┌─ Escherichia coli (4-314/327) APEC O1 (9)  
                                                                     ┌┴─ Escherichia coli (4-314/327) ED1a (2)  
                                                                    ┌┴─ Escherichia coli (4-314/327) 2362-75 (2)  
                                                                   ┌┴┬─ Escherichia coli (4-314/327) F11 (3)  
                                                                  ┌┤ └─ Escherichia coli (4-314/327) H299   
                                                                 ┌┤└─ Escherichia coli (4-314/327) 83972 (5)  
                                                                ┌┤└─ Escherichia coli (4-314/327) O83:H1 str. NRG 857C   
                                                               ┌┤└─ Escherichia coli (4-314/327) NC101   
                                                              ┌┤└─ Escherichia coli (4-314/327) 536 (1)  
                                                             ┌┤└─ Escherichia coli (4-314/327) TA280   
                                                             │└┬─ Escherichia coli (4-314/327) MS 115-1   
                                                            ┌┤ └─ Escherichia coli (4-314/327) B354   
                                                            │└┬─ Escherichia coli (4-314/327) O157:H7 EDL933  [2] 
                                                           ┌┤ └─ Escherichia coli (4-314/327) 1044A (24)  
                                                           │└┬─ Escherichia coli (4-314/327) MS 69-1   
                                                           │ └┬─ Escherichia coli (4-314/327) 042 (6)  
                                                          ┌┤  └─ Escherichia coli (4-314/327) B185   
                                                          ││ ┌─ Escherichia coli (4-314/327) MS 124-1 (1)  
                                                          │└┬┴─ Escherichia coli (4-314/327) B171 (1)  
                                                         ┌┤ └┬─ Escherichia coli (4-314/327) TA271   
                                                         ││  └─ fig|1040638.4.peg.2229 O104:H4 (4-314/327) str. LB226692 (20)  
                                                        ┌┤└┬─ Escherichia coli (4-314/327) 53638 (1)  
                                                        ││ └─ Escherichia coli (4-314/327) K12 (22)  
┌───────────────────────────────────────────────────────┤└─ Escherichia coli (16-326/339) 1827-70 (6)  
│                                                       └─ Escherichia coli (4-314/327) O111:H- str. 11128   
│                                                             ┌─ Escherichia coli (3-331/336) SMS-3-5   
│                                                       ┌─────┴─ Escherichia coli (3-331/336) E24377A (1)  
│┌──────────────────────────────────────────────────────┴── Escherichia coli (3-319/336) M718 (3)  
││                                                                     ┌─ Escherichia coli F11 (2)  
││                                                                    ┌┴─ Escherichia coli 536 (1)  
││                                                                   ┌┴─ Escherichia coli M718   
││                                                                  ┌┴─ Escherichia coli B7A (1)  
││                                                                 ┌┴─ fig|1040638.4.peg.970 O104:H4 str. LB226692 (9)  
││                                                                ┌┴─ Escherichia coli MS 196-1   
││                                                               ┌┴─ Escherichia coli K12 (19)  
││                                                              ┌┴┬─ Escherichia coli MS 145-7   
││                                                              │ └┬─ Escherichia coli APEC O1 (5)  
││                                    ┌─────────────────────────┤  └┬─ Escherichia coli ED1a (2)  
││                                    │                         │   └─ Escherichia coli 83972 (9)  
││             ┌──────────────────────┤                         └─ Escherichia coli MS 124-1 (1)  
││             │                      │           ┌─ Escherichia coli M718   
││             │                      └───────────┤ ┌─ Escherichia coli 042 (53)  
┤│             │                                  │┌┴─ Escherichia coli APEC O1 (6)  
││             │                                  └┤┌─ Escherichia coli 101-1 (7)  
││             │                                   └┤ ┌─ Escherichia coli MS 21-1   
││       ┌─────┤                                    │┌┴─ Escherichia coli MS 185-1   
││       │     │                                    └┤ ┌─ Escherichia coli O157:H7 EDL933 (1)  
││       │     │                                     └┬┴─ Escherichia coli str. K-12 substr. DH10B   
││       │     │                                      └┬─ Escherichia coli 1044A (41)  
││       │     │                                       └─ fig|1040638.4.peg.2021 O104:H4 str. LB226692 (13)  
││       │     │                                       ┌─ Escherichia coli (5-332/342) 83972 (5)  
││       │     └───────────────────────────────────────┤┌─ Escherichia coli (5-325/342) APEC O1 (6)  
││       │                                             └┤┌─ Escherichia coli (5-332/342) ED1a (4)  
││       │                                              └┤┌─ Escherichia coli (5-332/342) M605 (1)  
││       │                                               └┤ ┌─ Escherichia coli (5-332/342) 536 (4)  
││       │                                                │┌┴─ Escherichia coli (5-332/342) E110019 (1)  
││       │                                                └┤┌─ Escherichia coli (5-332/342) 1125A (12)  
││       │                                                 └┤ ┌─ Escherichia coli (5-315/325) FVEC1412 (1)  
││    ┌──┤                                                  └┬┴─ Escherichia coli (5-332/342) B354 (2)  
││    │  │                                                   └┬─ Escherichia coli (5-332/342) M718   
││    │  │                                                    └┬─ fig|1040638.4.peg.3669 O104:H4 (5-332/342) str. LB226692 (53)  
└┤    │  │                                                     └┬─ Escherichia coli (5-332/342) MS 21-1   
 │    │  │                                                      └┬─ Escherichia coli (5-332/342) K12 (20)  
 │    │  │                                                       └┬─ Escherichia coli (5-332/342) MS 115-1   
 │    │  │                                                        └┬─ Escherichia coli (5-332/342) 101-1 (5)  
 │    │  │                                                         └─ Escherichia coli (5-315/325) 1827-70   
 │    │  │                                                           ┌─ Escherichia coli (3-319/334) DH1   
 │    │  │                                                          ┌┴─ Escherichia coli (3-319/334) FVEC1412 (1)  
 │    │  │                                                         ┌┴─ Escherichia coli (3-319/334) K12 (125)  
 │    │  │       ┌─────────────────────────────────────────────────┴─ Escherichia coli (3-319/334) 1125A (1)  
 │    │  │       │                                                ┌─ Escherichia coli (2-315/315) 042 (1)  
 │    │  └───────┤                                               ┌┴─ Escherichia coli (2-315/315) TA143   
 │    │          │                                               │  ┌─ Escherichia coli (2-315/315) 1044A (4)  
 │    │          └───────────────────────────────────────────────┤ ┌┴─ Escherichia coli (2-315/315) O157:H7 EDL933 (1)  
 │    │                                                          │┌┴─ Escherichia coli (2-303/315) 1125A (21)  
 │    │                                                          └┤  ┌─ Escherichia coli (2-315/315) MS 145-7   
 │    │                                                           │ ┌┴─ Escherichia coli (2-315/315) ED1a (1)  
 │    │                                                           └┬┴─ Escherichia coli (2-315/315) 536 (12)  
 │    │                                                            └┬─ fig|1040638.4.peg.942 O104:H4 (2-315/315) str. LB226692 (54)  
 │    │                                                             └┬─ Escherichia coli (2-315/315) B088 (16)  
 │    │                                                              └┬─ Escherichia coli (2-315/315) 101-1 (2)  
 │    │                                                               └┬─ Escherichia coli (2-315/315) TA280   
 │    │                                                                └─ Escherichia coli (2-315/315) K12 (8)  
 │    │                                              ┌─ Escherichia coli (1-326/327) H591 (2)  
 │    │                                             ┌┴─ Escherichia coli (1-326/327) E24377A (7)  
 │    │                                            ┌┴─ Escherichia coli (1-326/327) M605 (1)  
 │    │                                           ┌┴┬─ Escherichia coli (1-326/327) APEC O1 (7)  
 │    │                                          ┌┤ └─ Escherichia coli (1-326/327) B str. REL606 (2)  
 │    │                                          │└┬─ Escherichia coli (4-329/330) K12 (91)  
 │    │                                          │ └┬─ Escherichia coli (4-329/330) ATCC 8739 (1)  
 │    │                         ┌────────────────┤  └┬─ Escherichia coli (1-326/327) 1212A (1)  
 │    │                         │                │   └─ Escherichia coli (1-326/327) B354   
 │    │             ┌───────────┤                └─ Escherichia coli (1-326/327) 2362-75   
 │    │             │           └─────────────────┬─ Escherichia coli (4-321/341) E24377A (1)  
 │    │             │                             └┬─ Escherichia coli (4-321/341) K12 (75)  
 │    │             │                              └┬─ Escherichia coli (4-321/341) 2362-75 (13)  
 └────┤        ┌────┤                               └─ Escherichia coli (4-321/341) ABU 83972 (3)  
      │        │    │                          ┌─ Escherichia coli (1-320/341) MS 115-1   
      │        │    │                          │  ┌─ Escherichia coli (1-320/341) MS 69-1   
      │        │    └──────────────────────────┤ ┌┴─ Escherichia coli (1-320/341) M605   
      │        │                               │┌┴─ Escherichia coli (1-309/330) SE15   
      │        │                               └┤┌─ Escherichia coli (1-320/341) ED1a (1)  
      │        │                                └┤ ┌─ Escherichia coli (14-322/343) 042 (51)  
      │        │                                 │┌┴─ Escherichia coli (1-309/330) H736 (1)  
      │   ┌────┤                                 └┤┌─ Escherichia coli (1-320/341) K12 (61)  
      │   │    │                                  └┤ ┌─ Escherichia coli (1-320/341) 2362-75 (1)  
      │   │    │                                   └┬┴─ Escherichia coli (14-322/343) E2348/69   
      │   │    │                                    └┬─ fig|1040638.4.peg.1350 O104:H4 (1-309/330) str. LB226692 (3)  
      │   │    │                                     └─ Escherichia coli (1-320/341) 55989 (2)  
      │   │    │                                    ┌──────── Escherichia coli (3-324/336) O157:H7 str. EC4024   
      │   │    │                                    │    ┌─ Escherichia coli (3-317/332) 1044A (24)  
      │   │    │                                    │   ┌┴─ Escherichia coli (3-317/332) O55:H7 str. CB9615   
      │   │    └────────────────────────────────────┤   │    ┌─ Escherichia coli (3-317/332) 2362-75 (14)  
      │   │                                         │   │   ┌┴─ Escherichia coli (3-317/332) NC101   
      │   │                                         │   │  ┌┴┬─ Escherichia coli (3-317/332) M605   
      │   │                                         └───┤ ┌┤ └─ Escherichia coli (3-317/332) SE15   
      │   │                                             │ │└─ Escherichia coli (3-317/332) ED1a (2)  
      │   │                                             │┌┤ ┌─ Escherichia coli (3-317/332) SMS-3-5   
      │   │                                             ││└┬┴─ Escherichia coli (3-317/332) MS 21-1   
      │   │                                             └┤ └┬─ Escherichia coli (3-317/332) APEC O1 (6)  
      │   │                                              │  └─ Escherichia coli (3-317/332) WV_060327   
      │   │                                              │┌─ fig|1040638.4.peg.4084 O104:H4 (3-317/332) str. LB226692 (5)  
      │   │                                              └┤ ┌─ Escherichia coli (3-317/332) MS 196-1   
      │   │                                               │┌┴─ Escherichia coli (3-317/332) K12 (25)  
      │   │                                               └┤  ┌─ Escherichia coli (3-317/332) O111:H- str. 11128   
      │   │                                                │ ┌┴─ Escherichia coli (3-317/332) B088 (23)  
      │   │                                                └┬┴─ Escherichia coli (3-317/332) E110019 (1)  
      │   │                                                 └┬─ Escherichia coli (3-317/332) MS 69-1   
      │   │                                                  └┬─ Escherichia coli (3-330/332) M718   
      │   │                                                   └┬─ Escherichia coli (3-317/332) IAI39 (1)  
      │   │                                                    └┬─ Escherichia coli (3-317/332) H299   
      │   │                                                     └─ Escherichia coli (3-317/332) TA280   
      │   │                                                     ┌─ Escherichia coli (13-331/350) 536 (10)  
      │   │                                                    ┌┴─ Escherichia coli (7-318/337) F11   
      │   │                                                   ┌┴─ Escherichia coli (13-331/350) NC101   
      └───┤                                                  ┌┴┬─ Escherichia coli (7-318/337) H299   
          │                                                  │ └┬─ Escherichia coli (13-331/350) HS  [2] 
          │                                                 ┌┤  └─ Escherichia coli (13-331/350) 101-1 (5)  
          │                                                ┌┤└─ fig|1040638.4.peg.2577 O104:H4 (13-331/350) str. LB226692 (6)  
          │                                                │└┬─ Escherichia coli (13-331/350) MS 21-1   
          │                                               ┌┤ └┬─ Escherichia coli (7-318/337) O157:H7 (4)  
          │                                               ││  └─ Escherichia coli (13-331/350) 1044A (20)  
          │                                              ┌┤└─ Escherichia coli (13-331/350) MS 69-1   
          │                                              │└┬─ Escherichia coli (13-331/350) B354   
          │                                             ┌┤ └┬─ Escherichia coli (21-339/358) 042  [2] 
          │                                             ││  └─ Escherichia coli (13-331/350) TA143   
          │                                             │└┬─ Escherichia coli (7-318/337) K12 (8)  
          │                                            ┌┤ └┬─ Escherichia coli (13-331/350) 1827-70 (16)  
          │                                            ││  └┬─ Escherichia coli (13-331/350) O111:H- str. 11128 (1)  
          │                                           ┌┤│   └─ Escherichia coli (13-331/350) B185   
          │                                           ││└─ Escherichia coli (13-331/350) H591 (4)  
          │                                          ┌┤└─ Escherichia coli (7-318/337) B171 (3)  
          │                                          │└┬─ Escherichia coli (13-331/350) O83:H1 str. NRG 857C (1)  
          │                                         ┌┤ └─ Escherichia coli (13-331/350) IAI39 (1)  
          │                                         │└┬─ Escherichia coli (7-318/337) SMS-3-5   
          │             ┌───────────────────────────┤ └─ Escherichia coli (13-331/350) FVEC1302 (3)  
          │             │                           └┬─ Escherichia coli (7-318/337) B088 (5)  
          │             │                            └─ Escherichia coli (13-331/350) B7A (4)  
          │  ┌──────────┤                          ┌─ fig|1040638.4.peg.3225 O104:H4 (4-314/346) str. LB226692 (3)  
          │  │          │                          │  ┌─ Escherichia coli (4-314/346) 101-1   
          │  │          └──────────────────────────┤ ┌┴─ Escherichia coli (4-314/346) O111:H- str. 11128   
          │  │                                     │┌┴─ Escherichia coli (4-314/346) B185   
          │  │                                     └┤ ┌─ Escherichia coli (4-314/346) 1044A (25)  
          │  │                                      └┬┴─ Escherichia coli (6-316/348) 042 (40)  
          │  │                                       └┬─ Escherichia coli (4-314/346) B7A (6)  
          │  │                                        └─ Escherichia coli (4-314/346) K12 (12)  
          └──┤                                                          ┌─ fig|1040638.4.peg.2778 O104:H4 (4-319/331) str. LB226692 (19)  
             │                                                         ┌┴─ Escherichia coli (4-319/331) SE11   
             │                                                        ┌┴┬─ Escherichia coli (2-305/317) O127:H6 str. E2348/69   
             │                                                       ┌┤ └─ Escherichia coli (35-350/362) E2348/69 (2)  
             │                                                      ┌┤└─ Escherichia coli (25-340/352) B354   
             │                                                      │└┬─ Escherichia coli (4-319/331) E24377A (15)  
             │     ┌────────────────────────────────────────────────┤ └─ Escherichia coli (4-319/331) FVEC1412 (3)  
             │     │                                                └─ Escherichia coli (4-319/331) 1125A (27)  
             └─────┤                                     ┌─ Escherichia coli (1-320/356) MS 116-1   
                   │                    ┌────────────────┴─ Escherichia coli (1-320/356) H736   
                   └────────────────────┤                     ┌─ Escherichia coli (2-310/367) O157:H7 str. EC4042   
                                        │                     │┌─ Escherichia coli (2-318/360) 2362-75 (22)  
                                        └─────────────────────┤│┌─ Escherichia coli (1-321/363) E2348/69 (4)  
                                                              │││     ┌─ Escherichia coli (2-318/360) M605   
                                                              └┤│    ┌┴─ Escherichia coli (2-318/360) H299   
                                                               ││   ┌┴─ Escherichia coli (2-318/360) 536 (8)  
                                                               ││  ┌┴─ Escherichia coli (1-321/363) APEC O1   
                                                               └┤ ┌┴┬─── Escherichia coli (2-318/360) CFT073   
                                                                │ │ └┬─ Escherichia coli (2-318/360) 83972 (7)  
                                                                │┌┤  └─ Escherichia coli (2-318/360) TA206   
                                                                ││└─ Escherichia coli (2-318/360) O83:H1 str. NRG 857C   
                                                                ││    ┌─ fig|1040638.4.peg.5358 O104:H4 (2-318/360) str. LB226692 (5)  
                                                                └┤   ┌┴─ Escherichia coli (2-318/360) MS 115-1   
                                                                 │  ┌┴─ Escherichia coli (2-318/360) B088 (6)  
                                                                 │ ┌┴─ Escherichia coli (1-316/320) E22   
                                                                 │┌┴─ Escherichia coli (2-318/360) TA143   
                                                                 └┤┌─ Escherichia coli (1-321/363) 042 (1)  
                                                                  └┤  ┌─ Escherichia coli (2-318/360) MS 21-1   
                                                                   │ ┌┴─ Escherichia coli (2-318/360) SMS-3-5   
                                                                   └┬┴─ Escherichia coli (2-318/360) FVEC1302 (3)  
                                                                    └┬─ Escherichia coli (1-321/363) HS  [2] 
                                                                     └┬─ Escherichia coli (1-321/363) K12 (1)  
                                                                      └┬─ Escherichia coli (1-321/363) E24377A  [2] 
                                                                       └─ Escherichia coli (2-318/360) 1827-70 (29)  
  
Transcriptional repressor of the lac operon (25)
AscBF operon repressor (25)
Evolved beta-D-galactosidase transcriptional repressor (24)
Transcriptional regulator YcjW, LacI family, possibly involved in maltodextrin utilization pathway (21)
Maltose regulon regulatory protein MalI (repressor for malXY) (15)
Trehalose operon transcriptional repressor (12)
Transcriptional (co)regulator CytR (11)
Positive regulator of L-idonate catabolism (11)
Ribose operon repressor (10)
Gluconate utilization system Gnt-I transcriptional repressor (9)
Sucrose specific transcriptional regulator CscR, LacI family (7)
Mgl repressor and galactose ultrainduction factor GalS, HTH-type transcriptional regulator (7)
Fructose repressor FruR, LacI family (4)
Purine nucleotide synthesis repressor (4)
Putative ThuR, regulatory protein for trehalosemaltose transport (3)
hypothetical transcriptional regulator YcjW (1)
Others (11)