fig|6666666.5357.peg.3438
Escherichia coli TY-2482 (438-1048/1048)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
S
M
AG
AA
A
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPA
E
T
SNPLN
R
V
L------
-
---IKA
Y
HPL
L
L
R
V
L
HWPKTT
L
L
V
A
ALS
I
FTVIW
P
LSQ
V
G
GE
FLP
KI
N
E
G
DLLYMP
S
T
L
P
G
V
S
PAEAAALLQ
T
TDKL
I
K--SVPE
V
A
SVF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
ED
Q
W
R
PG--MTID
K
II
E
EL
DRTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
SD
I
DATAQ
S
I
EAV
A
KTV
P
G-
V
VS
A
LA
E
R
LE
GGRYID
V
DI
NR
E
KA
S
RY
G
MTV
G
D
V
QLF
I
S
S
A
I
G
GAT
V
GETVEGVARYP
IN
IRYPQD
YR
NS
P
Q
A
----------
L
KQMP
I
L
T
PM
K
QQ
ITL
G
DV
A
DIKVVS
G
P
TM
L
KTE
N
AR
P
ASW
I
YID
A
R
G
RD
M
V
S
V
V
NDIKTAISQKVK
L
R
P
G
TSVS
F
S
G
--
---
Q
FE
L
LE
H
ANKKLKL
M
VPM
T
V
M
I
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FH
M
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
H
P
E
L
SRKE
TF
TP
EGLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
L
I
WL
R
RH
K
KSVS
fig|585055.6.peg.3944
Escherichia coli 55989 (438-1048/1048)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
S
M
AG
AA
A
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPA
E
T
SNPLN
R
V
L------
-
---IKA
Y
HPL
L
L
R
V
L
HWPKTT
L
L
V
A
ALS
I
FTVIW
P
LSQ
V
G
GE
FLP
KI
N
E
G
DLLYMP
S
T
L
P
G
V
S
PAEAAALLQ
T
TDKL
I
K--SVPE
V
A
SVF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
ED
Q
W
R
PG--MTID
K
II
E
EL
DRTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
SD
I
DATAQ
S
I
EAV
A
KTV
P
G-
V
VS
A
LA
E
R
LE
GGRYID
V
DI
NR
E
KA
S
RY
G
MTV
G
D
V
QLF
I
S
S
A
I
G
GAT
V
GETVEGVARYP
IN
IRYPQD
YR
NS
P
Q
A
----------
L
KQMP
I
L
T
PM
K
QQ
ITL
G
DV
A
DIKVVS
G
P
TM
L
KTE
N
AR
P
ASW
I
YID
A
R
G
RD
M
V
S
V
V
NDIKTAISQKVK
L
R
P
G
TSVS
F
S
G
--
---
Q
FE
L
LE
H
ANKKLKL
M
VPM
T
V
M
I
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FH
M
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
H
P
E
L
SRKE
TF
TP
EGLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
L
I
WL
R
RH
K
KSVS
fig|585055.8.peg.3946
Escherichia coli 55989 (438-1048/1048)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
S
M
AG
AA
A
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPA
E
T
SNPLN
R
V
L------
-
---IKA
Y
HPL
L
L
R
V
L
HWPKTT
L
L
V
A
ALS
I
FTVIW
P
LSQ
V
G
GE
FLP
KI
N
E
G
DLLYMP
S
T
L
P
G
V
S
PAEAAALLQ
T
TDKL
I
K--SVPE
V
A
SVF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
ED
Q
W
R
PG--MTID
K
II
E
EL
DRTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
SD
I
DATAQ
S
I
EAV
A
KTV
P
G-
V
VS
A
LA
E
R
LE
GGRYID
V
DI
NR
E
KA
S
RY
G
MTV
G
D
V
QLF
I
S
S
A
I
G
GAT
V
GETVEGVARYP
IN
IRYPQD
YR
NS
P
Q
A
----------
L
KQMP
I
L
T
PM
K
QQ
ITL
G
DV
A
DIKVVS
G
P
TM
L
KTE
N
AR
P
ASW
I
YID
A
R
G
RD
M
V
S
V
V
NDIKTAISQKVK
L
R
P
G
TSVS
F
S
G
--
---
Q
FE
L
LE
H
ANKKLKL
M
VPM
T
V
M
I
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FH
M
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
H
P
E
L
SRKE
TF
TP
EGLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
L
I
WL
R
RH
K
KSVS
fig|405955.13.peg.5316
Escherichia coli APEC O1 (438-1048/1048)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
S
M
AG
AA
A
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPA
E
T
SNPLN
R
V
L------
-
---IKA
Y
HPL
L
L
R
V
L
HWPKTT
L
L
V
A
ALS
I
FTVIW
P
LSQ
V
G
GE
FLP
KI
N
E
G
DLLYMP
S
T
L
P
G
V
S
PAEAAALLQ
T
TDKL
I
K--SVPE
V
A
SVF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
ED
Q
W
R
PG--MTID
K
II
E
EL
DRTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
SD
I
DATAQ
S
I
EAV
A
KTV
P
G-
V
VS
A
LA
E
R
LE
GGRYID
V
DI
NR
E
KA
S
RY
G
MTV
G
D
V
QLF
I
S
S
A
I
G
GAT
V
GETVEGVARYP
IN
IRYPQD
YR
NS
P
Q
A
----------
L
KQMP
I
L
T
PM
K
QQ
ITL
G
DV
A
DIKVVS
G
P
TM
L
KTE
N
AR
P
ASW
I
YID
A
R
G
RD
M
V
S
V
V
NDIKTAISQKVK
L
R
P
G
TSVS
F
S
G
--
---
Q
FE
L
LE
H
ANKKLKL
M
VPM
T
V
M
I
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FH
M
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
H
P
E
L
SRKE
TF
TP
EGLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
L
I
WL
R
RH
K
KSVS
fig|405955.9.peg.4433
Escherichia coli APEC O1 (438-1048/1048)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
S
M
AG
AA
A
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPA
E
T
SNPLN
R
V
L------
-
---IKA
Y
HPL
L
L
R
V
L
HWPKTT
L
L
V
A
ALS
I
FTVIW
P
LSQ
V
G
GE
FLP
KI
N
E
G
DLLYMP
S
T
L
P
G
V
S
PAEAAALLQ
T
TDKL
I
K--SVPE
V
A
SVF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
ED
Q
W
R
PG--MTID
K
II
E
EL
DRTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
SD
I
DATAQ
S
I
EAV
A
KTV
P
G-
V
VS
A
LA
E
R
LE
GGRYID
V
DI
NR
E
KA
S
RY
G
MTV
G
D
V
QLF
I
S
S
A
I
G
GAT
V
GETVEGVARYP
IN
IRYPQD
YR
NS
P
Q
A
----------
L
KQMP
I
L
T
PM
K
QQ
ITL
G
DV
A
DIKVVS
G
P
TM
L
KTE
N
AR
P
ASW
I
YID
A
R
G
RD
M
V
S
V
V
NDIKTAISQKVK
L
R
P
G
TSVS
F
S
G
--
---
Q
FE
L
LE
H
ANKKLKL
M
VPM
T
V
M
I
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FH
M
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
H
P
E
L
SRKE
TF
TP
EGLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
L
I
WL
R
RH
K
KSVS
fig|481805.3.peg.3679
Escherichia coli ATCC 8739 (438-1048/1048)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
S
M
AG
AA
A
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPA
E
T
SNPLN
R
V
L------
-
---IKA
Y
HPL
L
L
R
V
L
HWPKTT
L
L
V
A
ALS
I
FTVIW
P
LSQ
V
G
GE
FLP
KI
N
E
G
DLLYMP
S
T
L
P
G
V
S
PAEAAALLQ
T
TDKL
I
K--SVPE
V
A
SVF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
ED
Q
W
R
PG--MTID
K
II
E
EL
DRTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
SD
I
DVTAQ
S
I
EAV
A
KTV
P
G-
V
VS
A
LA
E
R
LE
GGRYID
V
DI
NR
E
KA
S
RY
G
MTV
G
D
V
QLF
V
S
S
A
I
G
GAM
V
GETVEGVARYP
IN
IRYPQD
YR
NS
P
Q
A
----------
L
REMP
I
L
T
PM
K
QQ
ITL
G
DV
A
DIKVVS
G
P
TM
L
KTE
N
AR
P
ASW
I
YVD
A
R
G
RD
M
V
S
V
V
NDIKTAISEKVK
L
R
P
G
TSVA
F
S
G
--
---
Q
FE
L
LE
H
ANKKLKL
M
VPM
T
V
M
I
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FH
M
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
H
P
E
L
SRKE
TF
TP
EGLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
L
I
WL
R
K
H
K
KSVS
fig|481805.6.peg.3657
Escherichia coli ATCC 8739 (438-1048/1048)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
S
M
AG
AA
A
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPA
E
T
SNPLN
R
V
L------
-
---IKA
Y
HPL
L
L
R
V
L
HWPKTT
L
L
V
A
ALS
I
FTVIW
P
LSQ
V
G
GE
FLP
KI
N
E
G
DLLYMP
S
T
L
P
G
V
S
PAEAAALLQ
T
TDKL
I
K--SVPE
V
A
SVF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
ED
Q
W
R
PG--MTID
K
II
E
EL
DRTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
SD
I
DVTAQ
S
I
EAV
A
KTV
P
G-
V
VS
A
LA
E
R
LE
GGRYID
V
DI
NR
E
KA
S
RY
G
MTV
G
D
V
QLF
V
S
S
A
I
G
GAM
V
GETVEGVARYP
IN
IRYPQD
YR
NS
P
Q
A
----------
L
REMP
I
L
T
PM
K
QQ
ITL
G
DV
A
DIKVVS
G
P
TM
L
KTE
N
AR
P
ASW
I
YVD
A
R
G
RD
M
V
S
V
V
NDIKTAISEKVK
L
R
P
G
TSVA
F
S
G
--
---
Q
FE
L
LE
H
ANKKLKL
M
VPM
T
V
M
I
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FH
M
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
H
P
E
L
SRKE
TF
TP
EGLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
L
I
WL
R
K
H
K
KSVS
fig|316401.4.peg.250
Escherichia coli ETEC H10407 (438-1048/1048)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
S
M
AG
AA
A
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPA
E
T
SNPLN
R
V
L------
-
---IKA
Y
HPL
L
L
R
V
L
HWPKTT
L
L
V
A
ALS
I
FTVIW
P
LSQ
V
G
GE
FLP
KI
N
E
G
DLLYMP
S
T
L
P
G
V
S
PAEAAALLQ
T
TDKL
I
K--SVPE
V
A
SVF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
ED
Q
W
R
PG--MTID
K
II
E
EL
DRTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
SD
I
DVTAQ
S
I
EAV
A
KTV
P
G-
V
VS
A
LA
E
R
LE
GGRYID
V
DI
NR
E
KA
S
RY
G
MTV
G
D
V
QLF
V
S
S
A
I
G
GAM
V
GETVEGVARYP
IN
IRYPQD
YR
NS
P
Q
A
----------
L
REMP
I
L
T
PM
K
QQ
ITL
G
DV
A
DIKVVS
G
P
TM
L
KTE
N
AR
P
ASW
I
YVD
A
R
G
RD
M
V
S
V
V
NDIKTAISEKVK
L
R
P
G
TSVA
F
S
G
--
---
Q
FE
L
LE
H
ANKKLKL
M
VPM
T
V
M
I
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FH
M
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
H
P
E
L
SRKE
TF
TP
EGLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
L
I
WL
R
K
H
K
KSVS
fig|749537.3.peg.100
Escherichia coli MS 115-1 (438-1048/1048)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
S
M
AG
AA
A
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPA
E
T
SNPLN
R
V
L------
-
---IKA
Y
HPL
L
L
R
V
L
HWPKTT
L
L
V
A
ALS
I
FTVIW
P
LSQ
V
G
GE
FLP
KI
N
E
G
DLLYMP
S
T
L
P
G
V
S
PAEAAALLQ
T
TDKL
I
K--SVPE
V
A
SVF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
ED
Q
W
R
PG--MTID
K
II
E
EL
DRTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
SD
I
DVTAQ
S
I
EAV
A
KTV
P
G-
V
VS
A
LA
E
R
LE
GGRYID
V
DI
NR
E
KA
S
RY
G
MTV
G
D
V
QLF
V
S
S
A
I
G
GAM
V
GETVEGVARYP
IN
IRYPQD
YR
NS
P
Q
A
----------
L
REMP
I
L
T
PM
K
QQ
ITL
G
DV
A
DIKVVS
G
P
TM
L
KTE
N
AR
P
ASW
I
YVD
A
R
G
RD
M
V
S
V
V
NDIKTAISEKVK
L
R
P
G
TSVA
F
S
G
--
---
Q
FE
L
LE
H
ANKKLKL
M
VPM
T
V
M
I
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FH
M
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
H
P
E
L
SRKE
TF
TP
EGLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
L
I
WL
R
K
H
K
KSVS
fig|1040638.4.peg.2095
Escherichia coli O104:H4 str. LB226692
M
ITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
S
M
AG
AA
A
L
A
I
I
VI
P
I
L
MG
FW
I
RGKIPA
E
T
SNPLN
R
V
L------
-
---IKA
Y
HPL
L
L
R
V
L
HWPKTT
L
L
V
A
ALS
I
FTVIW
P
LSQ
V
G
GE
FLP
KI
N
E
G
DLLYMP
S
T
L
P
G
V
S
PAEAAALLQ
T
TDKL
I
K--SVPE
V
A
SVF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
ED
Q
W
R
PG--MTID
K
II
E
EL
DRTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
SD
I
DATAQ
S
I
EAV
A
KTV
P
G-
V
VS
A
LA
E
R
LE
GGRYID
V
DI
NR
E
KA
S
RY
G
MTV
G
D
V
QLF
I
S
S
A
I
G
GAT
V
GETVEGVARYP
IN
IRYPQD
YR
NS
P
Q
A
----------
L
KQMP
I
L
T
PM
K
QQ
ITL
G
DV
A
DIKVVS
G
P
TM
L
KTE
N
AR
P
ASW
I
YID
A
R
G
RD
M
V
S
V
V
NDIKTAISQKVK
L
R
P
G
TSVS
F
S
G
--
---
Q
FE
L
LE
H
ANKKLKL
M
VPM
T
V
M
I
I
F
I
L
L
YL
AFRR
VDE
A
LL
I
LM
S
L
P
F
A
L
VG
G
IW
F
LYWQ
G
FH
M
S
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
H
P
E
L
SRKE
TF
TP
EGLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
L
I
WL
R
RH
K
KSVS
fig|656379.3.peg.1353
Escherichia coli FVEC1302 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
I
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRA
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|656380.3.peg.1181
Escherichia coli FVEC1412 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
I
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRA
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|749549.3.peg.4797
Escherichia coli MS 198-1 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
I
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRA
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|585056.7.peg.862
Escherichia coli UMN026 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
I
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRA
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|749531.3.peg.3440
Escherichia coli MS 69-1 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRA
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
NS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVT
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEV
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|656437.3.peg.647
Escherichia coli TA143 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
I
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRA
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
M
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|656419.3.peg.850
Escherichia coli M718 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVIW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|550677.3.peg.993
Escherichia coli B354 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|340184.3.peg.4467
Escherichia coli B7A (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|340184.6.peg.4678
Escherichia coli B7A (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|331111.12.peg.899
Escherichia coli E24377A (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|331111.3.peg.3124
Escherichia coli E24377A (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|562.375.peg.1588
Escherichia coli EC4100B (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|595495.4.peg.2045
Escherichia coli KO11 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|679204.3.peg.5117
Escherichia coli MS 145-7 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|749532.3.peg.3646
Escherichia coli MS 78-1 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|409438.11.peg.764
Escherichia coli SE11 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|566546.3.peg.4930
Escherichia coli W (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|566546.4.peg.631
Escherichia coli W (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|749545.3.peg.4929
Escherichia coli MS 182-1 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|749537.3.peg.4060
Escherichia coli MS 115-1 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|585396.4.peg.625
Escherichia coli O111:H- str. 11128 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|362663.8.peg.608
Escherichia coli 536 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VSE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|362663.9.peg.609
Escherichia coli 536 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VSE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|340197.3.peg.2412
Escherichia coli F11 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VSE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|340197.5.peg.2530
Escherichia coli F11 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VSE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|749550.3.peg.4627
Escherichia coli MS 200-1 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VSE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|670897.3.peg.172
Escherichia coli 2362-75 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVFT
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|216593.1.peg.3046
Escherichia coli E2348/69 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVFT
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|574521.7.peg.511
Escherichia coli O127:H6 str. E2348/69 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVFT
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|679207.4.peg.2892
Escherichia coli MS 107-1 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|525281.3.peg.2364
Escherichia coli 83972 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|655817.3.peg.665
Escherichia coli ABU 83972 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|585397.7.peg.568
Escherichia coli ED1a (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|585397.9.peg.570
Escherichia coli ED1a (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|656408.3.peg.504
Escherichia coli H591 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
T
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|585057.4.peg.586
Escherichia coli IAI39 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|585057.6.peg.584
Escherichia coli IAI39 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|656417.3.peg.694
Escherichia coli M605 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|679206.4.peg.4715
Escherichia coli MS 119-7 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
T
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|749546.3.peg.3398
Escherichia coli MS 185-1 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|749528.3.peg.4064
Escherichia coli MS 45-1 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|753642.3.peg.1083
Escherichia coli NC101 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|685038.3.peg.517
Escherichia coli O83:H1 str. NRG 857C (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|585035.6.peg.608
Escherichia coli S88 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|431946.3.peg.521
Escherichia coli SE15 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|439855.10.peg.762
Escherichia coli SMS-3-5 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|562.376.peg.2042
Escherichia coli WV_060327 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|573235.3.peg.654
Escherichia coli O26:H11 str. 11368 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|340186.3.peg.2228
Escherichia coli E110019 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|340186.5.peg.2300
Escherichia coli E110019 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|749540.3.peg.485
Escherichia coli MS 146-1 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|656444.3.peg.1047
Escherichia coli TA280 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TNKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|216592.1.peg.326
Escherichia coli 042 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|216592.3.peg.634
Escherichia coli 042 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|656414.3.peg.748
Escherichia coli H736 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|1040638.4.peg.5263
Escherichia coli O104:H4 str. LB226692 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
T
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|6666666.5357.peg.2328
Escherichia coli TY-2482 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
T
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|358709.5.peg.1979
Escherichia coli 101-1 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|670888.3.peg.1135
Escherichia coli 1827-70 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|344610.3.peg.1558
Escherichia coli 53638 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|344610.7.peg.1121
Escherichia coli 53638 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|481805.3.peg.3294
Escherichia coli ATCC 8739 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|481805.6.peg.3280
Escherichia coli ATCC 8739 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|413997.3.peg.563
Escherichia coli B str. REL606 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|550672.3.peg.142
Escherichia coli B088 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|511693.5.peg.558
Escherichia coli BL21 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|469008.4.peg.3196
Escherichia coli BL21(DE3) (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|595496.3.peg.496
Escherichia coli BW2952 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|536056.3.peg.3227
Escherichia coli DH1 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|340185.3.peg.1764
Escherichia coli E22 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|340185.4.peg.1859
Escherichia coli E22 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|331112.3.peg.579
Escherichia coli HS (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|331112.6.peg.606
Escherichia coli HS (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|585034.4.peg.550
Escherichia coli IAI1 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|585034.5.peg.549
Escherichia coli IAI1 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|83333.1.peg.573
Escherichia coli K12 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|749538.3.peg.2539
Escherichia coli MS 116-1 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|679205.4.peg.578
Escherichia coli MS 124-1 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|749544.3.peg.295
Escherichia coli MS 175-1 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|749548.3.peg.3348
Escherichia coli MS 196-1 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|749533.3.peg.5382
Escherichia coli MS 84-1 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|585395.4.peg.609
Escherichia coli O103:H2 str. 12009 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|316407.3.peg.556
Escherichia coli W3110 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|316385.5.peg.527
Escherichia coli str. K-12 substr. DH10B (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|316385.5.peg.638
Escherichia coli str. K-12 substr. DH10B (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|316385.7.peg.535
Escherichia coli str. K-12 substr. DH10B (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|316385.7.peg.646
Escherichia coli str. K-12 substr. DH10B (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|511145.12.peg.599
Escherichia coli str. K-12 substr. MG1655 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|511145.6.peg.590
Escherichia coli str. K-12 substr. MG1655 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|749527.3.peg.4942
Escherichia coli MS 21-1 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
Q
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
K
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|585055.6.peg.576
Escherichia coli 55989 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
T
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|585055.8.peg.577
Escherichia coli 55989 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
T
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|656440.3.peg.427
Escherichia coli TA206 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTALW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|656393.3.peg.1249
Escherichia coli H299 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
T
TD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|316401.4.peg.692
Escherichia coli ETEC H10407 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|199310.1.peg.636
Escherichia coli CFT073 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
XNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|199310.4.peg.626
Escherichia coli CFT073 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
XNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|714962.3.peg.600
Escherichia coli IHE3034 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
AMGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|869729.3.peg.3132
Escherichia coli UM146 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
AMGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|364106.7.peg.680
Escherichia coli UTI89 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
AMGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|364106.8.peg.678
Escherichia coli UTI89 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
AMGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|405955.13.peg.550
Escherichia coli APEC O1 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
G
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|405955.9.peg.452
Escherichia coli APEC O1 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DTMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
G
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|344601.3.peg.2299
Escherichia coli B171 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
Q
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|344601.5.peg.2400
Escherichia coli B171 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
Q
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|562.371.peg.2826
Escherichia coli 1044A (436-1042/1045)
VIT
N
ASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
H
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|562.373.peg.3167
Escherichia coli 1125A (436-1042/1045)
VIT
N
ASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
H
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|562.372.peg.1557
Escherichia coli 1212A (436-1042/1045)
VIT
N
ASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
H
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|562.374.peg.5419
Escherichia coli 536A (436-1042/1045)
VIT
N
ASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
H
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|83334.1.peg.686
Escherichia coli O157:H7 (436-1042/1045)
VIT
N
ASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
H
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|155864.1.peg.608
Escherichia coli O157:H7 EDL933 (436-1042/1045)
VIT
N
ASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
H
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|155864.8.peg.623
Escherichia coli O157:H7 EDL933 (436-1042/1045)
VIT
N
ASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
H
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|444454.5.peg.5098
Escherichia coli O157:H7 str. EC4024 (436-1042/1045)
VIT
N
ASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
H
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|444449.5.peg.5434
Escherichia coli O157:H7 str. EC4042 (436-1042/1045)
VIT
N
ASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
H
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|444448.5.peg.3308
Escherichia coli O157:H7 str. EC4045 (436-1042/1045)
VIT
N
ASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
H
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|444453.5.peg.650
Escherichia coli O157:H7 str. EC4076 (436-1042/1045)
VIT
N
ASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
H
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|444452.5.peg.878
Escherichia coli O157:H7 str. EC4113 (436-1042/1045)
VIT
N
ASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
H
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|444450.8.peg.768
Escherichia coli O157:H7 str. EC4115 (436-1042/1045)
VIT
N
ASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
H
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|444451.5.peg.2270
Escherichia coli O157:H7 str. EC4196 (436-1042/1045)
VIT
N
ASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
H
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|444447.5.peg.3483
Escherichia coli O157:H7 str. EC4206 (436-1042/1045)
VIT
N
ASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
H
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|478004.5.peg.1476
Escherichia coli O157:H7 str. EC4401 (436-1042/1045)
VIT
N
ASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
H
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|478005.5.peg.3986
Escherichia coli O157:H7 str. EC4486 (436-1042/1045)
VIT
N
ASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
H
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|478006.5.peg.835
Escherichia coli O157:H7 str. EC4501 (436-1042/1045)
VIT
N
ASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
H
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|478007.5.peg.967
Escherichia coli O157:H7 str. EC508 (436-1042/1045)
VIT
N
ASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
H
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|478008.5.peg.1710
Escherichia coli O157:H7 str. EC869 (436-1042/1045)
VIT
N
ASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
H
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|637388.3.peg.1105
Escherichia coli O157:H7 str. FRIK2000 (436-1042/1045)
VIT
N
ASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
H
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|570506.3.peg.3642
Escherichia coli O157:H7 str. FRIK966 (436-1042/1045)
VIT
N
ASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
H
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|386585.9.peg.721
Escherichia coli O157:H7 str. Sakai (436-1042/1045)
VIT
N
ASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
H
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|544404.4.peg.633
Escherichia coli O157:H7 str. TW14359 (436-1042/1045)
VIT
N
ASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
H
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|502346.5.peg.588
Escherichia coli O157:H7 str. TW14588 (436-1042/1045)
VIT
N
ASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
H
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|749547.3.peg.3540
Escherichia coli MS 187-1 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
SG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DIKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
V
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|550676.3.peg.38
Escherichia coli B185 (438-1044/1047)
VITDASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HRPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QD
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
RY
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
V
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|701177.3.peg.733
Escherichia coli O55:H7 str. CB9615 (438-1044/1047)
VIT
N
ASVEVGPALFISL
LI
I
T
LS
FIP
I
F
T
L
E
G
QE
G
RLFG
P
LAF
T
KTY
AM
AG
AA
L
L
A
I
V
VI
P
I
L
MG
YW
I
RGKIPP
E
S
SNPLN
R
F
L------
-
---IRV
Y
HPL
L
L
K
V
L
HWPKTT
L
L
V
A
ALS
V
LTVLW
P
LNK
V
G
GE
FLP
QI
N
E
G
DLLYMP
S
T
L
P
G
I
S
AAEAASMLQ
K
TDKL
I
M--SVPE
V
A
R
VF
GKT
G
KAET
ATD
SAP
LE
MVETT
I
Q
LKP
QE
Q
W
R
PG--MTMD
K
II
E
EL
DNTV-
RL
P
G
LANLWV
P
PIRNR
I
DM
L
S
T
GIKSPIG
I
K
-
VS
G
TV
L
AD
I
DAMAE
Q
I
EEV
A
RTV
P
G-
V
AS
A
LA
E
R
LE
GGRYIN
VE
I
NR
E
KA
A
G
Y
G
MTV
A
D
V
QLF
V
T
S
A
V
G
GAM
V
GETVEGIARYP
IN
LRYPQS
W
R
DS
P
Q
A
----------
L
RQLP
I
L
T
PM
K
QQ
ITLA
DV
A
DVKVST
G
P
SM
L
KTE
N
AR
P
TSW
I
YID
A
R
D
RD
M
V
S
V
V
HDLQKAIAEKVQ
L
K
P
G
TSVA
F
S
G
--
---
Q
FE
L
LER
ANHKLKL
M
VPM
T
L
M
I
I
F
V
L
L
YL
AFRR
VGE
A
LL
I
I
S
S
VP
F
A
L
VG
G
IWL
LWWM
G
FH
LS
V
ATGT
G
F
I
AL
A
G
V
A
A
EFGV
V
M
L
M
YL
RHAIEA
E
PSLNNPQTFSE
QKLD
EA
L
Y
H
G
AVL
R
V
RP
KA
MT
V
AV
I
I
A
G
L
LP
I
LW
G
TGAGS
E
VMSR
I
A
A
PM
I
GGMI
T
A
P
L
L
S
L
F
II
P
AA
Y
K
LMWLHRHR
fig|550677.3.peg.1624
Escherichia coli B354 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVL
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|749528.3.peg.1606
Escherichia coli MS 45-1 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
I
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
G
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|340186.3.peg.2458
Escherichia coli E110019 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|340186.5.peg.2537
Escherichia coli E110019 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|358709.5.peg.523
Escherichia coli 101-1 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
E
L
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|413997.3.peg.2072
Escherichia coli B str. REL606 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
E
L
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|511693.5.peg.2103
Escherichia coli BL21 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
E
L
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|469008.4.peg.1629
Escherichia coli BL21(DE3) (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
E
L
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|749547.3.peg.3117
Escherichia coli MS 187-1 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
E
L
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|749548.3.peg.2930
Escherichia coli MS 196-1 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
E
L
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|749549.3.peg.1282
Escherichia coli MS 198-1 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
E
L
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|316385.5.peg.2190
Escherichia coli str. K-12 substr. DH10B (423-1004/1023)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|340197.3.peg.135
Escherichia coli F11 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
P
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|340197.5.peg.139
Escherichia coli F11 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
P
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|749550.3.peg.1588
Escherichia coli MS 200-1 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
P
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|753642.3.peg.3016
Escherichia coli NC101 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
ISII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|405955.13.peg.2260
Escherichia coli APEC O1 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|405955.9.peg.1843
Escherichia coli APEC O1 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|199310.1.peg.2532
Escherichia coli CFT073 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|199310.4.peg.2446
Escherichia coli CFT073 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|714962.3.peg.2348
Escherichia coli IHE3034 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|749546.3.peg.2833
Escherichia coli MS 185-1 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|749527.3.peg.1512
Escherichia coli MS 21-1 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|749531.3.peg.2069
Escherichia coli MS 69-1 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|585035.6.peg.2154
Escherichia coli S88 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|439855.10.peg.1143
Escherichia coli SMS-3-5 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|656440.3.peg.2059
Escherichia coli TA206 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|869729.3.peg.1363
Escherichia coli UM146 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|364106.7.peg.2375
Escherichia coli UTI89 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|364106.8.peg.2378
Escherichia coli UTI89 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|562.376.peg.3981
Escherichia coli WV_060327 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|362663.8.peg.2126
Escherichia coli 536 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|362663.9.peg.2131
Escherichia coli 536 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|585397.7.peg.2437
Escherichia coli ED1a (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEPRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|585397.9.peg.2435
Escherichia coli ED1a (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEPRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|656417.3.peg.2742
Escherichia coli M605 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|749538.3.peg.1296
Escherichia coli MS 116-1 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|679205.4.peg.2972
Escherichia coli MS 124-1 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|749533.3.peg.436
Escherichia coli MS 84-1 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|431946.3.peg.2048
Escherichia coli SE15 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|670888.3.peg.4212
Escherichia coli 1827-70 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|344610.3.peg.2093
Escherichia coli 53638 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|344610.7.peg.4398
Escherichia coli 53638 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|481805.3.peg.1678
Escherichia coli ATCC 8739 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|481805.6.peg.1673
Escherichia coli ATCC 8739 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|595496.3.peg.2043
Escherichia coli BW2952 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|536056.3.peg.1670
Escherichia coli DH1 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|656393.3.peg.3099
Escherichia coli H299 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|83333.1.peg.2051
Escherichia coli K12 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|595495.4.peg.2945
Escherichia coli KO11 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|656419.3.peg.2830
Escherichia coli M718 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|566546.3.peg.2499
Escherichia coli W (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|566546.4.peg.2219
Escherichia coli W (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|316407.3.peg.2011
Escherichia coli W3110 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|316385.7.peg.2240
Escherichia coli str. K-12 substr. DH10B (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|511145.12.peg.2152
Escherichia coli str. K-12 substr. MG1655 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|511145.6.peg.2137
Escherichia coli str. K-12 substr. MG1655 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|749540.3.peg.199
Escherichia coli MS 146-1 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LTAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|478005.5.peg.3683
Escherichia coli O157:H7 str. EC4486 (423-1004/1023)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
I
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|331112.3.peg.2073
Escherichia coli HS (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|331112.6.peg.2168
Escherichia coli HS (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|340185.3.peg.1199
Escherichia coli E22 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTE
I
TPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|340185.4.peg.1265
Escherichia coli E22 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTE
I
TPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|585395.4.peg.2670
Escherichia coli O103:H2 str. 12009 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTE
I
TPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|316401.4.peg.2539
Escherichia coli ETEC H10407 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
S
P
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|562.371.peg.4280
Escherichia coli 1044A (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
I
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|562.373.peg.4607
Escherichia coli 1125A (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
I
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|562.372.peg.5780
Escherichia coli 1212A (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
I
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|562.374.peg.1790
Escherichia coli 536A (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
I
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|83334.1.peg.2887
Escherichia coli O157:H7 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
I
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|155864.1.peg.2891
Escherichia coli O157:H7 EDL933 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
I
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|155864.8.peg.2775
Escherichia coli O157:H7 EDL933 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
I
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|444454.5.peg.1747
Escherichia coli O157:H7 str. EC4024 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
I
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|444449.5.peg.1223
Escherichia coli O157:H7 str. EC4042 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
I
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|444448.5.peg.5497
Escherichia coli O157:H7 str. EC4045 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
I
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|444453.5.peg.3716
Escherichia coli O157:H7 str. EC4076 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
I
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|444452.5.peg.3369
Escherichia coli O157:H7 str. EC4113 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
I
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|444450.8.peg.3017
Escherichia coli O157:H7 str. EC4115 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
I
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|444451.5.peg.3058
Escherichia coli O157:H7 str. EC4196 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
I
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|444447.5.peg.118
Escherichia coli O157:H7 str. EC4206 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
I
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|478004.5.peg.4589
Escherichia coli O157:H7 str. EC4401 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
I
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|478006.5.peg.2302
Escherichia coli O157:H7 str. EC4501 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
I
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|478007.5.peg.1817
Escherichia coli O157:H7 str. EC508 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
I
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|478008.5.peg.3901
Escherichia coli O157:H7 str. EC869 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
I
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|637388.3.peg.2194
Escherichia coli O157:H7 str. FRIK2000 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
I
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|570506.3.peg.3472
Escherichia coli O157:H7 str. FRIK966 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
I
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|386585.9.peg.3015
Escherichia coli O157:H7 str. Sakai (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
I
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|544404.4.peg.2879
Escherichia coli O157:H7 str. TW14359 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
I
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|502346.5.peg.4502
Escherichia coli O157:H7 str. TW14588 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
I
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|344601.3.peg.3240
Escherichia coli B171 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTE
I
TPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
S
P
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|344601.5.peg.3386
Escherichia coli B171 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTE
I
TPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
S
P
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|216592.1.peg.2869
Escherichia coli 042 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TT
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
QGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|216592.3.peg.2415
Escherichia coli 042 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TT
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
QGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|562.375.peg.2295
Escherichia coli EC4100B (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
E
L
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|656414.3.peg.2434
Escherichia coli H736 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
E
L
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|585034.4.peg.2126
Escherichia coli IAI1 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
E
L
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|585034.5.peg.2121
Escherichia coli IAI1 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
E
L
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|679207.4.peg.3868
Escherichia coli MS 107-1 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
E
L
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|679206.4.peg.1593
Escherichia coli MS 119-7 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
E
L
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|679204.3.peg.105
Escherichia coli MS 145-7 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
E
L
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|749544.3.peg.957
Escherichia coli MS 175-1 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
E
L
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|656443.3.peg.2773
Escherichia coli TA271 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
E
L
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|1040638.4.peg.3157
Escherichia coli O104:H4 str. LB226692 (55-636/655)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GQG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LE
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|670897.3.peg.2991
Escherichia coli 2362-75 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
ERIIAA
Y
GQG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|525281.3.peg.3878
Escherichia coli 83972 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|655817.3.peg.2518
Escherichia coli ABU 83972 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|550672.3.peg.1794
Escherichia coli B088 (423-1004/1023)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|216593.1.peg.2687
Escherichia coli E2348/69 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
ERIIAA
Y
GQG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|574521.7.peg.2266
Escherichia coli O127:H6 str. E2348/69 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
ERIIAA
Y
GQG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|331111.12.peg.2647
Escherichia coli E24377A (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|331111.3.peg.109
Escherichia coli E24377A (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|656444.3.peg.3048
Escherichia coli TA280 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|340184.3.peg.3957
Escherichia coli B7A (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTE
I
TPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|340184.6.peg.4139
Escherichia coli B7A (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTE
I
TPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|749537.3.peg.892
Escherichia coli MS 115-1 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTE
I
TPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|585396.4.peg.2889
Escherichia coli O111:H- str. 11128 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTE
I
TPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|409438.11.peg.2499
Escherichia coli SE11 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTE
I
TPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|573235.3.peg.3050
Escherichia coli O26:H11 str. 11368 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTE
I
TPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|585057.4.peg.992
Escherichia coli IAI39 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FTNMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
VEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|585057.6.peg.989
Escherichia coli IAI39 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FTNMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
VEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|685038.3.peg.2129
Escherichia coli O83:H1 str. NRG 857C (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
D
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
EA
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|585055.6.peg.2366
Escherichia coli 55989 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GQG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LE
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|585055.8.peg.2373
Escherichia coli 55989 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GQG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LE
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|749532.3.peg.4103
Escherichia coli MS 78-1 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GQG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LE
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|656379.3.peg.2607
Escherichia coli FVEC1302 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
ERIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FTNMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
INM
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|656380.3.peg.2167
Escherichia coli FVEC1412 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
ERIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FTNMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
INM
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|656437.3.peg.2336
Escherichia coli TA143 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
ERIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FTNMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
INM
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|585056.7.peg.2594
Escherichia coli UMN026 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
ERIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FTNMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
INM
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|656408.3.peg.2278
Escherichia coli H591 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GQG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LE
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|749545.3.peg.10
Escherichia coli MS 182-1 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GQG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LE
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|701177.3.peg.2620
Escherichia coli O55:H7 str. CB9615 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LKP
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KVEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
L
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LMIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
L
I
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|340186.3.peg.4745
Escherichia coli E110019 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPTS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
AL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|340186.5.peg.5008
Escherichia coli E110019 (434-1005/1021)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPTS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
AL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|362663.8.peg.3389
Escherichia coli 536 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
RT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|362663.9.peg.3401
Escherichia coli 536 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
RT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|340197.3.peg.3941
Escherichia coli F11 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
RT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|340197.5.peg.4117
Escherichia coli F11 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
RT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|749550.3.peg.1298
Escherichia coli MS 200-1 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
RT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|701177.3.peg.4003
Escherichia coli O55:H7 str. CB9615 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPTS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
KA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
TN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|749527.3.peg.2193
Escherichia coli MS 21-1 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWVNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TAHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENIAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|6666666.5357.peg.2522
Escherichia coli TY-2482 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPTS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATPH
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|550676.3.peg.2372
Escherichia coli B185 (440-1021/1040)
I
G
FTIISLT
FS
L
I
AV
L
IP
L
L
F
M
G
D
IV
G
RLF
R
E
F
A
IT
LAV
A
I
LI
S
AV
V
S
L
T
LTP
M
M
CA
RM
L
S----Q
E
S
LRKQN
R
F
SRASEKM
F
DRIIAA
Y
GRG
L
A
K
V
L
NHPWLT
L
S
V
A
LST
L
LLSVL
L
WVF
I
P
KG
F
F
P
VQ
D
N
G
IIQGTL
Q
A
P
Q
S
S
S
FANMAQRQR
Q
VADV
I
L--QDPA
V
Q
S
LT
SFV
G
VDGT
---
NPS
L
N
SARLQ
I
N
LK
L
LD
E
-
R
D---DRVQ
KV
I
A
R
L
QTAVD
K
V
P
G
VDLFLQ
P
TQDLT
I
DT
Q
V
S
RTQYQFT
L
Q
-
--
A
TS
L
DA
L
STWVP
QL
MEK
L
QQL
P
Q-
L
SD
V
SS
D
W
QD
KGLVAY
VN
V
D
R
D
S
A
S
R
LG
I
S
M
A
D
V
DNA
L
Y
N
A
F
G
QRL
I
S---------T
I
Y
TQAN-Q
YR
VV
L
E
H
NTENTPGLAA
L
DTIR
L
T
S
SD
G
GV
VP
L
S
SI
A
KIEQRF
AP
LS
I
NHL
D
QF
P
VTT
I
SFN
V
P
D
NY
S
L
G
D
A
VQAIMDTEKTLN
LP
V
D
ITTQ
F
Q
G
ST
LAF
Q
SA
L
---
GS--TVW
L
IVA
A
V
V
A
M
Y
I
V
L
GI
LYES
FIH
P
IT
I
L
S
T
L
P
T
A
G
VG
A
LLA
LLIA
G
SE
L
DV
IAII
G
I
I
LL
IG
I
V
K
KNAI
M
M
I
D
FA
LAAERE
Q
----------
G
MSPR
D
A
I
Y
Q
A
CLL
R
F
RPILMT
T
LA
A
L
L
G
A
LPL
ML
STG
V
G
AE
LRRP
L
G
I
G
M
V
GG
LV
V
S
Q
VL
T
L
F
TT
P
VI
Y
L
L
fig|1040638.4.peg.1852
Escherichia coli O104:H4 str. LB226692 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPTS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|656408.3.peg.3689
Escherichia coli H591 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPTS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|595495.4.peg.650
Escherichia coli KO11 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPTS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|679207.4.peg.2470
Escherichia coli MS 107-1 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPTS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|679206.4.peg.4698
Escherichia coli MS 119-7 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPTS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|679204.3.peg.1000
Escherichia coli MS 145-7 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPTS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|409438.11.peg.3715
Escherichia coli SE11 (434-1005/1021)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPTS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|656443.3.peg.4164
Escherichia coli TA271 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPTS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|566546.3.peg.4708
Escherichia coli W (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPTS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|566546.4.peg.3495
Escherichia coli W (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPTS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|550676.3.peg.3416
Escherichia coli B185 (434-1005/1021)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPTS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|331111.12.peg.4004
Escherichia coli E24377A (434-1005/1021)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPTS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
S
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|331111.3.peg.1417
Escherichia coli E24377A (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPTS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
S
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|656419.3.peg.4247
Escherichia coli M718 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPTS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|749545.3.peg.3813
Escherichia coli MS 182-1 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPTS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|749532.3.peg.1210
Escherichia coli MS 78-1 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPTS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|340184.3.peg.4288
Escherichia coli B7A (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPTS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VHM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|340184.6.peg.4493
Escherichia coli B7A (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPTS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VHM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|585034.4.peg.3347
Escherichia coli IAI1 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
VY
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|585034.5.peg.3345
Escherichia coli IAI1 (434-1005/1021)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
VY
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|316401.4.peg.4000
Escherichia coli ETEC H10407 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
IS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|216593.1.peg.4876
Escherichia coli E2348/69 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
A
F
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|574521.7.peg.3616
Escherichia coli O127:H6 str. E2348/69 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
A
F
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|431946.3.peg.3234
Escherichia coli SE15 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQE
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|358709.5.peg.4812
Escherichia coli 101-1 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|670888.3.peg.2982
Escherichia coli 1827-70 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|670897.3.peg.4068
Escherichia coli 2362-75 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|525281.3.peg.3792
Escherichia coli 83972 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|655817.3.peg.3849
Escherichia coli ABU 83972 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|405955.13.peg.3687
Escherichia coli APEC O1 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|405955.9.peg.3079
Escherichia coli APEC O1 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|481805.3.peg.466
Escherichia coli ATCC 8739 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|481805.6.peg.468
Escherichia coli ATCC 8739 (434-1005/1021)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|199310.1.peg.3941
Escherichia coli CFT073 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|199310.4.peg.3796
Escherichia coli CFT073 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|585397.7.peg.3929
Escherichia coli ED1a (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|585397.9.peg.3926
Escherichia coli ED1a (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|331112.3.peg.3237
Escherichia coli HS (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|331112.6.peg.3374
Escherichia coli HS (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|714962.3.peg.3724
Escherichia coli IHE3034 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|656417.3.peg.4107
Escherichia coli M605 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|749546.3.peg.1815
Escherichia coli MS 185-1 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|749547.3.peg.1020
Escherichia coli MS 187-1 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|749528.3.peg.4231
Escherichia coli MS 45-1 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|753642.3.peg.4693
Escherichia coli NC101 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|685038.3.peg.3308
Escherichia coli O83:H1 str. NRG 857C (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|585035.6.peg.3587
Escherichia coli S88 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|656440.3.peg.3505
Escherichia coli TA206 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|869729.3.peg.6
Escherichia coli UM146 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|364106.7.peg.3660
Escherichia coli UTI89 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|364106.8.peg.3661
Escherichia coli UTI89 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|562.376.peg.1659
Escherichia coli WV_060327 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|595496.3.peg.3248
Escherichia coli BW2952 (434-1005/1021)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
L
Y
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|536056.3.peg.460
Escherichia coli DH1 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
L
Y
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|656414.3.peg.3746
Escherichia coli H736 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
L
Y
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|83333.1.peg.3208
Escherichia coli K12 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
L
Y
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|749538.3.peg.530
Escherichia coli MS 116-1 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
L
Y
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|749540.3.peg.3425
Escherichia coli MS 146-1 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
L
Y
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|749548.3.peg.3972
Escherichia coli MS 196-1 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
L
Y
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|316407.3.peg.3142
Escherichia coli W3110 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
L
Y
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|316385.5.peg.3394
Escherichia coli str. K-12 substr. DH10B (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
L
Y
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|316385.7.peg.3468
Escherichia coli str. K-12 substr. DH10B (434-1005/1021)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
L
Y
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|511145.12.peg.3365
Escherichia coli str. K-12 substr. MG1655 (428-999/1015)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
L
Y
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|511145.6.peg.3349
Escherichia coli str. K-12 substr. MG1655 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
L
Y
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|344601.3.peg.4583
Escherichia coli B171 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMEFG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|344601.5.peg.4834
Escherichia coli B171 (434-1005/1021)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMEFG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|340185.3.peg.4834
Escherichia coli E22 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMEFG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|340185.4.peg.5107
Escherichia coli E22 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMEFG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|562.375.peg.922
Escherichia coli EC4100B (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGNENSAE
A
V
I
H
RA
KMEFG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|679205.4.peg.2758
Escherichia coli MS 124-1 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMEFG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|749533.3.peg.2406
Escherichia coli MS 84-1 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMEFG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|585395.4.peg.4189
Escherichia coli O103:H2 str. 12009 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMEFG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|573235.3.peg.4477
Escherichia coli O26:H11 str. 11368 (434-1005/1021)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMEFG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|585396.4.peg.511
Escherichia coli O111:H- str. 11128 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDID
R
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|573235.3.peg.503
Escherichia coli O26:H11 str. 11368 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDID
R
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749531.3.peg.2480
Escherichia coli MS 69-1 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
S
F
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TAHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--Q
LP
A
G
IDYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|550677.3.peg.3822
Escherichia coli B354 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TAHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--Q
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|656379.3.peg.4005
Escherichia coli FVEC1302 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TAHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--Q
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|656380.3.peg.3924
Escherichia coli FVEC1412 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TAHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--Q
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|656393.3.peg.4313
Escherichia coli H299 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TAHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--Q
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|749549.3.peg.2017
Escherichia coli MS 198-1 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TAHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--Q
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|656437.3.peg.3690
Escherichia coli TA143 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TAHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--Q
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|656444.3.peg.4526
Escherichia coli TA280 (379-950/966)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TAHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--Q
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|585056.7.peg.3922
Escherichia coli UMN026 (434-1005/1021)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TAHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--Q
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|585396.4.peg.4236
Escherichia coli O111:H- str. 11128 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMEFG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
EHY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|216592.1.peg.4754
Escherichia coli 042 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
EH
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQRVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|216592.3.peg.523
Escherichia coli 042 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
EH
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQRVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|216592.1.peg.4196
Escherichia coli 042 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
K
-
R
NGDKNSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TAHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--Q
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|216592.3.peg.3689
Escherichia coli 042 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
K
-
R
NGDKNSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TAHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--Q
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|585057.4.peg.3895
Escherichia coli IAI39 (127-698/714)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--Q
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|585057.6.peg.3904
Escherichia coli IAI39 (127-698/714)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--Q
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|344610.3.peg.4782
Escherichia coli 53638 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VN
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|344610.7.peg.2970
Escherichia coli 53638 (434-1005/1021)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
SGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VN
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|585055.6.peg.3718
Escherichia coli 55989 (434-1005/1021)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPTS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
H
PILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|585055.8.peg.3721
Escherichia coli 55989 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPTS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NSDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
R
L
H
PILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|362663.8.peg.524
Escherichia coli 536 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
N
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|362663.9.peg.524
Escherichia coli 536 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
N
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|340197.3.peg.3791
Escherichia coli F11 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
N
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|340197.5.peg.3969
Escherichia coli F11 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
N
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749550.3.peg.4715
Escherichia coli MS 200-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
N
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749550.3.peg.4714
Escherichia coli MS 200-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
N
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|670897.3.peg.255
Escherichia coli 2362-75 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|525281.3.peg.2443
Escherichia coli 83972 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|655817.3.peg.581
Escherichia coli ABU 83972 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|655817.3.peg.582
Escherichia coli ABU 83972 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|199310.1.peg.558
Escherichia coli CFT073 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|199310.4.peg.544
Escherichia coli CFT073 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|216593.1.peg.3137
Escherichia coli E2348/69 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|585397.7.peg.487
Escherichia coli ED1a (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|585397.9.peg.489
Escherichia coli ED1a (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|656379.3.peg.947
Escherichia coli FVEC1302 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|656380.3.peg.1096
Escherichia coli FVEC1412 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|656417.3.peg.605
Escherichia coli M605 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|656417.3.peg.606
Escherichia coli M605 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749546.3.peg.3573
Escherichia coli MS 185-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749546.3.peg.3574
Escherichia coli MS 185-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749549.3.peg.4337
Escherichia coli MS 198-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749549.3.peg.4338
Escherichia coli MS 198-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749527.3.peg.734
Escherichia coli MS 21-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749527.3.peg.733
Escherichia coli MS 21-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749528.3.peg.3597
Escherichia coli MS 45-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749528.3.peg.3596
Escherichia coli MS 45-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749531.3.peg.2785
Escherichia coli MS 69-1 (223-795/825)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|753642.3.peg.1171
Escherichia coli NC101 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|753642.3.peg.1170
Escherichia coli NC101 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|574521.7.peg.427
Escherichia coli O127:H6 str. E2348/69 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|431946.3.peg.438
Escherichia coli SE15 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|656437.3.peg.547
Escherichia coli TA143 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|656437.3.peg.548
Escherichia coli TA143 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|656444.3.peg.939
Escherichia coli TA280 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|656444.3.peg.940
Escherichia coli TA280 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|585056.7.peg.707
Escherichia coli UMN026 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|562.376.peg.689
Escherichia coli WV_060327 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|562.376.peg.688
Escherichia coli WV_060327 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTNY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|413997.3.peg.3273
Escherichia coli B str. REL606 (434-1005/1021)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
H
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|511693.5.peg.3285
Escherichia coli BL21 (447-1018/1034)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
H
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|469008.4.peg.492
Escherichia coli BL21(DE3) (434-1005/1021)
MV
L
S
AVFIPM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TL
L
KPVS-A
EH
HENKG
GF
FGWFNTT
F
DHSVNH
Y
TNS
V
G
KIL
GSTGRY
L
L
I
Y
ALI
V
AGMVV
L
FLR
LP
SS
FLP
EE
D
Q
G
VFLTMI
Q
L
P
A
G
A
T
QERTQKVLD
Q
VTDY
Y
LKNEKAN
V
E
SVF
TVN
G
FSFS
---
GQA
QN
AGMAF
V
S
LKP
WE
E
-
R
NGDENSAE
A
V
I
H
RA
KMELG
KI
R
-
-DGFVI
P
FNMPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
DA
L
TQARN
QL
LGM
A
AQH
P
AS
L
VS
V
RP
N
G
LE
DTAQFK
LE
V
DQ
E
KA
Q
ALGVS
L
S
DI
NQT
I
S
TA
L
G
GTY
V
NDFIDRGRVKK
VY
VQADAK
F
R
ML
P
E
D
----------
V
DKLY
V
R
S
AN
G
EM
VPFS
AF
T
TSHWVY
GS
PR
L
ERY
N
GL
P
SME
I
QGE
A
A
P
GT
S
S
G
D
A
MALMENLAS--K
LP
A
G
IGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPA
L
VAI
S
F
V
V
VFL
C
L
AA
LYES
WSI
P
VS
VML
V
VP
L
G
I
VG
V
LLA
ATLF
N
QK
NDV
YFMV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMEK
E
----------
G
KGVV
EA
T
L
M
A
VRM
H
L
RPILMT
S
LA
F
I
L
G
V
LPL
AI
S
N
GAGSG
AQNA
VG
I
GVMGGM
V
S
A
T
L
LAI
fig|1040638.4.peg.5156
Escherichia coli O104:H4 str. LB226692 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|6666666.5357.peg.957
Escherichia coli TY-2482 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|358709.5.peg.2093
Escherichia coli 101-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|562.371.peg.2717
Escherichia coli 1044A (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|562.371.peg.2718
Escherichia coli 1044A (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|562.373.peg.3279
Escherichia coli 1125A (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|562.373.peg.3278
Escherichia coli 1125A (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|562.372.peg.1448
Escherichia coli 1212A (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|562.372.peg.1449
Escherichia coli 1212A (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|670888.3.peg.1046
Escherichia coli 1827-70 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|344610.3.peg.1469
Escherichia coli 53638 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|344610.7.peg.1212
Escherichia coli 53638 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|562.374.peg.5528
Escherichia coli 536A (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|562.374.peg.5527
Escherichia coli 536A (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|585055.6.peg.484
Escherichia coli 55989 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|585055.8.peg.485
Escherichia coli 55989 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|405955.13.peg.465
Escherichia coli APEC O1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|405955.9.peg.379
Escherichia coli APEC O1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|481805.3.peg.3379
Escherichia coli ATCC 8739 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|481805.6.peg.3366
Escherichia coli ATCC 8739 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|550672.3.peg.482
Escherichia coli B088 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|344601.3.peg.3344
Escherichia coli B171 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|344601.5.peg.3497
Escherichia coli B171 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|550676.3.peg.1259
Escherichia coli B185 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|550677.3.peg.900
Escherichia coli B354 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|340184.3.peg.2600
Escherichia coli B7A (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|340184.6.peg.2719
Escherichia coli B7A (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|511693.5.peg.449
Escherichia coli BL21 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|469008.4.peg.3301
Escherichia coli BL21(DE3) (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|595496.3.peg.383
Escherichia coli BW2952 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|536056.3.peg.3327
Escherichia coli DH1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|340186.3.peg.877
Escherichia coli E110019 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|340186.5.peg.915
Escherichia coli E110019 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|340185.3.peg.2553
Escherichia coli E22 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|340185.4.peg.2693
Escherichia coli E22 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|331111.12.peg.806
Escherichia coli E24377A (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|331111.3.peg.3035
Escherichia coli E24377A (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|562.375.peg.3740
Escherichia coli EC4100B (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|562.375.peg.3741
Escherichia coli EC4100B (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|316401.4.peg.590
Escherichia coli ETEC H10407 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|316401.4.peg.591
Escherichia coli ETEC H10407 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|656393.3.peg.1114
Escherichia coli H299 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|656393.3.peg.1115
Escherichia coli H299 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|656408.3.peg.403
Escherichia coli H591 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|656408.3.peg.404
Escherichia coli H591 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|656414.3.peg.657
Escherichia coli H736 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|656414.3.peg.658
Escherichia coli H736 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|331112.3.peg.501
Escherichia coli HS (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|331112.6.peg.526
Escherichia coli HS (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|585034.4.peg.460
Escherichia coli IAI1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|585034.5.peg.459
Escherichia coli IAI1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|714962.3.peg.455
Escherichia coli IHE3034 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|83333.1.peg.458
Escherichia coli K12 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|595495.4.peg.406
Escherichia coli KO11 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|595495.4.peg.405
Escherichia coli KO11 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|656419.3.peg.669
Escherichia coli M718 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|656419.3.peg.670
Escherichia coli M718 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|679207.4.peg.3163
Escherichia coli MS 107-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|679207.4.peg.3162
Escherichia coli MS 107-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749537.3.peg.1844
Escherichia coli MS 115-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749537.3.peg.1843
Escherichia coli MS 115-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749538.3.peg.1375
Escherichia coli MS 116-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749538.3.peg.1374
Escherichia coli MS 116-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|679206.4.peg.86
Escherichia coli MS 119-7 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|679206.4.peg.85
Escherichia coli MS 119-7 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|679205.4.peg.168
Escherichia coli MS 124-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|679205.4.peg.169
Escherichia coli MS 124-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|679204.3.peg.1938
Escherichia coli MS 145-7 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|679204.3.peg.1937
Escherichia coli MS 145-7 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749540.3.peg.3781
Escherichia coli MS 146-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749540.3.peg.3782
Escherichia coli MS 146-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749545.3.peg.2239
Escherichia coli MS 182-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749545.3.peg.2240
Escherichia coli MS 182-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749547.3.peg.2445
Escherichia coli MS 187-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749547.3.peg.2444
Escherichia coli MS 187-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749548.3.peg.2591
Escherichia coli MS 196-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749548.3.peg.2590
Escherichia coli MS 196-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749532.3.peg.4713
Escherichia coli MS 78-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749532.3.peg.4712
Escherichia coli MS 78-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749533.3.peg.1335
Escherichia coli MS 84-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749533.3.peg.1334
Escherichia coli MS 84-1 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|585395.4.peg.462
Escherichia coli O103:H2 str. 12009 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|83334.1.peg.592
Escherichia coli O157:H7 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|155864.1.peg.511
Escherichia coli O157:H7 EDL933 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|155864.8.peg.521
Escherichia coli O157:H7 EDL933 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|444454.5.peg.4994
Escherichia coli O157:H7 str. EC4024 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|444449.5.peg.5331
Escherichia coli O157:H7 str. EC4042 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|444448.5.peg.3206
Escherichia coli O157:H7 str. EC4045 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|444453.5.peg.547
Escherichia coli O157:H7 str. EC4076 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|444452.5.peg.979
Escherichia coli O157:H7 str. EC4113 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|444450.8.peg.668
Escherichia coli O157:H7 str. EC4115 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|444451.5.peg.4632
Escherichia coli O157:H7 str. EC4196 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|444447.5.peg.3380
Escherichia coli O157:H7 str. EC4206 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|478004.5.peg.1376
Escherichia coli O157:H7 str. EC4401 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|478005.5.peg.2407
Escherichia coli O157:H7 str. EC4486 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|478006.5.peg.940
Escherichia coli O157:H7 str. EC4501 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|478007.5.peg.866
Escherichia coli O157:H7 str. EC508 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|478008.5.peg.1608
Escherichia coli O157:H7 str. EC869 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|637388.3.peg.1003
Escherichia coli O157:H7 str. FRIK2000 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|570506.3.peg.2206
Escherichia coli O157:H7 str. FRIK966 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|386585.9.peg.620
Escherichia coli O157:H7 str. Sakai (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|544404.4.peg.532
Escherichia coli O157:H7 str. TW14359 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|502346.5.peg.691
Escherichia coli O157:H7 str. TW14588 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|701177.3.peg.573
Escherichia coli O55:H7 str. CB9615 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|685038.3.peg.439
Escherichia coli O83:H1 str. NRG 857C (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|585035.6.peg.458
Escherichia coli S88 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|409438.11.peg.614
Escherichia coli SE11 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|439855.10.peg.678
Escherichia coli SMS-3-5 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|656440.3.peg.339
Escherichia coli TA206 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|656440.3.peg.340
Escherichia coli TA206 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|656443.3.peg.717
Escherichia coli TA271 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|656443.3.peg.718
Escherichia coli TA271 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|869729.3.peg.3222
Escherichia coli UM146 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|869729.3.peg.3221
Escherichia coli UM146 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|364106.7.peg.596
Escherichia coli UTI89 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|364106.8.peg.594
Escherichia coli UTI89 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|566546.3.peg.2322
Escherichia coli W (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|566546.3.peg.2321
Escherichia coli W (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|566546.4.peg.539
Escherichia coli W (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|316407.3.peg.447
Escherichia coli W3110 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|316385.5.peg.416
Escherichia coli str. K-12 substr. DH10B (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|316385.7.peg.423
Escherichia coli str. K-12 substr. DH10B (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|511145.12.peg.480
Escherichia coli str. K-12 substr. MG1655 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|511145.6.peg.475
Escherichia coli str. K-12 substr. MG1655 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
NDV
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|413997.3.peg.444
Escherichia coli B str. REL606 (447-1019/1049)
MV
L
S
AVF
V
PM
A
F
F
GG
ST
GAIYR
Q
FSIT
IVS
AM
AL
SVLVAL
I
LTP
A
LCA
TM
L
KPIAKG
D
H
GEGKK
GF
FGWFNRM
F
EKSTHH
Y
TDS
V
G
G
IL
RSTGRY
L
V
L
Y
LII
V
VGMAY
L
FVR
LP
SS
FLP
DE
D
Q
G
VFMTMV
Q
L
P
A
G
A
T
QERTQKVLN
E
VTHY
Y
LTKEKNN
V
E
SVF
AVN
G
FGFA
---
GRG
QN
TGIAF
V
S
LK
D
WA
D
-
R
PGEENKVE
AI
T
M
RA
TRAFS
Q
I
K
-
-DAMVF
A
FNLPA
I
VE
L
G
T
ATGFDFE
L
I
D
QA
G
LG
H
EK
L
TQARN
QL
LAE
A
AKH
P
DM
L
TS
V
RP
N
G
LE
DTPQFK
IDIDQ
E
KA
Q
ALGVSI
N
DI
NTT
L
G
A
A
W
G
GSY
V
NDFIDRGRVKK
VY
VMSEAK
YR
ML
PD
D
----------
I
GDWY
V
R
A
AD
G
QM
VPFS
AF
S
SSRWEY
GS
PR
L
ERY
N
GL
P
SME
I
LGQ
A
A
P
GK
S
T
G
E
A
MELMEQLAS--K
LP
T
G
VGYD
W
T
G
--
MSY
Q
ER
L
---
SGNQAPS
L
YAI
S
L
I
V
VFL
C
L
AA
LYES
WSI
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
ATFR
G
LT
ND
I
YFQV
G
L
L
TT
IGL
S
AKNAILIV
E
FA
KDLMDK
E
----------
G
KGLI
EA
T
L
D
A
VRM
R
L
RPILMT
S
LA
F
I
L
G
V
M
PL
VI
STGAGSG
AQNA
VG
T
GVMGGM
V
T
A
T
VLAI
fig|749548.3.peg.1997
Escherichia coli MS 196-1 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKGVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|216593.1.peg.2195
Escherichia coli E2348/69 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GLHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|574521.7.peg.2753
Escherichia coli O127:H6 str. E2348/69 (319-901/909)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GLHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|155864.8.peg.3235
Escherichia coli O157:H7 EDL933 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTXKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|656393.3.peg.3483
Escherichia coli H299 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
M
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|670888.3.peg.3828
Escherichia coli 1827-70 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
K-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|562.371.peg.5329
Escherichia coli 1044A (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|562.373.peg.3655
Escherichia coli 1125A (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|562.372.peg.1878
Escherichia coli 1212A (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|562.374.peg.3080
Escherichia coli 536A (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|481805.3.peg.1293
Escherichia coli ATCC 8739 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|481805.6.peg.1292
Escherichia coli ATCC 8739 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|413997.3.peg.2471
Escherichia coli B str. REL606 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|511693.5.peg.2483
Escherichia coli BL21 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|469008.4.peg.1253
Escherichia coli BL21(DE3) (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|595496.3.peg.2446
Escherichia coli BW2952 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|536056.3.peg.1263
Escherichia coli DH1 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|316401.4.peg.2937
Escherichia coli ETEC H10407 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|656414.3.peg.2834
Escherichia coli H736 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|83333.1.peg.2438
Escherichia coli K12 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|749538.3.peg.4763
Escherichia coli MS 116-1 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|749540.3.peg.1070
Escherichia coli MS 146-1 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|749544.3.peg.2847
Escherichia coli MS 175-1 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|749547.3.peg.2320
Escherichia coli MS 187-1 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|585396.4.peg.3291
Escherichia coli O111:H- str. 11128 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|83334.1.peg.3329
Escherichia coli O157:H7 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|155864.1.peg.3330
Escherichia coli O157:H7 EDL933 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|444454.5.peg.2351
Escherichia coli O157:H7 str. EC4024 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|444449.5.peg.1816
Escherichia coli O157:H7 str. EC4042 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|444448.5.peg.570
Escherichia coli O157:H7 str. EC4045 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|444453.5.peg.52
Escherichia coli O157:H7 str. EC4076 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|444452.5.peg.1540
Escherichia coli O157:H7 str. EC4113 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|444450.8.peg.3659
Escherichia coli O157:H7 str. EC4115 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|444451.5.peg.1310
Escherichia coli O157:H7 str. EC4196 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|444447.5.peg.710
Escherichia coli O157:H7 str. EC4206 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|478004.5.peg.2971
Escherichia coli O157:H7 str. EC4401 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|478005.5.peg.2541
Escherichia coli O157:H7 str. EC4486 (387-969/977)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|478006.5.peg.1579
Escherichia coli O157:H7 str. EC4501 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|478007.5.peg.1624
Escherichia coli O157:H7 str. EC508 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|478008.5.peg.3015
Escherichia coli O157:H7 str. EC869 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|637388.3.peg.131
Escherichia coli O157:H7 str. FRIK2000 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|570506.3.peg.5202
Escherichia coli O157:H7 str. FRIK966 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|386585.9.peg.3479
Escherichia coli O157:H7 str. Sakai (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|544404.4.peg.3462
Escherichia coli O157:H7 str. TW14359 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|502346.5.peg.3954
Escherichia coli O157:H7 str. TW14588 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|573235.3.peg.3579
Escherichia coli O26:H11 str. 11368 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|701177.3.peg.3023
Escherichia coli O55:H7 str. CB9615 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|316407.3.peg.2391
Escherichia coli W3110 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|316385.5.peg.2600
Escherichia coli str. K-12 substr. DH10B (387-969/977)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|316385.7.peg.2658
Escherichia coli str. K-12 substr. DH10B (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|511145.12.peg.2564
Escherichia coli str. K-12 substr. MG1655 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|511145.6.peg.2550
Escherichia coli str. K-12 substr. MG1655 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|656379.3.peg.3043
Escherichia coli FVEC1302 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
EA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|656380.3.peg.2543
Escherichia coli FVEC1412 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
EA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|749549.3.peg.1756
Escherichia coli MS 198-1 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
EA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|585056.7.peg.2966
Escherichia coli UMN026 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
EA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|344610.3.peg.415
Escherichia coli 53638 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
R
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
T
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|344610.7.peg.3865
Escherichia coli 53638 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
R
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
T
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|1040638.4.peg.2882
Escherichia coli O104:H4 str. LB226692 (178-760/768)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|6666666.5357.peg.4416
Escherichia coli TY-2482 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|670897.3.peg.3434
Escherichia coli 2362-75 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|585055.6.peg.2782
Escherichia coli 55989 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|585055.8.peg.2786
Escherichia coli 55989 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|405955.13.peg.2715
Escherichia coli APEC O1 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|405955.9.peg.2235
Escherichia coli APEC O1 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|550676.3.peg.1663
Escherichia coli B185 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|550677.3.peg.2332
Escherichia coli B354 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|340186.3.peg.1585
Escherichia coli E110019 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|340186.5.peg.1634
Escherichia coli E110019 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|340185.3.peg.3122
Escherichia coli E22 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|340185.4.peg.3285
Escherichia coli E22 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|340197.3.peg.3049
Escherichia coli F11 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
H
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|340197.5.peg.3187
Escherichia coli F11 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
H
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|585034.4.peg.2485
Escherichia coli IAI1 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|585034.5.peg.2483
Escherichia coli IAI1 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|585057.4.peg.2710
Escherichia coli IAI39 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|585057.6.peg.2713
Escherichia coli IAI39 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|714962.3.peg.2822
Escherichia coli IHE3034 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|656417.3.peg.3145
Escherichia coli M605 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|656419.3.peg.3228
Escherichia coli M718 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|749550.3.peg.5137
Escherichia coli MS 200-1 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|749527.3.peg.4775
Escherichia coli MS 21-1 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|753642.3.peg.2636
Escherichia coli NC101 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|585395.4.peg.3117
Escherichia coli O103:H2 str. 12009 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|585035.6.peg.2620
Escherichia coli S88 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|431946.3.peg.2428
Escherichia coli SE15 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|439855.10.peg.2775
Escherichia coli SMS-3-5 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|656437.3.peg.2792
Escherichia coli TA143 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|869729.3.peg.928
Escherichia coli UM146 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|364106.7.peg.2801
Escherichia coli UTI89 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|364106.8.peg.2801
Escherichia coli UTI89 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|562.376.peg.4385
Escherichia coli WV_060327 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|358709.5.peg.2250
Escherichia coli 101-1 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQPLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
Q
I
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|749546.3.peg.459
Escherichia coli MS 185-1 (447-1029/1037)
MV
L
S
AVF
V
PM
T
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNSER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
RSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|679205.4.peg.1336
Escherichia coli MS 124-1 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVT
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|749533.3.peg.1535
Escherichia coli MS 84-1 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVT
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|525281.3.peg.4252
Escherichia coli 83972 (387-969/977)
MV
L
S
AVF
V
PM
T
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNSER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|655817.3.peg.2900
Escherichia coli ABU 83972 (387-969/977)
MV
L
S
AVF
V
PM
T
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNSER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|199310.1.peg.2922
Escherichia coli CFT073 (447-1029/1037)
MV
L
S
AVF
V
PM
T
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNSER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|199310.4.peg.2827
Escherichia coli CFT073 (447-1029/1037)
MV
L
S
AVF
V
PM
T
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNSER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|749528.3.peg.2359
Escherichia coli MS 45-1 (447-1029/1037)
MV
L
S
AVF
V
PM
T
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNSER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|550672.3.peg.2189
Escherichia coli B088 (319-901/909)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|340184.3.peg.2721
Escherichia coli B7A (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|340184.6.peg.2848
Escherichia coli B7A (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|562.375.peg.3443
Escherichia coli EC4100B (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|656408.3.peg.2751
Escherichia coli H591 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|595495.4.peg.2507
Escherichia coli KO11 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|679206.4.peg.651
Escherichia coli MS 119-7 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|749532.3.peg.3273
Escherichia coli MS 78-1 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|409438.11.peg.2918
Escherichia coli SE11 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|566546.3.peg.2692
Escherichia coli W (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|566546.4.peg.2662
Escherichia coli W (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|585397.7.peg.2914
Escherichia coli ED1a (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNSER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|585397.9.peg.2911
Escherichia coli ED1a (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNSER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|685038.3.peg.2506
Escherichia coli O83:H1 str. NRG 857C (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNSER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|749531.3.peg.2713
Escherichia coli MS 69-1 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
E
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|216592.1.peg.5437
Escherichia coli 042 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
S
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|216592.3.peg.2793
Escherichia coli 042 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
A
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
S
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|749545.3.peg.420
Escherichia coli MS 182-1 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
PT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|679207.4.peg.2750
Escherichia coli MS 107-1 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATI
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|331111.12.peg.3018
Escherichia coli E24377A (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDI
E
Q
R
KA
Q
ALGV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|331111.3.peg.472
Escherichia coli E24377A (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LAL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDI
E
Q
R
KA
Q
ALGV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|679204.3.peg.1632
Escherichia coli MS 145-7 (447-1029/1037)
MV
L
S
AVF
V
PM
A
F
F
GG
TT
GAIYR
Q
FSIT
IVA
AM
VL
SVLVA
M
I
LTP
A
LCA
TL
L
KPLKKG
EH
H-GQK
GF
FAWFNQM
F
NRNAER
Y
EKG
V
A
KIL
HRSLRW
I
V
I
Y
VLL
L
GGMVF
L
FLR
LP
TS
FLP
LE
D
R
G
MFTTSV
Q
L
P
S
G
S
T
QQQTLKVVE
Q
IEKY
Y
FTHEKDN
I
M
SVF
ATV
G
SGPG
---
GNG
QN
VARMF
I
R
LK
D
WS
E
-
R
DSKTGTSF
AII
E
RA
TKAFN
KI
K
-
-EARVI
A
SSPPA
I
SG
L
G
S
SAGFDME
L
Q
D
HA
G
AG
H
DA
L
MAARN
QL
LVL
A
AEN
P
E-
L
TR
V
RH
N
G
L
D
DSPQLQ
IDIDQ
R
KA
Q
ALGV
D
I
D
DI
NDT
L
Q
TA
W
G
SSY
V
NDFMDRGRVKK
VY
VQAAAP
YR
ML
PD
D
----------
I
NLWY
V
R
N
KD
G
GM
VPFS
AF
A
TSRWET
GS
PR
L
ERY
N
GY
S
AVE
I
VGE
A
A
P
GV
S
T
G
T
A
MDIMESLVK--Q
LP
N
G
FGLE
W
T
A
--
MSY
Q
ER
L
---
SGAQAPA
L
YAI
S
L
L
V
VFL
C
L
AA
LYES
WSV
P
FS
VML
V
VP
L
G
V
I
G
A
LLA
TWMR
G
LE
NDV
YFQV
G
L
L
TV
IGL
S
AKNAILIV
E
FA
NE-MNQ
K
----------
G
HDLF
EA
T
L
H
A
CRQ
R
L
RPILMT
S
LA
F
I
F
G
V
LP
M
AT
STGAGSG
GQHA
VG
T
GVMGGMI
S
A
T
I
LAI
Y
FV
P
LF
F
V
L
VRRR
fig|405955.13.peg.1406
Escherichia coli APEC O1 (438-1023/1035)
E
I
SG
AL
VAIA
LV
L
S
AVF
L
PM
A
F
F
GG
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPP-
--
--HKK
GF
FGAFNRF
Y
RRTEDK
Y
QRG
V
I
Y
V
L
RRAART
M
G
L
Y
VVL
G
GGMAL
M
MWK
LP
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IVDW
F
LINEKAN
T
D
V
I
F
TVD
G
FSFS
---
GSG
QN
TGMAF
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELG
T
I
R
-
-DATVF
A
MTPPA
V
DG
L
G
Q
SNGFTFE
L
L
A
NG
G
AD
R
ET
L
LQMRN
QL
IEK
A
NQS
P
E-
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DID
S
N
KA
V
S
LG
L
S
L
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRVKK
VY
IQGDSE
F
R
SA
P
S
D
----------
L
GKWF
V
R
G
SD
N
AM
T
PFS
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QGE
N
A
T
GF
S
S
G
D
A
MTKMEELAN--S
LP
A
G
TTWA
W
S
G
--
LSL
Q
EK
L
---
ASGQALS
L
YAV
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
EA-AVA
E
----------
G
YSLS
R
A
A
L
R
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TGAG
A
N
SRIA
I
G
T
G
II
GG
T
L
T
A
T
L
LAIF
FV
P
LF
F
V
L
V
fig|405955.9.peg.1156
Escherichia coli APEC O1 (438-1023/1035)
E
I
SG
AL
VAIA
LV
L
S
AVF
L
PM
A
F
F
GG
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPP-
--
--HKK
GF
FGAFNRF
Y
RRTEDK
Y
QRG
V
I
Y
V
L
RRAART
M
G
L
Y
VVL
G
GGMAL
M
MWK
LP
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IVDW
F
LINEKAN
T
D
V
I
F
TVD
G
FSFS
---
GSG
QN
TGMAF
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELG
T
I
R
-
-DATVF
A
MTPPA
V
DG
L
G
Q
SNGFTFE
L
L
A
NG
G
AD
R
ET
L
LQMRN
QL
IEK
A
NQS
P
E-
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DID
S
N
KA
V
S
LG
L
S
L
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRVKK
VY
IQGDSE
F
R
SA
P
S
D
----------
L
GKWF
V
R
G
SD
N
AM
T
PFS
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QGE
N
A
T
GF
S
S
G
D
A
MTKMEELAN--S
LP
A
G
TTWA
W
S
G
--
LSL
Q
EK
L
---
ASGQALS
L
YAV
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
EA-AVA
E
----------
G
YSLS
R
A
A
L
R
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TGAG
A
N
SRIA
I
G
T
G
II
GG
T
L
T
A
T
L
LAIF
FV
P
LF
F
V
L
V
fig|714962.3.peg.1532
Escherichia coli IHE3034 (438-1023/1035)
E
I
SG
AL
VAIA
LV
L
S
AVF
L
PM
A
F
F
GG
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPP-
--
--HKK
GF
FGAFNRF
Y
RRTEDK
Y
QRG
V
I
Y
V
L
RRAART
M
G
L
Y
VVL
G
GGMAL
M
MWK
LP
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IVDW
F
LINEKAN
T
D
V
I
F
TVD
G
FSFS
---
GSG
QN
TGMAF
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELG
T
I
R
-
-DATVF
A
MTPPA
V
DG
L
G
Q
SNGFTFE
L
L
A
NG
G
AD
R
ET
L
LQMRN
QL
IEK
A
NQS
P
E-
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DID
S
N
KA
V
S
LG
L
S
L
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRVKK
VY
IQGDSE
F
R
SA
P
S
D
----------
L
GKWF
V
R
G
SD
N
AM
T
PFS
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QGE
N
A
T
GF
S
S
G
D
A
MTKMEELAN--S
LP
A
G
TTWA
W
S
G
--
LSL
Q
EK
L
---
ASGQALS
L
YAV
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
EA-AVA
E
----------
G
YSLS
R
A
A
L
R
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TGAG
A
N
SRIA
I
G
T
G
II
GG
T
L
T
A
T
L
LAIF
FV
P
LF
F
V
L
V
fig|585035.6.peg.1423
Escherichia coli S88 (438-1023/1035)
E
I
SG
AL
VAIA
LV
L
S
AVF
L
PM
A
F
F
GG
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPP-
--
--HKK
GF
FGAFNRF
Y
RRTEDK
Y
QRG
V
I
Y
V
L
RRAART
M
G
L
Y
VVL
G
GGMAL
M
MWK
LP
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IVDW
F
LINEKAN
T
D
V
I
F
TVD
G
FSFS
---
GSG
QN
TGMAF
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELG
T
I
R
-
-DATVF
A
MTPPA
V
DG
L
G
Q
SNGFTFE
L
L
A
NG
G
AD
R
ET
L
LQMRN
QL
IEK
A
NQS
P
E-
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DID
S
N
KA
V
S
LG
L
S
L
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRVKK
VY
IQGDSE
F
R
SA
P
S
D
----------
L
GKWF
V
R
G
SD
N
AM
T
PFS
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QGE
N
A
T
GF
S
S
G
D
A
MTKMEELAN--S
LP
A
G
TTWA
W
S
G
--
LSL
Q
EK
L
---
ASGQALS
L
YAV
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
EA-AVA
E
----------
G
YSLS
R
A
A
L
R
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TGAG
A
N
SRIA
I
G
T
G
II
GG
T
L
T
A
T
L
LAIF
FV
P
LF
F
V
L
V
fig|364106.7.peg.1603
Escherichia coli UTI89 (438-1023/1035)
E
I
SG
AL
VAIA
LV
L
S
AVF
L
PM
A
F
F
GG
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPP-
--
--HKK
GF
FGAFNRF
Y
RRTEDK
Y
QRG
V
I
Y
V
L
RRAART
M
G
L
Y
VVL
G
GGMAL
M
MWK
LP
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IVDW
F
LINEKAN
T
D
V
I
F
TVD
G
FSFS
---
GSG
QN
TGMAF
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELG
T
I
R
-
-DATVF
A
MTPPA
V
DG
L
G
Q
SNGFTFE
L
L
A
NG
G
AD
R
ET
L
LQMRN
QL
IEK
A
NQS
P
E-
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DID
S
N
KA
V
S
LG
L
S
L
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRVKK
VY
IQGDSE
F
R
SA
P
S
D
----------
L
GKWF
V
R
G
SD
N
AM
T
PFS
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QGE
N
A
T
GF
S
S
G
D
A
MTKMEELAN--S
LP
A
G
TTWA
W
S
G
--
LSL
Q
EK
L
---
ASGQALS
L
YAV
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
EA-AVA
E
----------
G
YSLS
R
A
A
L
R
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TGAG
A
N
SRIA
I
G
T
G
II
GG
T
L
T
A
T
L
LAIF
FV
P
LF
F
V
L
V
fig|364106.8.peg.1603
Escherichia coli UTI89 (438-1023/1035)
E
I
SG
AL
VAIA
LV
L
S
AVF
L
PM
A
F
F
GG
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPP-
--
--HKK
GF
FGAFNRF
Y
RRTEDK
Y
QRG
V
I
Y
V
L
RRAART
M
G
L
Y
VVL
G
GGMAL
M
MWK
LP
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IVDW
F
LINEKAN
T
D
V
I
F
TVD
G
FSFS
---
GSG
QN
TGMAF
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELG
T
I
R
-
-DATVF
A
MTPPA
V
DG
L
G
Q
SNGFTFE
L
L
A
NG
G
AD
R
ET
L
LQMRN
QL
IEK
A
NQS
P
E-
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DID
S
N
KA
V
S
LG
L
S
L
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRVKK
VY
IQGDSE
F
R
SA
P
S
D
----------
L
GKWF
V
R
G
SD
N
AM
T
PFS
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QGE
N
A
T
GF
S
S
G
D
A
MTKMEELAN--S
LP
A
G
TTWA
W
S
G
--
LSL
Q
EK
L
---
ASGQALS
L
YAV
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
EA-AVA
E
----------
G
YSLS
R
A
A
L
R
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TGAG
A
N
SRIA
I
G
T
G
II
GG
T
L
T
A
T
L
LAIF
FV
P
LF
F
V
L
V
fig|749527.3.peg.410
Escherichia coli MS 21-1 (438-1023/1035)
E
I
SG
AL
VAIA
LV
L
S
AVF
L
PM
A
F
F
GG
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPP-
--
--HKK
GF
FGAFNRF
Y
RRTEDK
Y
QRG
V
I
Y
V
L
RRAART
M
G
L
Y
VVL
G
GGMAL
M
MWK
LP
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IVDW
F
LINEKAN
T
D
V
I
F
TVD
G
FSFS
---
GSG
QN
TGMAF
V
S
LK
N
WS
Q
-
R
KGTENTAQ
AI
A
L
RA
TKELG
T
I
R
-
-DATVF
A
MTPPA
V
DG
L
G
Q
SNGFTFE
L
L
A
NG
G
TD
R
ET
L
LQMRN
QL
IEK
A
NQS
P
E-
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DID
S
N
KA
V
S
LG
L
S
L
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRVKK
VY
IQGDSE
F
R
SA
P
S
D
----------
L
GKWF
V
R
G
SD
N
AM
T
PFS
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QGE
N
A
T
GF
S
S
G
D
A
MTKMEELAN--S
LP
A
G
TTWA
W
S
G
--
LSL
Q
EK
L
---
ASGQALS
L
YAV
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
EA-AVA
E
----------
G
YSLS
R
A
A
L
R
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TGAG
A
N
SRIA
I
G
T
G
II
GG
T
L
T
A
T
L
LAIF
FV
P
LF
F
V
L
V
fig|869729.3.peg.2190
Escherichia coli UM146 (438-1017/1022)
E
I
SG
AL
VAIA
LV
L
S
AVF
L
PM
A
F
F
GG
ST
G
V
IYR
Q
FSIT
IIS
AM
LL
SV
V
VAL
T
LTP
A
LC
G
SV
L
QHVPP-
--
--HKK
GF
FGAFNRF
Y
RRTEDK
Y
QRG
V
I
Y
V
L
RRAART
M
G
L
Y
VVL
G
GGMAL
M
MWK
LP
GS
FLP
TE
D
Q
G
EIMVQY
T
L
P
A
G
A
T
AARTAEVNR
Q
IVDW
F
LINEKAN
T
D
V
I
F
TVD
G
FSFS
---
GSG
QN
TGMAF
V
S
LK
N
WS
Q
-
R
KGAENTAQ
AI
A
L
RA
TKELG
T
I
R
-
-DATVF
A
MTPPA
V
DG
L
G
Q
SNGFTFE
L
L
A
NG
G
AD
R
ET
L
LQMRN
QL
IEK
A
NQS
P
E-
L
HS
V
RA
N
D
L
P
QMPQLQ
V
DID
S
N
KA
V
S
LG
L
S
L
N
D
V
TDT
L
S
S
A
W
G
GTY
V
NDFIDRGRVKK
VY
IQGDSE
F
R
SA
P
S
D
----------
L
GKWF
V
R
G
SD
N
AM
T
PFS
AF
A
TTRWLY
G
P
ER
L
VRY
N
GS
A
AYE
I
QGE
N
A
T
GF
S
S
G
D
A
MTKMEELAN--S
LP
A
G
TTWA
W
S
G
--
LSL
Q
EK
L
---
ASGQALS
L
YAV
S
I
L
V
VFL
C
L
AA
LYES
WSV
P
FS
V
I
L
V
I
P
L
G
L
L
G
A
A
LA
AWMR
D
LN
NDV
YFQV
A
L
L
TT
IGL
S
S
KNAILIV
E
FA
EA-AVA
E
----------
G
YSLS
R
A
A
L
R
A
AQT
R
L
RPI
I
MT
S
LA
F
I
A
G
V
M
PL
AI
A
TGAG
A
N
SRIA
I
G
T
G
II
GG
T
L
T
A
T
L
LAIF
FV
P
Consen1
Primary consensus
VITdASVEvGpalfisl
l
avfiPm
f
gg
Gaiyr
fsiT
Am
svlval
ltP
lca
l
eh
gF
f
Y
v
kiL
l
vy
v
l
lp
FlP
d
G
q
p
g
t
q
y
v
svf
G
---
qn
i
LKp
e
-
R
aii
ra
ki
-
p
I
l
t
l
d
g
h
l
Ql
a
P
l
v
n
le
ididq
kA
alGvsi
Di
l
tA
G
v
vy
yR
pd
----------
i
v
s
g
vpfs
a
gs
l
n
p
I
a
p
s
g
a
Lp
g
w
g
--
Q
L
---
l
s
v
vfl
L
lyes
p
vml
vP
g
vG
lla
g
ndV
G
l
iGl
aknailiv
fa
e
----------
g
eA
l
a
R
RPilMT
la
i
G
lPl
stGaGsg
vg
gvmGGmi
a
vLaif
P
y
LmwlhRHRKSVS
Consen2
Secondary consensus
n
i
ftiislt
i
lslv
t
ed
rlfg
laf
i
aavls
vi
mmg
i
ds
r
-
l
gv
i
a
l
p
g
f
n
s
l
s
s
i
i
rlt
atd
le
v
d
w
kvt
el
g
a
q
s
i
-
a
l
i
i
l
v
a
qd
vnr
s
ry
v
i
in
l
ntentpglaa
k
itla
ap
i
d
s
v
d
m
s
v
k
d
f
ast
ler
m
y
afrr
a
i
s
l
a
i
iwl
n
ls
i
a
kefgv
m
yl
pslnnpqtfse
d
y
g
ka
av
l
m
gn
v
ae
a
pm
lv
s
ly
f
vrrr
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character