fig|550676.3.peg.3653
Escherichia coli B185 (1-489/490)
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|1040638.4.peg.2121
Escherichia coli O104:H4 str. LB226692
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|6666666.5357.peg.4125
Escherichia coli TY-2482
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|358709.5.peg.320
Escherichia coli 101-1
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|585055.6.peg.3966
Escherichia coli 55989
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|585055.8.peg.3968
Escherichia coli 55989
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|413997.3.peg.3505
Escherichia coli B str. REL606
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|340184.3.peg.362
Escherichia coli B7A
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|340184.6.peg.378
Escherichia coli B7A
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|511693.5.peg.3521
Escherichia coli BL21
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|469008.4.peg.259
Escherichia coli BL21(DE3)
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|340186.3.peg.1625
Escherichia coli E110019
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|340186.5.peg.1675
Escherichia coli E110019
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|331111.12.peg.4218
Escherichia coli E24377A
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|331111.3.peg.1632
Escherichia coli E24377A
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|562.375.peg.4851
Escherichia coli EC4100B
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|656408.3.peg.3921
Escherichia coli H591
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|595495.4.peg.1409
Escherichia coli KO11
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|679206.4.peg.2470
Escherichia coli MS 119-7
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|679204.3.peg.4585
Escherichia coli MS 145-7
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|749547.3.peg.1970
Escherichia coli MS 187-1
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|749533.3.peg.5088
Escherichia coli MS 84-1
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|585396.4.peg.4453
Escherichia coli O111:H- str. 11128
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|573235.3.peg.4697
Escherichia coli O26:H11 str. 11368
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|656443.3.peg.4399
Escherichia coli TA271
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|566546.3.peg.1972
Escherichia coli W
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|566546.4.peg.3713
Escherichia coli W
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|670888.3.peg.2748
Escherichia coli 1827-70
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|344610.3.peg.107
Escherichia coli 53638
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|344610.7.peg.2733
Escherichia coli 53638
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|481805.3.peg.229
Escherichia coli ATCC 8739
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|481805.6.peg.238
Escherichia coli ATCC 8739
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|344601.3.peg.1334
Escherichia coli B171
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|344601.5.peg.1404
Escherichia coli B171
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|595496.3.peg.3479
Escherichia coli BW2952
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|536056.3.peg.228
Escherichia coli DH1
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|340185.3.peg.107
Escherichia coli E22
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|340185.4.peg.118
Escherichia coli E22
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|656414.3.peg.3989
Escherichia coli H736
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|331112.3.peg.3465
Escherichia coli HS
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|331112.6.peg.3604
Escherichia coli HS
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|585034.4.peg.3563
Escherichia coli IAI1
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|585034.5.peg.3561
Escherichia coli IAI1
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|83333.1.peg.3429
Escherichia coli K12
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|749538.3.peg.4026
Escherichia coli MS 116-1
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|749540.3.peg.1978
Escherichia coli MS 146-1
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|749544.3.peg.3000
Escherichia coli MS 175-1
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|749545.3.peg.4601
Escherichia coli MS 182-1
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|749548.3.peg.3939
Escherichia coli MS 196-1
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|749532.3.peg.3866
Escherichia coli MS 78-1
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|585395.4.peg.4412
Escherichia coli O103:H2 str. 12009
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|409438.11.peg.3933
Escherichia coli SE11
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|316407.3.peg.3633
Escherichia coli W3110
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|316385.7.peg.3699
Escherichia coli str. K-12 substr. DH10B
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|511145.12.peg.3598
Escherichia coli str. K-12 substr. MG1655
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|511145.6.peg.3581
Escherichia coli str. K-12 substr. MG1655
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|749527.3.peg.2682
Escherichia coli MS 21-1 (1-489/490)
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|216592.1.peg.746
Escherichia coli 042
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SDPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|216592.3.peg.3924
Escherichia coli 042
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SDPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|550677.3.peg.4046
Escherichia coli B354
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|656379.3.peg.4798
Escherichia coli FVEC1302
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|656380.3.peg.4587
Escherichia coli FVEC1412
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|656393.3.peg.4554
Escherichia coli H299
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|749549.3.peg.2748
Escherichia coli MS 198-1
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|749531.3.peg.1599
Escherichia coli MS 69-1
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|656437.3.peg.3920
Escherichia coli TA143
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SDPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|585056.7.peg.4155
Escherichia coli UMN026
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|562.376.peg.2760
Escherichia coli WV_060327
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
QD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
M
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|656444.3.peg.4769
Escherichia coli TA280
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LI
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|362663.8.peg.3618
Escherichia coli 536
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|362663.9.peg.3630
Escherichia coli 536
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|525281.3.peg.2938
Escherichia coli 83972
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|655817.3.peg.4097
Escherichia coli ABU 83972
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|405955.13.peg.3929
Escherichia coli APEC O1
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|405955.9.peg.3289
Escherichia coli APEC O1
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|199310.1.peg.4200
Escherichia coli CFT073
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|199310.4.peg.4034
Escherichia coli CFT073
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|585397.7.peg.4154
Escherichia coli ED1a
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|585397.9.peg.4150
Escherichia coli ED1a
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|316401.4.peg.4242
Escherichia coli ETEC H10407
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|340197.3.peg.675
Escherichia coli F11
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|340197.5.peg.703
Escherichia coli F11
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|714962.3.peg.3961
Escherichia coli IHE3034
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|656417.3.peg.4354
Escherichia coli M605
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|749528.3.peg.3026
Escherichia coli MS 45-1
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|701177.3.peg.4241
Escherichia coli O55:H7 str. CB9615
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|685038.3.peg.3539
Escherichia coli O83:H1 str. NRG 857C
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|585035.6.peg.3824
Escherichia coli S88
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|431946.3.peg.3457
Escherichia coli SE15
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|656440.3.peg.3748
Escherichia coli TA206
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|869729.3.peg.3766
Escherichia coli UM146
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|364106.7.peg.3929
Escherichia coli UTI89
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|364106.8.peg.3930
Escherichia coli UTI89
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|753642.3.peg.4452
Escherichia coli NC101
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
M
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|562.371.peg.3332
Escherichia coli 1044A
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
T
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|562.373.peg.1745
Escherichia coli 1125A
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
T
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|562.372.peg.4214
Escherichia coli 1212A
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
T
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|562.374.peg.5102
Escherichia coli 536A
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
T
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|83334.1.peg.4338
Escherichia coli O157:H7
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
T
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|155864.1.peg.4375
Escherichia coli O157:H7 EDL933
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
T
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|444454.5.peg.3448
Escherichia coli O157:H7 str. EC4024
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
T
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|444449.5.peg.2904
Escherichia coli O157:H7 str. EC4042
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
T
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|444448.5.peg.1657
Escherichia coli O157:H7 str. EC4045
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
T
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|444453.5.peg.1188
Escherichia coli O157:H7 str. EC4076
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
T
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|444452.5.peg.154
Escherichia coli O157:H7 str. EC4113
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
T
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|444450.8.peg.4738
Escherichia coli O157:H7 str. EC4115
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
T
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|444451.5.peg.328
Escherichia coli O157:H7 str. EC4196
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
T
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|444447.5.peg.1819
Escherichia coli O157:H7 str. EC4206
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
T
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|478004.5.peg.214
Escherichia coli O157:H7 str. EC4401
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
T
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|478006.5.peg.178
Escherichia coli O157:H7 str. EC4501
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
T
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|478007.5.peg.186
Escherichia coli O157:H7 str. EC508
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
T
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|478008.5.peg.707
Escherichia coli O157:H7 str. EC869
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
T
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|637388.3.peg.1899
Escherichia coli O157:H7 str. FRIK2000
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
T
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|570506.3.peg.121
Escherichia coli O157:H7 str. FRIK966
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
T
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|386585.9.peg.4562
Escherichia coli O157:H7 str. Sakai
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
T
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|544404.4.peg.4549
Escherichia coli O157:H7 str. TW14359
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
T
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|502346.5.peg.2281
Escherichia coli O157:H7 str. TW14588
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
T
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|656419.3.peg.4496
Escherichia coli M718
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|585057.4.peg.4117
Escherichia coli IAI39
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
C
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|585057.6.peg.4125
Escherichia coli IAI39
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
C
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|439855.10.peg.3931
Escherichia coli SMS-3-5
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
C
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|155864.8.peg.4320
Escherichia coli O157:H7 EDL933
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
T
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
X
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|670897.3.peg.3864
Escherichia coli 2362-75
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
C
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|216593.1.peg.4216
Escherichia coli E2348/69
MNTTTPM
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
L
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
C
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|679207.4.peg.311
Escherichia coli MS 107-1
M
GMLQ
QPR
PFF
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
T
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|749537.3.peg.414
Escherichia coli MS 115-1
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DR
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
K
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|749546.3.peg.3968
Escherichia coli MS 185-1
M
I
F
F
V
EL
WE
R
F
GY
YG
V
QG
V
L
AVFFV
K
QLG
F
S
Q
EQ
A
FV
T
F
G
A
F
A
A
LVY
GL
IS
I
GG
Y
VG
D
H
L
LG
TK
RT
I
V
LGAL
VL
AIG
Y
F
M
T
G
M
S
LLKPDL
I
F
I
A
L
G
T
I
A
V
G
N
GLFK
A
N
P
AS
LL
S
K
C
Y
PPK
DPR
L
DG
A
F
T
L
F
Y
MS
I
NIGS
LI
A
L
SL
A
P
VI
A
DK
F
G
Y
S
V
T
Y
N
L
CGA
G
L
I
I
A
L
L
V
Y
I-
-
-
---
-A
C
R
GMV
K
DI
G
SEPD
F
R
P
MS
F
SK
LL
YV
L
LGS
VV
M
I
F
V
CA
W
L
M
HN
V
E
VA
NLV
L
I
V
LSIVVTI
I
FF
R
QAF
K
LD
-
KTG
R
NK
M
FV
AF
V
LM
L
EAV
V
F
Y
I
L
Y
A
Q
MPT
S
LNF
F
AINN
V
H
H
EI
L
G
FS
I
N
P
VS
FQ
A
LN
P
F
W
V
V
L
A
SP
I
LA
G
I
YTHLGNKGKD
L
S
M
P
M
KF
T
L
G
M
F
MC
S
L
GF
LT
AA
AAG
M
WF
A
DAQ
G
LT
S
PWF
I
V
LV
Y
LF
QS
L
G
ELFI
S
A
LG
LA
M
I
A
A
L
VPQHLM
G
FI
L
G
M
WF
L
-
T
Q
A
A
A
F
L
L
G
G
Y
VA
TFT
AVP
D
N
I
TD
PL-
--
--
---
E
T
L
P
VY
TN
VF
G
K
IG
LV
TL
GV
A
V
V
MLL
MVPW
L
K
RMIATPESH
fig|331112.3.peg.1610
Escherichia coli HS (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
T
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
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I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|331112.6.peg.1677
Escherichia coli HS (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
T
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|409438.11.peg.1903
Escherichia coli SE11 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVI
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|216592.3.peg.1873
Escherichia coli 042 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|358709.5.peg.1149
Escherichia coli 101-1 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
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I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|670888.3.peg.128
Escherichia coli 1827-70 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|344610.3.peg.3151
Escherichia coli 53638 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
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I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|344610.7.peg.5282
Escherichia coli 53638 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|481805.3.peg.2152
Escherichia coli ATCC 8739 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|481805.6.peg.2145
Escherichia coli ATCC 8739 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|413997.3.peg.1678
Escherichia coli B str. REL606 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|511693.5.peg.1704
Escherichia coli BL21 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|469008.4.peg.2071
Escherichia coli BL21(DE3) (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|595496.3.peg.1594
Escherichia coli BW2952 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|536056.3.peg.2120
Escherichia coli DH1 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|316401.4.peg.1917
Escherichia coli ETEC H10407 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|656379.3.peg.2103
Escherichia coli FVEC1302 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|656380.3.peg.3069
Escherichia coli FVEC1412 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|656393.3.peg.2425
Escherichia coli H299 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|656414.3.peg.1945
Escherichia coli H736 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|83333.1.peg.1620
Escherichia coli K12 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|749538.3.peg.4303
Escherichia coli MS 116-1 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|679205.4.peg.1669
Escherichia coli MS 124-1 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|749540.3.peg.4275
Escherichia coli MS 146-1 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|749547.3.peg.3060
Escherichia coli MS 187-1 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|749548.3.peg.3436
Escherichia coli MS 196-1 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|749527.3.peg.3580
Escherichia coli MS 21-1 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|749531.3.peg.4874
Escherichia coli MS 69-1 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|749533.3.peg.2422
Escherichia coli MS 84-1 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|656437.3.peg.1847
Escherichia coli TA143 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|585056.7.peg.2108
Escherichia coli UMN026 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|316407.3.peg.1592
Escherichia coli W3110 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|316385.7.peg.1791
Escherichia coli str. K-12 substr. DH10B (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|511145.12.peg.1705
Escherichia coli str. K-12 substr. MG1655 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|511145.6.peg.1689
Escherichia coli str. K-12 substr. MG1655 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|344601.3.peg.379
Escherichia coli B171 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|344601.5.peg.377
Escherichia coli B171 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|340184.3.peg.968
Escherichia coli B7A (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|340184.6.peg.1003
Escherichia coli B7A (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|340186.3.peg.3461
Escherichia coli E110019 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|340186.5.peg.3614
Escherichia coli E110019 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|340185.3.peg.3320
Escherichia coli E22 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|340185.4.peg.3496
Escherichia coli E22 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|331111.12.peg.2129
Escherichia coli E24377A (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|331111.3.peg.4271
Escherichia coli E24377A (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|562.375.peg.1738
Escherichia coli EC4100B (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|656408.3.peg.1779
Escherichia coli H591 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|585034.4.peg.1668
Escherichia coli IAI1 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|585034.5.peg.1663
Escherichia coli IAI1 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|679207.4.peg.4249
Escherichia coli MS 107-1 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|749537.3.peg.1708
Escherichia coli MS 115-1 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|679206.4.peg.1264
Escherichia coli MS 119-7 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|679204.3.peg.552
Escherichia coli MS 145-7 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|749545.3.peg.2662
Escherichia coli MS 182-1 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|749532.3.peg.1488
Escherichia coli MS 78-1 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|585395.4.peg.1857
Escherichia coli O103:H2 str. 12009 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|585396.4.peg.2185
Escherichia coli O111:H- str. 11128 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|573235.3.peg.2399
Escherichia coli O26:H11 str. 11368 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|656443.3.peg.2288
Escherichia coli TA271 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|566546.3.peg.1016
Escherichia coli W (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|566546.4.peg.1789
Escherichia coli W (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|1040638.4.peg.3685
Escherichia coli O104:H4 str. LB226692 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AN
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|6666666.5357.peg.4693
Escherichia coli TY-2482 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AN
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|585055.6.peg.1829
Escherichia coli 55989 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AN
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|585055.8.peg.1833
Escherichia coli 55989 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AN
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
II
A
V
LMLL
TAPK
L
H
RM
fig|562.371.peg.4483
Escherichia coli 1044A (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|562.372.peg.4716
Escherichia coli 1212A (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|562.374.peg.4396
Escherichia coli 536A (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|550676.3.peg.1939
Escherichia coli B185 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|550677.3.peg.3019
Escherichia coli B354 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|585057.4.peg.1489
Escherichia coli IAI39 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|585057.6.peg.1488
Escherichia coli IAI39 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|83334.1.peg.2369
Escherichia coli O157:H7 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|155864.1.peg.2378
Escherichia coli O157:H7 EDL933 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|155864.8.peg.2220
Escherichia coli O157:H7 EDL933 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|478006.5.peg.4037
Escherichia coli O157:H7 str. EC4501 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|478008.5.peg.4546
Escherichia coli O157:H7 str. EC869 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|637388.3.peg.5007
Escherichia coli O157:H7 str. FRIK2000 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|570506.3.peg.4226
Escherichia coli O157:H7 str. FRIK966 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|386585.9.peg.2452
Escherichia coli O157:H7 str. Sakai (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|502346.5.peg.5062
Escherichia coli O157:H7 str. TW14588 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|701177.3.peg.2026
Escherichia coli O55:H7 str. CB9615 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|656444.3.peg.2530
Escherichia coli TA280 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|562.373.peg.5385
Escherichia coli 1125A (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QN
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|444454.5.peg.5621
Escherichia coli O157:H7 str. EC4024 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QN
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|444449.5.peg.567
Escherichia coli O157:H7 str. EC4042 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QN
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|444448.5.peg.4875
Escherichia coli O157:H7 str. EC4045 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QN
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|444453.5.peg.4739
Escherichia coli O157:H7 str. EC4076 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QN
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|444452.5.peg.3487
Escherichia coli O157:H7 str. EC4113 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QN
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|444450.8.peg.2386
Escherichia coli O157:H7 str. EC4115 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QN
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|444451.5.peg.3406
Escherichia coli O157:H7 str. EC4196 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QN
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|444447.5.peg.5113
Escherichia coli O157:H7 str. EC4206 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QN
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|478004.5.peg.4098
Escherichia coli O157:H7 str. EC4401 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QN
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|478007.5.peg.3551
Escherichia coli O157:H7 str. EC508 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QN
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|544404.4.peg.2249
Escherichia coli O157:H7 str. TW14359 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QN
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|670897.3.peg.2283
Escherichia coli 2362-75 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|362663.8.peg.1593
Escherichia coli 536 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|362663.9.peg.1597
Escherichia coli 536 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|525281.3.peg.872
Escherichia coli 83972 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|655817.3.peg.1972
Escherichia coli ABU 83972 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|405955.13.peg.1717
Escherichia coli APEC O1 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|405955.9.peg.1401
Escherichia coli APEC O1 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|199310.1.peg.1964
Escherichia coli CFT073 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|199310.4.peg.1893
Escherichia coli CFT073 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|585397.7.peg.1852
Escherichia coli ED1a (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|585397.9.peg.1847
Escherichia coli ED1a (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|340197.3.peg.3563
Escherichia coli F11 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|340197.5.peg.3725
Escherichia coli F11 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|714962.3.peg.1785
Escherichia coli IHE3034 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|656419.3.peg.2342
Escherichia coli M718 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|749546.3.peg.4589
Escherichia coli MS 185-1 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|749550.3.peg.3243
Escherichia coli MS 200-1 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|749528.3.peg.4909
Escherichia coli MS 45-1 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|753642.3.peg.1527
Escherichia coli NC101 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|685038.3.peg.1651
Escherichia coli O83:H1 str. NRG 857C (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|585035.6.peg.1672
Escherichia coli S88 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|431946.3.peg.1553
Escherichia coli SE15 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|869729.3.peg.1909
Escherichia coli UM146 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|364106.7.peg.1864
Escherichia coli UTI89 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|364106.8.peg.1867
Escherichia coli UTI89 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|562.376.peg.2919
Escherichia coli WV_060327 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|216592.1.peg.2240
Escherichia coli 042 (1-472/487)
M
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|749549.3.peg.5246
Escherichia coli MS 198-1 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
G
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
SI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LMLL
TAPK
L
H
RM
fig|656417.3.peg.2129
Escherichia coli M605 (11-485/500)
SVSL
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
Y
RM
fig|216593.1.peg.406
Escherichia coli E2348/69 (1-472/487)
M
NAFK
QP
K
A
F
Y
L
I
F
S
I
EL
WE
R
F
GY
YG
L
QG
I
MAV
YL
V
K
QLG
M
S
E
AD
S
IT
LFS
SF
S
A
LVY
GL
VA
I
GGWL
G
D
K
VLG
TK
RV
I
MLGA
IVL
AIG
Y
A
L
V
A
W
S
GHDAGI
V
Y
M
G
M
A
A
I
A
V
G
N
GLFK
A
N
P
S
S
LL
S
T
C
Y
EKN
DPR
L
DG
A
F
TM
Y
Y
MS
V
NIGS
FF
S
M
IA
T
P
WL
A
AK
YGW
S
V
A
F
A
L
SVV
G
L
L
I
T
I
V
N
F
A-
-
-
---
-F
CQ
RWV
K
QY
G
SKPD
F
E
P
IN
Y
RN
LL
LT
I
IGV
V
A
L
I
A
I
AT
W
L
L
HN
Q
E
VA
RMA
L
G
V
VAFGIVV
I
FG
K
EAF
A
MK
-
GAA
R
RK
M
IV
AF
I
LM
L
EAI
I
F
F
V
L
Y
S
Q
MPT
S
LNF
F
AI
R
N
V
E
H
TI
L
G
LA
V
E
P
EQ
Y
Q
A
LN
P
F
WI
I
I
G
SP
I
LA
A
I
YNKMGDT---
L
P
M
P
T
KFA
I
G
M
V
MC
S
G
A
F
LI
-
L
PLG
A
KF
A
SDA
G
IV
S
VSW
L
V
AS
Y
GL
QS
I
G
EL
M
I
S
G
LG
LA
MVA
Q
L
VPQRLM
G
FI
M
G
S
WF
L
-
T
T
A
G
AN
L
IG
G
Y
VA
GMM
AVP
D
N
V
TD
PL-
--
--
---
M
S
L
E
VY
GR
VF
L
QIG
VA
T
A
VI
A
V
LML
F
TAPK
L
H
RM
fig|670897.3.peg.859
Escherichia coli 2362-75 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DI
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|216593.1.peg.2919
Escherichia coli E2348/69 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DI
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|585397.7.peg.686
Escherichia coli ED1a (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DI
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|585397.9.peg.688
Escherichia coli ED1a (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DI
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|574521.7.peg.636
Escherichia coli O127:H6 str. E2348/69 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DI
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|656440.3.peg.562
Escherichia coli TA206 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DI
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
M
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|585057.4.peg.708
Escherichia coli IAI39 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
SH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|585057.6.peg.705
Escherichia coli IAI39 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
SH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|525281.3.peg.2240
Escherichia coli 83972 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|655817.3.peg.795
Escherichia coli ABU 83972 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|405955.13.peg.675
Escherichia coli APEC O1 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|405955.9.peg.560
Escherichia coli APEC O1 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|199310.1.peg.761
Escherichia coli CFT073 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|199310.4.peg.752
Escherichia coli CFT073 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|714962.3.peg.723
Escherichia coli IHE3034 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|656417.3.peg.835
Escherichia coli M605 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|749546.3.peg.167
Escherichia coli MS 185-1 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|749528.3.peg.3933
Escherichia coli MS 45-1 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|753642.3.peg.952
Escherichia coli NC101 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|685038.3.peg.640
Escherichia coli O83:H1 str. NRG 857C (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|585035.6.peg.734
Escherichia coli S88 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|431946.3.peg.667
Escherichia coli SE15 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|869729.3.peg.3001
Escherichia coli UM146 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|364106.7.peg.804
Escherichia coli UTI89 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|364106.8.peg.803
Escherichia coli UTI89 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|562.376.peg.1917
Escherichia coli WV_060327 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|570506.3.peg.431
Escherichia coli O157:H7 str. FRIK966 (7-478/493)
QPR
S
IY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|481805.3.peg.3158
Escherichia coli ATCC 8739 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DI
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|481805.6.peg.3143
Escherichia coli ATCC 8739 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DI
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|331111.12.peg.1030
Escherichia coli E24377A (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QG
R
SSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|331111.3.peg.3249
Escherichia coli E24377A (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QG
R
SSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|701177.3.peg.861
Escherichia coli O55:H7 str. CB9615 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
M
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|155864.1.peg.732
Escherichia coli O157:H7 EDL933 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPX
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|155864.8.peg.754
Escherichia coli O157:H7 EDL933 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPX
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|1040638.4.peg.5056
Escherichia coli O104:H4 str. LB226692 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|6666666.5357.peg.2124
Escherichia coli TY-2482 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|585055.6.peg.705
Escherichia coli 55989 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|585055.8.peg.707
Escherichia coli 55989 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|550676.3.peg.165
Escherichia coli B185 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|656408.3.peg.651
Escherichia coli H591 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|585034.4.peg.679
Escherichia coli IAI1 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|585034.5.peg.678
Escherichia coli IAI1 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|679207.4.peg.1363
Escherichia coli MS 107-1 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|749537.3.peg.2048
Escherichia coli MS 115-1 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|679206.4.peg.2782
Escherichia coli MS 119-7 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|749532.3.peg.2581
Escherichia coli MS 78-1 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|585396.4.peg.757
Escherichia coli O111:H- str. 11128 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|573235.3.peg.784
Escherichia coli O26:H11 str. 11368 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|409438.11.peg.894
Escherichia coli SE11 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|562.371.peg.574
Escherichia coli 1044A (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|562.373.peg.3024
Escherichia coli 1125A (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|562.372.peg.1702
Escherichia coli 1212A (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|562.374.peg.5275
Escherichia coli 536A (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|83334.1.peg.805
Escherichia coli O157:H7 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|444454.5.peg.5227
Escherichia coli O157:H7 str. EC4024 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|444449.5.peg.5563
Escherichia coli O157:H7 str. EC4042 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|444448.5.peg.3438
Escherichia coli O157:H7 str. EC4045 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|444453.5.peg.781
Escherichia coli O157:H7 str. EC4076 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|444452.5.peg.3565
Escherichia coli O157:H7 str. EC4113 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|444450.8.peg.897
Escherichia coli O157:H7 str. EC4115 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|444451.5.peg.4509
Escherichia coli O157:H7 str. EC4196 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|444447.5.peg.3618
Escherichia coli O157:H7 str. EC4206 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|478004.5.peg.3842
Escherichia coli O157:H7 str. EC4401 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|478005.5.peg.1285
Escherichia coli O157:H7 str. EC4486 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|478006.5.peg.4334
Escherichia coli O157:H7 str. EC4501 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|478007.5.peg.4001
Escherichia coli O157:H7 str. EC508 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|478008.5.peg.2127
Escherichia coli O157:H7 str. EC869 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|637388.3.peg.1486
Escherichia coli O157:H7 str. FRIK2000 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|386585.9.peg.850
Escherichia coli O157:H7 str. Sakai (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|544404.4.peg.762
Escherichia coli O157:H7 str. TW14359 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|502346.5.peg.457
Escherichia coli O157:H7 str. TW14588 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
RL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|656443.3.peg.972
Escherichia coli TA271 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KX
X
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|344601.3.peg.3398
Escherichia coli B171 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
SMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|344601.5.peg.3555
Escherichia coli B171 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
SMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|340185.3.peg.3897
Escherichia coli E22 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
SMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|340185.4.peg.4107
Escherichia coli E22 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
SMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|562.375.peg.1448
Escherichia coli EC4100B (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
SMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|585395.4.peg.743
Escherichia coli O103:H2 str. 12009 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
SMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|439855.10.peg.885
Escherichia coli SMS-3-5 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
SH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|656419.3.peg.982
Escherichia coli M718 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YK
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
C
HF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|344610.3.peg.4396
Escherichia coli 53638 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|344610.7.peg.977
Escherichia coli 53638 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|595496.3.peg.635
Escherichia coli BW2952 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|536056.3.peg.3088
Escherichia coli DH1 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|316401.4.peg.836
Escherichia coli ETEC H10407 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|331112.3.peg.703
Escherichia coli HS (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|331112.6.peg.734
Escherichia coli HS (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|83333.1.peg.701
Escherichia coli K12 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|749538.3.peg.662
Escherichia coli MS 116-1 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|749544.3.peg.3259
Escherichia coli MS 175-1 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|749548.3.peg.3235
Escherichia coli MS 196-1 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|316407.3.peg.683
Escherichia coli W3110 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|316385.7.peg.784
Escherichia coli str. K-12 substr. DH10B (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|511145.12.peg.739
Escherichia coli str. K-12 substr. MG1655 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|511145.6.peg.730
Escherichia coli str. K-12 substr. MG1655 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|656379.3.peg.1483
Escherichia coli FVEC1302 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
T
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|656380.3.peg.1311
Escherichia coli FVEC1412 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
T
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|585056.7.peg.991
Escherichia coli UMN026 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
T
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|340184.3.peg.2291
Escherichia coli B7A (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
Q
M
IWL
fig|340184.6.peg.2405
Escherichia coli B7A (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
Q
M
IWL
fig|679205.4.peg.3662
Escherichia coli MS 124-1 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
Q
M
IWL
fig|679204.3.peg.4485
Escherichia coli MS 145-7 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
Q
M
IWL
fig|749533.3.peg.4656
Escherichia coli MS 84-1 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
Q
M
IWL
fig|216592.1.peg.456
Escherichia coli 042 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|216592.3.peg.760
Escherichia coli 042 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|358709.5.peg.3974
Escherichia coli 101-1 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|670888.3.peg.1270
Escherichia coli 1827-70 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|413997.3.peg.711
Escherichia coli B str. REL606 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|550677.3.peg.1114
Escherichia coli B354 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|511693.5.peg.708
Escherichia coli BL21 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|469008.4.peg.3048
Escherichia coli BL21(DE3) (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|749547.3.peg.1746
Escherichia coli MS 187-1 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|749527.3.peg.2592
Escherichia coli MS 21-1 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|656437.3.peg.780
Escherichia coli TA143 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|656444.3.peg.1244
Escherichia coli TA280 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|656393.3.peg.1394
Escherichia coli H299 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|749531.3.peg.1857
Escherichia coli MS 69-1 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LY
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|749545.3.peg.3921
Escherichia coli MS 182-1 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
G
A
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|749549.3.peg.4472
Escherichia coli MS 198-1 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
G
A
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
T
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
VV
L
M
IWL
fig|362663.8.peg.734
Escherichia coli 536 (7-478/493)
QP
L
AIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|362663.9.peg.734
Escherichia coli 536 (7-478/493)
QP
L
AIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|340197.3.peg.4195
Escherichia coli F11 (7-478/493)
QP
L
AIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|340197.5.peg.4378
Escherichia coli F11 (7-478/493)
QP
L
AIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|749550.3.peg.4744
Escherichia coli MS 200-1 (7-478/493)
QP
L
AIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
SD
NH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
FA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|656414.3.peg.890
Escherichia coli H736 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
CE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|749540.3.peg.3806
Escherichia coli MS 146-1 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
CE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
I
LF
W
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|595495.4.peg.4368
Escherichia coli KO11 (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
R
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|566546.3.peg.5016
Escherichia coli W (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
R
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|566546.4.peg.763
Escherichia coli W (7-478/493)
QPRAIY
Y
V
V
A
L
QIWEYFSFYGMRALLILYLT
N
QL
K
Y
N
D
TH
A
YE
LFSAY
C
SLVYVT
PI
LGG
F
LAD
K
VLGNR
MA
VMLGALLMAIGH
V
V
L
G
A
S
EIHPSF
LYL
S
LA
I
I
V
CGYGLFKSN
V
SCLLG
E
LY
EPT
DPRRDGGFSL
M
YAA
G
N
V
GS
II
A
P
IA
C
G
YA
Q
EE
Y
S
W
A
M
G
F
G
L
AAV
GM
I
A
G
LV
I
F
LC
G
N
RHF
TH
TR
GVN
K
KV
L
RATN
F
L
L
PN
W
GW
LL
VL
L
VAT
PA
L
I
T
V
LF
R
-
-
--
K
EWS
VYA
L
I
V
ATIIGLG
V
LA
K
IYR
K
AE
N
QKQ
R
KE
L
GL
IV
T
L
T
F
FSM
LFW
A
F
A
Q
QGGSSISL
Y
IDRFV
N
R
DM
FG
YT
V
P
T
AM
FQS
I
NAFAVML
C
GV
F
LA
W
V
VKESVAGNRT
V
R
I
W
G
KFA
L
GL
G
LMS
A
GF
CI
-
L
TLS
A
RW
S
AMY
G
HS
S
LPL
MV
LG
L
AV
MG
F
AELFID
P
VA
M
S
QIT
R
I
EIPGVT
GVL
T
G
I
YML
L
S
G
A
I
AN
Y
LAGV
I
A
---
---
DQ
T
S
Q
ASF
DA
SG
AIN
Y
SI
N
A
Y
IE
VF
D
QI
T
WG
A
L
AC
V
G
L
V
L
M
IWL
fig|444454.5.peg.4195
Escherichia coli O157:H7 str. EC4024 (1-475/484)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
-
VA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|562.375.peg.2945
Escherichia coli EC4100B (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QT
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|749532.3.peg.4537
Escherichia coli MS 78-1 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QT
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|656444.3.peg.5591
Escherichia coli TA280 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
A
R
Y
LFS
TP
fig|562.371.peg.3650
Escherichia coli 1044A (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|562.373.peg.5753
Escherichia coli 1125A (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|562.372.peg.3408
Escherichia coli 1212A (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|344610.3.peg.1407
Escherichia coli 53638 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|344610.7.peg.1997
Escherichia coli 53638 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|562.374.peg.2743
Escherichia coli 536A (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|550676.3.peg.4406
Escherichia coli B185 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|83334.1.peg.5090
Escherichia coli O157:H7 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|155864.1.peg.5072
Escherichia coli O157:H7 EDL933 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|155864.8.peg.5055
Escherichia coli O157:H7 EDL933 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|444449.5.peg.3649
Escherichia coli O157:H7 str. EC4042 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|444448.5.peg.2407
Escherichia coli O157:H7 str. EC4045 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|444453.5.peg.2044
Escherichia coli O157:H7 str. EC4076 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|444452.5.peg.1120
Escherichia coli O157:H7 str. EC4113 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|444450.8.peg.5485
Escherichia coli O157:H7 str. EC4115 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|444451.5.peg.2148
Escherichia coli O157:H7 str. EC4196 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|444447.5.peg.2573
Escherichia coli O157:H7 str. EC4206 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|478005.5.peg.625
Escherichia coli O157:H7 str. EC4486 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|478006.5.peg.1510
Escherichia coli O157:H7 str. EC4501 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|478007.5.peg.1027
Escherichia coli O157:H7 str. EC508 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|478008.5.peg.158
Escherichia coli O157:H7 str. EC869 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|637388.3.peg.2371
Escherichia coli O157:H7 str. FRIK2000 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|570506.3.peg.1352
Escherichia coli O157:H7 str. FRIK966 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|386585.9.peg.5343
Escherichia coli O157:H7 str. Sakai (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|544404.4.peg.5297
Escherichia coli O157:H7 str. TW14359 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|502346.5.peg.1525
Escherichia coli O157:H7 str. TW14588 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|701177.3.peg.4963
Escherichia coli O55:H7 str. CB9615 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|550677.3.peg.127
Escherichia coli B354 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNTTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
VSPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
A
R
FLFS
TP
fig|656379.3.peg.505
Escherichia coli FVEC1302 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNTTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
VSPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
A
R
FLFS
TP
fig|656380.3.peg.497
Escherichia coli FVEC1412 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNTTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
VSPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
A
R
FLFS
TP
fig|749549.3.peg.1662
Escherichia coli MS 198-1 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNTTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
VSPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
A
R
FLFS
TP
fig|585056.7.peg.4828
Escherichia coli UMN026 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNTTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
VSPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
A
R
FLFS
TP
fig|749540.3.peg.1320
Escherichia coli MS 146-1 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LTFA
T
R
FLFS
TP
fig|753642.3.peg.4001
Escherichia coli NC101 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
A
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|685038.3.peg.4234
Escherichia coli O83:H1 str. NRG 857C (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
A
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|595496.3.peg.4206
Escherichia coli BW2952 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|536056.3.peg.4100
Escherichia coli DH1 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|340186.3.peg.1056
Escherichia coli E110019 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|340186.5.peg.1098
Escherichia coli E110019 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|316401.4.peg.5047
Escherichia coli ETEC H10407 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|656414.3.peg.4692
Escherichia coli H736 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|331112.3.peg.4085
Escherichia coli HS (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|331112.6.peg.4260
Escherichia coli HS (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|83333.1.peg.4042
Escherichia coli K12 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|595495.4.peg.4107
Escherichia coli KO11 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|679207.4.peg.3020
Escherichia coli MS 107-1 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|749537.3.peg.4275
Escherichia coli MS 115-1 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|679206.4.peg.992
Escherichia coli MS 119-7 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|749544.3.peg.115
Escherichia coli MS 175-1 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|749548.3.peg.3649
Escherichia coli MS 196-1 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|656443.3.peg.5118
Escherichia coli TA271 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|566546.3.peg.2177
Escherichia coli W (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|566546.4.peg.4428
Escherichia coli W (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|316407.3.peg.3968
Escherichia coli W3110 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|316385.5.peg.4276
Escherichia coli str. K-12 substr. DH10B (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|316385.7.peg.4366
Escherichia coli str. K-12 substr. DH10B (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|511145.12.peg.4262
Escherichia coli str. K-12 substr. MG1655 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|511145.6.peg.4241
Escherichia coli str. K-12 substr. MG1655 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|656437.3.peg.4642
Escherichia coli TA143 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNTTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
VSPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
A
R
FLFS
TP
fig|358709.5.peg.1882
Escherichia coli 101-1 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|413997.3.peg.4222
Escherichia coli B str. REL606 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|550672.3.peg.4481
Escherichia coli B088 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|340184.3.peg.700
Escherichia coli B7A (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|340184.6.peg.730
Escherichia coli B7A (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|511693.5.peg.4243
Escherichia coli BL21 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|469008.4.peg.4047
Escherichia coli BL21(DE3) (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|340185.3.peg.1424
Escherichia coli E22 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|340185.4.peg.1508
Escherichia coli E22 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|331111.12.peg.4894
Escherichia coli E24377A (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|331111.3.peg.2284
Escherichia coli E24377A (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|679205.4.peg.4508
Escherichia coli MS 124-1 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|679204.3.peg.3947
Escherichia coli MS 145-7 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|749533.3.peg.4398
Escherichia coli MS 84-1 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|585395.4.peg.5128
Escherichia coli O103:H2 str. 12009 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|344601.3.peg.1164
Escherichia coli B171 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
H
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|344601.5.peg.1228
Escherichia coli B171 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMV
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
H
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|749545.3.peg.2437
Escherichia coli MS 182-1 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
P
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QT
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|656419.3.peg.5379
Escherichia coli M718 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
L
T
W
L
ASPESHGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|216592.1.peg.2437
Escherichia coli 042 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|216592.3.peg.4668
Escherichia coli 042 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
MV
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|585034.4.peg.4239
Escherichia coli IAI1 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MAV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|585034.5.peg.4234
Escherichia coli IAI1 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MAV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|573235.3.peg.5414
Escherichia coli O26:H11 str. 11368 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MAV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|409438.11.peg.4612
Escherichia coli SE11 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MAV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|670888.3.peg.4603
Escherichia coli 1827-70 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|481805.3.peg.4185
Escherichia coli ATCC 8739 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|481805.6.peg.4172
Escherichia coli ATCC 8739 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|656408.3.peg.4630
Escherichia coli H591 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
N
M
GS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|670897.3.peg.1448
Escherichia coli 2362-75 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|362663.8.peg.4409
Escherichia coli 536 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|362663.9.peg.4425
Escherichia coli 536 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|525281.3.peg.1737
Escherichia coli 83972 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|655817.3.peg.4882
Escherichia coli ABU 83972 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|405955.13.peg.4635
Escherichia coli APEC O1 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|405955.9.peg.3917
Escherichia coli APEC O1 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|199310.1.peg.5030
Escherichia coli CFT073 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|199310.4.peg.4824
Escherichia coli CFT073 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|216593.1.peg.3872
Escherichia coli E2348/69 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|585397.7.peg.4852
Escherichia coli ED1a (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|585397.9.peg.4852
Escherichia coli ED1a (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|340197.3.peg.3481
Escherichia coli F11 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|340197.5.peg.3649
Escherichia coli F11 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|656393.3.peg.248
Escherichia coli H299 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|714962.3.peg.4673
Escherichia coli IHE3034 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|656417.3.peg.5229
Escherichia coli M605 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|749546.3.peg.1597
Escherichia coli MS 185-1 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|749550.3.peg.4453
Escherichia coli MS 200-1 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|749528.3.peg.3723
Escherichia coli MS 45-1 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|574521.7.peg.4559
Escherichia coli O127:H6 str. E2348/69 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|585035.6.peg.4533
Escherichia coli S88 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|431946.3.peg.4182
Escherichia coli SE15 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|656440.3.peg.4706
Escherichia coli TA206 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|869729.3.peg.4486
Escherichia coli UM146 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|364106.7.peg.4607
Escherichia coli UTI89 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|364106.8.peg.4606
Escherichia coli UTI89 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|562.376.peg.1806
Escherichia coli WV_060327 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|749527.3.peg.5051
Escherichia coli MS 21-1 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
M
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|1040638.4.peg.1179
Escherichia coli O104:H4 str. LB226692 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
V
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|6666666.5357.peg.4163
Escherichia coli TY-2482 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
V
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|585055.6.peg.4647
Escherichia coli 55989 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
V
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|585055.8.peg.4652
Escherichia coli 55989 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
SW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
V
GV
V
LA
W
L
ASPESRGNST
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAD
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
fig|439855.10.peg.4709
Escherichia coli SMS-3-5 (1-476/485)
M
KTPS
QPRAIY
Y
IV
A
IQIWEYFSFYGMRALLILYLT
H
QLG
F
D
D
NH
A
IS
LFSAY
A
SLVYVT
PI
LGGWLAD
R
L
LGNR
TA
V
I
A
GALLM
TL
GH
V
V
L
G
I
D
TNSTFS
LYL
A
LA
I
I
I
CGYGLFKSN
I
SCLLG
E
LY
DEN
D
H
RRDGGFSL
L
YAA
G
NIGS
IA
A
P
IA
C
G
LA
A
QW
YGW
H
V
G
F
A
L
AGG
GM
F
I
G
L
L
I
F
LS
G
H
RHF
QS
TR
SMD
K
KA
L
TSVK
F
A
L
PV
W
TW
L
V
VM
L
CLA
P
V
F
F
T
L
LL
E
-
-
--
N
D
WS
GYL
L
A
I
VCLIAAQ
I
IA
R
MMI
K
F-
-
PEH
R
RA
L
WQ
IV
L
LMF
VGT
LFW
V
LA
Q
QGGS
T
ISLFIDRFV
N
R
QA
F
N
IE
V
P
T
AL
FQS
V
NA
I
AVML
A
GV
V
LA
W
L
ASPESRGNSA
L
R
V
W
L
KFA
F
GL
L
LM
A
C
GF
ML
-
L
AFD
A
RH
A
AAG
G
QA
S
MGV
M
I
SG
L
AL
MG
F
AELFID
P
VA
I
AQIT
R
L
KM---S
GVL
T
G
I
YML
A
T
G
A
V
AN
W
LAGVVA
---
---
Q
Q
T
T
E
SQI
--
SG
---
M
A
I
A
A
Y
QR
F
F
S
Q
M
G
EW
TL
AC
V
A
II
V
V
LAFA
T
R
FLFS
TP
Consen1
Primary consensus
MNTttpm
QPraiy
iv
iqiWEyFsfYGmrallilylt
QLg
sd
a
lFsay
sLVYvt
lGGwlaD
vLGnr
vmlGAllmaiGh
v
g
s
lyl
la
I
cGyGLFKsN
scLLg
lY
DpRrDGgFsl
Yaa
NiGS
a
ia
g
a
ygw
v
f
L
Gm
i
lv
f
g
rhf
tr
K
l
F
l
w
Ll
l
pa
i
v
w
-
--
ews
L
v
i
k
k
-
R
l
iv
Lmf
lFw
la
QggssislfidrfV
r
fg
v
t
fQslNafavml
gv
LA
i
l
mw
KFa
Gl
lms
gF
-
l
a
a
G
S
mv
l
mg
aELfId
valaqit
l
Gvl
G
ymL
t
A
An
laGvvA
---
dq
td
--
sg
---
si
vY
vF
qig
tl
v
lmll
l
rmiaTPESH
Consen2
Secondary consensus
svsl
kpff
vf
el
r
gy
qg
mavffv
k
s
t
gsf
a
gl
i
vg
l
tk
i
a
ivltl
y
a
d
f
mg
v
n
a
as
s
c
h
l
a
tm
ms
v
s
sl
p
q
fsy
m
y
l
a
il
y
-
---
cq
g
p
v
i
vv
f
el
hn
dva
i
v
r
a
n
m
af
tl
fy
mpttlnfyainn
h
ln
i
p
y
a
piwi
i
sp
v
p
t
m
mca
a
aa
m
s
i
y
qs
g
m
s
lg
smva
i
fi
wf
s
f
ig
yi
avpqn
s
da
--
ain
l
a
f
kmt
aa
a
v
t
flfs
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character