fig|344601.3.peg.2402
Escherichia coli B171
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IA
D
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|344601.5.peg.2505
Escherichia coli B171
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IA
D
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|340185.3.peg.2187
Escherichia coli E22
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IA
D
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|340185.4.peg.2315
Escherichia coli E22
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IA
D
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|595495.4.peg.2746
Escherichia coli KO11
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IA
D
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|585395.4.peg.4655
Escherichia coli O103:H2 str. 12009
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IA
D
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|566546.3.peg.3285
Escherichia coli W
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IA
D
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|566546.4.peg.3965
Escherichia coli W
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IA
D
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|1040638.4.peg.1596
Escherichia coli O104:H4 str. LB226692
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|6666666.5357.peg.1912
Escherichia coli TY-2482
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|585055.6.peg.4211
Escherichia coli 55989
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|585055.8.peg.4214
Escherichia coli 55989
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|595496.3.peg.3715
Escherichia coli BW2952
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|536056.3.peg.4529
Escherichia coli DH1
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|316401.4.peg.4541
Escherichia coli ETEC H10407
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|656414.3.peg.4238
Escherichia coli H736
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|83333.1.peg.3647
Escherichia coli K12
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|679205.4.peg.4401
Escherichia coli MS 124-1
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|749540.3.peg.1001
Escherichia coli MS 146-1
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|749548.3.peg.4024
Escherichia coli MS 196-1
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|749533.3.peg.1090
Escherichia coli MS 84-1
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|409438.11.peg.4168
Escherichia coli SE11
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|656443.3.peg.4650
Escherichia coli TA271
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|316407.3.peg.3415
Escherichia coli W3110
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|316385.5.peg.3847
Escherichia coli str. K-12 substr. DH10B
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|316385.7.peg.3932
Escherichia coli str. K-12 substr. DH10B
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|511145.12.peg.3833
Escherichia coli str. K-12 substr. MG1655
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|511145.6.peg.3815
Escherichia coli str. K-12 substr. MG1655
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|358709.5.peg.49
Escherichia coli 101-1
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|670888.3.peg.2508
Escherichia coli 1827-70
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|481805.3.peg.4613
Escherichia coli ATCC 8739
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|481805.6.peg.4591
Escherichia coli ATCC 8739
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|413997.3.peg.3772
Escherichia coli B str. REL606
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|550672.3.peg.3784
Escherichia coli B088
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|340184.3.peg.857
Escherichia coli B7A
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|340184.6.peg.890
Escherichia coli B7A
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|511693.5.peg.3790
Escherichia coli BL21
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|469008.4.peg.4497
Escherichia coli BL21(DE3)
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|562.375.peg.283
Escherichia coli EC4100B
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|331112.3.peg.3677
Escherichia coli HS
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|331112.6.peg.3833
Escherichia coli HS
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|656419.3.peg.4772
Escherichia coli M718
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|679207.4.peg.57
Escherichia coli MS 107-1
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|749537.3.peg.300
Escherichia coli MS 115-1
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|679204.3.peg.2873
Escherichia coli MS 145-7
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|749545.3.peg.3445
Escherichia coli MS 182-1
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
S
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|749547.3.peg.4358
Escherichia coli MS 187-1
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|749532.3.peg.120
Escherichia coli MS 78-1
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
S
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|637912.3.peg.796
Escherichia coli OP50
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|344610.3.peg.1857
Escherichia coli 53638
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
V
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|344610.7.peg.2490
Escherichia coli 53638
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
V
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|340186.3.peg.2383
Escherichia coli E110019
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|340186.5.peg.2460
Escherichia coli E110019
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|331111.12.peg.4457
Escherichia coli E24377A
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|331111.3.peg.1859
Escherichia coli E24377A
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|585034.4.peg.3803
Escherichia coli IAI1
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|585034.5.peg.3800
Escherichia coli IAI1
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|585396.4.peg.4698
Escherichia coli O111:H- str. 11128
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|573235.3.peg.5018
Escherichia coli O26:H11 str. 11368
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|656379.3.peg.4567
Escherichia coli FVEC1302
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AV
L
MLS
LF
I
LKETRP
AAPTN
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|656380.3.peg.4850
Escherichia coli FVEC1412
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AV
L
MLS
LF
I
LKETRP
AAPTN
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|749549.3.peg.368
Escherichia coli MS 198-1
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AV
L
MLS
LF
I
LKETRP
AAPTN
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|585056.7.peg.4412
Escherichia coli UMN026
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AV
L
MLS
LF
I
LKETRP
AAPTN
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|749527.3.peg.5282
Escherichia coli MS 21-1
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|749544.3.peg.2036
Escherichia coli MS 175-1
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
L
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|749538.3.peg.1059
Escherichia coli MS 116-1
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
G
F
P
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
A
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
L
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|656393.3.peg.4880
Escherichia coli H299
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPTT
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
T
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRP
I
AAHEEIHHHA
fig|362663.8.peg.3939
Escherichia coli 536
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|362663.9.peg.3954
Escherichia coli 536
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|656417.3.peg.4596
Escherichia coli M605
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|753642.3.peg.4211
Escherichia coli NC101
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|656440.3.peg.4025
Escherichia coli TA206
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|562.376.peg.2468
Escherichia coli WV_060327
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|749531.3.peg.1907
Escherichia coli MS 69-1
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
G
F
P
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AV
L
MLS
LF
I
LKETRP
AAPTT
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
L
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|585057.4.peg.4449
Escherichia coli IAI39
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AI
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
I
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
F
I
APGRPVAAHEEIHHHA
fig|585057.6.peg.4459
Escherichia coli IAI39
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AI
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
I
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
F
I
APGRPVAAHEEIHHHA
fig|670897.3.peg.3554
Escherichia coli 2362-75
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AV
L
MLS
LF
I
LKETRP
AAPTT
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|216593.1.peg.4519
Escherichia coli E2348/69
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AV
L
MLS
LF
I
LKETRP
AAPTT
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|574521.7.peg.4099
Escherichia coli O127:H6 str. E2348/69
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AV
L
MLS
LF
I
LKETRP
AAPTT
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|656437.3.peg.4194
Escherichia coli TA143
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
L
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|340197.3.peg.443
Escherichia coli F11
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TAS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|340197.5.peg.455
Escherichia coli F11
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TAS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|749550.3.peg.2370
Escherichia coli MS 200-1
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TAS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|656408.3.peg.4168
Escherichia coli H591
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
AKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|679206.4.peg.4064
Escherichia coli MS 119-7
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
MMG
I
AV
L
MLS
LF
I
LKETRP
ASPAA
S
AKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|525281.3.peg.3209
Escherichia coli 83972
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LN
F
P
W
QS
LFW
T
MA
IMG
V
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|655817.3.peg.4384
Escherichia coli ABU 83972
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LN
F
P
W
QS
LFW
T
MA
IMG
V
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|199310.1.peg.4534
Escherichia coli CFT073
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LN
F
P
W
QS
LFW
T
MA
IMG
V
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|199310.4.peg.4350
Escherichia coli CFT073
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LN
F
P
W
QS
LFW
T
MA
IMG
V
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|585397.7.peg.4396
Escherichia coli ED1a
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LN
F
P
W
QS
LFW
T
MA
IMG
V
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|585397.9.peg.4393
Escherichia coli ED1a
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LN
F
P
W
QS
LFW
T
MA
IMG
V
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|749546.3.peg.1491
Escherichia coli MS 185-1
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LN
F
P
W
QS
LFW
T
MA
IMG
V
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|749528.3.peg.2855
Escherichia coli MS 45-1
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LN
F
P
W
QS
LFW
T
MA
IMG
V
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|550677.3.peg.4299
Escherichia coli B354
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AV
L
MLS
LF
I
LKETRP
AALAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|405955.13.peg.4166
Escherichia coli APEC O1
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AL
L
MLS
LF
I
LKETRP
AAPTT
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|405955.9.peg.3484
Escherichia coli APEC O1
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AL
L
MLS
LF
I
LKETRP
AAPTT
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|714962.3.peg.4201
Escherichia coli IHE3034
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AL
L
MLS
LF
I
LKETRP
AAPTT
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|685038.3.peg.3775
Escherichia coli O83:H1 str. NRG 857C
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AL
L
MLS
LF
I
LKETRP
AAPTT
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|585035.6.peg.4063
Escherichia coli S88
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AL
L
MLS
LF
I
LKETRP
AAPTT
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|869729.3.peg.4019
Escherichia coli UM146
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AL
L
MLS
LF
I
LKETRP
AAPTT
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|364106.7.peg.4168
Escherichia coli UTI89
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AL
L
MLS
LF
I
LKETRP
AAPTT
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|364106.8.peg.4170
Escherichia coli UTI89
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AL
L
MLS
LF
I
LKETRP
AAPTT
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|216592.1.peg.1060
Escherichia coli 042
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
L
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSH
V
VSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|216592.3.peg.4218
Escherichia coli 042
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
L
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSH
V
VSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|431946.3.peg.3701
Escherichia coli SE15
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
AL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHH
N
A
fig|550676.3.peg.3925
Escherichia coli B185
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QML
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|656444.3.peg.5054
Escherichia coli TA280
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AV
L
MLS
LF
I
LKETRP
AALAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSH
V
VSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|562.371.peg.3015
Escherichia coli 1044A
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
T
SV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
TVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
SA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|562.373.peg.942
Escherichia coli 1125A
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
T
SV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
TVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
SA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|562.372.peg.3900
Escherichia coli 1212A
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
T
SV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
TVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
SA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|562.374.peg.1989
Escherichia coli 536A
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
T
SV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
TVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
SA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|83334.1.peg.4618
Escherichia coli O157:H7
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
T
SV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
TVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
SA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|155864.1.peg.4654
Escherichia coli O157:H7 EDL933
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
T
SV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
TVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
SA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|155864.8.peg.4614
Escherichia coli O157:H7 EDL933
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
T
SV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
TVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
SA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|444454.5.peg.3739
Escherichia coli O157:H7 str. EC4024
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
T
SV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
TVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
SA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|444449.5.peg.3193
Escherichia coli O157:H7 str. EC4042
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
T
SV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
TVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
SA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|444448.5.peg.1949
Escherichia coli O157:H7 str. EC4045
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
T
SV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
TVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
SA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|444453.5.peg.1479
Escherichia coli O157:H7 str. EC4076
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
T
SV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
TVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
SA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|444452.5.peg.1619
Escherichia coli O157:H7 str. EC4113
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
T
SV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
TVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
SA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|444450.8.peg.5031
Escherichia coli O157:H7 str. EC4115
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
T
SV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
TVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
SA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|444451.5.peg.35
Escherichia coli O157:H7 str. EC4196
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
T
SV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
TVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
SA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|444447.5.peg.2112
Escherichia coli O157:H7 str. EC4206
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
T
SV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
TVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
SA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|478004.5.peg.506
Escherichia coli O157:H7 str. EC4401
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
T
SV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
TVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
SA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|478005.5.peg.441
Escherichia coli O157:H7 str. EC4486
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
T
SV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
TVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
SA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|478006.5.peg.490
Escherichia coli O157:H7 str. EC4501
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
T
SV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
TVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
SA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|478007.5.peg.1549
Escherichia coli O157:H7 str. EC508
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
T
SV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
TVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
SA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|478008.5.peg.1832
Escherichia coli O157:H7 str. EC869
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
T
SV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
TVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
SA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|637388.3.peg.2969
Escherichia coli O157:H7 str. FRIK2000
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
T
SV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
TVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
SA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|570506.3.peg.4761
Escherichia coli O157:H7 str. FRIK966
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
T
SV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
TVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
SA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|386585.9.peg.4856
Escherichia coli O157:H7 str. Sakai
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
T
SV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
TVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
SA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|544404.4.peg.4841
Escherichia coli O157:H7 str. TW14359
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
T
SV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
TVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
SA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|502346.5.peg.1966
Escherichia coli O157:H7 str. TW14588
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
T
SV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
TVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
SA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|701177.3.peg.4523
Escherichia coli O55:H7 str. CB9615
MSRFLICSFALV
L
L
Y
P
AG
IDMYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
IMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKS
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
TVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
SA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPV
T
AHEEIHHHA
fig|439855.10.peg.4219
Escherichia coli SMS-3-5
MYL
V
GLP
R
IAA
D
L
N
A
SEAQ
LHIAFS
V
YL
A
G
M
A
A
A
M
L
FA
G
K
VAD
RS
GRK
-
PV
A
I
P
G
A
ALFI
I
ASV
F
CSLA
E
T
S
TL
FLA
G
RF
L
QGLGAG
CC
YVV
AF
AI
L
RD
T
L
DDRRR
AK
VL
SLLN
G
I
T
C
I
I
PVLAPVLG
-
H
L
IM
LK
F
P
W
QS
LFW
T
MA
TMG
I
AV
L
MLS
LF
I
LKETRP
AAPAA
S
DKP
RE
N
----
SESLL
NR
F
FLS
RV
V
I
TT
L
S
V
SVILTFV
N
TSPVLL
M
EI
M
GF
E
R
GE
Y
AT
----------
I
M
ALT
-A
GV
S
M
TVS
F
S
TP
F
-
-
-
-
-
AL
G
IFK
P
RT
L--M
I
T
S
QVL
F
L
A
A
----
G
I
T
L
AVS
PSHAVSLFGI
TLI
CAG
F
S
VGF
GV--
-
-
-
-
--
---
AMS
QA
L
GP
F
SLR
AG
V
ASST
L
G
IAQ
V
CG
S
S
L
WIW
L
AAV
V
GI
GA
-
---
W
N
M
LIG
I
---
LI
AC
S
I
V
SLL
LI
M
FVAPGRPVAAHEEIHHHA
fig|656440.3.peg.2171
Escherichia coli TA206 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IL
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
I
S
S
I
L
FC
L
YAS
fig|444454.5.peg.119
Escherichia coli O157:H7 str. EC4024 (1-378/380)
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
A
Q
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
FY
GP
M
AD
SL
GRK
-
PV
I
L
G
G
T
L
I
F
A
A
A
A
V
A
C
A
LA
Q
S
I
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
V
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
L
V
AP
M
V
G
-
G
A
V
L
VW
F
S
W
HA
I
FW
I
L
A
IAA
L
LA
S
VMI
F
V
F
I
D
ET
L
P
VERRQ
K
FHV
R
T
T
L
GNF
ASLFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
E
L
N
HV
S
P
QH
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
I
N
SRF
V
R
R
V
G
AL
N
M
F
R
A
GL
WIQF
V
M
A
IWL
VL
S
A
----
L
L
G
V
GFW
----------
A
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
S
M
AT
F
NTA
W
P
M
LWA
I
---
AL
-
C
A
T
C
S
I
L
FY
L
YAS
RP
R
KT
A
fig|749527.3.peg.177
Escherichia coli MS 21-1 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
TMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|478007.5.peg.4969
Escherichia coli O157:H7 str. EC508 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
M
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|656437.3.peg.2455
Escherichia coli TA143 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
A
GL
WIQF
M
V
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|656444.3.peg.3176
Escherichia coli TA280 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
A
GL
WIQF
M
V
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|216592.1.peg.2976
Escherichia coli 042 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|216592.3.peg.2524
Escherichia coli 042 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|562.371.peg.5044
Escherichia coli 1044A (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|562.373.peg.3933
Escherichia coli 1125A (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|562.372.peg.5585
Escherichia coli 1212A (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|562.374.peg.3333
Escherichia coli 536A (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|550676.3.peg.2482
Escherichia coli B185 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|550677.3.peg.1731
Escherichia coli B354 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|585057.4.peg.2418
Escherichia coli IAI39 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|585057.6.peg.2420
Escherichia coli IAI39 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|656417.3.peg.2858
Escherichia coli M605 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|656419.3.peg.2942
Escherichia coli M718 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|679205.4.peg.4646
Escherichia coli MS 124-1 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|749533.3.peg.324
Escherichia coli MS 84-1 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|83334.1.peg.3068
Escherichia coli O157:H7 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|155864.1.peg.3073
Escherichia coli O157:H7 EDL933 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|155864.8.peg.2965
Escherichia coli O157:H7 EDL933 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|444454.5.peg.1998
Escherichia coli O157:H7 str. EC4024 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|444449.5.peg.1460
Escherichia coli O157:H7 str. EC4042 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|444448.5.peg.221
Escherichia coli O157:H7 str. EC4045 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|444453.5.peg.1567
Escherichia coli O157:H7 str. EC4076 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|444452.5.peg.2586
Escherichia coli O157:H7 str. EC4113 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|444450.8.peg.3311
Escherichia coli O157:H7 str. EC4115 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|444451.5.peg.815
Escherichia coli O157:H7 str. EC4196 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|444447.5.peg.355
Escherichia coli O157:H7 str. EC4206 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|478006.5.peg.4211
Escherichia coli O157:H7 str. EC4501 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|478008.5.peg.4114
Escherichia coli O157:H7 str. EC869 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|637388.3.peg.399
Escherichia coli O157:H7 str. FRIK2000 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|570506.3.peg.4933
Escherichia coli O157:H7 str. FRIK966 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|386585.9.peg.3206
Escherichia coli O157:H7 str. Sakai (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|544404.4.peg.3114
Escherichia coli O157:H7 str. TW14359 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|502346.5.peg.4309
Escherichia coli O157:H7 str. TW14588 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|701177.3.peg.2749
Escherichia coli O55:H7 str. CB9615 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|439855.10.peg.2499
Escherichia coli SMS-3-5 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|431946.3.peg.1321
Escherichia coli SE15 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
I
H
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GT
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
I
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|749531.3.peg.1959
Escherichia coli MS 69-1 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
G
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|550677.3.peg.2755
Escherichia coli B354 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
N
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
I
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|749531.3.peg.292
Escherichia coli MS 69-1 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
N
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
I
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|656379.3.peg.2719
Escherichia coli FVEC1302 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|656380.3.peg.2278
Escherichia coli FVEC1412 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|749549.3.peg.1844
Escherichia coli MS 198-1 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|585056.7.peg.2701
Escherichia coli UMN026 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|525281.3.peg.126
Escherichia coli 83972 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
I
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|655817.3.peg.1655
Escherichia coli ABU 83972 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
I
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|199310.1.peg.1713
Escherichia coli CFT073 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
I
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|199310.4.peg.1642
Escherichia coli CFT073 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
I
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|749546.3.peg.268
Escherichia coli MS 185-1 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
I
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|749527.3.peg.413
Escherichia coli MS 21-1 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
I
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|749528.3.peg.174
Escherichia coli MS 45-1 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
I
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|656444.3.peg.2025
Escherichia coli TA280 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
I
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|656393.3.peg.2065
Escherichia coli H299 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
I
R
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
I
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|670897.3.peg.2456
Escherichia coli 2362-75 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
V
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|362663.8.peg.1358
Escherichia coli 536 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
V
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|362663.9.peg.1358
Escherichia coli 536 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
V
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|405955.13.peg.1408
Escherichia coli APEC O1 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
V
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|405955.9.peg.1158
Escherichia coli APEC O1 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
V
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|216593.1.peg.1929
Escherichia coli E2348/69 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
V
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|340197.3.peg.1123
Escherichia coli F11 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
V
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|340197.5.peg.1184
Escherichia coli F11 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
V
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|714962.3.peg.1534
Escherichia coli IHE3034 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
V
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|749550.3.peg.64
Escherichia coli MS 200-1 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
V
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|753642.3.peg.1819
Escherichia coli NC101 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
I
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
V
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|574521.7.peg.1511
Escherichia coli O127:H6 str. E2348/69 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
V
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|685038.3.peg.1337
Escherichia coli O83:H1 str. NRG 857C (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
V
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|585035.6.peg.1425
Escherichia coli S88 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
V
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|869729.3.peg.2188
Escherichia coli UM146 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
V
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|364106.7.peg.1605
Escherichia coli UTI89 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
V
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|364106.8.peg.1605
Escherichia coli UTI89 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
V
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|562.376.peg.3161
Escherichia coli WV_060327 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
V
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|749532.3.peg.3467
Escherichia coli MS 78-1 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
VT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
S
S
S
I
L
FC
L
YAS
fig|656440.3.peg.1205
Escherichia coli TA206 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RGVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
V
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
S
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|585057.4.peg.1714
Escherichia coli IAI39 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
T
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|585057.6.peg.1714
Escherichia coli IAI39 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
T
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|439855.10.peg.1992
Escherichia coli SMS-3-5 (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
LL
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
T
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|585397.7.peg.1509
Escherichia coli ED1a (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
M
L
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
V
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|585397.9.peg.1503
Escherichia coli ED1a (7-380/387)
SWALILGL
L
A
G
I
G
P
MC
T
D
L
YLP
A
LP
E
MSE
QL
A
A
TTTI
TQ
L
TLT
A
S
L
I
G
L
G
V
G
QL
LF
GP
L
S
D
KI
GRK
R
P
L
I
L
-
S
L
L
LFI
V
S
S
I
L
C
ATT
N
N
I
YW
L
V
V
W
RF
I
QG
IAGA
GG
S
V
L
SR
S
I
A
RD
K
Y
QGVTL
T
Q
FF
A
M
L
M
T
V
N
G
L
APVL
S
PVLG
-
G
Y
I
V
ST
F
D
W
RT
LFW
V
MA
EIS
T
VL
L
LGC
L
L
F
IN
ET
L
P
ENKRG
S
SLL
LT
G
----
RSVVQ
NRRF
MR
FC
LI
QS
F
M
L
AG
L
F
A
Y
I
G
S
S
SFV
L
Q
KE
F
GF
S
P
MQ
F
SL
----------
V
F
G
L
N
GI
G
L
I
I
ASW
I
F
SR
L
A
R
R
I
N
A
M
T
L
LR
G
GL
IAAI
L
C
A
LLT
VL
C
A
----
W
V
Q
L
PIP
----------
A
L
V
ALF
F
T
IA
F
CSGI
G
T
V
G
--
GAE
AMS
AV
G
TQ
-
--E
S
GTAS
AL
M
G
MSM
F
VF
G
G
I
---
A
A
PL
S
GI
GG
-
ETL
L
K
M
SLA
I
---
TV
-
C
Y
T
L
A
LL
VA
L
fig|1040638.4.peg.3265
Escherichia coli O104:H4 str. LB226692 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|6666666.5357.peg.532
Escherichia coli TY-2482 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|358709.5.peg.631
Escherichia coli 101-1 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|670888.3.peg.4096
Escherichia coli 1827-70 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|344610.3.peg.1741
Escherichia coli 53638 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|344610.7.peg.4247
Escherichia coli 53638 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|585055.6.peg.2471
Escherichia coli 55989 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|585055.8.peg.2477
Escherichia coli 55989 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|481805.3.peg.1570
Escherichia coli ATCC 8739 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|481805.6.peg.1562
Escherichia coli ATCC 8739 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|413997.3.peg.2206
Escherichia coli B str. REL606 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|340184.3.peg.423
Escherichia coli B7A (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
T
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|340184.6.peg.441
Escherichia coli B7A (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
T
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|511693.5.peg.2217
Escherichia coli BL21 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|469008.4.peg.1517
Escherichia coli BL21(DE3) (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|595496.3.peg.2152
Escherichia coli BW2952 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|536056.3.peg.1550
Escherichia coli DH1 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|331111.12.peg.2767
Escherichia coli E24377A (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|331111.3.peg.223
Escherichia coli E24377A (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|656414.3.peg.2555
Escherichia coli H736 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|331112.3.peg.2178
Escherichia coli HS (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|331112.6.peg.2277
Escherichia coli HS (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|83333.1.peg.2157
Escherichia coli K12 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|679207.4.peg.4058
Escherichia coli MS 107-1 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|749537.3.peg.2471
Escherichia coli MS 115-1 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|749538.3.peg.3250
Escherichia coli MS 116-1 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|679204.3.peg.218
Escherichia coli MS 145-7 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
T
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|749540.3.peg.836
Escherichia coli MS 146-1 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|749548.3.peg.2185
Escherichia coli MS 196-1 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|316407.3.peg.2116
Escherichia coli W3110 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|316385.5.peg.2305
Escherichia coli str. K-12 substr. DH10B (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|316385.7.peg.2360
Escherichia coli str. K-12 substr. DH10B (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|511145.12.peg.2270
Escherichia coli str. K-12 substr. MG1655 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|511145.6.peg.2254
Escherichia coli str. K-12 substr. MG1655 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|585034.4.peg.2234
Escherichia coli IAI1 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FY
L
YAS
fig|585034.5.peg.2231
Escherichia coli IAI1 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FY
L
YAS
fig|595495.4.peg.251
Escherichia coli KO11 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FY
L
YAS
fig|566546.3.peg.1446
Escherichia coli W (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FY
L
YAS
fig|566546.4.peg.2364
Escherichia coli W (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FY
L
YAS
fig|749547.3.peg.2619
Escherichia coli MS 187-1 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|478005.5.peg.1847
Escherichia coli O157:H7 str. EC4486 (2-370/375)
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
Q
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
VAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|656408.3.peg.2433
Escherichia coli H591 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AALFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
ICS
I
---
AF
-
C
A
S
S
S
I
L
FC
L
YAS
fig|316401.4.peg.2653
Escherichia coli ETEC H10407 (18-391/396)
L
A
M
L
M
P
LS
IDMYLP
A
LP
V
I
S
AQ
F
G
V
PAGS
TQ
M
TL
S
T
Y
I
L
G
F
A
L
G
QL
IY
GP
M
AD
SF
GRK
-
PV
V
L
G
G
T
LV
F
A
A
A
A
V
A
C
A
LA
N
TI
DQ
L
I
V
M
RF
F
H
GL
A
A
A
AA
S
VV
IN
A
L
M
RD
I
Y
PKEEF
SR
MM
S
FVM
L
VT
T
IAP
LM
AP
IV
G
-
G
W
V
L
VW
L
S
W
HY
I
FW
I
L
A
LAA
I
LA
S
AMI
F
F
L
I
KET
L
P
PERRQ
P
FHI
R
T
T
IGNF
AVLFR
HK
R
V
LS
YM
L
A
SG
FS
F
AG
M
F
S
F
L
S
A
G
P
FVY
I
EI
N
HV
A
P
EN
F
GY
----------
Y
FAL
N
IV
FL
F
V
MTI
F
N
SRF
V
R
R
I
G
AL
N
M
F
R
S
GL
WIQF
I
M
A
AWM
V
I
S
A
----
L
L
G
L
GFW
----------
S
L
V
---
-
-
VG
V
AAFV
G
C
V
S
MV
SSN
AM
A
VI
L
DE
F
PHM
AGTASS
L
A
G
TFR
F
GI
G
A
I
---
V
G
A
L
L
SL
AT
F
NSA
W
P
M
IWS
I
---
AF
-
C
A
T
S
S
I
L
FC
L
YAS
fig|83333.1.peg.1646
Escherichia coli K12 (6-387/403)
RFL
V
W
L
AG
L
S
V
L
G
F
LA
T
DMYLP
A
FA
A
I
Q
A
D
L
Q
T
PASA
V
SA
S
L
S
L
F
L
A
G
F
A
A
AQL
LW
GP
L
S
D
RY
GRK
-
PV
L
L
I
G
L
T
I
F
A
L
G
S
L
G
MLWV
E
N
A
AT
L
L
V
L
RF
V
Q
A
V
G
VC
AA
A
V
I
WQ
A
L
V
T
D
Y
Y
PSQKV
N
R
IF
A
A
I
M
P
L
V
G
L
S
P
A
LAP
L
LG
-
S
W
LL
VH
F
S
W
QA
I
F
A
T
L
F
AIT
V
VL
I
LPI
F
W
L
KPT
T
K
A
R----
-
NNS
QD
G
-
LT
F
TDLLR
S
K
T
Y
RG
NV
LI
YA
AC
S
A
SF
F
A
WL
T
G
SP
F
I
-
-
--
-
-L
S
E
MG
Y
SP
AVIGLSYVPQ
T
I
A
FL
IG
G
Y
G
C
RAA
L
Q
KWQ
-
-
-
-
-
--
-
-G
K
Q
L
L
PWLL
V
L
F
AVS
V
I
A
T
----
W
A
A
G
FIS
----------
H
V
S
LVE
I
L
I
P
F
CVMA
I
A
N
G
AI
YPI
V
V
A
QA
L
RP
F
PHA
T
G
R
A
A
AL
Q
N
TLQ
L
G-
-
-
-
---
L
CF
L
A
SL
VV
S
---
W
L
I
SIS
T
--
P
LL
TT
T
S
V
M
L
S
TV
M
L
VA
L
G
YM
M
QRC
EE
V
fig|656444.3.peg.1398
Escherichia coli TA280 (32-397/410)
G
N
DM
IQ
PG
M
L
A
V
V
E
Q
Y
Q
A
GIDW
V
PT
S
M
T
A
YL
A
G
G
M
F
L
Q
W
LL
GP
L
S
D
RI
GR
R
-
PV
M
L
A
G
V
VW
FI
V
TC
L
A
IL
LA
Q
N
I
EQ
F
TL
L
RF
L
QG
I
SLC
FI
GA
V
GY
A
A
I
QE
S
F
EEAVC
I
K
IT
A
L
M
A
N
V
A
L
IAP
L
L
G
P
L
V
G
AA
W
I
H
V-
L
P
W
EG
M
F
V
L
F
A
ALA
A
IS
F
FGL
QR
A
M
P
ET
AT
RIGEK
L
SLK
EL
G
-
RDY
KLVLK
N
G
RF
VA
GA
L
A
LG
F
V
S
LP
L
L
A
WI
A
Q
SP
III
I
TG
E
QL
S
S
YE
Y
--
---
GLLQVP
-
I
F
G
AL
IA
G
N
L
L
LAR
L
T
SR
R
T
V
R
S
L
I
I
M
GGW
P
IM
IGLF
V
A
A
AAT
V
I
S
S
HAYL
W
M
T
A
GLS
----------
---
---
-
I
Y
A
F
GI-G
L
A
N
A
GL
---
-
V
R
LT
L
FA
S
DMS
K
GT
V
S
A
A
M
G
MLQ
M
--
-
-
-
---
L
IFT
V
GI
EI
S
KHA
W
L
N
GGN
GLFN
LF
NL
V
N
G
I
L
W
LL
L
M
V
I
fig|656437.3.peg.928
Escherichia coli TA143 (32-397/410)
G
N
DM
IQ
PG
M
L
A
V
V
E
Q
Y
Q
A
GIDW
V
PT
S
M
T
A
YL
A
G
G
M
F
L
Q
W
LL
GP
L
S
D
RI
GR
R
-
PV
M
L
A
G
V
VW
FI
I
TC
L
A
IL
LA
Q
N
I
EQ
F
TL
L
RF
L
QG
I
SLC
FI
GA
V
GY
A
A
I
QE
S
F
EEAVC
I
K
IT
A
L
M
A
N
V
A
L
IAP
L
L
G
P
L
V
G
AA
W
I
H
V-
L
P
W
EG
M
F
V
L
F
A
ALA
A
IS
F
FGL
QR
A
M
P
ET
AT
RIGEK
L
SLK
EL
G
-
RDY
KLVLK
N
G
RF
VA
GA
L
A
LG
F
V
S
LP
L
L
A
WI
A
Q
SP
III
I
TG
E
QL
S
S
YE
Y
--
---
GLLQVP
-
I
F
G
AL
IA
G
N
L
L
LAR
L
T
SR
R
T
V
R
S
L
I
I
M
GGW
P
IM
IGLL
V
A
A
AAT
V
I
S
S
HAYL
W
M
T
A
GLS
----------
---
---
-
L
Y
A
F
GI-G
L
A
N
A
GL
---
-
V
R
LT
L
FA
S
DMS
K
GT
V
S
A
A
M
G
MLQ
M
--
-
-
-
---
L
IFT
V
GI
EI
S
KHA
W
L
N
GGN
GLFN
LF
NL
V
N
G
I
L
W
LL
L
M
V
I
fig|656379.3.peg.1686
Escherichia coli FVEC1302 (32-397/410)
G
N
DM
IQ
PG
M
L
A
V
V
E
Q
Y
Q
A
GIDW
V
PT
S
M
T
A
YL
A
G
G
M
F
L
Q
W
LL
GP
L
S
D
RI
GR
R
-
PV
M
L
A
G
V
VW
FI
I
TC
L
A
IL
LA
Q
N
I
EQ
F
TL
L
RF
L
QG
I
SLC
FI
GA
V
GY
A
A
I
QE
S
F
EEAVC
I
K
IT
A
L
M
A
N
V
A
L
IAP
L
L
G
P
L
V
G
AA
W
I
H
V-
L
P
W
EG
M
F
V
L
F
A
ALA
A
IS
F
FGL
QR
A
M
P
ET
AT
RIGEK
L
SLK
EL
G
-
RDY
KLVLK
N
G
RF
VA
GA
L
A
LG
F
V
S
LP
L
L
A
WI
A
Q
SP
III
I
TG
E
QL
S
S
YE
Y
--
---
GLLQVP
-
I
F
G
AL
IA
G
N
L
L
LAR
L
T
SR
R
T
V
R
S
L
I
I
M
GGW
P
IM
IGLL
V
A
A
AAT
V
I
S
S
HAYL
W
M
A
A
GLS
----------
---
---
-
L
Y
A
F
GI-G
L
A
N
A
GL
---
-
V
R
LT
L
FA
S
DMS
K
GT
V
S
A
A
M
G
MLQ
M
--
-
-
-
---
L
IFT
V
GI
EI
S
KHA
W
L
N
GGN
GLFN
LF
NL
V
N
G
I
L
W
LL
L
M
V
I
fig|656380.3.peg.1513
Escherichia coli FVEC1412 (32-397/410)
G
N
DM
IQ
PG
M
L
A
V
V
E
Q
Y
Q
A
GIDW
V
PT
S
M
T
A
YL
A
G
G
M
F
L
Q
W
LL
GP
L
S
D
RI
GR
R
-
PV
M
L
A
G
V
VW
FI
I
TC
L
A
IL
LA
Q
N
I
EQ
F
TL
L
RF
L
QG
I
SLC
FI
GA
V
GY
A
A
I
QE
S
F
EEAVC
I
K
IT
A
L
M
A
N
V
A
L
IAP
L
L
G
P
L
V
G
AA
W
I
H
V-
L
P
W
EG
M
F
V
L
F
A
ALA
A
IS
F
FGL
QR
A
M
P
ET
AT
RIGEK
L
SLK
EL
G
-
RDY
KLVLK
N
G
RF
VA
GA
L
A
LG
F
V
S
LP
L
L
A
WI
A
Q
SP
III
I
TG
E
QL
S
S
YE
Y
--
---
GLLQVP
-
I
F
G
AL
IA
G
N
L
L
LAR
L
T
SR
R
T
V
R
S
L
I
I
M
GGW
P
IM
IGLL
V
A
A
AAT
V
I
S
S
HAYL
W
M
A
A
GLS
----------
---
---
-
L
Y
A
F
GI-G
L
A
N
A
GL
---
-
V
R
LT
L
FA
S
DMS
K
GT
V
S
A
A
M
G
MLQ
M
--
-
-
-
---
L
IFT
V
GI
EI
S
KHA
W
L
N
GGN
GLFN
LF
NL
V
N
G
I
L
W
LL
L
M
V
I
fig|585056.7.peg.1225
Escherichia coli UMN026 (32-397/410)
G
N
DM
IQ
PG
M
L
A
V
V
E
Q
Y
Q
A
GIDW
V
PT
S
M
T
A
YL
A
G
G
M
F
L
Q
W
LL
GP
L
S
D
RI
GR
R
-
PV
M
L
A
G
V
VW
FI
I
TC
L
A
IL
LA
Q
N
I
EQ
F
TL
L
RF
L
QG
I
SLC
FI
GA
V
GY
A
A
I
QE
S
F
EEAVC
I
K
IT
A
L
M
A
N
V
A
L
IAP
L
L
G
P
L
V
G
AA
W
I
H
V-
L
P
W
EG
M
F
V
L
F
A
ALA
A
IS
F
FGL
QR
A
M
P
ET
AT
RIGEK
L
SLK
EL
G
-
RDY
KLVLK
N
G
RF
VA
GA
L
A
LG
F
V
S
LP
L
L
A
WI
A
Q
SP
III
I
TG
E
QL
S
S
YE
Y
--
---
GLLQVP
-
I
F
G
AL
IA
G
N
L
L
LAR
L
T
SR
R
T
V
R
S
L
I
I
M
GGW
P
IM
IGLL
V
A
A
AAT
V
I
S
S
HAYL
W
M
A
A
GLS
----------
---
---
-
L
Y
A
F
GI-G
L
A
N
A
GL
---
-
V
R
LT
L
FA
S
DMS
K
GT
V
S
A
A
M
G
MLQ
M
--
-
-
-
---
L
IFT
V
GI
EI
S
KHA
W
L
N
GGN
GLFN
LF
NL
V
N
G
I
L
W
LL
L
M
V
I
fig|585057.4.peg.870
Escherichia coli IAI39 (32-397/410)
G
N
DM
IQ
PG
M
L
A
V
V
E
Q
Y
Q
A
GIDW
V
PT
S
M
T
A
YL
A
G
G
M
F
L
Q
W
LL
GP
L
S
D
RI
GR
R
-
PV
M
L
A
G
V
VW
FI
V
TC
L
A
IL
LA
Q
N
I
EQ
F
TL
L
RF
L
QG
I
SLC
FI
GA
V
GY
A
A
I
QE
S
F
EEAVC
I
K
IT
A
L
M
A
N
V
A
L
IAP
L
L
G
P
L
V
G
AA
W
I
H
V-
L
P
W
EG
M
F
V
L
F
A
ALA
A
IS
F
FGL
QR
A
M
P
ET
AT
RIGEK
L
SLK
EL
G
-
RDY
KLVLK
N
G
RF
VA
GA
L
A
LG
F
V
S
LP
L
L
A
WI
A
Q
SP
III
I
TG
E
QL
S
S
YE
Y
--
---
GLLQVP
-
I
F
G
AL
IA
G
N
L
L
LAR
L
T
SR
R
T
V
R
S
L
I
I
M
GGW
P
IM
IGLL
V
A
A
AAT
V
I
S
S
HAYL
W
M
T
A
GLS
----------
---
---
-
L
Y
A
F
GI-G
L
A
N
A
GL
---
-
V
R
LT
L
FA
S
DMS
K
GT
V
S
A
A
M
G
MLQ
M
--
-
-
-
---
L
IFT
V
GI
EI
S
KHA
W
L
N
GGN
GLFN
LF
NL
V
N
G
I
L
W
LL
L
M
V
I
fig|585057.6.peg.866
Escherichia coli IAI39 (32-397/410)
G
N
DM
IQ
PG
M
L
A
V
V
E
Q
Y
Q
A
GIDW
V
PT
S
M
T
A
YL
A
G
G
M
F
L
Q
W
LL
GP
L
S
D
RI
GR
R
-
PV
M
L
A
G
V
VW
FI
V
TC
L
A
IL
LA
Q
N
I
EQ
F
TL
L
RF
L
QG
I
SLC
FI
GA
V
GY
A
A
I
QE
S
F
EEAVC
I
K
IT
A
L
M
A
N
V
A
L
IAP
L
L
G
P
L
V
G
AA
W
I
H
V-
L
P
W
EG
M
F
V
L
F
A
ALA
A
IS
F
FGL
QR
A
M
P
ET
AT
RIGEK
L
SLK
EL
G
-
RDY
KLVLK
N
G
RF
VA
GA
L
A
LG
F
V
S
LP
L
L
A
WI
A
Q
SP
III
I
TG
E
QL
S
S
YE
Y
--
---
GLLQVP
-
I
F
G
AL
IA
G
N
L
L
LAR
L
T
SR
R
T
V
R
S
L
I
I
M
GGW
P
IM
IGLL
V
A
A
AAT
V
I
S
S
HAYL
W
M
T
A
GLS
----------
---
---
-
L
Y
A
F
GI-G
L
A
N
A
GL
---
-
V
R
LT
L
FA
S
DMS
K
GT
V
S
A
A
M
G
MLQ
M
--
-
-
-
---
L
IFT
V
GI
EI
S
KHA
W
L
N
GGN
GLFN
LF
NL
V
N
G
I
L
W
LL
L
M
V
I
fig|749527.3.peg.4421
Escherichia coli MS 21-1 (32-397/410)
G
N
DM
IQ
PG
M
L
A
V
V
E
Q
Y
Q
A
GIDW
V
PT
S
M
T
A
YL
A
G
G
M
F
L
Q
W
LL
GP
L
S
D
RI
GR
R
-
PV
M
L
A
G
V
VW
FI
V
TC
L
A
IL
LA
Q
N
I
EQ
F
TL
L
RF
L
QG
I
SLC
FI
GA
V
GY
A
A
I
QE
S
F
EEAVC
I
K
IT
A
L
M
A
N
V
A
L
IAP
L
L
G
P
L
V
G
AA
W
I
H
V-
L
P
W
EG
M
F
V
L
F
A
ALA
A
IS
F
FGL
QR
A
M
P
ET
AT
RIGEK
L
SLK
EL
G
-
RDY
KLVLK
N
G
RF
VA
GA
L
A
LG
F
V
S
LP
L
L
A
WI
A
Q
SP
III
I
TG
E
QL
S
S
YE
Y
--
---
GLLQVP
-
I
F
G
AL
IA
G
N
L
L
LAR
L
T
SR
R
T
V
R
S
L
I
I
M
GGW
P
IM
IGLL
V
A
A
AAT
V
I
S
S
HAYL
W
M
T
A
GLS
----------
---
---
-
L
Y
A
F
GI-G
L
A
N
A
GL
---
-
V
R
LT
L
FA
S
DMS
K
GT
V
S
A
A
M
G
MLQ
M
--
-
-
-
---
L
IFT
V
GI
EI
S
KHA
W
L
N
GGN
GLFN
LF
NL
V
N
G
I
L
W
LL
L
M
V
I
fig|439855.10.peg.1026
Escherichia coli SMS-3-5 (32-397/410)
G
N
DM
IQ
PG
M
L
A
V
V
E
Q
Y
Q
A
GIDW
V
PT
S
M
T
A
YL
A
G
G
M
F
L
Q
W
LL
GP
L
S
D
RI
GR
R
-
PV
M
L
A
G
V
VW
FI
V
TC
L
A
IL
LA
Q
N
I
EQ
F
TL
L
RF
L
QG
I
SLC
FI
GA
V
GY
A
A
I
QE
S
F
EEAVC
I
K
IT
A
L
M
A
N
V
A
L
IAP
L
L
G
P
L
V
G
AA
W
I
H
V-
L
P
W
EG
M
F
V
L
F
A
ALA
A
IS
F
FGL
QR
A
M
P
ET
AT
RIGEK
L
SLK
EL
G
-
RDY
KLVLK
N
G
RF
VA
GA
L
A
LG
F
V
S
LP
L
L
A
WI
A
Q
SP
III
I
TG
E
QL
S
S
YE
Y
--
---
GLLQVP
-
I
F
G
AL
IA
G
N
L
L
LAR
L
T
SR
R
T
V
R
S
L
I
I
M
GGW
P
IM
IGLL
V
A
A
AAT
V
I
S
S
HAYL
W
M
T
A
GLS
----------
---
---
-
L
Y
A
F
GI-G
L
A
N
A
GL
---
-
V
R
LT
L
FA
S
DMS
K
GT
V
S
A
A
M
G
MLQ
M
--
-
-
-
---
L
IFT
V
GI
EI
S
KHA
W
L
N
GGN
GLFN
LF
NL
V
N
G
I
L
W
LL
L
M
V
I
fig|550677.3.peg.2113
Escherichia coli B354 (32-397/410)
G
N
DM
IQ
PG
M
L
A
V
V
E
Q
Y
Q
A
GIDW
V
PT
S
M
T
A
YL
A
G
G
M
F
L
Q
W
LL
GP
L
S
D
RI
GR
R
-
PV
M
L
A
G
V
VW
FI
I
TC
L
A
IL
LA
Q
N
I
EQ
F
TL
L
RF
L
QG
I
SLC
FI
GA
V
GY
A
A
I
QE
S
F
EEAVC
I
K
IT
A
L
M
A
N
V
A
L
IAP
L
L
G
P
L
V
G
AA
W
I
H
V-
L
P
W
EG
M
F
V
L
F
A
ALA
A
IS
F
FGL
QR
A
M
P
ET
AT
RIGEK
L
SLK
EL
G
-
RDY
KLVLK
N
G
RF
VA
GA
L
A
LG
F
V
S
LP
L
L
A
WI
A
Q
SP
III
I
TG
E
QL
S
S
YE
Y
--
---
GLLQVP
-
I
F
G
AL
IA
G
N
L
L
LAR
L
T
SR
R
T
V
R
S
L
I
I
M
GGW
P
IM
IGLL
V
A
A
AAT
V
I
S
S
HAYL
W
M
T
A
GLS
----------
---
---
-
I
Y
A
F
GI-G
L
A
N
A
GL
---
-
V
R
LT
L
FA
S
DMS
K
GT
V
S
A
A
M
G
MLQ
M
--
-
-
-
---
L
IFT
V
GI
EI
S
KHA
W
L
N
GGN
GLFN
LF
NL
V
N
G
I
L
W
LL
L
M
V
I
fig|749549.3.peg.137
Escherichia coli MS 198-1 (32-397/410)
G
N
DM
IQ
PG
M
L
A
V
V
E
Q
Y
Q
A
GIDW
V
PT
S
M
T
A
YL
A
G
G
M
F
L
Q
W
LL
GP
L
S
D
RI
GR
R
-
PV
M
L
A
G
V
VG
FI
I
TC
L
A
IL
LA
Q
N
I
EQ
F
TL
L
RF
L
QG
I
SLC
FI
GA
V
GY
A
A
I
QE
S
F
EEAVC
I
K
IT
A
L
M
A
N
V
A
L
IAP
L
L
G
P
L
V
G
AA
W
I
H
V-
L
P
W
EG
M
F
V
L
F
A
ALA
A
IS
F
FGL
QR
A
M
P
ET
AT
RIGEK
L
SLK
EL
G
-
RDY
KLVLK
N
G
RF
VA
GA
L
A
LG
F
V
S
LP
L
L
A
WI
A
Q
SP
III
I
TG
E
QL
S
S
YE
Y
--
---
GLLQVP
-
I
F
G
AL
IA
G
N
L
L
LAR
L
T
SR
R
T
V
R
S
L
I
I
M
GGW
P
IM
IGLL
V
A
A
AAT
V
I
S
S
HAYL
W
M
A
A
GLS
----------
---
---
-
L
Y
A
F
GI-G
L
A
N
A
GL
---
-
V
R
LT
L
FA
S
DMS
K
GT
V
S
A
A
M
G
MLQ
M
--
-
-
-
---
L
IFT
V
GI
EI
S
KHA
W
L
N
GGN
GLFN
LF
NL
V
N
G
I
L
W
LL
L
M
V
I
Consen1
Primary consensus
MSrflicsfaLv
l
P
iDmYLpgLP
iaaql
a
lhiafs
yl
G
a
aqL
GpvaD
GRK
-
Pv
l
g
alFi
asv
Csla
ti
fla
RF
qGlgag
yVv
ai
RD
l
ak
slln
vt
iaPvlaPvlG
-
h
im
f
W
lFW
mA
i
l
lf
lkETrP
s
re
----
nrrfls
li
fs
sviltfv
tspvll
ei
gf
r
y
----------
faLt
gv
m
f
srf
-
r
-
Al
ifk
rt
i
a
vl
A
----
i
L
----------
tLi
f
vgf
-
-
--
AMs
l
f
aGtASst
G
v
s
l
---
aav
gi
-
w
M
I
---
aC
i
slL
lfvaPGRPVaAHEEIHHHA
Consen2
Secondary consensus
swalilgl
a
i
t
l
va
msedf
v
tq
tlt
si
g
gm
k
s
r
l
i
s
lv
a
ai
att
ns
l
v
h
iaga
s
l
sl
y
afvm
in
li
lms
iv
g
v
l
i
l
t
s
fl
in
l
p
lt
ignf
hkfvmr
va
lm
ag
f
y
gsfvy
ke
hv
p
f
mg
n
fl
i
tpl
r
-
i
m
lr
gl
l
s
fi
pshavslfgi
v
-
iav
g
v
mv
a
g
-
s
v
al
f
g
iwiw
gpl
sl
f
l
-
t
ai
myas
t
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character