fig|1040638.4.peg.1597
Escherichia coli O104:H4 str. LB226692
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|6666666.5357.peg.1911
Escherichia coli TY-2482
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|358709.5.peg.48
Escherichia coli 101-1
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|670888.3.peg.2507
Escherichia coli 1827-70
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|585055.6.peg.4212
Escherichia coli 55989
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|585055.8.peg.4215
Escherichia coli 55989
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|481805.3.peg.4612
Escherichia coli ATCC 8739
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|481805.6.peg.4590
Escherichia coli ATCC 8739
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|413997.3.peg.3773
Escherichia coli B str. REL606
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|344601.3.peg.2401
Escherichia coli B171
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|344601.5.peg.2504
Escherichia coli B171
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|340184.3.peg.856
Escherichia coli B7A
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|340184.6.peg.889
Escherichia coli B7A
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|511693.5.peg.3791
Escherichia coli BL21
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|469008.4.peg.4496
Escherichia coli BL21(DE3)
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|340186.3.peg.2384
Escherichia coli E110019
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|340186.5.peg.2461
Escherichia coli E110019
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|340185.3.peg.2188
Escherichia coli E22
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|340185.4.peg.2316
Escherichia coli E22
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|331111.3.peg.1860
Escherichia coli E24377A
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|656408.3.peg.4169
Escherichia coli H591
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|331112.3.peg.3678
Escherichia coli HS
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|595495.4.peg.2745
Escherichia coli KO11
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|679207.4.peg.56
Escherichia coli MS 107-1
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|749537.3.peg.299
Escherichia coli MS 115-1
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|679204.3.peg.2872
Escherichia coli MS 145-7
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|749547.3.peg.4359
Escherichia coli MS 187-1
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|585395.4.peg.4654
Escherichia coli O103:H2 str. 12009
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|585396.4.peg.4699
Escherichia coli O111:H- str. 11128
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|573235.3.peg.5017
Escherichia coli O26:H11 str. 11368
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|409438.11.peg.4169
Escherichia coli SE11
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|656443.3.peg.4651
Escherichia coli TA271
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|566546.3.peg.3284
Escherichia coli W
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|566546.4.peg.3966
Escherichia coli W
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|679206.4.peg.4063
Escherichia coli MS 119-7
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLA
R
LR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|656444.3.peg.5055
Escherichia coli TA280
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|550677.3.peg.4300
Escherichia coli B354 (4-322/322)
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|331111.12.peg.4458
Escherichia coli E24377A (4-322/322)
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|331112.6.peg.3834
Escherichia coli HS (4-322/322)
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|656419.3.peg.4773
Escherichia coli M718 (4-322/322)
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|562.375.peg.282
Escherichia coli EC4100B
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWSLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|216592.3.peg.4219
Escherichia coli 042
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IK
H
LYASMA
fig|656379.3.peg.4568
Escherichia coli FVEC1302
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IK
H
LYASMA
fig|656380.3.peg.4851
Escherichia coli FVEC1412
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IK
H
LYASMA
fig|749549.3.peg.369
Escherichia coli MS 198-1
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IK
H
LYASMA
fig|585056.7.peg.4413
Escherichia coli UMN026
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IK
H
LYASMA
fig|656437.3.peg.4195
Escherichia coli TA143 (4-322/322)
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|216592.1.peg.1061
Escherichia coli 042 (4-322/322)
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IK
H
LYASMA
fig|595496.3.peg.3716
Escherichia coli BW2952
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
R
I
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HQTWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|536056.3.peg.4528
Escherichia coli DH1
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
R
I
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HQTWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|316401.4.peg.4542
Escherichia coli ETEC H10407
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
R
I
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HQTWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|656414.3.peg.4239
Escherichia coli H736
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
R
I
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HQTWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|83333.1.peg.3648
Escherichia coli K12
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
R
I
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HQTWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|749538.3.peg.1058
Escherichia coli MS 116-1
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
R
I
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HQTWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|749544.3.peg.2035
Escherichia coli MS 175-1
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
R
I
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HQTWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|749548.3.peg.4025
Escherichia coli MS 196-1
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
R
I
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HQTWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|316407.3.peg.3414
Escherichia coli W3110
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
R
I
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HQTWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|316385.7.peg.3933
Escherichia coli str. K-12 substr. DH10B
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
R
I
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HQTWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|511145.12.peg.3834
Escherichia coli str. K-12 substr. MG1655
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
R
I
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HQTWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|511145.6.peg.3816
Escherichia coli str. K-12 substr. MG1655
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
R
I
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HQTWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|550676.3.peg.3926
Escherichia coli B185
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
V
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|749531.3.peg.1906
Escherichia coli MS 69-1
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQE
H
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IK
H
LYASMA
fig|679205.4.peg.4400
Escherichia coli MS 124-1
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWSLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|749545.3.peg.3446
Escherichia coli MS 182-1
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWSLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|749532.3.peg.119
Escherichia coli MS 78-1
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWSLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|749533.3.peg.1089
Escherichia coli MS 84-1
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWSLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|525281.3.peg.3210
Escherichia coli 83972
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|655817.3.peg.4385
Escherichia coli ABU 83972
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|199310.4.peg.4351
Escherichia coli CFT073
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|749546.3.peg.1492
Escherichia coli MS 185-1
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|749527.3.peg.5283
Escherichia coli MS 21-1
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|753642.3.peg.4210
Escherichia coli NC101
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|585034.4.peg.3804
Escherichia coli IAI1
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LRR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|585034.5.peg.3801
Escherichia coli IAI1
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HETWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LRR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|656417.3.peg.4597
Escherichia coli M605
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
I
R
NLYASMA
fig|344610.3.peg.1856
Escherichia coli 53638
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
R
I
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
THG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HQTWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|344610.7.peg.2489
Escherichia coli 53638
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
R
I
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
THG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HQTWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|749540.3.peg.1002
Escherichia coli MS 146-1 (4-322/322)
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
R
I
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HQTWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
E
T
IKNLYASMA
fig|562.376.peg.2467
Escherichia coli WV_060327 (1-318/319)
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASM
fig|199310.1.peg.4535
Escherichia coli CFT073 (4-322/322)
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|656393.3.peg.4881
Escherichia coli H299 (4-322/322)
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|585057.4.peg.4450
Escherichia coli IAI39
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
I
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|585057.6.peg.4460
Escherichia coli IAI39
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
I
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|439855.10.peg.4220
Escherichia coli SMS-3-5
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
I
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|562.371.peg.3014
Escherichia coli 1044A
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEKWDLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
D
T
IKNLYASMA
fig|562.373.peg.941
Escherichia coli 1125A
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEKWDLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
D
T
IKNLYASMA
fig|562.372.peg.3899
Escherichia coli 1212A
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEKWDLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
D
T
IKNLYASMA
fig|562.374.peg.1988
Escherichia coli 536A
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEKWDLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
D
T
IKNLYASMA
fig|83334.1.peg.4619
Escherichia coli O157:H7
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEKWDLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
D
T
IKNLYASMA
fig|444454.5.peg.3740
Escherichia coli O157:H7 str. EC4024
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEKWDLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
D
T
IKNLYASMA
fig|444449.5.peg.3194
Escherichia coli O157:H7 str. EC4042
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEKWDLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
D
T
IKNLYASMA
fig|444448.5.peg.1950
Escherichia coli O157:H7 str. EC4045
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEKWDLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
D
T
IKNLYASMA
fig|444453.5.peg.1480
Escherichia coli O157:H7 str. EC4076
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEKWDLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
D
T
IKNLYASMA
fig|444452.5.peg.1618
Escherichia coli O157:H7 str. EC4113
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEKWDLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
D
T
IKNLYASMA
fig|444450.8.peg.5032
Escherichia coli O157:H7 str. EC4115
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEKWDLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
D
T
IKNLYASMA
fig|444451.5.peg.34
Escherichia coli O157:H7 str. EC4196
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEKWDLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
D
T
IKNLYASMA
fig|444447.5.peg.2113
Escherichia coli O157:H7 str. EC4206
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEKWDLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
D
T
IKNLYASMA
fig|478004.5.peg.507
Escherichia coli O157:H7 str. EC4401
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEKWDLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
D
T
IKNLYASMA
fig|478006.5.peg.491
Escherichia coli O157:H7 str. EC4501
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEKWDLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
D
T
IKNLYASMA
fig|478007.5.peg.1550
Escherichia coli O157:H7 str. EC508
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEKWDLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
D
T
IKNLYASMA
fig|478008.5.peg.1833
Escherichia coli O157:H7 str. EC869
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEKWDLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
D
T
IKNLYASMA
fig|637388.3.peg.2970
Escherichia coli O157:H7 str. FRIK2000
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEKWDLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
D
T
IKNLYASMA
fig|570506.3.peg.4762
Escherichia coli O157:H7 str. FRIK966
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEKWDLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
D
T
IKNLYASMA
fig|386585.9.peg.4857
Escherichia coli O157:H7 str. Sakai
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEKWDLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
D
T
IKNLYASMA
fig|544404.4.peg.4842
Escherichia coli O157:H7 str. TW14359
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEKWDLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
D
T
IKNLYASMA
fig|502346.5.peg.1965
Escherichia coli O157:H7 str. TW14588
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEKWDLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
D
T
IKNLYASMA
fig|701177.3.peg.4524
Escherichia coli O55:H7 str. CB9615
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEKWDLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
D
T
IKNLYASMA
fig|749528.3.peg.2854
Escherichia coli MS 45-1
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YS
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|155864.1.peg.4655
Escherichia coli O157:H7 EDL933
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
XRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEKWDLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
D
T
IKNLYASMA
fig|155864.8.peg.4615
Escherichia coli O157:H7 EDL933
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KQ
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
XRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEKWDLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
HN
P
KIV
WL
R
D
T
IKNLYASMA
fig|216593.1.peg.4520
Escherichia coli E2348/69 (4-322/322)
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
W
M
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|405955.9.peg.3485
Escherichia coli APEC O1
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
Q
L
LDK
P
LHETPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|585397.7.peg.4397
Escherichia coli ED1a
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
Q
L
LDK
P
LHETPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|585397.9.peg.4394
Escherichia coli ED1a
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
Q
L
LDK
P
LHETPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|714962.3.peg.4202
Escherichia coli IHE3034
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
Q
L
LDK
P
LHETPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|869729.3.peg.4020
Escherichia coli UM146
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
Q
L
LDK
P
LHETPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|364106.7.peg.4169
Escherichia coli UTI89
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
Q
L
LDK
P
LHETPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|364106.8.peg.4171
Escherichia coli UTI89
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
Q
L
LDK
P
LHETPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|670897.3.peg.3553
Escherichia coli 2362-75
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
W
M
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
L
L
LDK
P
HHQTPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEPSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|405955.13.peg.4167
Escherichia coli APEC O1 (4-322/322)
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
Q
L
LDK
P
LHETPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|585035.6.peg.4064
Escherichia coli S88 (4-322/322)
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPSAVS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
Q
L
LDK
P
LHETPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|431946.3.peg.3702
Escherichia coli SE15
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
NVTPS
S
VS
K
SLAKLR
A
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
Q
L
LDK
P
LHETPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPL
S
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|362663.8.peg.3940
Escherichia coli 536
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
S
VTPSAVS
K
SLAKLR
M
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
Q
L
LDK
P
LHETPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|362663.9.peg.3955
Escherichia coli 536
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
S
VTPSAVS
K
SLAKLR
M
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
Q
L
LDK
P
LHETPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|340197.3.peg.442
Escherichia coli F11
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
S
VTPSAVS
K
SLAKLR
M
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
Q
L
LDK
P
LHETPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|340197.5.peg.454
Escherichia coli F11
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
S
VTPSAVS
K
SLAKLR
M
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
Q
L
LDK
P
LHETPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|749550.3.peg.2371
Escherichia coli MS 200-1
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
S
VTPSAVS
K
SLAKLR
M
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
Q
L
LDK
P
LHETPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|685038.3.peg.3776
Escherichia coli O83:H1 str. NRG 857C
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
S
VTPSAVS
K
SLAKLR
M
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
Q
L
LDK
P
LHETPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|656440.3.peg.4026
Escherichia coli TA206
MKK
S
IT
T
LDLNLL
L
C
L
Q
LL
MQER
S
V
T
K
AAK
RM
S
VTPSAVS
K
SLAKLR
M
W
F
D
DPLFV
N
S
P
L
GL
S
PT
P
L
M
VS
M
EQN
L
A
E
W
M
Q
-
M
S
N
Q
L
LDK
P
LHETPRG
L
K
F
E
LA
AE
SPL
MM
IML
NA
LS
KR
I
Y
Q
R
YPQ
ATIK
LRN
-WDY
DS
L
D
AI
TRG
E
V
D
IG
F
S
GRES
H
P
R
S
RELLSSLPLA
IDYE
VLF
S
D
V
PCV
WL
RK
D
HP
A
L
HEAWNLD
T
FL
R
YP
H
IS
I
CW
E
QSD
T
WA
L
D
N
VL
QE
LGR
E
R
T
IA
M
S
LPEFEQSLFM
A
A
Q
PD
N
L
LLA
T
APR
Y
CQ
Y
YN
Q
L
H
Q
-
LPL
VA
LPLP
-
F
D
E
S
Q
QKKLE
VP
F
T
L
L
WHK
R
N
S
R
N
P
KIV
WL
R
E
T
IKNLYASMA
fig|344601.3.peg.2241
Escherichia coli B171 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
LTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|344601.5.peg.2343
Escherichia coli B171 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
LTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|340185.3.peg.1707
Escherichia coli E22 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
LTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|340185.4.peg.1800
Escherichia coli E22 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
LTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|585395.4.peg.668
Escherichia coli O103:H2 str. 12009 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
LTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|439855.10.peg.819
Escherichia coli SMS-3-5 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
S
H
YPQ
L--L
LRN
PPTS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
IL
L
LP
E
GQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|656379.3.peg.1411
Escherichia coli FVEC1302 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
S
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
IL
L
LP
E
GQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|656380.3.peg.1240
Escherichia coli FVEC1412 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
S
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
IL
L
LP
E
GQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|585057.4.peg.644
Escherichia coli IAI39 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
S
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
IL
L
LP
E
GQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|585057.6.peg.642
Escherichia coli IAI39 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
S
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
IL
L
LP
E
GQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|749549.3.peg.4895
Escherichia coli MS 198-1 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
S
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
IL
L
LP
E
GQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|749527.3.peg.4171
Escherichia coli MS 21-1 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
S
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
IL
L
LP
E
GQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|749531.3.peg.4073
Escherichia coli MS 69-1 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
S
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
IL
L
LP
E
GQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|656437.3.peg.708
Escherichia coli TA143 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
S
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
IL
L
LP
E
GQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|656444.3.peg.1170
Escherichia coli TA280 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
S
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
IL
L
LP
E
GQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|585056.7.peg.920
Escherichia coli UMN026 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
S
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
IL
L
LP
E
GQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|656393.3.peg.1309
Escherichia coli H299 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
IL
L
LP
E
GQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|670888.3.peg.1198
Escherichia coli 1827-70 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|344610.3.peg.1618
Escherichia coli 53638 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|344610.7.peg.1060
Escherichia coli 53638 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|481805.3.peg.3234
Escherichia coli ATCC 8739 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|481805.6.peg.3221
Escherichia coli ATCC 8739 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|340184.3.peg.2410
Escherichia coli B7A (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|340184.6.peg.2530
Escherichia coli B7A (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|595496.3.peg.555
Escherichia coli BW2952 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|536056.3.peg.3168
Escherichia coli DH1 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|340186.3.peg.2283
Escherichia coli E110019 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|340186.5.peg.2356
Escherichia coli E110019 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|316401.4.peg.753
Escherichia coli ETEC H10407 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|656414.3.peg.809
Escherichia coli H736 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|331112.3.peg.636
Escherichia coli HS (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|331112.6.peg.664
Escherichia coli HS (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|585034.4.peg.607
Escherichia coli IAI1 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|585034.5.peg.606
Escherichia coli IAI1 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|83333.1.peg.630
Escherichia coli K12 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|595495.4.peg.1983
Escherichia coli KO11 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|749538.3.peg.4242
Escherichia coli MS 116-1 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|679205.4.peg.637
Escherichia coli MS 124-1 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|679204.3.peg.2635
Escherichia coli MS 145-7 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|749540.3.peg.606
Escherichia coli MS 146-1 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|749545.3.peg.5002
Escherichia coli MS 182-1 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|749548.3.peg.4500
Escherichia coli MS 196-1 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|749532.3.peg.3705
Escherichia coli MS 78-1 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|749533.3.peg.5440
Escherichia coli MS 84-1 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|585396.4.peg.684
Escherichia coli O111:H- str. 11128 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|573235.3.peg.711
Escherichia coli O26:H11 str. 11368 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|656443.3.peg.888
Escherichia coli TA271 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|566546.3.peg.2818
Escherichia coli W (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|566546.4.peg.688
Escherichia coli W (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|316407.3.peg.614
Escherichia coli W3110 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|316385.5.peg.585
Escherichia coli str. K-12 substr. DH10B (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|316385.5.peg.696
Escherichia coli str. K-12 substr. DH10B (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|316385.7.peg.594
Escherichia coli str. K-12 substr. DH10B (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|316385.7.peg.705
Escherichia coli str. K-12 substr. DH10B (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|511145.12.peg.659
Escherichia coli str. K-12 substr. MG1655 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|511145.6.peg.650
Escherichia coli str. K-12 substr. MG1655 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|562.371.peg.2889
Escherichia coli 1044A (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RI
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|562.373.peg.3104
Escherichia coli 1125A (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RI
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|562.372.peg.1621
Escherichia coli 1212A (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RI
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|562.374.peg.5357
Escherichia coli 536A (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RI
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|550676.3.peg.96
Escherichia coli B185 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RI
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|83334.1.peg.743
Escherichia coli O157:H7 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RI
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|155864.8.peg.680
Escherichia coli O157:H7 EDL933 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RI
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|444449.5.peg.5491
Escherichia coli O157:H7 str. EC4042 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RI
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|444448.5.peg.3365
Escherichia coli O157:H7 str. EC4045 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RI
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|444453.5.peg.707
Escherichia coli O157:H7 str. EC4076 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RI
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|444450.8.peg.825
Escherichia coli O157:H7 str. EC4115 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RI
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|444447.5.peg.3543
Escherichia coli O157:H7 str. EC4206 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RI
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|478004.5.peg.1533
Escherichia coli O157:H7 str. EC4401 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RI
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|478005.5.peg.4046
Escherichia coli O157:H7 str. EC4486 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RI
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|478008.5.peg.1767
Escherichia coli O157:H7 str. EC869 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RI
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|637388.3.peg.1162
Escherichia coli O157:H7 str. FRIK2000 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RI
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|570506.3.peg.3699
Escherichia coli O157:H7 str. FRIK966 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RI
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|386585.9.peg.778
Escherichia coli O157:H7 str. Sakai (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RI
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|544404.4.peg.690
Escherichia coli O157:H7 str. TW14359 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RI
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|502346.5.peg.530
Escherichia coli O157:H7 str. TW14588 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RI
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|701177.3.peg.791
Escherichia coli O55:H7 str. CB9615 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RI
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|331111.12.peg.957
Escherichia coli E24377A (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
D
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|331111.3.peg.3179
Escherichia coli E24377A (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
D
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|749537.3.peg.4029
Escherichia coli MS 115-1 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
F
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|550672.3.peg.200
Escherichia coli B088 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
T
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|562.375.peg.1526
Escherichia coli EC4100B (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
T
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|656408.3.peg.566
Escherichia coli H591 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
T
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|679207.4.peg.2828
Escherichia coli MS 107-1 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
T
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|679206.4.peg.2835
Escherichia coli MS 119-7 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
T
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|1040638.4.peg.5324
Escherichia coli O104:H4 str. LB226692 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
A
I
D
V
I
R
N
AF
fig|6666666.5357.peg.4708
Escherichia coli TY-2482 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
A
I
D
V
I
R
N
AF
fig|585055.6.peg.633
Escherichia coli 55989 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
A
I
D
V
I
R
N
AF
fig|585055.8.peg.634
Escherichia coli 55989 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
A
I
D
V
I
R
N
AF
fig|216592.1.peg.387
Escherichia coli 042 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
S
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDYRE
T
ID
N
AA
H
IL
L
LP
E
GQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|216592.3.peg.692
Escherichia coli 042 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
S
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDYRE
T
ID
N
AA
H
IL
L
LP
E
GQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|550677.3.peg.1048
Escherichia coli B354 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRG
T
ID
N
AA
H
IL
L
LP
E
GQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
IS
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|358709.5.peg.1919
Escherichia coli 101-1 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRG
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|413997.3.peg.629
Escherichia coli B str. REL606 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRG
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|511693.5.peg.626
Escherichia coli BL21 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRG
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|469008.4.peg.3130
Escherichia coli BL21(DE3) (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRG
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|749547.3.peg.3673
Escherichia coli MS 187-1 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRG
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|637912.3.peg.3059
Escherichia coli OP50 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
TPSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRG
T
ID
N
AA
H
VL
L
LP
E
GQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
V
I
D
V
I
R
N
AF
fig|409438.11.peg.820
Escherichia coli SE11 (25-317/317)
T
LR
N
I
DLNLLT
I
F
E
AV
YVH
K
G
I
V
N
AAKVLN
L
A
PSA
I
S
Q
S
I
Q
KLRV
I
F
P
DPLF
I
R
K
G
Q
G
V
T
PTA
F
A
MH
L
HEY
I
S
Q
G
L
E
S
I
L
G
A
L
DIE
G
--SYDKQ
R
T
I
T
I
A
TT
PSV
GA
L
V
L
PV
IY
RA
I
K
T
H
YPQ
L--L
LRN
PPIS
D
A
E
N
QL
SQF
Q
TD
LI
I
D
NMFC
T
N
R
T
----------
VQHH
VLF
T
D
N
MVL
IC
R
E
G
N
P
L
L
SLEDDRE
T
ID
N
AA
H
VL
L
LP
E
EQN
F
SG
L
R
Q
RV
QE
MFP
DRQ
--
I
N
FTSYNILTIA
A
L
V
AN
S
D
M
LAI
I
P
S
R
--
F
YN
L
F
S
R
C
W
PL
EK
LP
F
P
S
L
N
E
E
Q
-----
ID
F
S
I
H
YN
K
F
S
L
RDP
ILH
G
A
I
D
V
I
R
N
AF
fig|670897.3.peg.1896
Escherichia coli 2362-75 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|362663.8.peg.84
Escherichia coli 536 (22-314/320)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|362663.9.peg.84
Escherichia coli 536 (22-314/320)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|525281.3.peg.1191
Escherichia coli 83972 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|655817.3.peg.87
Escherichia coli ABU 83972 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|405955.13.peg.85
Escherichia coli APEC O1 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|405955.9.peg.65
Escherichia coli APEC O1 (44-336/342)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|199310.1.peg.90
Escherichia coli CFT073 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|199310.4.peg.88
Escherichia coli CFT073 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|216593.1.peg.3496
Escherichia coli E2348/69 (44-336/342)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|340197.3.peg.4333
Escherichia coli F11 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|340197.5.peg.4526
Escherichia coli F11 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|714962.3.peg.83
Escherichia coli IHE3034 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|749546.3.peg.2384
Escherichia coli MS 185-1 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|749550.3.peg.2594
Escherichia coli MS 200-1 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|749528.3.peg.2229
Escherichia coli MS 45-1 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|753642.3.peg.3557
Escherichia coli NC101 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|574521.7.peg.84
Escherichia coli O127:H6 str. E2348/69 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|685038.3.peg.77
Escherichia coli O83:H1 str. NRG 857C (22-314/320)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|585035.6.peg.87
Escherichia coli S88 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|431946.3.peg.86
Escherichia coli SE15 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|656440.3.peg.5136
Escherichia coli TA206 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|869729.3.peg.4985
Escherichia coli UM146 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|364106.7.peg.216
Escherichia coli UTI89 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|364106.8.peg.215
Escherichia coli UTI89 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|562.376.peg.1232
Escherichia coli WV_060327 (22-314/320)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|656393.3.peg.691
Escherichia coli H299 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
TW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|749527.3.peg.3175
Escherichia coli MS 21-1 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NQ
I
E
Q
T
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|585057.4.peg.89
Escherichia coli IAI39 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
T
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|585057.6.peg.88
Escherichia coli IAI39 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
T
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|439855.10.peg.257
Escherichia coli SMS-3-5 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
T
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|656417.3.peg.140
Escherichia coli M605 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
A
L
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|1040638.4.peg.5637
Escherichia coli O104:H4 str. LB226692 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|6666666.5357.peg.1773
Escherichia coli TY-2482 (22-314/320)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|358709.5.peg.4140
Escherichia coli 101-1 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|670888.3.peg.656
Escherichia coli 1827-70 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|585055.6.peg.78
Escherichia coli 55989 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|585055.8.peg.78
Escherichia coli 55989 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|481805.3.peg.3845
Escherichia coli ATCC 8739 (44-336/342)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|481805.6.peg.3824
Escherichia coli ATCC 8739 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|413997.3.peg.83
Escherichia coli B str. REL606 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|550672.3.peg.4348
Escherichia coli B088 (75-367/373)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|344601.3.peg.3703
Escherichia coli B171 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|344601.5.peg.3872
Escherichia coli B171 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|550677.3.peg.466
Escherichia coli B354 (22-314/320)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|340184.3.peg.2849
Escherichia coli B7A (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|340184.6.peg.2981
Escherichia coli B7A (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|511693.5.peg.84
Escherichia coli BL21 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|469008.4.peg.3661
Escherichia coli BL21(DE3) (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|595496.3.peg.81
Escherichia coli BW2952 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|536056.3.peg.3724
Escherichia coli DH1 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|340186.3.peg.4045
Escherichia coli E110019 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|340186.5.peg.4253
Escherichia coli E110019 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|340185.3.peg.4256
Escherichia coli E22 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|340185.4.peg.4489
Escherichia coli E22 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|331111.12.peg.409
Escherichia coli E24377A (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|331111.3.peg.2648
Escherichia coli E24377A (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|562.375.peg.2578
Escherichia coli EC4100B (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|316401.4.peg.84
Escherichia coli ETEC H10407 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|656379.3.peg.318
Escherichia coli FVEC1302 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|656380.3.peg.256
Escherichia coli FVEC1412 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|656408.3.peg.5029
Escherichia coli H591 (22-314/320)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|656414.3.peg.196
Escherichia coli H736 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|331112.3.peg.77
Escherichia coli HS (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|331112.6.peg.82
Escherichia coli HS (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|585034.4.peg.78
Escherichia coli IAI1 (22-314/320)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|585034.5.peg.78
Escherichia coli IAI1 (22-314/320)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|83333.1.peg.77
Escherichia coli K12 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|595495.4.peg.1649
Escherichia coli KO11 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|656419.3.peg.234
Escherichia coli M718 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|679207.4.peg.1115
Escherichia coli MS 107-1 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|749537.3.peg.3171
Escherichia coli MS 115-1 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|749538.3.peg.3060
Escherichia coli MS 116-1 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|679206.4.peg.1695
Escherichia coli MS 119-7 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|679205.4.peg.2339
Escherichia coli MS 124-1 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|679204.3.peg.3193
Escherichia coli MS 145-7 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|749545.3.peg.1307
Escherichia coli MS 182-1 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|749547.3.peg.3864
Escherichia coli MS 187-1 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|749548.3.peg.4244
Escherichia coli MS 196-1 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|749549.3.peg.4574
Escherichia coli MS 198-1 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|749531.3.peg.4538
Escherichia coli MS 69-1 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|749532.3.peg.4190
Escherichia coli MS 78-1 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|749533.3.peg.3359
Escherichia coli MS 84-1 (22-314/320)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|585395.4.peg.78
Escherichia coli O103:H2 str. 12009 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|585396.4.peg.79
Escherichia coli O111:H- str. 11128 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|573235.3.peg.80
Escherichia coli O26:H11 str. 11368 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|637912.3.peg.504
Escherichia coli OP50 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|409438.11.peg.195
Escherichia coli SE11 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|656437.3.peg.137
Escherichia coli TA143 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|656443.3.peg.206
Escherichia coli TA271 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|656444.3.peg.412
Escherichia coli TA280 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|585056.7.peg.267
Escherichia coli UMN026 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|566546.3.peg.1656
Escherichia coli W (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|566546.4.peg.74
Escherichia coli W (22-314/320)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|316407.3.peg.76
Escherichia coli W3110 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|511145.12.peg.79
Escherichia coli str. K-12 substr. MG1655 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|511145.6.peg.80
Escherichia coli str. K-12 substr. MG1655 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|749544.3.peg.1713
Escherichia coli MS 175-1 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
N
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FCS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
Q
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|216592.1.peg.4334
Escherichia coli 042 (44-336/342)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|216592.3.peg.87
Escherichia coli 042 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|562.371.peg.4014
Escherichia coli 1044A (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|562.373.peg.2191
Escherichia coli 1125A (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|562.372.peg.3042
Escherichia coli 1212A (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|562.374.peg.2233
Escherichia coli 536A (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|550676.3.peg.4745
Escherichia coli B185 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|83334.1.peg.168
Escherichia coli O157:H7 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|155864.1.peg.80
Escherichia coli O157:H7 EDL933 (22-314/320)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|155864.8.peg.81
Escherichia coli O157:H7 EDL933 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|444454.5.peg.4544
Escherichia coli O157:H7 str. EC4024 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|444449.5.peg.3993
Escherichia coli O157:H7 str. EC4042 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|444448.5.peg.2752
Escherichia coli O157:H7 str. EC4045 (22-314/320)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|444453.5.peg.3355
Escherichia coli O157:H7 str. EC4076 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|444452.5.peg.4321
Escherichia coli O157:H7 str. EC4113 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|444450.8.peg.222
Escherichia coli O157:H7 str. EC4115 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|444451.5.peg.4396
Escherichia coli O157:H7 str. EC4196 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|444447.5.peg.2920
Escherichia coli O157:H7 str. EC4206 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|478004.5.peg.2452
Escherichia coli O157:H7 str. EC4401 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|478005.5.peg.4948
Escherichia coli O157:H7 str. EC4486 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|478006.5.peg.4390
Escherichia coli O157:H7 str. EC4501 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|478007.5.peg.4110
Escherichia coli O157:H7 str. EC508 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|386585.9.peg.180
Escherichia coli O157:H7 str. Sakai (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|544404.4.peg.84
Escherichia coli O157:H7 str. TW14359 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|502346.5.peg.1183
Escherichia coli O157:H7 str. TW14588 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|701177.3.peg.81
Escherichia coli O55:H7 str. CB9615 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNQ
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|478008.5.peg.4667
Escherichia coli O157:H7 str. EC869 (22-314/320)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNP
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|637388.3.peg.3919
Escherichia coli O157:H7 str. FRIK2000 (16-308/314)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNP
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
fig|570506.3.peg.1083
Escherichia coli O157:H7 str. FRIK966 (22-314/320)
K
P
Q
LR
M
V
DLNLLT
V
F
D
AVMQE
Q
N
IT
R
AA
H
VL
G
M
SQP
AVS
N
A
V
A
R
L
K
V
M
F
N
D
E
LFVR
Y
G
R
G
I
Q
PTA
R
A
FQ
L
FGS
V
R
Q
A
LQ
L
V
Q
N
E
L
PGS
G
FEPASSE
R
V
F
H
L
C
VC
SPL
DS
I
L
T
SQ
IY
NH
I
E
Q
I
A
P
N
IHVM
FKS
SLNP
N
T
E
H
QL
RYQ
ET
E
FV
IS
YEDF
H
R
P
E
----------
FTSV
P
LF
K
D
E
MVL
VA
S
K
N
HP
T
I
KGPLLKH
D
VY
N
EQ
H
AA
V
--
S
LDR
F
AS
F
S
Q
PW
YD
TV-
D
K
Q
AS
I
A
YQGMAMMSVL
S
V
V
SQ
T
H
L
V
AIAPR
W
--
L
AE
E
F
A
E
S
L
E
L
QV
LPLP
-
L
K
L
N
S
-----
RT
C
Y
L
S
WH
E
A
A
G
RD
K
GHQ
W
M
E
E
Q
L
Consen1
Primary consensus
MKk
lr
lDLNLLt
fqavmqer
it
AAkvlnvtpsAvS
slakLrv
F
DpLFvr
g
Gl
PTa
a
l
l
q
lq
m
n
L
g
r
f
la
spl
iml
iy
I
q
yPq
lrn
dsedql
etd
is
h
r
----------
vLF
D
mvl
rk
hP
l
t
n
H
i
e
f
l
q
qe
drq
is
a
v
n
llAiaPr
--
yn
f
q
lpL
LPlP
-
l
e
q
-----
f
l
whk
n
rdp
wl
e
ikNlyASMA
Consen2
Secondary consensus
p
it
l
l
llyvh
vv
hrmg
sqp
i
a
qr
ka
e
in
p
p
m
m
e
me
g
p
l
i
ic
psv
l
t
ls
t
a
n
fks
n
l
ai
qve
fd
t
p
rellsslpla
p
pcv
se
n
i
d
r
s
t
f
n
yd
ekt
m
s
q
mv
ti
s
cq
ae
l
we
f
sf
q
sqkkle
c
i
yne
hnk
g
d
lr
af
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character