┌─ Escherichia coli (80-215/221) MS 124-1   
                            ├─ Escherichia coli (80-215/225) BW2952   
                            ├─ Escherichia coli (80-215/225) K12   
                            ├─ Escherichia coli (80-215/225) str. K-12 substr. DH10B   
                            ├─ Escherichia coli (80-215/225) str. K-12 substr. MG1655   
                            ├─ Escherichia coli (80-215/225) B str. REL606   
                            ├─ Escherichia coli (DE3 80-215/225) BL21(DE3)   
                            ├─ Escherichia coli (80-215/225) 101-1   
                            ├─ Escherichia coli (80-215/225) 53638   
                            ├─ Escherichia coli (80-215/225) ATCC 8739   
                            ├─ Escherichia coli (80-215/225) H736   
                            ├─ Escherichia coli (80-215/225) HS   
                            ├─ Escherichia coli (80-215/225) MS 116-1   
                            ├─ Escherichia coli (80-215/225) MS 175-1   
                            ├─ Escherichia coli (80-215/225) TA280   
                           ┌┼─ Escherichia coli (26-161/171) 1827-70   
                           │├─ Escherichia coli (80-215/225) MS 196-1   
                           │├─ Escherichia coli (80-215/225) MS 146-1   
                           │├─ Escherichia coli (80-215/225) MS 115-1   
                           │├─ Escherichia coli (80-215/225) HS   
                           │├─ Escherichia coli (80-215/225) ETEC H10407   
                           │├─ Escherichia coli (80-215/225) ATCC 8739   
                           │├─ Escherichia coli (80-215/225) 53638   
                          ┌┤├─ Escherichia coli (80-215/225) MS 187-1   
                          ││├─ Escherichia coli (80-215/225) BL21   
                          ││├─ Escherichia coli (80-215/225) str. K-12 substr. MG1655   
                          ││├─ Escherichia coli (80-215/225) str. K-12 substr. DH10B   
                          ││├─ Escherichia coli (80-215/225) W3110   
                          ││├─ Escherichia coli (80-215/225) DH1   
                          ││└─ Escherichia coli (80-215/221) MS 84-1   
                          │└─ Escherichia coli (80-215/225) OP50   
                          │ ┌─ Escherichia coli (80-215/225) 83972   
               ┌──────────┤ ├─ Escherichia coli (80-215/225) CFT073   
               │          │ ├─ Escherichia coli (80-215/225) MS 185-1   
               │          │┌┼─ Escherichia coli (80-215/225) TA206   
               │          ││├─ Escherichia coli (80-215/225) MS 45-1   
               │          ││├─ Escherichia coli (80-215/225) CFT073   
               │          ││└─ Escherichia coli (80-215/225) ABU 83972   
               │          ││┌─ Escherichia coli (80-215/225) B354   
               │          ││├─ Escherichia coli (80-215/225) 536   
               │          └┤├─ Escherichia coli (80-215/225) F11   
               │           │├─ Escherichia coli (80-215/225) SE15   
               │           │├─ Escherichia coli (80-215/225) NC101   
               │           │├─ Escherichia coli (80-215/225) APEC O1   
               │           │├─ Escherichia coli (80-215/225) O83:H1 str. NRG 857C   
               │           │├─ Escherichia coli (80-215/225) UM146   
               │           └┼─ Escherichia coli (80-215/225) UTI89   
               │            ├─ Escherichia coli (80-215/225) UTI89   
┌──────────────┤            ├─ Escherichia coli (80-215/225) S88   
│              │            ├─ Escherichia coli (80-215/225) IHE3034   
│              │            ├─ Escherichia coli (80-215/225) APEC O1   
│              │            ├─ Escherichia coli (80-215/225) M605   
│              │            ├─ Escherichia coli (80-215/225) MS 200-1   
│              │            ├─ Escherichia coli (80-215/225) F11   
│              │            ├─ Escherichia coli (80-215/225) 536   
│              │            └─ Escherichia coli (80-215/225) H299   
│              │                   ┌─ Escherichia coli (138-270/277) O55:H7 str. CB9615   
│              │                ┌──┴─ Escherichia coli (138-270/277) O103:H2 str. 12009   
│              │                │┌─ Escherichia coli (132-270/277) 1044A   
│              │                │├─ Escherichia coli (132-270/277) 1212A   
│              │                │├─ Escherichia coli (132-270/277) O157:H7 EDL933   
│              │                │├─ Escherichia coli (132-270/277) O157:H7 str. EC4042   
│              │                │├─ Escherichia coli (132-270/277) O157:H7 str. EC4076   
│              └────────────────┤├─ Escherichia coli (132-270/277) O157:H7 str. EC4115   
│                               │├─ Escherichia coli (132-270/277) O157:H7 str. EC4206   
│                               │├─ Escherichia coli (132-270/277) O157:H7 str. EC4486   
│                               │├─ Escherichia coli (132-270/277) O157:H7 str. EC4486   
│                               │├─ Escherichia coli (132-270/277) O157:H7 str. EC508   
│                               │├─ Escherichia coli (132-270/277) O157:H7 str. FRIK2000   
┤                               │├─ Escherichia coli (132-270/277) O157:H7 str. Sakai   
│                               └┼─ Escherichia coli (132-270/277) O157:H7 str. TW14588   
│                                ├─ Escherichia coli (132-270/277) O157:H7 str. TW14359   
│                                ├─ Escherichia coli (132-270/277) O157:H7 str. FRIK966   
│                                ├─ Escherichia coli (132-270/277) O157:H7 str. EC869   
│                                ├─ Escherichia coli (132-270/277) O157:H7 str. EC4501   
│                                ├─ Escherichia coli (132-270/277) O157:H7 str. EC4486   
│                                ├─ Escherichia coli (132-270/277) O157:H7 str. EC4401   
│                                ├─ Escherichia coli (132-270/277) O157:H7 str. EC4196   
│                                ├─ Escherichia coli (132-270/277) O157:H7 str. EC4113   
│                                ├─ Escherichia coli (132-270/277) O157:H7 str. EC4045   
│                                ├─ Escherichia coli (132-270/277) O157:H7 str. EC4024   
│                                ├─ Escherichia coli (132-270/277) 536A   
│                                ├─ Escherichia coli (132-270/277) 1125A   
│                                └─ Escherichia coli (93-231/238) O157:H7   
│                                                        ┌─ Escherichia coli (117-244/249) B171   
│                                                        ├─ Escherichia coli (117-244/249) E2348/69   
│            ┌───────────────────────────────────────────┼─ Escherichia coli (117-244/249) O127:H6 str. E2348/69   
│┌───────────┤                                           └─ Escherichia coli (117-244/249) B171   
││           └───────────────────────────┬─────────────────────────── Escherichia coli (76-202/211) 1125A   
││                                       └────────────────────┬─ Escherichia coli (61-201/216) ED1a   
││                                                            └─ Escherichia coli (61-201/216) ED1a   
└┤                  ┌─ Escherichia coli IAI1   
 │                  │   ┌─ Escherichia coli 042   
 │                  │   ├─ Escherichia coli TA143   
 │                  │  ┌┼─ Escherichia coli UMN026   
 │                  │ ┌┤└─ Escherichia coli MS 198-1   
 └──────────────────┤ │└┬─ Escherichia coli MS 69-1   
                    │┌┤ └┬─ Escherichia coli O157:H7 EDL933   
                    │││  └─ Escherichia coli O157:H7   
                    ││└─ Escherichia coli E2348/69   
                    ││ ┌─ Escherichia coli B088   
                    ││ ├─ Escherichia coli MS 107-1   
                    └┤ ├─ Escherichia coli MS 145-7   
                     │┌┼─ Escherichia coli TA271   
                     ││├─ Escherichia coli MS 119-7   
                     ││└─ Escherichia coli H591   
                     ││ ┌─ fig|1040638.4.peg.1902 O104:H4 str. LB226692   
                     └┤ ├─ Escherichia coli 55989   
                      │ ├─ Escherichia coli E24377A   
                      │┌┼─ Escherichia coli SE11   
                      ││├─ Escherichia coli E24377A   
                      ││└─ fig|6666666.5357.peg.3478 TY-2482 strain   
                      └┤┌─ Escherichia coli KO11   
                       │├─ Escherichia coli MS 78-1   
                       │├─ Escherichia coli O26:H11 str. 11368   
                       └┼─ Escherichia coli W   
                        ├─ Escherichia coli W   
                        ├─ Escherichia coli O111:H- str. 11128   
                        ├─ Escherichia coli MS 182-1   
                        └─ Escherichia coli EC4100B   
  
Leader peptidase HopD (58)
Leader peptidase (Prepilin peptidase) (EC 3.4.23.43) / N-methyltransferase (EC 2.1.1.-) (50)
Bundle-forming prepilin peptidase BfpP (4)
Type 4 prepilin-like proteins leader peptide processing enzyme (EC 3.4.23.43, 2.1.1.-) (2)
Type-IV sectretion leader peptidase/N-methyltransferase (2)
COG1989: Type II secretory pathway, prepilin signal peptidase PulO and related peptidases (1)
COG1989: Type II secretory pathway, prepilin signal peptidase PulO and related peptidases( EC:3.4.23.43 ) (1)
Others (2)