fig|585057.4.peg.4327
Escherichia coli IAI39
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
N
Y
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|585057.6.peg.4336
Escherichia coli IAI39
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
N
Y
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|316385.5.peg.3791
Escherichia coli str. K-12 substr. DH10B (16-475/475)
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|216592.1.peg.972
Escherichia coli 042 (20-479/479)
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|344610.3.peg.1909
Escherichia coli 53638 (20-479/479)
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|481805.3.peg.56
Escherichia coli ATCC 8739 (20-479/479)
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|340184.3.peg.2908
Escherichia coli B7A (20-479/479)
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|340185.3.peg.2132
Escherichia coli E22 (20-479/479)
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|331111.3.peg.1803
Escherichia coli E24377A (20-479/479)
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|331112.3.peg.3626
Escherichia coli HS (20-479/479)
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|344601.3.peg.2457
Escherichia coli B171 (20-479/479)
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
V
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|478005.5.peg.353
Escherichia coli O157:H7 str. EC4486 (16-475/475)
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
NF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
L
C
GA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|199310.1.peg.4395
Escherichia coli CFT073 (20-479/479)
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|155864.1.peg.4546
Escherichia coli O157:H7 EDL933 (20-479/479)
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
NF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
L
C
GA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|216593.1.peg.4425
Escherichia coli E2348/69 (20-479/479)
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SV
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|340197.3.peg.503
Escherichia coli F11 (20-479/479)
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SV
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|1040638.4.peg.1538
Escherichia coli O104:H4 str. LB226692
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|6666666.5357.peg.4660
Escherichia coli TY-2482
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|216592.3.peg.4141
Escherichia coli 042
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|358709.5.peg.131
Escherichia coli 101-1
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|344610.7.peg.2543
Escherichia coli 53638
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|585055.6.peg.4155
Escherichia coli 55989
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|585055.8.peg.4158
Escherichia coli 55989
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|481805.6.peg.58
Escherichia coli ATCC 8739
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|550672.3.peg.3726
Escherichia coli B088
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|550677.3.peg.4232
Escherichia coli B354
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|340184.6.peg.3043
Escherichia coli B7A
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|595496.3.peg.3659
Escherichia coli BW2952
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|536056.3.peg.50
Escherichia coli DH1
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|340185.4.peg.2261
Escherichia coli E22
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|331111.12.peg.4401
Escherichia coli E24377A
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|562.375.peg.344
Escherichia coli EC4100B
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|316401.4.peg.4428
Escherichia coli ETEC H10407
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|656408.3.peg.4110
Escherichia coli H591
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|656414.3.peg.4178
Escherichia coli H736
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|331112.6.peg.3780
Escherichia coli HS
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|585034.4.peg.3748
Escherichia coli IAI1
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|585034.5.peg.3745
Escherichia coli IAI1
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|83333.1.peg.3593
Escherichia coli K12
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|595495.4.peg.3576
Escherichia coli KO11
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|656419.3.peg.4692
Escherichia coli M718
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|679207.4.peg.116
Escherichia coli MS 107-1
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|749537.3.peg.3299
Escherichia coli MS 115-1
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|749538.3.peg.3210
Escherichia coli MS 116-1
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|679206.4.peg.2203
Escherichia coli MS 119-7
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|679205.4.peg.2408
Escherichia coli MS 124-1
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|679204.3.peg.4663
Escherichia coli MS 145-7
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|749544.3.peg.1180
Escherichia coli MS 175-1
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|749545.3.peg.1586
Escherichia coli MS 182-1
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|749548.3.peg.4119
Escherichia coli MS 196-1
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|749532.3.peg.413
Escherichia coli MS 78-1
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|749533.3.peg.5329
Escherichia coli MS 84-1
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|585395.4.peg.4709
Escherichia coli O103:H2 str. 12009
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|585396.4.peg.4639
Escherichia coli O111:H- str. 11128
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|573235.3.peg.5090
Escherichia coli O26:H11 str. 11368
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|409438.11.peg.4113
Escherichia coli SE11
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|656443.3.peg.4591
Escherichia coli TA271
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|566546.3.peg.4128
Escherichia coli W
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|566546.4.peg.3896
Escherichia coli W
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|316407.3.peg.3471
Escherichia coli W3110
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|316385.7.peg.3877
Escherichia coli str. K-12 substr. DH10B
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|511145.12.peg.3777
Escherichia coli str. K-12 substr. MG1655
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|511145.6.peg.3759
Escherichia coli str. K-12 substr. MG1655
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|656379.3.peg.4500
Escherichia coli FVEC1302
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|656380.3.peg.4782
Escherichia coli FVEC1412
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|749549.3.peg.166
Escherichia coli MS 198-1
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|749527.3.peg.3909
Escherichia coli MS 21-1
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|439855.10.peg.4138
Escherichia coli SMS-3-5
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|656444.3.peg.4973
Escherichia coli TA280
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|585056.7.peg.4348
Escherichia coli UMN026
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|550676.3.peg.3852
Escherichia coli B185
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
VAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|405955.9.peg.3445
Escherichia coli APEC O1 (20-479/479)
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKF
Q
P
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SV
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|749531.3.peg.918
Escherichia coli MS 69-1
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
G
S
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|656437.3.peg.4120
Escherichia coli TA143
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
S
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|670888.3.peg.2565
Escherichia coli 1827-70
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
M
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|656393.3.peg.4758
Escherichia coli H299
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|340186.3.peg.3583
Escherichia coli E110019 (20-479/479)
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
W
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
S
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|749540.3.peg.943
Escherichia coli MS 146-1
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
IY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|344601.5.peg.2560
Escherichia coli B171
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
V
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|525281.3.peg.3140
Escherichia coli 83972
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|655817.3.peg.4310
Escherichia coli ABU 83972
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|656417.3.peg.4539
Escherichia coli M605
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|749546.3.peg.1425
Escherichia coli MS 185-1
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|749528.3.peg.2929
Escherichia coli MS 45-1
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|431946.3.peg.3648
Escherichia coli SE15
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|413997.3.peg.3693
Escherichia coli B str. REL606
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
R
R
GKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|511693.5.peg.3711
Escherichia coli BL21
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
R
R
GKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|469008.4.peg.71
Escherichia coli BL21(DE3)
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
R
R
GKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|749547.3.peg.279
Escherichia coli MS 187-1
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
R
R
GKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|637912.3.peg.608
Escherichia coli OP50
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
R
R
GKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|585397.7.peg.4344
Escherichia coli ED1a
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
ILFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|585397.9.peg.4341
Escherichia coli ED1a
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
ILFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|656440.3.peg.3969
Escherichia coli TA206
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
S
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|562.371.peg.3135
Escherichia coli 1044A
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
NF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
L
C
GA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|562.373.peg.1523
Escherichia coli 1125A
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
NF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
L
C
GA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|562.372.peg.4018
Escherichia coli 1212A
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
NF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
L
C
GA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|562.374.peg.1142
Escherichia coli 536A
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
NF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
L
C
GA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|83334.1.peg.4505
Escherichia coli O157:H7
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
NF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
L
C
GA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|155864.8.peg.4510
Escherichia coli O157:H7 EDL933
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
NF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
L
C
GA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|444454.5.peg.3636
Escherichia coli O157:H7 str. EC4024
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
NF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
L
C
GA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|444449.5.peg.3090
Escherichia coli O157:H7 str. EC4042
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
NF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
L
C
GA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|444448.5.peg.1845
Escherichia coli O157:H7 str. EC4045
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
NF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
L
C
GA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|444453.5.peg.1375
Escherichia coli O157:H7 str. EC4076
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
NF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
L
C
GA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|444452.5.peg.1724
Escherichia coli O157:H7 str. EC4113
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
NF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
L
C
GA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|444450.8.peg.4926
Escherichia coli O157:H7 str. EC4115
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
NF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
L
C
GA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|444451.5.peg.140
Escherichia coli O157:H7 str. EC4196
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
NF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
L
C
GA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|444447.5.peg.2009
Escherichia coli O157:H7 str. EC4206
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
NF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
L
C
GA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|478004.5.peg.401
Escherichia coli O157:H7 str. EC4401
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
NF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
L
C
GA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|478006.5.peg.389
Escherichia coli O157:H7 str. EC4501
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
NF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
L
C
GA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|478007.5.peg.1448
Escherichia coli O157:H7 str. EC508
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
NF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
L
C
GA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|478008.5.peg.897
Escherichia coli O157:H7 str. EC869
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
NF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
L
C
GA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|637388.3.peg.1231
Escherichia coli O157:H7 str. FRIK2000
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
NF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
L
C
GA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|570506.3.peg.596
Escherichia coli O157:H7 str. FRIK966
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
NF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
L
C
GA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|386585.9.peg.4751
Escherichia coli O157:H7 str. Sakai
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
NF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
L
C
GA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|544404.4.peg.4737
Escherichia coli O157:H7 str. TW14359
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
NF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
L
C
GA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|502346.5.peg.2070
Escherichia coli O157:H7 str. TW14588
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
NF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
L
C
GA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|199310.4.peg.4215
Escherichia coli CFT073
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFX-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|562.376.peg.2568
Escherichia coli WV_060327
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TAT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|670897.3.peg.3641
Escherichia coli 2362-75
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SV
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|362663.8.peg.3800
Escherichia coli 536
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SV
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|362663.9.peg.3814
Escherichia coli 536
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SV
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|340197.5.peg.522
Escherichia coli F11
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SV
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|714962.3.peg.4148
Escherichia coli IHE3034
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SV
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|749550.3.peg.2291
Escherichia coli MS 200-1
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SV
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|753642.3.peg.4266
Escherichia coli NC101
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SV
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|685038.3.peg.3724
Escherichia coli O83:H1 str. NRG 857C
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SV
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|585035.6.peg.4009
Escherichia coli S88
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SV
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|869729.3.peg.3963
Escherichia coli UM146
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SV
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|364106.7.peg.4115
Escherichia coli UTI89
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SV
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|364106.8.peg.4117
Escherichia coli UTI89
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SV
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|405955.13.peg.4114
Escherichia coli APEC O1
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKF
Q
P
W
V
LFGA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SV
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|701177.3.peg.4423
Escherichia coli O55:H7 str. CB9615
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
NF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
L
A
D
R
-
--TRS
RWGKFRP
W
V
L
C
GA
L
P
FG
I
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
V
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RE
D
L
RD
I
WQ
N
D
QW
R
I
VGL
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
S
YV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|340186.5.peg.3737
Escherichia coli E110019
MKSEVL
SV
KEKI
G
YGMGD
A
AS
H
II
F
DN
V
M
LY
MM
F
FYTD
IF
GIPA
GFV
GTMFLV
A
R
A
L
DA
I
S
D
PCM
G
L
W
A
D
R
-
--TRS
RWGKFRP
W
V
LFGA
L
P
FG
S
VCV
L
A
Y
-
ST
P
DLSMNG
K
MIY
A
AI
TY
T
LL
T
L
L
Y
T
I
VNIPY
C
AL
GG
V
IT
ND
P
TQ
R
I
S
L
Q
S
W
R
FV
L
AT
A
G
G
MLS
TV
L
M
M
--
P
LVN
L
IGG
D
NKPLG
F
QGGIA
VLS
V
V
A
F
M
MLAF
CF
FT
TKE
R-
-
V
EAP
P
TTT----
S
M
RD
D
L
RD
I
WQ
N
D
QW
R
I
VG
F
L
T
I
F
N
IL
A
V
-
C-
-
-
V
RG
G
AM
M
YYV
T
WI
L
GT
PEVFV-A
-
F
L
T
TY
C
V
-
G
NLIG
SA
----
L
A
K
PL
T
DWK
C
K
V
TI
F
WW
T
NA
L
LAV
I
S
L
A
M
FF
VPMQA
S
IT
MF
V
FI
F
VIGV
L
H
QL
V
----TP
I
Q
W
VM
MS
DTVDYGEW
C
N
G
K
R
L
T
G
IS
F
A
G
TL
F
V
L
K
L
G
L
A
F
GG
AL
I
G
W
ML
AYG
GY
D
A
A
EK
A
QN
SA
TI
S
I
I
I
A
L
F
T
I
V
P
AICY
LL
S
A
I
IAKR
Y
Y
S
LT
T
H
NLKT
V
M
E
QL
AQ
G
K
RR
CQQQFTSQEVQN
fig|83333.1.peg.266
Escherichia coli K12 (4-440/460)
L
TM
K
D
KI
G
YG
L
GD
T
A
CG
FV
W
QA
T
M
FL
L
A
Y
FYTD
VF
G
L
S
A
GIM
GT
L
FLV
S
R
V
L
DA
V
TD
PLM
G
L
L
V
D
R
-
--TRT
R
H
G
Q
FRPF
L
L
W
GA
I
P
FG
I
VCV
L
T
F
-
YT
P
DFSAQG
K
IIY
A
CV
TY
I
LL
T
L
V
Y
T
F
VN
V
PY
C
A
M
PG
V
IT
AD
P
KE
R
H
A
L
Q
S
W
R
FF
L
A
A
A
G
S
LAI
S
G
I
A
L
--
P
LVS
I
IGK
G
DEQVG
Y
FGAMC
VL
G
L
S
G
V
V
LLYV
CF
FT
TKE
RY
TF
EVQ
P
-GS----
S
V
AK
D
L
KL
L
LG
N
S
QW
R
I
---
M
C
A
F
K
M
M
A
T
-
CS
N
V
V
RG
G
AT
L
Y
F
V
K
YV
MD
H
PELAT-Q
-
F
L
L
YG
S
L
-
A
T
M
F
G
SL
----
C
S
S
RL
L
GRF
D
R
V
TA
F
KW
I
IV
A
YSL
I
S
LL
I
F
V
TPAE-
-
--
HI
A
LI
F
ALNI
L
F
LF
V
FNTTTP
L
Q
W
L
M
AS
D
V
VDY
E
E
S
R
S
G
R
R
L
D
G
LV
F
S
T
YL
F
S
L
K
I
G
L
A
I
GG
AV
V
G
W
I
L
AYV
N
Y
S
A
S
SS
V
Q
P
VE
VL
T
T
I
K
I
L
F
C
V
V
P
VVLY
-AG
M
F
IMLS
L
Y
K
LT
D
A
RVEA
I
SR
QL
fig|316407.3.peg.260
Escherichia coli W3110 (4-440/460)
L
TM
K
D
KI
G
YG
L
GD
T
A
CG
FV
W
QA
T
M
FL
L
A
Y
FYTD
VF
G
L
S
A
GIM
GT
L
FLV
S
R
V
L
DA
V
TD
PLM
G
L
L
V
D
R
-
--TRT
R
H
G
Q
FRPF
L
L
W
GA
I
P
FG
I
VCV
L
T
F
-
YT
P
DFSAQG
K
IIY
A
CV
TY
I
LL
T
L
V
Y
T
F
VN
V
PY
C
A
M
PG
V
IT
AD
P
KE
R
H
A
L
Q
S
W
R
FF
L
A
A
A
G
S
LAI
S
G
I
A
L
--
P
LVS
I
IGK
G
DEQVG
Y
FGAMC
VL
G
L
S
G
V
V
LLYV
CF
FT
TKE
RY
TF
EVQ
P
-GS----
S
V
AK
D
L
KL
L
LG
N
S
QW
R
I
---
M
C
A
F
K
M
M
A
T
-
CS
N
V
V
RG
G
AT
L
Y
F
V
K
YV
MD
H
PELAT-Q
-
F
L
L
YG
S
L
-
A
T
M
F
G
SL
----
C
S
S
RL
L
GRF
D
R
V
TA
F
KW
I
IV
A
YSL
I
S
LL
I
F
V
TPAE-
-
--
HI
A
LI
F
ALNI
L
F
LF
V
FNTTTP
L
Q
W
L
M
AS
D
V
VDY
E
E
S
R
S
G
R
R
L
D
G
LV
F
S
T
YL
F
S
L
K
I
G
L
A
I
GG
AV
V
G
W
I
L
AYV
N
Y
S
A
S
SS
V
Q
P
VE
VL
T
T
I
K
I
L
F
C
V
V
P
VVLY
-AG
M
F
IMLS
L
Y
K
LT
D
A
RVEA
I
SR
QL
fig|316385.5.peg.245
Escherichia coli str. K-12 substr. DH10B (4-440/460)
L
TM
K
D
KI
G
YG
L
GD
T
A
CG
FV
W
QA
T
M
FL
L
A
Y
FYTD
VF
G
L
S
A
GIM
GT
L
FLV
S
R
V
L
DA
V
TD
PLM
G
L
L
V
D
R
-
--TRT
R
H
G
Q
FRPF
L
L
W
GA
I
P
FG
I
VCV
L
T
F
-
YT
P
DFSAQG
K
IIY
A
CV
TY
I
LL
T
L
V
Y
T
F
VN
V
PY
C
A
M
PG
V
IT
AD
P
KE
R
H
A
L
Q
S
W
R
FF
L
A
A
A
G
S
LAI
S
G
I
A
L
--
P
LVS
I
IGK
G
DEQVG
Y
FGAMC
VL
G
L
S
G
V
V
LLYV
CF
FT
TKE
RY
TF
EVQ
P
-GS----
S
V
AK
D
L
KL
L
LG
N
S
QW
R
I
---
M
C
A
F
K
M
M
A
T
-
CS
N
V
V
RG
G
AT
L
Y
F
V
K
YV
MD
H
PELAT-Q
-
F
L
L
YG
S
L
-
A
T
M
F
G
SL
----
C
S
S
RL
L
GRF
D
R
V
TA
F
KW
I
IV
A
YSL
I
S
LL
I
F
V
TPAE-
-
--
HI
A
LI
F
ALNI
L
F
LF
V
FNTTTP
L
Q
W
L
M
AS
D
V
VDY
E
E
S
R
S
G
R
R
L
D
G
LV
F
S
T
YL
F
S
L
K
I
G
L
A
I
GG
AV
V
G
W
I
L
AYV
N
Y
S
A
S
SS
V
Q
P
VE
VL
T
T
I
K
I
L
F
C
V
V
P
VVLY
-AG
M
F
IMLS
L
Y
K
LT
D
A
RVEA
I
SR
QL
fig|511145.12.peg.274
Escherichia coli str. K-12 substr. MG1655 (4-440/460)
L
TM
K
D
KI
G
YG
L
GD
T
A
CG
FV
W
QA
T
M
FL
L
A
Y
FYTD
VF
G
L
S
A
GIM
GT
L
FLV
S
R
V
L
DA
V
TD
PLM
G
L
L
V
D
R
-
--TRT
R
H
G
Q
FRPF
L
L
W
GA
I
P
FG
I
VCV
L
T
F
-
YT
P
DFSAQG
K
IIY
A
CV
TY
I
LL
T
L
V
Y
T
F
VN
V
PY
C
A
M
PG
V
IT
AD
P
KE
R
H
A
L
Q
S
W
R
FF
L
A
A
A
G
S
LAI
S
G
I
A
L
--
P
LVS
I
IGK
G
DEQVG
Y
FGAMC
VL
G
L
S
G
V
V
LLYV
CF
FT
TKE
RY
TF
EVQ
P
-GS----
S
V
AK
D
L
KL
L
LG
N
S
QW
R
I
---
M
C
A
F
K
M
M
A
T
-
CS
N
V
V
RG
G
AT
L
Y
F
V
K
YV
MD
H
PELAT-Q
-
F
L
L
YG
S
L
-
A
T
M
F
G
SL
----
C
S
S
RL
L
GRF
D
R
V
TA
F
KW
I
IV
A
YSL
I
S
LL
I
F
V
TPAE-
-
--
HI
A
LI
F
ALNI
L
F
LF
V
FNTTTP
L
Q
W
L
M
AS
D
V
VDY
E
E
S
R
S
G
R
R
L
D
G
LV
F
S
T
YL
F
S
L
K
I
G
L
A
I
GG
AV
V
G
W
I
L
AYV
N
Y
S
A
S
SS
V
Q
P
VE
VL
T
T
I
K
I
L
F
C
V
V
P
VVLY
-AG
M
F
IMLS
L
Y
K
LT
D
A
RVEA
I
SR
QL
fig|511145.6.peg.272
Escherichia coli str. K-12 substr. MG1655 (4-440/460)
L
TM
K
D
KI
G
YG
L
GD
T
A
CG
FV
W
QA
T
M
FL
L
A
Y
FYTD
VF
G
L
S
A
GIM
GT
L
FLV
S
R
V
L
DA
V
TD
PLM
G
L
L
V
D
R
-
--TRT
R
H
G
Q
FRPF
L
L
W
GA
I
P
FG
I
VCV
L
T
F
-
YT
P
DFSAQG
K
IIY
A
CV
TY
I
LL
T
L
V
Y
T
F
VN
V
PY
C
A
M
PG
V
IT
AD
P
KE
R
H
A
L
Q
S
W
R
FF
L
A
A
A
G
S
LAI
S
G
I
A
L
--
P
LVS
I
IGK
G
DEQVG
Y
FGAMC
VL
G
L
S
G
V
V
LLYV
CF
FT
TKE
RY
TF
EVQ
P
-GS----
S
V
AK
D
L
KL
L
LG
N
S
QW
R
I
---
M
C
A
F
K
M
M
A
T
-
CS
N
V
V
RG
G
AT
L
Y
F
V
K
YV
MD
H
PELAT-Q
-
F
L
L
YG
S
L
-
A
T
M
F
G
SL
----
C
S
S
RL
L
GRF
D
R
V
TA
F
KW
I
IV
A
YSL
I
S
LL
I
F
V
TPAE-
-
--
HI
A
LI
F
ALNI
L
F
LF
V
FNTTTP
L
Q
W
L
M
AS
D
V
VDY
E
E
S
R
S
G
R
R
L
D
G
LV
F
S
T
YL
F
S
L
K
I
G
L
A
I
GG
AV
V
G
W
I
L
AYV
N
Y
S
A
S
SS
V
Q
P
VE
VL
T
T
I
K
I
L
F
C
V
V
P
VVLY
-AG
M
F
IMLS
L
Y
K
LT
D
A
RVEA
I
SR
QL
fig|536056.3.peg.3529
Escherichia coli DH1 (4-440/460)
L
TM
K
D
KI
G
YG
L
GD
T
A
CG
FV
W
QA
T
M
FL
L
A
Y
FYTD
VF
G
L
S
A
GIM
GT
L
FLV
S
R
V
L
DA
V
TD
PLM
G
L
L
V
D
R
-
--TRT
R
H
G
Q
FRPF
L
L
W
GA
I
P
FG
I
VCV
L
T
F
-
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P
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K
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A
CV
TY
I
LL
T
L
V
Y
T
F
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V
PY
C
A
M
PG
V
IT
AD
P
KE
R
H
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L
Q
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W
R
FF
L
A
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A
G
S
LAI
S
G
I
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L
--
P
LVS
I
IGK
G
DEQVG
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G
L
S
G
V
V
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FT
TKE
RY
TF
EVQ
P
-GS----
S
V
AK
D
L
KL
L
LG
N
S
QW
R
I
---
M
C
A
F
K
M
M
A
T
-
CS
N
V
V
RG
G
AT
L
Y
F
V
K
YV
MD
H
PELAT-Q
-
F
L
L
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S
L
-
A
T
M
F
G
SL
----
C
S
S
RL
L
GRF
D
R
V
TA
F
KW
I
IV
A
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I
S
LL
I
F
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-
--
HI
A
LI
F
ALNI
L
F
LF
V
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L
Q
W
L
M
AS
D
V
VDY
E
E
S
R
S
G
R
R
L
D
G
LV
F
S
T
YL
F
S
L
K
I
G
L
A
I
GG
AV
V
G
W
I
L
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N
Y
S
AN
SS
V
Q
P
VE
VL
T
T
I
K
I
L
F
C
V
V
P
VVLY
-AG
M
F
IMLS
L
Y
K
LT
D
A
RVEA
I
SR
QL
fig|316385.7.peg.250
Escherichia coli str. K-12 substr. DH10B (1-435/455)
M
K
D
KI
G
YG
L
GD
T
A
CG
FV
W
QA
T
M
FL
L
A
Y
FYTD
VF
G
L
S
A
GIM
GT
L
FLV
S
R
V
L
DA
V
TD
PLM
G
L
L
V
D
R
-
--TRT
R
H
G
Q
FRPF
L
L
W
GA
I
P
FG
I
VCV
L
T
F
-
YT
P
DFSAQG
K
IIY
A
CV
TY
I
LL
T
L
V
Y
T
F
VN
V
PY
C
A
M
PG
V
IT
AD
P
KE
R
H
A
L
Q
S
W
R
FF
L
A
A
A
G
S
LAI
S
G
I
A
L
--
P
LVS
I
IGK
G
DEQVG
Y
FGAMC
VL
G
L
S
G
V
V
LLYV
CF
FT
TKE
RY
TF
EVQ
P
-GS----
S
V
AK
D
L
KL
L
LG
N
S
QW
R
I
---
M
C
A
F
K
M
M
A
T
-
CS
N
V
V
RG
G
AT
L
Y
F
V
K
YV
MD
H
PELAT-Q
-
F
L
L
YG
S
L
-
A
T
M
F
G
SL
----
C
S
S
RL
L
GRF
D
R
V
TA
F
KW
I
IV
A
YSL
I
S
LL
I
F
V
TPAE-
-
--
HI
A
LI
F
ALNI
L
F
LF
V
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L
Q
W
L
M
AS
D
V
VDY
E
E
S
R
S
G
R
R
L
D
G
LV
F
S
T
YL
F
S
L
K
I
G
L
A
I
GG
AV
V
G
W
I
L
AYV
N
Y
S
A
S
SS
V
Q
P
VE
VL
T
T
I
K
I
L
F
C
V
V
P
VVLY
-AG
M
F
IMLS
L
Y
K
LT
D
A
RVEA
I
SR
QL
fig|585057.4.peg.4241
Escherichia coli IAI39 (18-461/466)
D
A
L
SV
R
EKI
G
YG
L
GD
A
G
GT
VI
T
CL
I
M
N
F
L
T
F
FYTD
VF
G
L
TP
ALV
GT
L
F
I
A
L
R
V
FDA
I
S
D
PVM
G
V
I
A
D
R
-
--TQS
RWG
R
FRP
W
Q
L
W
I
A
I
P
IG
I
IGI
L
T
F
-
TV
P
DASMGV
K
IAW
A
FG
TY
L
LL
S
V
G
Y
T
A
I
N
V
PY
C
AL
IN
T
M
T
TR
H
NE
V
I
S
C
Q
S
W
R
FV
L
CG
V
A
G
FLV
S
V
G
LP
--
W
MVD
L
FGQ
G
NAARG
Y
QLGVG
VL
CA
I
A
V
V
MFLC
CF
FW
VR
E
R-
-
-
--V
P
LSTMGKF
T
L
RE
H
L
AG
L
RN
N
D
Q
L
L
L
---
M
L
V
M
S
F
L
L
I
-
NV
F
N
I
RG
G
GY
M
Y
FI
T
YVL
QG
STGYT-S
L
FFT
MV
TF
-
A
SI
IG
SV
----
I
V
S
PL
T
RRF
DT
V
KI
Y
YY
T
NL
L
LAS
L
A
V
L
M
W
F
LPSGP
A
YQ
TL
W
LA
V
ILG-
-N
GV
I
LGFTLP
L
H
FS
L
MA
FAD
DYGEW
K
T
R
V
R
S
S
G
MN
F
AF
NL
F
F
I
K
L
A
W
A
S
SA
GI
I
S
L
L
F
IFV
A
Y
Q
P
G
VE
N
Q
T
AS
S
L
G
GI
A
A
M
E
T
L
L
P
ALFH
LL
L
A
-
MAIR
F
C
K
L
N
N
P
MMSR
I
AS
D
L
RQ
fig|585057.6.peg.4249
Escherichia coli IAI39 (18-461/466)
D
A
L
SV
R
EKI
G
YG
L
GD
A
G
GT
VI
T
CL
I
M
N
F
L
T
F
FYTD
VF
G
L
TP
ALV
GT
L
F
I
A
L
R
V
FDA
I
S
D
PVM
G
V
I
A
D
R
-
--TQS
RWG
R
FRP
W
Q
L
W
I
A
I
P
IG
I
IGI
L
T
F
-
TV
P
DASMGV
K
IAW
A
FG
TY
L
LL
S
V
G
Y
T
A
I
N
V
PY
C
AL
IN
T
M
T
TR
H
NE
V
I
S
C
Q
S
W
R
FV
L
CG
V
A
G
FLV
S
V
G
LP
--
W
MVD
L
FGQ
G
NAARG
Y
QLGVG
VL
CA
I
A
V
V
MFLC
CF
FW
VR
E
R-
-
-
--V
P
LSTMGKF
T
L
RE
H
L
AG
L
RN
N
D
Q
L
L
L
---
M
L
V
M
S
F
L
L
I
-
NV
F
N
I
RG
G
GY
M
Y
FI
T
YVL
QG
STGYT-S
L
FFT
MV
TF
-
A
SI
IG
SV
----
I
V
S
PL
T
RRF
DT
V
KI
Y
YY
T
NL
L
LAS
L
A
V
L
M
W
F
LPSGP
A
YQ
TL
W
LA
V
ILG-
-N
GV
I
LGFTLP
L
H
FS
L
MA
FAD
DYGEW
K
T
R
V
R
S
S
G
MN
F
AF
NL
F
F
I
K
L
A
W
A
S
SA
GI
I
S
L
L
F
IFV
A
Y
Q
P
G
VE
N
Q
T
AS
S
L
G
GI
A
A
M
E
T
L
L
P
ALFH
LL
L
A
-
MAIR
F
C
K
L
N
N
P
MMSR
I
AS
D
L
RQ
fig|749527.3.peg.2021
Escherichia coli MS 21-1 (18-461/466)
D
A
L
SV
R
EKI
G
YG
L
GD
A
G
GT
VI
T
CL
I
M
N
F
L
T
F
FYTD
VF
G
L
TP
ALV
GT
L
F
I
A
L
R
V
FDA
I
S
D
PVM
G
V
I
A
D
R
-
--TQS
RWG
R
FRP
W
Q
L
W
I
A
I
P
IG
I
IGI
L
T
F
-
TV
P
DASMGV
K
IAW
A
FG
TY
L
LL
S
V
G
Y
T
A
I
N
V
PY
C
AL
IN
T
M
T
TR
H
NE
V
I
S
C
Q
S
W
R
FV
L
CG
V
A
G
FLV
S
V
G
LP
--
W
MVD
L
FGQ
G
NAARG
Y
QLGVG
VL
CA
I
A
V
V
MFLC
CF
FW
VR
E
R-
-
-
--V
P
LSTMGKF
T
L
RE
H
L
AG
L
RN
N
D
Q
L
L
L
---
M
L
V
M
S
F
L
L
I
-
NV
F
N
I
RG
G
GY
M
Y
FI
T
YVL
QG
STGYT-S
L
FFT
MV
TF
-
A
SI
IG
SV
----
I
V
S
PL
T
RRF
DT
V
KI
Y
YY
T
NL
L
LAS
L
A
V
L
M
W
F
LPSGP
A
YQ
TL
W
LA
V
ILG-
-N
GV
I
LGFTLP
L
H
FS
L
MA
FAD
DYGEW
K
T
R
V
R
S
S
G
MN
F
AF
NL
F
F
I
K
L
A
W
A
S
SA
GI
I
S
L
L
F
IFV
A
Y
Q
P
G
VE
N
Q
T
TS
S
L
G
GI
A
A
M
E
T
L
L
P
ALFH
LL
L
A
-
MAIR
F
C
K
L
N
N
P
MMSR
I
AS
D
L
RQ
fig|216592.1.peg.863
Escherichia coli 042 (18-461/466)
D
A
L
SV
R
EKI
G
YG
L
GD
A
G
GT
VI
T
CL
I
M
N
F
L
T
F
FYTD
VF
G
L
TP
ALV
GT
L
F
I
A
L
R
V
FDA
I
S
D
PVM
G
V
I
A
D
R
-
--TQS
H
WG
R
FRP
W
Q
L
W
I
A
I
P
IG
I
IGI
L
T
F
-
TV
P
DASMGV
K
IAW
A
FG
TY
L
LL
S
V
G
Y
T
A
I
N
V
PY
C
AL
IN
T
M
T
TR
H
NE
V
I
S
C
Q
S
W
R
FV
L
CG
V
A
G
FLV
S
V
G
LP
--
W
MVD
L
FGQ
G
NAARG
Y
QLGVG
VL
CA
I
A
V
V
MFLC
CF
FW
VR
E
R-
-
-
--V
P
LSTMGKF
T
L
RE
H
L
AG
L
RN
N
D
Q
L
L
L
---
M
L
V
M
S
F
L
L
I
-
NV
F
N
I
RG
G
GY
M
Y
FI
T
YVL
QG
STGYT-S
L
FFT
MV
TF
-
A
SI
IG
SV
----
I
V
S
PL
T
RRF
DT
V
KI
Y
YY
T
NL
L
LAS
L
A
V
L
M
W
F
LPSGP
A
YQ
TL
W
LA
V
ILG-
-N
GV
I
LGFTLP
L
H
FS
L
MA
FAD
DYGEW
K
T
R
V
R
S
S
G
MN
F
AF
NL
F
F
I
K
L
A
W
A
S
SA
GI
I
S
L
L
F
IFV
A
Y
Q
P
G
VE
N
Q
T
AS
S
L
G
GI
A
A
M
E
T
L
L
P
ALFH
LL
L
A
-
MAIR
F
C
K
L
N
N
P
MMSR
I
AS
D
L
RQ
fig|216592.3.peg.4042
Escherichia coli 042 (18-461/466)
D
A
L
SV
R
EKI
G
YG
L
GD
A
G
GT
VI
T
CL
I
M
N
F
L
T
F
FYTD
VF
G
L
TP
ALV
GT
L
F
I
A
L
R
V
FDA
I
S
D
PVM
G
V
I
A
D
R
-
--TQS
H
WG
R
FRP
W
Q
L
W
I
A
I
P
IG
I
IGI
L
T
F
-
TV
P
DASMGV
K
IAW
A
FG
TY
L
LL
S
V
G
Y
T
A
I
N
V
PY
C
AL
IN
T
M
T
TR
H
NE
V
I
S
C
Q
S
W
R
FV
L
CG
V
A
G
FLV
S
V
G
LP
--
W
MVD
L
FGQ
G
NAARG
Y
QLGVG
VL
CA
I
A
V
V
MFLC
CF
FW
VR
E
R-
-
-
--V
P
LSTMGKF
T
L
RE
H
L
AG
L
RN
N
D
Q
L
L
L
---
M
L
V
M
S
F
L
L
I
-
NV
F
N
I
RG
G
GY
M
Y
FI
T
YVL
QG
STGYT-S
L
FFT
MV
TF
-
A
SI
IG
SV
----
I
V
S
PL
T
RRF
DT
V
KI
Y
YY
T
NL
L
LAS
L
A
V
L
M
W
F
LPSGP
A
YQ
TL
W
LA
V
ILG-
-N
GV
I
LGFTLP
L
H
FS
L
MA
FAD
DYGEW
K
T
R
V
R
S
S
G
MN
F
AF
NL
F
F
I
K
L
A
W
A
S
SA
GI
I
S
L
L
F
IFV
A
Y
Q
P
G
VE
N
Q
T
AS
S
L
G
GI
A
A
M
E
T
L
L
P
ALFH
LL
L
A
-
MAIR
F
C
K
L
N
N
P
MMSR
I
AS
D
L
RQ
fig|439855.10.peg.4050
Escherichia coli SMS-3-5 (18-461/466)
D
A
L
SV
R
EKI
G
YG
L
GD
A
G
GT
VI
T
CL
I
M
N
F
L
T
F
FYTD
VF
G
L
TP
ALV
GT
L
F
I
A
L
R
V
FDA
I
S
D
PVM
G
V
I
A
D
R
-
--TQS
RWG
R
FRP
W
Q
L
W
I
A
I
P
IG
I
IGI
L
T
F
-
TV
P
DASMGV
K
IAW
A
FG
TY
L
LL
S
V
G
Y
T
A
I
N
V
PY
C
AL
IN
T
M
T
TR
H
NE
V
I
S
C
Q
S
W
R
FV
L
CG
V
A
G
FLV
S
V
G
LP
--
W
MVD
L
FGQ
G
NAARG
Y
QLGVG
VL
CA
I
A
V
V
MFLC
CF
FW
VR
E
R-
-
-
--V
P
LSTMGKF
T
L
RE
H
L
AG
L
RN
N
D
Q
L
L
L
---
M
L
V
M
S
F
L
L
I
-
NV
F
N
I
RG
G
GY
M
Y
FI
T
YVL
QG
STGYT-S
L
FFT
MV
TF
-
A
SI
IG
SV
----
I
V
S
PL
T
RRF
DT
V
KI
Y
YY
T
NL
L
LAA
L
A
V
L
M
W
F
LPSSP
A
YQ
TL
W
LA
V
ILG-
-N
GV
I
LGFTLP
L
H
FS
L
MA
FAD
DYGEW
K
T
R
V
R
S
S
G
MN
F
AF
NL
F
F
I
K
L
A
W
A
S
SA
GI
I
S
L
L
F
IFV
A
Y
Q
P
G
VE
N
Q
T
AS
S
L
G
GI
T
A
M
E
T
L
L
P
ALFH
LL
L
A
-
MAIR
F
C
K
L
N
N
P
MMSR
I
AS
D
L
RQ
fig|550677.3.peg.4156
Escherichia coli B354 (18-461/466)
D
A
L
SV
R
EKI
G
YG
L
GD
A
G
GT
VI
T
CL
I
M
N
F
L
T
F
FYTD
VF
G
L
TP
ALV
GT
L
F
I
A
L
R
V
FDA
I
S
D
PVM
G
V
I
A
D
R
-
--TQS
RWG
R
FRP
W
Q
L
W
I
A
I
P
IG
I
IGI
L
T
F
-
TV
P
DASMGV
K
IAW
A
FG
TY
L
LL
S
V
G
Y
T
A
I
N
V
PY
C
AL
IN
T
M
T
TR
H
NE
V
I
S
C
Q
S
W
R
FV
L
CG
V
A
G
FLV
S
V
G
LP
--
W
MVD
L
FGQ
G
NAARG
Y
QLGVG
VL
CA
I
A
V
V
MFLC
CF
FW
VR
E
R-
-
-
--V
P
LSTMGKF
T
L
RE
H
L
AG
L
RN
N
D
Q
L
L
L
---
M
L
V
M
S
F
L
L
I
-
NV
F
N
I
RG
G
GY
M
Y
FI
T
YVL
QG
STGYT-S
L
FFT
MV
TF
-
A
SI
IG
SV
----
I
V
S
PL
T
RRF
DT
V
KI
Y
YY
T
NL
L
LAA
L
A
V
L
M
W
F
LPSGP
A
YQ
TL
W
LA
V
ILG-
-N
GV
I
LGFTLP
L
H
FS
L
MA
FAD
DYGEW
K
T
R
V
R
S
S
G
MN
F
AF
NL
F
F
I
K
L
A
W
A
S
SA
GI
I
S
L
L
F
IFV
A
Y
Q
P
G
VE
N
Q
T
AS
S
L
G
GI
A
A
M
E
T
L
L
P
ALFH
LL
L
A
-
MAIR
F
C
K
L
N
N
P
MMSR
I
AS
D
L
RQ
fig|656437.3.peg.4040
Escherichia coli TA143 (18-461/466)
D
A
L
SV
R
EKI
G
YG
L
GD
A
G
GT
VI
T
CL
I
M
N
F
L
T
F
FYTD
VF
G
L
TP
ALV
GT
L
F
I
A
L
R
V
FDA
I
S
D
PVM
G
V
I
A
D
R
-
--TQS
RWG
R
FRP
W
Q
L
W
I
A
I
P
IG
I
IGI
L
T
F
-
TV
P
DASMGV
K
IAW
A
FG
TY
L
LL
S
V
G
Y
T
A
I
N
V
PY
C
AL
IN
T
M
T
TR
H
NE
V
I
S
C
Q
S
W
R
FV
L
CG
V
A
G
FLV
S
V
G
LP
--
W
MVD
L
FGQ
G
NAARG
Y
QLGVG
VL
CA
T
A
V
V
MFLC
CF
FW
VR
E
R-
-
-
--V
P
LSTMGKF
T
L
RE
H
L
AG
L
RN
N
D
Q
L
L
L
---
M
L
V
M
S
F
L
L
I
-
NV
F
N
I
RG
G
GY
M
Y
FI
T
YVL
QG
STGYT-S
L
FFT
MV
TF
-
A
SI
IG
SV
----
I
V
S
PL
T
RRF
DT
V
KI
Y
YY
T
NL
L
LAA
L
A
V
L
M
W
F
LPSGP
A
YQ
TL
W
LA
V
ILG-
-N
GV
I
LGFTLP
L
H
FS
L
MA
FAD
DYGEW
K
T
R
V
R
S
S
G
MN
F
AF
NL
F
F
I
K
L
A
W
A
S
SA
GI
I
S
L
L
F
IFV
A
Y
Q
P
G
VE
N
Q
T
AS
S
L
G
GI
T
A
M
E
T
L
L
P
ALFH
LL
L
A
-
MAIR
F
C
K
L
N
N
P
MMSR
I
AS
D
L
RQ
fig|656379.3.peg.4919
Escherichia coli FVEC1302 (18-461/466)
D
A
L
SV
R
EKI
G
YG
L
GD
A
G
GT
VI
T
CL
I
M
N
F
L
T
F
FYTD
VF
G
L
TP
ALV
GT
L
F
I
A
L
R
V
FDA
I
S
D
PVM
G
V
I
A
D
R
-
--TQS
H
WG
R
FRP
W
Q
L
W
I
A
I
P
IG
I
IGI
L
T
F
-
TV
P
DASMGV
K
IAW
A
FG
TY
L
LL
S
V
G
Y
T
A
I
N
V
PY
C
AL
IN
T
M
T
TR
H
NE
V
I
S
C
Q
S
W
R
FV
L
CG
V
A
G
FLV
S
V
G
LP
--
W
MVD
L
FGQ
G
NAARG
Y
QLGVG
VL
CA
I
A
V
V
MFLC
CF
FW
VR
E
R-
-
-
--V
P
LSTMGKF
T
L
RE
H
L
AG
L
RN
N
D
Q
L
L
L
---
M
L
V
M
S
F
L
L
I
-
NV
F
N
I
RG
G
GY
M
Y
FI
T
YVL
QG
STGYT-S
L
FFT
MV
TF
-
A
SI
IG
SV
----
I
V
S
PL
T
RRF
DT
V
KI
Y
YY
T
NL
L
LAA
L
A
V
L
M
W
F
LPSGP
A
YQ
TL
W
LA
V
ILG-
-N
GV
I
LGFTLP
L
H
FS
L
MA
FAD
DYGEW
K
T
R
V
R
S
S
G
MN
F
AF
NL
F
F
I
K
L
A
W
A
S
SA
GI
I
S
L
L
F
IFV
A
Y
Q
P
G
VE
N
Q
T
AS
S
L
G
GI
T
A
M
E
T
L
L
P
ALFH
LL
L
A
-
MAIR
F
C
K
L
N
N
P
MMSR
I
AS
D
L
RQ
fig|656380.3.peg.4707
Escherichia coli FVEC1412 (18-461/466)
D
A
L
SV
R
EKI
G
YG
L
GD
A
G
GT
VI
T
CL
I
M
N
F
L
T
F
FYTD
VF
G
L
TP
ALV
GT
L
F
I
A
L
R
V
FDA
I
S
D
PVM
G
V
I
A
D
R
-
--TQS
H
WG
R
FRP
W
Q
L
W
I
A
I
P
IG
I
IGI
L
T
F
-
TV
P
DASMGV
K
IAW
A
FG
TY
L
LL
S
V
G
Y
T
A
I
N
V
PY
C
AL
IN
T
M
T
TR
H
NE
V
I
S
C
Q
S
W
R
FV
L
CG
V
A
G
FLV
S
V
G
LP
--
W
MVD
L
FGQ
G
NAARG
Y
QLGVG
VL
CA
I
A
V
V
MFLC
CF
FW
VR
E
R-
-
-
--V
P
LSTMGKF
T
L
RE
H
L
AG
L
RN
N
D
Q
L
L
L
---
M
L
V
M
S
F
L
L
I
-
NV
F
N
I
RG
G
GY
M
Y
FI
T
YVL
QG
STGYT-S
L
FFT
MV
TF
-
A
SI
IG
SV
----
I
V
S
PL
T
RRF
DT
V
KI
Y
YY
T
NL
L
LAA
L
A
V
L
M
W
F
LPSGP
A
YQ
TL
W
LA
V
ILG-
-N
GV
I
LGFTLP
L
H
FS
L
MA
FAD
DYGEW
K
T
R
V
R
S
S
G
MN
F
AF
NL
F
F
I
K
L
A
W
A
S
SA
GI
I
S
L
L
F
IFV
A
Y
Q
P
G
VE
N
Q
T
AS
S
L
G
GI
T
A
M
E
T
L
L
P
ALFH
LL
L
A
-
MAIR
F
C
K
L
N
N
P
MMSR
I
AS
D
L
RQ
fig|749549.3.peg.2674
Escherichia coli MS 198-1 (18-461/466)
D
A
L
SV
R
EKI
G
YG
L
GD
A
G
GT
VI
T
CL
I
M
N
F
L
T
F
FYTD
VF
G
L
TP
ALV
GT
L
F
I
A
L
R
V
FDA
I
S
D
PVM
G
V
I
A
D
R
-
--TQS
H
WG
R
FRP
W
Q
L
W
I
A
I
P
IG
I
IGI
L
T
F
-
TV
P
DASMGV
K
IAW
A
FG
TY
L
LL
S
V
G
Y
T
A
I
N
V
PY
C
AL
IN
T
M
T
TR
H
NE
V
I
S
C
Q
S
W
R
FV
L
CG
V
A
G
FLV
S
V
G
LP
--
W
MVD
L
FGQ
G
NAARG
Y
QLGVG
VL
CA
I
A
V
V
MFLC
CF
FW
VR
E
R-
-
-
--V
P
LSTMGKF
T
L
RE
H
L
AG
L
RN
N
D
Q
L
L
L
---
M
L
V
M
S
F
L
L
I
-
NV
F
N
I
RG
G
GY
M
Y
FI
T
YVL
QG
STGYT-S
L
FFT
MV
TF
-
A
SI
IG
SV
----
I
V
S
PL
T
RRF
DT
V
KI
Y
YY
T
NL
L
LAA
L
A
V
L
M
W
F
LPSGP
A
YQ
TL
W
LA
V
ILG-
-N
GV
I
LGFTLP
L
H
FS
L
MA
FAD
DYGEW
K
T
R
V
R
S
S
G
MN
F
AF
NL
F
F
I
K
L
A
W
A
S
SA
GI
I
S
L
L
F
IFV
A
Y
Q
P
G
VE
N
Q
T
AS
S
L
G
GI
T
A
M
E
T
L
L
P
ALFH
LL
L
A
-
MAIR
F
C
K
L
N
N
P
MMSR
I
AS
D
L
RQ
fig|585056.7.peg.4272
Escherichia coli UMN026 (18-461/466)
D
A
L
SV
R
EKI
G
YG
L
GD
A
G
GT
VI
T
CL
I
M
N
F
L
T
F
FYTD
VF
G
L
TP
ALV
GT
L
F
I
A
L
R
V
FDA
I
S
D
PVM
G
V
I
A
D
R
-
--TQS
H
WG
R
FRP
W
Q
L
W
I
A
I
P
IG
I
IGI
L
T
F
-
TV
P
DASMGV
K
IAW
A
FG
TY
L
LL
S
V
G
Y
T
A
I
N
V
PY
C
AL
IN
T
M
T
TR
H
NE
V
I
S
C
Q
S
W
R
FV
L
CG
V
A
G
FLV
S
V
G
LP
--
W
MVD
L
FGQ
G
NAARG
Y
QLGVG
VL
CA
I
A
V
V
MFLC
CF
FW
VR
E
R-
-
-
--V
P
LSTMGKF
T
L
RE
H
L
AG
L
RN
N
D
Q
L
L
L
---
M
L
V
M
S
F
L
L
I
-
NV
F
N
I
RG
G
GY
M
Y
FI
T
YVL
QG
STGYT-S
L
FFT
MV
TF
-
A
SI
IG
SV
----
I
V
S
PL
T
RRF
DT
V
KI
Y
YY
T
NL
L
LAA
L
A
V
L
M
W
F
LPSGP
A
YQ
TL
W
LA
V
ILG-
-N
GV
I
LGFTLP
L
H
FS
L
MA
FAD
DYGEW
K
T
R
V
R
S
S
G
MN
F
AF
NL
F
F
I
K
L
A
W
A
S
SA
GI
I
S
L
L
F
IFV
A
Y
Q
P
G
VE
N
Q
T
AS
S
L
G
GI
T
A
M
E
T
L
L
P
ALFH
LL
L
A
-
MAIR
F
C
K
L
N
N
P
MMSR
I
AS
D
L
RQ
fig|431946.3.peg.3568
Escherichia coli SE15 (18-461/466)
D
A
L
SV
R
EKI
G
YG
L
GD
A
G
GT
VI
T
CL
I
M
N
F
L
T
F
FYTD
VF
G
L
TP
ALV
GT
L
F
I
A
L
R
V
FDA
I
S
D
PVM
G
V
I
A
D
R
-
--TQS
RWG
R
FRP
W
Q
L
W
I
A
I
P
IG
I
IGI
L
T
F
-
TV
P
DASMGV
K
IAW
A
FG
TY
L
LL
S
V
G
Y
T
A
I
N
V
PY
C
AL
IN
T
M
T
TR
Y
NE
V
I
S
C
Q
S
W
R
FV
L
CG
V
A
G
FLV
S
V
G
LP
--
W
MVD
L
FGQ
G
NAARG
Y
QLGVG
VL
CA
I
A
V
V
MFLC
CF
FW
V
C
E
R-
-
-
--V
P
LSTMGKF
T
L
RE
H
L
AG
L
RN
N
D
Q
L
L
L
---
M
L
V
M
S
F
L
L
I
-
NV
F
N
I
RG
G
GY
M
Y
FI
T
YVL
QG
STGYT-S
L
FFT
MV
TF
-
A
SI
IG
SV
----
I
V
S
PL
T
RRF
DT
V
KI
Y
YY
T
NL
L
LAA
L
A
V
L
M
W
F
LPSGP
A
YQ
TL
W
LA
V
ILG-
-N
GV
I
LGFTLP
L
H
FS
L
MA
FAD
DYGEW
K
T
R
V
R
S
S
G
MN
F
AF
NL
F
F
I
K
L
A
W
A
S
SA
GI
I
S
L
L
F
IFV
A
Y
Q
P
G
VE
N
Q
T
AS
S
L
G
GI
A
A
M
E
T
L
L
P
ALFH
LL
L
A
-
MAIR
F
C
K
L
N
N
P
MMSR
I
AS
D
L
RQ
fig|550672.3.peg.4199
Escherichia coli B088 (11-461/481)
I
SM
T
T
K
L
S
YG
F
G
A
F
G
K
D
FA
I
GI
V
Y
M
YL
M
Y
Y
YTD
VV
G
L
SV
GLV
GT
L
FLV
A
R
I
W
DA
I
N
D
PIM
G
W
I
V
NA
-
--TRS
RWGKF
K
P
W
IL
I
G
T
L
A
NS
V
ILF
L
L
F
-
SA
H
LFEGTT
Q
IVF
V
CV
TY
I
LW
G
M
T
Y
T
I
M
D
IP
F
W
S
L
VP
T
IT
LD
K
RE
R
E
Q
L
V
P
Y
P
RF
F
A
S
L
A
G
FVT
AG
V
T
L
--
P
FVN
Y
VGG
G
DRGFG
F
QMFTL
VL
IA
F
F
I
V
STII
TL
RN
V
H
E
VF
SS
DNQ
P
SAEGSHL
T
L
KA
I
V
AL
I
YK
N
D
Q
L
S
C
---
L
LG
M
A
L
A
Y
N
-
VA
S
N
I
IT
G
FA
I
YY
F
S
YV
I
G
D
ADLFP-Y
-
Y
LS
YA
GA
-
A
NL
V
T
LV
----
F
F
P
RL
V
KSL
S
R
-
RI
L
WA
G
AS
I
LPV
L
S
CG
V
LL
LMALM
S
YH
NV
V
LI
V
IAGI
L
L
NV
G
TALFWV
L
Q
VI
M
VA
DTVDYGE
Y
K
LH
V
R
C
E
S
IA
Y
S
V
QT
M
V
V
K
G
G
S
A
F
A
A
FF
IA
V
V
L
GMI
GY
V
P
N
VE
-
Q
S
TQ
A
L
L
G
MQ
F
IM
I
A
L
P
TLFF
MV
T
L
I
LYFR
FY
R
L
N
G
D
TLRR
I
QIH
L
LD
K
Y
RK
fig|478005.5.peg.614
Escherichia coli O157:H7 str. EC4486 (11-461/481)
I
SM
T
T
K
L
S
YG
F
G
A
F
G
K
D
FA
I
GI
V
Y
M
YL
M
Y
Y
YTD
VV
G
L
SV
GLV
GT
L
FLV
A
R
I
W
DA
I
N
D
PIM
G
W
I
V
NA
-
--TRS
RWGKF
K
P
W
IL
I
G
T
L
A
NS
V
ILF
L
L
F
-
SA
H
LFEGTT
Q
IAF
V
CV
TY
I
LW
G
M
T
Y
T
I
M
D
IP
F
W
S
L
VP
T
IT
LD
K
RE
R
E
Q
L
V
P
Y
P
RF
F
A
S
L
A
G
FVT
AG
V
T
L
--
P
FVN
Y
VGG
G
DRGFG
F
QMFTL
VL
IA
F
F
I
V
STII
TL
RN
V
H
E
VF
SS
DNQ
P
SAEGSHL
T
L
KA
I
V
AL
I
YK
N
D
Q
L
S
C
---
L
LG
M
A
L
A
Y
N
-
VA
S
N
I
IT
G
FA
I
YY
F
S
YV
I
G
D
ADLFP-Y
-
Y
LS
YA
GA
-
A
NL
V
T
LV
----
F
F
P
RL
V
KSL
S
R
-
RI
L
WA
G
AS
I
LPV
L
S
CG
V
LL
LMALM
S
YH
NV
V
LI
V
IAGI
L
L
NV
G
TALFWV
L
Q
VI
M
VA
DTVDYGE
Y
K
LH
V
R
C
E
S
IA
Y
S
V
QT
M
V
V
K
G
G
S
A
F
A
A
FF
IA
V
V
L
GMI
GY
V
P
N
VE
-
Q
S
TQ
A
L
L
G
MQ
F
IM
I
A
L
P
TLFF
MV
T
L
I
LYFR
FY
R
L
N
G
D
TLRR
I
QIH
L
LD
K
Y
RK
fig|344610.3.peg.1397
Escherichia coli 53638 (4-449/469)
K
L
S
YG
F
G
A
F
G
K
D
FA
I
GI
V
Y
M
YL
M
Y
Y
YTD
VV
G
L
SV
GLV
GT
L
FLV
A
R
I
W
DA
I
N
D
PIM
G
W
I
V
NA
-
--TRS
RWGKF
K
P
W
IL
I
G
T
L
A
NS
V
ILF
L
L
F
-
SA
H
LFEGTT
Q
IVF
V
CV
TY
I
LW
G
M
T
Y
T
I
M
D
IP
F
W
S
L
VP
T
IT
LD
K
RE
R
E
Q
L
V
P
Y
P
RF
F
A
S
L
A
G
FVT
AG
V
T
L
--
P
FVN
Y
VGG
G
DRGFG
F
QMFTL
VL
IA
F
F
I
V
STII
TL
RN
V
H
E
VF
SS
DNQ
P
SAEGSHL
T
L
KA
I
V
AL
I
YK
N
D
Q
L
S
C
---
L
LG
M
A
L
A
Y
N
-
VA
S
N
I
IT
G
FA
I
YY
F
S
YV
I
G
D
ADLFP-Y
-
Y
LS
YA
GA
-
A
NL
V
T
LV
----
F
F
P
RL
V
KSL
S
R
-
RI
L
WA
G
AS
I
LPV
L
S
CG
V
LL
LMALM
S
YH
NV
V
LI
V
IAGI
L
L
NV
G
TALFWV
L
Q
VI
M
VA
DTVDYGE
Y
K
LH
V
R
C
E
S
IA
Y
S
V
QT
M
V
V
K
G
G
S
A
F
A
A
FF
IA
V
V
L
GMI
GY
V
P
N
VE
-
Q
S
TQ
A
L
L
G
MQ
F
IM
I
A
L
P
TLFF
MV
T
L
I
LYFR
FY
R
L
N
G
D
TLRR
I
QIH
L
LD
K
Y
RK
fig|481805.3.peg.4196
Escherichia coli ATCC 8739 (4-449/469)
K
L
S
YG
F
G
A
F
G
K
D
FA
I
GI
V
Y
M
YL
M
Y
Y
YTD
VV
G
L
SV
GLV
GT
L
FLV
A
R
I
W
DA
I
N
D
PIM
G
W
I
V
NA
-
--TRS
RWGKF
K
P
W
IL
I
G
T
L
A
NS
V
ILF
L
L
F
-
SA
H
LFEGTT
Q
IVF
V
CV
TY
I
LW
G
M
T
Y
T
I
M
D
IP
F
W
S
L
VP
T
IT
LD
K
RE
R
E
Q
L
V
P
Y
P
RF
F
A
S
L
A
G
FVT
AG
V
T
L
--
P
FVN
Y
VGG
G
DRGFG
F
QMFTL
VL
IA
F
F
I
V
STII
TL
RN
V
H
E
VF
SS
DNQ
P
SAEGSHL
T
L
KA
I
V
AL
I
YK
N
D
Q
L
S
C
---
L
LG
M
A
L
A
Y
N
-
VA
S
N
I
IT
G
FA
I
YY
F
S
YV
I
G
D
ADLFP-Y
-
Y
LS
YA
GA
-
A
NL
V
T
LV
----
F
F
P
RL
V
KSL
S
R
-
RI
L
WA
G
AS
I
LPV
L
S
CG
V
LL
LMALM
S
YH
NV
V
LI
V
IAGI
L
L
NV
G
TALFWV
L
Q
VI
M
VA
DTVDYGE
Y
K
LH
V
R
C
E
S
IA
Y
S
V
QT
M
V
V
K
G
G
S
A
F
A
A
FF
IA
V
V
L
GMI
GY
V
P
N
VE
-
Q
S
TQ
A
L
L
G
MQ
F
IM
I
A
L
P
TLFF
MV
T
L
I
LYFR
FY
R
L
N
G
D
TLRR
I
QIH
L
LD
K
Y
RK
fig|344601.3.peg.1153
Escherichia coli B171 (4-449/469)
K
L
S
YG
F
G
A
F
G
K
D
FA
I
GI
V
Y
M
YL
M
Y
Y
YTD
VV
G
L
SV
GLV
GT
L
FLV
A
R
I
W
DA
I
N
D
PIM
G
W
I
V
NA
-
--TRS
RWGKF
K
P
W
IL
I
G
T
L
A
NS
V
ILF
L
L
F
-
SA
H
LFEGTT
Q
IVF
V
CV
TY
I
LW
G
M
T
Y
T
I
M
D
IP
F
W
S
L
VP
T
IT
LD
K
RE
R
E
Q
L
V
P
Y
P
RF
F
A
S
L
A
G
FVT
AG
V
T
L
--
P
FVN
Y
VGG
G
DRGFG
F
QMFTL
VL
IA
F
F
I
V
STII
TL
RN
V
H
E
VF
SS
DNQ
P
SAEGSHL
T
L
KA
I
V
AL
I
YK
N
D
Q
L
S
C
---
L
LG
M
A
L
A
Y
N
-
VA
S
N
I
IT
G
FA
I
YY
F
S
YV
I
G
D
ADLFP-Y
-
Y
LS
YA
GA
-
A
NL
V
T
LV
----
F
F
P
RL
V
KSL
S
R
-
RI
L
WA
G
AS
I
LPV
L
S
CG
V
LL
LMALM
S
YH
NV
V
LI
V
IAGI
L
L
NV
G
TALFWV
L
Q
VI
M
VA
DTVDYGE
Y
K
LH
V
R
C
E
S
IA
Y
S
V
QT
M
V
V
K
G
G
S
A
F
A
A
FF
IA
V
V
L
GMI
GY
V
P
N
VE
-
Q
S
TQ
A
L
L
G
MQ
F
IM
I
A
L
P
TLFF
MV
T
L
I
LYFR
FY
R
L
N
G
D
TLRR
I
QIH
L
LD
K
Y
RK
fig|340186.3.peg.1046
Escherichia coli E110019 (4-449/469)
K
L
S
YG
F
G
A
F
G
K
D
FA
I
GI
V
Y
M
YL
M
Y
Y
YTD
VV
G
L
SV
GLV
GT
L
FLV
A
R
I
W
DA
I
N
D
PIM
G
W
I
V
NA
-
--TRS
RWGKF
K
P
W
IL
I
G
T
L
A
NS
V
ILF
L
L
F
-
SA
H
LFEGTT
Q
IVF
V
CV
TY
I
LW
G
M
T
Y
T
I
M
D
IP
F
W
S
L
VP
T
IT
LD
K
RE
R
E
Q
L
V
P
Y
P
RF
F
A
S
L
A
G
FVT
AG
V
T
L
--
P
FVN
Y
VGG
G
DRGFG
F
QMFTL
VL
IA
F
F
I
V
STII
TL
RN
V
H
E
VF
SS
DNQ
P
SAEGSHL
T
L
KA
I
V
AL
I
YK
N
D
Q
L
S
C
---
L
LG
M
A
L
A
Y
N
-
VA
S
N
I
IT
G
FA
I
YY
F
S
YV
I
G
D
ADLFP-Y
-
Y
LS
YA
GA
-
A
NL
V
T
LV
----
F
F
P
RL
V
KSL
S
R
-
RI
L
WA
G
AS
I
LPV
L
S
CG
V
LL
LMALM
S
YH
NV
V
LI
V
IAGI
L
L
NV
G
TALFWV
L
Q
VI
M
VA
DTVDYGE
Y
K
LH
V
R
C
E
S
IA
Y
S
V
QT
M
V
V
K
G
G
S
A
F
A
A
FF
IA
V
V
L
GMI
GY
V
P
N
VE
-
Q
S
TQ
A
L
L
G
MQ
F
IM
I
A
L
P
TLFF
MV
T
L
I
LYFR
FY
R
L
N
G
D
TLRR
I
QIH
L
LD
K
Y
RK
fig|340185.3.peg.1413
Escherichia coli E22 (4-449/469)
K
L
S
YG
F
G
A
F
G
K
D
FA
I
GI
V
Y
M
YL
M
Y
Y
YTD
VV
G
L
SV
GLV
GT
L
FLV
A
R
I
W
DA
I
N
D
PIM
G
W
I
V
NA
-
--TRS
RWGKF
K
P
W
IL
I
G
T
L
A
NS
V
ILF
L
L
F
-
SA
H
LFEGTT
Q
IVF
V
CV
TY
I
LW
G
M
T
Y
T
I
M
D
IP
F
W
S
L
VP
T
IT
LD
K
RE
R
E
Q
L
V
P
Y
P
RF
F
A
S
L
A
G
FVT
AG
V
T
L
--
P
FVN
Y
VGG
G
DRGFG
F
QMFTL
VL
IA
F
F
I
V
STII
TL
RN
V
H
E
VF
SS
DNQ
P
SAEGSHL
T
L
KA
I
V
AL
I
YK
N
D
Q
L
S
C
---
L
LG
M
A
L
A
Y
N
-
VA
S
N
I
IT
G
FA
I
YY
F
S
YV
I
G
D
ADLFP-Y
-
Y
LS
YA
GA
-
A
NL
V
T
LV
----
F
F
P
RL
V
KSL
S
R
-
RI
L
WA
G
AS
I
LPV
L
S
CG
V
LL
LMALM
S
YH
NV
V
LI
V
IAGI
L
L
NV
G
TALFWV
L
Q
VI
M
VA
DTVDYGE
Y
K
LH
V
R
C
E
S
IA
Y
S
V
QT
M
V
V
K
G
G
S
A
F
A
A
FF
IA
V
V
L
GMI
GY
V
P
N
VE
-
Q
S
TQ
A
L
L
G
MQ
F
IM
I
A
L
P
TLFF
MV
T
L
I
LYFR
FY
R
L
N
G
D
TLRR
I
QIH
L
LD
K
Y
RK
fig|331111.3.peg.2273
Escherichia coli E24377A (4-449/469)
K
L
S
YG
F
G
A
F
G
K
D
FA
I
GI
V
Y
M
YL
M
Y
Y
YTD
VV
G
L
SV
GLV
GT
L
FLV
A
R
I
W
DA
I
N
D
PIM
G
W
I
V
NA
-
--TRS
RWGKF
K
P
W
IL
I
G
T
L
A
NS
V
ILF
L
L
F
-
SA
H
LFEGTT
Q
IVF
V
CV
TY
I
LW
G
M
T
Y
T
I
M
D
IP
F
W
S
L
VP
T
IT
LD
K
RE
R
E
Q
L
V
P
Y
P
RF
F
A
S
L
A
G
FVT
AG
V
T
L
--
P
FVN
Y
VGG
G
DRGFG
F
QMFTL
VL
IA
F
F
I
V
STII
TL
RN
V
H
E
VF
SS
DNQ
P
SAEGSHL
T
L
KA
I
V
AL
I
YK
N
D
Q
L
S
C
---
L
LG
M
A
L
A
Y
N
-
VA
S
N
I
IT
G
FA
I
YY
F
S
YV
I
G
D
ADLFP-Y
-
Y
LS
YA
GA
-
A
NL
V
T
LV
----
F
F
P
RL
V
KSL
S
R
-
RI
L
WA
G
AS
I
LPV
L
S
CG
V
LL
LMALM
S
YH
NV
V
LI
V
IAGI
L
L
NV
G
TALFWV
L
Q
VI
M
VA
DTVDYGE
Y
K
LH
V
R
C
E
S
IA
Y
S
V
QT
M
V
V
K
G
G
S
A
F
A
A
FF
IA
V
V
L
GMI
GY
V
P
N
VE
-
Q
S
TQ
A
L
L
G
MQ
F
IM
I
A
L
P
TLFF
MV
T
L
I
LYFR
FY
R
L
N
G
D
TLRR
I
QIH
L
LD
K
Y
RK
fig|331112.3.peg.4075
Escherichia coli HS (4-449/469)
K
L
S
YG
F
G
A
F
G
K
D
FA
I
GI
V
Y
M
YL
M
Y
Y
YTD
VV
G
L
SV
GLV
GT
L
FLV
A
R
I
W
DA
I
N
D
PIM
G
W
I
V
NA
-
--TRS
RWGKF
K
P
W
IL
I
G
T
L
A
NS
V
ILF
L
L
F
-
SA
H
LFEGTT
Q
IVF
V
CV
TY
I
LW
G
M
T
Y
T
I
M
D
IP
F
W
S
L
VP
T
IT
LD
K
RE
R
E
Q
L
V
P
Y
P
RF
F
A
S
L
A
G
FVT
AG
V
T
L
--
P
FVN
Y
VGG
G
DRGFG
F
QMFTL
VL
IA
F
F
I
V
STII
TL
RN
V
H
E
VF
SS
DNQ
P
SAEGSHL
T
L
KA
I
V
AL
I
YK
N
D
Q
L
S
C
---
L
LG
M
A
L
A
Y
N
-
VA
S
N
I
IT
G
FA
I
YY
F
S
YV
I
G
D
ADLFP-Y
-
Y
LS
YA
GA
-
A
NL
V
T
LV
----
F
F
P
RL
V
KSL
S
R
-
RI
L
WA
G
AS
I
LPV
L
S
CG
V
LL
LMALM
S
YH
NV
V
LI
V
IAGI
L
L
NV
G
TALFWV
L
Q
VI
M
VA
DTVDYGE
Y
K
LH
V
R
C
E
S
IA
Y
S
V
QT
M
V
V
K
G
G
S
A
F
A
A
FF
IA
V
V
L
GMI
GY
V
P
N
VE
-
Q
S
TQ
A
L
L
G
MQ
F
IM
I
A
L
P
TLFF
MV
T
L
I
LYFR
FY
R
L
N
G
D
TLRR
I
QIH
L
LD
K
Y
RK
fig|316385.5.peg.4265
Escherichia coli str. K-12 substr. DH10B (11-461/481)
I
SM
T
T
K
L
S
YG
F
G
A
F
G
K
D
FA
I
GI
V
Y
M
YL
M
Y
Y
YTD
VV
G
L
SV
GLV
GT
L
FLV
A
R
I
W
DA
I
N
D
PIM
G
W
I
V
NA
-
--TRS
RWGKF
K
P
W
IL
I
G
T
L
A
NS
V
ILF
L
L
F
-
SA
H
LFEGTT
Q
IVF
V
CV
TY
I
LW
G
M
T
Y
T
I
M
D
IP
F
W
S
L
VP
T
IT
LD
K
RE
R
E
Q
L
V
P
Y
P
RF
F
A
S
L
A
G
FVT
AG
V
T
L
--
P
FVN
Y
VGG
G
DRGFG
F
QMFTL
VL
IA
F
F
I
V
STII
TL
RN
V
H
E
VF
SS
DNQ
P
SAEGSHL
T
L
KA
I
V
AL
I
YK
N
D
Q
L
S
C
---
L
LG
M
A
L
A
Y
N
-
VA
S
N
I
IT
G
FA
I
YY
F
S
YV
I
G
D
ADLFP-Y
-
Y
LS
YA
GA
-
A
NL
V
T
LV
----
F
F
P
RL
V
KSL
S
R
-
RI
L
WA
G
AS
I
LPV
L
S
CG
V
LL
LMALM
S
YH
NV
V
LI
V
IAGI
L
L
NV
G
TALFWV
L
Q
VI
M
VA
D
I
VDYGE
Y
K
LH
V
R
C
E
S
IA
Y
S
V
QT
M
V
V
K
G
G
S
A
F
A
A
FF
IA
V
V
L
GMI
GY
V
P
N
VE
-
Q
S
TQ
A
L
L
G
MQ
F
IM
I
A
L
P
TLFF
MV
T
L
I
LYFR
FY
R
L
N
G
D
TLRR
I
QIH
L
LD
K
Y
RK
fig|83334.1.peg.5080
Escherichia coli O157:H7 (4-449/469)
K
L
S
YG
F
G
A
F
G
K
D
FA
I
GI
V
Y
M
YL
M
Y
Y
YTD
VV
G
L
SV
GLV
GT
L
FLV
A
R
I
W
DA
I
N
D
PIM
G
W
I
V
NA
-
--TRS
RWGKF
K
P
W
IL
I
G
T
L
A
NS
V
ILF
L
L
F
-
SA
H
LFEGTT
Q
IAF
V
CV
TY
I
LW
G
M
T
Y
T
I
M
D
IP
F
W
S
L
VP
T
IT
LD
K
RE
R
E
Q
L
V
P
Y
P
RF
F
A
S
L
A
G
FVT
AG
V
T
L
--
P
FVN
Y
VGG
G
DRGFG
F
QMFTL
VL
IA
F
F
I
V
STII
TL
RN
V
H
E
VF
SS
DNQ
P
SAEGSHL
T
L
KA
I
V
AL
I
YK
N
D
Q
L
S
C
---
L
LG
M
A
L
A
Y
N
-
VA
S
N
I
IT
G
FA
I
YY
F
S
YV
I
G
D
ADLFP-Y
-
Y
LS
YA
GA
-
A
NL
V
T
LV
----
F
F
P
RL
V
KSL
S
R
-
RI
L
WA
G
AS
I
LPV
L
S
CG
V
LL
LMALM
S
YH
NV
V
LI
V
IAGI
L
L
NV
G
TALFWV
L
Q
VI
M
VA
DTVDYGE
Y
K
LH
V
R
C
E
S
IA
Y
S
V
QT
M
V
V
K
G
G
S
A
F
A
A
FF
IA
V
V
L
GMI
GY
V
P
N
VE
-
Q
S
TQ
A
L
L
G
MQ
F
IM
I
A
L
P
TLFF
MV
T
L
I
LYFR
FY
R
L
N
G
D
TLRR
I
QIH
L
LD
K
Y
RK
fig|155864.1.peg.5061
Escherichia coli O157:H7 EDL933 (4-449/469)
K
L
S
YG
F
G
A
F
G
K
D
FA
I
GI
V
Y
M
YL
M
Y
Y
YTD
VV
G
L
SV
GLV
GT
L
FLV
A
R
I
W
DA
I
N
D
PIM
G
W
I
V
NA
-
--TRS
RWGKF
K
P
W
IL
I
G
T
L
A
NS
V
ILF
L
L
F
-
SA
H
LFEGTT
Q
IAF
V
CV
TY
I
LW
G
M
T
Y
T
I
M
D
IP
F
W
S
L
VP
T
IT
LD
K
RE
R
E
Q
L
V
P
Y
P
RF
F
A
S
L
A
G
FVT
AG
V
T
L
--
P
FVN
Y
VGG
G
DRGFG
F
QMFTL
VL
IA
F
F
I
V
STII
TL
RN
V
H
E
VF
SS
DNQ
P
SAEGSHL
T
L
KA
I
V
AL
I
YK
N
D
Q
L
S
C
---
L
LG
M
A
L
A
Y
N
-
VA
S
N
I
IT
G
FA
I
YY
F
S
YV
I
G
D
ADLFP-Y
-
Y
LS
YA
GA
-
A
NL
V
T
LV
----
F
F
P
RL
V
KSL
S
R
-
RI
L
WA
G
AS
I
LPV
L
S
CG
V
LL
LMALM
S
YH
NV
V
LI
V
IAGI
L
L
NV
G
TALFWV
L
Q
VI
M
VA
DTVDYGE
Y
K
LH
V
R
C
E
S
IA
Y
S
V
QT
M
V
V
K
G
G
S
A
F
A
A
FF
IA
V
V
L
GMI
GY
V
P
N
VE
-
Q
S
TQ
A
L
L
G
MQ
F
IM
I
A
L
P
TLFF
MV
T
L
I
LYFR
FY
R
L
N
G
D
TLRR
I
QIH
L
LD
K
Y
RK
fig|83333.1.peg.4032
Escherichia coli K12 (4-449/469)
K
L
S
YG
F
G
A
F
G
K
D
FA
I
GI
V
Y
M
YL
M
Y
Y
YTD
VV
G
L
SV
GLV
GT
L
FLV
A
R
I
W
DA
I
N
D
PIM
G
W
I
V
NA
-
--TRS
RWGKF
K
P
W
IL
I
G
T
L
A
NS
V
ILF
L
L
F
-
SA
H
LFEGTT
Q
IVF
V
CV
TY
I
LW
G
M
T
Y
T
I
M
D
IP
F
W
S
L
VP
T
IT
LD
K
RE
R
E
Q
L
V
P
Y
P
RF
F
A
S
L
A
G
FVT
AG
V
T
L
--
P
FVN
Y
VGG
G
DRGFG
F
QMFTL
VL
IA
F
F
I
V
STII
TL
RN
V
H
E
VF
SS
DNQ
P
SAEGSHL
T
L
KA
I
V
AL
I
YK
N
D
Q
L
S
C
---
L
LG
M
A
L
A
Y
N
-
VA
S
N
I
IT
G
FA
I
YY
F
S
YV
I
G
D
ADLFP-Y
-
Y
LS
YA
GA
-
A
NL
V
T
LV
----
F
F
P
RL
V
KSL
S
R
-
RI
L
WA
G
AS
I
LPV
L
S
CG
V
LL
LMALM
S
YH
NV
V
LI
V
IAGI
L
L
NV
G
TALFWV
L
Q
VI
M
VA
D
I
VDYGE
Y
K
LH
V
R
C
E
S
IA
Y
S
V
QT
M
V
V
K
G
G
S
A
F
A
A
FF
IA
V
V
L
GMI
GY
V
P
N
VE
-
Q
S
TQ
A
L
L
G
MQ
F
IM
I
A
L
P
TLFF
MV
T
L
I
LYFR
FY
R
L
N
G
D
TLRR
I
QIH
L
LD
K
Y
RK
fig|316407.3.peg.3957
Escherichia coli W3110 (4-449/469)
K
L
S
YG
F
G
A
F
G
K
D
FA
I
GI
V
Y
M
YL
M
Y
Y
YTD
VV
G
L
SV
GLV
GT
L
FLV
A
R
I
W
DA
I
N
D
PIM
G
W
I
V
NA
-
--TRS
RWGKF
K
P
W
IL
I
G
T
L
A
NS
V
ILF
L
L
F
-
SA
H
LFEGTT
Q
IVF
V
CV
TY
I
LW
G
M
T
Y
T
I
M
D
IP
F
W
S
L
VP
T
IT
LD
K
RE
R
E
Q
L
V
P
Y
P
RF
F
A
S
L
A
G
FVT
AG
V
T
L
--
P
FVN
Y
VGG
G
DRGFG
F
QMFTL
VL
IA
F
F
I
V
STII
TL
RN
V
H
E
VF
SS
DNQ
P
SAEGSHL
T
L
KA
I
V
AL
I
YK
N
D
Q
L
S
C
---
L
LG
M
A
L
A
Y
N
-
VA
S
N
I
IT
G
FA
I
YY
F
S
YV
I
G
D
ADLFP-Y
-
Y
LS
YA
GA
-
A
NL
V
T
LV
----
F
F
P
RL
V
KSL
S
R
-
RI
L
WA
G
AS
I
LPV
L
S
CG
V
LL
LMALM
S
YH
NV
V
LI
V
IAGI
L
L
NV
G
TALFWV
L
Q
VI
M
VA
D
I
VDYGE
Y
K
LH
V
R
C
E
S
IA
Y
S
V
QT
M
V
V
K
G
G
S
A
F
A
A
FF
IA
V
V
L
GMI
GY
V
P
N
VE
-
Q
S
TQ
A
L
L
G
MQ
F
IM
I
A
L
P
TLFF
MV
T
L
I
LYFR
FY
R
L
N
G
D
TLRR
I
QIH
L
LD
K
Y
RK
fig|749540.3.peg.4721
Escherichia coli MS 146-1 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
AS
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
LF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGW
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|679205.4.peg.1868
Escherichia coli MS 124-1 (21-466/468)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|749533.3.peg.3936
Escherichia coli MS 84-1 (21-466/468)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|585396.4.peg.4865
Escherichia coli O111:H- str. 11128 (21-466/468)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|573235.3.peg.4849
Escherichia coli O26:H11 str. 11368 (21-466/468)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|656408.3.peg.4347
Escherichia coli H591 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QKLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|679206.4.peg.3475
Escherichia coli MS 119-7 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QKLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|656443.3.peg.4827
Escherichia coli TA271 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QKLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|595496.3.peg.3874
Escherichia coli BW2952 (21-466/468)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
AS
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|536056.3.peg.4371
Escherichia coli DH1 (21-466/468)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
AS
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|585034.4.peg.3967
Escherichia coli IAI1 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QKLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
EIQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
SA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|585034.5.peg.3964
Escherichia coli IAI1 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QKLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
EIQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
SA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|749537.3.peg.2679
Escherichia coli MS 115-1 (21-466/468)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
AS
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|749538.3.peg.1613
Escherichia coli MS 116-1 (21-466/468)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
AS
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|749544.3.peg.2940
Escherichia coli MS 175-1 (21-466/468)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
AS
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|749545.3.peg.3769
Escherichia coli MS 182-1 (21-466/468)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
AS
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|749548.3.peg.827
Escherichia coli MS 196-1 (21-466/468)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
AS
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|749532.3.peg.2910
Escherichia coli MS 78-1 (21-466/468)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
AS
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|316407.3.peg.3267
Escherichia coli W3110 (21-466/468)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
AS
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|316385.7.peg.4091
Escherichia coli str. K-12 substr. DH10B (21-466/468)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
AS
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|511145.12.peg.3989
Escherichia coli str. K-12 substr. MG1655 (21-466/468)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
AS
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|511145.6.peg.3972
Escherichia coli str. K-12 substr. MG1655 (21-466/468)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
AS
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|344601.3.peg.3027
Escherichia coli B171 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|344601.5.peg.3160
Escherichia coli B171 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|340185.3.peg.2337
Escherichia coli E22 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|340185.4.peg.2473
Escherichia coli E22 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|656417.3.peg.4778
Escherichia coli M605 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|585395.4.peg.4495
Escherichia coli O103:H2 str. 12009 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|409438.11.peg.4334
Escherichia coli SE11 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|431946.3.peg.3877
Escherichia coli SE15 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|656440.3.peg.4415
Escherichia coli TA206 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|340184.6.peg.1546
Escherichia coli B7A (21-466/468)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QKLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
EIQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|595495.4.peg.3539
Escherichia coli KO11 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
AS
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|566546.3.peg.3944
Escherichia coli W (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
AS
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|566546.4.peg.4120
Escherichia coli W (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
AS
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|585057.4.peg.3232
Escherichia coli IAI39 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|585057.6.peg.3239
Escherichia coli IAI39 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|439855.10.peg.4394
Escherichia coli SMS-3-5 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|656379.3.peg.5115
Escherichia coli FVEC1302 (21-466/468)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQIG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
TFSC
LA
FF
G
SAFVNS
L
N
WAL
IS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|749549.3.peg.741
Escherichia coli MS 198-1 (21-466/468)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQIG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
TFSC
LA
FF
G
SAFVNS
L
N
WAL
IS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|340184.3.peg.1467
Escherichia coli B7A (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QKLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
EIQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|679204.3.peg.3671
Escherichia coli MS 145-7 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QKLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
EIQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|656414.3.peg.4409
Escherichia coli H736 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
AS
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|83333.1.peg.3797
Escherichia coli K12 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
AS
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|316385.5.peg.4006
Escherichia coli str. K-12 substr. DH10B (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
AS
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|216592.1.peg.4635
Escherichia coli 042 (25-470/472)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQIG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|216592.3.peg.4407
Escherichia coli 042 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQIG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|656380.3.peg.5011
Escherichia coli FVEC1412 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQIG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
TFSC
LA
FF
G
SAFVNS
L
N
WAL
IS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|585056.7.peg.4573
Escherichia coli UMN026 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQIG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
TFSC
LA
FF
G
SAFVNS
L
N
WAL
IS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|550676.3.peg.4085
Escherichia coli B185 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
NF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|316401.4.peg.4704
Escherichia coli ETEC H10407 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
NF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|331111.12.peg.4621
Escherichia coli E24377A (21-466/468)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQFG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|331111.3.peg.2021
Escherichia coli E24377A (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQFG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|562.371.peg.1947
Escherichia coli 1044A (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---S
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|562.373.peg.2546
Escherichia coli 1125A (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---S
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|562.372.peg.3729
Escherichia coli 1212A (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---S
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|562.374.peg.3536
Escherichia coli 536A (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---S
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|83334.1.peg.4773
Escherichia coli O157:H7 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---S
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|155864.1.peg.4810
Escherichia coli O157:H7 EDL933 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---S
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|155864.8.peg.4772
Escherichia coli O157:H7 EDL933 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---S
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|444454.5.peg.3895
Escherichia coli O157:H7 str. EC4024 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---S
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|444449.5.peg.3352
Escherichia coli O157:H7 str. EC4042 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---S
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|444448.5.peg.2107
Escherichia coli O157:H7 str. EC4045 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---S
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|444453.5.peg.2248
Escherichia coli O157:H7 str. EC4076 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---S
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|444452.5.peg.1863
Escherichia coli O157:H7 str. EC4113 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---S
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|444450.8.peg.5189
Escherichia coli O157:H7 str. EC4115 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---S
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|444451.5.peg.2909
Escherichia coli O157:H7 str. EC4196 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---S
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|444447.5.peg.2271
Escherichia coli O157:H7 str. EC4206 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---S
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|478004.5.peg.2322
Escherichia coli O157:H7 str. EC4401 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---S
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|478005.5.peg.2173
Escherichia coli O157:H7 str. EC4486 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---S
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|478006.5.peg.2239
Escherichia coli O157:H7 str. EC4501 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---S
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|478007.5.peg.2295
Escherichia coli O157:H7 str. EC508 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---S
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|478008.5.peg.1992
Escherichia coli O157:H7 str. EC869 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---S
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|637388.3.peg.559
Escherichia coli O157:H7 str. FRIK2000 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---S
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|570506.3.peg.3152
Escherichia coli O157:H7 str. FRIK966 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---S
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|386585.9.peg.5014
Escherichia coli O157:H7 str. Sakai (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---S
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|544404.4.peg.4999
Escherichia coli O157:H7 str. TW14359 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---S
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|502346.5.peg.1809
Escherichia coli O157:H7 str. TW14588 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---S
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|701177.3.peg.4682
Escherichia coli O55:H7 str. CB9615 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---S
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|749531.3.peg.3370
Escherichia coli MS 69-1 (21-466/468)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
IG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QKLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|358709.5.peg.3037
Escherichia coli 101-1 (21-466/468)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GK
L
RPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
AS
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|413997.3.peg.3949
Escherichia coli B str. REL606 (21-466/468)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GK
L
RPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
AS
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|511693.5.peg.3967
Escherichia coli BL21 (21-466/468)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GK
L
RPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
AS
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|469008.4.peg.4318
Escherichia coli BL21(DE3) (21-466/468)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GK
L
RPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
AS
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|749547.3.peg.3642
Escherichia coli MS 187-1 (21-466/468)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GK
L
RPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
AS
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|585397.7.peg.4567
Escherichia coli ED1a (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LEI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
KTQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|585397.9.peg.4564
Escherichia coli ED1a (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
P
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LEI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
KTQ
P
TNPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
GA
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|344610.3.peg.2290
Escherichia coli 53638 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
L
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
AS
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|344610.7.peg.2319
Escherichia coli 53638 (14-459/461)
L
PF
KEK
L
S
YG
I
GD
L
ASN
IL
L
DI
G
T
LYLL
K
FYTD
VL
G
L
L
G
TYG
G
II
FL
I
S
K
F
F
T
AFTD
MGT
G
I
M
L
DS
R
RKIGP
K
-
GKFRPFIL
Y
A
S
F
P
VT
L
LAI
A
N
F
-
VG
T
PFDVTG
K
TVM
A
TI
LF
M
LY
GL
F
F
S
M
M
N
CS
YGA
M
VP
AIT
KN
P
NE
RA
S
L
A
A
W
R
QG
GAT
L
GL
LLC
TV
G
F
V
--
P
VMN
L
IEG
N
QQLG-
Y
IFAAT
L
F
S
L
F
G
L
L
FMWI
C
Y
SG
V
KE
RY
-
V
ETQ
P
ANPAQKP
G
L
LQ
S
F
RA
I
AG
N
R
PL
F
I
---
LCI
A
NLC
T
L
-
GA
F
N
V
KL
A
IQ
VYY
T
Q
YVLND
PILLSYM
GFF
S
MG
CI
-
-
-
F
IG
VF
----
L
M
P
AS
V
RRF
GKK
KV
Y
IG
G
LL
I
WVL
G
D
LL
N
Y
F
F---G
G
--
GS
V
SF
V
AFSC
LA
FF
G
SAFVNS
L
N
WAL
VS
DTV
E
YGEW
R
TG
V
R
S
EG
TV
YTG
FT
F
F
RK
V
S
Q
A
L
A
G
FF
PG
W
ML
TQI
GY
V
P
N
VA
-
Q
A
DH
TI
E
G
L
R
Q
LI
F
I
Y
P
SALA
VV
T
I
V
AMGC
FY
S
L
N
E
K
MYVR
IVEEI
EA
RK
R
fig|656419.3.peg.4970
Escherichia coli M718 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|155864.8.peg.4771
Escherichia coli O157:H7 EDL933 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LX
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|550676.3.peg.4084
Escherichia coli B185 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTT
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
LIG
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|562.371.peg.1949
Escherichia coli 1044A (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|562.373.peg.2545
Escherichia coli 1125A (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|562.372.peg.3731
Escherichia coli 1212A (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|562.374.peg.3535
Escherichia coli 536A (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|83334.1.peg.4772
Escherichia coli O157:H7 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|444454.5.peg.3894
Escherichia coli O157:H7 str. EC4024 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|444449.5.peg.3351
Escherichia coli O157:H7 str. EC4042 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|444448.5.peg.2106
Escherichia coli O157:H7 str. EC4045 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|444453.5.peg.2247
Escherichia coli O157:H7 str. EC4076 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|444452.5.peg.1864
Escherichia coli O157:H7 str. EC4113 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|444450.8.peg.5188
Escherichia coli O157:H7 str. EC4115 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|444451.5.peg.2910
Escherichia coli O157:H7 str. EC4196 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|444447.5.peg.2270
Escherichia coli O157:H7 str. EC4206 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|478004.5.peg.2321
Escherichia coli O157:H7 str. EC4401 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|478005.5.peg.2172
Escherichia coli O157:H7 str. EC4486 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|478006.5.peg.2240
Escherichia coli O157:H7 str. EC4501 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|478007.5.peg.2296
Escherichia coli O157:H7 str. EC508 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|386585.9.peg.5013
Escherichia coli O157:H7 str. Sakai (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|544404.4.peg.4998
Escherichia coli O157:H7 str. TW14359 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|502346.5.peg.1810
Escherichia coli O157:H7 str. TW14588 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|701177.3.peg.4681
Escherichia coli O55:H7 str. CB9615 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|216592.3.peg.4406
Escherichia coli 042 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|656379.3.peg.5114
Escherichia coli FVEC1302 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|656380.3.peg.5010
Escherichia coli FVEC1412 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|749549.3.peg.743
Escherichia coli MS 198-1 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|585056.7.peg.4572
Escherichia coli UMN026 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|155864.1.peg.4809
Escherichia coli O157:H7 EDL933 (13-456/469)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LX
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|562.371.peg.1948
Escherichia coli 1044A (13-456/469)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|562.372.peg.3730
Escherichia coli 1212A (13-456/469)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|216592.1.peg.4636
Escherichia coli 042 (13-456/469)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|749549.3.peg.742
Escherichia coli MS 198-1 (13-456/469)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|439855.10.peg.4393
Escherichia coli SMS-3-5 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTT
P
T--GHKA
S
I
LK
S
F
CA
I
FH
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
MI
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|656417.3.peg.4777
Escherichia coli M605 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
I
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTT
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
C
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|431946.3.peg.3876
Escherichia coli SE15 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
I
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTT
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
C
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|585057.4.peg.3233
Escherichia coli IAI39 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTT
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|585057.6.peg.3240
Escherichia coli IAI39 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTT
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|585397.7.peg.4566
Escherichia coli ED1a (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
I
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTT
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
C
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
I
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|585397.9.peg.4563
Escherichia coli ED1a (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
I
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTT
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
C
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
I
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|656440.3.peg.4414
Escherichia coli TA206 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
I
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTT
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
C
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
I
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|656414.3.peg.4408
Escherichia coli H736 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTT
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
LIG
VL
----
L
A
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|749540.3.peg.4720
Escherichia coli MS 146-1 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTT
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
LIG
VL
----
L
A
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|83333.1.peg.3796
Escherichia coli K12 (11-454/485)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTT
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
LIG
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|749531.3.peg.3369
Escherichia coli MS 69-1 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
NI
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|439855.10.peg.1742
Escherichia coli SMS-3-5 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
TE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KM
Q
QQ
LIS
fig|585396.4.peg.2166
Escherichia coli O111:H- str. 11128 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FL
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|358709.5.peg.3038
Escherichia coli 101-1 (11-454/467)
L
NL
W
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|413997.3.peg.3948
Escherichia coli B str. REL606 (11-454/467)
L
NL
W
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|511693.5.peg.3966
Escherichia coli BL21 (11-454/467)
L
NL
W
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|469008.4.peg.4319
Escherichia coli BL21(DE3) (11-454/467)
L
NL
W
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|316401.4.peg.4703
Escherichia coli ETEC H10407 (11-454/467)
L
NL
W
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|749547.3.peg.3643
Escherichia coli MS 187-1 (11-454/467)
L
NL
W
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|431946.3.peg.1535
Escherichia coli SE15 (2-451/457)
NQQ
L
SW
R
A
I
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
T
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|344610.3.peg.2291
Escherichia coli 53638 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTT
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
LIG
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|344610.7.peg.2320
Escherichia coli 53638 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTT
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
LIG
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|595496.3.peg.3873
Escherichia coli BW2952 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTT
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
LIG
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|536056.3.peg.4372
Escherichia coli DH1 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTT
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
LIG
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|749538.3.peg.1614
Escherichia coli MS 116-1 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTT
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
LIG
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|749544.3.peg.2941
Escherichia coli MS 175-1 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTT
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
LIG
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|749548.3.peg.828
Escherichia coli MS 196-1 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTT
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
LIG
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|316407.3.peg.3268
Escherichia coli W3110 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTT
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
LIG
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|316385.5.peg.4005
Escherichia coli str. K-12 substr. DH10B (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTT
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
LIG
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|316385.7.peg.4090
Escherichia coli str. K-12 substr. DH10B (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTT
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
LIG
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|511145.12.peg.3988
Escherichia coli str. K-12 substr. MG1655 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTT
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
LIG
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|511145.6.peg.3971
Escherichia coli str. K-12 substr. MG1655 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTT
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
LIG
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|216593.1.peg.387
Escherichia coli E2348/69 (2-451/457)
NQQ
L
SW
R
A
I
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
C
K
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|574521.7.peg.1737
Escherichia coli O127:H6 str. E2348/69 (2-451/457)
NQQ
L
SW
R
A
I
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
C
K
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|478008.5.peg.1991
Escherichia coli O157:H7 str. EC869 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
AMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|637388.3.peg.558
Escherichia coli O157:H7 str. FRIK2000 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
AMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|570506.3.peg.3151
Escherichia coli O157:H7 str. FRIK966 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
SI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFSLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
I
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
AMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|749537.3.peg.2678
Escherichia coli MS 115-1 (13-456/469)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTT
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
LIG
VL
----
L
V
P
LT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|362663.8.peg.1575
Escherichia coli 536 (2-451/457)
NQQ
L
SW
R
A
I
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|362663.9.peg.1579
Escherichia coli 536 (2-451/457)
NQQ
L
SW
R
A
I
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|405955.13.peg.1699
Escherichia coli APEC O1 (2-451/457)
NQQ
L
SW
R
A
I
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|405955.9.peg.1384
Escherichia coli APEC O1 (2-451/457)
NQQ
L
SW
R
A
I
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|585397.7.peg.1834
Escherichia coli ED1a (2-451/457)
NQQ
L
SW
R
A
I
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|585397.9.peg.1829
Escherichia coli ED1a (2-451/457)
NQQ
L
SW
R
A
I
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|340197.3.peg.3581
Escherichia coli F11 (2-451/457)
NQQ
L
SW
R
A
I
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|340197.5.peg.3743
Escherichia coli F11 (2-451/457)
NQQ
L
SW
R
A
I
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|714962.3.peg.1767
Escherichia coli IHE3034 (2-451/457)
NQQ
L
SW
R
A
I
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|656417.3.peg.2109
Escherichia coli M605 (2-451/457)
NQQ
L
SW
R
A
I
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|685038.3.peg.1633
Escherichia coli O83:H1 str. NRG 857C (2-451/457)
NQQ
L
SW
R
A
I
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|585035.6.peg.1654
Escherichia coli S88 (2-451/457)
NQQ
L
SW
R
A
I
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|869729.3.peg.1929
Escherichia coli UM146 (2-451/457)
NQQ
L
SW
R
A
I
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|364106.7.peg.1846
Escherichia coli UTI89 (2-451/457)
NQQ
L
SW
R
A
I
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|364106.8.peg.1849
Escherichia coli UTI89 (2-451/457)
NQQ
L
SW
R
A
I
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|525281.3.peg.891
Escherichia coli 83972 (2-451/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|655817.3.peg.1954
Escherichia coli ABU 83972 (2-451/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|656393.3.peg.2406
Escherichia coli H299 (2-451/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|585057.4.peg.1508
Escherichia coli IAI39 (2-451/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|585057.6.peg.1507
Escherichia coli IAI39 (2-451/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|753642.3.peg.1545
Escherichia coli NC101 (2-451/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|656440.3.peg.1454
Escherichia coli TA206 (2-451/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|344601.3.peg.3028
Escherichia coli B171 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
VT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|344601.5.peg.3161
Escherichia coli B171 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
VT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|340184.3.peg.1466
Escherichia coli B7A (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
VT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|340184.6.peg.1545
Escherichia coli B7A (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
VT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|340185.3.peg.2338
Escherichia coli E22 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
VT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|340185.4.peg.2474
Escherichia coli E22 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
VT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|331111.12.peg.4620
Escherichia coli E24377A (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
VT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|331111.3.peg.2020
Escherichia coli E24377A (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
VT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|656408.3.peg.4346
Escherichia coli H591 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
VT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|585034.4.peg.3966
Escherichia coli IAI1 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
VT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|585034.5.peg.3963
Escherichia coli IAI1 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
VT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|595495.4.peg.3540
Escherichia coli KO11 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
VT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|679206.4.peg.3474
Escherichia coli MS 119-7 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
VT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|679205.4.peg.1867
Escherichia coli MS 124-1 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
VT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|679204.3.peg.3670
Escherichia coli MS 145-7 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
VT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|749545.3.peg.3770
Escherichia coli MS 182-1 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
VT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|749533.3.peg.3935
Escherichia coli MS 84-1 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
VT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|585395.4.peg.4496
Escherichia coli O103:H2 str. 12009 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
VT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|585396.4.peg.4864
Escherichia coli O111:H- str. 11128 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
VT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|573235.3.peg.4850
Escherichia coli O26:H11 str. 11368 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
VT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|409438.11.peg.4333
Escherichia coli SE11 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
VT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|656443.3.peg.4826
Escherichia coli TA271 (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
VT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|566546.3.peg.3945
Escherichia coli W (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
VT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|566546.4.peg.4119
Escherichia coli W (11-454/467)
L
NL
R
EKI
A
YGMGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
VT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
fig|1040638.4.peg.3665
Escherichia coli O104:H4 str. LB226692 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|6666666.5357.peg.3547
Escherichia coli TY-2482 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|585055.6.peg.1811
Escherichia coli 55989 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|585055.8.peg.1815
Escherichia coli 55989 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|550672.3.peg.2456
Escherichia coli B088 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|344601.3.peg.361
Escherichia coli B171 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|344601.5.peg.358
Escherichia coli B171 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|550676.3.peg.1920
Escherichia coli B185 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|340185.3.peg.3302
Escherichia coli E22 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|340185.4.peg.3478
Escherichia coli E22 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|331111.12.peg.2111
Escherichia coli E24377A (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|331111.3.peg.4253
Escherichia coli E24377A (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|562.375.peg.1718
Escherichia coli EC4100B (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|585034.4.peg.1650
Escherichia coli IAI1 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|585034.5.peg.1645
Escherichia coli IAI1 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|679207.4.peg.4267
Escherichia coli MS 107-1 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|656444.3.peg.2511
Escherichia coli TA280 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KM
Q
QQ
LIS
fig|562.376.peg.2938
Escherichia coli WV_060327 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KM
Q
QQ
LIS
fig|340184.3.peg.986
Escherichia coli B7A (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|340184.6.peg.1021
Escherichia coli B7A (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|340186.3.peg.3443
Escherichia coli E110019 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|340186.5.peg.3596
Escherichia coli E110019 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|656408.3.peg.1757
Escherichia coli H591 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|595495.4.peg.2823
Escherichia coli KO11 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|679206.4.peg.1284
Escherichia coli MS 119-7 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|679204.3.peg.534
Escherichia coli MS 145-7 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
S
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|573235.3.peg.2380
Escherichia coli O26:H11 str. 11368 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|409438.11.peg.1884
Escherichia coli SE11 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|656443.3.peg.2266
Escherichia coli TA271 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|566546.3.peg.1036
Escherichia coli W (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|566546.4.peg.1771
Escherichia coli W (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|656419.3.peg.2322
Escherichia coli M718 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTIT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|216592.1.peg.2221
Escherichia coli 042 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSIW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KM
Q
QQ
LIS
fig|216592.3.peg.1855
Escherichia coli 042 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSIW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KM
Q
QQ
LIS
fig|679205.4.peg.1649
Escherichia coli MS 124-1 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KM
Q
QQ
LIS
fig|199310.1.peg.1946
Escherichia coli CFT073 (2-451/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
LS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|199310.4.peg.1875
Escherichia coli CFT073 (2-451/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
LS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QA
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|562.371.peg.4462
Escherichia coli 1044A (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
I
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|562.373.peg.5365
Escherichia coli 1125A (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
I
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|562.372.peg.4696
Escherichia coli 1212A (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
I
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|562.374.peg.4416
Escherichia coli 536A (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
I
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|83334.1.peg.2350
Escherichia coli O157:H7 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
I
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|155864.1.peg.2360
Escherichia coli O157:H7 EDL933 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
I
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|155864.8.peg.2200
Escherichia coli O157:H7 EDL933 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
I
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|444454.5.peg.5602
Escherichia coli O157:H7 str. EC4024 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
I
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|444449.5.peg.548
Escherichia coli O157:H7 str. EC4042 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
I
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|444448.5.peg.4856
Escherichia coli O157:H7 str. EC4045 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
I
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|444453.5.peg.4720
Escherichia coli O157:H7 str. EC4076 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
I
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|444452.5.peg.3506
Escherichia coli O157:H7 str. EC4113 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
I
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|444450.8.peg.2367
Escherichia coli O157:H7 str. EC4115 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
I
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|444451.5.peg.3387
Escherichia coli O157:H7 str. EC4196 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
I
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|444447.5.peg.5132
Escherichia coli O157:H7 str. EC4206 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
I
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|478004.5.peg.4117
Escherichia coli O157:H7 str. EC4401 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
I
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|478005.5.peg.4823
Escherichia coli O157:H7 str. EC4486 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
I
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|478006.5.peg.4057
Escherichia coli O157:H7 str. EC4501 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
I
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|478007.5.peg.3532
Escherichia coli O157:H7 str. EC508 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
I
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|478008.5.peg.4527
Escherichia coli O157:H7 str. EC869 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
I
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|637388.3.peg.5026
Escherichia coli O157:H7 str. FRIK2000 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
I
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|570506.3.peg.4206
Escherichia coli O157:H7 str. FRIK966 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
I
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|386585.9.peg.2433
Escherichia coli O157:H7 str. Sakai (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
I
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|544404.4.peg.2230
Escherichia coli O157:H7 str. TW14359 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
I
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|502346.5.peg.5082
Escherichia coli O157:H7 str. TW14588 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
I
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|701177.3.peg.2008
Escherichia coli O55:H7 str. CB9615 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
I
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|358709.5.peg.1131
Escherichia coli 101-1 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
NI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|550677.3.peg.2999
Escherichia coli B354 (2-451/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
L
fig|585395.4.peg.1839
Escherichia coli O103:H2 str. 12009 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
F
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|670888.3.peg.109
Escherichia coli 1827-70 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
NI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|316401.4.peg.1899
Escherichia coli ETEC H10407 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
NI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|656414.3.peg.1923
Escherichia coli H736 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
NI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|331112.3.peg.1592
Escherichia coli HS (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
NI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|331112.6.peg.1659
Escherichia coli HS (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
NI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|656437.3.peg.1827
Escherichia coli TA143 (2-450/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KM
Q
QQ
fig|344610.3.peg.3169
Escherichia coli 53638 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
IFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
NI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|344610.7.peg.5264
Escherichia coli 53638 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
IFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
NI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|656379.3.peg.2084
Escherichia coli FVEC1302 (2-450/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
AP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GSC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
A
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KM
Q
QQ
fig|656380.3.peg.3049
Escherichia coli FVEC1412 (2-450/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
AP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GSC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
A
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KM
Q
QQ
fig|585056.7.peg.2090
Escherichia coli UMN026 (2-450/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
AP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
KI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GSC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
A
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KM
Q
QQ
fig|413997.3.peg.1660
Escherichia coli B str. REL606 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GT
IL
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
NI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|511693.5.peg.1685
Escherichia coli BL21 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GT
IL
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
NI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|469008.4.peg.2089
Escherichia coli BL21(DE3) (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GT
IL
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
NI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|637912.3.peg.2121
Escherichia coli OP50 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GT
IL
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHSS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
NI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|481805.3.peg.2171
Escherichia coli ATCC 8739 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VP
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
NI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
X
X
L
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|595496.3.peg.1576
Escherichia coli BW2952 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VL
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
NI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|536056.3.peg.2138
Escherichia coli DH1 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VL
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
NI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|83333.1.peg.1602
Escherichia coli K12 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VL
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
NI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|316407.3.peg.1573
Escherichia coli W3110 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VL
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
NI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|316385.5.peg.1728
Escherichia coli str. K-12 substr. DH10B (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VL
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
NI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|316385.7.peg.1773
Escherichia coli str. K-12 substr. DH10B (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VL
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
NI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|511145.12.peg.1687
Escherichia coli str. K-12 substr. MG1655 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VL
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
NI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|511145.6.peg.1671
Escherichia coli str. K-12 substr. MG1655 (2-453/457)
NQQ
L
SW
RTI
V
G
Y
S
L
GD
V
A
N
N
FA
F
AM
G
A
L
F
LL
S
Y
YTD
VA
G
V
G
A
AAA
GTM
L
L
L
V
R
V
FDAF
A
D
VFA
G
R
V
V
DS
-
--VNT
RWGKFRPF
L
LFG
T
A
P
LM
I
FSV
L
V
F
W
VL
T
DWSHGS
K
VVY
A
YL
TYM
GL
GL
C
YSLVNIPYG
S
L
AT
A
M
T
QQ
P
QS
RA
R
L
G
A
A
R
--
G
IA
A
S
L
TFV
CL
A
FL
IG
P
SIK
N
SSP
E
EMVSV
Y
HFWTI
VL
A
I
A
G
M
V
LYFI
CF
KS
T
R
E
NV
-
V
RI-
-
---VAQP
SL
NI
SL
QT
L
KR
N
R
PL
F
M
---
LCI
G
A
LC
V
L
I
ST
F
A
V
S-
A
SS
L
F
YV
R
YVLND
------T
G
L
FT
VL
V
L
V
Q
NL
V
G
TV
ASAP
L
V
P
GM
V
ARI
GKK
NT
F
LI
G
AL
L
GTC
G
Y
LL
-
FF
WVSVW
S
--
LP
V
AL
V
ALA-
I
A
SI
G
QGVTMT
V
M
WAL
EA
DTV
E
YGE
Y
L
TG
V
R
I
EG
LT
Y
S
L
FS
F
T
RK
C
G
Q
A
I
GG
SI
P
A
F
I
L
GLS
GY
I
AN
QV
-
Q
T
PE
V
I
M
GIR
T
S
I
A
L
V
P
CGFM
LLA
F
V
II-W
FY
P
LT
D
K
KFKE
IV
V
EI
DN
RK
KV
Q
QQ
LIS
fig|749532.3.peg.2909
Escherichia coli MS 78-1 (1-434/447)
MGD
V
G
SN
LM
L
CI
G
T
LYLL
K
FYTD
EL
G
M
PA
YYG
G
II
FLV
A
K
F
F
T
AFTD
MLT
G
F
L
L
DS
R
KNIGP
K
-
GKFRPFIL
Y
A
A
V
P
AA
L
IAT
L
Q
F
-
IA
T
TFCLPV
K
TTI
A
TA
LF
M
MF
GL
S
YSL
M
N
CS
YGA
M
IP
AIT
KN
P
NE
RA
Q
L
A
A
Y
R
QG
GAT
I
GL
LIC
TV
A
F
I
--
P
LQS
L
F-S
D
STVG-
Y
ACAAL
M
F
SI
G
G
F
I
FMML
C
Y
RG
V
KE
HY
-
V
DTA
P
T--GHKA
S
I
LK
S
F
CA
I
FR
N
P
PL
L
V
---
LCI
A
NLC
T
L
-
AA
F
N
I
KL
A
IQ
VYY
T
Q
YVLND
INLLSWM
GFF
S
MG
CI
-
-
-
L
V
G
VL
----
L
V
P
VT
V
KCF
GKK
QV
Y
LA
G
MV
L
WAV
G
D
I
L
N
Y
F
W---G
S
--
NS
F
TF
V
MFSC
V
A
FF
G
TAFVNS
L
N
WAL
VP
DTVDYGEW
K
TG
I
R
A
EG
SV
YTG
YT
F
F
RK
I
S
A
A
L
A
G
FL
PG
I
ML
TQI
GY
V
P
N
IA
-
Q
S
DA
T
L
Q
G
L
R
Q
LI
F
I
W
P
CALA
II
A
A
L
TMGF
FY
T
L
N
E
K
RFAL
I
I
EEI
NQ
RK
NK
Consen1
Primary consensus
MKsevL
keki
YgmGD
asn
f
g
Lyll
fYTD
Gipa
GtmfLv
r
fdAftD
G
l
Ds
-
rwGKFRPfiLfga
P
i
l
f
-
t
K
A
tym
gL
yslvNipYgal
aiT
P
Ra
L
a
R
gat
gl
tv
fl
--
P
l
d
y
vlsi
g
v
Cf
tkE
-
V
p
sl
sl
i
N
pl
i
---
LcI
nlc
l
-
f
v
a
vyYv
yvLnd
gfft
ci
-
nliG
----
L
p
v
gKk
f
g
l
g
ll
fF
s
--
v
v
la
g
l
Wal
DTVdYGEw
tG
R
eG
ytg
F
rK
g
A
gG
pg
mL
GY
an
-
Qn
ti
gir
li
i
P
lla
v
fY
Lt
k
iveei
rK
cQQqftSQEVQN
Consen2
Secondary consensus
nqq
rti
s
gnh
l
v
fmm
y
gg
iil
k
lt
i
rr
k
-
w
a
l
a
yw
p
lft
t
ft
m
cs
csm
vm
i
s
lia
sg
cl
m
ig
n
f
fa
a
y
vr
-
g
df
l
qw
vgl
t
ail
vi
-
i
g
f
t
wi
gt
-
lls
v
v
-
fv
asap
k
t
c
v
y
t
i
i
ia
y
git
f
f
h
v
vm
e
y
n
t
f
l
l
s
a
ia
i
pa
a
vl
ili
sf
l
y
n
h
v
vql
g
q
lis
Consensus 1
(when a gap)
Conservative difference
Consensus 2
(when a gap)
Nonconservative diff.
Other character