fig|1040638.4.peg.1655
Escherichia coli O104:H4 str. LB226692
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|6666666.5357.peg.3268
Escherichia coli TY-2482
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|585055.6.peg.4064
Escherichia coli 55989
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|585055.8.peg.4067
Escherichia coli 55989
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|550672.3.peg.3636
Escherichia coli B088
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|344601.3.peg.1769
Escherichia coli B171
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|344601.5.peg.1849
Escherichia coli B171
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|340184.3.peg.279
Escherichia coli B7A
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|340184.6.peg.287
Escherichia coli B7A
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|340186.3.peg.1708
Escherichia coli E110019
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|340186.5.peg.1768
Escherichia coli E110019
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|340185.3.peg.19
Escherichia coli E22
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|340185.4.peg.21
Escherichia coli E22
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|562.375.peg.444
Escherichia coli EC4100B
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|656408.3.peg.4017
Escherichia coli H591
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|585034.4.peg.3660
Escherichia coli IAI1
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|585034.5.peg.3657
Escherichia coli IAI1
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|595495.4.peg.4541
Escherichia coli KO11
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|679207.4.peg.208
Escherichia coli MS 107-1
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|749537.3.peg.3911
Escherichia coli MS 115-1
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|679206.4.peg.1795
Escherichia coli MS 119-7
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|679205.4.peg.3108
Escherichia coli MS 124-1
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|679204.3.peg.4635
Escherichia coli MS 145-7
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|749533.3.peg.851
Escherichia coli MS 84-1
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|585395.4.peg.4882
Escherichia coli O103:H2 str. 12009
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|585396.4.peg.4550
Escherichia coli O111:H- str. 11128
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|573235.3.peg.5179
Escherichia coli O26:H11 str. 11368
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|409438.11.peg.4023
Escherichia coli SE11
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|656443.3.peg.4495
Escherichia coli TA271
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|566546.3.peg.4429
Escherichia coli W
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|566546.4.peg.3810
Escherichia coli W
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|550677.3.peg.4146
Escherichia coli B354
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
V
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|585057.4.peg.4231
Escherichia coli IAI39
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
V
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|585057.6.peg.4239
Escherichia coli IAI39
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
V
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|749527.3.peg.2011
Escherichia coli MS 21-1
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
V
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|749531.3.peg.1473
Escherichia coli MS 69-1
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
V
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|439855.10.peg.4040
Escherichia coli SMS-3-5
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
V
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|358709.5.peg.220
Escherichia coli 101-1
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|670888.3.peg.2655
Escherichia coli 1827-70
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|481805.3.peg.147
Escherichia coli ATCC 8739
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|481805.6.peg.148
Escherichia coli ATCC 8739
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|413997.3.peg.3598
Escherichia coli B str. REL606
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|511693.5.peg.3615
Escherichia coli BL21
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|469008.4.peg.165
Escherichia coli BL21(DE3)
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|595496.3.peg.3572
Escherichia coli BW2952
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|536056.3.peg.137
Escherichia coli DH1
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|656414.3.peg.4086
Escherichia coli H736
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|331112.3.peg.3538
Escherichia coli HS
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|331112.6.peg.3691
Escherichia coli HS
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|83333.1.peg.3509
Escherichia coli K12
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|749538.3.peg.3513
Escherichia coli MS 116-1
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|749540.3.peg.2480
Escherichia coli MS 146-1
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|749544.3.peg.3236
Escherichia coli MS 175-1
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|749548.3.peg.96
Escherichia coli MS 196-1
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|316407.3.peg.3553
Escherichia coli W3110
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|316385.5.peg.3704
Escherichia coli str. K-12 substr. DH10B
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|316385.7.peg.3790
Escherichia coli str. K-12 substr. DH10B
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|511145.12.peg.3690
Escherichia coli str. K-12 substr. MG1655
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|511145.6.peg.3672
Escherichia coli str. K-12 substr. MG1655
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|216592.1.peg.853
Escherichia coli 042
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
N
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|216592.3.peg.4032
Escherichia coli 042
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
N
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|331111.12.peg.4312
Escherichia coli E24377A
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
NA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|331111.3.peg.1716
Escherichia coli E24377A
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
NA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|749545.3.peg.3552
Escherichia coli MS 182-1
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
NA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|749532.3.peg.2868
Escherichia coli MS 78-1
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
NA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|656444.3.peg.4888
Escherichia coli TA280
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
N
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|585397.7.peg.4259
Escherichia coli ED1a
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|585397.9.peg.4256
Escherichia coli ED1a
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|685038.3.peg.3637
Escherichia coli O83:H1 str. NRG 857C
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|431946.3.peg.3557
Escherichia coli SE15
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|656440.3.peg.3856
Escherichia coli TA206
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|656393.3.peg.4664
Escherichia coli H299
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
D
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|362663.8.peg.3713
Escherichia coli 536
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SL
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|362663.9.peg.3727
Escherichia coli 536
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SL
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|340197.3.peg.589
Escherichia coli F11
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SL
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|340197.5.peg.608
Escherichia coli F11
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SL
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|749550.3.peg.868
Escherichia coli MS 200-1
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SL
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|216593.1.peg.4316
Escherichia coli E2348/69
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQS
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|574521.7.peg.3914
Escherichia coli O127:H6 str. E2348/69
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQS
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|525281.3.peg.3034
Escherichia coli 83972
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
N
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|655817.3.peg.4199
Escherichia coli ABU 83972
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
N
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|405955.13.peg.4027
Escherichia coli APEC O1
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
N
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|405955.9.peg.3364
Escherichia coli APEC O1
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
N
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|199310.1.peg.4301
Escherichia coli CFT073
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
N
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|199310.4.peg.4129
Escherichia coli CFT073
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
N
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|714962.3.peg.4061
Escherichia coli IHE3034
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
N
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|749546.3.peg.1067
Escherichia coli MS 185-1
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
N
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|749528.3.peg.80
Escherichia coli MS 45-1
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
N
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|585035.6.peg.3922
Escherichia coli S88
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
N
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|869729.3.peg.3870
Escherichia coli UM146
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
N
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|364106.7.peg.4029
Escherichia coli UTI89
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
N
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|364106.8.peg.4030
Escherichia coli UTI89
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
N
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|562.376.peg.2656
Escherichia coli WV_060327
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
N
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|753642.3.peg.4353
Escherichia coli NC101
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
N
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
IRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|656437.3.peg.4030
Escherichia coli TA143
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
D
--
M
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
V
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|656379.3.peg.4909
Escherichia coli FVEC1302
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
D
N
G
DIIP
D
AEA
K
RITTL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
V
S
Q
I
FIA
I
E
VD
K
L
I
DG
A
TRD
A
K
L
-
QRI
M
DY
I
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|656380.3.peg.4697
Escherichia coli FVEC1412
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
D
N
G
DIIP
D
AEA
K
RITTL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
V
S
Q
I
FIA
I
E
VD
K
L
I
DG
A
TRD
A
K
L
-
QRI
M
DY
I
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|749549.3.peg.2684
Escherichia coli MS 198-1
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
D
N
G
DIIP
D
AEA
K
RITTL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
V
S
Q
I
FIA
I
E
VD
K
L
I
DG
A
TRD
A
K
L
-
QRI
M
DY
I
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|585056.7.peg.4262
Escherichia coli UMN026
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
D
N
G
DIIP
D
AEA
K
RITTL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
V
S
Q
I
FIA
I
E
VD
K
L
I
DG
A
TRD
A
K
L
-
QRI
M
DY
I
T
T
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|344610.3.peg.21
Escherichia coli 53638
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
C
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
D
--
M
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|344610.7.peg.2637
Escherichia coli 53638
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
C
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
D
--
M
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
V
I
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
Q
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQA
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
W
A
K
IQAL
fig|670897.3.peg.3757
Escherichia coli 2362-75
MK
VT
F
E
Q
L
K
AA
F
NR
VL
I
S
R
G
V
D
S
E
T
A
DA
C
AE
M
F
AR
T
TES
G
VY
SHG
VN
R
F
P
R
F
I
Q
QL
E
N
G
DIIP
D
AQP
K
RITSL
GA
IEQ
W
DA
Q
R
S
I
G
NLT
AK
KM
M
DR
AIE
L
A
A
D
H
GI
G
L
VAL
R
N
AN
H
W
M
R
G
G
S
Y
GW
QAA
E
K
G
Y
IGI
CWTN
S
IA
---
VM
P
P
W
G
A
K
E
C
R
I
GTNPL
I
VA
I
P
ST--
--
PI
TMV
DM
SM
S
MF
S
Y
G
M
LE
V
N
R
LA
G
RQ
L
P
VDGGF
D
D
E
G
N
L
T
K
E
P
G
II
EKN
--
RR
I
LP
M
G
YW
KG
S
G
M
SI
V
L
DM
I
A
T
L
LS
D
---
G
AS
V
AEV
T
E
D
N
S
DEYG
I
S
Q
I
FIA
I
E
VD
K
L
I
DG
P
TRD
A
K
L
-
QRI
M
DY
V
T
S
AE
R
AD
ENQS
I
R
LPG
HEFTTLL
A
E
NRRN
GI
T
V
DD
SV
fig|362663.8.peg.4313
Escherichia coli 536 (3-333/357)
LQ
I
T
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
A
K
H
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
HP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
fig|362663.9.peg.4329
Escherichia coli 536 (3-333/357)
LQ
I
T
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
A
K
H
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
HP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
fig|340197.3.peg.2064
Escherichia coli F11 (15-345/369)
LQ
I
T
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
A
K
H
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
RP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
fig|340197.5.peg.2176
Escherichia coli F11 (3-333/357)
LQ
I
T
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
A
K
H
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
RP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
fig|749550.3.peg.1449
Escherichia coli MS 200-1 (3-333/357)
LQ
I
T
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
A
K
H
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
RP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
fig|405955.13.peg.4541
Escherichia coli APEC O1 (3-335/357)
LQ
I
A
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
A
K
H
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
RP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
W
I
fig|405955.9.peg.3832
Escherichia coli APEC O1 (15-347/369)
LQ
I
A
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
A
K
H
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
RP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
W
I
fig|714962.3.peg.4579
Escherichia coli IHE3034 (3-335/357)
LQ
I
A
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
A
K
H
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
RP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
W
I
fig|585035.6.peg.4439
Escherichia coli S88 (3-335/357)
LQ
I
A
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
A
K
H
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
RP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
W
I
fig|869729.3.peg.4390
Escherichia coli UM146 (3-335/357)
LQ
I
A
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
A
K
H
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
RP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
W
I
fig|364106.7.peg.4515
Escherichia coli UTI89 (3-335/357)
LQ
I
A
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
A
K
H
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
RP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
W
I
fig|364106.8.peg.4514
Escherichia coli UTI89 (3-335/357)
LQ
I
A
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
A
K
H
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
RP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
W
I
fig|431946.3.peg.4082
Escherichia coli SE15 (3-333/357)
LQ
I
A
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
A
K
H
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
RP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
fig|562.376.peg.1706
Escherichia coli WV_060327 (3-333/357)
LQ
I
A
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
A
K
H
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
RP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
fig|525281.3.peg.1830
Escherichia coli 83972 (3-333/357)
LQ
I
A
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
A
K
R
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
RP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
fig|655817.3.peg.4784
Escherichia coli ABU 83972 (3-333/357)
LQ
I
A
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
A
K
R
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
RP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
fig|199310.1.peg.4934
Escherichia coli CFT073 (15-345/369)
LQ
I
A
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
A
K
R
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
RP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
fig|199310.4.peg.4730
Escherichia coli CFT073 (3-333/357)
LQ
I
A
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
A
K
R
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
RP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
fig|749546.3.peg.1024
Escherichia coli MS 185-1 (3-333/357)
LQ
I
A
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
A
K
R
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
RP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
fig|749528.3.peg.4442
Escherichia coli MS 45-1 (3-333/357)
LQ
I
A
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
A
K
R
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
RP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
fig|670897.3.peg.1357
Escherichia coli 2362-75 (3-333/357)
LQ
I
A
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
T
K
H
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
RP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
fig|216593.1.peg.3963
Escherichia coli E2348/69 (15-345/369)
LQ
I
A
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
T
K
H
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
RP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
fig|656417.3.peg.5126
Escherichia coli M605 (3-333/357)
LQ
I
A
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
T
K
H
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
RP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
fig|753642.3.peg.4102
Escherichia coli NC101 (3-333/357)
LQ
I
A
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
T
K
H
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
RP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
fig|574521.7.peg.4475
Escherichia coli O127:H6 str. E2348/69 (3-333/357)
LQ
I
A
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
T
K
H
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
RP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
fig|685038.3.peg.4140
Escherichia coli O83:H1 str. NRG 857C (3-333/357)
LQ
I
A
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
T
K
H
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
RP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
fig|656440.3.peg.4620
Escherichia coli TA206 (3-333/357)
LQ
I
A
V
E
K
V
R
WL
A
AG
L
L
E
L
N
G
C
D
A
D
I
A
QD
VAE
H
M
IE
A
ERY
G
FA
SHG
VT
L
L
P
K
Y
L
E
NI
A
R
G
DVTA
N
ARP
E
CLTSE
G
N
LQR
F
H
A
H
N
G
F
GQ
H
A
G
K
VA
V
NA
AIE
Q
T
K
H
R
G
FC
L
L
T
L
C
H
AH
H
L
GR
M
G
HY
GQ
MV
A
D
Q
G
L
AM
L
AMSN
V
TG
R
P
A
L
V
A
P
W
GG
A
E
P
R
M
T
TNP
F
C
F
A
W
P
FSDG
RP
PI
-LV
D
F
ATS
SM
A
LN
K
AR
V
MS
ST
G
KQ
AA
PGQLI
D
A
Q
G
N
P
S
N
DP
G
V
L
FSN
P
P
GA
LLP
F
G
EH
KG
F
GL
AL
M
I
E
M
M
A
G
I
LSG
---
G
DT
I
AED
H
-
Q
T
D
GSA-
H
N
H
L
FAL
I
I
D
P
D
Q
F
--
T
DLA
G
E
K
G
QFF
A
DY
L
L
A
TQ
P
Q
P
GGNP
V
I
Y
PG
MPEA-AN
RE
RNAK
M
I
T
I
PV
SF
W
S
fig|656393.3.peg.1555
Escherichia coli H299 (10-338/361)
Q
R
LH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
VVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
R
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
EDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|358709.5.peg.3079
Escherichia coli 101-1 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|670888.3.peg.1361
Escherichia coli 1827-70 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|344610.3.peg.3235
Escherichia coli 53638 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|344610.7.peg.886
Escherichia coli 53638 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|481805.3.peg.3054
Escherichia coli ATCC 8739 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|481805.6.peg.3040
Escherichia coli ATCC 8739 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|413997.3.peg.811
Escherichia coli B str. REL606 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|511693.5.peg.839
Escherichia coli BL21 (10-338/399)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|469008.4.peg.2922
Escherichia coli BL21(DE3) (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|595496.3.peg.724
Escherichia coli BW2952 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|536056.3.peg.2998
Escherichia coli DH1 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|562.375.peg.4392
Escherichia coli EC4100B (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|316401.4.peg.1007
Escherichia coli ETEC H10407 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|331112.3.peg.792
Escherichia coli HS (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|331112.6.peg.826
Escherichia coli HS (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|83333.1.peg.787
Escherichia coli K12 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|749537.3.peg.3546
Escherichia coli MS 115-1 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
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LD
G
DRA
F
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H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
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IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
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N
P
A
VM
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PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
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AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|749538.3.peg.731
Escherichia coli MS 116-1 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
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IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
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GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|679205.4.peg.2071
Escherichia coli MS 124-1 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|749540.3.peg.2737
Escherichia coli MS 146-1 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
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IG
M
I
P
S
Y
V
R
SW
S
Q
G
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N
HHA
K
TVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
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GA
P
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AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|749544.3.peg.2685
Escherichia coli MS 175-1 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
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N
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K
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GA
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LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
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L
N
C
M
TTI
I
I
NP
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P
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AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
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I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|749547.3.peg.1651
Escherichia coli MS 187-1 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
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N
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K
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GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
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AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|749533.3.peg.4812
Escherichia coli MS 84-1 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
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IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
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AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|409438.11.peg.983
Escherichia coli SE11 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|316407.3.peg.768
Escherichia coli W3110 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|316385.5.peg.865
Escherichia coli str. K-12 substr. DH10B (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|316385.7.peg.877
Escherichia coli str. K-12 substr. DH10B (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|511145.12.peg.828
Escherichia coli str. K-12 substr. MG1655 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
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TR
VA
W
HK
G
VP
VP
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D
V
NG
V
PTT
N
P
A
VM
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PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
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---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
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E
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P
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AQ
T
-
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A
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V
K
A
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P
H
D
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RE
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GI
P
L
D
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GS
W
Q
AI
fig|511145.6.peg.820
Escherichia coli str. K-12 substr. MG1655 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
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D
H
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Q
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H
N
SH
H
I
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Q
C
A
A
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VS
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IP
-
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-
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L
-LL
D
Y
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AI
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TR
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W
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G
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VP
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D
V
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N
P
A
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PL
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T
F
A
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A
L
AA
M
C
E
I
L
G
G
A
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---
G
KT
T
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T
L
Q
T
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L
N
C
M
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I
I
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P
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AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
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I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|525281.3.peg.2152
Escherichia coli 83972 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
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M
I
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N
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LD
G
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H
EA
M
AL
G
IE
K
A
R
Q
H
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A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
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D
V
NG
V
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N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
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---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
EDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|655817.3.peg.886
Escherichia coli ABU 83972 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
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G
HD
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IG
M
I
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S
Y
V
R
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S
Q
G
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N
HHA
K
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GA
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LD
G
DRA
F
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H
EA
M
AL
G
IE
K
A
R
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
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F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
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D
V
NG
V
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N
P
A
VM
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PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
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---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
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P
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AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
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I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|199310.1.peg.858
Escherichia coli CFT073 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
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G
HD
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IG
M
I
P
S
Y
V
R
SW
S
Q
G
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N
HHA
K
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AVT
LD
G
DRA
F
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H
EA
M
AL
G
IE
K
A
R
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
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N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
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AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
EDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|199310.4.peg.840
Escherichia coli CFT073 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
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N
HHA
K
VVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
R
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
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---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
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I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|749546.3.peg.4962
Escherichia coli MS 185-1 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
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IG
M
I
P
S
Y
V
R
SW
S
Q
G
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N
HHA
K
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GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
R
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
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---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
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AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
EDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|749528.3.peg.4539
Escherichia coli MS 45-1 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
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IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
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GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
R
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
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---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
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AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
EDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|679207.4.peg.1459
Escherichia coli MS 107-1 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
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IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKES
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GA
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|550672.3.peg.1039
Escherichia coli B088 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|595495.4.peg.3222
Escherichia coli KO11 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|566546.3.peg.3764
Escherichia coli W (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|566546.4.peg.850
Escherichia coli W (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
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---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
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AQ
T
-
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A
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V
K
A
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D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|331111.12.peg.1160
Escherichia coli E24377A (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKES
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
K
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GA
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|331111.3.peg.3369
Escherichia coli E24377A (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKES
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
K
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GA
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|679204.3.peg.5221
Escherichia coli MS 145-7 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKES
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
K
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GA
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|585396.4.peg.896
Escherichia coli O111:H- str. 11128 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKES
GA
AVT
LD
G
DRA
F
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H
EA
M
AL
G
IE
K
A
H
K
H
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A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
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IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
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F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GA
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|573235.3.peg.940
Escherichia coli O26:H11 str. 11368 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
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GA
AVT
LD
G
DRA
F
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H
EA
M
AL
G
IE
K
A
H
K
H
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A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
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F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
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PL
GA
LL
T
F
A
EH
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A
L
AA
M
C
E
I
L
G
G
A
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---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|585397.7.peg.774
Escherichia coli ED1a (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
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GA
AVT
LD
G
DRA
F
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H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
EDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|585397.9.peg.774
Escherichia coli ED1a (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
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GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
EDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|753642.3.peg.864
Escherichia coli NC101 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
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GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
EDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|585057.4.peg.824
Escherichia coli IAI39 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDK
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
LGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|585057.6.peg.821
Escherichia coli IAI39 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDK
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
LGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|340186.3.peg.2585
Escherichia coli E110019 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GA
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|340186.5.peg.2672
Escherichia coli E110019 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GA
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|749545.3.peg.996
Escherichia coli MS 182-1 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GA
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|749532.3.peg.2673
Escherichia coli MS 78-1 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GA
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|216592.1.peg.3327
Escherichia coli 042 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLRI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKS
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|216592.3.peg.918
Escherichia coli 042 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLRI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKS
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|749531.3.peg.1753
Escherichia coli MS 69-1 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDD
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|749548.3.peg.2307
Escherichia coli MS 196-1 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
V
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|656444.3.peg.1352
Escherichia coli TA280 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDD
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
A
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|340184.3.peg.1197
Escherichia coli B7A (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKES
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
K
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
S
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GA
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|340184.6.peg.1260
Escherichia coli B7A (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKES
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
K
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
S
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GA
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|405955.13.peg.760
Escherichia coli APEC O1 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
VVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
R
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|405955.9.peg.637
Escherichia coli APEC O1 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
VVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
R
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|714962.3.peg.808
Escherichia coli IHE3034 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
VVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
R
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|585035.6.peg.820
Escherichia coli S88 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
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AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
R
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|562.376.peg.4804
Escherichia coli WV_060327 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
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AVT
LD
G
DRA
F
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H
EA
M
AL
G
IE
K
A
R
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|362663.8.peg.822
Escherichia coli 536 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
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GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|362663.9.peg.822
Escherichia coli 536 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
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GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|656417.3.peg.987
Escherichia coli M605 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
VVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|749550.3.peg.3768
Escherichia coli MS 200-1 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
VVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|431946.3.peg.762
Escherichia coli SE15 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
VVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|155864.1.peg.873
Escherichia coli O157:H7 EDL933 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDD
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EXF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|155864.8.peg.899
Escherichia coli O157:H7 EDL933 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDD
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EXF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|1040638.4.peg.4910
Escherichia coli O104:H4 str. LB226692 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|6666666.5357.peg.4928
Escherichia coli TY-2482 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|562.371.peg.2251
Escherichia coli 1044A (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDD
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|562.373.peg.1234
Escherichia coli 1125A (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDD
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|562.372.peg.1099
Escherichia coli 1212A (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDD
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|562.374.peg.2633
Escherichia coli 536A (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDD
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|344601.3.peg.2539
Escherichia coli B171 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|344601.5.peg.2642
Escherichia coli B171 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|550676.3.peg.263
Escherichia coli B185 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|340185.3.peg.2856
Escherichia coli E22 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|340185.4.peg.3008
Escherichia coli E22 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|656408.3.peg.803
Escherichia coli H591 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|656419.3.peg.1084
Escherichia coli M718 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDD
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|679206.4.peg.4018
Escherichia coli MS 119-7 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|585395.4.peg.883
Escherichia coli O103:H2 str. 12009 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
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PL
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LL
T
F
A
EH
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L
AA
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I
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---
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KT
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L
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T
-
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H
D
DDKP
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L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
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W
Q
AI
fig|83334.1.peg.949
Escherichia coli O157:H7 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
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H
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H
N
SH
H
I
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Q
C
A
A
AG
F
VS
I
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IP
-
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PF
H
G
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V
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F
-
P
L
-LL
D
Y
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AI
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TR
VA
W
HK
G
VP
VP
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D
V
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V
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N
P
A
VM
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PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
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---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
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P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|444454.5.peg.5370
Escherichia coli O157:H7 str. EC4024 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
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M
I
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Y
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R
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S
Q
G
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N
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G
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EA
M
AL
G
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A
H
Q
H
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A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
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IP
-
MV
A
PF
H
G
R
D
S
R
F
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C
V
V
F
P
RKDD
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
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D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
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---
G
KT
T
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T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
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P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|444449.5.peg.4304
Escherichia coli O157:H7 str. EC4042 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
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G
HD
SHG
IG
M
I
P
S
Y
V
R
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S
Q
G
HLQI
N
HHA
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LD
G
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F
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H
EA
M
AL
G
IE
K
A
H
Q
H
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A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
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IP
-
MV
A
PF
H
G
R
D
S
R
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C
V
V
F
P
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F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
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D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
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---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
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GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|444448.5.peg.3580
Escherichia coli O157:H7 str. EC4045 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
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GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
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IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDD
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
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D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
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---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
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GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|444453.5.peg.922
Escherichia coli O157:H7 str. EC4076 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
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GA
AVT
LD
G
DRA
F
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H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
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IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
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F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
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LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|444452.5.peg.4902
Escherichia coli O157:H7 str. EC4113 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
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IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
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GA
AVT
LD
G
DRA
F
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H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
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IP
-
MV
A
PF
H
G
R
D
S
R
F
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C
V
V
F
P
RKDD
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
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D
V
NG
V
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N
P
A
VM
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PL
GS
LL
T
F
A
EH
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A
L
AA
M
C
E
I
L
G
G
A
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---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
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I
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P
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AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|444450.8.peg.1037
Escherichia coli O157:H7 str. EC4115 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
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GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
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IP
-
MV
A
PF
H
G
R
D
S
R
F
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C
V
V
F
P
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F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
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---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
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GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|444451.5.peg.4685
Escherichia coli O157:H7 str. EC4196 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
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GA
AVT
LD
G
DRA
F
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H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
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IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDD
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
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---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|444447.5.peg.3772
Escherichia coli O157:H7 str. EC4206 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDD
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|478004.5.peg.3299
Escherichia coli O157:H7 str. EC4401 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDD
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|478005.5.peg.1421
Escherichia coli O157:H7 str. EC4486 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDD
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|478006.5.peg.4611
Escherichia coli O157:H7 str. EC4501 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDD
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
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D
V
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V
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N
P
A
VM
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PL
GS
LL
T
F
A
EH
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A
L
AA
M
C
E
I
L
G
G
A
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---
G
KT
T
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T
L
Q
T
S
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L
N
C
M
TTI
I
I
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E
LF
GA
P
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AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|478007.5.peg.2633
Escherichia coli O157:H7 str. EC508 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
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AL
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A
H
Q
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VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
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IP
-
MV
A
PF
H
G
R
D
S
R
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V
V
F
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F
-
P
L
-LL
D
Y
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AI
AFGK
TR
VA
W
HK
G
VP
VP
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D
V
NG
V
PTT
N
P
A
VM
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PL
GS
LL
T
F
A
EH
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A
L
AA
M
C
E
I
L
G
G
A
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---
G
KT
T
HQE
T
L
Q
T
S
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L
N
C
M
TTI
I
I
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P
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AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|478008.5.peg.2271
Escherichia coli O157:H7 str. EC869 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
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M
I
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S
Y
V
R
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Q
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G
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H
EA
M
AL
G
IE
K
A
H
Q
H
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A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
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IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
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F
-
P
L
-LL
D
Y
ATS
AI
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TR
VA
W
HK
G
VP
VP
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D
V
NG
V
PTT
N
P
A
VM
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PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
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---
G
KT
T
HQE
T
L
Q
T
S
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L
N
C
M
TTI
I
I
NP
E
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GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|637388.3.peg.2571
Escherichia coli O157:H7 str. FRIK2000 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
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IG
M
I
P
S
Y
V
R
SW
S
Q
G
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N
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K
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LD
G
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F
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H
EA
M
AL
G
IE
K
A
H
Q
H
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A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
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IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
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F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
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N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
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---
G
KT
T
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T
L
Q
T
S
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L
N
C
M
TTI
I
I
NP
E
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GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|570506.3.peg.4458
Escherichia coli O157:H7 str. FRIK966 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
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G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
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K
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LD
G
DRA
F
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H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
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IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDD
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
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PL
GS
LL
T
F
A
EH
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A
L
AA
M
C
E
I
L
G
G
A
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---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
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LF
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P
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AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|386585.9.peg.993
Escherichia coli O157:H7 str. Sakai (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
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G
HD
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IG
M
I
P
S
Y
V
R
SW
S
Q
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K
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G
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H
EA
M
AL
G
IE
K
A
H
Q
H
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A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
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V
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IP
-
MV
A
PF
H
G
R
D
S
R
F
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F
C
V
V
F
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F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
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D
V
NG
V
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P
A
VM
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PL
GS
LL
T
F
A
EH
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A
L
AA
M
C
E
I
L
G
G
A
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---
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KT
T
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T
L
Q
T
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L
N
C
M
TTI
I
I
NP
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GA
P
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AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
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I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|544404.4.peg.903
Escherichia coli O157:H7 str. TW14359 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
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G
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IG
M
I
P
S
Y
V
R
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S
Q
G
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K
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G
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F
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EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
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V
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IP
-
MV
A
PF
H
G
R
D
S
R
F
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V
V
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F
-
P
L
-LL
D
Y
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AI
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TR
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W
HK
G
VP
VP
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D
V
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P
A
VM
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T
F
A
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L
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C
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I
L
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---
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T
L
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T
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N
C
M
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AQ
T
-
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A
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V
K
A
S-
P
H
D
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I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|502346.5.peg.312
Escherichia coli O157:H7 str. TW14588 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
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G
HD
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IG
M
I
P
S
Y
V
R
SW
S
Q
G
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K
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GA
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G
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F
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H
EA
M
AL
G
IE
K
A
H
Q
H
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A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
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IP
-
MV
A
PF
H
G
R
D
S
R
F
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C
V
V
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P
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F
-
P
L
-LL
D
Y
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AI
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TR
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W
HK
G
VP
VP
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D
V
NG
V
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N
P
A
VM
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PL
GS
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T
F
A
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A
L
AA
M
C
E
I
L
G
G
A
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---
G
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T
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T
L
Q
T
S
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L
N
C
M
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I
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P
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AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|701177.3.peg.1011
Escherichia coli O55:H7 str. CB9615 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
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IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
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GA
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LD
G
DRA
F
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H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
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V
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IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
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F
-
P
L
-LL
D
Y
ATS
AI
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TR
VA
W
HK
G
VP
VP
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D
V
NG
V
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N
P
A
VM
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PL
GS
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T
F
A
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A
L
AA
M
C
E
I
L
G
G
A
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---
G
KT
T
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T
L
Q
T
S
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L
N
C
M
TTI
I
I
NP
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GA
P
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AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|656440.3.peg.656
Escherichia coli TA206 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
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G
HD
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IG
M
I
P
S
Y
V
R
SW
S
Q
G
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N
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K
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GA
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LD
G
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F
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H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
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IP
-
MV
A
PF
H
G
R
D
S
R
F
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F
C
V
V
F
P
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F
-
P
L
-LL
D
Y
ATS
AI
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TR
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W
HK
G
VP
VP
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D
V
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V
PTT
N
P
A
VM
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PL
GS
LL
T
F
A
EH
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A
L
AA
M
C
E
I
L
G
G
A
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---
G
KT
T
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T
L
Q
T
S
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L
N
C
M
TTI
I
I
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E
LF
GA
P
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AQ
T
-
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A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|656443.3.peg.1074
Escherichia coli TA271 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
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G
HD
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IG
M
I
P
S
Y
V
R
SW
S
Q
G
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N
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K
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GA
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G
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F
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H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
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V
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IP
-
MV
A
PF
H
G
R
D
S
R
F
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F
C
V
V
F
P
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F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
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W
HK
G
VP
VP
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D
V
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V
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N
P
A
VM
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PL
GS
LL
T
F
A
EH
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A
L
AA
M
C
E
I
L
G
G
A
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---
G
KT
T
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T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
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E
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GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|585055.6.peg.855
Escherichia coli 55989 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
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N
HHA
K
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GA
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LD
G
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F
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H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
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IP
-
MV
A
PF
H
G
R
D
S
R
F
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F
C
V
V
F
P
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F
-
P
L
-LL
D
Y
ATS
AI
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TR
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W
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G
VP
VP
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D
V
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V
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N
P
A
VM
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PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
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---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTH
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|585055.8.peg.859
Escherichia coli 55989 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
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GA
AVT
LD
G
DRA
F
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H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTH
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|439855.10.peg.982
Escherichia coli SMS-3-5 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
VVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
I
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|656379.3.peg.1637
Escherichia coli FVEC1302 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLRI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
IP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
L
E
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|656380.3.peg.1465
Escherichia coli FVEC1412 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLRI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
IP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
L
E
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|585056.7.peg.1140
Escherichia coli UMN026 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLRI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
IP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
L
E
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|585034.4.peg.825
Escherichia coli IAI1 (10-337/360)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKES
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
-DKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|585034.5.peg.821
Escherichia coli IAI1 (10-337/360)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
TVKES
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCN
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
-DKP
I
L
LPG
EWEVNTR
RE
RQKQ
GI
P
L
D
A
GS
W
Q
AI
fig|869729.3.peg.2912
Escherichia coli UM146 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
VVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
R
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
N
L
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|364106.7.peg.889
Escherichia coli UTI89 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
VVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
R
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
N
L
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|364106.8.peg.888
Escherichia coli UTI89 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
VVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
R
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
N
L
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|550677.3.peg.2070
Escherichia coli B354 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
VVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
V
L
PGCLI
D
V
NG
M
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQK
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|670897.3.peg.4829
Escherichia coli 2362-75 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
VVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
R
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|216593.1.peg.1396
Escherichia coli E2348/69 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
VVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
R
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|574521.7.peg.775
Escherichia coli O127:H6 str. E2348/69 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
VVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
R
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|685038.3.peg.727
Escherichia coli O83:H1 str. NRG 857C (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
VVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
R
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEL
GI
P
L
D
A
GS
W
Q
AI
fig|749527.3.peg.4371
Escherichia coli MS 21-1 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLQI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDK
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
VP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
VM
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
F
SG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
RE
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|749549.3.peg.2317
Escherichia coli MS 198-1 (10-338/361)
Q
TLH
SF
I
QA
V
F
R
Q
M
G
S
E
E
Q
E
A
KL
VA
D
H
L
IA
A
NLA
G
HD
SHG
IG
M
I
P
S
Y
V
R
SW
S
Q
G
HLRI
N
HHA
K
IVKEA
GA
AVT
LD
G
DRA
F
GQVAA
H
EA
M
AL
G
IE
K
A
H
Q
H
GIA
A
VAL
H
N
SH
H
I
GRIGYW
AE
Q
C
A
A
AG
F
VS
I
HFVS
V
VG
IP
-
MV
A
PF
H
G
R
D
S
R
F
GTNP
F
C
V
V
F
P
RKDN
F
-
P
L
-LL
D
Y
ATS
AI
AFGK
TR
VA
W
HK
G
IP
VP
PGCLI
D
V
NG
V
PTT
N
P
A
G
M
QES
PL
GS
LL
T
F
A
EH
KGY
A
L
AA
M
C
E
I
L
G
G
A
LSG
---
G
KT
T
HQE
T
L
Q
T
S
PDAI
L
N
C
M
TTI
I
I
NP
E
LF
GA
P
DCS
AQ
T
-
EAF
A
EW
V
K
A
S-
P
H
D
DDKP
I
L
LPG
EWEVNTR
L
E
RQEQ
GI
P
L
D
A
GS
W
Q
AI
fig|344601.3.peg.3918
Escherichia coli B171 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
F
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|344601.5.peg.4110
Escherichia coli B171 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
F
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|340184.3.peg.3217
Escherichia coli B7A (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
F
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|340184.6.peg.3357
Escherichia coli B7A (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
F
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|340185.3.peg.2499
Escherichia coli E22 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
F
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|340185.4.peg.2638
Escherichia coli E22 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
F
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|679204.3.peg.4289
Escherichia coli MS 145-7 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
F
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|585395.4.peg.516
Escherichia coli O103:H2 str. 12009 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
F
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|585034.4.peg.517
Escherichia coli IAI1 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
F
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
L
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|585034.5.peg.516
Escherichia coli IAI1 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
F
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
L
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|670897.3.peg.200
Escherichia coli 2362-75 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|362663.8.peg.579
Escherichia coli 536 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|362663.9.peg.580
Escherichia coli 536 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|525281.3.peg.2392
Escherichia coli 83972 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|655817.3.peg.637
Escherichia coli ABU 83972 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|405955.13.peg.522
Escherichia coli APEC O1 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|405955.9.peg.430
Escherichia coli APEC O1 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|199310.1.peg.608
Escherichia coli CFT073 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|199310.4.peg.597
Escherichia coli CFT073 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|216593.1.peg.3073
Escherichia coli E2348/69 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|585397.7.peg.537
Escherichia coli ED1a (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|585397.9.peg.539
Escherichia coli ED1a (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|340197.3.peg.2386
Escherichia coli F11 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|340197.5.peg.2501
Escherichia coli F11 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|714962.3.peg.513
Escherichia coli IHE3034 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|656417.3.peg.664
Escherichia coli M605 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|749546.3.peg.3630
Escherichia coli MS 185-1 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|749550.3.peg.4657
Escherichia coli MS 200-1 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|749528.3.peg.3540
Escherichia coli MS 45-1 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|753642.3.peg.1112
Escherichia coli NC101 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|574521.7.peg.482
Escherichia coli O127:H6 str. E2348/69 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|685038.3.peg.490
Escherichia coli O83:H1 str. NRG 857C (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|585035.6.peg.515
Escherichia coli S88 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|431946.3.peg.495
Escherichia coli SE15 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|656440.3.peg.398
Escherichia coli TA206 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|869729.3.peg.3161
Escherichia coli UM146 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|364106.7.peg.653
Escherichia coli UTI89 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|364106.8.peg.651
Escherichia coli UTI89 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|562.376.peg.631
Escherichia coli WV_060327 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
T
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|656379.3.peg.1011
Escherichia coli FVEC1302 (1-328/349)
MKIS
R
ETL
R
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
NA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|656380.3.peg.769
Escherichia coli FVEC1412 (1-328/349)
MKIS
R
ETL
R
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
NA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|749549.3.peg.1424
Escherichia coli MS 198-1 (1-328/349)
MKIS
R
ETL
R
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
NA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|585056.7.peg.765
Escherichia coli UMN026 (1-328/349)
MKIS
R
ETL
R
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
NA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|344610.3.peg.1522
Escherichia coli 53638 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
F
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
V
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|344610.7.peg.1157
Escherichia coli 53638 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
F
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
V
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|595496.3.peg.439
Escherichia coli BW2952 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
F
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
V
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|536056.3.peg.3271
Escherichia coli DH1 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
F
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
V
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|656414.3.peg.718
Escherichia coli H736 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
F
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
V
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|83333.1.peg.513
Escherichia coli K12 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
F
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
V
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|749538.3.peg.2568
Escherichia coli MS 116-1 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
F
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
V
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|749540.3.peg.4810
Escherichia coli MS 146-1 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
F
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
V
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|749544.3.peg.262
Escherichia coli MS 175-1 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
F
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
V
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|749548.3.peg.1736
Escherichia coli MS 196-1 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
F
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
V
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|316407.3.peg.501
Escherichia coli W3110 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
F
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
V
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|316385.5.peg.472
Escherichia coli str. K-12 substr. DH10B (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
F
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
V
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|316385.7.peg.479
Escherichia coli str. K-12 substr. DH10B (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
F
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
V
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|511145.12.peg.537
Escherichia coli str. K-12 substr. MG1655 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
F
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
V
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|511145.6.peg.531
Escherichia coli str. K-12 substr. MG1655 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
F
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
V
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|340186.3.peg.825
Escherichia coli E110019 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
FS
S
KLF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|340186.5.peg.860
Escherichia coli E110019 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
FS
S
KLF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|331111.12.peg.861
Escherichia coli E24377A (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
FS
S
KLF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|331111.3.peg.3088
Escherichia coli E24377A (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
FS
S
KLF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|562.375.peg.3966
Escherichia coli EC4100B (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
FS
S
KLF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|656408.3.peg.462
Escherichia coli H591 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
FS
S
KLF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|679206.4.peg.29
Escherichia coli MS 119-7 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
FS
S
KLF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|585396.4.peg.569
Escherichia coli O111:H- str. 11128 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
FS
S
KLF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|573235.3.peg.559
Escherichia coli O26:H11 str. 11368 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
FS
S
KLF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|409438.11.peg.670
Escherichia coli SE11 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
FS
S
KLF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|656443.3.peg.776
Escherichia coli TA271 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
FS
S
KLF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|358709.5.peg.2034
Escherichia coli 101-1 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
LQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
FS
S
KLF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|413997.3.peg.499
Escherichia coli B str. REL606 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
LQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
FS
S
KLF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|511693.5.peg.505
Escherichia coli BL21 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
LQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
FS
S
KLF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|469008.4.peg.3246
Escherichia coli BL21(DE3) (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
LQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
FS
S
KLF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|749547.3.peg.1404
Escherichia coli MS 187-1 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
LQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
FS
S
KLF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|749537.3.peg.2758
Escherichia coli MS 115-1 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
F
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
V
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HID
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|656444.3.peg.1014
Escherichia coli TA280 (1-328/349)
MK
V
S
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
NA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|749527.3.peg.4976
Escherichia coli MS 21-1 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SLCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
T
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|679207.4.peg.4479
Escherichia coli MS 107-1 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|749545.3.peg.3657
Escherichia coli MS 182-1 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|749532.3.peg.2544
Escherichia coli MS 78-1 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|439855.10.peg.733
Escherichia coli SMS-3-5 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|550677.3.peg.962
Escherichia coli B354 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
NA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|316401.4.peg.654
Escherichia coli ETEC H10407 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
NA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|656437.3.peg.613
Escherichia coli TA143 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
NA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|562.371.peg.2787
Escherichia coli 1044A (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
Q
AAVE
GI
E
I
V
D
DI
Y
fig|562.373.peg.3206
Escherichia coli 1125A (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
Q
AAVE
GI
E
I
V
D
DI
Y
fig|562.372.peg.1519
Escherichia coli 1212A (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
Q
AAVE
GI
E
I
V
D
DI
Y
fig|562.374.peg.5457
Escherichia coli 536A (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
Q
AAVE
GI
E
I
V
D
DI
Y
fig|83334.1.peg.651
Escherichia coli O157:H7 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
Q
AAVE
GI
E
I
V
D
DI
Y
fig|155864.1.peg.574
Escherichia coli O157:H7 EDL933 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
Q
AAVE
GI
E
I
V
D
DI
Y
fig|155864.8.peg.588
Escherichia coli O157:H7 EDL933 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
Q
AAVE
GI
E
I
V
D
DI
Y
fig|444454.5.peg.5063
Escherichia coli O157:H7 str. EC4024 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
Q
AAVE
GI
E
I
V
D
DI
Y
fig|444449.5.peg.5398
Escherichia coli O157:H7 str. EC4042 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
Q
AAVE
GI
E
I
V
D
DI
Y
fig|444448.5.peg.3274
Escherichia coli O157:H7 str. EC4045 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
Q
AAVE
GI
E
I
V
D
DI
Y
fig|444453.5.peg.615
Escherichia coli O157:H7 str. EC4076 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
Q
AAVE
GI
E
I
V
D
DI
Y
fig|444452.5.peg.912
Escherichia coli O157:H7 str. EC4113 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
Q
AAVE
GI
E
I
V
D
DI
Y
fig|444450.8.peg.734
Escherichia coli O157:H7 str. EC4115 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
Q
AAVE
GI
E
I
V
D
DI
Y
fig|444451.5.peg.2235
Escherichia coli O157:H7 str. EC4196 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
Q
AAVE
GI
E
I
V
D
DI
Y
fig|444447.5.peg.3448
Escherichia coli O157:H7 str. EC4206 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
Q
AAVE
GI
E
I
V
D
DI
Y
fig|478004.5.peg.1442
Escherichia coli O157:H7 str. EC4401 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
Q
AAVE
GI
E
I
V
D
DI
Y
fig|478005.5.peg.2472
Escherichia coli O157:H7 str. EC4486 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
Q
AAVE
GI
E
I
V
D
DI
Y
fig|478006.5.peg.873
Escherichia coli O157:H7 str. EC4501 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
Q
AAVE
GI
E
I
V
D
DI
Y
fig|478007.5.peg.932
Escherichia coli O157:H7 str. EC508 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
Q
AAVE
GI
E
I
V
D
DI
Y
fig|478008.5.peg.1674
Escherichia coli O157:H7 str. EC869 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
Q
AAVE
GI
E
I
V
D
DI
Y
fig|637388.3.peg.1069
Escherichia coli O157:H7 str. FRIK2000 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
Q
AAVE
GI
E
I
V
D
DI
Y
fig|570506.3.peg.3606
Escherichia coli O157:H7 str. FRIK966 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
Q
AAVE
GI
E
I
V
D
DI
Y
fig|386585.9.peg.686
Escherichia coli O157:H7 str. Sakai (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
Q
AAVE
GI
E
I
V
D
DI
Y
fig|544404.4.peg.599
Escherichia coli O157:H7 str. TW14359 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
Q
AAVE
GI
E
I
V
D
DI
Y
fig|502346.5.peg.624
Escherichia coli O157:H7 str. TW14588 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
Q
AAVE
GI
E
I
V
D
DI
Y
fig|701177.3.peg.638
Escherichia coli O55:H7 str. CB9615 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
Q
AAVE
GI
E
I
V
D
DI
Y
fig|1040638.4.peg.5222
Escherichia coli O104:H4 str. LB226692 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
E
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
L
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|6666666.5357.peg.1693
Escherichia coli TY-2482 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
E
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
L
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|585055.6.peg.543
Escherichia coli 55989 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
E
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
L
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|585055.8.peg.544
Escherichia coli 55989 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
E
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
L
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|550672.3.peg.50
Escherichia coli B088 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
E
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
L
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|595495.4.peg.4208
Escherichia coli KO11 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
E
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
L
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|566546.3.peg.4387
Escherichia coli W (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
E
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
L
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|566546.4.peg.594
Escherichia coli W (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
E
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
L
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|679205.4.peg.226
Escherichia coli MS 124-1 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGN
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|749533.3.peg.1278
Escherichia coli MS 84-1 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGN
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|216592.1.peg.276
Escherichia coli 042 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
NA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|216592.3.peg.587
Escherichia coli 042 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
NA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|550676.3.peg.1326
Escherichia coli B185 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|656393.3.peg.1178
Escherichia coli H299 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
NA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|656419.3.peg.748
Escherichia coli M718 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|749531.3.peg.1530
Escherichia coli MS 69-1 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
K
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
NA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HIV
I
-
NP
N
F
F
SS
S
ELF
R
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|585057.4.peg.510
Escherichia coli IAI39 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
S
F
F
SS
S
ELF
S
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
fig|585057.6.peg.509
Escherichia coli IAI39 (1-328/349)
MKIS
R
ETLH
QL
I
EN
K
L
C
Q
A
G
L
K
R
E
H
A
AT
VAE
V
L
VY
A
DAR
G
IH
SHG
AV
R
V
E
Y
Y
A
E
RI
S
K
G
GTNR
E
PEF
R
LEETG
PC
SAI
L
H
AD
N
A
A
GQVAAK
MG
M
EH
AI
K
T
A
Q
Q
N
G
V
A
V
V
GI
S
R
MG
H
S
G
A
I
S
Y
F
VQ
QAA
R
AG
L
IGI
SMCQ
S
DP
---
MV
V
PFGG
A
E
I
Y
Y
GTNPL
A
F
A
A
P
GEGD
--
E
I
LTF
DMAT
T
VQ
A
W
GK
VL
D
AR
SR
N
MS
I
P
DTWAV
D
K
NG
A
PTTDP
F
A
V
---
--
HA
LLP
A
A
GP
KGYGL
MM
M
I
D
V
L
S
G
V
L
L
G
LPF
G
RQ
V
SSM
Y
D
D
L
H
AGRN
L
G
QL
HVV
I
-
NP
S
F
F
SS
S
ELF
S
Q
H
L
SQT
M
RE
L
N
A
IT
PA
P
GFNQ
V
Y
Y
PG
QDQDIKQ
R
K
AAVE
GI
E
I
V
D
DI
Y
Consen1
Primary consensus
mkis
etLh
i
vl
q
G
d
e
A
vAe
l
a
G
SHG
r
p
y
e
s
G
n
k
ga
ldadra
GqvaAk
M
aIe
A
q
Gia
Val
n
H
grigyw
QaA
aG
igI
s
---
mv
Pfgg
e
r
GTNPl
va
P
--
pi
Dmats
afGk
var
g
vP
D
nG
pTtdP
vm
--
lLp
a
KGygl
m
dml
g
Lsg
---
G
v
t
d
s
l
ql
I
np
lf
p
aq
-
m
v
a
pad
i
lPG
re
GI
idd
w
aIQAL
Consen2
Secondary consensus
lqvt
qq
k
f
kf
s
q
c
d
f
t
m
e
f
e
r
pc
whgqns
nlt
h
g
k
d
vg
gi
r
magss
c
k
vs
v
ip
vm
wha
d
y
f
fv
f
el
ysmt
s
m
dnw
n
e
l
k
a
pl
i
t
g
sam
v
e
i
t
ldlpf
t
y
q
h
i
c
vd
fi
s
rk
l
a
l
rhp
v
y
ak
va
y
k
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character