fig|216592.1.peg.799
Escherichia coli 042 (34-428/428)
MK
P
L
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D
H
KKLDDVLNNRAPDGKTHELSS
fig|344610.3.peg.70
Escherichia coli 53638 (34-428/428)
MK
P
L
GDGFV
K
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I
A
P
V
I
F
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GV
A
TI
V
V
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K
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L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|405955.9.peg.3323
Escherichia coli APEC O1 (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
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M
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GV
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V
V
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K
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L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|481805.3.peg.196
Escherichia coli ATCC 8739 (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
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V
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TI
V
V
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V
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L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|344601.3.peg.2987
Escherichia coli B171 (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
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M
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I
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V
V
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D
H
KKLDDVLNNRAPDGKTHELSS
fig|340184.3.peg.326
Escherichia coli B7A (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
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V
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V
V
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V
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L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|199310.1.peg.4245
Escherichia coli CFT073 (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
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V
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V
V
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V
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L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|340186.3.peg.1660
Escherichia coli E110019 (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
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N
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GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|340185.3.peg.72
Escherichia coli E22 (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
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A
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V
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M
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L
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L
L
L
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A
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SG
F
I
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A
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H
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A
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L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|331111.12.peg.4258
Escherichia coli E24377A (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
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T
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L
YFE
IV
S
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L
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L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
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A
V
Y
-----
A
D
Q
A
K
D
Q
GI
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I
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A
S
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G
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A
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---
IL
Q
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---
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Q
L
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M
I
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A
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T
IG
KY
G
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L
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LG
Q
L
I
I
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Y
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I
LF
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S
I
A
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G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
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A
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M
L
D
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LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
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S
-
I
Y
L
T
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NS
Q
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M
DI
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IV
L
L
L
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SG
F
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H
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A
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L
G
I
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F
M
SE
AR
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N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|331111.3.peg.1668
Escherichia coli E24377A (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|562.375.peg.506
Escherichia coli EC4100B (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|340197.3.peg.636
Escherichia coli F11 (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|656379.3.peg.4851
Escherichia coli FVEC1302 (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|656380.3.peg.4637
Escherichia coli FVEC1412 (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|656414.3.peg.4033
Escherichia coli H736 (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|331112.3.peg.3498
Escherichia coli HS (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|83333.1.peg.3461
Escherichia coli K12 (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|656419.3.peg.4547
Escherichia coli M718 (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|585056.7.peg.4204
Escherichia coli UMN026 (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|316407.3.peg.3601
Escherichia coli W3110 (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
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I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
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F
T
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KY
G
VGT
L
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LG
Q
L
I
I
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I
LF
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S
I
A
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G
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S
IF
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IR
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I
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EL
LI
V
LG
T
S
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A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
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S
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H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|749527.3.peg.1609
Escherichia coli MS 21-1 (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
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S
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S
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I
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G
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IN
M
I
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I
G
A
F
GA
MA
F
T
IG
KY
G
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L
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LG
Q
L
I
I
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Y
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I
LF
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S
I
A
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IF
K
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IR
Y
I
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EL
LI
V
LG
T
S
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A
LPR
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L
D
-
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K
LG
C
R
K
S
V
V
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V
I
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T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
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L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
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S
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H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GI
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|216593.1.peg.4260
Escherichia coli E2348/69 (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
T
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
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HR
L
---
-
G
S
KG
Q
L
I
F
N
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E
S
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S
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I
F
G
I
IN
M
I
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I
G
A
F
GA
MA
F
T
IG
KY
G
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L
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LG
Q
L
I
I
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Y
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I
LF
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S
I
A
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G
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IF
K
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IR
Y
I
RE
EL
LI
V
LG
T
S
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A
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M
L
D
-
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K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
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S
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H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|83334.1.peg.4380
Escherichia coli O157:H7 (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
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S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
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L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
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L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDD
A
LNNRAPDGKTHELSS
fig|155864.1.peg.4416
Escherichia coli O157:H7 EDL933 (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
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I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
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I
LF
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S
I
A
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G
F
S
IF
K
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IR
Y
I
RE
EL
LI
V
LG
T
S
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A
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L
D
-
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K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
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AT
NS
Q
-
M
DI
VHQ
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L
IV
L
L
L
SSKG
A
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T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDD
A
LNNRAPDGKTHELSS
fig|155864.8.peg.4364
Escherichia coli O157:H7 EDL933 (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
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LG
Q
L
I
I
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Y
ITC
I
LF
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S
I
A
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G
F
S
IF
K
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IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
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K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
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AT
NS
Q
-
M
DI
VHQ
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L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
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S
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H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDD
A
LNNRAPDGKTHELSS
fig|444449.5.peg.2948
Escherichia coli O157:H7 str. EC4042 (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
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I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
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I
LF
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S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
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KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
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L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDD
A
LNNRAPDGKTHELSS
fig|444447.5.peg.1865
Escherichia coli O157:H7 str. EC4206 (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
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I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
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L
VQ
LG
Q
L
I
I
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Y
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I
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S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
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A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
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L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDD
A
LNNRAPDGKTHELSS
fig|544404.4.peg.4594
Escherichia coli O157:H7 str. TW14359 (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDD
A
LNNRAPDGKTHELSS
fig|502346.5.peg.2236
Escherichia coli O157:H7 str. TW14588 (34-428/428)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDD
A
LNNRAPDGKTHELSS
fig|413997.3.peg.3542
Escherichia coli B str. REL606
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
F
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|511693.5.peg.3560
Escherichia coli BL21
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
F
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|469008.4.peg.222
Escherichia coli BL21(DE3)
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
F
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|1040638.4.peg.2162
Escherichia coli O104:H4 str. LB226692
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|6666666.5357.peg.349
Escherichia coli TY-2482
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|216592.3.peg.3973
Escherichia coli 042
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|358709.5.peg.280
Escherichia coli 101-1
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|670888.3.peg.2712
Escherichia coli 1827-70
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|362663.8.peg.3661
Escherichia coli 536
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|362663.9.peg.3674
Escherichia coli 536
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|344610.7.peg.2692
Escherichia coli 53638
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|585055.6.peg.4004
Escherichia coli 55989
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|585055.8.peg.4006
Escherichia coli 55989
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|525281.3.peg.2980
Escherichia coli 83972
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|655817.3.peg.4143
Escherichia coli ABU 83972
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|405955.13.peg.3972
Escherichia coli APEC O1
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|481805.6.peg.202
Escherichia coli ATCC 8739
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|550672.3.peg.3580
Escherichia coli B088
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|344601.5.peg.3112
Escherichia coli B171
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|550676.3.peg.3709
Escherichia coli B185
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|550677.3.peg.4093
Escherichia coli B354
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|340184.6.peg.339
Escherichia coli B7A
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|199310.4.peg.4077
Escherichia coli CFT073
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|536056.3.peg.190
Escherichia coli DH1
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|340186.5.peg.1713
Escherichia coli E110019
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|340185.4.peg.79
Escherichia coli E22
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|585397.7.peg.4197
Escherichia coli ED1a
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|316401.4.peg.4283
Escherichia coli ETEC H10407
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|340197.5.peg.660
Escherichia coli F11
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|656393.3.peg.4607
Escherichia coli H299
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|656408.3.peg.3964
Escherichia coli H591
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|331112.6.peg.3641
Escherichia coli HS
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|585034.4.peg.3600
Escherichia coli IAI1
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|585034.5.peg.3598
Escherichia coli IAI1
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|585057.4.peg.4164
Escherichia coli IAI39
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|585057.6.peg.4172
Escherichia coli IAI39
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|714962.3.peg.4004
Escherichia coli IHE3034
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|595495.4.peg.3906
Escherichia coli KO11
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|656417.3.peg.4401
Escherichia coli M605
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|679207.4.peg.270
Escherichia coli MS 107-1
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|749538.3.peg.3975
Escherichia coli MS 116-1
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|679206.4.peg.1851
Escherichia coli MS 119-7
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|679205.4.peg.5078
Escherichia coli MS 124-1
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|679204.3.peg.3293
Escherichia coli MS 145-7
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|749540.3.peg.2536
Escherichia coli MS 146-1
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|749544.3.peg.886
Escherichia coli MS 175-1
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|749545.3.peg.586
Escherichia coli MS 182-1
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|749546.3.peg.660
Escherichia coli MS 185-1
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|749547.3.peg.345
Escherichia coli MS 187-1
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|749548.3.peg.3899
Escherichia coli MS 196-1
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|749549.3.peg.1454
Escherichia coli MS 198-1
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|749550.3.peg.816
Escherichia coli MS 200-1
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|749528.3.peg.26
Escherichia coli MS 45-1
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|749531.3.peg.4387
Escherichia coli MS 69-1
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|749532.3.peg.1543
Escherichia coli MS 78-1
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|749533.3.peg.5220
Escherichia coli MS 84-1
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|753642.3.peg.4406
Escherichia coli NC101
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|585395.4.peg.4450
Escherichia coli O103:H2 str. 12009
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|585396.4.peg.4492
Escherichia coli O111:H- str. 11128
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|573235.3.peg.4735
Escherichia coli O26:H11 str. 11368
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|701177.3.peg.4284
Escherichia coli O55:H7 str. CB9615
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|685038.3.peg.3579
Escherichia coli O83:H1 str. NRG 857C
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|585035.6.peg.3866
Escherichia coli S88
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|409438.11.peg.3971
Escherichia coli SE11
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|431946.3.peg.3499
Escherichia coli SE15
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|439855.10.peg.3980
Escherichia coli SMS-3-5
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|656437.3.peg.3974
Escherichia coli TA143
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|656440.3.peg.3796
Escherichia coli TA206
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|656443.3.peg.4443
Escherichia coli TA271
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|869729.3.peg.3813
Escherichia coli UM146
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|364106.7.peg.3972
Escherichia coli UTI89
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|364106.8.peg.3973
Escherichia coli UTI89
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|566546.3.peg.4223
Escherichia coli W
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|566546.4.peg.3749
Escherichia coli W
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|562.376.peg.2713
Escherichia coli WV_060327
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|511145.12.peg.3638
Escherichia coli str. K-12 substr. MG1655
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|511145.6.peg.3620
Escherichia coli str. K-12 substr. MG1655
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|670897.3.peg.3823
Escherichia coli 2362-75
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
T
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|574521.7.peg.3859
Escherichia coli O127:H6 str. E2348/69
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
T
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|562.371.peg.3281
Escherichia coli 1044A
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDD
A
LNNRAPDGKTHELSS
fig|562.373.peg.1694
Escherichia coli 1125A
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDD
A
LNNRAPDGKTHELSS
fig|562.372.peg.4161
Escherichia coli 1212A
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDD
A
LNNRAPDGKTHELSS
fig|562.374.peg.5153
Escherichia coli 536A
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDD
A
LNNRAPDGKTHELSS
fig|444454.5.peg.3494
Escherichia coli O157:H7 str. EC4024
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDD
A
LNNRAPDGKTHELSS
fig|444448.5.peg.1702
Escherichia coli O157:H7 str. EC4045
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDD
A
LNNRAPDGKTHELSS
fig|444453.5.peg.1233
Escherichia coli O157:H7 str. EC4076
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDD
A
LNNRAPDGKTHELSS
fig|444452.5.peg.109
Escherichia coli O157:H7 str. EC4113
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDD
A
LNNRAPDGKTHELSS
fig|444450.8.peg.4783
Escherichia coli O157:H7 str. EC4115
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDD
A
LNNRAPDGKTHELSS
fig|444451.5.peg.283
Escherichia coli O157:H7 str. EC4196
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDD
A
LNNRAPDGKTHELSS
fig|478004.5.peg.259
Escherichia coli O157:H7 str. EC4401
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDD
A
LNNRAPDGKTHELSS
fig|478005.5.peg.217
Escherichia coli O157:H7 str. EC4486
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDD
A
LNNRAPDGKTHELSS
fig|478006.5.peg.224
Escherichia coli O157:H7 str. EC4501
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDD
A
LNNRAPDGKTHELSS
fig|478007.5.peg.232
Escherichia coli O157:H7 str. EC508
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDD
A
LNNRAPDGKTHELSS
fig|478008.5.peg.753
Escherichia coli O157:H7 str. EC869
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDD
A
LNNRAPDGKTHELSS
fig|637388.3.peg.1945
Escherichia coli O157:H7 str. FRIK2000
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDD
A
LNNRAPDGKTHELSS
fig|570506.3.peg.76
Escherichia coli O157:H7 str. FRIK966
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDD
A
LNNRAPDGKTHELSS
fig|386585.9.peg.4607
Escherichia coli O157:H7 str. Sakai
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDD
A
LNNRAPDGKTHELSS
fig|595496.3.peg.3519
Escherichia coli BW2952
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
I
AAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|316385.5.peg.3654
Escherichia coli str. K-12 substr. DH10B
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
I
AAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|316385.7.peg.3739
Escherichia coli str. K-12 substr. DH10B
MK
P
L
GDGFV
K
LIKMI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
I
AAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|585397.9.peg.4194
Escherichia coli ED1a
MI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRAPDGKTHELSS
fig|656444.3.peg.4832
Escherichia coli TA280
MI
I
A
P
V
I
F
C
T
V
V
T
GIAG
M
E
S
M
K
AV
GR
T
GA
V
AL
L
YFE
IV
S
TIA
L
IIG
L
I
I
V
NV
V
--------
QPGAG
MN
VD
P
A
T
L
D
A
KAV
A
V
Y
-----
A
D
Q
A
K
D
Q
GI
VAF
I
MD
V
IP
A
S
VI
G
AF
A
S
GN
---
IL
Q
V
L
L
FAVLFG
F
AL
HR
L
---
-
G
S
KG
Q
L
I
F
N
VI
E
S
F
S
QV
I
F
G
I
IN
M
I
MRLAP
I
G
A
F
GA
MA
F
T
IG
KY
G
VGT
L
VQ
LG
Q
L
I
I
CF
Y
ITC
I
LF
VVL
VLG
S
I
A
KAT
G
F
S
IF
K
F
IR
Y
I
RE
EL
LI
V
LG
T
S
SSES
A
LPR
M
L
D
-
KME
K
LG
C
R
K
S
V
V
GL
V
I
PTGYSFNLDG
T
S
-
I
Y
L
T
MAAVFIAQ
AT
NS
Q
-
M
DI
VHQ
ITL
L
IV
L
L
L
SSKG
A
AGV
T
G
SG
F
I
VL
A
ATL
S
AVG
H
LPV
A
GLALI
L
G
I
DR
F
M
SE
AR
ALT
N
L
VGN
GV
A
TI
V
V
AKW
V
K
E
L
D
H
KKLDDVLNNRA
L
DGKTHELSS
fig|550676.3.peg.4349
Escherichia coli B185 (41-422/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
AL
D
fig|585397.7.peg.4790
Escherichia coli ED1a (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
S
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|585397.9.peg.4790
Escherichia coli ED1a (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
S
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|340186.3.peg.1007
Escherichia coli E110019 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
S
L
V
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|340186.5.peg.1049
Escherichia coli E110019 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
S
L
V
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|344601.3.peg.1103
Escherichia coli B171 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TTIA
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|344601.5.peg.1168
Escherichia coli B171 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TTIA
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|340185.3.peg.1365
Escherichia coli E22 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TTIA
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|340185.4.peg.1448
Escherichia coli E22 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TTIA
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|585395.4.peg.5069
Escherichia coli O103:H2 str. 12009 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TTIA
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|405955.13.peg.4571
Escherichia coli APEC O1 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|405955.9.peg.3859
Escherichia coli APEC O1 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|714962.3.peg.4609
Escherichia coli IHE3034 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|585035.6.peg.4470
Escherichia coli S88 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|869729.3.peg.4421
Escherichia coli UM146 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|364106.7.peg.4545
Escherichia coli UTI89 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|364106.8.peg.4544
Escherichia coli UTI89 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|550677.3.peg.78
Escherichia coli B354 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|656417.3.peg.5154
Escherichia coli M605 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|431946.3.peg.4111
Escherichia coli SE15 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|216592.1.peg.2376
Escherichia coli 042 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|216592.3.peg.4619
Escherichia coli 042 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|562.371.peg.3589
Escherichia coli 1044A (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|562.373.peg.5815
Escherichia coli 1125A (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|562.372.peg.3469
Escherichia coli 1212A (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|670897.3.peg.1386
Escherichia coli 2362-75 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|362663.8.peg.4344
Escherichia coli 536 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|362663.9.peg.4360
Escherichia coli 536 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|562.374.peg.2804
Escherichia coli 536A (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|525281.3.peg.1800
Escherichia coli 83972 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|655817.3.peg.4816
Escherichia coli ABU 83972 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|481805.3.peg.4245
Escherichia coli ATCC 8739 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|481805.6.peg.4230
Escherichia coli ATCC 8739 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|340184.3.peg.3871
Escherichia coli B7A (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|340184.6.peg.4045
Escherichia coli B7A (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|199310.1.peg.4969
Escherichia coli CFT073 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|199310.4.peg.4759
Escherichia coli CFT073 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|216593.1.peg.3937
Escherichia coli E2348/69 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|340197.3.peg.2095
Escherichia coli F11 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|340197.5.peg.2207
Escherichia coli F11 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|656379.3.peg.455
Escherichia coli FVEC1302 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|656380.3.peg.447
Escherichia coli FVEC1412 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|656393.3.peg.187
Escherichia coli H299 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|656414.3.peg.4630
Escherichia coli H736 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|585057.4.peg.4639
Escherichia coli IAI39 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|585057.6.peg.4648
Escherichia coli IAI39 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|656419.3.peg.5315
Escherichia coli M718 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|749538.3.peg.284
Escherichia coli MS 116-1 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|679204.3.peg.3016
Escherichia coli MS 145-7 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|749540.3.peg.1639
Escherichia coli MS 146-1 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|749544.3.peg.3132
Escherichia coli MS 175-1 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|749546.3.peg.5027
Escherichia coli MS 185-1 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|749548.3.peg.393
Escherichia coli MS 196-1 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|749549.3.peg.1611
Escherichia coli MS 198-1 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|749550.3.peg.1416
Escherichia coli MS 200-1 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|749527.3.peg.2938
Escherichia coli MS 21-1 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|749528.3.peg.640
Escherichia coli MS 45-1 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|749531.3.peg.2343
Escherichia coli MS 69-1 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|753642.3.peg.4067
Escherichia coli NC101 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|574521.7.peg.4501
Escherichia coli O127:H6 str. E2348/69 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|83334.1.peg.5036
Escherichia coli O157:H7 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|155864.1.peg.5018
Escherichia coli O157:H7 EDL933 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|155864.8.peg.4998
Escherichia coli O157:H7 EDL933 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|444454.5.peg.4138
Escherichia coli O157:H7 str. EC4024 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|444449.5.peg.3592
Escherichia coli O157:H7 str. EC4042 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|444448.5.peg.2349
Escherichia coli O157:H7 str. EC4045 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|444453.5.peg.1986
Escherichia coli O157:H7 str. EC4076 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|444452.5.peg.1177
Escherichia coli O157:H7 str. EC4113 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|444450.8.peg.5428
Escherichia coli O157:H7 str. EC4115 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|444451.5.peg.2090
Escherichia coli O157:H7 str. EC4196 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|444447.5.peg.2515
Escherichia coli O157:H7 str. EC4206 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|478004.5.peg.2039
Escherichia coli O157:H7 str. EC4401 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|478005.5.peg.569
Escherichia coli O157:H7 str. EC4486 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|478006.5.peg.1451
Escherichia coli O157:H7 str. EC4501 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|478007.5.peg.1086
Escherichia coli O157:H7 str. EC508 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|478008.5.peg.100
Escherichia coli O157:H7 str. EC869 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|637388.3.peg.2314
Escherichia coli O157:H7 str. FRIK2000 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|570506.3.peg.1409
Escherichia coli O157:H7 str. FRIK966 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|386585.9.peg.5286
Escherichia coli O157:H7 str. Sakai (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|544404.4.peg.5240
Escherichia coli O157:H7 str. TW14359 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|502346.5.peg.1583
Escherichia coli O157:H7 str. TW14588 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|701177.3.peg.4906
Escherichia coli O55:H7 str. CB9615 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|685038.3.peg.4170
Escherichia coli O83:H1 str. NRG 857C (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|439855.10.peg.4655
Escherichia coli SMS-3-5 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|656437.3.peg.4593
Escherichia coli TA143 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|656440.3.peg.4654
Escherichia coli TA206 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|656444.3.peg.5539
Escherichia coli TA280 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|585056.7.peg.4778
Escherichia coli UMN026 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|562.376.peg.1739
Escherichia coli WV_060327 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|1040638.4.peg.1124
Escherichia coli O104:H4 str. LB226692 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|6666666.5357.peg.2289
Escherichia coli TY-2482 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|358709.5.peg.1824
Escherichia coli 101-1 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|670888.3.peg.4665
Escherichia coli 1827-70 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|344610.3.peg.1347
Escherichia coli 53638 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|344610.7.peg.2057
Escherichia coli 53638 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|585055.6.peg.4598
Escherichia coli 55989 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|585055.8.peg.4603
Escherichia coli 55989 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|511693.5.peg.4185
Escherichia coli BL21 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|469008.4.peg.4105
Escherichia coli BL21(DE3) (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|331111.12.peg.4843
Escherichia coli E24377A (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|331111.3.peg.2232
Escherichia coli E24377A (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|562.375.peg.3002
Escherichia coli EC4100B (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|656408.3.peg.4577
Escherichia coli H591 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|331112.3.peg.4034
Escherichia coli HS (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|331112.6.peg.4211
Escherichia coli HS (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|585034.4.peg.4190
Escherichia coli IAI1 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|585034.5.peg.4185
Escherichia coli IAI1 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|679207.4.peg.2967
Escherichia coli MS 107-1 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|749537.3.peg.770
Escherichia coli MS 115-1 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|679206.4.peg.4413
Escherichia coli MS 119-7 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|679205.4.peg.1285
Escherichia coli MS 124-1 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|749545.3.peg.2382
Escherichia coli MS 182-1 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|749547.3.peg.2688
Escherichia coli MS 187-1 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|749532.3.peg.4615
Escherichia coli MS 78-1 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|749533.3.peg.4314
Escherichia coli MS 84-1 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|573235.3.peg.5364
Escherichia coli O26:H11 str. 11368 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|409438.11.peg.4555
Escherichia coli SE11 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|656443.3.peg.5066
Escherichia coli TA271 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|566546.3.peg.2229
Escherichia coli W (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|566546.4.peg.4377
Escherichia coli W (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|595496.3.peg.4148
Escherichia coli BW2952 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
V
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|536056.3.peg.4158
Escherichia coli DH1 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
V
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|83333.1.peg.3987
Escherichia coli K12 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
V
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|595495.4.peg.3118
Escherichia coli KO11 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
V
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|316407.3.peg.3914
Escherichia coli W3110 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
V
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|316385.7.peg.4307
Escherichia coli str. K-12 substr. DH10B (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
V
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|511145.12.peg.4201
Escherichia coli str. K-12 substr. MG1655 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
V
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|511145.6.peg.4183
Escherichia coli str. K-12 substr. MG1655 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
V
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|413997.3.peg.4164
Escherichia coli B str. REL606 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
V
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|316401.4.peg.4981
Escherichia coli ETEC H10407 (41-419/437)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|585396.4.peg.5157
Escherichia coli O111:H- str. 11128 (41-419/429)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|550672.3.peg.4162
Escherichia coli B088 (2-380/398)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
A
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|316385.5.peg.4219
Escherichia coli str. K-12 substr. DH10B (2-380/398)
LSP
A
GD
I
F
I
H
LIKMIV
V
PIV
I
S
TLV
V
GIAGV
G
DAKQLGRIGA
K
TI
I
YFE
VI
TT
V
A
I
I
L
GI
T
L
A
NVF
--------
QPGAG
--
VD
M
S
Q
L
A
T
VDI
S
K
Y
QSTTE
A
V
Q
S
S
S
H
GI
MGT
ILS
L
V
P
T
N
IV
A
SM
A
K
G
E
---
M
L
P
I
I
F
F
S
VLFG
L
G
L
SS
L
---
P
A
T
HR
E
P
L
V
TV
F
R
S
I
S
ET
MFKV
TH
MVMR
Y
AP
V
GVFAL
I
A
V
TVA
NF
G
FSS
L
WP
L
A
K
LVL
LV
H
FAI
L
F
F
ALV
VLG
I
VA
RLC
G
L
S
VW
I
L
IR
I
L
KD
EL
IL
A
YS
T
A
SSES
V
LPR
I
IE
-
KME
A
Y
G
A
P
V
SI
T
SFV
V
PTGYSFNLDG
S
T
-
LY
Q
S
I
AA
I
FIAQ
LY
GI
D
-
L
S
I
WQE
I
I
LV
LT
L
M
V
T
SKG
I
AGV
P
G
VS
F
V
VLLATL
G
S
VG
-
I
P
L
E
GLA
F
I
A
GVDR
I
LDMARTALNVVGN
AL
A
VL
V
I
AKW
E
H
K
F
D
R
KK
fig|216592.1.peg.1268
Escherichia coli 042 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|216592.3.peg.1969
Escherichia coli 042 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|656379.3.peg.2201
Escherichia coli FVEC1302 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|656380.3.peg.3165
Escherichia coli FVEC1412 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|656393.3.peg.2526
Escherichia coli H299 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|585057.4.peg.1387
Escherichia coli IAI39 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|585057.6.peg.1387
Escherichia coli IAI39 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|749549.3.peg.2493
Escherichia coli MS 198-1 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|749527.3.peg.3474
Escherichia coli MS 21-1 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|749531.3.peg.349
Escherichia coli MS 69-1 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|439855.10.peg.1621
Escherichia coli SMS-3-5 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|656437.3.peg.1956
Escherichia coli TA143 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|656444.3.peg.2638
Escherichia coli TA280 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|585056.7.peg.2204
Escherichia coli UMN026 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|585035.6.peg.1771
Escherichia coli S88 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
L
LAL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|405955.13.peg.1819
Escherichia coli APEC O1 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
L
LAL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|405955.9.peg.1484
Escherichia coli APEC O1 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
L
LAL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|714962.3.peg.1884
Escherichia coli IHE3034 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
L
LAL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|869729.3.peg.1804
Escherichia coli UM146 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
L
LAL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|364106.7.peg.1963
Escherichia coli UTI89 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
L
LAL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|364106.8.peg.1966
Escherichia coli UTI89 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
L
LAL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|331111.12.peg.2227
Escherichia coli E24377A (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
IG
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
A
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|331111.3.peg.4372
Escherichia coli E24377A (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
IG
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
A
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|340184.3.peg.4144
Escherichia coli B7A (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
IG
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|340184.6.peg.4342
Escherichia coli B7A (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
IG
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|595495.4.peg.2389
Escherichia coli KO11 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
IG
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|679204.3.peg.657
Escherichia coli MS 145-7 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
IG
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|566546.3.peg.912
Escherichia coli W (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
IG
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|566546.4.peg.1885
Escherichia coli W (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
IG
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|550677.3.peg.1220
Escherichia coli B354 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
PM
D
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|562.371.peg.4585
Escherichia coli 1044A (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
I
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|83334.1.peg.2461
Escherichia coli O157:H7 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
I
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|155864.1.peg.2470
Escherichia coli O157:H7 EDL933 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
I
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|155864.8.peg.2318
Escherichia coli O157:H7 EDL933 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
I
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|478006.5.peg.2663
Escherichia coli O157:H7 str. EC4501 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
I
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|386585.9.peg.2549
Escherichia coli O157:H7 str. Sakai (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
I
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|502346.5.peg.4965
Escherichia coli O157:H7 str. TW14588 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
I
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|562.373.peg.5487
Escherichia coli 1125A (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|562.372.peg.4817
Escherichia coli 1212A (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|670888.3.peg.230
Escherichia coli 1827-70 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|562.374.peg.4295
Escherichia coli 536A (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|481805.3.peg.2052
Escherichia coli ATCC 8739 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|481805.6.peg.2048
Escherichia coli ATCC 8739 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|413997.3.peg.1776
Escherichia coli B str. REL606 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|550676.3.peg.2040
Escherichia coli B185 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|511693.5.peg.1804
Escherichia coli BL21 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|469008.4.peg.1974
Escherichia coli BL21(DE3) (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|749537.3.peg.1464
Escherichia coli MS 115-1 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|749547.3.peg.2955
Escherichia coli MS 187-1 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|444454.5.peg.1182
Escherichia coli O157:H7 str. EC4024 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|444449.5.peg.670
Escherichia coli O157:H7 str. EC4042 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|444448.5.peg.4974
Escherichia coli O157:H7 str. EC4045 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|444453.5.peg.3528
Escherichia coli O157:H7 str. EC4076 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|444452.5.peg.2459
Escherichia coli O157:H7 str. EC4113 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|444450.8.peg.2485
Escherichia coli O157:H7 str. EC4115 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|444451.5.peg.2597
Escherichia coli O157:H7 str. EC4196 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|444447.5.peg.5014
Escherichia coli O157:H7 str. EC4206 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|478004.5.peg.3433
Escherichia coli O157:H7 str. EC4401 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|478005.5.peg.4286
Escherichia coli O157:H7 str. EC4486 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|478007.5.peg.2782
Escherichia coli O157:H7 str. EC508 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|478008.5.peg.3325
Escherichia coli O157:H7 str. EC869 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|637388.3.peg.4863
Escherichia coli O157:H7 str. FRIK2000 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|570506.3.peg.3942
Escherichia coli O157:H7 str. FRIK966 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|544404.4.peg.2347
Escherichia coli O157:H7 str. TW14359 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|701177.3.peg.2177
Escherichia coli O55:H7 str. CB9615 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|585397.7.peg.1956
Escherichia coli ED1a (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|585397.9.peg.1951
Escherichia coli ED1a (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|362663.8.peg.1693
Escherichia coli 536 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|362663.9.peg.1697
Escherichia coli 536 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|525281.3.peg.772
Escherichia coli 83972 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|655817.3.peg.2079
Escherichia coli ABU 83972 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|199310.1.peg.2065
Escherichia coli CFT073 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|199310.4.peg.1994
Escherichia coli CFT073 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|340197.3.peg.1814
Escherichia coli F11 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|340197.5.peg.1911
Escherichia coli F11 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|656417.3.peg.2234
Escherichia coli M605 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|749546.3.peg.4480
Escherichia coli MS 185-1 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|749550.3.peg.3136
Escherichia coli MS 200-1 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|749528.3.peg.4802
Escherichia coli MS 45-1 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|753642.3.peg.3232
Escherichia coli NC101 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|685038.3.peg.1746
Escherichia coli O83:H1 str. NRG 857C (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|431946.3.peg.1651
Escherichia coli SE15 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|656440.3.peg.1648
Escherichia coli TA206 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|562.376.peg.2387
Escherichia coli WV_060327 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|550672.3.peg.2575
Escherichia coli B088 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|585034.4.peg.1766
Escherichia coli IAI1 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|585034.5.peg.1761
Escherichia coli IAI1 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|679205.4.peg.2494
Escherichia coli MS 124-1 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|749533.3.peg.2689
Escherichia coli MS 84-1 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|585396.4.peg.2324
Escherichia coli O111:H- str. 11128 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|573235.3.peg.2541
Escherichia coli O26:H11 str. 11368 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|670897.3.peg.2612
Escherichia coli 2362-75 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|1040638.4.peg.3792
Escherichia coli O104:H4 str. LB226692 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
T
FL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|6666666.5357.peg.859
Escherichia coli TY-2482 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
T
FL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|585055.6.peg.1926
Escherichia coli 55989 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
T
FL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|585055.8.peg.1929
Escherichia coli 55989 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
T
FL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|562.375.peg.1842
Escherichia coli EC4100B (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
T
FL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|656408.3.peg.1888
Escherichia coli H591 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
T
FL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|679206.4.peg.1161
Escherichia coli MS 119-7 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
T
FL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|749545.3.peg.2828
Escherichia coli MS 182-1 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
T
FL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|749532.3.peg.2216
Escherichia coli MS 78-1 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
T
FL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|409438.11.peg.2045
Escherichia coli SE11 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
T
FL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|656443.3.peg.2402
Escherichia coli TA271 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
T
FL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|656419.3.peg.2444
Escherichia coli M718 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
T
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|358709.5.peg.3229
Escherichia coli 101-1 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
E
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|344601.3.peg.2845
Escherichia coli B171 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|344601.5.peg.2964
Escherichia coli B171 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|340186.3.peg.2135
Escherichia coli E110019 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|340186.5.peg.2202
Escherichia coli E110019 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|340185.3.peg.4157
Escherichia coli E22 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|340185.4.peg.4384
Escherichia coli E22 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|679207.4.peg.3322
Escherichia coli MS 107-1 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|585395.4.peg.2014
Escherichia coli O103:H2 str. 12009 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|344610.3.peg.2415
Escherichia coli 53638 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|344610.7.peg.5383
Escherichia coli 53638 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|595496.3.peg.1690
Escherichia coli BW2952 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|536056.3.peg.2024
Escherichia coli DH1 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|316401.4.peg.2021
Escherichia coli ETEC H10407 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|656414.3.peg.2050
Escherichia coli H736 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|331112.3.peg.1703
Escherichia coli HS (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|331112.6.peg.1771
Escherichia coli HS (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|83333.1.peg.1712
Escherichia coli K12 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|749538.3.peg.4333
Escherichia coli MS 116-1 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|749548.3.peg.2515
Escherichia coli MS 196-1 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|316407.3.peg.1684
Escherichia coli W3110 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|316385.5.peg.1843
Escherichia coli str. K-12 substr. DH10B (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|316385.7.peg.1888
Escherichia coli str. K-12 substr. DH10B (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|511145.12.peg.1800
Escherichia coli str. K-12 substr. MG1655 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|511145.6.peg.1785
Escherichia coli str. K-12 substr. MG1655 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|749540.3.peg.4145
Escherichia coli MS 146-1 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
A
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
I
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TG
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
G
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|216593.1.peg.553
Escherichia coli E2348/69 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
D
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
fig|574521.7.peg.1899
Escherichia coli O127:H6 str. E2348/69 (68-453/463)
V
G
N
G
Y
V
Q
L
LQ
MIV
M
P
L
VF
A
S
I
L
S
AV
A
R
L
H
N
A
S
QLG
K
I
SF
L
TI
G
TLL
FT
T
L
IA
A
L
V
G
V
L
V
T
N
L
F
GLTAEGLV
Q
G
GA
-
--
-
E
T
A
R
L
N
A
IE-
S
N
Y
-----
V
G
K
V
SD
L
SV
PQL
V
LS
F
IP
K
N
PF
A
DL
T
G
A
N
PTS
I
I
S
V
V
I
FA
AFL
G
V
A
A
LK
L
LKD
D
A
P
KGE
R
V
L
T
A
I
D
T
L
Q
SW
V
M
K
L
VR
L
VM
Q
L
T
P
Y
GV
L
ALM
T
K
V
VA
GS
N
LQD
I
IK
LG
S
F
V
V
AS
Y
LG-
LL
I
MFA
V
H
G
L
L
L
GIN
G
V
S
PL
K
Y
F
R
K
V
WP
V
L
TF
A
FT
S
R
SS
AA
S
I
P
L
N
V
E
AQTR
R
LG
V
P
E
SI
A
SF
A
A
SF
G
ATIGQN
G
C
A
G
LY
P
A
M
L
AV
MV
A
P
TV
GI
N
P
LD
P
MWI
A
TLV
GI
V
T
VSS
A
G
V
AGV
G
G
GA
T
F
AA
L
IV
L
P
A
M
D
-
LPV
T
LV
AL
L
I
S
V
EP
L
I
DM
G
RTALNV
S
G
S
MT
A
GT
L
T
SQ
W
L
K
Q
T
D
K
AI
LD
Consen1
Primary consensus
lsP
Gdgfv
LikMIv
Pivf
tlv
giAgv
dakqlGriga
ti
yfe
ttiA
iiGi
l
Nvf
--------
QpGAg
--
vd
a
L
a
s
Y
-----
a
q
sd
gi
ils
iP
n
a
a
gn
---
il
vi
FavlfG
al
L
---
a
kge
l
tvi
s
s
mfkv
mvMrlaP
Gvfalma
tva
g
l
Lg
lvl
y
llf
VlG
va
G
S
k
iR
l
eL
a
t
SSes
lPr
ie
-
kme
lG
p
Si
sfv
ptGysfnldG
t
-
lY
smaAvfiAq
gi
-
ldi
itLv
l
vsSkG
AGV
G
f
vllatL
avG
-
lPv
glAli
gvdr
ldmaRtalNvvGn
A
v
akW
kk
D
kkLDDvLNNRAPDGKTHELSS
Consen2
Secondary consensus
mk
niyi
lq
i
ii
s
l
av
r
msav
ktsf
al
tll
slv
l
lvgltaeglv
g
-
mn
-
e
s
t
a
qsttev
k
ks
sv
vmd
v
s
g
t
aeptsmi
i
safl
ga
lkd
g
hrq
naf
t
q
mg
li
qyt
algait
vig
n
i
a
fi
h
ifi
h
l
i
f
v
v
s
aa
i
l
daqtr
y
r
v
gla
sf
atigqn
gi
il
imv
p
ns
pmsp
ai
l
v
lt
a
t
aaaiv
sm
hi
l
lv
fl
siep
seg
alt
ls
s
l
sq
h
ai
a
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character