┌─ Escherichia coli (85-212/216) 101-1   
                                     ┌┴─ Escherichia coli (85-209/213) 53638 (23) [3] 
                                    ┌┴──┬─ Escherichia coli (85-212/216) H299 (1)  
                               ┌────┤   └─ Escherichia coli (85-212/216) MS 182-1   
                               │    └┬─ Escherichia coli (100-212/216) M605   
                               │     └┬─ Escherichia coli (85-212/216) B171 (8)  
                          ┌────┤      └┬── Escherichia coli (3-114/409) SE11   
                          │    │       └─ Escherichia coli (85-212/216) B171 (3)  
              ┌───────────┤    └─ Escherichia coli (100-208/208) B185   
              │           └─┬─ Escherichia coli (100-221/225) B171 (2)  
              │             └┬─ Escherichia coli (100-221/225) 2362-75   
 ┌────────────┤              └─ Escherichia coli (113-234/238) E22 (25)  
 │            │                                      ┌─ Escherichia coli (90-217/221) TA280   
 │            └──────────────────────────────────────┤ ┌─ Escherichia coli (94-221/225) 55989 (1)  
 │                                                   └┬┴─ Escherichia coli (94-221/225) M605   
 │                                                    └───────────┬─ Escherichia coli (93-220/224) 1044A (24)  
 │                                                                └┬─ Escherichia coli (93-220/224) O55:H7 str. CB9615   
┌┤                                                                 └┬─ Escherichia coli (93-220/224) TA271   
││                                                                  └─ Escherichia coli (112-239/243) E2348/69 (7)  
││                       ┌─ Escherichia coli H299   
││                      ┌┴─ Escherichia coli O26:H11 str. 11368 (1)  
││                     ┌┴─ fig|1040638.4.peg.210 O104:H4 str. LB226692 (50)  
││          ┌──────────┴─ Escherichia coli MS 21-1   
│└──────────┤                ┌─── Escherichia coli (13-128/128) MS 115-1   
│           └────────────────┤┌───── Escherichia coli (17-133/133) NC101   
│                            └┤ ┌─ Escherichia coli (17-133/133) O157:H7 (78)  
│                             │┌┴─ Escherichia coli (17-133/133) O157:H7 str. EC4196   
│                             └┤┌─ Escherichia coli (17-133/133) B7A (3)  
│                              └┤ ┌── Escherichia coli (17-133/133) 042   
┤                               └┬┴─ Escherichia coli (17-133/133) S88   
│                                └┬─ Escherichia coli (17-133/133) O157:H7 EDL933   
│                                 └┬─ Escherichia coli (17-133/133) APEC O1 (127)  
│                                  └┬─ Escherichia coli (17-133/133) B7A (6)  
│                                   └┬─ Escherichia coli (17-119/152) O157:H7 EDL933   
│                                    └─ Escherichia coli (17-133/133) 536 (1)  
│                                           ┌─ fig|6666666.5357.peg.3445 TY-2482 (18-139/144) strain (12)  
│                                          ┌┴── Escherichia coli (19-125/125) B088   
│                          ┌───────────────┴─ Escherichia coli (18-139/144) TA280   
│                     ┌────┴─────────────────────────┬─ Escherichia coli (1-130/136) TA271   
│                     │                              └─ Escherichia coli (1-130/136) MS 182-1   
│                     │           ┌─ Escherichia coli (17-136/141) O157:H7 (1)  
│                     │          ┌┴─ Escherichia coli (17-136/141) O157:H7 EDL933 (1)  
└─────────────────────┤         ┌┴─┬─ Escherichia coli (17-136/141) 536   
                      │    ┌────┤  └─── Escherichia coli (8-140/145) F11   
                      │    │    └┬─ Escherichia coli (17-127/131) MS 198-1   
                      │   ┌┤     └─ Escherichia coli (17-136/141) ABU 83972   
                      │   │└┬─ Escherichia coli (7-136/141) 1044A (6)  
                      └───┤ └─ Escherichia coli (8-136/141) O157:H7 EDL933   
                          │ ┌─ Escherichia coli (7-136/141) HS   
                          └─┤┌─ fig|1040638.4.peg.682 O104:H4 (7-136/141) str. LB226692 (10)  
                            ││  ┌─ Escherichia coli (7-113/118) H591   
                            └┤ ┌┴─ Escherichia coli (11-136/141) B171 (3)  
                             │┌┴┬─ Escherichia coli (7-136/141) H299   
                             └┤ └─ Escherichia coli (9-139/144) E110019   
                              │┌─ Escherichia coli (7-136/141) ED1a (1)  
                              └┤ ┌─ Escherichia coli (7-136/141) S88   
                               └┬┴─ fig|1040638.4.peg.979 O104:H4 (11-136/141) str. LB226692   
                                └┬─ Escherichia coli (7-136/141) EC4100B   
                                 └─ Escherichia coli (7-136/141) E110019 (1)  
  
ISSfl3 orfA (15)
IS, phage, Tn; Transposon-related functions (13)
hypothetical protein (12)
unknown in ISEc8 (5)
Insertion Sequence Associated (4)
COG2963: Transposase and inactivated derivatives (1)
unknown in putative ISEc8 (1)
putative transposase (1)
Unknown in ISEc8 (1)
unknown protein encoded by ISEc8 in prophage CP-933X (1)
Unknown protein encoded by ISEc8 (1)
Others (4)