┌─ Escherichia coli (80-215/225) K12 (29)  
                          ┌┴─ Escherichia coli (80-215/225) OP50   
               ┌──────────┴┬─ Escherichia coli (80-215/225) 83972 (6)  
┌──────────────┤           └─ Escherichia coli (80-215/225) H299 (17)  
│              └────────────────┬─ Escherichia coli (93-231/238) O157:H7 (25)  
│                               └──┬─ Escherichia coli (138-270/277) O103:H2 str. 12009   
┤                                  └─ Escherichia coli (138-270/277) O55:H7 str. CB9615   
│                                        ┌─────────────────────────── Escherichia coli (76-202/211) 1125A   
│            ┌───────────────────────────┴───────────────────── Escherichia coli (61-201/216) ED1a (1)  
│┌───────────┴──────────────────────────────────────────── Escherichia coli (117-244/249) B171 (3)  
└┤                  ┌─ Escherichia coli IAI1   
 └──────────────────┤  ┌─ fig|1040638.4.peg.1902 O104:H4 str. LB226692 (5)  
                    │ ┌┴─ Escherichia coli EC4100B (7)  
                    └┬┴─ Escherichia coli B088 (5)  
                     └┬─ Escherichia coli E2348/69   
                      └┬─ Escherichia coli 042 (3)  
                       └┬─ Escherichia coli O157:H7 (1)  
                        └─ Escherichia coli MS 69-1   
  

  
Leader peptidase HopD
 (7)
  
Leader peptidase (Prepilin peptidase) (EC 3.4.23.43) / N-methyltransferase (EC 2.1.1.-)
 (7)
  
Bundle-forming prepilin peptidase BfpP
 (1)
  
COG1989: Type II secretory pathway, prepilin signal peptidase PulO and related peptidases
 (1)
  
Type-IV sectretion leader peptidase/N-methyltransferase
 (1)
  
 Others 
(1)