┌─────────────────────────────────────────────────── Escherichia coli (7-338/356) 101-1 (8)  
│                                                                 ┌─ Escherichia coli APEC O1 (9)  
│                                                                ┌┴─ Escherichia coli ED1a (2)  
│                                                               ┌┴─ Escherichia coli 2362-75 (2)  
│                                                              ┌┴┬─ Escherichia coli O83:H1 str. NRG 857C   
│                                                              │ └┬─ Escherichia coli H299   
│                                                             ┌┤  └─ Escherichia coli F11 (3)  
│                                                            ┌┤└─ Escherichia coli 83972 (5)  
│                                                           ┌┤└─ Escherichia coli NC101   
│                                                          ┌┤└─ Escherichia coli 536 (1)  
│                                                         ┌┤└─ Escherichia coli TA280   
│                                                        ┌┤└─ Escherichia coli B354   
│                                                       ┌┤└─ Escherichia coli MS 115-1   
│                                                      ┌┤└─ Escherichia coli 1044A (23)  
│                                                     ┌┤└─ Escherichia coli O157:H7 EDL933  [2] 
│                                                    ┌┤└─ Escherichia coli M718   
│                                                    │└┬─ Escherichia coli MS 69-1   
│                                                    │ └┬─ Escherichia coli 042 (6)  
│                                                   ┌┤  └─ Escherichia coli B185   
│                                                   ││ ┌─ fig|1040638.4.peg.2229 O104:H4 str. LB226692 (20)  
│                                                   │└┬┴─ Escherichia coli MS 124-1 (1)  
│                                                  ┌┤ └┬─ Escherichia coli B171 (1)  
┤                                                  ││  └─ Escherichia coli TA271   
│                                                 ┌┤└─ Escherichia coli 53638 (1)  
│                                                ┌┤└─ Escherichia coli K12 (22)  
│         ┌──────────────────────────────────────┤└─ Escherichia coli (13-339/339) 1827-70 (6)  
│     ┌───┤                                      └─ Escherichia coli O111:H- str. 11128   
│     │   └─────────────────────────────────┬── Escherichia coli (7-332/334) MS 115-1   
│     │                                     └───┬─ Escherichia coli (8-333/335) MS 124-1 (1)  
│     │                                         └┬─ Escherichia coli (8-333/335) IAI39 (1)  
│     │                                          └─ Escherichia coli (8-333/335) 2362-75 (12)  
│     │                                                   ┌─ Escherichia coli (4-332/332) M605   
│     │                                                  ┌┴─ Escherichia coli (4-332/332) SE15   
│     │                                                 ┌┴┬─ Escherichia coli (4-332/332) NC101   
│     │                                                ┌┤ └─ Escherichia coli (4-332/332) 2362-75 (14)  
│     │                                               ┌┤└─ Escherichia coli (4-332/332) APEC O1 (6)  
│     │                                              ┌┤└─ Escherichia coli (4-332/332) WV_060327   
│     │                                              │└┬─ Escherichia coli (4-332/332) SMS-3-5   
│     │                                             ┌┤ └─ Escherichia coli (4-332/332) MS 21-1   
│     │                                            ┌┤└─ Escherichia coli (4-332/332) ED1a (2)  
│     │                                           ┌┤└─ Escherichia coli (4-332/332) H299   
│     │                                          ┌┤└─ Escherichia coli (4-332/332) IAI39 (1)  
│     │                                         ┌┤└─ Escherichia coli (4-332/332) M718   
│     │                                        ┌┤└─ Escherichia coli (4-332/332) MS 69-1   
│     │                                       ┌┤└─ fig|1040638.4.peg.4084 O104:H4 (4-332/332) str. LB226692 (5)  
└─────┤                                       │└┬─ Escherichia coli (4-332/332) E110019 (1)  
      │                                      ┌┤ └┬─ Escherichia coli (4-332/332) O111:H- str. 11128   
      │                                      ││  └─ Escherichia coli (4-332/332) B088 (23)  
      │                                  ┌───┤└┬─ Escherichia coli (4-332/332) MS 196-1   
      │                                  │   │ └─ Escherichia coli (4-332/332) K12 (25)  
      │   ┌──────────────────────────────┤   └┬─ Escherichia coli (4-332/332) O55:H7 str. CB9615   
      │   │                              │    └─ Escherichia coli (4-332/332) 1044A (24)  
      │   │                              └────── Escherichia coli (4-327/336) O157:H7 str. EC4024   
      │   │                                   ┌─ Escherichia coli (10-338/341) MS 69-1   
      │   │                                  ┌┴─ Escherichia coli (1-327/330) SE15   
      │   │                                 ┌┴─ Escherichia coli (10-338/341) M605   
      │   │                                ┌┴─ Escherichia coli (10-338/341) ED1a (1)  
      │   │                               ┌┴─ Escherichia coli (10-338/341) K12 (64)  
      │   │                              ┌┴┬─ Escherichia coli (1-327/330) 101-1 (48)  
      │   │                             ┌┤ └─ Escherichia coli (1-327/330) H736 (1)  
      │   │                            ┌┤└─ Escherichia coli (10-338/341) 2362-75 (2)  
      │   │                            │└┬─ fig|1040638.4.peg.1350 O104:H4 (1-327/330) str. LB226692 (3)  
      │   │         ┌──────────────────┤ └─ Escherichia coli (10-338/341) 55989 (2)  
      │   │    ┌────┤                  └─ Escherichia coli (10-338/341) MS 115-1   
      └───┤    │    └───────────────────────┬─ Escherichia coli (1-325/341) E24377A (1)  
          │    │                            └┬─ Escherichia coli (1-308/324) B088   
          │    │                             └┬─ Escherichia coli (1-325/341) K12 (75)  
          │    │                              └┬─ Escherichia coli (1-325/341) ABU 83972 (3)  
          │    │                               └─ Escherichia coli (1-325/341) 2362-75 (13)  
          │    │                                           ┌─ Escherichia coli (1-325/343) TA206   
          │    │                                          ┌┴─ Escherichia coli (1-325/343) NC101   
          │    │                                         ┌┴─ Escherichia coli (1-325/343) 2362-75 (27)  
          │    │                                        ┌┴┬─ Escherichia coli (1-325/343) MS 21-1   
          │    │                                       ┌┤ └─ Escherichia coli (1-325/343) B185 (4)  
          │    │                                      ┌┤└─ Escherichia coli (1-325/343) K12 (20)  
          │    │                                     ┌┤└─ Escherichia coli (1-325/343) 1044A (24)  
          │    │                                    ┌┤└─ Escherichia coli (1-325/343) 53638 (1)  
          │    │                                    │└┬─ fig|1040638.4.peg.2734 O104:H4 (1-325/343) str. LB226692 (36)  
          │    │                       ┌────────────┤ └┬─ Escherichia coli (1-325/343) MS 124-1 (1)  
          └────┤                       │            │  └─ Escherichia coli (1-325/343) IAI1 (4)  
               │                       │            └─ Escherichia coli (1-325/343) MS 115-1   
               │     ┌─────────────────┤          ┌─ Escherichia coli (1-324/346) B str. REL606 (3)  
               │     │                 │         ┌┴─ Escherichia coli (1-308/346) 101-1   
               │     │                 └─────────┤  ┌─ Escherichia coli (1-324/346) B185   
               │     │                           │ ┌┴─ Escherichia coli (1-324/346) 1044A (25)  
               │     │                           └┬┴─ Escherichia coli (1-324/346) B171 (4)  
               │  ┌──┤                            └┬─ Escherichia coli (1-324/346) K12 (12)  
               │  │  │                             └┬─ Escherichia coli (1-324/346) B7A (6)  
               │  │  │                              └┬─ fig|1040638.4.peg.3225 O104:H4 (1-324/346) str. LB226692 (3)  
               │  │  │                               └─ Escherichia coli (3-326/348) 042 (36)  
               │  │  └──────────────────────────── Escherichia coli (12-339/344) 83972 (13)  
               │  │                                            ┌─ Escherichia coli (8-319/331) 1044A (41)  
               │  │                                           ┌┴─ Escherichia coli (1-309/321) O157:H7 EDL933 (1)  
               │  │                                          ┌┴─ fig|1040638.4.peg.2021 O104:H4 (8-319/331) str. LB226692 (13)  
               │  │                                         ┌┴┬─ Escherichia coli (8-319/331) MS 185-1   
               └──┤                                        ┌┤ └─ Escherichia coli (8-319/331) MS 21-1   
                  │                                        │└┬─ Escherichia coli (8-319/331) 101-1 (7)  
                  │                                       ┌┤ └─ Escherichia coli (8-319/331) 042 (53)  
                  │  ┌────────────────────────────────────┤└─ Escherichia coli (8-319/331) APEC O1 (6)  
                  │  │                                    └─ Escherichia coli (8-319/331) M718   
                  │  │                                              ┌─ Escherichia coli (6-314/315) ED1a (1)  
                  │  │                                             ┌┴─ Escherichia coli (6-314/315) MS 145-7   
                  │  │                                            ┌┴─ Escherichia coli (6-314/315) 536 (12)  
                  │  │                                           ┌┴─ Escherichia coli (6-314/315) K12 (8)  
                  │  │                                          ┌┴┬─ Escherichia coli (6-314/315) TA280   
                  └──┤                                         ┌┤ └─ fig|1040638.4.peg.942 O104:H4 (6-314/315) str. LB226692 (54)  
                     │                                         │└┬─ Escherichia coli (6-314/315) 101-1 (2)  
                     │                                        ┌┤ └┬─ Escherichia coli (6-314/315) TA143   
                     │                                        ││  └─ Escherichia coli (6-314/315) 042 (1)  
                     │                                        │└┬─ Escherichia coli (6-314/315) 1125A (21)  
                     │  ┌─────────────────────────────────────┤ └┬─ Escherichia coli (6-314/315) O157:H7 EDL933 (1)  
                     │  │                                     │  └─ Escherichia coli (6-314/315) 1044A (4)  
                     │  │                                     └─ Escherichia coli (6-314/315) B088 (16)  
                     └──┤                                    ┌─ Escherichia coli (6-330/356) MS 116-1   
                        │                      ┌─────────────┴─ Escherichia coli (6-330/356) H736   
                        │                   ┌──┴───────────────────── Escherichia coli (6-330/358) TA206   
                        └───────────────────┤               ┌─ Escherichia coli (5-329/360) SMS-3-5   
                                            └───────────────┤┌─ Escherichia coli (5-329/360) MS 21-1   
                                                            └┤┌─ Escherichia coli (5-329/360) FVEC1302 (3)  
                                                             ││  ┌─ Escherichia coli (8-332/363) K12 (31)  
                                                             └┤ ┌┴─ Escherichia coli (5-329/360) E24377A (1)  
                                                              │┌┴─ Escherichia coli (8-332/363) HS (1)  
                                                              └┤ ┌─ Escherichia coli (8-332/363) 042 (1)  
                                                               │┌┴─ Escherichia coli (5-329/360) TA143   
                                                               └┤┌─ Escherichia coli (5-329/360) 2362-75 (25)  
                                                                ││  ┌─ Escherichia coli (5-329/360) B088 (6)  
                                                                └┤ ┌┴─ fig|1040638.4.peg.5358 O104:H4 (5-329/360) str. LB226692 (5)  
                                                                 │┌┴─ Escherichia coli (5-329/360) MS 115-1   
                                                                 └┤┌─ Escherichia coli (5-329/360) O83:H1 str. NRG 857C   
                                                                  └┤ ┌─ Escherichia coli (5-329/360) TA206   
                                                                   └┬┴─ Escherichia coli (5-329/360) 83972 (7)  
                                                                    └┬─ Escherichia coli (5-329/360) 536 (9)  
                                                                     └┬─ Escherichia coli (5-329/360) M605   
                                                                      └─ Escherichia coli (5-329/360) H299   
  
Evolved beta-D-galactosidase transcriptional repressor (25)
Transcriptional repressor of the lac operon (20)
Transcriptional regulator YcjW, LacI family, possibly involved in maltodextrin utilization pathway (20)
Trehalose operon transcriptional repressor (12)
Galactose operon repressor, GalR-LacI family of transcriptional regulators (11)
Transcriptional (co)regulator CytR (10)
Gluconate utilization system Gnt-I transcriptional repressor (8)
Mgl repressor and galactose ultrainduction factor GalS, HTH-type transcriptional regulator (8)
Purine nucleotide synthesis repressor (5)
Sucrose operon repressor ScrR, LacI family (4)
Transcriptional regulator, LacI family (2)
hypothetical transcriptional regulator YcjW (1)
Others (8)