A
E
PT
HHD
V
RQ
L
MD
A
PGDA
S
F
D
V
VV
G
IGGGS
V
L
D
VA
K
L
L
SVLC
H
P
Q
SPGLDAL
L
A
GEK
P
TQ
--
--
---
-
---
-----------------
RVQ
S
W
L
I
P
TT
A
GTGSE
A
T
PN
A
IL
AI
PEQ
S
T
K
VGII
S
QVLL
P
DY
V
A
L
F
P
ELTTS
MP
AHIA
A
S
T
G
I
DA
L
C
H
L
L
E
C
F
TA
TV
A
NP
-
VS
D
NA
A
LT
G
L
SK
L
FRH
I
Q
P
A
VNDP
-
Q
D
LR
A
K
L
E
M
LW
A
S
Y
Y
G
G
V
A
I
T
H
AG
TH
---
LV
H
A
L
SY
P
LG
GK
Y
HL
PHG
V
ANAILL
A
P
C
MAF
V
R
P
---------------
WA
V
E
K
F
ARV
W
DC
I
P
DAETAL
S
AE
E
K
S
H
A
L
V
T
W
LQA
L
VN
QL
K
L
P
N
N
L
AA
L
GV
PP
EDI
AS
L
fig|685038.3.peg.614
Escherichia coli O83:H1 str. NRG 857C (6-347/385)
S
T
IL
S
G
A
GAI
PS
L
T
SL
L
P--
D
I
R
KM
ML
VTD
RN
I
AQL
D
GVQ
Q
I
R
A
L
L
K
KHCP
QVNI
I
D
N
V
P
A
E
PT
HHD
V
RQ
L
MD
A
LGDA
S
F
D
V
VV
G
IGGGS
V
L
D
VA
K
L
L
SVLC
H
P
Q
SPGLDAL
L
A
GEK
P
TQ
--
--
---
-
---
-----------------
RVQ
S
W
L
I
P
TT
A
GTGSE
A
T
PN
A
IL
AI
PEQ
S
T
K
VGII
S
QVLL
P
DY
V
A
L
F
P
ELTTS
MP
AHIA
A
S
T
G
I
DA
L
C
H
L
L
E
C
F
TA
TV
A
NP
-
VS
D
NA
A
LT
G
L
SK
L
FRH
I
Q
P
A
VNDP
-
Q
D
LR
A
K
L
E
M
LW
A
S
Y
Y
G
G
V
A
I
T
H
AG
TH
---
LV
H
A
L
SY
P
LG
GK
Y
HL
PHG
V
ANAILL
A
P
C
MAF
V
R
P
---------------
WA
V
E
K
F
ARV
W
DC
I
P
DAETAL
S
AE
E
K
S
H
A
L
V
T
W
LQA
L
VN
QL
K
L
P
N
N
L
AA
L
GV
PP
EDI
AS
L
Consen1
Primary consensus
MNNFNLHTPk
IlFgrGai
l
dev
g
r
livtd
l
G
qv
d
l
aaGv
f
gvepnPt
v
g
l
k
d
liaiGGGSp
D
K
i
n
p
--------
e
p
--
qt
e
-----------------
m
av
Tt
gTgsEvt
aVitd
g
K
d
P
A
lDa
mP
A
ggvDA
tHaiE
Yvt
a
-
D
a
al
l
lp
s
-
n
are
v
a
t
Ag
gf
naglg
---
H
maH
Lg
y
pHg
anAillp
v
nad
---------------
r
ky
A
lg
s
e
i
aav
a
l
qlgiP
hlrd
Gv
edIpaLLKN
Consen2
Secondary consensus
t
y
r
s
a
eq
d
itygg
ki
m
-
k
y
eivad
a
l
a
v
g
t
ilg
v
m
e
qefadvrsl
-
-
il
p
-
rfmdirkriykfpkmgv
ci
l
a
aa
sn
y
vsr
r
s
p
l
tv
v
t
is
v
k
h
ii
i
gr
a
s
d
vga
m
g
y
l
al
gvfvpqdw
lg
t
d
a
tl
lvic
l
kr
dnptkqtafsqydrp
g
rl
-
r
a
r
kl
w
f
vkv
ise
l
ss
as
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character