fig|749531.3.peg.334
Escherichia coli MS 69-1
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|562.371.peg.3055
Escherichia coli 1044A
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|562.373.peg.983
Escherichia coli 1125A
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|562.372.peg.3941
Escherichia coli 1212A
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|562.374.peg.2031
Escherichia coli 536A
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|83334.1.peg.4582
Escherichia coli O157:H7
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|444454.5.peg.3702
Escherichia coli O157:H7 str. EC4024
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|444449.5.peg.3157
Escherichia coli O157:H7 str. EC4042
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|444448.5.peg.1913
Escherichia coli O157:H7 str. EC4045
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|444453.5.peg.1442
Escherichia coli O157:H7 str. EC4076
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|444452.5.peg.1656
Escherichia coli O157:H7 str. EC4113
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|444450.8.peg.4994
Escherichia coli O157:H7 str. EC4115
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|444451.5.peg.72
Escherichia coli O157:H7 str. EC4196
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|444447.5.peg.2076
Escherichia coli O157:H7 str. EC4206
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|478004.5.peg.469
Escherichia coli O157:H7 str. EC4401
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|478005.5.peg.404
Escherichia coli O157:H7 str. EC4486
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|478006.5.peg.454
Escherichia coli O157:H7 str. EC4501
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|478007.5.peg.1513
Escherichia coli O157:H7 str. EC508
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|478008.5.peg.976
Escherichia coli O157:H7 str. EC869
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|637388.3.peg.2932
Escherichia coli O157:H7 str. FRIK2000
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|570506.3.peg.4725
Escherichia coli O157:H7 str. FRIK966
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|386585.9.peg.4819
Escherichia coli O157:H7 str. Sakai
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|544404.4.peg.4805
Escherichia coli O157:H7 str. TW14359
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|502346.5.peg.2002
Escherichia coli O157:H7 str. TW14588
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|701177.3.peg.4488
Escherichia coli O55:H7 str. CB9615
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|656444.3.peg.5010
Escherichia coli TA280
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|656437.3.peg.4151
Escherichia coli TA143
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NDEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|550677.3.peg.4260
Escherichia coli B354
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
I
H
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|155864.1.peg.4618
Escherichia coli O157:H7 EDL933
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
X
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|155864.8.peg.4577
Escherichia coli O157:H7 EDL933
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
X
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|585057.4.peg.4410
Escherichia coli IAI39
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
K
Y
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
EQP
G
M
TEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
THYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNET
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|585057.6.peg.4420
Escherichia coli IAI39
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
K
Y
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
EQP
G
M
TEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
THYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNET
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|656379.3.peg.4529
Escherichia coli FVEC1302
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
S
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLP
T
A
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|656380.3.peg.4813
Escherichia coli FVEC1412
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
S
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLP
T
A
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|749549.3.peg.1355
Escherichia coli MS 198-1
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
S
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLP
T
A
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|585056.7.peg.4374
Escherichia coli UMN026
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
S
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLP
T
A
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|216592.1.peg.1018
Escherichia coli 042
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
T
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
THYG
L
INA
V
AACVDD
S
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEV
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|216592.3.peg.4179
Escherichia coli 042
MASSGT
S
STRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AVAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
T
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
THYG
L
INA
V
AACVDD
S
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEV
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|1040638.4.peg.1555
Escherichia coli O104:H4 str. LB226692
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|6666666.5357.peg.677
Escherichia coli TY-2482
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|585055.6.peg.4171
Escherichia coli 55989
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|585055.8.peg.4174
Escherichia coli 55989
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|550672.3.peg.3741
Escherichia coli B088
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|344601.3.peg.2441
Escherichia coli B171
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|344601.5.peg.2544
Escherichia coli B171
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|340184.3.peg.898
Escherichia coli B7A
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|340184.6.peg.933
Escherichia coli B7A
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|340185.3.peg.2148
Escherichia coli E22
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|340185.4.peg.2277
Escherichia coli E22
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|562.375.peg.327
Escherichia coli EC4100B
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|585034.4.peg.3764
Escherichia coli IAI1
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|585034.5.peg.3761
Escherichia coli IAI1
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|595495.4.peg.2787
Escherichia coli KO11
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|679206.4.peg.2219
Escherichia coli MS 119-7
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|679205.4.peg.4732
Escherichia coli MS 124-1
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|679204.3.peg.2916
Escherichia coli MS 145-7
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|749545.3.peg.3403
Escherichia coli MS 182-1
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|749532.3.peg.429
Escherichia coli MS 78-1
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|749533.3.peg.1134
Escherichia coli MS 84-1
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|585395.4.peg.4694
Escherichia coli O103:H2 str. 12009
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|585396.4.peg.4656
Escherichia coli O111:H- str. 11128
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|656443.3.peg.4607
Escherichia coli TA271
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|566546.3.peg.3326
Escherichia coli W
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|566546.4.peg.3928
Escherichia coli W
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|331111.12.peg.4417
Escherichia coli E24377A
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|331111.3.peg.1819
Escherichia coli E24377A
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|573235.3.peg.5058
Escherichia coli O26:H11 str. 11368
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
D
V
FQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|679207.4.peg.100
Escherichia coli MS 107-1
MASSGTT
L
TRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|409438.11.peg.4129
Escherichia coli SE11
MASSGTT
L
TRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|656408.3.peg.4127
Escherichia coli H591
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMV
S
PGA
A
N
T
EMVGE
fig|358709.5.peg.89
Escherichia coli 101-1
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
S
L
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|344610.3.peg.1893
Escherichia coli 53638
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
S
L
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|344610.7.peg.2527
Escherichia coli 53638
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
S
L
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|413997.3.peg.3732
Escherichia coli B str. REL606
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
S
L
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|511693.5.peg.3751
Escherichia coli BL21
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
S
L
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|469008.4.peg.34
Escherichia coli BL21(DE3)
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
S
L
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|595496.3.peg.3675
Escherichia coli BW2952
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
S
L
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|536056.3.peg.34
Escherichia coli DH1
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
S
L
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|316401.4.peg.4497
Escherichia coli ETEC H10407
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
S
L
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|656414.3.peg.4194
Escherichia coli H736
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
S
L
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|83333.1.peg.3608
Escherichia coli K12
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
S
L
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|749538.3.peg.3194
Escherichia coli MS 116-1
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
S
L
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|749540.3.peg.959
Escherichia coli MS 146-1
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
S
L
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|749544.3.peg.1165
Escherichia coli MS 175-1
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
S
L
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|749547.3.peg.4317
Escherichia coli MS 187-1
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
S
L
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|749548.3.peg.4135
Escherichia coli MS 196-1
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
S
L
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|316407.3.peg.3457
Escherichia coli W3110
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
S
L
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|316385.5.peg.3806
Escherichia coli str. K-12 substr. DH10B
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
S
L
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|316385.7.peg.3892
Escherichia coli str. K-12 substr. DH10B
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
S
L
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|511145.12.peg.3793
Escherichia coli str. K-12 substr. MG1655
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
S
L
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|511145.6.peg.3775
Escherichia coli str. K-12 substr. MG1655
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
S
L
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|525281.3.peg.3174
Escherichia coli 83972
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|655817.3.peg.4346
Escherichia coli ABU 83972
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|199310.1.peg.4499
Escherichia coli CFT073
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|199310.4.peg.4313
Escherichia coli CFT073
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|656393.3.peg.4841
Escherichia coli H299
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|749546.3.peg.1453
Escherichia coli MS 185-1
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|749528.3.peg.2892
Escherichia coli MS 45-1
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|753642.3.peg.4249
Escherichia coli NC101
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|685038.3.peg.3741
Escherichia coli O83:H1 str. NRG 857C
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|656440.3.peg.3986
Escherichia coli TA206
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|670888.3.peg.2545
Escherichia coli 1827-70
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
SACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
S
L
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|340186.3.peg.2344
Escherichia coli E110019
MASSGTT
L
TRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AAAPAFSEES
IR
D
A
A
T
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|340186.5.peg.2421
Escherichia coli E110019
MASSGTT
L
TRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AAAPAFSEES
IR
D
A
A
T
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|481805.3.peg.30
Escherichia coli ATCC 8739
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AAAPAFSEES
IR
D
A
A
T
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|481805.6.peg.30
Escherichia coli ATCC 8739
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AAAPAFSEES
IR
D
A
A
T
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|331112.3.peg.3642
Escherichia coli HS
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AAAPAFSEES
IR
D
A
A
T
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|331112.6.peg.3796
Escherichia coli HS
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AAAPAFSEES
IR
D
A
A
T
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|656419.3.peg.4728
Escherichia coli M718
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AAAPAFSEES
IR
D
A
A
T
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|749537.3.peg.1264
Escherichia coli MS 115-1
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
V
D
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYEQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|405955.13.peg.4130
Escherichia coli APEC O1
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KH
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|405955.9.peg.3457
Escherichia coli APEC O1
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KH
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|714962.3.peg.4164
Escherichia coli IHE3034
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KH
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|585035.6.peg.4025
Escherichia coli S88
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KH
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|869729.3.peg.3980
Escherichia coli UM146
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KH
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|364106.7.peg.4131
Escherichia coli UTI89
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KH
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|364106.8.peg.4133
Escherichia coli UTI89
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KH
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|585397.7.peg.4361
Escherichia coli ED1a
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
K
Y
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|585397.9.peg.4358
Escherichia coli ED1a
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
K
Y
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|362663.8.peg.3903
Escherichia coli 536
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
S
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|362663.9.peg.3918
Escherichia coli 536
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
S
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|550676.3.peg.3887
Escherichia coli B185
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQP
A
V
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
V
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|656417.3.peg.4558
Escherichia coli M605
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
S
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFDI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|340197.3.peg.475
Escherichia coli F11
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
S
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KH
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|340197.5.peg.491
Escherichia coli F11
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
S
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KH
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|749550.3.peg.3399
Escherichia coli MS 200-1
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
S
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KH
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|670897.3.peg.3588
Escherichia coli 2362-75
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
S
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RR
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNET
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|216593.1.peg.4481
Escherichia coli E2348/69
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
S
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RR
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNET
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|574521.7.peg.4062
Escherichia coli O127:H6 str. E2348/69
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
S
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RR
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNET
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|562.376.peg.2506
Escherichia coli WV_060327
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
S
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EEL
S
QVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|431946.3.peg.3666
Escherichia coli SE15
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
S
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
SI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
TQP
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KH
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
L
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNEA
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|749527.3.peg.3417
Escherichia coli MS 21-1
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQA
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPCPI
P
--
KAC
D
P
-
L
SHYG
L
INA
V
AACVDD
S
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNET
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|439855.10.peg.4178
Escherichia coli SMS-3-5
MASSGTTSTRKRFTGA
EF
IV
HF
L
EQ
QG
I
K
I
V
T
G
I
PGGSI
LP
VYDAL
SQS
T
Q
I
R
HIL
A
RHEQ
G
A
GFI
A
Q
G
M
AR
TD
GK
P
AVC
MAC
SGPGATNL
V
T
A
IADA
RL
DSIPL
I
C
ITGQV
P
AS
M
IG
T
DAFQE
V
D
TY
GIS
IPIT
KH
NY
LV
RHI
EELPQVM
SD
AF
RI
A
Q
SGRPGPV
W
I
DIPKDV
QTAVFEI
----
E
AQA
A
M
AEK
---
AAAPAFSEES
IR
D
A
A
A
M
I
NA
A
KR
P
V
LY
L
GGG
VIN
A
P
A
--R
V
R
E
LAEKAQL
P
T
T
M
TL
M
A
LG
ML
P
KA
HP
LS
LGMLGMHG
VRST
N
YI
L
Q
EAD
L
L
IV
LG
A
RFDDR
AIGKTEQ
F
C
P
-
NA
K
IIH
V
DID
R
AE
L
G
K
IKQP
HVAIQ
A
D
VDDV
L
A
QL
I
P
Q
V
EA----
QP
R
A
--
-E
W
H
Q
LV
AD
L
Q
REFPYPI
P
--
KAC
D
P
-
L
THYG
L
INA
V
AACVDD
N
A
II
T
T
DVGQHQMW
T
A
QAYPLNR
PR
QW
L
T
S
G
GLGTMGFGLPAA
I
GA
AL
A
N
P
D
RK
V
L
C
FS
GDGS
LM
MNIQE
MA
TA
S
E
N
QL
D
VKI
I
LM
NN
EA
LG
L
V
H
Q
Q
Q
S
L
FYKQGVFAA
T
YPGKI
NF
MQ
IA
A
G
F
G
LE
T
CD
L
NNET
D
P
Q
A
AL
QEIINR
---
P
GP
A
L
I
HV
R
ID
AE
E
K
V
Y
PMVPPGA
A
N
T
EMVGE
fig|362663.8.peg.3989
Escherichia coli 536 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FSHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKSA
D
C
IV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
THKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|362663.9.peg.4005
Escherichia coli 536 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FSHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKSA
D
C
IV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
THKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|405955.9.peg.3533
Escherichia coli APEC O1 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FSHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKSA
D
C
IV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
THKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|585397.9.peg.4443
Escherichia coli ED1a (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FSHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKSA
D
C
IV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
THKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|340197.3.peg.4488
Escherichia coli F11 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FSHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKSA
D
C
IV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
THKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|340197.5.peg.4693
Escherichia coli F11 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FSHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKSA
D
C
IV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
THKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|714962.3.peg.4253
Escherichia coli IHE3034 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FSHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKSA
D
C
IV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
THKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|749550.3.peg.1183
Escherichia coli MS 200-1 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FSHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKSA
D
C
IV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
THKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|869729.3.peg.4073
Escherichia coli UM146 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FSHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKSA
D
C
IV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
THKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|364106.7.peg.4219
Escherichia coli UTI89 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FSHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKSA
D
C
IV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
THKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|364106.8.peg.4221
Escherichia coli UTI89 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FSHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKSA
D
C
IV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
THKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|656440.3.peg.4078
Escherichia coli TA206 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FSHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHTWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|525281.3.peg.4910
Escherichia coli 83972 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FSHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
IV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
THKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|655817.3.peg.4437
Escherichia coli ABU 83972 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FSHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
IV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
THKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|199310.1.peg.4591
Escherichia coli CFT073 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FSHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
IV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
THKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|199310.4.peg.4401
Escherichia coli CFT073 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FSHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
IV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
THKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|749546.3.peg.1324
Escherichia coli MS 185-1 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FSHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
IV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
THKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|749528.3.peg.3278
Escherichia coli MS 45-1 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FSHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
IV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
THKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|562.376.peg.728
Escherichia coli WV_060327 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FSHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
IV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
THKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|562.371.peg.5547
Escherichia coli 1044A (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LK
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|562.373.peg.5933
Escherichia coli 1125A (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LK
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|562.372.peg.3844
Escherichia coli 1212A (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LK
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|562.374.peg.708
Escherichia coli 536A (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LK
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|83334.1.peg.4673
Escherichia coli O157:H7 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LK
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|155864.1.peg.4707
Escherichia coli O157:H7 EDL933 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LK
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|155864.8.peg.4665
Escherichia coli O157:H7 EDL933 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LK
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|444454.5.peg.3790
Escherichia coli O157:H7 str. EC4024 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LK
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|444449.5.peg.3245
Escherichia coli O157:H7 str. EC4042 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LK
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|444448.5.peg.2000
Escherichia coli O157:H7 str. EC4045 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LK
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|444453.5.peg.2141
Escherichia coli O157:H7 str. EC4076 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LK
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|444452.5.peg.4616
Escherichia coli O157:H7 str. EC4113 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LK
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|444450.8.peg.5082
Escherichia coli O157:H7 str. EC4115 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LK
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|444451.5.peg.3241
Escherichia coli O157:H7 str. EC4196 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LK
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|444447.5.peg.2164
Escherichia coli O157:H7 str. EC4206 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LK
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|478004.5.peg.557
Escherichia coli O157:H7 str. EC4401 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LK
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|478005.5.peg.2069
Escherichia coli O157:H7 str. EC4486 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LK
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|478006.5.peg.4494
Escherichia coli O157:H7 str. EC4501 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LK
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|478007.5.peg.3635
Escherichia coli O157:H7 str. EC508 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LK
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|478008.5.peg.1883
Escherichia coli O157:H7 str. EC869 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LK
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|637388.3.peg.2667
Escherichia coli O157:H7 str. FRIK2000 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LK
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|570506.3.peg.1448
Escherichia coli O157:H7 str. FRIK966 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LK
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|386585.9.peg.4907
Escherichia coli O157:H7 str. Sakai (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LK
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|502346.5.peg.1915
Escherichia coli O157:H7 str. TW14588 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LK
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|701177.3.peg.4576
Escherichia coli O55:H7 str. CB9615 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LK
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|656417.3.peg.4652
Escherichia coli M605 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
A
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
IV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
THKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|431946.3.peg.3755
Escherichia coli SE15 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
A
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
IV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
THKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|585396.4.peg.4756
Escherichia coli O111:H- str. 11128 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHTWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|573235.3.peg.4963
Escherichia coli O26:H11 str. 11368 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHTWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|670897.3.peg.5145
Escherichia coli 2362-75 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHTWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|216593.1.peg.4575
Escherichia coli E2348/69 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHTWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|574521.7.peg.4149
Escherichia coli O127:H6 str. E2348/69 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHTWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|753642.3.peg.3413
Escherichia coli NC101 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
V
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHTWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|83333.1.peg.3698
Escherichia coli K12 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
C
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
Q
ND
W
Q
Q
HC
A
Q
L
R
DEHSWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IH
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|670888.3.peg.2458
Escherichia coli 1827-70 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
NTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|344610.3.peg.3487
Escherichia coli 53638 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
NTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|344610.7.peg.2427
Escherichia coli 53638 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
NTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|481805.3.peg.4560
Escherichia coli ATCC 8739 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
NTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|481805.6.peg.4539
Escherichia coli ATCC 8739 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
NTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|331112.3.peg.3730
Escherichia coli HS (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
NTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|331112.6.peg.3887
Escherichia coli HS (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
NTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|685038.3.peg.3823
Escherichia coli O83:H1 str. NRG 857C (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHTRRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|550672.3.peg.3841
Escherichia coli B088 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
HC
A
Q
L
R
DEHSWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|585034.4.peg.3858
Escherichia coli IAI1 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
HC
A
Q
L
R
DEHSWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|585034.5.peg.3855
Escherichia coli IAI1 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
HC
A
Q
L
R
DEHSWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|656444.3.peg.5104
Escherichia coli TA280 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
NV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVN--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
V
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQV
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|656393.3.peg.4937
Escherichia coli H299 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
M
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
Q
D
D
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKSA
D
C
IV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
THKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EF
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|749537.3.peg.4880
Escherichia coli MS 115-1 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AA
AF
EV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|1040638.4.peg.1387
Escherichia coli O104:H4 str. LB226692 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AA
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHTWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|6666666.5357.peg.1120
Escherichia coli TY-2482 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AA
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHTWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|585055.6.peg.4268
Escherichia coli 55989 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AA
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHTWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|585055.8.peg.4271
Escherichia coli 55989 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AA
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHTWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|656414.3.peg.4298
Escherichia coli H736 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
C
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
HC
A
Q
L
R
DEHSWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IH
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|749538.3.peg.931
Escherichia coli MS 116-1 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
C
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
HC
A
Q
L
R
DEHSWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IH
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|749540.3.peg.2651
Escherichia coli MS 146-1 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
C
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
HC
A
Q
L
R
DEHSWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IH
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|749544.3.peg.1078
Escherichia coli MS 175-1 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
C
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
HC
A
Q
L
R
DEHSWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IH
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|749548.3.peg.4575
Escherichia coli MS 196-1 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
C
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
HC
A
Q
L
R
DEHSWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IH
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|679207.4.peg.3711
Escherichia coli MS 107-1 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AA
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHTWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EF
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|562.375.peg.225
Escherichia coli EC4100B (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AA
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHTWCY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|340186.3.peg.4258
Escherichia coli E110019 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AA
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
HC
A
Q
L
R
DEHSWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|340186.5.peg.4478
Escherichia coli E110019 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AA
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
HC
A
Q
L
R
DEHSWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|585057.4.peg.3124
Escherichia coli IAI39 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
M
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
L
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHTWRY
D
--
HPG
D
A
-
I
YAPL
L
LKK
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|585057.6.peg.3130
Escherichia coli IAI39 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
M
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
L
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHTWRY
D
--
HPG
D
A
-
I
YAPL
L
LKK
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|550677.3.peg.4346
Escherichia coli B354 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVN--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATAKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
L
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QG
N
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHTWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|439855.10.peg.4270
Escherichia coli SMS-3-5 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
M
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
H
A
A
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
IV
T
T
DVGQHQMW
S
A
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|749527.3.peg.4539
Escherichia coli MS 21-1 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
M
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
H
A
A
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
IV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|216592.1.peg.1144
Escherichia coli 042 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
G
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVN--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
V
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
L
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHTWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|216592.3.peg.4297
Escherichia coli 042 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
G
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVN--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
V
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
L
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHTWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|656379.3.peg.5002
Escherichia coli FVEC1302 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
G
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVN--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
V
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
L
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHTWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|656380.3.peg.4901
Escherichia coli FVEC1412 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
G
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVN--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
V
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
L
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHTWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|749549.3.peg.4402
Escherichia coli MS 198-1 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
G
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVN--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
V
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
L
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHTWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|585056.7.peg.4461
Escherichia coli UMN026 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
G
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVN--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
V
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
L
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHTWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|656437.3.peg.4248
Escherichia coli TA143 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVN--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
V
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
L
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHTWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|550676.3.peg.3975
Escherichia coli B185 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLSTTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|405955.13.peg.4216
Escherichia coli APEC O1 (1-538/542)
M
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FSHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKSA
D
C
IV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
THKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|585397.7.peg.4446
Escherichia coli ED1a (1-538/542)
M
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FSHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKSA
D
C
IV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
THKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|585035.6.peg.4113
Escherichia coli S88 (1-538/542)
M
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
IL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FSHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKSA
D
C
IV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
THKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|340184.3.peg.1106
Escherichia coli B7A (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|340184.6.peg.1166
Escherichia coli B7A (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|340185.3.peg.4500
Escherichia coli E22 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|340185.4.peg.4746
Escherichia coli E22 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|595495.4.peg.3112
Escherichia coli KO11 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|656419.3.peg.4857
Escherichia coli M718 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|679205.4.peg.2175
Escherichia coli MS 124-1 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|679204.3.peg.3414
Escherichia coli MS 145-7 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|749533.3.peg.2014
Escherichia coli MS 84-1 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|585395.4.peg.4602
Escherichia coli O103:H2 str. 12009 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|566546.3.peg.3653
Escherichia coli W (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|566546.4.peg.4016
Escherichia coli W (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|749531.3.peg.2227
Escherichia coli MS 69-1 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VSA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
L-----
QPL
N
-
I
DD
W
Q
Q
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
IV
T
T
DVGQHQMWAA
QHIVHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|544404.4.peg.4892
Escherichia coli O157:H7 str. TW14359 (1-538/542)
M
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LK
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|358709.5.peg.3385
Escherichia coli 101-1 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
C
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|511693.5.peg.3844
Escherichia coli BL21 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
C
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|469008.4.peg.4443
Escherichia coli BL21(DE3) (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
C
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|749547.3.peg.2294
Escherichia coli MS 187-1 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
C
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|344601.3.peg.4114
Escherichia coli B171 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDP
T
E
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|344601.5.peg.4332
Escherichia coli B171 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDP
T
E
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|331111.3.peg.1914
Escherichia coli E24377A (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
V
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|656408.3.peg.4230
Escherichia coli H591 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
V
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|679206.4.peg.4972
Escherichia coli MS 119-7 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
V
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|749545.3.peg.1400
Escherichia coli MS 182-1 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
V
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|749532.3.peg.496
Escherichia coli MS 78-1 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
V
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|656443.3.peg.4709
Escherichia coli TA271 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
V
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|409438.11.peg.4223
Escherichia coli SE11 (1-538/542)
M
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AA
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
YC
A
Q
L
R
DEHTWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|413997.3.peg.3826
Escherichia coli B str. REL606 (1-538/542)
M
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
C
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|331111.12.peg.4513
Escherichia coli E24377A (1-538/542)
M
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AMA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
S
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
V
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLATTKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
L
HC
A
Q
L
R
DEHAWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|316401.4.peg.4595
Escherichia coli ETEC H10407 (3-544/548)
GA
QW
V
V
HA
L
RA
QGV
N
T
V
F
G
Y
PGG
A
I
MP
VYDAL
YDG
G
-
V
E
H
L
L
C
RHEQ
G
A
AIA
A
I
G
Y
AR
AT
GK
T
G
VC
IAT
SGPGATNLITG
L
ADA
LL
DSIP
V
V
A
ITGQV
S
A
P
F
IG
T
DAFQE
V
D
VL
G
L
S
LACT
KH
SF
LV
QSL
EELP
RI
M
AE
AF
DV
A
C
SGRPGPV
L
VDIPKD
I
QLASGDL
----
E
PWF
T
T
VEN
---
EVT--FPHAE
V
E
Q
A
R
Q
M
L
AK
A
QK
P
M
LY
V
GGG
VGM
A
Q
A
VPA
L
R
E
FLAATKM
P
A
T
C
TL
K
GLG
AV
E
AD
Y
P
YY
LGMLGMHG
TKAA
N
FA
V
Q
E
C
D
L
L
IA
V
G
A
RFDDR
VTGKLNT
F
A
P
-
H
A
S
V
IH
M
DIDPAE
M
N
K
LRQA
HVA
L
QGD
----
L
N
A
LLP
A
L
Q-----
QPL
N
-
I
ND
W
Q
Q
HC
A
Q
L
R
DEHSWRY
D
--
HPG
D
A
-
I
YAPL
L
LKQ
L
SDRKPA
D
C
VV
T
T
DVGQHQMWAA
QHIAHTR
P
E
NF
I
T
S
S
GLGTMGFGLPAA
V
GA
QV
A
R
P
N
DT
VVC
IS
GDGS
FM
MN
V
QE
LG
T
V
K
R
K
QLP
L
KIV
LL
D
N
QR
LG
M
V
R
Q
W
Q
Q
L
FFQERYSET
T
LTDNP
D
F
LM
L
A
S
A
F
G
IP
G
QH
I
TRKD
Q
V
E
A
AL
DTMLNS
---
D
GP
Y
L
L
HV
S
ID
EL
E
N
V
W
P
L
VPPGA
S
N
S
EM
L
fig|340197.3.peg.4332
Escherichia coli F11 (32-594/602)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HLQ
L
K
E
AVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTNG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|216593.1.peg.3495
Escherichia coli E2348/69 (34-596/604)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESVH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTNG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|574521.7.peg.85
Escherichia coli O127:H6 str. E2348/69 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESVH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTNG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|199310.1.peg.92
Escherichia coli CFT073 (34-596/604)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTNG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|749528.3.peg.2231
Escherichia coli MS 45-1 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTNG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|562.376.peg.1230
Escherichia coli WV_060327 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTNG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|550677.3.peg.467
Escherichia coli B354 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESVH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
SYS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|749527.3.peg.3177
Escherichia coli MS 21-1 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESVH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
VRQCLKY
D
--
SHS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|405955.9.peg.66
Escherichia coli APEC O1 (34-596/604)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTHG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|869729.3.peg.4986
Escherichia coli UM146 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTHG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|364106.7.peg.217
Escherichia coli UTI89 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTHG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|364106.8.peg.216
Escherichia coli UTI89 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTHG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|656379.3.peg.319
Escherichia coli FVEC1302 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PY
I
WP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESVH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
SHS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
AHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|344610.3.peg.4312
Escherichia coli 53638 (32-594/602)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
C
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|481805.3.peg.3844
Escherichia coli ATCC 8739 (32-594/602)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
C
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|83333.1.peg.78
Escherichia coli K12 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
C
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|749538.3.peg.3058
Escherichia coli MS 116-1 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
C
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|316407.3.peg.77
Escherichia coli W3110 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
C
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|216592.1.peg.4331
Escherichia coli 042 (32-594/602)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|340184.3.peg.2847
Escherichia coli B7A (32-594/602)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|331111.3.peg.2649
Escherichia coli E24377A (32-594/602)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|679204.3.peg.3195
Escherichia coli MS 145-7 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|749545.3.peg.1304
Escherichia coli MS 182-1 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|6666666.5357.peg.1772
Escherichia coli TY-2482 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
V
C
N
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|340185.3.peg.4255
Escherichia coli E22 (32-594/602)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
V
C
N
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|331112.3.peg.78
Escherichia coli HS (32-594/602)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
V
C
N
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|585396.4.peg.80
Escherichia coli O111:H- str. 11128 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
V
C
N
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|562.371.peg.4017
Escherichia coli 1044A (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
G
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
G
A
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|562.373.peg.2188
Escherichia coli 1125A (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
G
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
G
A
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|562.372.peg.3039
Escherichia coli 1212A (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
G
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
G
A
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|562.374.peg.2230
Escherichia coli 536A (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
G
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
G
A
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|83334.1.peg.169
Escherichia coli O157:H7 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
G
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
G
A
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|155864.1.peg.81
Escherichia coli O157:H7 EDL933 (32-594/602)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
G
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
G
A
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|155864.8.peg.82
Escherichia coli O157:H7 EDL933 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
G
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
G
A
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|444454.5.peg.4545
Escherichia coli O157:H7 str. EC4024 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
G
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
G
A
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|444449.5.peg.3994
Escherichia coli O157:H7 str. EC4042 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
G
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
G
A
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|444448.5.peg.2753
Escherichia coli O157:H7 str. EC4045 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
G
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
G
A
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|444453.5.peg.3356
Escherichia coli O157:H7 str. EC4076 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
G
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
G
A
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|444452.5.peg.4320
Escherichia coli O157:H7 str. EC4113 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
G
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
G
A
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|444450.8.peg.223
Escherichia coli O157:H7 str. EC4115 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
G
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
G
A
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|444451.5.peg.4397
Escherichia coli O157:H7 str. EC4196 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
G
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
G
A
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|444447.5.peg.2921
Escherichia coli O157:H7 str. EC4206 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
G
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
G
A
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|478004.5.peg.2453
Escherichia coli O157:H7 str. EC4401 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
G
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
G
A
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|478005.5.peg.4949
Escherichia coli O157:H7 str. EC4486 (32-594/602)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
G
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
G
A
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|478006.5.peg.4389
Escherichia coli O157:H7 str. EC4501 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
G
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
G
A
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|478007.5.peg.4111
Escherichia coli O157:H7 str. EC508 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
G
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
G
A
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|478008.5.peg.4668
Escherichia coli O157:H7 str. EC869 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
G
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
G
A
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|637388.3.peg.3920
Escherichia coli O157:H7 str. FRIK2000 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
G
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
G
A
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|570506.3.peg.1084
Escherichia coli O157:H7 str. FRIK966 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
G
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
G
A
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|386585.9.peg.181
Escherichia coli O157:H7 str. Sakai (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
G
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
G
A
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|544404.4.peg.85
Escherichia coli O157:H7 str. TW14359 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
G
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
G
A
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|502346.5.peg.1182
Escherichia coli O157:H7 str. TW14588 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
G
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
G
A
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|701177.3.peg.82
Escherichia coli O55:H7 str. CB9615 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
G
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
G
A
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|340186.3.peg.4047
Escherichia coli E110019 (32-594/602)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|340186.5.peg.4254
Escherichia coli E110019 (4-566/574)
LS
GA
EM
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|362663.8.peg.85
Escherichia coli 536 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HLQ
L
K
E
AVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTNG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|362663.9.peg.85
Escherichia coli 536 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HLQ
L
K
E
AVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTNG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|340197.5.peg.4525
Escherichia coli F11 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HLQ
L
K
E
AVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTNG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|749550.3.peg.2596
Escherichia coli MS 200-1 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HLQ
L
K
E
AVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTNG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|656444.3.peg.414
Escherichia coli TA280 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
VF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESVH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
SHS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|670897.3.peg.1897
Escherichia coli 2362-75 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESVH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTNG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|656393.3.peg.693
Escherichia coli H299 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESVH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTNG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|749531.3.peg.4536
Escherichia coli MS 69-1 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
AA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESVH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|525281.3.peg.1190
Escherichia coli 83972 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTNG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|655817.3.peg.89
Escherichia coli ABU 83972 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTNG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|199310.4.peg.89
Escherichia coli CFT073 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTNG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|585397.7.peg.85
Escherichia coli ED1a (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTNG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|585397.9.peg.85
Escherichia coli ED1a (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTNG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|749546.3.peg.2386
Escherichia coli MS 185-1 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTNG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|431946.3.peg.87
Escherichia coli SE15 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTNG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|656440.3.peg.5138
Escherichia coli TA206 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTNG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|358709.5.peg.4139
Escherichia coli 101-1 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
MVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|413997.3.peg.84
Escherichia coli B str. REL606 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
MVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|511693.5.peg.85
Escherichia coli BL21 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
MVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|469008.4.peg.3660
Escherichia coli BL21(DE3) (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
MVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|595496.3.peg.82
Escherichia coli BW2952 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
MVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|749547.3.peg.3862
Escherichia coli MS 187-1 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
MVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|585057.4.peg.90
Escherichia coli IAI39 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESVH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
SHS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|585057.6.peg.89
Escherichia coli IAI39 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESVH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
SHS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|656437.3.peg.140
Escherichia coli TA143 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PY
I
WP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESVH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
SYS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|439855.10.peg.258
Escherichia coli SMS-3-5 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
F
E
L
L
SQESVH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
SHS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|405955.13.peg.86
Escherichia coli APEC O1 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTHG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|714962.3.peg.84
Escherichia coli IHE3034 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTHG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|753642.3.peg.3555
Escherichia coli NC101 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTHG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|685038.3.peg.79
Escherichia coli O83:H1 str. NRG 857C (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTHG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|585035.6.peg.88
Escherichia coli S88 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HLQ
L
K
E
AVEVLNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTHG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|656380.3.peg.257
Escherichia coli FVEC1412 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PY
I
WP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESVH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
SHS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
AHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|749549.3.peg.4572
Escherichia coli MS 198-1 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PY
I
WP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESVH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
SHS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
AHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|585056.7.peg.268
Escherichia coli UMN026 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PY
I
WP
ESV
S
M
RSY
---
NPTTSGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESVH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
SHS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
AHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|656414.3.peg.198
Escherichia coli H736 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
C
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WQLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|656417.3.peg.141
Escherichia coli M605 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESVH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
SHS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPQ
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|670888.3.peg.657
Escherichia coli 1827-70 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
C
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|344610.7.peg.1660
Escherichia coli 53638 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
C
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|481805.6.peg.3823
Escherichia coli ATCC 8739 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
C
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|536056.3.peg.3723
Escherichia coli DH1 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
C
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|316401.4.peg.86
Escherichia coli ETEC H10407 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
C
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|749537.3.peg.3174
Escherichia coli MS 115-1 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
C
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|749540.3.peg.2853
Escherichia coli MS 146-1 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
C
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|749544.3.peg.1715
Escherichia coli MS 175-1 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
C
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|749548.3.peg.4247
Escherichia coli MS 196-1 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
C
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|511145.12.peg.80
Escherichia coli str. K-12 substr. MG1655 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
C
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|511145.6.peg.81
Escherichia coli str. K-12 substr. MG1655 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
C
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|216592.3.peg.88
Escherichia coli 042 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|550676.3.peg.4746
Escherichia coli B185 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|340184.6.peg.2978
Escherichia coli B7A (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|331111.12.peg.410
Escherichia coli E24377A (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|656408.3.peg.5031
Escherichia coli H591 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|595495.4.peg.1647
Escherichia coli KO11 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|679207.4.peg.1118
Escherichia coli MS 107-1 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
CD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|679206.4.peg.1693
Escherichia coli MS 119-7 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|749532.3.peg.4187
Escherichia coli MS 78-1 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|656443.3.peg.209
Escherichia coli TA271 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|566546.3.peg.1653
Escherichia coli W (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|566546.4.peg.76
Escherichia coli W (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIT
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|1040638.4.peg.5638
Escherichia coli O104:H4 str. LB226692 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
V
C
N
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|585055.6.peg.80
Escherichia coli 55989 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
V
C
N
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|585055.8.peg.80
Escherichia coli 55989 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
V
C
N
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|340185.4.peg.4488
Escherichia coli E22 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
V
C
N
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|562.375.peg.2575
Escherichia coli EC4100B (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
V
C
N
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|331112.6.peg.83
Escherichia coli HS (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
V
C
N
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|679205.4.peg.2337
Escherichia coli MS 124-1 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
V
C
N
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|749533.3.peg.3361
Escherichia coli MS 84-1 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
V
C
N
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|585395.4.peg.79
Escherichia coli O103:H2 str. 12009 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
V
C
N
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|573235.3.peg.82
Escherichia coli O26:H11 str. 11368 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
V
C
N
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|550672.3.peg.4349
Escherichia coli B088 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|585034.4.peg.79
Escherichia coli IAI1 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|585034.5.peg.79
Escherichia coli IAI1 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|409438.11.peg.196
Escherichia coli SE11 (2-558/566)
V
V
RS
L
ID
QGVK
Q
V
F
G
Y
PGG
A
V
LD
I
YDAL
HTV
G
G
I
D
H
V
L
V
RHEQ
A
A
VHM
A
D
G
L
AR
AT
G
E
V
G
V
V
LVT
SGPGATN
A
ITGIA
T
A
YM
DSIPLV
V
L
S
GQV
A
T
S
L
IG
Y
DAFQE
C
D
MV
GIS
RPVV
KH
SF
LV
KQT
E
D
I
PQV
L
KK
AF
WL
A
A
SGRPGPV
V
VD
L
PKD
I
LNPANKL
PYVWP
ESV
S
M
RSY
---
NPTTTGHKGQ
I
K
R
A
L
Q
T
L
VA
A
KK
P
V
V
Y
V
GGG
AIM
A
G
C
HQQ
L
K
E
TVEALNL
P
V
V
S
S
L
M
GLG
AF
P
AT
H
R
QA
LGMLGMHG
TYEA
N
MT
M
H
N
AD
V
I
FA
V
G
V
RFDDR
TTNNLAK
Y
C
P
-
NA
T
VL
HIDIDP
TS
I
S
K
TVTA
D
I
P
I
V
GD
ARQV
L
E
Q
M
L
E
L
L
SQESAH
QPL
D
EI
RD
W
W
Q
QI
EQ
W
R
ARQCLKY
D
--
THS
E
K
-
I
KPQA
V
IET
L
WRLTKG
DA
YV
T
S
DVGQHQM
F
AA
LYYPFDK
PR
RW
I
N
S
G
GLGTMGFGLPAALG
V
KM
A
L
PE
ET
VVC
VT
GDGS
IQ
MNIQE
LS
TA
L
Q
Y
E
LPV
LV
V
NL
NN
RY
LG
M
V
K
Q
W
Q
D
M
IYSGRHSQS
Y
MQSLP
D
F
VR
L
A
E
A
Y
G
HV
G
IQ
I
SHPH
E
L
E
S
K
L
SEALEQ
VRN
N
RL
V
F
V
D
V
T
V
D
GS
E
H
V
Y
PM
QIR
G
G
G
M
D
EM
fig|344601.3.peg.2463
Escherichia coli B171 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
YD
V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
LV
GD
IKST
L
R
A
LLP
L
V
EEKADR
KF
L
D
--
--
-
-
K
AL
E
D
Y
R
DARKGLD
D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
SHFAAD
DA
IF
T
C
DVG
TPTV
WAA
RYLKMNG
K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
W
G
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G
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V
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E
V
D
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AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|344601.5.peg.2566
Escherichia coli B171 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
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RECS
HY
CE
LV
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E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
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T
T
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QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
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A
G
A
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L
V
E
FAGKIKA
P
I
V
H
A
L
R
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KE
HV
E
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N
P
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V
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T
G
LI
G
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F
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M
M
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T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
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S
I
G
A
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M
A
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L
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R
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A
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K
R
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L
G
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F
NH
G
S
M
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P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
W
G
IT
G
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V
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E
V
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|656437.3.peg.1006
Escherichia coli TA143 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
S
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
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N
P
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V
GM
T
G
LI
G
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F
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M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
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M
A
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R
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L
V
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L
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--
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R
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D
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A
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L
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IF
T
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K
R
RL
L
G
S
F
NH
G
S
M
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P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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I
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
V
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|550677.3.peg.2144
Escherichia coli B354 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
S
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
YD
V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
LV
GD
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L
R
A
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L
V
EEKTDR
KF
L
D
--
--
-
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K
AL
E
D
Y
R
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D
LA
KPS
E
K
A
I
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L
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I
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DA
IF
T
C
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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I
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
V
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|656417.3.peg.1109
Escherichia coli M605 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
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A
G
A
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L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
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N
P
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V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
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D
M
A
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L
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L
V
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L
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--
--
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AR
E
D
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R
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D
LA
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K
A
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L
AQQ
I
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DA
IF
T
C
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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VF
NN
SV
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F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
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AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|362663.8.peg.894
Escherichia coli 536 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
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----
P
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T
T
HWY
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L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
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A
G
A
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L
V
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FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
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V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
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D
M
A
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L
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L
V
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L
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--
--
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D
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R
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D
LA
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K
A
I
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L
AQQ
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DA
IF
T
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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I
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|362663.9.peg.894
Escherichia coli 536 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
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T
T
HWY
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QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
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A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
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V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
LV
GD
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L
R
A
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L
V
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KF
L
D
--
--
-
-
K
AL
E
D
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R
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D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
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DA
IF
T
C
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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I
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
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AL
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|340197.3.peg.2162
Escherichia coli F11 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
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LI
N
G
LF
D
C
HR
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P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
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ALKPA--
----
P
EGA
T
T
HWY
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QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
YD
V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
LV
GD
IKST
L
R
A
LLP
L
V
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KF
L
D
--
--
-
-
K
AL
E
D
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R
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D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
SHFAAD
DA
IF
T
C
DVG
TPTV
WAA
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
LPVKI
I
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
ELHDT
NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|340197.5.peg.2276
Escherichia coli F11 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
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D
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fig|749550.3.peg.3695
Escherichia coli MS 200-1 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
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D
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fig|585397.7.peg.846
Escherichia coli ED1a (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
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D
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fig|585397.9.peg.846
Escherichia coli ED1a (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
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L
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S
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T
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I
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---
D
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fig|656440.3.peg.780
Escherichia coli TA206 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
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---
D
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P
fig|216592.1.peg.5117
Escherichia coli 042 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
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L
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S
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---
D
GP
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D
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L
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P
fig|216592.3.peg.994
Escherichia coli 042 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
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G
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H
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T
L
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T
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P
T
D
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P
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T
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A
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M
L
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---
D
GP
V
LV
D
V
V
VA
KE
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L
A
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P
fig|656379.3.peg.1720
Escherichia coli FVEC1302 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
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V
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M
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T
L
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LG
T
Q
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R
A------
F
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P
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M
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T
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K
R
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L
G
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NH
G
S
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P
Q
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QA
T
E
PE
RQ
VV
A
MC
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G
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M
L
M
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SV
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F
V
A
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-
M
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M
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T
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NF
AR
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E
A
C
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V
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E
V
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AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|656380.3.peg.1547
Escherichia coli FVEC1412 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
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QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
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A
G
A
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L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
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HV
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P
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T
G
LI
G
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M
M
N
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L
VL
LG
T
Q
F
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R
A------
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Y
P
T
D
A
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PA
S
I
G
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M
A
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R
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A
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K
R
RL
L
G
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F
NH
G
S
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P
Q
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QA
T
E
PE
RQ
VV
A
MC
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G
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M
L
M
GD
FL
SV
V
Q
M
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F
V
A
-
-
M
E
M
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T
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AR
IA
E
A
C
G
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IR
V
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E
V
D
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QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|749549.3.peg.4954
Escherichia coli MS 198-1 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
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A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
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N
P
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V
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T
G
LI
G
FSSG
F
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M
M
N
AD
T
L
VL
LG
T
Q
F
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R
A------
F
Y
P
T
D
A
K
II
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PA
S
I
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D
M
A
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--
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R
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A
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L
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IF
T
C
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
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IR
V
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E
V
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|585056.7.peg.1259
Escherichia coli UMN026 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
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P
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V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
LV
GD
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L
R
A
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L
V
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L
D
--
--
-
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K
AL
E
D
Y
R
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D
LA
KPS
E
K
A
I
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L
AQQ
I
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DA
IF
T
C
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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NN
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LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
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IR
V
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E
V
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|749531.3.peg.1672
Escherichia coli MS 69-1 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
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LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
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ALKPA--
----
P
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T
S
HWY
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QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
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G
A
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L
V
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P
I
V
H
A
L
R
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KE
HV
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P
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T
G
LI
G
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F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
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N
PA
S
I
G
A
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D
M
A
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L
R
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L
V
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L
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--
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D
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R
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D
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A
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L
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IF
T
C
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
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E
V
D
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AL
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|585057.4.peg.902
Escherichia coli IAI39 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
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QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
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A
G
A
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L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
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N
P
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V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
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D
M
A
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L
V
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L
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--
--
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AL
E
D
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R
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D
LA
KPS
E
K
A
I
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L
AQQ
I
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DA
IF
T
C
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
M
Q
M
K
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I
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
V
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|585057.6.peg.899
Escherichia coli IAI39 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
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G
A
HKE
L
V
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FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
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V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
LV
GD
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L
R
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L
V
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L
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--
--
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AL
E
D
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R
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D
LA
KPS
E
K
A
I
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L
AQQ
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DA
IF
T
C
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WAA
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
M
Q
M
K
LPVKI
I
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
ELHDT
NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
V
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|749527.3.peg.105
Escherichia coli MS 21-1 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
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LI
N
G
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D
C
HR
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P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
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HY
CE
LV
SSP
E
Q
I
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L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
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T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
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L
M
C
G
S
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G
A
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L
V
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P
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V
H
A
L
R
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HV
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N
P
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V
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T
G
LI
G
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F
HT
M
M
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AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
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N
PA
S
I
G
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M
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L
G
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G
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M
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P
Q
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QA
T
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RQ
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A
MC
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G
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M
L
M
GD
FL
SV
M
Q
M
K
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F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
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IA
E
A
C
G
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V
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---
D
GP
V
LV
D
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V
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P
fig|439855.10.peg.1057
Escherichia coli SMS-3-5 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
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G
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L
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L
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I
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T
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V
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---
D
GP
V
LV
D
V
V
VA
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L
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P
fig|685038.3.peg.797
Escherichia coli O83:H1 str. NRG 857C (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
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L
NG
L
S
D
S
L
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G
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I
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S
T
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E
V
A
AFA
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G
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G
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L
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N
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L
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S
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T
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----
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L
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L
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T
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
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P
fig|562.371.peg.2167
Escherichia coli 1044A (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
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M
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T
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E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
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C
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N
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LF
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C
HR
NHV
P
V
L
A
I
A
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P
S
S
E
IG
S
GY
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T
H
PQ
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HY
CE
LV
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E
Q
I
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L
AI
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M
RK
A
V
LN
R
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----
P
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T
T
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R
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L
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Q
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L
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L
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H
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L
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T
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P
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G
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T
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L
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|562.373.peg.1150
Escherichia coli 1125A (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
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S
L
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G
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T
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E
V
A
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A
G
A
E
A
Q
LS
G
E
L
AVC
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D
C
HR
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P
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L
A
I
A
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S
S
E
IG
S
GY
FQE
T
H
PQ
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HY
CE
LV
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E
Q
I
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L
AI
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M
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A
V
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----
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T
T
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R
K
L
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V
H
A
L
R
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HV
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M
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T
L
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LG
T
Q
F
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R
A------
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P
T
D
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S
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M
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K
R
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G
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G
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P
Q
ALGA
QA
T
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VV
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M
L
M
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SV
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AR
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I
D
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|562.372.peg.1015
Escherichia coli 1212A (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
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L
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L
S
D
S
L
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G
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T
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V
A
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A
G
A
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A
Q
LS
G
E
L
AVC
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C
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C
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P
V
L
A
I
A
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P
S
S
E
IG
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GY
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T
H
PQ
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HY
CE
LV
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E
Q
I
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L
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A
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A
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----
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T
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R
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L
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L
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L
M
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H
A
L
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HV
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L
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T
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A------
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P
T
D
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M
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K
R
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L
G
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F
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G
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P
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QA
T
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VV
A
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M
L
M
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SV
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NF
AR
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I
D
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|562.374.peg.2549
Escherichia coli 536A (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
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L
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L
S
D
S
L
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G
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V
A
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A
G
A
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A
Q
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G
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L
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P
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L
A
I
A
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S
S
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IG
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T
H
PQ
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HY
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E
Q
I
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L
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A
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A
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----
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L
R
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L
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M
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V
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P
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V
H
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L
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HV
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M
M
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T
L
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LG
T
Q
F
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R
A------
F
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P
T
D
A
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II
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PA
S
I
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M
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A
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K
R
RL
L
G
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F
NH
G
S
M
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P
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QA
T
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PE
RQ
VV
A
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G
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M
L
M
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V
Q
M
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F
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KAGGYLTDG
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AR
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E
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I
D
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|656419.3.peg.1165
Escherichia coli M718 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
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L
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D
S
L
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G
T
I
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T
RHE
E
V
A
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A
G
A
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A
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LS
G
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L
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C
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D
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P
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L
A
I
A
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P
S
S
E
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S
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T
H
PQ
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HY
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E
Q
I
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L
AI
A
M
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A
V
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V
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G
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T
T
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L
R
K
L
A
Q
L
L
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SN
I
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L
M
C
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G
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L
V
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P
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V
H
A
L
R
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HV
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P
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T
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G
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F
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M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
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D
M
A
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L
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L
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--
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R
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D
LA
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K
A
I
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L
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I
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IF
T
C
DVG
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WAA
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
E
AL
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|83334.1.peg.1025
Escherichia coli O157:H7 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
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C
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LI
N
G
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D
C
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P
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L
A
I
A
AHI
P
S
S
E
IG
S
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FQE
T
H
PQ
ELF
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HY
CE
LV
SSP
E
Q
I
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L
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A
M
RK
A
V
LN
R
-
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VS
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V
VL
P
G
DV
ALKPA--
----
P
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T
T
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L
R
K
L
A
Q
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T
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K
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L
G
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NH
G
S
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P
Q
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QA
T
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PE
RQ
VV
A
MC
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G
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M
L
M
GD
FL
SV
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F
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-
M
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AR
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A
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I
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QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|155864.1.peg.951
Escherichia coli O157:H7 EDL933 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
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RECS
HY
CE
LV
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E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
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V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
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A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
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N
P
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T
G
LI
G
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F
HT
M
M
N
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T
L
VL
LG
T
Q
F
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R
A------
F
Y
P
T
D
A
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S
I
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M
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--
--
-
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AL
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D
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R
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LA
KPS
E
K
A
I
HPQY
L
AQQ
I
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IF
T
C
DVG
TPTV
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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VF
NN
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LG
F
V
A
-
-
M
E
M
KAGGYLTDG
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AR
IA
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A
C
G
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V
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I
D
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AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|444454.5.peg.5451
Escherichia coli O157:H7 str. EC4024 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
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N
P
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T
G
LI
G
FSSG
F
HT
M
M
N
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T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
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S
I
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M
A
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AL
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R
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LA
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K
A
I
HPQY
L
AQQ
I
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IF
T
C
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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NN
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LG
F
V
A
-
-
M
E
M
KAGGYLTDG
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NF
AR
IA
E
A
C
G
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V
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E
I
D
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AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|444449.5.peg.4384
Escherichia coli O157:H7 str. EC4042 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
YD
V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
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N
PA
S
I
G
A
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D
M
A
LV
GD
IKST
L
R
A
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L
V
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KF
L
D
--
--
-
-
K
AL
E
D
Y
R
DARKGLD
D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
SHFAAD
DA
IF
T
C
DVG
TPTV
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
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AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|444448.5.peg.3661
Escherichia coli O157:H7 str. EC4045 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
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A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
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N
P
YD
V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
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D
M
A
LV
GD
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L
R
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L
V
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L
D
--
--
-
-
K
AL
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D
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R
DARKGLD
D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
SHFAAD
DA
IF
T
C
DVG
TPTV
WAA
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
LPVKI
I
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|444453.5.peg.1001
Escherichia coli O157:H7 str. EC4076 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
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L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
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A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
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N
P
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V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
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PA
S
I
G
A
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D
M
A
LV
GD
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L
R
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L
V
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L
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--
--
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AL
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D
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R
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D
LA
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E
K
A
I
HPQY
L
AQQ
I
SHFAAD
DA
IF
T
C
DVG
TPTV
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
LPVKI
I
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|444452.5.peg.3046
Escherichia coli O157:H7 str. EC4113 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
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QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
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N
P
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V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
LV
GD
IKST
L
R
A
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L
V
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KF
L
D
--
--
-
-
K
AL
E
D
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R
DARKGLD
D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
SHFAAD
DA
IF
T
C
DVG
TPTV
WAA
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
LPVKI
I
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
ELHDT
NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|444450.8.peg.1118
Escherichia coli O157:H7 str. EC4115 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
YD
V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
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L
R
A
LLP
L
V
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L
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--
--
-
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K
AL
E
D
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R
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D
LA
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E
K
A
I
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L
AQQ
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IF
T
C
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
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Q
M
K
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LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
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V
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I
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AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|444451.5.peg.3931
Escherichia coli O157:H7 str. EC4196 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
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A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
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N
P
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T
G
LI
G
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F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
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II
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S
I
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D
M
A
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GD
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L
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--
--
-
-
K
AL
E
D
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R
DARKGLD
D
LA
KPS
E
K
A
I
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L
AQQ
I
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IF
T
C
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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LG
F
V
A
-
-
M
E
M
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T
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NF
AR
IA
E
A
C
G
IT
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V
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E
I
D
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AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|444447.5.peg.3857
Escherichia coli O157:H7 str. EC4206 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
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N
P
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V
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T
G
LI
G
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F
HT
M
M
N
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T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
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PA
S
I
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D
M
A
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GD
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L
V
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L
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--
--
-
-
K
AL
E
D
Y
R
DARKGLD
D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
SHFAAD
DA
IF
T
C
DVG
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
LPVKI
I
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|478004.5.peg.3378
Escherichia coli O157:H7 str. EC4401 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
YD
V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
LV
GD
IKST
L
R
A
LLP
L
V
EEKADR
KF
L
D
--
--
-
-
K
AL
E
D
Y
R
DARKGLD
D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
SHFAAD
DA
IF
T
C
DVG
TPTV
WAA
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
LPVKI
I
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|478005.5.peg.1500
Escherichia coli O157:H7 str. EC4486 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
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V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
LV
GD
IKST
L
R
A
LLP
L
V
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L
D
--
--
-
-
K
AL
E
D
Y
R
DARKGLD
D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
SHFAAD
DA
IF
T
C
DVG
TPTV
WAA
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
LPVKI
I
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|478006.5.peg.3673
Escherichia coli O157:H7 str. EC4501 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
YD
V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
LV
GD
IKST
L
R
A
LLP
L
V
EEKADR
KF
L
D
--
--
-
-
K
AL
E
D
Y
R
DARKGLD
D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
SHFAAD
DA
IF
T
C
DVG
TPTV
WAA
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
LPVKI
I
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
ELHDT
NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|478007.5.peg.2553
Escherichia coli O157:H7 str. EC508 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
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V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
LV
GD
IKST
L
R
A
LLP
L
V
EEKADR
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L
D
--
--
-
-
K
AL
E
D
Y
R
DARKGLD
D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
SHFAAD
DA
IF
T
C
DVG
TPTV
WAA
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
LPVKI
I
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
ELHDT
NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|478008.5.peg.2352
Escherichia coli O157:H7 str. EC869 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
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HV
E
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N
P
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V
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T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
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D
M
A
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GD
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L
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A
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L
V
EEKADR
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L
D
--
--
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K
AL
E
D
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R
DARKGLD
D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
SHFAAD
DA
IF
T
C
DVG
TPTV
WAA
RYLKMNG
K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
LPVKI
I
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
ELHDT
NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|637388.3.peg.2650
Escherichia coli O157:H7 str. FRIK2000 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
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RECS
HY
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LV
SSP
E
Q
I
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L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
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P
G
DV
ALKPA--
----
P
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T
T
HWY
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QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
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A
G
A
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L
V
E
FAGKIKA
P
I
V
H
A
L
R
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HV
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P
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T
G
LI
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F
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M
M
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T
L
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LG
T
Q
F
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R
A------
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Y
P
T
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I
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--
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R
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A
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T
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K
R
RL
L
G
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F
NH
G
S
M
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P
Q
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QA
T
E
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RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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I
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NN
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LG
F
V
A
-
-
M
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M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
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V
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E
I
D
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AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|570506.3.peg.4379
Escherichia coli O157:H7 str. FRIK966 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
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N
P
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V
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T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
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PA
S
I
G
A
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D
M
A
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GD
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L
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L
V
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L
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--
--
-
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K
AL
E
D
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R
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D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
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DA
IF
T
C
DVG
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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I
VF
NN
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LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
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IR
V
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E
I
D
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AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|386585.9.peg.1073
Escherichia coli O157:H7 str. Sakai (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
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N
P
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V
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T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
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PA
S
I
G
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D
M
A
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L
R
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L
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--
--
-
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K
AL
E
D
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R
DARKGLD
D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
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DA
IF
T
C
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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VF
NN
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LG
F
V
A
-
-
M
E
M
KAGGYLTDG
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NF
AR
IA
E
A
C
G
IT
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IR
V
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E
I
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|544404.4.peg.984
Escherichia coli O157:H7 str. TW14359 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
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A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
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N
P
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V
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T
G
LI
G
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F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
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PA
S
I
G
A
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D
M
A
LV
GD
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L
R
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L
V
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L
D
--
--
-
-
K
AL
E
D
Y
R
DARKGLD
D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
SHFAAD
DA
IF
T
C
DVG
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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VF
NN
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LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|502346.5.peg.232
Escherichia coli O157:H7 str. TW14588 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
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----
P
EGA
T
T
HWY
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QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
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P
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V
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T
G
LI
G
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F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
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D
M
A
LV
GD
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L
R
A
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L
V
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KF
L
D
--
--
-
-
K
AL
E
D
Y
R
DARKGLD
D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
SHFAAD
DA
IF
T
C
DVG
TPTV
WAA
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
LPVKI
I
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|701177.3.peg.1089
Escherichia coli O55:H7 str. CB9615 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
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QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
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V
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T
G
LI
G
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F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
LV
GD
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L
R
A
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L
V
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L
D
--
--
-
-
K
AL
E
D
Y
R
DARKGLD
D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
SHFAAD
DA
IF
T
C
DVG
TPTV
WAA
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
LPVKI
I
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
E
AL
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|525281.3.peg.2081
Escherichia coli 83972 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
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C
GPG
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LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
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L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
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QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
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N
P
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V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
LV
GD
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L
R
A
LLP
L
V
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L
D
--
--
-
-
K
AL
E
D
Y
R
DARKGLD
D
LA
KPS
E
K
A
I
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L
AQQ
I
SHFAAD
DA
IF
T
C
DVG
TPTV
WAA
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
M
Q
M
K
LPVKI
I
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
ELHDT
NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|655817.3.peg.960
Escherichia coli ABU 83972 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
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LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
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T
T
HWY
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QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
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A
G
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L
V
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FAGKIKA
P
I
V
H
A
L
R
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HV
E
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N
P
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T
G
LI
G
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M
M
N
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T
L
VL
LG
T
Q
F
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R
A------
F
Y
P
T
D
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II
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N
PA
S
I
G
A
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D
M
A
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R
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L
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L
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--
--
-
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R
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D
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KPS
E
K
A
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L
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IF
T
C
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RYLKMNG
K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
M
Q
M
K
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I
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|199310.1.peg.977
Escherichia coli CFT073 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
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V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
LV
GD
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L
R
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L
V
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KF
L
D
--
--
-
-
K
AL
E
D
Y
R
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D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
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DA
IF
T
C
DVG
TPTV
WAA
RYLKMNG
K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
M
Q
M
K
LPVKI
I
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|199310.4.peg.957
Escherichia coli CFT073 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
YD
V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
LV
GD
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L
R
A
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L
V
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KF
L
D
--
--
-
-
K
AL
E
D
Y
R
DARKGLD
D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
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DA
IF
T
C
DVG
TPTV
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
M
Q
M
K
LPVKI
I
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
ELHDT
NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|749546.3.peg.4887
Escherichia coli MS 185-1 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
YD
V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
LV
GD
IKST
L
R
A
LLP
L
V
EEKTDR
KF
L
D
--
--
-
-
K
AL
E
D
Y
R
DARKGLD
D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
SHFAAD
DA
IF
T
C
DVG
TPTV
WAA
RYLKMNG
K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
M
Q
M
K
LPVKI
I
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
ELHDT
NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|749528.3.peg.4613
Escherichia coli MS 45-1 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
YD
V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
LV
GD
IKST
L
R
A
LLP
L
V
EEKTDR
KF
L
D
--
--
-
-
K
AL
E
D
Y
R
DARKGLD
D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
SHFAAD
DA
IF
T
C
DVG
TPTV
WAA
RYLKMNG
K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
M
Q
M
K
LPVKI
I
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
ELHDT
NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|155864.8.peg.979
Escherichia coli O157:H7 EDL933 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
X
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
YD
V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
LV
GD
IKST
L
R
A
LLP
L
V
EEKADR
KF
L
D
--
--
-
-
K
AL
E
D
Y
R
DARKGLD
D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
SHFAAD
DA
IF
T
C
DVG
TPTV
WAA
RYLKMNG
K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
LPVKI
I
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
ELHDT
NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|340186.3.peg.2513
Escherichia coli E110019 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
YD
V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
LV
GD
IKST
L
R
A
LLP
L
V
EEKADR
KF
L
D
--
--
-
-
K
AL
E
D
Y
R
DARKGLD
D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
SHFAAD
DA
IF
T
C
DVG
TPTV
WAA
RYLKMNG
K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
LPVKIV
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
ELHDT
NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
V
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|340186.5.peg.2597
Escherichia coli E110019 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
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V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
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GD
IKST
L
R
A
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L
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--
--
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AL
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D
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R
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LA
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A
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T
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K
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G
S
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P
Q
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QA
T
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RQ
VV
A
MC
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G
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M
L
M
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SV
V
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M
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NN
SV
LG
F
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-
M
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M
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T
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NF
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V
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|340185.3.peg.2782
Escherichia coli E22 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
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NLH
LI
N
G
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D
C
HR
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P
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L
A
I
A
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P
S
S
E
IG
S
GY
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T
H
PQ
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HY
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E
Q
I
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L
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A
M
RK
A
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LN
R
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V
V
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G
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ALKPA--
----
P
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T
T
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L
R
K
L
A
Q
L
L
RY
S
SN
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L
M
C
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G
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L
V
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H
A
L
R
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HV
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P
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T
G
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LG
T
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P
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K
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L
G
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G
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P
Q
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QA
T
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PE
RQ
VV
A
MC
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G
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M
L
M
GD
FL
SV
V
Q
M
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NN
SV
LG
F
V
A
-
-
M
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M
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T
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AR
IA
E
A
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V
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V
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AL
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|340185.4.peg.2932
Escherichia coli E22 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
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FAGKIKA
P
I
V
H
A
L
R
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KE
HV
E
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N
P
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V
GM
T
G
LI
G
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F
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M
M
N
AD
T
L
VL
LG
T
Q
F
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R
A------
F
Y
P
T
D
A
K
II
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PA
S
I
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M
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R
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D
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K
A
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L
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IF
T
C
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K
R
RL
L
G
S
F
NH
G
S
M
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P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
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V
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E
V
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|562.375.peg.4520
Escherichia coli EC4100B (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
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FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
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N
P
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V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
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N
PA
S
I
G
A
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D
M
A
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L
R
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L
V
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L
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--
--
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AL
E
D
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R
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D
LA
KPS
E
K
A
I
HPQY
L
AQQ
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DA
IF
T
C
DVG
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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VF
NN
SV
LG
F
V
A
-
-
M
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M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
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IR
V
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E
V
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|316401.4.peg.1083
Escherichia coli ETEC H10407 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
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ALKPA--
----
P
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T
T
HWY
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L
R
K
L
A
Q
L
L
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S
SN
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L
M
C
G
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G
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L
V
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P
I
V
H
A
L
R
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KE
HV
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P
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T
G
LI
G
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F
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M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
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PA
S
I
G
A
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D
M
A
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L
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L
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--
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AL
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D
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R
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D
LA
KPS
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K
A
I
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L
AQQ
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DA
IF
T
C
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
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IR
V
EKAS
E
V
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|331112.3.peg.904
Escherichia coli HS (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
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A
G
A
HKE
L
V
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FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
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V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
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D
M
A
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L
R
A
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L
V
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L
D
--
--
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AL
E
D
Y
R
DARKGLD
D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
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DA
IF
T
C
DVG
TPTV
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
V
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|331112.6.peg.943
Escherichia coli HS (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
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V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
LV
GD
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L
R
A
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L
V
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L
D
--
--
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AL
E
D
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R
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D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
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DA
IF
T
C
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
ELHDT
NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
V
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|749537.3.peg.4363
Escherichia coli MS 115-1 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
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HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
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VS
V
V
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P
G
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ALKPA--
----
P
EGA
T
T
HWY
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L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
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C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
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V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
LV
GD
IKST
L
R
A
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L
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D
--
--
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AL
E
D
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R
DARKGLD
D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
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DA
IF
T
C
DVG
TPTV
WAA
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
LPVKIV
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
ELHDT
NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
V
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|679205.4.peg.3836
Escherichia coli MS 124-1 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
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D
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fig|749533.3.peg.540
Escherichia coli MS 84-1 (4-535/572)
T
V
A
AY
I
A
KT
L
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A
GVK
R
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D
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fig|585395.4.peg.964
Escherichia coli O103:H2 str. 12009 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
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D
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fig|573235.3.peg.1019
Escherichia coli O26:H11 str. 11368 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
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D
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fig|409438.11.peg.1059
Escherichia coli SE11 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
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---
D
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fig|550676.3.peg.339
Escherichia coli B185 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
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---
D
GP
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LV
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P
fig|585396.4.peg.977
Escherichia coli O111:H- str. 11128 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
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V
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T
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---
D
GP
V
LV
D
V
V
VA
KE
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L
A
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P
fig|331111.12.peg.1235
Escherichia coli E24377A (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
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G
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L
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H
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HV
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T
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T
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---
D
GP
V
LV
D
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P
fig|331111.3.peg.3441
Escherichia coli E24377A (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
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LS
G
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L
AVC
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C
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LI
N
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D
C
HR
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P
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L
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I
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S
S
E
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T
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Q
I
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L
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M
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A
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V
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G
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----
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T
T
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L
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H
A
L
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T
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T
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A
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M
L
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V
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---
D
GP
V
LV
D
V
V
VA
KE
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L
A
I
P
fig|749545.3.peg.2513
Escherichia coli MS 182-1 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
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L
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C
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N
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LF
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C
HR
NHV
P
V
L
A
I
A
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P
S
S
E
IG
S
GY
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T
H
PQ
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HY
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LV
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E
Q
I
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L
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A
M
RK
A
V
LN
R
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VS
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V
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T
T
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L
R
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L
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Q
L
L
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L
M
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G
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G
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L
V
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I
V
H
A
L
R
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HV
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P
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G
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M
M
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T
L
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LG
T
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P
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T
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M
L
M
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V
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---
D
GP
V
LV
D
V
V
VA
KE
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L
A
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P
fig|749532.3.peg.867
Escherichia coli MS 78-1 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
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G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
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N
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D
C
HR
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P
V
L
A
I
A
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P
S
S
E
IG
S
GY
FQE
T
H
PQ
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HY
CE
LV
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E
Q
I
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L
AI
A
M
RK
A
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LN
R
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VS
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V
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----
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T
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R
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L
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L
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G
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L
V
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I
V
H
A
L
R
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HV
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P
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T
G
LI
G
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M
M
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AD
T
L
VL
LG
T
Q
F
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R
A------
F
Y
P
T
D
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K
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PA
S
I
G
A
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D
M
A
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L
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K
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IF
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K
R
RL
L
G
S
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NH
G
S
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P
Q
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QA
T
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RQ
VV
A
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M
L
M
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SV
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F
V
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V
D
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|656393.3.peg.1631
Escherichia coli H299 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
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G
T
I
E
W
M
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T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
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C
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LI
N
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D
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P
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L
A
I
A
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P
S
S
E
IG
S
GY
FQE
T
H
PQ
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HY
CE
LV
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E
Q
I
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L
AI
A
M
RK
A
V
LN
R
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V
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----
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T
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L
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V
H
A
L
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HV
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P
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T
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M
M
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T
L
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LG
T
Q
F
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R
A------
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Y
P
T
D
A
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PA
S
I
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D
M
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T
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K
R
RL
L
G
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F
NH
G
S
M
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P
Q
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QA
T
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PE
RQ
VV
A
MC
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G
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M
L
M
GD
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SV
V
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M
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NN
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F
V
A
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M
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M
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AR
IA
E
A
C
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V
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E
V
D
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---
D
GP
V
M
V
D
V
V
VA
KE
E
L
A
I
P
fig|656414.3.peg.1077
Escherichia coli H736 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
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M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
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C
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LI
N
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D
C
HR
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P
V
L
A
I
A
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P
S
S
E
IG
S
GY
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T
H
PQ
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HY
CE
LV
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E
Q
I
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L
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A
M
RK
A
V
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V
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R
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L
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L
M
C
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V
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P
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V
H
A
L
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HV
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P
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G
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F
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M
M
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T
L
VL
LG
T
Q
F
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R
A------
F
Y
P
T
D
A
K
II
Q
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N
PA
S
I
G
A
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D
M
A
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L
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--
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A
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IF
T
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K
R
RL
L
G
S
F
NH
G
S
M
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P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
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M
L
M
GD
FL
SV
V
Q
M
K
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NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
V
D
E
AL
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|749540.3.peg.2813
Escherichia coli MS 146-1 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
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LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
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RECS
HY
CE
LV
SSP
E
Q
I
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L
AI
A
M
RK
A
V
LN
R
-
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V
V
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P
G
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----
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TM
HWY
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L
R
K
L
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Q
L
L
RY
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I
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L
M
C
G
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G
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HKE
L
V
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FAGKIKA
P
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V
H
A
L
R
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KE
HV
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P
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V
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T
G
LI
G
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F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
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D
M
A
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D
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A
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IF
T
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
V
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|358709.5.peg.3171
Escherichia coli 101-1 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
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M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
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C
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LI
N
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D
C
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P
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L
A
I
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AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
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HY
CE
LV
SSP
E
Q
I
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L
AI
A
M
RK
A
V
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R
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V
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G
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----
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TM
HWY
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L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
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L
V
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P
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V
H
A
L
R
G
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HV
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P
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V
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T
G
LI
G
FSSG
F
HT
M
M
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AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
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II
Q
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PA
S
I
G
A
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D
M
A
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L
G
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G
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P
Q
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T
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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VF
NN
SV
LG
F
V
A
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-
M
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M
KAGGYLTDG
T
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NF
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E
A
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V
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E
V
D
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AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|670888.3.peg.1484
Escherichia coli 1827-70 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
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G
T
I
E
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M
S
T
RHE
E
V
A
AFA
A
G
A
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LS
G
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L
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C
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N
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D
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P
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L
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S
E
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T
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I
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L
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M
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A
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----
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TM
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R
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L
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HV
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T
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G
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P
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QA
T
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M
L
M
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SV
V
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M
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NN
SV
LG
F
V
A
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-
M
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M
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T
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NF
AR
IA
E
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V
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QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|344610.3.peg.3310
Escherichia coli 53638 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
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LF
D
C
HR
NHV
P
V
L
A
I
A
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P
S
S
E
IG
S
GY
FQE
T
H
PQ
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HY
CE
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E
Q
I
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L
AI
A
M
RK
A
V
LN
R
-
G
VS
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VL
P
G
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----
P
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TM
HWY
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L
R
K
L
A
Q
L
L
RY
S
SN
I
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L
M
C
G
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A
G
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V
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FAGKIKA
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V
H
A
L
R
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HV
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T
G
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M
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T
L
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LG
T
Q
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R
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P
T
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S
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A
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K
R
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L
G
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NH
G
S
M
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P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
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M
L
M
GD
FL
SV
V
Q
M
K
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NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
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IR
V
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E
V
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|344610.7.peg.808
Escherichia coli 53638 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
I
V
VL
P
G
DV
ALKPA--
----
P
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TM
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
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A
G
A
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L
V
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FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
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N
P
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T
G
LI
G
FSSG
F
HT
M
M
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AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
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PA
S
I
G
A
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D
M
A
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L
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L
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--
--
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AL
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D
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R
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D
LA
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K
A
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AQQ
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DA
IF
T
C
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
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M
L
M
GD
FL
SV
V
Q
M
K
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VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
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V
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E
V
D
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AL
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|481805.3.peg.2929
Escherichia coli ATCC 8739 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
TM
HWY
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QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
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A
G
A
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L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
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YD
N
P
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V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
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D
M
A
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L
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A
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L
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L
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--
--
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E
D
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R
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D
LA
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A
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L
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DA
IF
T
C
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K
R
RL
L
G
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F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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VF
NN
SV
LG
F
V
A
-
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M
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M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
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IR
V
EKAS
E
V
D
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AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|481805.6.peg.2919
Escherichia coli ATCC 8739 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
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ALKPA--
----
P
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TM
HWY
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L
R
K
L
A
Q
L
L
RY
S
SN
I
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L
M
C
G
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A
G
A
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L
V
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FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
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N
P
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V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
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D
M
A
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L
R
A
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L
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D
--
--
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D
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R
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D
LA
KPS
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K
A
I
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L
AQQ
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DA
IF
T
C
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
V
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|413997.3.peg.917
Escherichia coli B str. REL606 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
I
V
VL
P
G
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ALKPA--
----
P
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TM
HWY
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L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
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G
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A
G
A
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L
V
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FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
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V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
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D
M
A
LV
GD
IKST
L
R
A
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L
V
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L
D
--
--
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AL
E
D
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R
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D
LA
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E
K
A
I
HPQY
L
AQQ
I
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DA
IF
T
C
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
ELHDT
NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
V
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|511693.5.peg.942
Escherichia coli BL21 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
I
V
VL
P
G
DV
ALKPA--
----
P
EGA
TM
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
YD
V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
LV
GD
IKST
L
R
A
LLP
L
V
EEKADR
KF
L
D
--
--
-
-
K
AL
E
D
Y
R
DARKGLD
D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
SHFAAD
DA
IF
T
C
DVG
TPTV
WAA
RYLKMNG
K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
LPVKIV
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
ELHDT
NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
V
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|469008.4.peg.2821
Escherichia coli BL21(DE3) (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
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D
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fig|595496.3.peg.798
Escherichia coli BW2952 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
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G
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L
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V
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---
D
GP
V
LV
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V
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L
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P
fig|536056.3.peg.2925
Escherichia coli DH1 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
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L
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L
S
D
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L
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G
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I
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T
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V
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G
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L
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I
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S
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T
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A
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----
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R
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L
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H
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---
D
GP
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LV
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L
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P
fig|83333.1.peg.857
Escherichia coli K12 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
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G
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L
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T
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V
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A
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G
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L
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I
A
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S
S
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T
H
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LV
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E
Q
I
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A
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A
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L
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H
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L
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T
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P
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D
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P
Q
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T
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M
L
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---
D
GP
V
LV
D
V
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VA
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L
A
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P
fig|749538.3.peg.612
Escherichia coli MS 116-1 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
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L
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L
S
D
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L
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T
RHE
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V
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A
G
A
E
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G
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L
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D
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P
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L
A
I
A
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P
S
S
E
IG
S
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FQE
T
H
PQ
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HY
CE
LV
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E
Q
I
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L
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A
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A
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L
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H
A
L
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HV
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M
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T
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P
T
D
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IF
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K
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RL
L
G
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G
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P
Q
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QA
T
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RQ
VV
A
MC
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M
L
M
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M
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F
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NF
AR
IA
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A
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V
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V
D
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---
D
GP
V
LV
D
V
V
VA
KE
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L
A
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P
fig|749544.3.peg.2759
Escherichia coli MS 175-1 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
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G
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I
E
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M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
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AGS
C
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N
G
LF
D
C
HR
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P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
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HY
CE
LV
SSP
E
Q
I
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L
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A
M
RK
A
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V
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L
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L
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L
M
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H
A
L
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HV
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M
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T
L
VL
LG
T
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F
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P
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D
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S
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M
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A
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IF
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K
R
RL
L
G
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F
NH
G
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P
Q
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QA
T
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RQ
VV
A
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M
L
M
GD
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SV
V
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M
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F
V
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-
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M
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M
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AR
IA
E
A
C
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IR
V
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E
V
D
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
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P
fig|749547.3.peg.1573
Escherichia coli MS 187-1 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
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L
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L
S
D
S
L
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G
T
I
E
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M
S
T
RHE
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V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
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C
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N
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D
C
HR
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P
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L
A
I
A
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P
S
S
E
IG
S
GY
FQE
T
H
PQ
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HY
CE
LV
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E
Q
I
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L
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A
M
RK
A
V
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----
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TM
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L
R
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L
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Q
L
L
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S
SN
I
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L
M
C
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V
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FAGKIKA
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V
H
A
L
R
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HV
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P
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T
G
LI
G
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F
HT
M
M
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AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
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D
M
A
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L
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L
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--
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D
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D
LA
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A
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L
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I
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DA
IF
T
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
V
D
E
AL
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|749548.3.peg.3363
Escherichia coli MS 196-1 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
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G
T
I
E
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T
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V
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A
G
A
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LS
G
E
L
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D
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P
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L
A
I
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P
S
S
E
IG
S
GY
FQE
T
H
PQ
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HY
CE
LV
SSP
E
Q
I
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L
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A
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A
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R
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V
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TM
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L
R
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L
A
Q
L
L
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S
SN
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L
M
C
G
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L
V
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H
A
L
R
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HV
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P
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T
G
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G
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F
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M
M
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T
L
VL
LG
T
Q
F
PY
R
A------
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P
T
D
A
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II
Q
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PA
S
I
G
A
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QA
T
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RQ
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G
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L
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---
D
GP
V
LV
D
V
V
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L
A
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P
fig|316407.3.peg.838
Escherichia coli W3110 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
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G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
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A
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LS
G
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L
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C
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LI
N
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LF
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C
HR
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P
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L
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I
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S
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T
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I
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----
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TM
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T
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G
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QA
T
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RQ
VV
A
MC
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G
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M
L
M
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NN
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V
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-
M
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V
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|316385.7.peg.951
Escherichia coli str. K-12 substr. DH10B (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
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LI
N
G
LF
D
C
HR
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P
V
L
A
I
A
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P
S
S
E
IG
S
GY
FQE
T
H
PQ
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RECS
HY
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LV
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E
Q
I
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L
AI
A
M
RK
A
V
LN
R
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VS
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V
VL
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G
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----
P
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TM
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L
R
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L
A
Q
L
L
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SN
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L
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H
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L
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HV
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T
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M
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L
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LG
T
Q
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A------
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P
T
D
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S
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K
R
RL
L
G
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NH
G
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P
Q
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QA
T
E
PE
RQ
VV
A
MC
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G
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M
L
M
GD
FL
SV
V
Q
M
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NN
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F
V
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-
-
M
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M
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NF
AR
IA
E
A
C
G
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V
D
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|511145.12.peg.900
Escherichia coli str. K-12 substr. MG1655 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
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LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
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RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
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VS
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V
VL
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G
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----
P
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TM
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QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
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SN
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M
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G
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V
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V
H
A
L
R
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HV
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T
G
LI
G
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M
M
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T
L
VL
LG
T
Q
F
PY
R
A------
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Y
P
T
D
A
K
II
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PA
S
I
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D
M
A
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R
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D
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IF
T
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K
R
RL
L
G
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F
NH
G
S
M
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P
Q
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QA
T
E
PE
RQ
VV
A
MC
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G
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M
L
M
GD
FL
SV
V
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NN
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F
V
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M
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M
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IA
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V
D
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
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P
fig|511145.6.peg.893
Escherichia coli str. K-12 substr. MG1655 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
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C
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LI
N
G
LF
D
C
HR
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P
V
L
A
I
A
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P
S
S
E
IG
S
GY
FQE
T
H
PQ
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RECS
HY
CE
LV
SSP
E
Q
I
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L
AI
A
M
RK
A
V
LN
R
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V
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----
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TM
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L
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L
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L
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M
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V
H
A
L
R
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HV
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T
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M
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T
L
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LG
T
Q
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R
A------
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P
T
D
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PA
S
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M
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L
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R
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D
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IF
T
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K
R
RL
L
G
S
F
NH
G
S
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P
Q
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QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
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SV
V
Q
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F
V
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-
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M
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IA
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C
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E
V
D
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|340184.3.peg.1276
Escherichia coli B7A (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
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C
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LI
N
G
LF
D
C
HR
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P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
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HY
CE
LV
SSP
E
Q
I
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L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
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P
G
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----
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T
T
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L
R
K
L
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Q
L
L
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SN
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L
M
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G
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L
V
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P
I
V
H
A
L
R
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HV
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P
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T
G
LI
G
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F
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M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
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K
II
Q
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PA
S
I
G
A
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D
M
A
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L
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L
V
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--
--
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D
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D
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A
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IF
T
C
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
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IR
V
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E
V
D
E
AL
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|340184.6.peg.1342
Escherichia coli B7A (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
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C
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N
G
LF
D
C
HR
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P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
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RECS
HY
CE
LV
SSP
E
Q
I
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L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
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P
G
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----
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T
T
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L
R
K
L
A
Q
L
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L
M
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G
A
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L
V
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P
I
V
H
A
L
R
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KE
HV
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P
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T
G
LI
G
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M
M
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AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
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PA
S
I
G
A
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D
M
A
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--
--
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D
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K
A
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IF
T
C
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
V
D
E
AL
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|656408.3.peg.928
Escherichia coli H591 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
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C
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LI
N
G
LF
D
C
HR
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P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
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HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
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G
VS
V
V
VL
P
G
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----
P
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T
T
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L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
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G
A
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L
V
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FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
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N
P
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V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
LV
GD
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L
R
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L
V
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L
D
--
--
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AL
E
D
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R
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D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
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DA
IF
T
C
DVG
TPTV
WAA
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
LPVKIV
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
ELHDT
NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
V
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|585034.4.peg.900
Escherichia coli IAI1 (4-535/572)
T
V
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L
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GVK
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---
D
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P
fig|585034.5.peg.896
Escherichia coli IAI1 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
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L
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L
S
D
S
L
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V
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G
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T
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R
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---
D
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L
A
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P
fig|595495.4.peg.3381
Escherichia coli KO11 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
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L
NG
L
S
D
S
L
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G
T
I
E
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M
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T
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V
A
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A
G
A
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A
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LS
G
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L
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L
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I
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S
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T
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T
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R
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L
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M
L
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---
D
GP
V
LV
D
V
V
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L
A
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P
fig|679207.4.peg.2035
Escherichia coli MS 107-1 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
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L
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L
S
D
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L
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G
T
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T
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V
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A
G
A
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G
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P
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L
A
I
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S
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T
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I
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T
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L
R
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H
A
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HV
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T
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P
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D
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K
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T
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M
L
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
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P
fig|679206.4.peg.3777
Escherichia coli MS 119-7 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
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L
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L
S
D
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G
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I
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V
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A
G
A
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A
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G
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L
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P
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L
A
I
A
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S
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S
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T
H
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Q
I
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A
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T
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L
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H
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T
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D
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G
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T
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RQ
VV
A
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M
L
M
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SV
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F
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V
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|679204.3.peg.2467
Escherichia coli MS 145-7 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
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L
S
D
S
L
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G
T
I
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M
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T
RHE
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V
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A
G
A
E
A
Q
LS
G
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L
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D
C
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P
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L
A
I
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P
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S
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T
H
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Q
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A
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V
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T
T
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L
R
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L
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V
H
A
L
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HV
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P
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T
G
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M
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AD
T
L
VL
LG
T
Q
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R
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F
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P
T
D
A
K
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PA
S
I
G
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D
M
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D
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R
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D
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A
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K
R
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L
G
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F
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G
S
M
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P
Q
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QA
T
E
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RQ
VV
A
MC
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M
L
M
GD
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SV
V
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M
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F
V
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AR
IA
E
A
C
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V
D
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
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P
fig|656443.3.peg.1154
Escherichia coli TA271 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
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G
T
I
E
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M
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T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
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C
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D
C
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P
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L
A
I
A
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P
S
S
E
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S
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T
H
PQ
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HY
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E
Q
I
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L
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A
M
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A
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V
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----
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T
T
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L
R
K
L
A
Q
L
L
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SN
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L
M
C
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G
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L
V
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P
I
V
H
A
L
R
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HV
E
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P
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V
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T
G
LI
G
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F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
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N
PA
S
I
G
A
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D
M
A
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--
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D
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A
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T
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
V
D
E
AL
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|566546.3.peg.1907
Escherichia coli W (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
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C
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LI
N
G
LF
D
C
HR
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P
V
L
A
I
A
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P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
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HY
CE
LV
SSP
E
Q
I
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L
AI
A
M
RK
A
V
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R
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G
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V
V
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P
G
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P
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T
T
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L
R
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L
A
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RY
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SN
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M
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M
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L
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LG
T
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T
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QA
T
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M
L
M
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LG
F
V
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-
M
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T
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V
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
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P
fig|566546.4.peg.969
Escherichia coli W (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
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L
AVC
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C
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LI
N
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LF
D
C
HR
NHV
P
V
L
A
I
A
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S
S
E
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S
GY
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T
H
PQ
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HY
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LV
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Q
I
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L
AI
A
M
RK
A
V
LN
R
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G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
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T
T
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L
R
K
L
A
Q
L
L
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SN
I
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L
M
C
G
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G
A
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L
V
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V
H
A
L
R
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HV
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T
G
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M
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T
L
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LG
T
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R
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Y
P
T
D
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S
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G
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P
Q
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QA
T
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PE
RQ
VV
A
MC
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G
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M
L
M
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FL
SV
V
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LG
F
V
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-
-
M
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M
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IA
E
A
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V
D
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|405955.13.peg.834
Escherichia coli APEC O1 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
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LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
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ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
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L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
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N
P
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V
GM
T
G
LI
G
FSSG
F
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M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
V------
F
Y
P
T
D
A
K
II
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PA
S
I
G
A
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M
A
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R
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A
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IF
T
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K
R
RL
L
G
S
F
NH
G
S
M
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P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
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M
L
M
GD
FL
SV
V
Q
M
K
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F
V
A
-
-
M
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M
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NF
AR
IA
E
A
C
G
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V
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E
I
D
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QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|405955.9.peg.702
Escherichia coli APEC O1 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
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RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
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ALKPA--
----
P
EGA
T
T
HWY
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QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
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L
M
C
G
S
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G
A
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L
V
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FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
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N
P
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T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
V------
F
Y
P
T
D
A
K
II
Q
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N
PA
S
I
G
A
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D
M
A
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D
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R
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D
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A
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L
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DA
IF
T
C
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K
R
RL
L
G
S
F
NH
G
S
M
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P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
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M
L
M
GD
FL
SV
V
Q
M
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F
V
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M
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M
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NF
AR
IA
E
A
C
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IR
V
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E
I
D
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|714962.3.peg.880
Escherichia coli IHE3034 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
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G
T
I
E
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T
RHE
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V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
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C
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N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
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HY
CE
LV
SSP
E
Q
I
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L
AI
A
M
RK
A
V
LN
R
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V
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----
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T
T
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L
R
K
L
A
Q
L
L
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SN
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L
M
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G
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G
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V
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P
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V
H
A
L
R
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HV
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P
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T
G
LI
G
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F
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M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
V------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
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D
M
A
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D
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R
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D
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A
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L
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DA
IF
T
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K
R
RL
L
G
S
F
NH
G
S
M
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P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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LG
F
V
A
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M
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M
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T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
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AL
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|753642.3.peg.742
Escherichia coli NC101 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
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C
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LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
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HY
CE
LV
SSP
E
Q
I
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L
AI
A
M
RK
A
V
LN
R
-
G
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V
V
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P
G
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----
P
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T
T
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L
R
K
L
A
Q
L
L
RY
S
SN
I
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L
M
C
G
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G
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L
V
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P
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V
H
A
L
R
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HV
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P
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T
G
LI
G
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F
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M
M
N
AD
T
L
VL
LG
T
Q
F
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R
V------
F
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P
T
D
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K
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Q
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PA
S
I
G
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D
M
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D
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R
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D
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A
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L
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DA
IF
T
C
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|585035.6.peg.893
Escherichia coli S88 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
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M
S
T
RHE
E
V
A
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A
G
A
E
A
Q
LS
G
E
L
AVC
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C
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LI
N
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LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
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HY
CE
LV
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E
Q
I
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L
AI
A
M
RK
A
V
LN
R
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V
V
VL
P
G
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----
P
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T
T
HWY
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L
R
K
L
A
Q
L
L
RY
S
SN
I
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L
M
C
G
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G
A
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L
V
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P
I
V
H
A
L
R
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HV
E
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P
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T
G
LI
G
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F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
V------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
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D
M
A
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L
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L
V
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L
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--
--
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AL
E
D
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R
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D
LA
KPS
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K
A
I
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L
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DA
IF
T
C
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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I
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
ELHDT
NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
I
D
E
AL
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|431946.3.peg.834
Escherichia coli SE15 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
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C
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LI
N
G
LF
D
C
HR
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P
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L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
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HY
CE
LV
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E
Q
I
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L
AI
A
M
RK
A
V
LN
R
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V
V
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P
G
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----
P
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T
T
HWY
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L
R
K
L
A
Q
L
L
RY
S
SN
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L
M
C
G
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L
V
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P
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V
H
A
L
R
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HV
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P
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T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
V------
F
Y
P
T
D
A
K
II
Q
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N
PA
S
I
G
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M
A
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G
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F
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M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
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M
L
M
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SV
V
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F
V
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-
M
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M
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T
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NF
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E
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V
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I
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---
D
GP
V
LV
D
V
V
VA
KE
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L
A
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P
fig|869729.3.peg.2839
Escherichia coli UM146 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
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LS
G
E
L
AVC
AGS
C
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NLH
LI
N
G
LF
D
C
HR
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P
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L
A
I
A
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P
S
S
E
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S
GY
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T
H
PQ
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HY
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LV
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E
Q
I
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L
AI
A
M
RK
A
V
LN
R
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G
VS
V
V
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P
G
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ALKPA--
----
P
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T
T
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L
R
K
L
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L
L
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S
SN
I
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L
M
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P
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H
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L
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HV
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T
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G
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P
Q
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QA
T
E
PE
RQ
VV
A
MC
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G
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M
L
M
GD
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SV
V
Q
M
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LG
F
V
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-
-
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M
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IA
E
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I
D
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|364106.7.peg.961
Escherichia coli UTI89 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
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HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
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ALKPA--
----
P
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T
T
HWY
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QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
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G
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L
V
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FAGKIKA
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I
V
H
A
L
R
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HV
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P
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G
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G
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T
L
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LG
T
Q
F
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R
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P
T
D
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S
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K
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RL
L
G
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F
NH
G
S
M
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P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
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M
L
M
GD
FL
SV
V
Q
M
K
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VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
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NF
AR
IA
E
A
C
G
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V
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E
I
D
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AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|364106.8.peg.960
Escherichia coli UTI89 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
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L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
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N
P
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V
GM
T
G
LI
G
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F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
V------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
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M
A
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R
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L
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L
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--
--
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D
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R
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D
LA
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A
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L
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IF
T
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K
R
RL
L
G
S
F
NH
G
S
M
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P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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F
V
A
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-
M
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M
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NF
AR
IA
E
A
C
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E
I
D
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AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|562.376.peg.4731
Escherichia coli WV_060327 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
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ALKPA--
----
P
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T
T
HWY
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QPVVTPEEEE
L
R
K
L
A
Q
L
L
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S
SN
I
A
L
M
C
G
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G
A
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L
V
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FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
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N
P
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T
G
LI
G
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F
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M
M
N
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T
L
VL
LG
T
Q
F
PY
R
V------
F
Y
P
T
D
A
K
II
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N
PA
S
I
G
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D
M
A
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--
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R
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D
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A
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IF
T
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K
R
RL
L
G
S
F
NH
G
S
M
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P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
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G
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M
L
M
GD
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SV
V
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M
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F
V
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M
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AR
IA
E
A
C
G
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V
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E
I
D
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|656444.3.peg.1482
Escherichia coli TA280 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
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C
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N
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D
C
HR
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P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
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RECS
HY
CE
LV
SSP
E
Q
I
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L
AI
A
M
RK
A
V
LN
R
-
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V
V
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P
G
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----
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T
T
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L
R
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L
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L
L
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SN
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L
M
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G
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L
V
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P
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V
H
A
L
R
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HV
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P
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G
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M
M
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T
L
VL
LG
T
Q
F
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R
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P
T
D
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S
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M
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T
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K
R
RL
L
G
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F
NH
G
S
M
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P
Q
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QA
T
E
PE
RQ
VV
A
MC
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G
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M
L
M
GD
FL
SV
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M
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F
V
A
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M
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M
KAGGYLTDG
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NF
AR
IA
E
A
C
G
IT
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V
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E
I
D
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|6666666.5357.peg.3854
Escherichia coli TY-2482 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
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G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
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N
G
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D
C
HR
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P
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L
A
I
A
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P
S
S
E
IG
S
GY
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T
H
PQ
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HY
CE
LV
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E
Q
I
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L
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A
M
RK
A
V
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R
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V
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----
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T
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L
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L
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L
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M
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G
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P
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H
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L
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M
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T
L
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LG
T
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R
A------
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P
T
D
A
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PA
S
I
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T
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K
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RL
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G
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F
NH
G
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M
ANAM
P
Q
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QA
T
E
PE
RQ
VV
A
MC
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G
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M
L
M
GD
FL
SV
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Q
M
K
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NN
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LG
F
V
A
-
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M
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M
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T
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NF
AR
IA
E
A
C
G
IT
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IR
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E
V
D
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---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|585055.6.peg.930
Escherichia coli 55989 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
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M
S
T
RHE
E
V
A
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A
G
A
E
A
Q
LS
G
E
L
AVC
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C
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LI
N
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D
C
HR
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P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
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HY
CE
LV
SSP
E
Q
I
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L
AI
A
M
RK
A
V
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R
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V
V
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P
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T
T
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L
R
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L
A
Q
L
L
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S
SN
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L
M
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A
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L
V
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P
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H
A
L
R
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HA
E
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P
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T
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LI
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M
M
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AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
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D
M
A
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L
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--
--
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D
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R
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D
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E
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A
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L
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DA
IF
T
C
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K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
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VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
ELHDT
NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
V
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|585055.8.peg.933
Escherichia coli 55989 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HA
E
YD
N
P
YD
V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
A------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
LV
GD
IKST
L
R
A
LLP
L
V
EEKTDR
KF
L
D
--
--
-
-
K
AL
E
D
Y
R
DARKGLD
D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
SHFAAD
DA
IF
T
C
DVG
TPTV
WAA
RYLKMNG
K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
LPVKIV
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
ELHDT
NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
V
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|670897.3.peg.4715
Escherichia coli 2362-75 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
YD
V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
V------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
T
HSKV
D
M
A
LV
GD
IKST
L
R
A
LLP
L
V
EEKTER
KF
L
D
--
--
-
-
K
AL
E
D
Y
R
DARKGLD
D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
SHFAAD
DA
IF
T
C
DVG
TPTV
WAA
RYLKMNG
K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
LPVKIV
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
ELHDT
NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
V
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
fig|216593.1.peg.1517
Escherichia coli E2348/69 (4-535/572)
T
V
A
AY
I
A
KT
L
ES
A
GVK
R
I
W
G
V
T
G
D
S
L
NG
L
S
D
S
L
NRM
G
T
I
E
W
M
S
T
RHE
E
V
A
AFA
A
G
A
E
A
Q
LS
G
E
L
AVC
AGS
C
GPG
NLH
LI
N
G
LF
D
C
HR
NHV
P
V
L
A
I
A
AHI
P
S
S
E
IG
S
GY
FQE
T
H
PQ
ELF
RECS
HY
CE
LV
SSP
E
Q
I
PQV
L
AI
A
M
RK
A
V
LN
R
-
G
VS
V
V
VL
P
G
DV
ALKPA--
----
P
EGA
T
T
HWY
HAP
QPVVTPEEEE
L
R
K
L
A
Q
L
L
RY
S
SN
I
A
L
M
C
G
S
G
C--
A
G
A
HKE
L
V
E
FAGKIKA
P
I
V
H
A
L
R
G
KE
HV
E
YD
N
P
YD
V
GM
T
G
LI
G
FSSG
F
HT
M
M
N
AD
T
L
VL
LG
T
Q
F
PY
R
V------
F
Y
P
T
D
A
K
II
Q
IDI
N
PA
S
I
G
A
HSKV
D
M
A
LV
GD
IKST
L
R
A
LLP
L
V
EEKTER
KF
L
D
--
--
-
-
K
AL
E
D
Y
R
DARKGLD
D
LA
KPS
E
K
A
I
HPQY
L
AQQ
I
SHFAAD
DA
IF
T
C
DVG
TPTV
WAA
RYLKMNG
K
R
RL
L
G
S
F
NH
G
S
M
ANAM
P
Q
ALGA
QA
T
E
PE
RQ
VV
A
MC
GDG
G
FS
M
L
M
GD
FL
SV
V
Q
M
K
LPVKIV
VF
NN
SV
LG
F
V
A
-
-
M
E
M
KAGGYLTDG
T
ELHDT
NF
AR
IA
E
A
C
G
IT
G
IR
V
EKAS
E
V
D
E
AL
QRAFSI
---
D
GP
V
LV
D
V
V
VA
KE
E
L
A
I
P
Consen1
Primary consensus
MASSGTtSTRKRftgA
iv
L
qGvk
v
G
pGgsi
vyDaL
g
i
hil
RHEq
A
A
g
Ar
Gk
aVc
sGPGatnlitgiada
dsiPlv
itgqv
as
IG
daFQE
d
gis
kh
LV
EelPqvm
Af
A
sgRpGpv
vdiPkDv
----
e
tm
---
ir
a
q
l
a
p
ly
GgG
A
a
l
E
P
t
tL
glg
p
hp
lGMlGmhG
n
m
eaD
l
lG
rFddR
f
P
-
nA
iihiDIdpaei
k
hvaiqgD
L
qllp
v
qpl
--
w
q
ad
r
d
--
d
-
i
l
l
da
T
DVGqhqmwaA
pr
l
S
glGtMgfglPaAlGa
a
Pe
Vvc
GDGs
Mniqe
ta
q
qLpvkiv
nN
LG
V
q
q
l
t
nF
iA
a
G
g
i
e
e
aL
---
gp
lvhV
id
E
v
PmvppGa
n
EMvGE
Consen2
Secondary consensus
s
lsv
va
a
in
i
t
da
s
s
t
v
w
s
e
a
q
e
g
v
c
nlhavnalftc
nhv
v
l
ahi
p
gy
h
elf
hy
i
ril
m
ln
-
vs
ivl
g
i
pyvwp
t
hap
l
a
i
s
i
vm
s
c
v
v
ake
e
r
v
t
li
f
nc
i
v
q
py
y
t
vlq
nrts
a
d
plva
amie
l
kfr
ei
-
k
eq
q
pla
e
al
v
nc
tptvft
ke
i
nh
s
anam
q
v
t
la
g
l
gd
sv
dllvi
d
-
m
m
y
d
l
g
t
k
vrn
rl
f
d
va
a
lqir
g
m
l
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character